
SEQUENCE LISTING

<110> INSTITUTE FOR SYSTEMS BIOLOGY
      MIAO, Edward A.
      ADEREM, Alan A.

<120> SECRETION-RELATED BACTERIAL PROTEINS FOR NLRC4
      STIMULATION

<130> 655652000440

<140> PCT/US2010/035855   
<141> 2010-05-21  

<150> US 61/180,762       
<151> 2009-05-22  

<160> 31

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 63
<212> PRT
<213> Salmonella typhimurium

<220> 
<221> misc_feature    
<222> (1)...(63)
<223> PrgJ (NP_461793)

<400> 1
Gly Ser Ala Ile Ala Thr Ala Val Asp Lys Gln Thr Ile Thr Asn Arg
 1               5                  10                  15      
Ile Glu Asp Pro Asn Leu Val Thr Asp Pro Lys Glu Leu Ala Ile Ser
            20                  25                  30          
Gln Glu Met Ile Ser Asp Tyr Asn Leu Tyr Val Ser Met Val Ser Thr
        35                  40                  45              
Leu Thr Arg Lys Gly Val Gly Ala Val Glu Thr Leu Leu Arg Ser
    50                  55                  60              


<210> 2
<211> 64
<212> PRT
<213> Burkholderia pseudomallei

<220> 
<221> misc_feature         
<222> (1)...(64)
<223> BsaK (YP_001076126)

<400> 2
Asp Ala Asn Glu Lys Ser Asn Ala Ala Lys Thr Ser Ile Glu Ser Arg
 1               5                  10                  15      
Leu Ala Asp Pro Val Asp Phe Ala Gln Ser Glu Lys Leu Ile Ala Leu
            20                  25                  30          
Gln Thr Glu Leu Ser Asp Tyr Ser Ile Tyr Val Ser Leu Ala Ser Thr
        35                  40                  45              
Leu Ala Arg Lys Ala Val Ser Ala Val Glu Thr Leu Val Lys Ala Gln
    50                  55                  60                  


<210> 3
<211> 62
<212> PRT
<213> Shigella flexneri

<220> 
<221> misc_feature         
<222> (1)...(62)
<223> MxiI (NP_085301)

<400> 3
Asp Ile Lys Met Asp Thr Asp Ile Gln Val Ser Gln Ile Met Glu Met
 1               5                  10                  15      
Val Ser Asn Pro Glu Ser Leu Asn Pro Glu Ser Leu Ala Lys Leu Gln
            20                  25                  30          
Thr Thr Leu Ser Asn Tyr Ser Ile Gly Val Ser Leu Ala Gly Thr Leu
        35                  40                  45              
Ala Arg Lys Thr Val Ser Ala Val Glu Thr Leu Leu Lys Ser
    50                  55                  60          


<210> 4
<211> 63
<212> PRT
<213> Escherichia coli

<220> 
<221> misc_feature         
<222> (1)...(63)
<223> EprJ (NP_289414)

<400> 4
Asn Tyr Ala Val Gln Thr Glu Asn Trp Gln Gln Asn Ala Leu Gln Ala
 1               5                  10                  15      
Leu Arg Ser Asp Lys Lys Gly Leu Thr Pro Glu Lys Leu Leu Val Leu
            20                  25                  30          
Gln Asp His Val Leu Asn Tyr Asn Val Glu Val Pro Leu Val Gly Thr
        35                  40                  45              
Leu Ala Arg Lys Ile Val Ala Ala Val Glu Thr Leu Thr Arg Ser
    50                  55                  60              


<210> 5
<211> 75
<212> PRT
<213> Escherichia coli

<220> 
<221> misc_feature        
<222> (1)...(75)
<223> EscI (CAX18737)

<400> 5
Gly Val Ser Ser Pro Glu Gln Val Leu Ile Glu Glu Ile Lys Lys Arg
 1               5                  10                  15      
His Leu Ala Thr Met Asn Thr Asp Leu Ser Phe Asp Ala Leu Ser Ala
            20                  25                  30          
Gly Gly Leu Ser Pro Glu Asp Val Leu Thr Leu Gln Lys Asn Val Leu
        35                  40                  45              
Asn Ala Asn Val Asn Val Asp Val Val Ser Lys Leu Ala Ser Leu Leu
    50                  55                  60                  
Ser Thr Ser Val Thr Lys Leu Val Ser Met Gln
65                  70                  75  


