
                                SEQUENCE LISTING

<110> GLAXO GROUP LIMITED
      ASHMAN, Claire
      ELLIS, Jonathan Henry
      HAMBLIN, Paul
      LEWIS, Alan
      ORECCHIA, Martin Anibal

<120> Immunoglobulins
  

<130> PB63682

<150> 61/181833           
<151> 2009-05-28  

<150> 61/288930           
<151> 2009-12-22  

<160> 147

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 5
<212> PRT
<213> Mus sp.

<220> 

<400> 1
Asp Thr Tyr Met His
 1               5  


<210> 2
<211> 17
<212> PRT
<213> Mus sp.

<400> 2
Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe Gln
 1               5                  10                  15      
Gly
    


<210> 3
<211> 16
<212> PRT
<213> Mus sp.

<400> 3
Ser Ile Tyr Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 4
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 4
Trp Ile Tyr Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 5
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 5
Ser Val Tyr Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 6
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 6
Ser Ile Phe Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 7
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 7
Ser Ile Tyr Glu Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 8
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 8
Ser Ile Tyr Asp Asp Tyr Ala Tyr Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 9
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 9
Ser Ile Tyr Asp Asp Tyr Glu Tyr Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 10
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 10
Ser Ile Tyr Asp Asp Tyr Gln Tyr Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 11
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 11
Ser Ile Tyr Asp Asp Tyr Arg Tyr Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 12
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 12
Ser Ile Tyr Asp Asp Tyr Ser Tyr Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 13
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 13
Ser Ile Tyr Asp Asp Tyr Thr Tyr Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 14
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 14
Ser Ile Tyr Asp Asp Tyr Val Tyr Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 15
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 15
Ser Ile Tyr Asp Asp Tyr His Ala Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 16
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 16
Ser Ile Tyr Asp Asp Tyr His Ile Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 17
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 17
Ser Ile Tyr Asp Asp Tyr His Trp Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 18
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 18
Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15      


<210> 19
<211> 16
<212> PRT
<213> Mus sp.

<400> 19
Arg Ser Ser Gln Asn Ile Val His Ile Asn Gly Asn Thr Tyr Leu Glu
 1               5                  10                  15      


<210> 20
<211> 7
<212> PRT
<213> Mus sp.

<400> 20
Lys Ile Ser Asp Arg Phe Ser
 1               5          


<210> 21
<211> 9
<212> PRT
<213> Mus sp.

<400> 21
Phe Gln Gly Ser His Val Pro Trp Thr
 1               5                  


<210> 22
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 22
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 23
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 23
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accactacga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 24
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 24
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
 1               5                  10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ile
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asp Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Asp Asp Val Gly Ile Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 


<210> 25
<211> 657
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 25
gacatcgtga tgacccagtc tcctctgagc ctccccgtga cccccggcga accagccagc 60
atctcctgca gaagcagcca gaacatcgtg cacatcaacg gcaacaccta cctggagtgg 120
tacctgcaaa agcccggcca gagccccagg ctgctgatct acaagatcag cgacaggttc 180
agcggcgtgc ccgataggtt cagcggcagc ggcagcggca ccgacttcac cctgaagatc 240
agcagggtgg aggccgacga cgtgggcatc tactactgct tccagggcag ccacgtcccc 300
tggactttcg gacagggcac caagctggag attaagcgta cggtggccgc ccccagcgtg 360
ttcatcttcc cccccagcga tgagcagctg aagagcggca ccgccagcgt ggtgtgtctg 420
ctgaacaact tctacccccg ggaggccaag gtgcagtgga aggtggacaa tgccctgcag 480
agcggcaaca gccaggagag cgtgaccgag caggacagca aggactccac ctacagcctg 540
agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag 600
gtgacccacc agggcctgtc cagccccgtg accaagagct tcaaccgggg cgagtgc    657

<210> 26
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 26
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Ile Tyr Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 27
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 27
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggtggatc 300
tacgacgact accactacga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 28
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 28
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Val Tyr Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 29
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 29
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcgtc 300
tacgacgact accactacga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 30
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 30
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Phe Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 31
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 31
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tttgacgact accactacga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 32
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 32
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Glu Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 33
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 33
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgaggact accactacga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 34
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 34
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr Ala Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 35
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 35
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact acgcgtacga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 36
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 36
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr Glu Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 37
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 37
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact acgagtacga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 38
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 38
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr Gln Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 39
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 39
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accagtacga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 40
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 40
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr Arg Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 41
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 41
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact acaggtacga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 42
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 42
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr Ser Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 43
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 43
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact actcctacga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 44
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 44
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr Thr Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 45
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 45
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact acacgtacga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 46
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 46
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr Val Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 47
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 47
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact acgtgtacga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 48
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Ala Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 49
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 49
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacgcgga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 50
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 50
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Ile Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 51
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 51
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacattga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 52
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 52
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Trp Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 53
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 53
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accactggga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 54
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 54
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 55
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 55
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacgtcga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaag                 1365

<210> 56
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> signal sequecne

<400> 56
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser
            


<210> 57
<211> 112
<212> PRT
<213> Homo Sapiens

<400> 57
Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu
 1               5                  10                  15      
Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met
            20                  25                  30          
Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu Glu
        35                  40                  45              
Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln Arg
    50                  55                  60                  
Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe Ser
65                  70                  75                  80  
Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe Val Lys
                85                  90                  95      
Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Arg Phe Asn
            100                 105                 110         


<210> 58
<211> 125
<212> PRT
<213> Mus sp.

