
                                SEQUENCE LISTING

<110> Mount Sinai School of Medicine of New York University 

<120> MONOCLONAL ANTIBODIES AGAINST INFLUENZA
  VIRUS GENERATED BY CYCLICAL ADMINISTRATION AND USES THEREOF
  

<130> 6923-155-228

<140> To Be Assigned
<141> To Be Assigned

<150> 61/181,263          
<151> 2009-05-26  

<150> 61/224,302          
<151> 2009-07-09  

<150> 61/305,898         
<151> 2010-02-18

<160> 125

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acids 405 to 513 of the hemagglutinin
      polypeptide of Influenza strain A/Hong Kong/1/1968
      (H3)

<400> 1
Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu
 1               5                  10                  15      
Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr
            20                  25                  30          
Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Arg
        35                  40                  45              
Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys
    50                  55                  60                  
Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Glu Ser Ile Arg Asn Gly
65                  70                  75                  80  
Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe
                85                  90                  95      
Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys Asp
            100                 105                 


<210> 2
<211> 804
<212> DNA
<213> Mus musculus

<220>
<223> mAB 7A7 HC sequence comprising variable region

<400> 2
atggactcca ggctcaattt agttttcctt gtccttattt taaaaggtgt ccagtgtgat 60
gtgcagctgg tggagtctgg gggaggctta gtgcagcctg gagggtcccg gaaactctcc 120
tgtgcagcct ctggattcac tttcagtagc tttggaatgc actgggttcg tcaggctcca 180
gagaaggggc tggagtgggt cgcatacatt agtagtggca gtagtaccat ctactatgca 240
gacacagtga agggccgatt caccatctcc agagacaatc ccaagaacac cctgttcctg 300
caaatgacca gtctaaggtc tgaggacacg gccatgtatt actgtgcaag aaattacgac 360
gaggacttcg atgtctgggg cgcagggacc acggtcaccg tctcctcagc caaaacaaca 420
cccccatcag tctatccact ggcccctggg tgtggagata caactggttc ctccgtgact 480
ctgggatgcc tggtcaaggg ctacttccct gagtcagtga ctgtgacttg gaactctgga 540
tccctgtcca gcagtgtgca caccttccca gctctcctgc agtctggact ctacactatg 600
agcagctcag tgactgtccc ctccagcacc tggccaagtc agaccgtcac ctgcagcgtt 660
gctcacccag ccagcagcac cacggtggac aaaaaacttg agcccagcgg gcccatttca 720
acaatcaacc cctgtcctcc atgcaaggag tgtcacaaat gcccagctcc taacctcgag 780
ggtggaccat ccgtcttcat cttc                                        804

<210> 3
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Junctional amino acid residues for mAB 7A7 HC

<400> 3
Cys Ala Arg Asn Tyr Asp Glu Asp Phe Asp Val Trp
 1               5                  10          


<210> 4
<211> 716
<212> DNA
<213> Mus musculus

<220>
<223> mAB 7A7 LC sequence comprising variable region

<400> 4
tgaagttgcc tgttaggctg ttggtgctga tgttctggat tcctgcttcc agcagtgatg 60
ttgtgatgac ccaaactcca ctctccctgc ctgtcagtct tggagatcaa gcctccatct 120
cttgcagatc tagtcagagc cttgtacaca gtaatggaaa cacctattta cattggtacc 180
tgcagaagcc aggccagtct ccaaagctcc tgatctacaa agtttccaac cgattttctg 240
gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc aagatcagca 300
gagtggaggc tgaggatctg ggagtttatt tctgctctca aagtacacat gttccgtgga 360
cgttcggtgg aggcaccaag ctggaaatca aacgggctga tgctgcacca actgtatcca 420
tcttcccacc atccagtgag cagttaacat ctggaggtgc ctcagtcgtg tgcttcttga 480
acaacttcta ccccaaagac atcaatgtca agtggaagat tgatggcagt gaacgacaaa 540
atggcgtcct gaacagttgg actgatcagg acagcaaaga cagcacctac agcatgagca 600
gcaccctcac gttgaccaag gacgagtatg aacgacataa cagctatacc tgtgaggcca 660
ctcacaagac atcaacttca cccattgtca agagcttcaa caggaatgag tgttag     716