<210> 6
<211> 51
<212> PRT
<213> Salmonella tymphimurium

<220> 
<221> misc_feature         
<222> (1)...(51)
<223> SsaI (NP_460373)

<400> 6
Asp Glu Ala Ser Thr Ser Asn Ala Ser Ala Leu Leu Pro Gln Val Met
 1               5                  10                  15      
Leu Thr Arg Gln Met Asp Tyr Met Gln Leu Thr Val Gly Val Asp Tyr
            20                  25                  30          
Leu Ala Arg Ile Ser Gly Ala Ala Ser Gln Ala Leu Asn Lys Leu Asp
        35                  40                  45              
Asn Met Ala
    50      


<210> 7
<211> 41
<212> PRT
<213> Vibrio cholerae

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> AM-19226 (A33_1694)

<400> 7
Met Ser Ala Val Thr Ala Leu Arg Leu Thr Gln Asp Val Phe His Tyr
 1               5                  10                  15      
Ala Ile Tyr Gln Glu Thr Val Thr Lys Ile Ala Val Lys Ala Ala Asn
            20                  25                  30          
Ala Ile Asn Asp Val Ala Lys Ala Gln
        35                  40      


<210> 8
<211> 41
<212> PRT
<213> Vibrio parahaemolyticus

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> VPA1368 (NP_800878)

<400> 8
Met Ser Ala Val Asp Ala Leu Arg Leu Gln Gln Glu Val Phe His Tyr
 1               5                  10                  15      
Ser Ile Tyr Gln Glu Thr Val Thr Lys Ile Ala Ser Lys Ala Ala Thr
            20                  25                  30          
Ala Val Asn Glu Val Met Lys Ala Gln
        35                  40      


<210> 9
<211> 41
<212> PRT
<213> Burkholderia pseudomallei

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> BURPS1106A_A1902

<400> 9
Glu Val Asn Val Glu Thr Ile Arg Leu Thr Tyr Glu Ile Ala Ser Thr
 1               5                  10                  15      
Gln Leu Asp Met Glu Ala Lys Met Ser Val Val Asn Ala Ser Lys Thr
            20                  25                  30          
Ala Ile Glu Thr Leu Met Lys Asn Gln
        35                  40      


<210> 10
<211> 41
<212> PRT
<213> Burkholderia pseudomallei

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> BURPS1106A_A2201

<400> 10
Gln Met Phe Ala Ala Ser Leu Gln Ala Ser Ala Glu Ala Thr Ala Met
 1               5                  10                  15      
Gln Ile Asp Met Gln Ala Lys Met Gly Val Val Thr Ser Thr Lys Asp
            20                  25                  30          
Ala Ile Gly Ser Leu Met Lys Asn Gln
        35                  40      


<210> 11
<211> 41
<212> PRT
<213> Aeromonas salmonicida

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> ascI (YP_001144273)

<400> 11
Asp Asp Pro Asn Ser Leu Met Gln Met Gln Trp Ser Leu Met Arg Ile
 1               5                  10                  15      
Thr Met Gln Glu Glu Leu Ile Ala Lys Thr Val Gly Lys Met Ser Gln
            20                  25                  30          
Asn Val Glu Thr Leu Leu Lys Thr Gln
        35                  40      


<210> 12
<211> 41
<212> PRT
<213> Aeromonas hydrophila

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> yscI (AAV30248)

<400> 12
Asp Asp Pro Asn Ser Leu Met Gln Met Gln Trp Ser Leu Met Arg Ile
 1               5                  10                  15      
Thr Met Gln Glu Glu Leu Ile Ala Lys Thr Val Gly Lys Met Ser Gln
            20                  25                  30          
Asn Val Glu Thr Leu Leu Lys Thr Gln
        35                  40      


<210> 13
<211> 41
<212> PRT
<213> Pseudomonas aeruginosa

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> PscI (NP_250413)

<400> 13
Asp Asp Pro Asn Ser Leu Met Gln Met Gln Trp Ser Leu Met Arg Ile
 1               5                  10                  15      
Thr Met Gln Glu Glu Leu Ile Ala Lys Thr Val Gly Arg Met Ser Gln
            20                  25                  30          
Asn Val Glu Thr Leu Met Lys Thr Gln
        35                  40      