<400> 58
Glu Ile Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Arg Leu Ser Cys Thr Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Ile Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Arg Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120                 125 


<210> 59
<211> 112
<212> PRT
<213> Mus sp.

<400> 59
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ile
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Ile Ser Asp Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 60
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 60
Phe Tyr Ile Lys Asp Thr Tyr Met His
 1               5                  


<210> 61
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated CDR

<400> 61
Gly Phe Tyr Ile Lys Asp Thr Tyr Met His
 1               5                  10  


<210> 62
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 62
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Ala Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Glu Val Gln
    450                 455                 460                 
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg
465                 470                 475                 480 
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Phe Gly Met Gly
                485                 490                 495     
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Trp Ile
            500                 505                 510         
Ile Ser Ser Gly Thr Glu Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg
        515                 520                 525             
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met
    530                 535                 540                 
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser
545                 550                 555                 560 
Leu Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                565                 570                 575     
Ser
    


<210> 63
<211> 1731
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 63
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacgcgga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ctagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaagaccgt ggccgccccc 1380
tcggaagtgc agctcctgga gagcggcggc ggcctggtgc agcccggcgg cagcctgagg 1440
ctgagctgcg ccgctagcgg cttcaccttc aggaacttcg gcatgggctg ggtcaggcag 1500
gcccccggca agggcctgga gtgggtcagc tggatcatca gctccggcac cgagacctac 1560
tacgccgaca gcgtgaaggg caggttcacc atcagccgcg acaacagcaa gaacaccctg 1620
tacctgcaga tgaacagcct gagggccgag gacaccgccg tctactactg cgccaagagc 1680
ctgggcaggt tcgactactg gggacagggg accctggtga ctgtgagcag c          1731

<210> 64
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 64
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Ile Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Glu Val Gln
    450                 455                 460                 
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg
465                 470                 475                 480 
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Phe Gly Met Gly
                485                 490                 495     
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Trp Ile
            500                 505                 510         
Ile Ser Ser Gly Thr Glu Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg
        515                 520                 525             
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met
    530                 535                 540                 
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser
545                 550                 555                 560 
Leu Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                565                 570                 575     
Ser
    


<210> 65
<211> 1731
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 65
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacattga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ctagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaagaccgt ggccgccccc 1380
tcggaagtgc agctcctgga gagcggcggc ggcctggtgc agcccggcgg cagcctgagg 1440
ctgagctgcg ccgctagcgg cttcaccttc aggaacttcg gcatgggctg ggtcaggcag 1500
gcccccggca agggcctgga gtgggtcagc tggatcatca gctccggcac cgagacctac 1560
tacgccgaca gcgtgaaggg caggttcacc atcagccgcg acaacagcaa gaacaccctg 1620
tacctgcaga tgaacagcct gagggccgag gacaccgccg tctactactg cgccaagagc 1680
ctgggcaggt tcgactactg gggacagggg accctggtga ctgtgagcag c          1731

<210> 66
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 66
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Trp Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Glu Val Gln
    450                 455                 460                 
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg
465                 470                 475                 480 
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Phe Gly Met Gly
                485                 490                 495     
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Trp Ile
            500                 505                 510         
Ile Ser Ser Gly Thr Glu Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg
        515                 520                 525             
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met
    530                 535                 540                 
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser
545                 550                 555                 560 
Leu Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                565                 570                 575     
Ser
    


<210> 67
<211> 1731
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 67
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accactggga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ctagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaagaccgt ggccgccccc 1380
tcggaagtgc agctcctgga gagcggcggc ggcctggtgc agcccggcgg cagcctgagg 1440
ctgagctgcg ccgctagcgg cttcaccttc aggaacttcg gcatgggctg ggtcaggcag 1500
gcccccggca agggcctgga gtgggtcagc tggatcatca gctccggcac cgagacctac 1560
tacgccgaca gcgtgaaggg caggttcacc atcagccgcg acaacagcaa gaacaccctg 1620
tacctgcaga tgaacagcct gagggccgag gacaccgccg tctactactg cgccaagagc 1680
ctgggcaggt tcgactactg gggacagggg accctggtga ctgtgagcag c          1731

<210> 68
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 68
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Glu Val Gln
    450                 455                 460                 
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg
465                 470                 475                 480 
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Phe Gly Met Gly
                485                 490                 495     
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Trp Ile
            500                 505                 510         
Ile Ser Ser Gly Thr Glu Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg
        515                 520                 525             
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met
    530                 535                 540                 
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser
545                 550                 555                 560 
Leu Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                565                 570                 575     
Ser
    


<210> 69
<211> 1731
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 69
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacgtcga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaagaccgt ggccgccccc 1380
tcggaagtgc agctcctgga gagcggcggc ggcctggtgc agcccggcgg cagcctgagg 1440
ctgagctgcg ccgctagcgg cttcaccttc aggaacttcg gcatgggctg ggtcaggcag 1500
gcccccggca agggcctgga gtgggtcagc tggatcatca gctccggcac cgagacctac 1560
tacgccgaca gcgtgaaggg caggttcacc atcagccgcg acaacagcaa gaacaccctg 1620
tacctgcaga tgaacagcct gagggccgag gacaccgccg tctactactg cgccaagagc 1680
ctgggcaggt tcgactactg gggacagggg accctggtga ctgtgagcag c          1731

