                         SEQUENCE LISTING

<110>  Helmholtz-Zentrum fuer Infektionsforschung GmbH
       Wei, Dr., Siegfried
       Bartels, Dr., Sara
       Lner, Dr., Holger
       Deyneko, Igor
       Westphal-Daniel, Dr., Kathrin
 
<120>  Tumour-specific bacterial promotor elements

<130>  G1023PCT

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 1 (tumour specific promoter element motif), 
       wherein r = g or a, y = t or c, m = a or c, k = g or t, w = a or 
       t, s = g or c, 

       b = t or g or c, v = a or g or c, h = a or t or c, d = a or t or 
       


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<400>  1
yhnydtkttw ttwanasrwa m                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 2 (tumour specific promoter element motif)"

<400>  2
cagtatttta tttaaaggta a                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 3 (tumour specific promoter element motif), 
       wherein r = a or g"

<400>  3
ccatatttta tttaraggta a                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 4 (tumour specific promoter element motif)"

<400>  4
ccatatttta tttagaggta a                                                 21


<210>  5
<211>  472
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 5 (4ydiH)"

<400>  5
gatctttgat gaacagggac gtctgtgctg ttcttcgcgt cttactacag cgattgtgtg       60

acgttgtcac cataaaagtg tgatgcatat tgcttttggt caaaatgtgc gcagaaaaag      120

gtgatatact gtgcacgttt acacataagc gaggatgata tgtctactga tttggaccca      180

acccaactgg cgattgaatt tttacgccgt gataaaaccg aactttctcc cgcgcagtat      240

ttgaagcgtt taaaacagct ggagttagag tttgccgatc tcctcaccct ctcagcaacc      300

gaactgaaag aagagatcta tttcgcctgg cggttgggcg tgcattaata aagtctgtgt      360

aggccggata aggcgttagc cgccatccgg ctatgttacc aggcaatctc accagacctt      420

gtccccaggt aatagataac ccccttgatt ttgtttaaaa aaaatacaga tc              472


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 6 (tumor-specific promotor element of 4ydiH)"

<400>  6
ttttgtttaa aaaaaataca g                                                 21


<210>  7
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 7 (t48gIpT)"

<400>  7
gatcgatggc ttcagcgcca atgcctgccg cttcacaggc gcgaataaag gtggcctgaa       60

acgcaagatc atcttccggc aacgtaataa acagaccatc cgtcggttcg acgcaatggc      120

gggcgatccg ttttaaaatc tggttttcac taatgcactc gcgcgcggat tccgcgtcgg      180

taaccgcata acgagcgccg ctgtgcagca gcccgtggtt acgcccggtc gcgccggtcg      240

ctatatcatg ccgctccacc agaatgacac gtaaaccgcg cagcgcgcag tcgcgggcga      300

tccctgcgcc tgttgctcca ccgccaatga taatcacgtc acttgtttgc gagtcgcgag      360

ttttcattgt ttttcctcac agttcgtttt ttatcattta gccatacaaa tcatatgtaa      420

tgtttgattt cgcgcataat cgctcactat tcgaaaatga aacgtgattt cgtgcgcctt      480

tctgaacatt agtcataaat ctgtaacaat atgtgctgta attcacatta acgtgacgta      540

tctttactta acatcgcggc cacactggga gcagcggggt tgtttgaacg aactgcggtg      600

tttacctcta aataaaatat gggccacgga ggctacaata tgttgagtat ttttaaacca      660

gcgccgcata aagcgcgctt gccagcggcg gagattgatc cgacctatcg ccgattacgc      720

tggcagattt tcctggggat attctttggc tatgccgcgt attatctggt gcgcaagaac      780

tttgccctcg cgatgcccta cctggtagaa cagggttttt cacgcggcga tctgggcttt      840

gcgctgtccg ggatttccat cgcttatggt ttttcgaaat ttataatggg ttcggtgtcc      900

gatcgctcga atccgcgcgt ttttctgccg gcagggttga ttctggccgc agcagtcatg      960

ttgtttatgg gctttgtgcc gtgggcgaca tccagcatcg ccgtgatgtt tgtactgttg     1020

ttcctttgcg gctggttcca ggggatgggg tggccgccgt gcggtcgtac gatggttcac     1080

tggtggtcgc agaaagagcg cggcggcatt gtgtcggtct ggaacggcgc gcataacgtc     1140

ggcggcggga tc                                                         1152


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 8 (tumor-specific promotor element of 48GIpT)"

<400>  8
ttacctctaa ataaaatatg g                                                 21


<210>  9
<211>  1093
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 9 (92yhjU)"

