                         SEQUENCE LISTING

<110>  Amylin Pharmaceuticals, Inc.
 
<120>  GLP-1 Receptor Agonist Compounds for Sleep Enhancement

<130>  0247US-PRO

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  39
<212>  PRT
<213>  Heloderma suspectum

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is amidated

<400>  1

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  2
<211>  39
<212>  PRT
<213>  Heloderma horridum

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is amidated

<400>  2

His Ser Asp Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  3
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is optionally amidated

<400>  3

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  4
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is optionally amidated

<400>  4

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Phe Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  5
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is optionally amidated

<400>  5

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Ala Arg Leu Phe Ile Glu Phe Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  6
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Gly is optionally amidated

<400>  6

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly 
            20                  25                  30  


<210>  7
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Gly is optionally amidated

<400>  7

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly 
            20                  25                  30  


<210>  8
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Gly is optionally amidated

<400>  8

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Phe Leu Lys Asn Gly Gly 
            20                  25                  30  


<210>  9
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Gly is optionally amidated

<400>  9

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Ala Arg Leu Phe Ile Glu Phe Leu Lys Asn Gly Gly 
            20                  25                  30  


<210>  10
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn is optionally amidated

<400>  10

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn 
            20                  25              


<210>  11
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn is optionally amidated

<400>  11

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn 
            20                  25              


<210>  12
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn is optionally amidated

<400>  12

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Phe Leu Lys Asn 
            20                  25              


<210>  13
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn is optionally amidated

<400>  13

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Ala Arg Leu Phe Ile Glu Phe Leu Lys Asn 
            20                  25              


<210>  14
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is optionally amidated

<400>  14

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Glu Phe Leu Lys Gln Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  15
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is optionally amidated

<400>  15

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Glu Trp Leu Lys Gln Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  16
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  octyl-Gly

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is optionally amidated

<400>  16

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Gly Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Gln Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  17
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  octyl-Gly

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is optionally amidated

<400>  17

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Gln Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  18
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Ser is optionally amidated

<400>  18

His Gly Glu Phe Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Gln Gly Gly Pro Ser 
            20                  25                  30          


Lys Glu Ile Ile Ser 
        35          


<210>  19
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is optionally amidated

<400>  19

His Gly Glu Phe Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Glu Trp Leu Lys Gln Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  20
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is optionally amidated

<400>  20

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Val Lys Ile Leu Glu Ala 
1               5                   10                  15      


Glu Ala Val Arg Lys Phe Ile Glu Phe Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  21
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Lys is optionally amidated

<400>  21

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  22
<211>  31
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Gly is optionally amidated

<400>  22

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  23
<211>  30
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Arg is optionally amidated

<400>  23

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  24
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Arg is optionally amidated

<400>  24

His Aib Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Phe Leu Val Arg Aib Arg 
            20                  25                  30  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Ala, Val, or Gly

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Gly, Lys, or Glu

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Gln or Lys

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Ala or Glu

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  Val or Lys

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  Lys, Asn, or Art
<220>
<221>  VARIANT
<222>  (30)..(30)
<223>  Ala or Glu; optionally amidated when 31 is absent

220>
<221>  VARIANT
<222>  (31)..(31)
<223>  Gly, His, Pro, or absent; optionally amidated

<400>  25

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Ala Gly 
            20                  25                  30


<210>  26
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Gly is optionally amidated

<400>  26

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  27
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Gly is optionally amidated

<400>  27

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Glu Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  28
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Gly is optionally amidated

<400>  28

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  29
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Gly is optionally amidated

<400>  29

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly 
            20                  25                  30      


<210>  30
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Gly is optionally amidated

<400>  30

His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly 
            20                  25                  30      


<210>  31
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Gly is optionally amidated

<400>  31

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly Gly 
            20                  25                  30      


<210>  32
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Gly is optionally amidated

<400>  32

His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly Gly 
            20                  25                  30      


<210>  33
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Pro is optionally amidated

<400>  33

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro 
            20                  25                  30      


<210>  34
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Pro is optionally amidated

<400>  34

His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro 
            20                  25                  30      


<210>  35
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Pro is optionally amidated

<400>  35

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly Pro 
            20                  25                  30      


<210>  36
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Pro is optionally amidated

<400>  36

His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly Pro 
            20                  25                  30      


<210>  37
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Gly is optionally amidated

<400>  37

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly 
            20                  25                  30  


<210>  38
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Gly is optionally amidated

<400>  38

His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly 
            20                  25                  30  


<210>  39
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Gly is optionally amidated

<400>  39

His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly 
            20                  25                  30  


<210>  40
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Gly is optionally amidated

<400>  40

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly 
            20                  25                  30  


<210>  41
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Pro or Glu

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Phe, Val or Ala

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Leu, Glu or Ala

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Asn or Ala

<220>
<221>  VARIANT
<222>  (230)..(230)
<223>  Lys or absent

<400>  41

Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro 
1               5                   10                  15      


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    50                  55                  60                  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            100                 105                 110         


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        115                 120                 125             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
    130                 135                 140                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145                 150                 155                 160 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                165                 170                 175     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
            180                 185                 190         


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
        195                 200                 205             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    210                 215                 220                 


Ser Leu Ser Leu Gly Lys 
225                 230 


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<400>  42

Gly Gly Gly Gly Ser 
1               5   


<210>  43
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<400>  43

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly 
        275 


<210>  44
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Gly, D-Ala, Val, Leu, Ile, Ser or Thr

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Gly, Glu, Asp or Lys

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys is optionally amidated

<400>  44

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Cys Cys 
        35                  40  


<210>  45
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide construct

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys is optionally amidated

<400>  45

His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Ile Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Cys Cys 
        35                  40  