<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Junctional amino acid residues for mAB 7A7 LC

<400> 5
Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe
 1               5                  10      


<210> 6
<211> 268
<212> PRT
<213> Mus musculus

<220>
<223> mAB 7A7 HC sequence comprising variable region

<400> 6
Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Ile Leu Lys Gly
 1               5                  10                  15      
Val Gln Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
        35                  40                  45              
Ser Ser Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala
65                  70                  75                  80  
Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn
                85                  90                  95      
Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asn Tyr Asp Glu Asp Phe Asp Val Trp Gly Ala
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val
    130                 135                 140                 
Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val Thr
145                 150                 155                 160 
Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val Thr
                165                 170                 175     
Trp Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala Leu
            180                 185                 190         
Leu Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro Ser
        195                 200                 205             
Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro Ala
    210                 215                 220                 
Ser Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser
225                 230                 235                 240 
Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala
                245                 250                 255     
Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe
            260                 265             


<210> 7
<211> 238
<212> PRT
<213> Mus musculus

<220>
<223> mAB 7A7 LC sequence comprising variable region

<400> 7
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala
 1               5                  10                  15      
Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val
            20                  25                  30          
Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu
        35                  40                  45              
Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro
    50                  55                  60                  
Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
                85                  90                  95      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys
            100                 105                 110         
Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
        115                 120                 125             
Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro
    130                 135                 140                 
Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly
                165                 170                 175     
Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp
        195                 200                 205             
Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr
    210                 215                 220                 
Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
225                 230                 235             


<210> 8
<211> 772
<212> DNA
<213> Mus musculus

<220>
<223> mAB 12D1 HC sequence comprising variable region

<400> 8
atggctgtct tggggctgct cttctgcctg gtgacattcc caagctgtgt cctatcccag 60
gtgcacctgg agcagtcagg acctggccta gtgcagccct cacagagcct gtccatcacc 120
tgcacagtct ctggtttctc attaacaacg tatggtgtac actgggttcg ccagtctcca 180
ggaaagggtc tggagtggct gggagtgata tggagaggtg gaagcataga ctataatgca 240
gctttcatat ccagactgag catcagcaag gacaattcca agagccaagt tttctttaaa 300
atgaacagtc tgcaagctaa tgacacagcc atatattact gtgccagaaa ttggggtagg 360
tacggatact tcgatgtctg gggcgcaggg accacggtca ccgtctcctc agccaaaacg 420
acacccccat ctgtctatcc actggcccct ggatctgctg cccaaactaa ctccatggtg 480
accctgggat gcctggtcaa gggctatttc cctgagccag tgacagtgac ctggaactct 540
ggatccctgt ccagcggtgt gcacaccttc ccagctgtcc tgcagtctga cctctacact 600
ctgagcagct cagtgactgt cccctccagc acctggccca gcgagaccgt cacctgcaac 660
gttgcccacc cggccagcag caccaaggtg gacaagaaaa ttgtgcccag ggattgtggt 720
tgtaagcctt gcatatgtac agtcccagaa gtatcatctg tcttcatctt cc         772

<210> 9
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Junctional amino acid residues for mAB 12D1 HC

<400> 9
Cys Ala Arg Asn Trp Gly Arg Tyr Gly Tyr Phe Asp Val Trp
 1               5                  10                  


<210> 10
<211> 717
<212> DNA
<213> Mus musculus

<220>
<223> mAB 12D1 HC sequence comprising variable region

<400> 10
atggagacag acacactcct gctatgggtg ctgctgctct gggttccagg ttccacaggt 60
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc 120
atatcctgca gagccagtga aagtgttgat agttatggca acagttttat gcactggtac 180
cagcagaaac caggacagcc acccaaagtc ctcatctatc gtgcatccaa cctagaatct 240
gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat 300
cctgtggagg ctgatgatgt tgcaacctat tactgtcagc aaagtaatgg ggatcctcgg 360
acgttcggtg gaggcaccaa gctggaaatc aaacgggctg atgctgcacc aactgtatcc 420
atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg 480
aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa 540
aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc 600
agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc 660
actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgttag    717

<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Junctional amino acid residues for mAB 12D1 LC

<400> 11
Cys Gln Gln Ser Asn Gly Asp Pro Arg Thr Phe
 1               5                  10      