<400>  9
gatcgcttta caggcgaacc cccttctcaa tcgtcatcgg atgatttacg gtacgttaac       60

ggcggaactt tccacaaccg tacatgcgct ggcactgcat acttataccc tcaaagagtg      120

ggaaggattg caggatacta tcttcgcgtc gcctccttgt cgcggcgcgg gaagcatcgc      180

gtagcaaaac ggatttgcaa ctacctccgc ttttccagta tgttgctaca gaattatgtg      240

aaaacggcct gcgggccgtt ttgttttgtc tgaattttga gcgtgtcgta cagtattcag      300

acaaaaatta gccgagaatt gtgaaaaccg ccgcagcatc gcacaatcac cgttctcgac      360

tcacaaaagt gatgccgcta taatgcgccg tcttatatat gaacgtcttc gggatgattc      420

tgacgacagg gaatgtgatt gattacgaga acatcccggt tccgcgaagc aaatagcacg      480

tgcttgcgga gtagagttga ccgagcactg tgattttttg aggtaacaag atgcaagttt      540

cagttgaaac cactcagggg ccttggccgc cgtgtaacga ttacaatcgc tgctgacagc      600

atcgagaccg ctgtaaaaag cgagctggtc aacgtagcga aaaaagtacg tattgacggc      660

ttccgtaaag gcaaagtacc gatgaatatc gtcgctcagc gttatggcgc ttctgttcgc      720

caggacgtgc tgggcgatca ttccctggaa cgccccgctt tcacgctgcc tgacgcttat      780

tgaaagcgtg caggggcagc agttcagccg ttacgtaccg gaagacatca ccacgctact      840

gtcgatgacg cagccgttga aactgcgcgg ttttcagccg tgggatacct tctgcgatgc      900

catccatacg atgatgagca acaccctgct ccccgccgac gggaaaggcg ttctggtcgc      960

gctgcgcccg gtgccgggca ttcgggttga gcaggcgtta acattatgtc ggccaaacag     1020

ggccggcgat attatgacca tcggcggcaa ccgtctggaa aggtggttat cattctgccg     1080

gggtctaacg atc                                                        1093


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 10 (tumor-specific promotor element of 92yhjU)"

<400>  10
cactgtgatt ttttgaggta a                                                 21


<210>  11
<211>  715
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 11 (135dniR)"

<400>  11
gatcccggcg aagcggcccc cgtcttaaag gccattgctg aacataagtg gatgccggag       60

gcgatttttt tgacgcatca ccatcacgac catgttggcg gagtcaaaga gctgttgcaa      120

cacttcccgc aaatgacggt ttatggaccg gcggaaacgc aagacaaggg agcaacccat      180

cttgttggcg atggcgatac tattcgcgtt ttaggcgaga aatttactct ttttgccacg      240

ccgggccaca cgttaggaca cgtctgttac tttagccgcc cttacttatt ctgcggcgac      300

acgctgtttt ccggcggctg tggtcgactg tttgaaggca cgccatcaca gatgtatcag      360

tcacttatga aaattaactc tctgcctgac gacacgctca tttgctgcgc tcacgaatac      420

actttagcta acattaagtt cgcattgagc atacttccgc acgattcgtt cataaatgaa      480

tattatcgta aagttaaaga gttacgtgta aaaaaacaaa tgacattacc cgttattctt      540

aaaaatgagc gtaagattaa tcttttttta agaactgaag atattgattt aattaacgaa      600

ataaacaaag aaacaatatt gcaacaacca gaagcgcgtt ttgcatggtt aaggtcaaag      660

aaagacacgt tctgataatt cttacttgtc attcgctaac ttcgccgtta tgatc           715


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 12 (tumor-specific promotor element of 
       134dniR)"

<400>  12
ttacgtgtaa aaaaacaaat g                                                 21


<210>  13
<211>  466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 13 (154mdh)"

<400>  13
gatccggatt acgcaaatta aatgcataaa agccaaaatt gcgcgactcc gcattcttga       60

tgagtgagga ttgtaatcat tgaatttgtg aattaaggtc gccgccgcgg agcaatagac      120

acttagctaa tcatataata aggagtttag gatgaaagtc gcagtcctcg gcgctgctgg      180

tggtatcggt caggcgctgg cattactttt aaaaaaccaa ctgccttcag gttcagaact      240

ctccctgtac gacatcgctc cagtgactcc cggtgtggcc gttgatttga gccacatccc      300

caccgctgta aaaatcaaag gtttctccgg tgaagacgca accccggcgc ttgaaggcgc      360

tgacgtagta ctgatttctg cgggtgtggc gcgtaagccg ggtatggacc gttccgacct      420

gtttaacgtt aacgccggca tcgtgaaaaa cctggtgcag cagatc                     466


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 14 (tumor-specific promotor element of 154mdh)"

