                         SEQUENCE LISTING

<110>  CELLECTIS
       CHOULIKA Andr
       CEDRONE Frdric
       SMITH Julianne	
 
<120>  MEGANUCLEASE VARIANTS CLEAVING THE GENOME OF A PATHOGENIC 
       NON-INTEGRATING VIRUS AND USES THEREOF

<130>  F1546 -38 PCT

<160>  814

<170>  PatentIn version 3.3

<210>  1
<211>  163
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  1

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser 
            20                  25                  30          


Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys 
145                 150                 155                 160 


Ser Ser Pro 
            


<210>  2
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  C1221 target

<400>  2
tcaaaacgtc gtacgacgtt ttga                                            24


<210>  3
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  I-CreI  N75

<400>  3

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  4
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  10AAA_P

<400>  4
tcaaaacgtc gacggacgtt ttga                                            24


<210>  5
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  10AGG_P

<400>  5
tcaggacgtc gtacgacgtt ttga                                            24


<210>  6
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5CAC_P

<400>  6
tcaaaaccac gtacgtggtt ttga                                            24


<210>  7
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5GCC_P

<400>  7
tcaaaacgcc gtacggcgtt ttga                                            24


<210>  8
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_2.1

<400>  8
ataaactcac acacggcgtc ctcg                                            24


<210>  9
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_2.2

<400>  9
ataaactcac gtacggcgtc ctcg                                            24


<210>  10
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_2.3

<400>  10
ataaactcac acacgtgagt ttat                                            24


<210>  11
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_2.4

<400>  11
ccaggacgcc gtacggcgtc ctgg                                            24


<210>  12
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_2.5

<400>  12
ataaactcac acacgtgagt ttat                                            24


<210>  13
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_2.6

<400>  13
ccaggacgcc acacggcgtc ctgg                                            24


<210>  14
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  10AAG_P

<400>  14
tcaagacgtc gtacgacgtc ttga                                            24


<210>  15
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  10ACT_P

<400>  15
tcactacgtc gtacgacgta gtga                                            24


<210>  16
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5CAG_P

<400>  16
tcaaaaccag gtacctggtt ttga                                            24


<210>  17
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_4

<400>  17
ccaagctggt gtacctgata gtgg                                            24


<210>  18
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_4.3

<400>  18
ccaagctggt gtacaccagc ttgg                                            24


<210>  19
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_4.4

<400>  19
ccactatcag gtacctgata gtgg                                            24


<210>  20
<400>  20
000

<210>  21
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_13

<400>  21
atgttccccg tctccatgtc cagg                                            24


<210>  22
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_14

<400>  22
ctcttcttcg tcttcggggg tcgc                                            24


<210>  23
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_1

<400>  23
atgggacgtc gtaagggggc ctgg                                            24


<210>  24
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_2

<400>  24
ataaactcac acacggcgtc ctgg                                            24


<210>  25
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  HSV12.3-M1

<400>  25

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  26
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  HSV12.4-ME-132V

<400>  26

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Ile Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Ser Ala Ala Asp 
                165         


<210>  27
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  HSV12.3-M1-80K

<400>  27

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  28
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  HSV13-3-M15-19S

<400>  28

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Arg Leu Lys Leu Thr Leu Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Gly 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  29
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  HSV13-4-MD

<400>  29

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Glu Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Asp Leu Ser 
65                  70                  75                  80  


Gly Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  30
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  HSV13-3-M16-19S

<400>  30

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Arg Leu Lys Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Gly 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  31
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  HSV14.3-MA-19S

<400>  31

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Cys Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  32
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  HSV14.4 -MB

<400>  32

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Arg Leu Thr Leu Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Val Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  33
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  HSV2.3-M1

<400>  33

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  34
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  HSV2.4-MC

<400>  34

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  35
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  HSV4.3 optimised variant

<400>  35

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  36
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  HSV4.4 optimised variant

<400>  36

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Gly Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Ala Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165         


<210>  37
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5GGT_P

<400>  37
tcaaaacggt gtacaccgtt ttga                                            24


<210>  38
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV2.3 OLIGO

<400>  38
tggcatacaa gtttataaac tcacgtacgt gagtttatca atcgtctgtc a              51


<210>  39
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV2.5 OLIGO

<400>  39
tggcatacaa gtttataaac tcacacacgt gagtttatca atcgtctgtc a              51


<210>  40
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 1

<400>  40

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  41
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 2

<400>  41

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Arg Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  42
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  TableVIII variant 3

<400>  42

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Arg Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  43
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 4

<400>  43

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gln Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  44
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  TableVIII variant 5

<400>  44

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  45
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 6

<400>  45

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  46
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 7

<400>  46

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  47
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 8

<400>  47

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  48
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 9

<400>  48

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  49
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 10

<400>  49

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  50
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 11

<400>  50

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Asn Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  51
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 12

<400>  51

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  52
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 13

<400>  52

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  53
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 14

<400>  53

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Thr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  54
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 15

<400>  54

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  55
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 16

<400>  55

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  56
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 17

<400>  56

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Leu Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  57
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 18

<400>  57

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Thr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Lys Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  58
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 19

<400>  58

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  59
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 20

<400>  59

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  60
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 21

<400>  60

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  61
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 22

<400>  61

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  62
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 23

<400>  62

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  63
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 24

<400>  63

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  64
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 25

<400>  64

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  65
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 26

<400>  65

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Lys Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  66
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 27

<400>  66

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  67
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 28

<400>  67

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  68
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 29

<400>  68

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  69
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 30

<400>  69

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  70
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 31

<400>  70

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  71
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 1

<400>  71

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  72
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 2

<400>  72

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  73
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 3

<400>  73

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  74
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 4

<400>  74

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  75
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 5

<400>  75

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Thr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Lys Tyr Glu Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  76
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 6

<400>  76

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Lys Tyr Glu Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  77
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 7

<400>  77

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  78
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 8

<400>  78

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  79
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 9

<400>  79

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  80
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 10

<400>  80

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  81
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 11

<400>  81

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  82
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 12

<400>  82

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  83
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 13

<400>  83

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  84
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 14

<400>  84

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  85
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 15

<400>  85

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Thr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  86
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 16

<400>  86

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  87
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 17

<400>  87

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  88
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 18

<400>  88

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  89
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 19

<400>  89

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  90
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table IX variant 20

<400>  90

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Gln Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  91
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV2.4 OLIGO

<400>  91
tggcatacaa gtttccagga cgccgtacgg cgtcctggca atcgtctgtc a              51


<210>  92
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV2.6 OLIGO

<400>  92
tggcatacaa gtttccagga cgccacacgg cgtcctggca atcgtctgtc a              51


<210>  93
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 1

<400>  93

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  94
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 2

<400>  94

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  95
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 3

<400>  95

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  96
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 4

<400>  96

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  97
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 5

<400>  97

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  98
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 6

<400>  98

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asp Gln 
            20                  25                  30          


Ser Ala Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  99
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 7

<400>  99

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asp Gln 
            20                  25                  30          


Ser Ala Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  100
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 8

<400>  100

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asp Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Lys Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  101
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 9

<400>  101

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asp Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Lys Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  102
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 10

<400>  102

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asp Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Lys Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  103
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 11

<400>  103

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asp Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Lys Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Thr Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  104
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 12

<400>  104

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asp Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Gly Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  105
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 13

<400>  105

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Ala Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asp Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Gly Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  106
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 14

<400>  106

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asp Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Gly Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  107
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 15

<400>  107

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gly Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  108
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 16

<400>  108

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gly Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  109
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 17

<400>  109

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  110
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 18

<400>  110

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  111
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 19

<400>  111

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  112
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 20

<400>  112

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gly Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  113
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 21

<400>  113

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Asn Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  114
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 22

<400>  114

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gln Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  115
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 23

<400>  115

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  116
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 24

<400>  116

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  117
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 25

<400>  117

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  118
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 26

<400>  118

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  119
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 27

<400>  119

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  120
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 28

<400>  120

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  121
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 29

<400>  121

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  122
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 30

<400>  122

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  123
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 31

<400>  123

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  124
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 32

<400>  124

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gly Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  125
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 33

<400>  125

Met Ala Asn Ala Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gly Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  126
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 34

<400>  126

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  127
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 35

<400>  127

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gln Asp Asp Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  128
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 36

<400>  128

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gln Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  129
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 37

<400>  129

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  130
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 38

<400>  130

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  131
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table X variant 39

<400>  131

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  132
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 1