<210> 12
<211> 257
<212> PRT
<213> Mus musculus

<220>
<223> mAB 12D1 HC sequence comprising variable region

<400> 12
Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys
 1               5                  10                  15      
Val Leu Ser Gln Val His Leu Glu Gln Ser Gly Pro Gly Leu Val Gln
            20                  25                  30          
Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu
        35                  40                  45              
Thr Thr Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Leu Gly Val Ile Trp Arg Gly Gly Ser Ile Asp Tyr Asn Ala
65                  70                  75                  80  
Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln
                85                  90                  95      
Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asn Asp Thr Ala Ile Tyr
            100                 105                 110         
Tyr Cys Ala Arg Asn Trp Gly Arg Tyr Gly Tyr Phe Asp Val Trp Gly
        115                 120                 125             
Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser
    130                 135                 140                 
Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val
145                 150                 155                 160 
Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val
                165                 170                 175     
Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
            180                 185                 190         
Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro
        195                 200                 205             
Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro
    210                 215                 220                 
Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly
225                 230                 235                 240 
Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile
                245                 250                 255     
Phe
    


<210> 13
<211> 238
<212> PRT
<213> Mus musculus

<220>
<223> mAB 12D1 LC sequence comprising variable region

<400> 13
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala
            20                  25                  30          
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser
        35                  40                  45              
Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro
    50                  55                  60                  
Gly Gln Pro Pro Lys Val Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser
65                  70                  75                  80  
Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr
                85                  90                  95      
Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys
            100                 105                 110         
Gln Gln Ser Asn Gly Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu
        115                 120                 125             
Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro
    130                 135                 140                 
Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly
                165                 170                 175     
Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp
        195                 200                 205             
Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr
    210                 215                 220                 
Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
225                 230                 235             


<210> 14
<211> 765
<212> DNA
<213> Mus musculus

<220>
<223> mAB 66A6 HC sequence comprising variable region

<400> 14
aagcttgcca ccatggaaac cgataccctg ctgctgtggg tgctgctgct gtgggtgccg 60
ggcagctggg cgcaggtgca gctgcagcag agcggcccgg aactgaaaaa accgggcgaa 120
accgtgaaaa ttagctgcaa agcgagcggc tataccttta ccaactatgg catgaactgg 180
gtgaaacagg cgccgggcaa agatctgaaa tggctgggct ggattaacac cgataccggc 240
gaaccgacct atgcggaaga atttaaaggc cgctttgcgt ttagcctgga aaccagcgcg 300
agcaccgcgt atctggaaat taacaacctg aaaaacgaag atgcggcgac ctatttttgc 360
gcgcgcaaca aaaaatatga agcgtggttt acccattggg gccagggcac cctggtgacc 420
gtgagcagcg cgaaaaccac cccgccgagc gtgtatccgc tggcgccggg cagcgcggcg 480
cagaccaaca gcatggtgac cctgggctgc ctggtgaaag gctattttcc ggaaccggtg 540
accgtgacct ggaacagcgg cagcctgagc agcggcgtgc atacctttcc ggcggtgctg 600
cagagcgatc tgtataccct gagcagcagc gtgaccgtgc cgagcagcac ctggccgagc 660
cagaccgtga cctgcaacgt ggcgcatccg gcgagcagca ccaaagtgga taaaaaaatt 720
gtgccgcgcg attgcggcca tcatcatcat catcattaag aattc                 765