<210> 70
<211> 578
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 70
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Ala Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Ala Ser Thr Lys Gly Pro Ser Glu Val
    450                 455                 460                 
Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu
465                 470                 475                 480 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Phe Gly Met
                485                 490                 495     
Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Trp
            500                 505                 510         
Ile Ile Ser Ser Gly Thr Glu Thr Tyr Tyr Ala Asp Ser Val Lys Gly
        515                 520                 525             
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
    530                 535                 540                 
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
545                 550                 555                 560 
Ser Leu Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
                565                 570                 575     
Ser Ser
        


<210> 71
<211> 1734
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 71
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacgcgga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg atatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaaggccag caccaagggc 1380
ccctcggaag tgcagctcct ggagagcggc ggcggcctgg tgcagcccgg cggcagcctg 1440
aggctgagct gcgccgctag cggcttcacc ttcaggaact tcggcatggg ctgggtcagg 1500
caggcccccg gcaagggcct ggagtgggtc agctggatca tcagctccgg caccgagacc 1560
tactacgccg acagcgtgaa gggcaggttc accatcagcc gcgacaacag caagaacacc 1620
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtctacta ctgcgccaag 1680
agcctgggca ggttcgacta ctggggacag gggaccctgg tgactgtgag cagc       1734

<210> 72
<211> 578
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 72
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Ile Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Ala Ser Thr Lys Gly Pro Ser Glu Val
    450                 455                 460                 
Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu
465                 470                 475                 480 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Phe Gly Met
                485                 490                 495     
Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Trp
            500                 505                 510         
Ile Ile Ser Ser Gly Thr Glu Thr Tyr Tyr Ala Asp Ser Val Lys Gly
        515                 520                 525             
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
    530                 535                 540                 
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
545                 550                 555                 560 
Ser Leu Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
                565                 570                 575     
Ser Ser
        


<210> 73
<211> 1734
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 73
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacattga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg atatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaaggccag caccaagggc 1380
ccctcggaag tgcagctcct ggagagcggc ggcggcctgg tgcagcccgg cggcagcctg 1440
aggctgagct gcgccgctag cggcttcacc ttcaggaact tcggcatggg ctgggtcagg 1500
caggcccccg gcaagggcct ggagtgggtc agctggatca tcagctccgg caccgagacc 1560
tactacgccg acagcgtgaa gggcaggttc accatcagcc gcgacaacag caagaacacc 1620
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtctacta ctgcgccaag 1680
agcctgggca ggttcgacta ctggggacag gggaccctgg tgactgtgag cagc       1734

<210> 74
<211> 578
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 74
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Trp Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Ala Ser Thr Lys Gly Pro Ser Glu Val
    450                 455                 460                 
Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu
465                 470                 475                 480 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Phe Gly Met
                485                 490                 495     
Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Trp
            500                 505                 510         
Ile Ile Ser Ser Gly Thr Glu Thr Tyr Tyr Ala Asp Ser Val Lys Gly
        515                 520                 525             
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
    530                 535                 540                 
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
545                 550                 555                 560 
Ser Leu Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
                565                 570                 575     
Ser Ser
        


<210> 75
<211> 1734
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 75
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accactggga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg atatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaaggccag caccaagggc 1380
ccctcggaag tgcagctcct ggagagcggc ggcggcctgg tgcagcccgg cggcagcctg 1440
aggctgagct gcgccgctag cggcttcacc ttcaggaact tcggcatggg ctgggtcagg 1500
caggcccccg gcaagggcct ggagtgggtc agctggatca tcagctccgg caccgagacc 1560
tactacgccg acagcgtgaa gggcaggttc accatcagcc gcgacaacag caagaacacc 1620
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtctacta ctgcgccaag 1680
agcctgggca ggttcgacta ctggggacag gggaccctgg tgactgtgag cagc       1734

<210> 76
<211> 578
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 76
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Ala Ser Thr Lys Gly Pro Ser Glu Val
    450                 455                 460                 
Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu
465                 470                 475                 480 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Phe Gly Met
                485                 490                 495     
Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Trp
            500                 505                 510         
Ile Ile Ser Ser Gly Thr Glu Thr Tyr Tyr Ala Asp Ser Val Lys Gly
        515                 520                 525             
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
    530                 535                 540                 
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
545                 550                 555                 560 
Ser Leu Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
                565                 570                 575     
Ser Ser
        


<210> 77
<211> 1734
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised

<400> 77
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacgtcga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg atatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaaggccag caccaagggc 1380
ccctcggaag tgcagctcct ggagagcggc ggcggcctgg tgcagcccgg cggcagcctg 1440
aggctgagct gcgccgctag cggcttcacc ttcaggaact tcggcatggg ctgggtcagg 1500
caggcccccg gcaagggcct ggagtgggtc agctggatca tcagctccgg caccgagacc 1560
tactacgccg acagcgtgaa gggcaggttc accatcagcc gcgacaacag caagaacacc 1620
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtctacta ctgcgccaag 1680
agcctgggca ggttcgacta ctggggacag gggaccctgg tgactgtgag cagc       1734