<210> 14
<211> 41
<212> PRT
<213> Yersinia pestis

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> yscI (NP_395192)

<400> 14
Asp Asn Pro Asn Asp Leu Met Leu Met Gln Trp Ser Leu Ile Arg Ile
 1               5                  10                  15      
Thr Ile Gln Glu Glu Leu Ile Ala Lys Thr Ala Gly Arg Met Ser Gln
            20                  25                  30          
Asn Val Glu Thr Leu Ser Lys Gly Gly
        35                  40      


<210> 15
<211> 41
<212> PRT
<213> Vibrio parahaemolyticus

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> VP1691 (NP_798070)

<400> 15
Asp Asp Pro Ala Gln Leu Leu Gln Met Gln Trp Ala Leu Thr Arg Ile
 1               5                  10                  15      
Thr Phe Gln Glu Glu Leu Ile Ala Lys Thr Val Gly Lys Thr Thr Gln
            20                  25                  30          
Asn Val Glu Thr Leu Leu Lys Ala Gln
        35                  40      


<210> 16
<211> 41
<212> PRT
<213> Burkholderia thailandensis

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> Bpse38 (ZP_02468967)

<400> 16
Ala Ser Pro Leu Glu Met Leu Ala Thr Gln Ser Thr Met Leu Arg Ser
 1               5                  10                  15      
Ile Val Glu Val Asp Leu Met Ala Lys Thr Ala Gly Ala Val Ser Gln
            20                  25                  30          
Gly Val Asn Lys Leu Val Asn Met Gln
        35                  40      


<210> 17
<211> 39
<212> PRT
<213> Yersinia pestis

<220> 
<221> misc_feature         
<222> (1)...(39)
<223> CO92 (YP_002345343.1)

<400> 17
Pro Glu Ser Leu Leu Met Gln Gln Ala Glu Trp Met His Ala Ser Leu
 1               5                  10                  15      
Ala Ile Asp Leu Thr Ala Lys Val Ala Gly Val Met Gly Gln Asn Ile
            20                  25                  30          
Asn Lys Leu Val Asn Met Gln
        35                  


<210> 18
<211> 39
<212> PRT
<213> Yersinia pseudotuberculosis

<220> 
<221> misc_feature         
<222> (1)...(39)
<223> hrpB (YP_001402778)

<400> 18
Pro Glu Ser Leu Leu Met Gln Gln Ala Glu Trp Met His Ala Ser Leu
 1               5                  10                  15      
Ala Ile Asp Leu Thr Ala Lys Val Ala Gly Val Met Gly Gln Asn Ile
            20                  25                  30          
Asn Lys Leu Val Asn Met Gln
        35                  


<210> 19
<211> 41
<212> PRT
<213> Salmonella typhimurium

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> SsaI (NP_460373)

<400> 19
Leu Leu Pro Gln Val Met Leu Thr Arg Gln Met Asp Tyr Met Gln Leu
 1               5                  10                  15      
Thr Val Gly Val Asp Tyr Leu Ala Arg Ile Ser Gly Ala Ala Ser Gln
            20                  25                  30          
Ala Leu Asn Lys Leu Asp Asn Met Ala
        35                  40      


<210> 20
<211> 41
<212> PRT
<213> Escherichia coli

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> EscI (CAX18737)

<400> 20
Leu Ser Pro Glu Asp Val Leu Thr Leu Gln Lys Asn Val Leu Asn Ala
 1               5                  10                  15      
Asn Val Asn Val Asp Val Val Ser Lys Leu Ala Ser Leu Leu Ser Thr
            20                  25                  30          
Ser Val Thr Lys Leu Val Ser Met Gln
        35                  40      


<210> 21
<211> 41
<212> PRT
<213> Citrobacter rodentium

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> rc (AAL06365)

<400> 21
Leu Ser Ile Glu Glu Leu Arg Ile Leu Gln Lys Lys Val Leu Asn Ala
 1               5                  10                  15      
Asn Val Asn Val Asp Val Leu Ser Lys Phe Ala Ser Leu Leu Ser Thr
            20                  25                  30          
Ser Leu Thr Lys Leu Ile Ser Gln Gln
        35                  40      


<210> 22
<211> 41
<212> PRT
<213> Bordatella pertussis

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> bscI 1 (NP_880892)