<210> 15
<211> 731
<212> DNA
<213> Mus musculus

<220>
<223> mAB 66A6 LC sequence comprising variable region

<400> 15
aagcttgcca ccatggaaac cgataccctg ctgctgtggg tgctgctgct gtgggtgccg 60
ggcagcaccg ggaacattgt gctgacccag agcccggcga gcctggcggt gagcctgggc 120
cagcgcgcga ccattagctg caaagcgagc gaaagcgtgg atagctatgg caccagcttt 180
atgcattggt atcagcagaa accgggccag ccgccgaaac tgctgattta tctggcgagc 240
aacctggaaa gcggcgtgcc ggcgcgcttt agcggcagcg gcagccgcac cgattttacc 300
ctgaccattg atccggtgga agcggatgat gcggcgacct attattgcca gcagaacaac 360
gaacatccga tgtttggcgg cggcaccaaa ctggaaatta aacgcgcgga tgcggcgccg 420
accgtgagca tttttccgcc gagcagcgaa cagctgacca gcggcggcgc gagcgtggtg 480
tgctttctga acaactttta tccgaaagat attaacgtga aatggaaaat tgatggcagc 540
gaacgccaga acggcgtgct gaacagctgg accgatcagg atagcaaaga tagcacctat 600
agcatgagca gcaccctgac cctgaccaaa gatgaatatg aacgccataa cagctatacc 660
tgcgaagcga cccataaaac cagcaccagc ccgattgtga agagctttaa ccgcaacgaa 720
tgctaagaat t                                                      731

<210> 16
<211> 247
<212> PRT
<213> Mus musculus

<220>
<223> mAB 66A6 HC sequence comprising variable region

<400> 16
Ser Lys Leu Ala Thr Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu
 1               5                  10                  15      
Leu Leu Trp Val Pro Gly Ser Trp Ala Gln Val Gln Leu Gln Gln Ser
            20                  25                  30          
Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys
        35                  40                  45              
Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln
    50                  55                  60                  
Ala Pro Gly Lys Asp Leu Lys Trp Leu Gly Trp Ile Asn Thr Asp Thr
65                  70                  75                  80  
Gly Glu Pro Thr Tyr Ala Glu Glu Phe Lys Gly Arg Phe Ala Phe Ser
                85                  90                  95      
Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Glu Ile Asn Asn Leu Lys
            100                 105                 110         
Asn Glu Asp Ala Ala Thr Tyr Phe Cys Ala Arg Asn Lys Lys Tyr Glu
        115                 120                 125             
Ala Trp Phe Thr His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
    130                 135                 140                 
Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala
145                 150                 155                 160 
Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr
                165                 170                 175     
Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser
            180                 185                 190         
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu
        195                 200                 205             
Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val
    210                 215                 220                 
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys
225                 230                 235                 240 
Ile Val Pro Arg Asp Cys Gly
                245         


<210> 17
<211> 242
<212> PRT
<213> Mus musculus

<220>
<223> mAB 66A6 LC sequence comprising variable region

<400> 17
Ser Lys Leu Ala Thr Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu
 1               5                  10                  15      
Leu Leu Trp Val Pro Gly Ser Thr Gly Asn Ile Val Leu Thr Gln Ser
            20                  25                  30          
Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys
        35                  40                  45              
Lys Ala Ser Glu Ser Val Asp Ser Tyr Gly Thr Ser Phe Met His Trp
    50                  55                  60                  
Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala
65                  70                  75                  80  
Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser
                85                  90                  95      
Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Ala
            100                 105                 110         
Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Glu His Pro Met Phe Gly Gly
        115                 120                 125             
Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser
    130                 135                 140                 
Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val
145                 150                 155                 160 
Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp
                165                 170                 175     
Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr
            180                 185                 190         
Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr
        195                 200                 205             
Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala
    210                 215                 220                 
Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn
225                 230                 235                 240 
Glu Cys
        


<210> 18
<211> 75
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region FR1

<400> 18
gatgtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc ccggaaactc 60
tcctgtgcag cctct                                                  75

<210> 19
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region FR2

<400> 19
atgcactggg ttcgtcaggc tccagagaag gggctggagt gggtcgcata c          51

<210> 20
<211> 114
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region FR3

<400> 20
tactatgcag acacagtgaa gggccgattc accatctcca gagacaatcc caagaacacc 60
ctgttcctgc aaatgaccag tctaaggtct gaggacacgg ccatgtatta ctgt       114

<210> 21
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region FR4

<400> 21
tggggcgcag ggaccacggt caccgtctcc tcagcc                           36

<210> 22
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region CDR1

<400> 22
ggattcactt tcagtagctt tgga                                        24

<210> 23
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region CDR2

<400> 23
attagtagtg gcagtagtac catc                                        24

<210> 24
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region CDR3

<400> 24
gcaagaaatt acgacgagga cttcgatgtc                                  30

<210> 25
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region leader sequence

<400> 25
atggactcca ggctcaattt agttttcctt gtccttattt taaaaggtgt ccagtgt    57

<210> 26
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region FR1

<400> 26
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc 60
atctcttgca gatctagt                                               78