<400>  132

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Arg Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Val Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Arg Ser Ser Pro Ala Ala Asp 
                165         


<210>  133
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 2

<400>  133

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Ser Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  134
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 3

<400>  134

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gly Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  135
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 4

<400>  135

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Thr Ala Ala Asp 
                165         


<210>  136
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 5

<400>  136

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  137
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 6

<400>  137

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  138
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 7

<400>  138

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  139
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 8

<400>  139

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  140
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 9

<400>  140

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Phe Pro Ala Ala Asp 
                165         


<210>  141
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 10

<400>  141

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  142
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 11

<400>  142

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  143
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 12

<400>  143

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  144
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 13

<400>  144

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  145
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 14

<400>  145

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Val Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  146
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 15

<400>  146

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gln Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  147
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 16

<400>  147

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His His Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  148
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 17

<400>  148

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  149
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 18

<400>  149

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  150
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 19

<400>  150

Met Ala Asn Ala Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gly Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  151
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XI variant 20

<400>  151

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  152
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV2 OLIGO

<400>  152
tggcatacaa gtttataaac tcacacacgg cgtcctggca atcgtctgtc a              51


<210>  153
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.4 variant 1

<400>  153

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Ser Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  154
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.4 variant 2

<400>  154

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  155
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.4 variant 3

<400>  155

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  156
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.4 variant 4

<400>  156

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Thr Ala Ala Asp 
                165         


<210>  157
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.4 variant 5

<400>  157

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gly Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  158
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.4 variant 6

<400>  158

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  159
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.3 variant 1

<400>  159

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  160
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.3 variant 2

<400>  160

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  161
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.3 variant 3

<400>  161

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  162
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.3 variant 4

<400>  162

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  163
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.3 variant 5

<400>  163

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Thr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Lys Tyr Glu Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  164
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.3 variant 6

<400>  164

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  165
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.3 variant 7

<400>  165

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  166
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.3 variant 8

<400>  166

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Thr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Lys Tyr Glu Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  167
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.3 variant 9

<400>  167

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  168
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XII HSV2.3 variant 10

<400>  168

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  169
<211>  59
<212>  DNA
<213>  Artificial

<220>
<223>  preATGCreFor

<400>  169
gcataaatta ctatacttct atagacacgc aaacacaaat acacagcggc cttgccacc      59


<210>  170
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  ICreIpostRev

<400>  170
ggctcgagga gctcgtctag aggatcgctc gagttatcag tcggccgc                  48


<210>  171
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIII variant 1

<400>  171

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  172
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIII variant 2

<400>  172

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  173
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIII variant 3

<400>  173

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  174
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIII variant 4

<400>  174

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  175
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIII variant 5

<400>  175

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Thr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Lys Tyr Glu Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  176
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIII variant 6

<400>  176

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  177
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 1

<400>  177

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  178
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 2

<400>  178

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr His Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  179
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 3

<400>  179

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys Tyr Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Pro Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  180
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 4

<400>  180

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  181
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 5

<400>  181

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Arg Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  182
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 6

<400>  182

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu His Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  183
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 7

<400>  183

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  184
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 8

<400>  184

Met Ala Asp Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys Tyr Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  185
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 9

<400>  185

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys Cys Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  186
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 10

<400>  186

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys Tyr Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  187
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 11

<400>  187

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys Tyr Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  188
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 12

<400>  188

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys Tyr Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Arg Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  189
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 13

<400>  189

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys Tyr Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  190
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 14

<400>  190

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys Tyr Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  191
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 15

<400>  191

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys Tyr Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Arg Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  192
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 16

<400>  192

Met Ala Asn Thr Arg Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Ala Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  193
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 17

<400>  193

Met Ala Asn Thr Arg Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys Tyr Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Ala Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  194
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 18

<400>  194

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Arg 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  195
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 19

<400>  195

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  196
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 20

<400>  196

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys Tyr Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  197
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 21

<400>  197

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  198
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 22

<400>  198

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe His Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Pro Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  199
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 23

<400>  199

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  200
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 24

<400>  200

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Gly Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  201
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 25

<400>  201

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  202
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 26

<400>  202

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  203
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 27

<400>  203

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  204
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 28

<400>  204

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ser Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  205
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 29

<400>  205

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  206
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 30

<400>  206

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Glu Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  207
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 31

<400>  207

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Thr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  208
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XIV variant 32

<400>  208

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  209
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XV variant 1

<400>  209

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Ser Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  210
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XV variant 2

<400>  210

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  211
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XV variant 3

<400>  211

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  212
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XV variant 4

<400>  212

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Thr Ala Ala Asp 
                165         


<210>  213
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XV variant 5

<400>  213

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gly Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  214
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XV variant 6

<400>  214

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  215
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 1

<400>  215

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  216
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 2

<400>  216

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  217
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 3

<400>  217

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  218
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 4

<400>  218

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Ala Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  219
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 5

<400>  219

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  220
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 6

<400>  220

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  221
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 7

<400>  221

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  222
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 8

<400>  222

Met Ala Asp Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Thr Ala Ala Asp 
                165         


<210>  223
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 9

<400>  223

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  224
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 10

<400>  224

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Ser Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  225
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 11

<400>  225

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Ser Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  226
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 12

<400>  226

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Ser Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  227
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 13

<400>  227

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Ser Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  228
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 14

<400>  228

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  229
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 15

<400>  229

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Ser Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  230
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 16

<400>  230

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  231
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 17

<400>  231

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  232
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 18

<400>  232

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Ser Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  233
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVI variant 19

<400>  233

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  234
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.4 variant 1

<400>  234

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  235
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.4 variant 2

<400>  235

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  236
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.4 variant 3

<400>  236

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  237
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.4 variant 4

<400>  237

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  238
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.4 variant 5

<400>  238

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Ala Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  239
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.4 variant 6

<400>  239

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Ser Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  240
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.3 variant 1

<400>  240

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  241
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.3 variant 2

<400>  241

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu His Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  242
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.3 variant 3

<400>  242

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Glu Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  243
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.3 variant 4

<400>  243

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  244
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.3 variant 5

<400>  244

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  245
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.3 variant 6

<400>  245

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Arg Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  246
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVII HSV2.3 variant 7

<400>  246

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  247
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  AT1CA1F

<400>  247
aaaaagcagg ctggcgcgcc tacacagcgg ccttgccacc atg                       43


<210>  248
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  AT2CA2R

<400>  248
agaaagctgg gtgctagcgc tcgagttatc agtcgg                               36


<210>  249
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVIII HSV 2.6 Variant 1

<400>  249

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  250
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVIII HSV 2.6 Variant 2

<400>  250

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Ala Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  251
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVIII HSV 2.5 Variant 1

<400>  251

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  252
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XVIII HSV 2.5 Variant 2

<400>  252

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  253
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV2-M1-MC

<400>  253

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  254
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV2-M1-MC-132V

<400>  254

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  255
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV2-M1-MC-80K132V

<400>  255

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  256
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV2-M1-MC-80K105A132V

<400>  256

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  257
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV2-M1-132V-MC

<400>  257

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  258
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV2-M1-132V-MC-80K105A

<400>  258

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  259
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV2-M1-132V-MC-80K132V

<400>  259

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  260
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV2-M1-132V-MC-80K105A132V

<400>  260

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  261
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV2-M1-105A132V-MC-132V

<400>  261

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  262
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV4.3 OLIGO

<400>  262
tggcatacaa gtttccaagc tggtgtacac cagcttggca atcgtctgtc a              51


<210>  263
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Gal10F

<400>  263

gcaactttag tgctgacaca tacagg					      26
            

<210>  264
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Gal10R

<400>  264
acaaccttga ttggagactt gacc                                            24


<210>  265
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  assF


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  n is a, c, g, or t

<400>  265
ctannnttga ccttt                                                      15


<210>  266
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  assR


<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  n is a, c, g, or t

<400>  266
aaaggtcaan nntag                                                      15


<210>  267
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXII variant 1

<400>  267

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  268
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXII variant 2

<400>  268

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu His Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Cys Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  269
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXII variant 3

<400>  269

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Leu Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  270
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXII variant 4

<400>  270

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  271
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXII variant 5

<400>  271

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  272
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXII variant 6

<400>  272

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  273
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXII variant 7

<400>  273

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  274
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV4.4 OLIGO

<400>  274
tggcatacaa gtttccacta tcaggtacct gatagtggca atcgtctgtc a              51


<210>  275
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 1

<400>  275

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  276
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 2

<400>  276

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Ser Leu Ser Leu Thr Phe Thr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Val Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  277
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 3