<400>  14
ttacttttaa aaaaccaact g                                                 21


<210>  15
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 15 (156yeel)"

<400>  15
gatcgcaagg tgaaaatgag cccaaccctg gacaggaagc gttgagcttt tcgatgtgcg       60

ccagttaaaa ttctggcgtt tttttctcac cgaattttct cattttttct caacgtgatt      120

ttcatcacta taagaaaatc acgtaagtgc ttgaatagtg gcggagagag agggattcga      180

accctcggcg gagttacccc cgcaacggtt ttcgagaccg gtccgttcag ccgctccggc      240

atctctccgt atattgcaat gatgccaggt aatttggcat tttaacagac cctattcggg      300

taattttgtt caagtgacga gtttacgagc aaaacgatga ttaagtggcc ctggaaagca      360

caagaaataa cccagaacga agactggccg tgggatgatg cgctggctat acctcttctg      420

gtaaacctca ccgcgcaaga acaggctcgg cttattgcgc tagccgaacg ttttttgcag      480

cagaaaagac tggtagcgct acagggattt gagctcgact cgttaaaaag tgcacgtatt      540

gcgttaattt tttgcttacc gatc                                             564


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 16 (tumor-specific promotor element of 
       156yeel)"

<400>  16
tctcattttt tctcaacgtg a                                                 21


<210>  17
<211>  441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 17 (172frdA)"

<400>  17
gatcggcaaa gaaacgacgg atttccgcca taatcgccgc acgttttaat aaattgggga       60

tggacgcgct cggctgccag gttgccgttt cgctcatgat tctttctcca gtttaagaca      120

aggtcacgaa gtctactcgc aacgcgcggg cgaaacaaat tttgcgcagg cgtatcgggc      180

gccttctgga gggtaaaaaa agtgatttca gatggtttag taattaaatt aatcaaaatc      240

aatgataatt catccctctg atacgctaaa aaaatcgaac acgtcaaatt tccctcacat      300

ccctgagact atactgttgt acccataaag gagcagtgga aacgcattca tacttcgcag      360

aacccagagg ctttatctgg ctgcgcgagg gtgaaattac aataatctgg aggaatgtcg      420

tgcaaacctt tcaagccgat c                                                441


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 18 (tumor-specific promotor element of 
       172frdA)"

<400>  18
gcacgtttta ataaattggg g                                                 21


<210>  19
<211>  614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 19 (185pfkA)"

<400>  19
gatcgcgcgc tgcccgatgc ggaacgacag gaaattattg atatcgtgac gtcatggccg       60

ggagtcagcg gcgcgcacga tctccgcacg cggcagtcag ggccgactcg ctttattcag      120

attcatttgg aaatggaaga taatctgccg ctcgttcagg cgcattttgt ggctgaccag      180

attcatttgg aaatggaaga taatctgccg ctcgttcagg cgcattttgt ggctgaccag      240

tgttcagtcg ttcccaggga aggcaggaag ttcgagcttg tataattgat tgttaaaaag      300

tgagccaggc cagcattttg tgtataaatt accgccattt ggcctgacct gaatcaattc      360

agcaggaagg gattgttata ctatctgtat attcgttgga tcgtttcgaa gtgcgaaatc      420

ggcttccggc aatagatttc attttgcatt ccaaagttca gaggtagtca tgattaagaa      480

aatcggtgtg ttgacaagcg gcggtgatgc gccgggcatg aacgcggcaa tccgcggtgt      540

tgtgcgcgca gcgttgacgg aagggctgga agtcatgggc atttatgacg gctatctggg      600

cctgtatgaa gatc                                                        614


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 20 (tumor-specific promotor element of 
       185pfkA)"

<400>  20
cagcattttg tgtataaatt a                                                 21


<210>  21
<211>  437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 21 (212pflE)"

<400>  21
gatcggttcg ctacaggcaa tggaggccat taagctactg gcgcattacg gtcagcctgc       60

cagcggaaaa atcgtcatgt acgatgcgat gacctgtcag ttccgcgaaa tgaagttaat      120

gcgcaacccc ggctgtgagg tctgcgggca gtagccactt tacggataaa cataccaaag      180

cacggtttat ggccgtgctg tatcaacaga taattactgt catcagacgc aaagccagct      240

tacccaagct ccgactgacg atcggctcaa gcagcgcggc atcatcttaa acgccatacc      300

acaacctcaa accgtgatgt tgtacctcat ttaacgcctc tttgtcagaa cctctccatt      360

cgttgacgca catcaagata gctttcattc gaaagtaatt taatctttat atgaaataag      420

agaggccgtt tatgatc                                                     437


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 22 (tumor-specific promotor element of 
       212pflE)"