<210> 27
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region FR2

<400> 27
ttacattggt acctgcagaa gccaggccag tctccaaagc tcctgatcta c          51

<210> 28
<211> 108
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region FR3

<400> 28
aaccgatttt ctggggtccc agacaggttc agtggcagtg gatcagggac agatttcaca 60
ctcaagatca gcagagtgga ggctgaggat ctgggagttt atttctgc              108

<210> 29
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region FR4

<400> 29
ttcggtggag gcaccaagct ggaaatcaaa cgggct                           36

<210> 30
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region CDR1

<400> 30
cagagccttg tacacagtaa tggaaacacc tat                              33

<210> 31
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region CDR2

<400> 31
aaagtttcc                                                         9

<210> 32
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region CDR3

<400> 32
tctcaaagta cacatgttcc gtggacg                                     27

<210> 33
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region leader sequence

<400> 33
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagt    57

<210> 34
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region FR1

<400> 34
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Arg Lys Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 35
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region FR2

<400> 35
Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ala
 1               5                  10                  15      
Tyr
    


<210> 36
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region FR3

<400> 36
Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
 1               5                  10                  15      
Pro Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp
            20                  25                  30          
Thr Ala Met Tyr Tyr Cys
        35              


<210> 37
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region FR4

<400> 37
Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala
 1               5                  10          


<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region CDR1

<400> 38
Gly Phe Thr Phe Ser Ser Phe Gly
 1               5              


<210> 39
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region CDR2

<400> 39
Ile Ser Ser Gly Ser Ser Thr Ile
 1               5              


<210> 40
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region CDR3

<400> 40
Ala Arg Asn Tyr Asp Glu Asp Phe Asp Val
 1               5                  10  


<210> 41
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region leader sequence

<400> 41
Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Ile Leu Lys Gly
 1               5                  10                  15      
Val Gln Cys
            


<210> 42
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region FR1

<400> 42
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser
            20                  25      


<210> 43
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region FR2

<400> 43
Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
 1               5                  10                  15      
Tyr
    


<210> 44
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region FR3

<400> 44
Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly
 1               5                  10                  15      
Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly
            20                  25                  30          
Val Tyr Phe Cys
        35      


<210> 45
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region FR4

<400> 45
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala
 1               5                  10          


<210> 46
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region CDR1

<400> 46
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr
 1               5                  10      


<210> 47
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region CDR2

<400> 47
Lys Val Ser
 1          


<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region CDR3

<400> 48
Ser Gln Ser Thr His Val Pro Trp Thr
 1               5                  


<210> 49
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region leader sequence

<400> 49
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala
 1               5                  10                  15      
Ser Ser Ser
            


<210> 50
<211> 75
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region FR1

<400> 50
caggtgcacc tggagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 60
acctgcacag tctct                                                  75

<210> 51
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region FR2

<400> 51
gtacactggg ttcgccagtc tccaggaaag ggtctggagt ggctgggagt g          51

<210> 52
<211> 114
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region FR3

<400> 52
gactataatg cagctttcat atccagactg agcatcagca aggacaattc caagagccaa 60
gttttcttta aaatgaacag tctgcaagct aatgacacag ccatatatta ctgt       114

<210> 53
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region FR4

<400> 53
tggggcgcag ggaccacggt caccgtctcc tcagcc                           36

<210> 54
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region CDR1

<400> 54
ggtttctcat taacaacgta tggt                                        24

<210> 55
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region CDR2

<400> 55
atatggagag gtggaagcat a                                           21

<210> 56
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region CDR3

<400> 56
gccagaaatt ggggtaggta cggatacttc gatgtc                           36

<210> 57
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region leader sequence

<400> 57
atggctgtct tggggctgct cttctgcctg gtgacattcc caagctgtgt cctatcc    57

<210> 58
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region FR1

<400> 58
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc 60
atatcctgca gagccagt                                               78

<210> 59
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region FR2

<400> 59
atgcactggt accagcagaa accaggacag ccacccaaag tcctcatcta t          51

<210> 60
<211> 108
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region FR3

<400> 60
aacctagaat ctgggatccc tgccaggttc agtggcagtg ggtctaggac agacttcacc 60
ctcaccatta atcctgtgga ggctgatgat gttgcaacct attactgt              108