<400>  277

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Trp Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Tyr Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  278
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 4

<400>  278

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  279
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 5

<400>  279

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  280
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 6

<400>  280

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Cys Asp Ser Gly Ser Val Ser Tyr Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Val Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  281
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 7

<400>  281

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  282
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 8

<400>  282

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  283
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 9

<400>  283

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ala Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  284
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 10

<400>  284

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  285
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 11

<400>  285

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  286
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 12

<400>  286

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  287
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 13

<400>  287

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  288
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIV variant 14

<400>  288

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  289
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV4 OLIGO

<400>  289
tggcatacaa gtttccaagc tggtgtacct gatagtggca atcgtctgtc a              51


<210>  290
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.4 Variant 1

<400>  290

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  291
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.4 Variant 2

<400>  291

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ala Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  292
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.4 Variant 3

<400>  292

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  293
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.4 Variant 4

<400>  293

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  294
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.4 Variant 5

<400>  294

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  295
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.4 Variant 6

<400>  295

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  296
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.4 Variant 7

<400>  296

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  297
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.4 Variant 8

<400>  297

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Trp Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Tyr Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  298
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.4 Variant 9

<400>  298

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Cys Asp Ser Gly Ser Val Ser Tyr Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Val Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  299
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.3 Variant 1

<400>  299

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Leu Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  300
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.3 Variant 2

<400>  300

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  301
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.3 Variant 3

<400>  301

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  302
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.3 Variant 4

<400>  302

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  303
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.3 Variant 5

<400>  303

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  304
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXV HSV 4.3 Variant 6

<400>  304

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  305
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVI variant 1

<400>  305

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Leu Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  306
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVI variant 2

<400>  306

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  307
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVI variant 3

<400>  307

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  308
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVI variant 4

<400>  308

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  309
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVI variant 5

<400>  309

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  310
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVI variant 6

<400>  310

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  311
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 1

<400>  311

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Leu Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  312
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 2

<400>  312

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Ala Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  313
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 3

<400>  313

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  314
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 4

<400>  314

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Arg Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Leu Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  315
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 5

<400>  315

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Leu Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  316
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 6

<400>  316

Met Ala Asn Thr Asn Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Gln Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  317
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 7

<400>  317

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Arg Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Ser Ala Ala Asp 
                165         


<210>  318
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 8

<400>  318

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Arg Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  319
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 9

<400>  319

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Arg Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  320
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 10

<400>  320

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  321
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 11

<400>  321

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Leu Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  322
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 12

<400>  322

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Arg 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Cys 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Arg Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  323
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 13

<400>  323

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Asp Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  324
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 14

<400>  324

Met Ala Asn Pro Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Glu Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  325
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 15

<400>  325

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asp Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  326
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 16

<400>  326

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  327
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 17

<400>  327

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  328
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 18

<400>  328

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  329
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 19

<400>  329

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Thr Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Gly Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  330
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 20

<400>  330

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Asp Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  331
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 21

<400>  331

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Leu Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  332
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 22

<400>  332

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Val Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Ala Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  333
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 23

<400>  333

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  334
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 24

<400>  334

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  335
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 25

<400>  335

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  336
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 26

<400>  336

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  337
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 27

<400>  337

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  338
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 28

<400>  338

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Val Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  339
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 29

<400>  339

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Glu Ser Ser Pro Ala Ala Asp 
                165         


<210>  340
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 30

<400>  340

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  341
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 31

<400>  341

Met Ala Asn Thr Lys Tyr Asn Arg Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Thr 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Val Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  342
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 32

<400>  342

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Val Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  343
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 33

<400>  343

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  344
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 34

<400>  344

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Glu Ser Val Ser Asn Tyr Met Leu Ser 
65                  70                  75                  80  


Arg Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  345
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 35

<400>  345

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  346
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 36

<400>  346

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Arg Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  347
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 37

<400>  347

Met Ala Tyr Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  348
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 38

<400>  348

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asp Tyr Ile Leu Cys 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Ala Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Val Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  349
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVII variant 39

<400>  349

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  350
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVIII variant 1

<400>  350

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  351
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVIII variant 2

<400>  351

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  352
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVIII variant 3

<400>  352

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  353
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVIII variant 4

<400>  353

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  354
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVIII variant 5

<400>  354

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  355
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVIII variant 6

<400>  355

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  356
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVIII variant 7

<400>  356

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Trp Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Tyr Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  357
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVIII variant 8

<400>  357

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Cys Asp Ser Gly Ser Val Ser Tyr Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Val Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  358
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXVIII variant 9

<400>  358

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  359
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 1

<400>  359

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  360
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 2

<400>  360

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Arg Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  361
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 3

<400>  361

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  362
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 4

<400>  362

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  363
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 5

<400>  363

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Tyr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  364
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 6

<400>  364

Val Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gly Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Ser Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  365
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 7

<400>  365

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Gly Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Ala Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165         


<210>  366
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 8

<400>  366

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Glu Ser Ser Pro Ala Ala Asp 
                165         


<210>  367
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 9

<400>  367

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  368
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 10

<400>  368

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Ile Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  369
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 11

<400>  369

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Gln Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  370
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 12

<400>  370

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Arg Tyr Lys Phe Lys His Glu Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  371
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 13

<400>  371

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  372
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 14

<400>  372

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  373
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 15

<400>  373

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Thr Ala Asp 
                165         


<210>  374
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 16

<400>  374

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Arg Ala Ala Asp 
                165         


<210>  375
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 17

<400>  375

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Met Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Asp Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Gly Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Gln Ala Ala Asp 
                165         


<210>  376
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 18

<400>  376

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165         


<210>  377
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 19

<400>  377

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Asn His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Gly Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Glu Ile Ile Lys Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  378
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 20

<400>  378

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Asn Ser Ser Pro Ala Ala Asp 
                165         


<210>  379
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 21

<400>  379

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Gln Ala Ala Asp 
                165         


<210>  380
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 22

<400>  380

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  381
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 23

<400>  381

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Arg Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  382
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 24

<400>  382

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Ala Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  383
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 25

<400>  383

Met Ala Ser Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  384
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 26

<400>  384

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Gln Asp Ser Leu Ser Glu Glu Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  385
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 27

<400>  385

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  386
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 28

<400>  386

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Ile Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  387
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 29

<400>  387

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Arg Gln Ala Asn Leu Val Leu Lys Ile Ile Gln Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Pro Ser Pro Ala Ala Asp 
                165         


<210>  388
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 30

<400>  388

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Tyr Asp Ser Gly Cys Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Gln Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Arg Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  389
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 31

<400>  389

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asn Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  390
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 32

<400>  390

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Ile Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Leu Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  391
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 33

<400>  391

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Cys Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  392
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 34

<400>  392

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Ala Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  393
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 35

<400>  393

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  394
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 36

<400>  394

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Arg 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  395
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 37

<400>  395

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Thr Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  396
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 38

<400>  396

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  397
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 39

<400>  397

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Lys Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  398
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 40

<400>  398

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Gln Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  399
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 41

<400>  399

Met Ala Asn Ser Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  400
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 42

<400>  400

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Gly Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  401
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 43

<400>  401

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  402
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 44

<400>  402

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Asn His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  403
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 45

<400>  403

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg His 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Ala Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  404
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 46

<400>  404

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  405
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 47

<400>  405

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Ser Ala Ala Asp 
                165         


<210>  406
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 48

<400>  406

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Glu Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  407
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 49

<400>  407

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Tyr Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  408
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 50

<400>  408

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Val Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ala Ser Pro Ala Ala Asp 
                165         


<210>  409
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 51

<400>  409

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Met Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  410
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 52

<400>  410

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Glu Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  411
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 53

<400>  411

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Asn Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  412
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 54

<400>  412

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Ala Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  413
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 55

<400>  413

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Met Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  414
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 56

<400>  414

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  415
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 57

<400>  415

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Glu Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  416
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 58

<400>  416

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Arg Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  417
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 59

<400>  417

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Trp Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Tyr Tyr Tyr Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Asp Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  418
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 60

<400>  418

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Arg Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  419
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 61

<400>  419

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Gly Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  420
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 62

<400>  420

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Glu Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Lys 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Arg Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  421
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXIX variant 63

<400>  421

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Gly 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  422
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXX HSV 4.4 variant 1

<400>  422

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Glu Ser Ser Pro Ala Ala Asp 
                165         


<210>  423
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXX HSV 4.4 variant 2

<400>  423

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Gly Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Ala Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165         


<210>  424
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXX HSV 4.4 variant 3

<400>  424

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  425
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXX HSV 4.4 variant 4

