
                                SEQUENCE LISTING

<110> GLAXO GROUP LIMITED
      Thil Dinuk BATUWANGALA
      Laurent S JESPERS
      Michael STEWARD

<120> ANTIGEN-BINDING PROTEINS
  

<130> PB63686 WO

<150> 61/181897           
<151> 2009-05-28  

<160> 44

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1734
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fusion proteins

<400> 1
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc 60
gaggtgcagc tgttggtgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 120
tcctgtgcag cctccggatt cacctttaag gcttatccga tgatgtgggt ccgccaggct 180
ccagggaagg gtctagagtg ggtttcagag atttcgcctt cgggttctta tacatactac 240
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 300
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatcct 360
cggaagttag actactgggg tcagggaacc ctggtcaccg tctcgagcgc tagcaccaag 420
ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc 480
ctgggctgcc tggtgaagga ctacttcccc gagcctgtga ccgtgtcctg gaatagcgga 540
gccctgacct ccggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtactcc 600
ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgcaac 660
gtgaaccaca agcccagcaa caccaaagtg gacaagaaag tggagcccaa gagctgcgat 720
aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggcggacc tagcgtgttc 780
ctgttccccc ccaagcctaa ggacaccctg atgatcagca ggacccccga agtgacctgc 840
gtggtggtgg atgtgagcca cgaggaccct gaagtgaagt tcaactggta cgtggacggc 900
gtggaagtgc acaacgccaa gaccaagccc agagaggagc agtacaacag cacctaccgc 960
gtggtgtctg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgc 1020
aaagtgagca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc 1080
cagcctagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1140
caggtgtccc tgacctgtct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg 1200
gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat 1260
ggcagcttct tcctgtactc caagctgacc gtggacaaga gcagatggca gcagggcaac 1320
gtgttcagct gcagcgtgat gcacgaggcc ctgcacaatc actacaccca gaagagtctg 1380
agcctgtccc ctggcaagtc gaccggtgac atccagatga cccagtctcc atcaagcctg 1440
agcgccagcg tgggcgacag agtgaccatc acctgccggg ccagccagtg gatcggcaac 1500
ctgctggact ggtatcagca gaagcccggc aaggccccca agctgctgat ctactacgcc 1560
agcttcctgc agagcggcgt gcccagccgg tttagcggca gcggctacgg caccgacttc 1620
accctgacca tcagcagcct gcagcccgag gacttcgcca cctactactg ccagcaggcc 1680
aaccctgccc ccctgacctt cggccagggg accaaggtgg aaatcaaacg gtaa       1734

<210> 2
<211> 551
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fusion proteins

<400> 2
Glu Val Gln Leu Leu Val Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Ala Tyr
            20                  25                  30          
Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Glu Ile Ser Pro Ser Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Asp Pro Arg Lys Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala
        115                 120                 125             
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
    130                 135                 140                 
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                165                 170                 175     
Gly Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
            180                 185                 190         
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val
        195                 200                 205             
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro
    210                 215                 220                 
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
                245                 250                 255     
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
        275                 280                 285             
Arg Glu Glu Gln Tyr Asn Ser Tyr Val Val Ser Val Leu Thr Val Leu
    290                 295                 300                 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
305                 310                 315                 320 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
                325                 330                 335     
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
            340                 345                 350         
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
        355                 360                 365             
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
    370                 375                 380                 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
385                 390                 395                 400 
Lys Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
            420                 425                 430         
Ser Leu Ser Leu Ser Pro Gly Lys Ser Thr Gly Asp Ile Gln Met Thr
        435                 440                 445             
Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
    450                 455                 460                 
Thr Cys Arg Ala Ser Gln Trp Ile Gly Asn Leu Leu Asp Trp Tyr Gln
465                 470                 475                 480 
Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe
                485                 490                 495     
Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Tyr Gly Thr
            500                 505                 510         
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
        515                 520                 525             
Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly
    530                 535                 540                 
Thr Lys Val Glu Ile Lys Arg
545                 550     


<210> 3
<211> 645
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fusion proteins

<400> 3
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ggatatttac ctgaatttag actggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatcaatttt ggttccgagt tgcaaagtgg tgtcccatca 180
cgtttcagtg gcagtggata tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagatttcg ctacgtacta ctgtcaaccg tctttttact tcccttatac gttcggccaa 300
gggaccaagg tggaaatcaa acggacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctcaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaagtgca gtggaaagtg gacaacgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaaa gtgtacgcct gcgaagtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gctga                 645

<210> 4
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fusion proteins

<400> 4
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Tyr Leu Asn
            20                  25                  30          
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Asn Phe Gly Ser Glu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Pro Ser Phe Tyr Phe Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 5
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 5
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Ser Leu Ser
    50                  55                  60                  
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
65                  70                  75                  80  
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
                85                  90                  95      
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
            100                 105                 110         
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
        115                 120                 125             
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
    130                 135                 140                 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
145                 150                 155                 160 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                165                 170                 175     
Tyr Asn Ser Tyr Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
            180                 185                 190         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
        195                 200                 205             
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
    210                 215                 220                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
225                 230                 235                 240 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                245                 250                 255     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            260                 265                 270         
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Lys Lys Leu Thr
        275                 280                 285             
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
    290                 295                 300                 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
305                 310                 315                 320 
Ser Pro Gly Lys
                


<210> 6
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 6
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105     


<210> 7
<211> 116
<212> PRT
<213> Homo Sapiens

<400> 7
Glu Val Gln Leu Leu Val Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Ala Tyr
            20                  25                  30          
Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Glu Ile Ser Pro Ser Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Asp Pro Arg Lys Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 8
<211> 108
<212> PRT
<213> Homo Sapiens

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asn Leu
            20                  25                  30          
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 9
<211> 108
<212> PRT
<213> Homo Sapiens