<210> 61
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region FR4

<400> 61
ttcggtggag gcaccaagct ggaaatcaaa cgggct                           36

<210> 62
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region CDR1

<400> 62
gaaagtgttg atagttatgg caacagtttt                                  30

<210> 63
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region CDR2

<400> 63
cgtgcatcc                                                         9

<210> 64
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region CDR3

<400> 64
cagcaaagta atggggatcc tcggacg                                     27

<210> 65
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region leader sequence

<400> 65
atggagacag acacactcct gctatgggtg ctgctgctct gggttccagg ttccacaggt 60


<210> 66
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region FR1

<400> 66
Gln Val His Leu Glu Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser
            20                  25  


<210> 67
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region FR2

<400> 67
Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly
 1               5                  10                  15      
Val
    


<210> 68
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> - mAB 12D1 HC variable region FR3

<400> 68
Asp Tyr Asn Ala Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn
 1               5                  10                  15      
Ser Lys Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asn Asp
            20                  25                  30          
Thr Ala Ile Tyr Tyr Cys
        35              


<210> 69
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region FR4

<400> 69
Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala
 1               5                  10          


<210> 70
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region CDR1

<400> 70
Gly Phe Ser Leu Thr Thr Tyr Gly
 1               5              


<210> 71
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region CDR2

<400> 71
Ile Trp Arg Gly Gly Ser
 1               5      


<210> 72
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region CDR3

<400> 72
Ala Arg Asn Trp Gly Arg Tyr Gly Tyr Phe Asp Val
 1               5                  10          


<210> 73
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region leader sequence

<400> 73
Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys
 1               5                  10                  15      
Val Leu Ser
            


<210> 74
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region FR1

<400> 74
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser
            20                  25      


<210> 75
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region FR2

<400> 75
Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Val Leu Ile
 1               5                  10                  15      
Tyr
    


<210> 76
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region FR3

<400> 76
Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg
 1               5                  10                  15      
Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala
            20                  25                  30          
Thr Tyr Tyr Cys
        35      


<210> 77
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region FR4

<400> 77
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala
 1               5                  10          


<210> 78
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region CDR1

<400> 78
Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe
 1               5                  10  


<210> 79
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region CDR2

<400> 79
Arg Ala Ser
 1          


<210> 80
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region CDR3

<400> 80
Gln Gln Ser Asn Gly Asp Pro Arg Thr
 1               5                  


<210> 81
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region leader sequence

<400> 81
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly
            20  


<210> 82
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region CDR1

<400> 82
ggctatacct ttaccaacta tggc                                        24

<210> 83
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region CDR2

<400> 83
attaacaccg ataccggcga accg                                        24

<210> 84
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region CDR3

<400> 84
gcgcgcaaca aaaaatatga agcgtggttt acccat                           36

<210> 85
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region CDR1

<400> 85
gaaagcgtgg atagctatgg caccagcttt                                  30

<210> 86
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region CDR2

<400> 86
ctggcgagc                                                         9

<210> 87
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region CDR3

<400> 87
cagcagaaca acgaacatcc gatg                                        24

<210> 88
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region FR1

<400> 88
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser
            20                  25  


<210> 89
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region FR2

<400> 89
Met Asn Trp Val Lys Gln Ala Pro Gly Lys Asp Leu Lys Trp Leu Gly
 1               5                  10                  15      
Trp
    


<210> 90
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region FR3

<400> 90
Thr Tyr Ala Glu Glu Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr
 1               5                  10                  15      
Ser Ala Ser Thr Ala Tyr Leu Glu Ile Asn Asn Leu Lys Asn Glu Asp
            20                  25                  30          
Ala Ala Thr Tyr Phe Cys
        35              


<210> 91
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region FR4

<400> 91
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala
 1               5                  10          


<210> 92
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region CDR1

<400> 92
Gly Tyr Thr Phe Thr Asn Tyr Gly
 1               5              


<210> 93
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region CDR2

<400> 93
Ile Asn Thr Asp Thr Gly Glu Pro
 1               5              


<210> 94
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region CDR3

<400> 94
Ala Arg Asn Lys Lys Tyr Glu Ala Trp Phe Thr His
 1               5                  10          