<400>  425

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Arg Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  426
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXX HSV 4.4 variant 5

<400>  426

Val Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gly Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Ser Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  427
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXX HSV 4.4 variant 6

<400>  427

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  428
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXX HSV 4.3 variant 1

<400>  428

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Arg Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  429
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXX HSV 4.3 variant 2

<400>  429

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  430
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXX HSV 4.3 variant 3

<400>  430

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Leu Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  431
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXX HSV 4.3 variant 4

<400>  431

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  432
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXX HSV 4.3 variant 5

<400>  432

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  433
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXX HSV 4.3 variant 6

<400>  433

Met Ala Tyr Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  434
<211>  77
<212>  DNA
<213>  Artificial

<220>
<223>  attB1-ICreIFor

<400>  434
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatgg ccaataccaa     60

atataacaaa gagttcc                                                    77


<210>  435
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  attB2-ICreIRev

<400>  435
ggggaccact ttgtacaaga aagctgggtt tagtcggccg ccggggagga tttcttcttc     60

tcgc                                                                  64


<210>  436
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXXI HSV4.4 optimized variant 1

<400>  436

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Gly Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Ala Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165         


<210>  437
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXXI HSV4.4 optimized variant 2

<400>  437

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Phe Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Arg Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  438
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXXI HSV4.4 optimized variant 3

<400>  438

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Ser Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  439
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXXI HSV4.4 optimized variant 4

<400>  439

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  440
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXXI HSV4.3 optimized variant 1

<400>  440

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Arg Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  441
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXXI HSV4.3 optimized variant 2

<400>  441

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  442
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXXI HSV4.3 optimized variant 3

<400>  442

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Leu Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  443
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXXI HSV4.3 optimized variant 4

<400>  443

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asp Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  444
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXXI HSV4.3 optimized variant 5

<400>  444

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  445
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table XXXI HSV4.3 optimized variant 6

<400>  445

Met Ala Tyr Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  446
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV4-M2-MF

<400>  446

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Glu Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  447
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV4-M2-MF-54L

<400>  447

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Glu Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  448
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV4-M2-MF-132V

<400>  448

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Glu Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  449
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV4-M2-54L-MF

<400>  449

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Glu Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  450
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV4-M2-54L-MF-132V

<400>  450

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Glu Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  451
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV4-M2-54L-MF-80K132V

<400>  451

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Glu Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  452
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV4-M2-105A-MF

<400>  452

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Glu Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  453
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV4-M2-105A-MF-132V

<400>  453

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Glu Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  454
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV4-M2-105A-MF-80K132V

<400>  454

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Glu Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  455
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 32

<400>  455

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Thr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  456
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 33

<400>  456

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  457
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 34

<400>  457

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  458
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 35

<400>  458

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  459
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 36

<400>  459

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Lys Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  460
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 37

<400>  460

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  461
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 38

<400>  461

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  462
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 39

<400>  462

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  463
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table VIII variant 40

<400>  463

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ser Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Arg Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  464
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  peptide linker

<400>  464

Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn 
1               5                   10                  15      


Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly Gly Gly Gly Ser 
            20                  25                  30      

<210>  465
<211>  354
<212>  PRT
<213>  Artificial

<220>  SCOH-HSV12-M1-ME-132V

<400>  465   
Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly
            180                 185                 190


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Ser 
    210                 215                 220


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255               


His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser Glu Ile 
            260                 265                 270


Lys Pro Leu His Asn Ile Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285    


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro
    290                 295                 300              


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320


Asp Gln Val Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335 
   

Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350
 

Ser Ser



<210>  466
<211>  354
<212>  PRT
<213>  Artificial

<220>  SCOH-HSV12-M1-80K-ME-132V

<400>  466    

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly
            180                 185                 190


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Ser 
    210                 215                 220


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255               


His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser Glu Ile 
            260                 265                 270


Lys Pro Leu His Asn Ile Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285    


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro
    290                 295                 300              


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320


Asp Gln Val Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335 
   

Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350
 

Ser Ser
                        

<210>  467
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  I-SceI cleavage site

<400>  467
tagggataac agggtaat                                                   18


<210>  468
<211>  354
<212>  PRT
<213>  Artificial

<220>  SCOH-RAG

<400>  468 

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Asn Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Arg Leu Arg Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Gln Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Gly Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Asn 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 




<210>  469
<211>  237
<212>  PRT
<213>  Artificial

<220>  I-SceI meganuclease

<400>  469

Met Ala Lys Asn Ile Lys Lys Asn Gln Val Met Asn Leu Gly Pro Asn 
1               5                   10                  15      


Ser Lys Leu Leu Lys Glu Tyr Lys Ser Gln Leu Ile Glu Leu Asn Ile 
            20                  25                  30          


Glu Gln Phe Glu Ala Gly Ile Gly Leu Ile Leu Gly Asp Ala Tyr Ile 
        35                  40                  45              


Arg Ser Arg Asp Glu Gly Lys Thr Tyr Cys Met Gln Phe Glu Trp Lys 
    50                  55                  60                  


Asn Lys Ala Tyr Met Asp His Val Cys Leu Leu Tyr Asp Gln Trp Val 
65                  70                  75                  80  


Leu Ser Pro Pro His Lys Lys Glu Arg Val Asn His Leu Gly Asn Leu 
                85                  90                  95      


Val Ile Thr Trp Gly Ala Gln Thr Phe Lys His Gln Ala Phe Asn Lys 
            100                 105                 110         


Leu Ala Asn Leu Phe Ile Val Asn Asn Lys Lys Thr Ile Pro Asn Asn 
        115                 120                 125             


Leu Val Glu Asn Tyr Leu Thr Pro Met Ser Leu Ala Tyr Trp Phe Met 
    130                 135                 140                 


Asp Asp Gly Gly Lys Trp Asp Tyr Asn Lys Asn Ser Thr Asn Lys Ser 
145                 150                 155                 160 


Ile Val Leu Asn Thr Gln Ser Phe Thr Phe Glu Glu Val Glu Tyr Leu 
                165                 170                 175     


Val Lys Gly Leu Arg Asn Lys Phe Gln Leu Asn Cys Tyr Val Lys Ile 
            180                 185                 190         


Asn Lys Asn Lys Pro Ile Ile Tyr Ile Asp Ser Met Ser Tyr Leu Ile 
        195                 200                 205             


Phe Tyr Asn Leu Ile Lys Pro Tyr Leu Ile Pro Gln Met Met Tyr Lys 
    210                 215                 220                 


Leu Pro Asn Thr Ile Ser Ser Glu Thr Phe Leu Lys Ala 
225                 230                 235         


<210>  470
<211>  167
<212>  PRT
<213>  Artificial

<220>  HSV1.3-M5

<400>  470

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  471
<211>  167
<212>  PRT
<213>  Artificial

<220>  
<223>  HSV1.4-MF

<400>  471

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  472
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_1.2

<400>  472
atgggacgtc gtacgggggc ctgg                                            24


<210>  473
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  10GGG_P

<400>  473
tcgggacgtc gtacgacgtc ccga                                            24


<210>  474
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5GTC_P

<400>  474
tcaaaacgtc gtacgacgtt ttga                                            24


<210>  475
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  10AGG_P

<400>  475
tcaggacgtc gtacgacgtc ctga                                            24


<210>  476
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5CCC_P

<400>  476
tcaaaacccc gtacggggtt ttga                                            24


<210>  477
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_1.3

<400>  477
atgggacgtc gtacgacgtc ccat                                            24


<210>  478
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_1.4

<400>  478
ccaggccccc gtacgggggc ctgg                                            24


<210>  479
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_1.5

<400>  479
atgggacgtc gtaagacgtc ccat                                            24


<210>  480
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_1.6

<400>  480
ccaggccccc gtaagggggc ctgg                                            24


<210>  481
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_8.1

<400>  481
ccgctctgtt ttaccgcgtc tacg                                            24


<210>  482
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_8.2

<400>  482
ccgctctgtt gtaccgcgtc tacg                                            24


<210>  483
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  10GCT_P

<400>  483
tcgctacgtc gtacgacgta gcga                                            24


<210>  484
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5GTT_P

<400>  484
tcaaaacgtt gtacaacgtt ttga                                            24


<210>  485
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  10TAG_P

<400>  485
tctagacgtc gtacgacgtc taga                                            24


<210>  486
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5GCG_P

<400>  486
tcaaaacgcg gtaccgcgtt ttga                                            24