<210> 78
<211> 108
<212> PRT
<213> Homo Sapiens

<400> 78
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp Trp
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Ala Trp Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Gly Trp Gly Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 79
<211> 108
<212> PRT
<213> Homo Sapiens

<400> 79
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp Trp
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Ala Trp Ala Ser Ser Leu Tyr Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Gly Trp Gly Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 80
<211> 108
<212> PRT
<213> Homo Sapiens

<400> 80
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp Trp
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Gly Trp Gly Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 81
<211> 116
<212> PRT
<213> Homo Sapiens

<400> 81
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Phe
            20                  25                  30          
Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Trp Ile Ile Ser Ser Gly Thr Glu Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Ser Leu Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 82
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 82
Gly Gly Gly Gly Ser
 1               5  


<210> 83
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 83
Thr Val Ala Ala Pro Ser
 1               5      


<210> 84
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 84
Ala Ser Thr Lys Gly Pro Thr
 1               5          


<210> 85
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 85
Ala Ser Thr Lys Gly Pro Ser
 1               5          


<210> 86
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 86
Gly Ser
 1      


<210> 87
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 87
Thr Val Ala Ala Pro Ser Gly Ser
 1               5              


<210> 88
<211> 571
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 88
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp Trp
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Ala Trp Ala Ser Ser Leu Tyr Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Gly Trp Gly Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Ser Thr Val
            100                 105                 110         
Ala Ala Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
        115                 120                 125             
Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr
    130                 135                 140                 
Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
145                 150                 155                 160 
Leu Glu Trp Met Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr
                165                 170                 175     
Val Pro Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr
            180                 185                 190         
Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
        195                 200                 205             
Val Tyr Tyr Cys Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp
    210                 215                 220                 
Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
225                 230                 235                 240 
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
                245                 250                 255     
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
            260                 265                 270         
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
        275                 280                 285             
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
    290                 295                 300                 
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
305                 310                 315                 320 
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
                325                 330                 335     
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
            340                 345                 350         
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
        355                 360                 365             
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
    370                 375                 380                 
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
385                 390                 395                 400 
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                405                 410                 415     
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
            420                 425                 430         
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
        435                 440                 445             
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
    450                 455                 460                 
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
465                 470                 475                 480 
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                485                 490                 495     
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
            500                 505                 510         
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
        515                 520                 525             
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
    530                 535                 540                 
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
545                 550                 555                 560 
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                565                 570     


<210> 89
<211> 572
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 89
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp Trp
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Ala Trp Ala Ser Ser Leu Tyr Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Gly Trp Gly Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Ser Ala Ser
            100                 105                 110         
Thr Lys Gly Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
        115                 120                 125             
Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe
    130                 135                 140                 
Tyr Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln
145                 150                 155                 160 
Gly Leu Glu Trp Met Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys
                165                 170                 175     
Tyr Val Pro Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser
            180                 185                 190         
Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr
        195                 200                 205             
Ala Val Tyr Tyr Cys Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp
    210                 215                 220                 
Asp Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
225                 230                 235                 240 
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
                245                 250                 255     
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
            260                 265                 270         
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
        275                 280                 285             
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu
    290                 295                 300                 
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
305                 310                 315                 320 
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val
                325                 330                 335     
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro
            340                 345                 350         
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
        355                 360                 365             
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
    370                 375                 380                 
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
385                 390                 395                 400 
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
                405                 410                 415     
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
            420                 425                 430         
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
        435                 440                 445             
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala
    450                 455                 460                 
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
465                 470                 475                 480 
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
                485                 490                 495     
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
            500                 505                 510         
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
        515                 520                 525             
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
    530                 535                 540                 
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
545                 550                 555                 560 
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                565                 570         


<210> 90
<211> 571
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 90
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp Trp
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Gly Trp Gly Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Ser Thr Val
            100                 105                 110         
Ala Ala Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
        115                 120                 125             
Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr
    130                 135                 140                 
Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
145                 150                 155                 160 
Leu Glu Trp Met Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr
                165                 170                 175     
Val Pro Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr
            180                 185                 190         
Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
        195                 200                 205             
Val Tyr Tyr Cys Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp
    210                 215                 220                 
Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
225                 230                 235                 240 
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
                245                 250                 255     
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
            260                 265                 270         
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
        275                 280                 285             
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
    290                 295                 300                 
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
305                 310                 315                 320 
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
                325                 330                 335     
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
            340                 345                 350         
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
        355                 360                 365             
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
    370                 375                 380                 
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
385                 390                 395                 400 
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                405                 410                 415     
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
            420                 425                 430         
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
        435                 440                 445             
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
    450                 455                 460                 
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
465                 470                 475                 480 
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                485                 490                 495     
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
            500                 505                 510         
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
        515                 520                 525             
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
    530                 535                 540                 
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
545                 550                 555                 560 
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                565                 570     