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Tyr Leu Asn
            20                  25                  30          
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Asn Phe Gly Ser Glu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Pro Ser Phe Tyr Phe Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 10
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 10
Gly Ser
 1      


<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 11
Thr Val Ala Ala Pro Ser Gly Ser
 1               5              


<210> 12
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 12
Pro Ala Ser
 1          


<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 13
Gly Gly Gly Gly Ser
 1               5  


<210> 14
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 14
Pro Ala Val Pro Pro Pro
 1               5      


<210> 15
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 15
Thr Val Ser Asp Val Pro
 1               5      


<210> 16
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 16
Thr Gly Leu Asp Ser Pro
 1               5      


<210> 17
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 17
Thr Val Ala Ala Pro Ser
 1               5      


<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 18
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser
 1               5                  10  


<210> 19
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 19
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser
        


<210> 20
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 20
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser
            20                  25      


<210> 21
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 21
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
            20                  25                  30          
Gly Ser
        


<210> 22
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 22
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
            20                  25                  30          
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser
        35                  40          


<210> 23
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 23
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
            20                  25                  30          
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
        35                  40                  45              
Gly Ser
    50  


<210> 24
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 24
Pro Ala Ser Gly Ser
 1               5  


<210> 25
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 25
Pro Asp Ala Ser Gly Ser
 1               5      


<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 26
Pro Asp Asp Ala Ser Gly Ser
 1               5          


<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 27
Gly Gly Gly Gly Ser
 1               5  


<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 28
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10  


<210> 29
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 29
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 30
Pro Ala Val Pro Pro Pro Gly Ser
 1               5              


<210> 31
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 31
Pro Ala Val Pro Pro Pro Pro Ala Val Pro Pro Pro Gly Ser
 1               5                  10                  


<210> 32
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 32
Pro Ala Val Pro Pro Pro Pro Ala Val Pro Pro Pro Pro Ala Val Pro
 1               5                  10                  15      
Pro Pro Gly Ser
            20  


<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 33
Thr Val Ser Asp Val Pro Gly Ser
 1               5              


<210> 34
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 34
Thr Val Ser Asp Val Pro Thr Val Ser Asp Val Pro Gly Ser
 1               5                  10                  


<210> 35
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 35
Thr Val Ser Asp Val Pro Thr Val Ser Asp Val Pro Thr Val Ser Asp
 1               5                  10                  15      
Val Pro Gly Ser
            20  


<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 36
Thr Gly Leu Asp Ser Pro Gly Ser
 1               5              


<210> 37
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 37
Thr Gly Leu Asp Ser Pro Thr Gly Leu Asp Ser Pro Gly Ser
 1               5                  10                  


<210> 38
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 38
Thr Gly Leu Asp Ser Pro Thr Gly Leu Asp Ser Pro Thr Gly Leu Asp
 1               5                  10                  15      
Ser Pro Gly Ser
            20  


<210> 39
<211> 86
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated scaffold

<400> 39
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Arg His
 1               5                  10                  15      
Pro His Phe Pro Thr Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly
            20                  25                  30          
Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Leu Gln Pro Pro Thr
        35                  40                  45              
Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val
    50                  55                  60                  
Tyr Ala Val Thr Asp Gly Arg Asn Gly Arg Leu Leu Ser Ile Pro Ile
65                  70                  75                  80  
Ser Ile Asn Tyr Arg Thr
                85      


<210> 40
<211> 94
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated scaffold

<400> 40
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
 1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Asp Thr His Asn Ala Tyr Asn Gly Tyr Tyr
            20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Arg Glu Phe
        35                  40                  45              
Thr Val Pro His Pro Glu Val Thr Ala Thr Ile Ser Gly Leu Lys Pro
    50                  55                  60                  
Gly Val Asp Asp Thr Ile Thr Val Tyr Ala Val Thr Asn His His Met
65                  70                  75                  80  
Pro Leu Arg Ile Phe Gly Pro Ile Ser Ile Asn His Arg Thr
                85                  90                  


<210> 41
<211> 150
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated scaffold

<400> 41
Asp Gly Gly Gly Ile Arg Arg Ser Met Ser Gly Thr Trp Tyr Leu Lys
 1               5                  10                  15      
Ala Met Thr Val Asp Arg Glu Phe Pro Glu Met Asn Leu Glu Ser Val
            20                  25                  30          
Thr Pro Met Thr Leu Thr Leu Leu Lys Gly His Asn Leu Glu Ala Lys
        35                  40                  45              
Val Thr Met Leu Ile Ser Gly Arg Cys Gln Glu Val Lys Ala Val Leu
    50                  55                  60                  
Gly Arg Thr Lys Glu Arg Lys Lys Tyr Thr Ala Asp Gly Gly Lys His
65                  70                  75                  80  
Val Ala Tyr Ile Ile Pro Ser Ala Val Arg Asp His Val Ile Phe Tyr
                85                  90                  95      
Ser Glu Gly Gln Leu His Gly Lys Pro Val Arg Gly Val Lys Leu Val
            100                 105                 110         
Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys
        115                 120                 125             
Ala Ala Gly Arg Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln Ser
    130                 135                 140                 
Glu Thr Cys Ser Pro Gly
145                 150 


<210> 42
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 42
Thr Val Ala Ala Pro Ser Thr Val Ala Ala Pro Ser Gly Ser
 1               5                  10                  


<210> 43
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 43
Thr Val Ala Ala Pro Ser Thr Val Ala Ala Pro Ser Thr Val Ala Ala
 1               5                  10                  15      
Pro Ser Gly Ser
            20  


<210> 44
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 44
Gly Ser Thr Val Ala Ala Pro Ser
 1               5              