<210>  487
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_8.3

<400>  487
ccgctctgtt gtacaacaga gcgg                                            24


<210>  488
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_8.4

<400>  488
cgtagacgcg gtaccgcgtc tacg                                            24


<210>  489
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_8.5

<400>  489
ccgctctgtt ttacaacaga gcgg                                            24


<210>  490
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_8.6

<400>  490
cgtagacgcg ttaccgcgtc tacg                                            24


<210>  491
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_9.1

<400>  491
gcaagaccag gtaaggcagg gggg                                            24


<210>  492
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_9.2

<400>  492
gcaagaccac gtacggcagg gggg                                            24


<210>  493
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  10AAG_P

<400>  493
tcaagacgtc gtacgacgtc ttga                                            24


<210>  494
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5CAC_P

<400>  494
tcaaaaccac gtacgtggtt ttga                                            24


<210>  495
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  10CCC_P

<400>  495
tccccacgtc gtacgacgtg ggga                                            24


<210>  496
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5GCC_P

<400>  496
tcaaaacgcc gtacggcgtt ttga                                            24


<210>  497
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_9.3

<400>  497
gcaagaccag gtacgtggtc ttgc                                            24


<210>  498
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_9.4

<400>  498
cccccctgcc gtacggcagg gggg                                            24


<210>  499
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_9.5

<400>  499
gcaagaccac gtaagtggtc ttgc                                            24


<210>  500
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_9.6

<400>  500
cccccctgcc gtaaggcagg gggg                                            24


<210>  501
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_12.1

<400>  501
cctggacatg gagacgggga acat                                            24


<210>  502
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_12.2

<400>  502
cctggacatg gtaccgggga acat                                            24


<210>  503
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  10TGG_P

<400>  503
tctggacgtc gtacgacgtc caga                                            24


<210>  504
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5ATG_P

<400>  504
tcaaaacatg gtaccatgtt ttga                                            24


<210>  505
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  10GTT_P

<400>  505
tcgttacgtc gtacgacgta acga                                            24


<210>  506
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5CCG_P

<400>  506
tcaaaacccg gtaccgggtt ttga                                            24


<210>  507
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_12.3

<400>  507
cctggacatg gtaccatgtc cagg                                            24


<210>  508
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_12.4

<400>  508
atgttccccg gtaccgggga acat                                            24


<210>  509
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_12.5

<400>  509
cctggacatg gagacatgtc cagg                                            24


<210>  510
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_12.6

<400>  510
atgttccccg gagacgggga acat                                            24


<210>  511
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxx HSV_8.5 / HSV_8.3 cleaving variant 1

<400>  511

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Lys Gln 
            20                  25                  30          


Ser Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  512
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxx HSV_8.5 / HSV_8.3 cleaving variant 2

<400>  512

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Lys Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  513
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxx HSV_8.5 / HSV_8.3 cleaving variant 3

<400>  513

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  514
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxx HSV_8.5 / HSV_8.3 cleaving variant 4

<400>  514

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  515
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxx HSV_8.5 / HSV_8.3 cleaving variant 5

<400>  515

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Lys Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  516
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxx HSV_8.5 / HSV_8.3 cleaving variant 6

<400>  516

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Lys Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  517
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxx HSV_8.6 / HSV_8.4 cleaving variant 1

<400>  517

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ala Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  518
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxx HSV_8.6 / HSV_8.4 cleaving variant 2

<400>  518

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  519
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxx HSV_8.6 / HSV_8.4 cleaving variant 3

<400>  519

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ala Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  520
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxx HSV_8.6 / HSV_8.4 cleaving variant 4

<400>  520

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Thr Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  521
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxx HSV_8.6 / HSV_8.4 cleaving variant 5

<400>  521

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asn Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  522
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxiii HSV_9.5 / HSV_9.3 cleaving variant 1

<400>  522

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  523
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxiii HSV_9.5 / HSV_9.3 cleaving variant 2

<400>  523

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  524
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxiii HSV_9.5 / HSV_9.3 cleaving variant 3

<400>  524

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Arg Lys Phe Lys His Gln Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  525
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxiii HSV_9.5 / HSV_9.3 cleaving variant 4

<400>  525

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  526
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxiii HSV_9.5 / HSV_9.3 cleaving variant 5

<400>  526

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Arg Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  527
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxiii HSV_9.5 / HSV_9.3 cleaving variant 6

<400>  527

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gly Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  528
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxiii HSV_9.6 / HSV_9.4 cleaving variant 1

<400>  528

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  529
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxiii HSV_9.6 / HSV_9.4 cleaving variant 2

<400>  529

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Gly Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Thr Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Arg Pro Phe Leu 
                85                  90                  95      


Arg Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Arg Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  530
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxiii HSV_9.6 / HSV_9.4 cleaving variant 3

<400>  530

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Glu Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  531
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxiii HSV_9.6 / HSV_9.4 cleaving variant 4

<400>  531

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Asn Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  532
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV2-M1-MC-80K105A132VRev1

<400>  532

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Arg Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  533
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV2-M1-MC-80K105A132VRev1 (2)

<400>  533

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Arg Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asp Tyr Ile Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  534
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV4-M2-105A-MF-80K132V

<400>  534

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Met Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Lys Thr Val Arg Ala Val Leu Asp Ser Leu Gly Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Glu Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  535
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-132V-MF

<400>  535

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Trp Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  536
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  gB Forward primer

<400>  536
agaaagcccc cattggccag gtagt                                           25


<210>  537
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  gB Reverse primer

<400>  537
attctcttcc gacgccatat ccaccac                                         27


<210>  538
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  GAPDH Forward primer

<400>  538
ggcagaaccc gggtttataa ctgtc                                           25


<210>  539
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  GAPDH reverse primer

<400>  539
ccagtcctgg atgagaaagg                                                 20


<210>  540
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_1 target oligo

<400>  540
tggcatacaa gtttatggga cgtcgtaagg gggcctggca atcgtctgtc                50


<210>  541
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.5 / HSV_1.3 cleaving variant 1

<400>  541

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  542
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.5 / HSV_1.3 cleaving variant 2

<400>  542

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  543
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.5 / HSV_1.3 cleaving variant 3

<400>  543

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Glu Pro Asn Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Arg Leu Lys Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  544
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.5 / HSV_1.3 cleaving variant 4

<400>  544

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Leu Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  545
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.5 / HSV_1.3 cleaving variant 5

<400>  545

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  546
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.5 / HSV_1.3 cleaving variant 6

<400>  546

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  547
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.5 / HSV_1.3 cleaving variant 7

<400>  547

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Pro Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  548
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.5 / HSV_1.3 cleaving variant 8

<400>  548

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Ser Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Gly Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  549
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.6 / HSV_1.4 cleaving variant 1

<400>  549

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  550
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.6 / HSV_1.4 cleaving variant 2

<400>  550

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  551
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.6 / HSV_1.4 cleaving variant 3

<400>  551

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Ser Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  552
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.6 / HSV_1.4 cleaving variant 4

<400>  552

Met Ala Asn Thr Lys Tyr Asn Lys Glu Tyr Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  553
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.6 / HSV_1.4 cleaving variant 5

<400>  553

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  554
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxvii HSV_1.6 / HSV_1.4 cleaving variant 6

<400>  554

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Trp Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  555
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_1 target + gateway seqs

<400>  555
tggcatacaa gtttatggga cgtcgtaagg gggcctggca atcgtctgtc a              51


<210>  556
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-MF

<400>  556

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  557
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-MF-132V

<400>  557

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  558
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-MF-80K105A

<400>  558

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  559
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-MF-80K132V

<400>  559

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  560
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-MF-80K105A132V

<400>  560

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  561
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-132V-MF

<400>  561

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  562
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-132V-MF-132V

<400>  562

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  563
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-80K105A-MF

<400>  563

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  564
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-80K132V-MF

<400>  564

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  565
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-80K132V-MF-105A

<400>  565

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  566
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-80K132V-MF-132V

<400>  566

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  567
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-80K132V-MF-80K105A

<400>  567

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Glu Gly Ser Val Ser Asn Tyr Ile Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  568
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV1-M5-MFrev

<400>  568

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Thr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Pro Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  569
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_8 target + gateway seqs

<400>  569
tggcatacaa gtttccgctc tgttttaccg cgtctacgca atcgtctgtc a              51


<210>  570
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_8 target + gateway seqs

<400>  570
tggcatacaa gtttccgctc tgttttaccg cgtctacgca atcgtctgtc a              51