<210> 91
<211> 572
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 91
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp Trp
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Gly Trp Gly Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Ser Ala Ser
            100                 105                 110         
Thr Lys Gly Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
        115                 120                 125             
Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe
    130                 135                 140                 
Tyr Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln
145                 150                 155                 160 
Gly Leu Glu Trp Met Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys
                165                 170                 175     
Tyr Val Pro Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser
            180                 185                 190         
Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr
        195                 200                 205             
Ala Val Tyr Tyr Cys Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp
    210                 215                 220                 
Asp Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
225                 230                 235                 240 
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
                245                 250                 255     
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
            260                 265                 270         
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
        275                 280                 285             
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu
    290                 295                 300                 
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
305                 310                 315                 320 
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val
                325                 330                 335     
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro
            340                 345                 350         
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
        355                 360                 365             
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
    370                 375                 380                 
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
385                 390                 395                 400 
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
                405                 410                 415     
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
            420                 425                 430         
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
        435                 440                 445             
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala
    450                 455                 460                 
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
465                 470                 475                 480 
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
                485                 490                 495     
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
            500                 505                 510         
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
        515                 520                 525             
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
    530                 535                 540                 
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
545                 550                 555                 560 
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                565                 570         


<210> 92
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      

<400> 92
Gly Ser Thr Val Ala Ala Pro Ser
 1               5              


<210> 93
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      

<400> 93
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser
 1               5                  10  


<210> 94
<211> 108
<212> PRT
<213> Homo Sapiens

<220> 
<223> Mutated dAb
      

<400> 94
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp Trp
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Glu Gly Trp Gly Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 95
<211> 324
<212> DNA
<213> Homo Sapiens

<400> 95
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc 60
attacctgca gggccagcag gcccatcagc gactggctgc actggtacca acagaagccc 120
ggcaaggctc ccaagctgct gatcgcctgg gccagcagcc tgcagggagg cgtgcccagc 180
aggtttagcg gcagcggcag cggcaccgac ttcaccctca ccatctcttc cctgcagccc 240
gaggacttcg ccacctacta ctgccagcag gagggctggg ggccccctac tttcggccag 300
ggcaccaagg tggagatcaa gagg                                        324

<210> 96
<211> 581
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 96
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Gly Ser Thr Val Ala Ala Pro Ser Gly
    450                 455                 460                 
Ser Thr Val Ala Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser
465                 470                 475                 480 
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
                485                 490                 495     
Arg Ala Ser Arg Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys
            500                 505                 510         
Pro Gly Lys Ala Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln
        515                 520                 525             
Gly Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
    530                 535                 540                 
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
545                 550                 555                 560 
Cys Gln Gln Glu Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys
                565                 570                 575     
Val Glu Ile Lys Arg
            580     


<210> 97
<211> 1743
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 97
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacgtcga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaagggatc taccgtggca 1380
gcaccatccg gatctaccgt agcagcacca tccggatccg acatccagat gacccagagc 1440
cccagcagcc tgagcgccag cgtgggcgac agggtgacca ttacctgcag ggccagcagg 1500
cccatcagcg actggctgca ctggtaccaa cagaagcccg gcaaggctcc caagctgctg 1560
atcgcctggg ccagcagcct gcagggaggc gtgcccagca ggtttagcgg cagcggcagc 1620
ggcaccgact tcaccctcac catctcttcc ctgcagcccg aggacttcgc cacctactac 1680
tgccagcagg agggctgggg gccccctact ttcggccagg gcaccaaggt ggagatcaag 1740
agg                                                               1743

<210> 98
<211> 589
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 98
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Gly Ser Thr Val Ala Ala Pro Ser Gly
    450                 455                 460                 
Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser Gly
465                 470                 475                 480 
Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                485                 490                 495     
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp
            500                 505                 510         
Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        515                 520                 525             
Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser
    530                 535                 540                 
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
545                 550                 555                 560 
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Glu Gly Trp Gly Pro
                565                 570                 575     
Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            580                 585                 


<210> 99
<211> 1767
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 99
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacgtcga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaagggatc taccgtggca 1380
gcaccatcag gatctaccgt ggcagcacca tcaggttcaa cagtagctgc tccttctgga 1440
tccgacatcc agatgaccca gagccccagc agcctgagcg ccagcgtggg cgacagggtg 1500
accattacct gcagggccag caggcccatc agcgactggc tgcactggta ccaacagaag 1560
cccggcaagg ctcccaagct gctgatcgcc tgggccagca gcctgcaggg aggcgtgccc 1620
agcaggttta gcggcagcgg cagcggcacc gacttcaccc tcaccatctc ttccctgcag 1680
cccgaggact tcgccaccta ctactgccag caggagggct gggggccccc tactttcggc 1740
cagggcacca aggtggagat caagagg                                     1767

<210> 100
<211> 597
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 100
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Gly Ser Thr Val Ala Ala Pro Ser Gly
    450                 455                 460                 
Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser Gly
465                 470                 475                 480 
Ser Thr Val Ala Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser
                485                 490                 495     
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
            500                 505                 510         
Arg Ala Ser Arg Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys
        515                 520                 525             
Pro Gly Lys Ala Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln
    530                 535                 540                 
Gly Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
545                 550                 555                 560 
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
                565                 570                 575     
Cys Gln Gln Glu Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys
            580                 585                 590         
Val Glu Ile Lys Arg
        595         