<210> 95
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region leader sequence

<400> 95
Ser Lys Leu Ala Thr Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu
 1               5                  10                  15      
Leu Leu Trp Val Pro Gly Ser Trp Ala
            20                  25  


<210> 96
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region FR1

<400> 96
Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser
            20                  25      


<210> 97
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region FR2

<400> 97
Gly Thr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
 1               5                  10                  15      
Lys Leu Leu Ile Tyr
            20      


<210> 98
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region FR3

<400> 98
Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg
 1               5                  10                  15      
Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Ala Ala
            20                  25                  30          
Thr Tyr Tyr Cys
        35      


<210> 99
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region FR4

<400> 99
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala
 1               5                  10          


<210> 100
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region CDR1

<400> 100
Glu Ser Val Asp Ser Tyr
 1               5      


<210> 101
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region CDR2

<400> 101
Leu Ala Ser
 1          


<210> 102
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region CDR3

<400> 102
Gln Gln Asn Asn Glu His Pro Met
 1               5              


<210> 103
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region leader sequence

<400> 103
Ser Lys Leu Ala Thr Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu
 1               5                  10                  15      
Leu Leu Trp Val Pro Gly Ser Thr Gly
            20                  25  


<210> 104
<211> 75
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region FR1

<400> 104
caggtgcagc tgcagcagag cggcccggaa ctgaaaaaac cgggcgaaac cgtgaaaatt 60
agctgcaaag cgagc                                                  75

<210> 105
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region FR2

<400> 105
atgaactggg tgaaacaggc gccgggcaaa gatctgaaat ggctgggctg g          51

<210> 106
<211> 114
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region FR3

<400> 106
acctatgcgg aagaatttaa aggccgcttt gcgtttagcc tggaaaccag cgcgagcacc 60
gcgtatctgg aaattaacaa cctgaaaaac gaagatgcgg cgacctattt ttgc       114

<210> 107
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region FR4

<400> 107
tggggccagg gcaccctggt gaccgtgagc agcgcg                           36

<210> 108
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region FR1

<400> 108
aacattgtgc tgacccagag cccggcgagc ctggcggtga gcctgggcca gcgcgcgacc 60
attagctgca aagcgagc                                               78

<210> 109
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region FR2

<400> 109
atgcattggt atcagcagaa accgggccag ccgccgaaac tgctgattta t          51

<210> 110
<211> 108
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region FR3

<400> 110
aacctggaaa gcggcgtgcc ggcgcgcttt agcggcagcg gcagccgcac cgattttacc 60
ctgaccattg atccggtgga agcggatgat gcggcgacct attattgc              108

<210> 111
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region FR4

<400> 111
tttggcggcg gcaccaaact ggaaattaaa cgcgcg                           36

<210> 112
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region

<400> 112
gatgtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc ccggaaactc 60
tcctgtgcag cctctggatt cactttcagt agctttggaa tgcactgggt tcgtcaggct 120
ccagagaagg ggctggagtg ggtcgcatac attagtagtg gcagtagtac catctactat 180
gcagacacag tgaagggccg attcaccatc tccagagaca atcccaagaa caccctgttc 240
ctgcaaatga ccagtctaag gtctgaggac acggccatgt attactgtgc aagaaattac 300
gacgaggact tcgatgtctg gggcgcaggg accacggtca ccgtctcctc agcc       354

<210> 113
<211> 342
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region

<400> 113
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc 60
atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg 120
tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt 180
tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc 240
agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg 300
tggacgttcg gtggaggcac caagctggaa atcaaacggg ct                    342

<210> 114
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 HC variable region

<400> 114
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asn Tyr Asp Glu Asp Phe Asp Val Trp Gly Ala Gly Thr Thr
            100                 105                 110         
Val Thr Val Ser Ser Ala
        115             


<210> 115
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 7A7 LC variable region

<400> 115
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
                85                  90                  95      
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg Ala
        