<210>  571
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV8b1-A

<400>  571

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ala Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  572
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV8b1-B

<400>  572

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ala Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  573
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV8b1-C

<400>  573

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ala Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  574
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV8b1-E

<400>  574

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ala Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  575
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV8b562-A

<400>  575

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Lys Gln 
            20                  25                  30          


Ser Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ala Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  576
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV8b562-B

<400>  576

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Lys Gln 
            20                  25                  30          


Ser Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ala Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  577
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV8b562-C

<400>  577

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Lys Gln 
            20                  25                  30          


Ser Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ala Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  578
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV8b562-E

<400>  578

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Lys Gln 
            20                  25                  30          


Ser Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ala Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  579
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV8bu-A

<400>  579

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Lys Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ala Leu Thr Phe Arg Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  580
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV8bu-B

<400>  580

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Lys Gln 
            20                  25                  30          


Ser Arg Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser His Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ala Leu Thr Phe Arg Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  581
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_9 target + gateway seqs

<400>  581
tggcatacaa gtttgcaaga ccacgtaagg caggggggca atcgtctgtc a              51


<210>  582
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_9 target + gateway seqs

<400>  582
tggcatacaa gtttgcaaga ccacgtaagg caggggggca atcgtctgtc a              51


<210>  583
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV9-b56-A

<400>  583

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Glu Leu Ser Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  584
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV9-b56-C

<400>  584

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Glu Leu Ser Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  585
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV9-b56-E

<400>  585

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Glu Leu Ser Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  586
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV9-b56-F

<400>  586

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Glu Leu Ser Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  587
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV9-bu-A

<400>  587

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Arg Lys Phe Lys His Gln Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Glu Leu Ser Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  588
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV9-bu-C

<400>  588

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Arg Lys Phe Lys His Gln Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Glu Leu Ser Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  589
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV9-bu-E

<400>  589

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Arg Lys Phe Lys His Gln Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Glu Leu Ser Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  590
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HSV9-bu-F

<400>  590

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Arg Lys Phe Lys His Gln Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Glu Leu Ser Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  591
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_12 target + gateway seqs

<400>  591
tggcatacaa gtttcctgga catggagacg gggaacatca atcgtctgtc a              51


<210>  592
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.5 / hsv_12.3 cleaving variant 1

<400>  592

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  593
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.5 / hsv_12.3 cleaving variant 2

<400>  593

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Val Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  594
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.5 / hsv_12.3 cleaving variant 3

<400>  594

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Arg Ser Ser Pro Ala Ala Asp 
                165         


<210>  595
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.5 / hsv_12.3 cleaving variant 4

<400>  595

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  596
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.5 / hsv_12.3 cleaving variant 5

<400>  596

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Arg Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  597
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.5 / hsv_12.3 cleaving variant 6

<400>  597

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Arg Ser Ser Pro Ala Ala Asp 
                165         


<210>  598
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.5 / hsv_12.3 cleaving variant 7

<400>  598

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Gly 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  599
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.5 / hsv_12.3 cleaving variant 8

<400>  599

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Gly 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  600
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.6 / hsv_12.4 cleaving variant 1

<400>  600

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Ala Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  601
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.6 / hsv_12.4 cleaving variant 2

<400>  601

Met Ala Asn Thr Lys Tyr Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Glu Ser Ser Pro Ala Ala Asp 
                165         


<210>  602
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.6 / hsv_12.4 cleaving variant 3

<400>  602

Met Ala Asn Thr Lys Tyr Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Arg Pro Leu His Asn Ile Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  603
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.6 / hsv_12.4 cleaving variant 4

<400>  603

Met Ala Asn Thr Lys Tyr Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Ile Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  604
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.6 / hsv_12.4 cleaving variant 5

<400>  604

Met Ala Asn Thr Lys Tyr Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Ile Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Ser Ala Ala Asp 
                165         


<210>  605
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Table xxxxvi HSV_12.6 / hsv_12.4 cleaving variant 6

<400>  605

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Asn Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  606
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  HSV_12 target + cloning seqs

<400>  606
tggcatacaa gtttcctgga catggagacg gggaacatca atcgtctgtc a              51


<210>  607
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HV12-M1-ME

<400>  607

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Ser 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Ile Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Ser 
        


<210>  608
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HV12-M1-80K-ME

<400>  608

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Ser 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Ile Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Ser 
        


<210>  609
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HV12-M1-80K-ME-132V

<400>  609

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Ser 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Ile Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Ser 
        


<210>  610
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HV12-M1-105A-ME

<400>  610

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Ser 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Ile Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Ser 
        


<210>  611
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HV12-M1-105A-ME-80K132V

<400>  611

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Ser 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Ile Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Ser 
        


<210>  612
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  SCOH-HV12-M1-105A-ME-105A132V

<400>  612

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Ser 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


His Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Thr Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Ile Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Ser 
        


<210>  613
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  10ATT_P target

<400>  613
cattacgtcg tacgacgtaa tg					      22


<210>  614
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  5TGG_P target

<400>  614
caaaactggg tacccagttt tg					      22

<210>  615
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  5CTT_P target

<400>  615
caaaaccttg tacaaggttt tg					      22

<210>  616
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV12 target

<400>  616
tattcttggg aacaagagct ac					      22

<210>  617
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV12.2 target

<400>  617
tattcttggg tacaagagct ac					      22

<210>  618
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV12.3 target

<400>  618
tattcttggg tacccaagaa ta					      22

<210>  619
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV12.4 target

<400>  619
gtagctcttg tacaagagct ac					      22

<210>  620
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV12.3 target oligonucleotide

<400>  620
tggcatacaa gtttatattc ttgggtaccc aagaatatca atcgtctgtc a              51

                                
<210>  621
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.3 I-CreI variant

<400>  621

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Arg Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  622
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.3 I-CreI variant

<400>  622

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  623
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.3 I-CreI variant

<400>  623

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Thr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  624
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.3 I-CreI variant

<400>  624

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Tyr Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  625
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.3 I-CreI variant

<400>  625

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  626
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.3 I-CreI variant

<400>  626

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ala Ala Lys Phe Lys His Gly Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  627
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV12.4 target oligonucleotide

<400>  627

tggcatacaa gttttgtagc tcttgtacaa gagctacaca atcgtctgtc a              51

<210>  628
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.4 I-CreI variant

<400>  628

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  629
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.4 I-CreI variant

<400>  629

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Lys Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  630
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.4 I-CreI variant

<400>  630

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  631
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.4 I-CreI variant

<400>  631

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  632
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.4 I-CreI variant

<400>  632

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Ala Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  633
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.4 I-CreI variant

<400>  633

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  634
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12.4 I-CreI variant

<400>  634

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asn Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  635
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  635

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  636
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  636

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Tyr Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  637
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  637

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


His Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  638
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  638

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Arg Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Pro Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  639
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  639

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Arg Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  640
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  640

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Arg Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Arg Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  641
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  641

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Arg Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Gly Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  642
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  642

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Arg Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Glu Ser Ser Pro Ala Ala Asp 
                165         


<210>  643
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  643

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Arg Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165         

<210>  644
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  F54wtR primer

<400>  644
cactagtttg tccagaaacc aacggcgctg ggt                                  33

<210>  645
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  645

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Arg Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  646
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  646

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Arg Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  647
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  647

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gly Tyr Lys Phe Lys His Gly Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  648
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  648

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gly Tyr Lys Phe Lys His Gly Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  649
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  649

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gly Tyr Lys Phe Lys His Gly Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  650
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  650

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Ala Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  651
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  651

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Arg Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Phe Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  652
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  652

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Arg Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Val Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Lys Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  653
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  G19SF primer

<400>  653
gccggctttg tggactctga cggtagcatc atc                                  33

<210>  654
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  G19SR primer

<400>  654
gatgatgcta ccgtcagagt ccacaaagcc ggc                                  33

<210>  655
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  F54LF primer

<400>  655
acccagcgcc gttggctgct ggacaaacta gtg                                  33

<210>  656
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  F54LR primer

<400>  656
cactagtttg tccagcagcc aacggcgctg ggt                                  33

<210>  657
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  E80KF primer

<400>  657
ttaagcaaaa tcaagccgct gcacaacttc ctg                                  33

<210>  658
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  E80KR primer

<400>  658
caggaagttg tgcagcggct tgattttgct taa                                  33

<210>  659
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  F87LF primer

<400>  659
aagccgctgc acaacctgct gactcaactg cag                                  33