<210> 101
<211> 1791
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 101
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacgtcga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaagggatc taccgtggca 1380
gcaccatcag gatctaccgt ggcagcacca tcaggttcaa cagtagctgc tccttctggt 1440
tcaacagtag ctgctccttc tggatccgac atccagatga cccagagccc cagcagcctg 1500
agcgccagcg tgggcgacag ggtgaccatt acctgcaggg ccagcaggcc catcagcgac 1560
tggctgcact ggtaccaaca gaagcccggc aaggctccca agctgctgat cgcctgggcc 1620
agcagcctgc agggaggcgt gcccagcagg tttagcggca gcggcagcgg caccgacttc 1680
accctcacca tctcttccct gcagcccgag gacttcgcca cctactactg ccagcaggag 1740
ggctgggggc cccctacttt cggccagggc accaaggtgg agatcaagag g          1791

<210> 102
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 102
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 103
<211> 1731
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 103
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacgtcga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaagaccgt ggcagcacca 1380
tccaccgtag cagcaccatc cggatccgac atccagatga cccagagccc cagcagcctg 1440
agcgccagcg tgggcgacag ggtgaccatt acctgcaggg ccagcaggcc catcagcgac 1500
tggctgcact ggtaccaaca gaagcccggc aaggctccca agctgctgat cgcctgggcc 1560
agcagcctgc agggaggcgt gcccagcagg tttagcggca gcggcagcgg caccgacttc 1620
accctcacca tctcttccct gcagcccgag gacttcgcca cctactactg ccagcaggag 1680
ggctgggggc cccctacttt cggccagggc accaaggtgg agatcaagag g          1731

<210> 104
<211> 583
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 104
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Thr Val Ala Ala Pro Ser Gly Ser Asp Ile Gln Met Thr
465                 470                 475                 480 
Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
                485                 490                 495     
Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp Trp Leu His Trp Tyr Gln
            500                 505                 510         
Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser
        515                 520                 525             
Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
    530                 535                 540                 
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
545                 550                 555                 560 
Tyr Tyr Cys Gln Gln Glu Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly
                565                 570                 575     
Thr Lys Val Glu Ile Lys Arg
            580             


<210> 105
<211> 1749
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 105
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacgtcga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaagaccgt ggcagcacca 1380
tcaaccgtgg cagcaccatc aacagtagct gctccttctg gatccgacat ccagatgacc 1440
cagagcccca gcagcctgag cgccagcgtg ggcgacaggg tgaccattac ctgcagggcc 1500
agcaggccca tcagcgactg gctgcactgg taccaacaga agcccggcaa ggctcccaag 1560
ctgctgatcg cctgggccag cagcctgcag ggaggcgtgc ccagcaggtt tagcggcagc 1620
ggcagcggca ccgacttcac cctcaccatc tcttccctgc agcccgagga cttcgccacc 1680
tactactgcc agcaggaggg ctgggggccc cctactttcg gccagggcac caaggtggag 1740
atcaagagg                                                         1749

<210> 106
<211> 589
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 106
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Thr Val Ala Ala Pro Ser Thr Val Ala Ala Pro Ser Gly
465                 470                 475                 480 
Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                485                 490                 495     
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp
            500                 505                 510         
Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        515                 520                 525             
Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser
    530                 535                 540                 
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
545                 550                 555                 560 
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Glu Gly Trp Gly Pro
                565                 570                 575     
Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            580                 585                 


<210> 107
<211> 1767
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 107
caggtgcagc tcgtgcagag cggcgccgaa gtgaaaaagc ccggcagcag cgtgaaggtg 60
agctgcaagg cctccggctt ctacatcaag gacacctaca tgcactgggt caggcaggct 120
cctggccagg gcctggagtg gatgggcact atcgaccccg ccaacggcaa caccaagtac 180
gtgcccaagt tccagggcag ggtgaccatc accgccgatg agagcaccag caccgcctac 240
atggaactga gcagcctgag gtctgaggac accgccgtgt actattgcgc caggagcatc 300
tacgacgact accacgtcga cgactactac gccatggact actggggaca gggcacacta 360
gtgaccgtgt ccagcgccag caccaagggc cccagcgtgt tccccctggc ccccagcagc 420
aagagcacca gcggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa 480
ccggtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc 600
ctgggcaccc agacctacat ctgtaacgtg aaccacaagc ccagcaacac caaggtggac 660
aagaaggtgg agcccaagag ctgtgacaag acccacacct gccccccctg ccctgccccc 720
gagctgctgg gaggccccag cgtgttcctg ttccccccca agcctaagga caccctgatg 780
atcagcagaa cccccgaggt gacctgtgtg gtggtggatg tgagccacga ggaccctgag 840
gtgaagttca actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg 900
gaggagcagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat 960
tggctgaacg gcaaggagta caagtgtaag gtgtccaaca aggccctgcc tgcccctatc 1020
gagaaaacca tcagcaaggc caagggccag cccagagagc cccaggtgta caccctgccc 1080
cctagcagag atgagctgac caagaaccag gtgtccctga cctgcctggt gaagggcttc 1140
taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 1200
accacccccc ctgtgctgga cagcgatggc agcttcttcc tgtacagcaa gctgaccgtg 1260
gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg 1320
cacaatcact acacccagaa gagcctgagc ctgtcccctg gcaagaccgt ggcagcacca 1380
tcaaccgtgg cagcaccatc aacagtagct gctccttcta cagtagctgc tccttctgga 1440
tccgacatcc agatgaccca gagccccagc agcctgagcg ccagcgtggg cgacagggtg 1500
accattacct gcagggccag caggcccatc agcgactggc tgcactggta ccaacagaag 1560
cccggcaagg ctcccaagct gctgatcgcc tgggccagca gcctgcaggg aggcgtgccc 1620
agcaggttta gcggcagcgg cagcggcacc gacttcaccc tcaccatctc ttccctgcag 1680
cccgaggact tcgccaccta ctactgccag caggagggct gggggccccc tactttcggc 1740
cagggcacca aggtggagat caagagg                                     1767