<210> 116
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region

<400> 116
caggtgcacc tggagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 60
acctgcacag tctctggttt ctcattaaca acgtatggtg tacactgggt tcgccagtct 120
ccaggaaagg gtctggagtg gctgggagtg atatggagag gtggaagcat agactataat 180
gcagctttca tatccagact gagcatcagc aaggacaatt ccaagagcca agttttcttt 240
aaaatgaaca gtctgcaagc taatgacaca gccatatatt actgtgccag aaattggggt 300
aggtacggat acttcgatgt ctggggcgca gggaccacgg tcaccgtctc ctcagcc    357

<210> 117
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region

<400> 117
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc 60
atatcctgca gagccagtga aagtgttgat agttatggca acagttttat gcactggtac 120
cagcagaaac caggacagcc acccaaagtc ctcatctatc gtgcatccaa cctagaatct 180
gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat 240
cctgtggagg ctgatgatgt tgcaacctat tactgtcagc aaagtaatgg ggatcctcgg 300
acgttcggtg gaggcaccaa gctggaaatc aaacgggct                        339

<210> 118
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 HC variable region

<400> 118
Gln Val His Leu Glu Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Arg Gly Gly Ser Ile Asp Tyr Asn Ala Ala Phe Ile
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ala Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Asn Trp Gly Arg Tyr Gly Tyr Phe Asp Val Trp Gly Ala Gly Thr
            100                 105                 110         
Thr Val Thr Val Ser Ser Ala
        115                 


<210> 119
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 12D1 LC variable region

<400> 119
Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln
 1               5                  10                  15      
Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly
            20                  25                  30          
Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys
        35                  40                  45              
Val Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg
    50                  55                  60                  
Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro
65                  70                  75                  80  
Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Gly
                85                  90                  95      
Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala
            100                 105                 110         


<210> 120
<211> 359
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region

<400> 120
aggtgcagct gcagcagagc ggcccggaac tgaaaaaacc gggcgaaacc gtgaaaatta 60
gctgcaaagc gagcggctat acctttacca actatggcat gaactgggtg aaacaggcgc 120
cgggcaaaga tctgaaatgg ctgggctgga ttaacaccga taccggcgaa ccgacctatg 180
cggaagaatt taaaggccgc tttgcgttta gcctggaaac cagcgcgagc accgcgtatc 240
tggaaattaa caacctgaaa aacgaagatg cggcgaccta tttttgcgcg cgcaacaaaa 300
aatatgaagc gtggtttacc cattggggcc agggcaccct ggtgaccgtg agcagcgcg  359

<210> 121
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region

<400> 121
aacattgtgc tgacccagag cccggcgagc ctggcggtga gcctgggcca gcgcgcgacc 60
attagctgca aagcgagcga aagcgtggat agctatggca ccagctttat gcattggtat 120
cagcagaaac cgggccagcc gccgaaactg ctgatttatc tggcgagcaa cctggaaagc 180
ggcgtgccgg cgcgctttag cggcagcggc agccgcaccg attttaccct gaccattgat 240
ccggtggaag cggatgatgc ggcgacctat tattgccagc agaacaacga acatccgatg 300
tttggcggcg gcaccaaact ggaaattaaa cgcgcg                           336

<210> 122
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 HC variable region

<400> 122
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Asp Leu Lys Trp Leu
        35                  40                  45              
Gly Trp Ile Asn Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Glu Ile Asn Asn Leu Lys Asn Glu Asp Ala Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Asn Lys Lys Tyr Glu Ala Trp Phe Thr His Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala
        115                 120 


<210> 123
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAB 66A6 LC variable region

<400> 123
Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Glu Ser Val Asp Ser Tyr
            20                  25                  30          
Gly Thr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65                  70                  75                  80  
Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn
                85                  90                  95      
Glu His Pro Met Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala
            100                 105                 110         


<210> 124
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acids 76 to 106 of the hemagglutinin
      polypeptide of Influenza strain A/Hong Kong/1/1968
      (H3) numbered with classical numbering system

<400> 124
Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu
 1               5                  10                  15      
Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His
            20                  25                  30      


<210> 125
<211> 55
<212> PRT
<213> Artificial Sequence

<220> 
<223> The long alpha helix domain of the hemagglutinin
      polypeptide of Influenza strain A/Hong Kong/1/1968
      (H3)

<400> 125
Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu
 1               5                  10                  15      
Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr
            20                  25                  30          
Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Arg
        35                  40                  45              
Arg Gln Leu Arg Glu Asn Ala
    50                  55  