<210>  660
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  F87LR primer

<400>  660
ctgcagttga gtcagcaggt tgtgcagcgg ctt                                  33

<210>  661
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  V105AF primer

<400>  661
aaacaggcaa acctggctct gaaaattatc gaa                                  33

<210>  662
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  V105AR primer

<400>  662
ttcgataatt ttcagagcca ggtttgcctg ttt                                  33

<210>  663
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  I132VF primer

<400>  663
acctgggtgg atcaggttgc agctctgaac gat                                  33

<210>  664
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  I132VR primer

<400>  664
atcgttcaga gctgcaacct gatccaccca ggt                                  33

<210>  665
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  665

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Leu Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Gly Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  666
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  666

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  667
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  667

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  668
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  668

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  669
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  669

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  670
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  670

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  671
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  671

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  672
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  V105wtF primer

<400>  672
aaacaggcaa acctggttct gaaaattatc gaa                                  33

<210>  673
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  673

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Ala Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Gly Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  674
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  674

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Arg Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  675
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  675

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  676
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  676

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Leu Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  677
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  I132wtR primer

<400>  677
atcgttcaga gctgcaatct gatccaccca ggt                                  33

<210>  678
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  678

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  679
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  679

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Leu Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Ala Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  680
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  680

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  681
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV12 I-CreI variant

<400>  681

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


His Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Leu Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Lys Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  682
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  10TGA_P target

<400>  682
ctgaacgtcg tacgacgttc ag                                              22

<210>  683
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  10CAA_P target

<400>  683
ccaaacgtcg tacgacgttt gg                                              22

<210>  684
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  5TCT_P target

<400>  684
caaaactctg tacagagttt tg                                              22

<210>  685
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV8 target

<400>  685
ttgaccctta taaagaattt gg                                              22

<210>  686
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV8.2 target

<400>  686
ttgacccttg tacagaattt gg                                              22

<210>  687
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV8.3 target

<400>  687
ttgacccttg tacaagggtc aa                                              22

<210>  688
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV8.4 target

<400>  688
ccaaattctg tacagaattt gg                                              22

<210>  689
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV8.3 target oligonucleotide

<400>  689
tggcatacaa gtttattgac ccttgtacaa gggtcaatca atcgtctgtc a              51


<210>  690
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8.3 I-CreI variant

<400>  690

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ala Lys Phe Lys His Arg Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  691
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8.3 I-CreI variant

<400>  691

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  692
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8.3 I-CreI variant

<400>  692

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His His Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  693
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8.3 I-CreI variant

<400>  693

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ala Lys Phe Lys His Thr Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Tyr Gly Ser Val Ser Ser Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  694
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8.3 I-CreI variant

<400>  694

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Arg Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Asn Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Glu Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  695
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8.3 I-CreI variant

<400>  695

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Phe Pro Ala Ala Asp 
                165         

<210>  696
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV8.4 target oligonucleotide

<400>  696
tggcatacaa gttttccaaa ttctgtacag aatttggaca atcgtctgtc a              51

<210>  697
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8.4 I-CreI variant

<400>  697

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Gln Ala Ala Asp 
                165         

<210>  698
<211>  39
<212>  DNA
<213>  artificial sequence

<220>  
<223>  CreRevBsgI primer

<400>  698
caggtttgcc tgtttctgtt tcagtttcag aaacggctg                            39

<210>  699
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8.4 I-CreI variant

<400>  699

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  700
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8.4 I-CreI variant

<400>  700

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Asn Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  701
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8.4 I-CreI variant

<400>  701

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  702
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8.4 I-CreI variant

<400>  702

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Glu Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  703
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV8 target oligonucleotide

<400>  703
tggcatacaa gtttattgac ccttataaag aatttggaca atcgtctgtc a              51

<210>  704
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8.4 I-CreI variant

<400>  704

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  705
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8 I-CreI variant

<400>  705

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  706
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8 I-CreI variant

<400>  706

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  707
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8 I-CreI variant

<400>  707

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  708
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8 I-CreI variant

<400>  708

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  709
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8 I-CreI variant

<400>  709

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  710
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8 I-CreI variant

<400>  710

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  711
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8 I-CreI variant

<400>  711

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  712
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8 I-CreI variant

<400>  712

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Ile Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  713
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8 I-CreI variant

<400>  713

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  714
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8 I-CreI variant

<400>  714

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  715
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV8 I-CreI variant

<400>  715

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  716
<211>  77
<212>  DNA
<213>  artificial sequence

<220>  
<223>  attB1-ICreIFor

<400>  716
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatgg ccaataccaa     60

atataacaaa gagttcc                                                    77

<210>  717
<211>  64
<212>  DNA
<213>  artificial sequence

<220>  
<223>  attB2-ICreIRev

<400>  717
ggggaccact ttgtacaaga aagctgggtt tagtcggccg ccggggagga tttcttcttc     60

tcgc                                                                  64

<210>  718
<211>  18
<212>  DNA
<213>  artificial sequence

<220>  
<223>  I-SceI target

<400>  718
tagggataac agggtaat                                                   18

<210>  719
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  10TGC_P target

<400>  719
ctgcacgtcg tacgacgtgc ag                                              22

<210>  720
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  10TCT_P target

<400>  720
ctctacgtcg tacgacgtag ag                                              22

<210>  721
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  5TAC_P target

<400>  721
caaaactacg tacgtagttt tg                                              22

<210>  722
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  5TCC_P target

<400>  722
caaaactccg tacggagttt tg                                              22

<210>  723
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV3 target

<400>  723
ctgccttact tttggaagag aa                                              22

<210>  724
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV3.2 target

<400>  724

ctgccttacg tacggaagag aa                                              22

<210>  725
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV3.3 target

<400>  725
ctgccttacg tacgtaaggc ag                                              22

<210>  726
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV3.4 target

<400>  726
ttctcttccg tacggaagag aa                                              22

<210>  727
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV3.5 target

<400>  727
ctgccttact tttgtaaggc ag                                              22

<210>  728
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV3.6 target

<400>  728
ttctcttcct tttggaagag aa                                              22

<210>  729
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV3.3 target oligonucleotide

<400>  729
tggcatacaa gtttcctgcc ttacgtacgt aaggcaggca atcgtctgtc a              51

<210>  730
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.3 I-CreI variant

<400>  730

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Arg Leu His Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  731
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.3 I-CreI variant

<400>  731

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  732
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.3 I-CreI variant

<400>  732

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  733
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.3 I-CreI variant

<400>  733

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Arg Leu Glu Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  734
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.3 I-CreI variant

<400>  734

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Arg Leu Gln Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  735
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV3.4 target oligonucleotide

<400>  735
tggcatacaa gttttttctc ttccgtacga cgtaaagaca atcgtctgtc a              51


<210>  736
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4 I-CreI variant

<400>  736

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  737
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4 I-CreI variant

<400>  737

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Trp Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  738
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4 I-CreI variant

<400>  738

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gln Gln 
            20                  25                  30          


Ser Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  739
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4 I-CreI variant

<400>  739

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ala Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  740
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4 I-CreI variant

<400>  740

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Cys Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  741
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV3.2 target oligonucleotide

<400>  741
tggcatacaa gtttcctgcc ttacgtacgg aagagaaaca atcgtctgtc a              51

<210>  742
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV3 target oligonucleotide

<400>  742
tggcatacaa gtttcctgcc ttacttttgg aagagaaaca atcgtctgtc a              51

<210>  743
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.3 I-CreI variant

<400>  743

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  744
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.3 I-CreI variant

<400>  744

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  745
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4 I-CreI variant

<400>  745

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  746
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4 I-CreI variant

<400>  746

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Met Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  747
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4 I-CreI variant

<400>  747

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Met Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  748
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4 I-CreI variant

<400>  748

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  749
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4 I-CreI variant

<400>  749

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  750
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4 I-CreI variant

<400>  750

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  751
<211>  50
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV3.5 target oligonucleotide

<400>  751
tggcatacaa gtttcctgcc tacttttgta aggcaggcaa tcgtctgtca                50

<210>  752
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.5 I-CreI variant

<400>  752

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Arg Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  753
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.5 I-CreI variant

<400>  753

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  754
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.5 I-CreI variant

<400>  754

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  755
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.5 I-CreI variant

<400>  755

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Asn Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Gly Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  756
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.5 I-CreI variant

<400>  756

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Ser Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  757
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.5 I-CreI variant

<400>  757

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Ala Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  758
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.5 I-CreI variant

<400>  758

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Leu Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  759
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.5 I-CreI variant