<210> 108
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 108
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Asn Ile Val His Ile
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Ile Ser Asp Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 


<210> 109
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 109
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggcgt gcacagcgac 60
atccagatga cccagagccc cagcagcctg agcgccagcg tgggcgacag ggtgactatc 120
acctgcagga gcagccagaa catcgtgcac atcaacggca acacctacct cgagtggtac 180
cagcagaaac ccgggaaggc ccccaagctg ctgatctaca agatcagcga caggttcagc 240
ggcgtgccca gcaggtttag cggctccggc tcaggcaccg atttcaccct gaccattagc 300
agcctgcagc ccgaggactt cgccacctac tactgcttcc agggctctca cgtcccctgg 360
accttcggcc agggcaccaa gctggagatc aagcgtacgg tggccgcccc cagcgtgttc 420
atcttccccc ccagcgatga gcagctgaag agcggcaccg ccagcgtggt gtgtctgctg 480
aacaacttct acccccggga ggccaaggtg cagtggaagg tggacaatgc cctgcagagc 540
ggcaacagcc aggagagcgt gaccgagcag gacagcaagg actccaccta cagcctgagc 600
agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgtgaggtg 660
acccaccagg gcctgtccag ccccgtgacc aagagcttca accggggcga gtgc       714

<210> 110
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 110
Asp Val Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Asn Ile Val His Ile
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Ile Ser Asp Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 


<210> 111
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 111
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggcgt gcacagcgac 60
gtgctgatga cccagagccc cagcagcctg agcgccagcg tgggcgacag ggtgactatc 120
acctgcagga gcagccagaa catcgtgcac atcaacggca acacctacct cgagtggtac 180
cagcagaaac ccgggaaggc ccccaagctg ctgatctaca agatcagcga caggttcagc 240
ggcgtgccca gcaggtttag cggctccggc tcaggcaccg atttcaccct gaccattagc 300
agcctgcagc ccgaggactt cgccacctac tactgcttcc agggctctca cgtcccctgg 360
accttcggcc agggcaccaa gctggagatc aagcgtacgg tggccgcccc cagcgtgttc 420
atcttccccc ccagcgatga gcagctgaag agcggcaccg ccagcgtggt gtgtctgctg 480
aacaacttct acccccggga ggccaaggtg cagtggaagg tggacaatgc cctgcagagc 540
ggcaacagcc aggagagcgt gaccgagcag gacagcaagg actccaccta cagcctgagc 600
agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgtgaggtg 660
acccaccagg gcctgtccag ccccgtgacc aagagcttca accggggcga gtgc       714

<210> 112
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 112
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Asn Ile Val His Ile
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asp Arg Phe Ser Gly Ile Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
65                  70                  75                  80  
Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 


<210> 113
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 113
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggcgt gcacagcgag 60
atcgtgctga cccagagccc tggcacactg agcctgagcc ccggagagag ggccaccctg 120
agctgcaggt ctagccagaa catcgtgcac atcaacggca acacctacct ggagtggtat 180
cagcagaagc ccggccaggc ccccaggctg ctgatctaca agatcagcga caggttcagc 240
ggcatccccg acaggtttag cggcagcggc agcggcaccg acttcaccct gaccattagc 300
aggctggagc ccgaggactt cgccgtgtac tactgcttcc aggggagcca cgtgccctgg 360
accttcggcc agggcaccaa gctcgaaatc aagcgtacgg tggccgcccc cagcgtgttc 420
atcttccccc ccagcgatga gcagctgaag agcggcaccg ccagcgtggt gtgtctgctg 480
aacaacttct acccccggga ggccaaggtg cagtggaagg tggacaatgc cctgcagagc 540
ggcaacagcc aggagagcgt gaccgagcag gacagcaagg actccaccta cagcctgagc 600
agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgtgaggtg 660
acccaccagg gcctgtccag ccccgtgacc aagagcttca accggggcga gtgc       714

<210> 114
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 114
Asp Val Leu Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Asn Ile Val His Ile
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Ile Ser Asp Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
65                  70                  75                  80  
Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 