<400>  22
taatctttat atgaaataag                                                   20


<210>  23
<211>  556
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 23 (nirB)"

<400>  23
gatcgcagca aacgaaagtg gcctcgccta agctggttaa cttcattctg acctgcggca       60

ccatcggaac aatgctgacc ttcgtcgtca ccggcccgat tgtagcgcac agcggcccac      120

aggcggcgtt actcaccgcg aatggtctgt atgcggtggt ctttgtgatg tgctttgcgc      180

tcggctttgt atcccgtcat cgtcagcata gcgcgccggc tacgcattga taatccttgc      240

cggatggaga catcgccctc cggcactcta tcccccctcc tgacggggta ggcctgttgg      300

tctaaaaacc cctcattttg tatgttattt gtacaaacct gaaaagcctg acaattccgc      360

cacttataaa aatccagaca aatcagccat atacccatta agaggtatat aaaggtgaat      420

ttgatttaca tcaataagcg gggttgctga atcgttaagg taggcggtaa tagaaaagaa      480

atcgaggcaa aaatgagcaa agtcagactc gctattatcg gtaatggtat ggtcggccac      540

cgctttattg aggatc                                                      556


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 24 (tumor-specific promotor element of 
       271nirB)"

<400>  24
ttgtatgtta tttgtacaaa c                                                 21


<210>  25
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 25 (301glpA)"

<400>  25
gatcgccgcg tgaaaaaccc tgttctacca ggtagggcat cgcgagggca aagttcttgc       60

gcaccagata atacgcggca tagccaaaga atatccccag gaaaatctgc cagcgtaatc      120

ggcgataggt cggatcaatc tccgccgctg gcaagcgcgc tttatgcggc gctggtttaa      180

aaatactcaa catattgtag cctccgtggc ccatatttta tttagaggta aacaccgcag      240

ttcgttcaaa caaccccgct gctcccagtg tggccgcgat gttaagtaaa gatacgtcac      300

gttaatgtga attacagcac atattgttac agatttatga ctaatgttca gaaaggcgca      360

cgaaatcacg tttcattttc gaatagtgag cgattatgcg cgaaatcaaa cattacatat      420

gatttgtatg gctaaatgat aaaaaacgaa ctgtgaggaa aaacaatgaa aactcgcgac      480

tcgcaaacaa gtgacgtgat tatcattggc ggtggagcaa caggcgcagg gatcgcccgc      540

gactgcgcgc tgcgcggttt acgtgtcatt ctggtggagc ggcatgatat agcgaccggc      600

gcgaccgggc gtaaccacgg gctgctgcac agcggcgctc gttatgcggt taccgacgcg      660

gaatccgcgc gcgagtgcat tagtgaaaac cagattttaa aacggatc                   708


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 26 (tumor-specific promotor element of 
       301glpA)"

<400>  26
ccatatttta tttagaggta a                                                 21


<210>  27
<211>  581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 27 (310ybaL)"

<400>  27
gatcgtatct ttttataaaa cacaaccatt ttttataaac atcctgattg aaattgtcat       60

aaactattac ccggagtttt ggagtccagc aaccaaagga gacggaatgc atcacgctac      120

cccgcttatc accaccattg tcggcggcct tgtgctcgct tttattctcg gcatgattgc      180

caacaaattg cgtatttctc cactggtggg atatctgtta gcgggcgttc tggcgggacc      240

ttttaccccg ggttttgttg cggataccaa actggcgccg gagctggcgg agctcggcgt      300

gattctattg atgttcggcg tcgggctgca tttttcgctg aaggatttga tggcggtaaa      360

gtctatcgcc attcccggcg ctgtcgctca gatagcggtg gcgacgctgc tgggtatggc      420

gctttccgcc gtgctgggat ggtcattaat gaccggcatc gtttttgggc tctgtctgtc      480

tacagccagt accgtcgtcc tgctgcgcgc gcttgaggag cgacaactcc ttgatagcca      540

gcgcgggcaa atcgccatcg gctggctgat tgtcgaagat c                          581


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="SEQ ID NO. 28 (tumor-specific promotor element of 
       310ybaL)"

<400>  28
gtatcttttt ataaaacaca a                                                 21