<400>  759

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Pro Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  760
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV3.6 target oligonucleotide

<400>  760
tggcatacaa gttttttctc ttccttttgg aagagaaaca atcgtctgtc a              51

<210>  761
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  761

Met Ala Asp Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Met Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  762
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  762

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Met Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  763
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  763

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ile Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  764
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  764

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Met Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  765
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  765

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Met Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Ala Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  766
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  I132wtF primer

<400>  199
acctgggtgg atcagattgc agctctgaac gat                                  33
<210>  767
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  766	

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Met Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  768
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  768

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Met Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Thr Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  769
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  769

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Leu Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  770
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  770

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  771
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  771

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Phe Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Met Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  772
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.5 I-CreI variant

<400>  772

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Gly Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  773
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.5 I-CreI variant

<400>  773

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Arg 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  774
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.5 I-CreI variant

<400>  774

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn His 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  775
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  775

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Met Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Arg Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  776
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  776

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Met Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Val Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Tyr Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  777
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  777

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Met Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  778
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  778

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Arg 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Ala Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  779
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.6 I-CreI variant

<400>  779

Met Ala Ser Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  780
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3 I-CreI variant

<400>  780

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Met Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  781
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3 I-CreI variant

<400>  781

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  782
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3 I-CreI variant

<400>  782

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Met Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  783
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3 I-CreI variant

<400>  783

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Met Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  784
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3 I-CreI variant

<400>  784

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  785
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3 I-CreI variant

<400>  785

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Gly Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Cys Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  786
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3 I-CreI variant

<400>  786

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Val Ile Ala Arg Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  787
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3 I-CreI variant

<400>  787

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Arg Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Ser Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  788
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HBV12-B1

<400>  788

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Arg Leu Thr Phe Arg Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        

<210>  789
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3 I-CreI variant

<400>  789

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Arg Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Gly Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  790
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3 I-CreI variant

<400>  790

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Arg Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Arg Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  791
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3 I-CreI variant

<400>  791

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Arg Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  792
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3 I-CreI variant

<400>  792

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Arg Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Gly Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  793
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.3_R5 I-CreI variant

<400>  793

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Arg Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  794
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4_A7 I-CreI variant

<400>  794

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Met Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  795
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4_R2 I-CreI variant

<400>  795

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Met Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  796
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4_R4 I-CreI variant

<400>  796

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Met Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  797
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4_R5 I-CreI variant

<400>  797

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Met Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  798
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HBV3.4_R6 I-CreI variant

<400>  798

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Met Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         

<210>  799
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  single chain SC_34

<400>  799

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Arg Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser Cys 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Met Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  800
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  single chain SC_OH_34

<400>  800

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Arg Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser Cys 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Met Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        

<210>  801
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  F54wtF primer

<400>  801
acccagcgcc gttggtttct ggacaaacta gtg                                  33

<210>  802
<211>  33
<212>  DNA
<213>  artificial sequence

<220>  
<223>  V105wtR primer

<400>  802
ttcgataatt ttcagaacca ggtttgcctg ttt                                  33

<210>  803
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV12 target oligonucleotide

<400>  803
tggcatacaa gtttatattc ttgggaacaa gagctacaca atcgtctgtc a              51

<210>  804
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HBV12-B2

<400>  804

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gln Tyr Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Arg Leu Thr Phe Arg Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        

<210>  805
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HBV12-B3

<400>  805

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Arg Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asp Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Ser Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln His Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Arg Leu Thr Phe Arg Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 

<210>  806
<211>  24
<212>  DNA
<213>  artificial sequence

<220>  
<223>  Rag target 

<400>  806
ttgttctcag gtacctcagc caga                                            24
        
<210>  807
<211>  31
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV12-For oligonucleotide

<400>  807
ctagctgtag ctcttgttcc caagaatatt g                                    31

<210>  808
<211>  30
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV12-Rev oligonucleotide

<400>  808
ctagcatatt cttgggaaca agagctacag                                      30

<210>  809
<211>  30
<212>  DNA
<213>  artificial sequence

<220>  
<223>  SCEI-For oligonucleotide

<400>  809
ctagcacgct agggataaca gggtaatatg                                      30

<210>  810
<211>  30
<212>  DNA
<213>  artificial sequence

<220>  
<223>  SCEI-Rev oligonucleotide

<400>  810
ctagcatatt accctgttat ccctagcgtg                                      30

<210>  811
<211>  418
<212>  DNA
<213>  artificial sequence

<220>  
<223>  hAAT promoter

<400>  811
ggatcttgct accagtggaa cagccactaa ggattctgca gtgagagcag agggccagct     60
aagtggtact ctcccagaga ctgtctgact cacgccaccc cctccacctt ggacacagga    120
cgctgtggtt tctgagccag gtacaatgac tcctttcggt aagtgcagtg gaagctgtac    180
actgcccagg caaagcgtcc gggcagcgta ggcgggcgac tcagatccca gccagtggac    240
ttagcccctg tttgctcctc cgataactgg ggtgaccttg gttaatattc accagcagcc    300
tcccccgttg cccctctgga tccactgctt aaatacggac gaggacaggg ccctgtctcc    360
tcagcttcag gcaccaccac tgacctggga cagtgaatga tccccctgat ctgcggcc      418

<210>  812
<211>  282
<212>  DNA
<213>  artificial sequence

<220>  
<223>  bpA

<400>  812
cccgggggat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc     60
cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag    120
gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag    180
gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct    240
atggcttctg aggcggaaag aaccagctgg ggctcgagat cc                       282

<210>  813
<211>  328
<212>  DNA
<213>  artificial sequence

<220>  
<223>  ApoE-HCR

<400>  813
caggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt     60
cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc    120
ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct    180
ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac    240
ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg    300
tggtttaggt agtgtgagag ggtccggg                                       328

<210>  814
<211>  1438
<212>  DNA
<213>  artificial sequence

<220>  
<223>  factor IX first intron

<400>  814
gtttgtttcc ttttttaaaa tacattgagt atgcttgcct tttagatata gaaatatctg     60
atgctgtctt cttcactaaa ttttgattac atgatttgac agcaatattg aagagtctaa    120
cagccagcac gcaggttggt aagtactggt tctttgttag ctaggttttc ttcttcttca    180
tttttaaaac taaatagatc gacaatgctt atgatgcatt tatgtttaat aaacactgtt    240
cagttcatga tttggtcatg taattcctgt tagaaaacat tcatctcctt ggtttaaaaa    300
aattaaaagt gggaaaacaa agaaatagca gaatatagtg aaaaaaaata accacattat    360
ttttgtttgg acttaccact ttgaaatcaa aatgggaaac aaaagcacaa acaatggcct    420
tatttacaca aaaagtctga ttttaagata tatgacattt caaggtttca gaagtatgta    480
atgaggtgtg tctctaattt tttaaattat atatcttcaa tttaaagttt tagttaaaac    540
ataaagatta acctttcatt agcaagctgt tagttatcac caaagctttt catggattag    600
gaaaaaatca ttttgtctct atgtcaaaca tcttggagtt gatatttggg gaaacacaat    660
actcagttga gttccctagg ggagaaaagc aagcttaaga attgacataa agagtaggaa    720
gttagctaat gcaacatata tcactttgtt ttttcacaac tacagtgact ttatgtattt    780
cccagaggaa ggcatacagg gaagaaatta tcccatttgg acaaacagca tgttctcaca    840
ggaagcattt atcacactta cttgtcaact ttctagaatc aaatctagta gctgacagta    900
ccaggatcag gggtgccaac cctaagcacc cccagaaagc tgactggccc tgtggttccc    960
actccagaca tgatgtcagc tgtgaaatcg acgtcgctgg accataatta ggcttctgtt   1020
cttcaggaga catttgttca aagtcatttg ggcaaccata ttctgaaaac agcccagcca   1080
gggtgatgga tcactttgca aagatcctca atgagctatt ttcaagtgat gacaaagtgt   1140
gaagttaacc gctcatttga gaactttctt tttcatccaa agtaaattca aatatgatta   1200
gaaatctgac cttttattac tggaattctc ttgactaaaa gtaaaattga attttaattc   1260
ctaaatctcc atgtgtatac agtactgtgg gaacatcaca gattttggct ccatgcccta   1320
aagagaaatt ggctttcaga ttatttggat taaaaacaaa gactttctta agagatgtaa   1380
aattttcatg atgttttctt ttttgctaaa actaaagaat tattctttta catttcag     1438












            