<210> 115
<211> 657
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 115
gacgtgctga tgacccagag ccctggcaca ctgagcctga gccccggaga gagggccacc 60
ctgagctgca ggtctagcca gaacatcgtg cacatcaacg gcaacaccta cctggagtgg 120
tatcagcaga agcccggcca ggcccccaag ctgctgatct acaagatcag cgacaggttc 180
agcggcgtgc ccgacaggtt tagcggcagc ggcagcggca ccgacttcac cctgaccatt 240
agcaggctgg agcccgagga cttcgccgtg tactactgct tccaggggag ccacgtgccc 300
tggaccttcg gccagggcac caagctcgaa atcaagcgta cggtggccgc ccccagcgtg 360
ttcatcttcc cccccagcga tgagcagctg aagagcggca ccgccagcgt ggtgtgtctg 420
ctgaacaact tctacccccg ggaggccaag gtgcagtgga aggtggacaa tgccctgcag 480
agcggcaaca gccaggagag cgtgaccgag caggacagca aggactccac ctacagcctg 540
agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag 600
gtgacccacc agggcctgtc cagccccgtg accaagagct tcaaccgggg cgagtgc    657

<210> 116
<211> 571
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 116
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Gly Ser Asp
    450                 455                 460                 
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
465                 470                 475                 480 
Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp Trp Leu
                485                 490                 495     
His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ala
            500                 505                 510         
Trp Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly Ser
        515                 520                 525             
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
    530                 535                 540                 
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Gly Trp Gly Pro Pro Thr
545                 550                 555                 560 
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                565                 570     


<210> 117
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 117
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 118
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 118
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 119
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 119
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 120
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 120
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 121
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 121
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 122
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 122
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Thr Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 123
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 123
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Cys Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 124
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 124
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 125
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 125
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Trp Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 126
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 126
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Glu Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 127
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 127
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Lys Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 128
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 128
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Asp Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 129
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 129
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Asn Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 130
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 130
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 131
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 131
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 132
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 132
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ile Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 133
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 133
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 134
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 134
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Pro Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    


<210> 135
<211> 573
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 135
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Gly Ser Thr Val Ala Ala Pro Ser Gly
    450                 455                 460                 
Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
465                 470                 475                 480 
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp
                485                 490                 495     
Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
            500                 505                 510         
Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser
        515                 520                 525             
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
    530                 535                 540                 
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Gly Trp Gly Pro
545                 550                 555                 560 
Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                565                 570             


<210> 136
<211> 581
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 136
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Gly Ser Thr Val Ala Ala Pro Ser Gly
    450                 455                 460                 
Ser Thr Val Ala Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser
465                 470                 475                 480 
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
                485                 490                 495     
Arg Ala Ser Arg Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys
            500                 505                 510         
Pro Gly Lys Ala Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln
        515                 520                 525             
Gly Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
    530                 535                 540                 
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
545                 550                 555                 560 
Cys Leu Gln Glu Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys
                565                 570                 575     
Val Glu Ile Lys Arg
            580     


<210> 137
<211> 589
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 137
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Gly Ser Thr Val Ala Ala Pro Ser Gly
    450                 455                 460                 
Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser Gly
465                 470                 475                 480 
Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                485                 490                 495     
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp
            500                 505                 510         
Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        515                 520                 525             
Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser
    530                 535                 540                 
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
545                 550                 555                 560 
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Gly Trp Gly Pro
                565                 570                 575     
Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            580                 585                 


<210> 138
<211> 597
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      

<400> 138
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Tyr Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Gly Ser Thr Val Ala Ala Pro Ser Gly
    450                 455                 460                 
Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser Gly
465                 470                 475                 480 
Ser Thr Val Ala Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser
                485                 490                 495     
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
            500                 505                 510         
Arg Ala Ser Arg Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys
        515                 520                 525             
Pro Gly Lys Ala Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln
    530                 535                 540                 
Gly Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
545                 550                 555                 560 
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
                565                 570                 575     
Cys Leu Gln Glu Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys
            580                 585                 590         
Val Glu Ile Lys Arg
        595         


<210> 139
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      

<400> 139
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser
 1               5                  10  


<210> 140
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      

<400> 140
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser
        


<210> 141
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      

<400> 141
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser
            20                  25      


<210> 142
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      

<400> 142
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
            20                  25                  30          
Gly Ser
        


<210> 143
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      

<400> 143
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
            20                  25                  30          
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser
        35                  40          


<210> 144
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      

<400> 144
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
            20                  25                  30          
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
        35                  40                  45              
Gly Ser
    50  


<210> 145
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      

<400> 145
Thr Val Ala Ala Pro Ser Thr Val Ala Ala Pro Ser Gly Ser
 1               5                  10                  


<210> 146
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      

<400> 146
Thr Val Ala Ala Pro Ser Thr Val Ala Ala Pro Ser Thr Val Ala Ala
 1               5                  10                  15      
Pro Ser Gly Ser
            20  


<210> 147
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fusion protein

<400> 147
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Tyr Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Thr Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ile Tyr Asp Asp Tyr His Val Asp Asp Tyr Tyr Ala Met
            100                 105                 110         
Asp Tyr Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys Thr Val Ala Ala Pro Ser Thr Val Ala
    450                 455                 460                 
Ala Pro Ser Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
465                 470                 475                 480 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
                485                 490                 495     
Pro Ile Ser Asp Trp Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
            500                 505                 510         
Pro Lys Leu Leu Ile Ala Trp Ala Ser Ser Leu Gln Gly Gly Val Pro
        515                 520                 525             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    530                 535                 540                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Glu
545                 550                 555                 560 
Gly Trp Gly Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                565                 570                 575     
Arg
    