<400> 22
Pro Thr Val Val Gly Met Leu Asp Leu Gln Ala Arg Leu Leu Gln Ala
 1               5                  10                  15      
Ser Val Glu Tyr Glu Leu Val Gly Lys Ala Ile Gly Arg Ala Thr Gln
            20                  25                  30          
Asn Val Asp Thr Leu Ala Arg Met Ser
        35                  40      


<210> 23
<211> 41
<212> PRT
<213> Burkholderia pseudomallei

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> BsaK (YP_001076126)

<400> 23
Ala Gln Ser Glu Lys Leu Ile Ala Leu Gln Thr Glu Leu Ser Asp Tyr
 1               5                  10                  15      
Ser Ile Tyr Val Ser Leu Ala Ser Thr Leu Ala Arg Lys Ala Val Ser
            20                  25                  30          
Ala Val Glu Thr Leu Val Lys Ala Gln
        35                  40      


<210> 24
<211> 40
<212> PRT
<213> Chromobacterium violaceum

<220> 
<221> misc_feature         
<222> (1)...(40)
<223> PrgJ (NP_902091)

<400> 24
Thr Asp Pro Lys Glu Leu Ala Ile Ser Gln Glu Met Ile Ser Asp Tyr
 1               5                  10                  15      
Asn Leu Tyr Val Ser Met Val Ser Thr Leu Thr Arg Lys Gly Val Gly
            20                  25                  30          
Ala Val Glu Thr Leu Leu Arg Ser
        35                  40  


<210> 25
<211> 40
<212> PRT
<213> Escherichia coli

<220> 
<221> misc_feature         
<222> (1)...(40)
<223> EprJ (NP_289414)

<400> 25
Leu Thr Pro Glu Lys Leu Leu Val Leu Gln Asp His Val Leu Asn Tyr
 1               5                  10                  15      
Asn Val Glu Val Pro Leu Val Gly Thr Leu Ala Arg Lys Ile Val Ala
            20                  25                  30          
Ala Val Glu Thr Leu Thr Arg Ser
        35                  40  


<210> 26
<211> 40
<212> PRT
<213> Shigella flexneri

<220> 
<221> misc_feature         
<222> (1)...(40)
<223> MxiI (NO_085301)
      

<400> 26
Leu Asn Pro Glu Ser Leu Ala Lys Leu Gln Thr Thr Leu Ser Asn Tyr
 1               5                  10                  15      
Ser Ile Gly Val Ser Leu Ala Gly Thr Leu Ala Arg Lys Thr Val Ser
            20                  25                  30          
Ala Val Glu Thr Leu Leu Lys Ser
        35                  40  


<210> 27
<211> 41
<212> PRT
<213> Yersinia enterocolitica

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> ysaI (AAK84118)

<400> 27
Ser Asn Pro Ser Glu Leu Leu Gln Phe Gln Ser Arg Met Asn Asn Tyr
 1               5                  10                  15      
Asn His Ala Ile Asn Phe Ile Ala Thr Leu Thr His Lys Gly Ala Ser
            20                  25                  30          
Ala Ile Asp Ser Val Leu Lys Ala Pro
        35                  40      


<210> 28
<211> 41
<212> PRT
<213> Pseudomonas syringae pv tomato

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> hrpB (NP_791210)

<400> 28
Glu Asp Pro Gly Asp Ile Val Gln Met Ser Arg Ala Leu Ser Gln Cys
 1               5                  10                  15      
Ser Leu Gln Met Ala Leu Thr Thr Lys Val Val Ser Lys Ser Ala Gln
            20                  25                  30          
Ala Leu Asp Lys Leu Thr Asn Leu Gln
        35                  40      


<210> 29
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetically constructed consensus sequence

<220> 
<221> VARIANT        
<222> (1)...(39)
<223> Xaa = any regular amino acid

<400> 29
Pro Xaa Xaa Leu Leu Xaa Leu Gln Xaa Xaa Leu Met Xaa Xaa Ser Ile
 1               5                  10                  15      
Xaa Val Glu Leu Ile Ala Lys Leu Ala Xaa Lys Xaa Ser Gln Ala Val
            20                  25                  30          
Glu Thr Leu Leu Lys Xaa Gln
        35                  


<210> 30
<211> 37
<212> PRT
<213> Salmonella typhimurium

<220> 
<221> misc_feature         
<222> (1)...(37)
<223> FliC (PO6179)

<400> 30
Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala Gln Ile
 1               5                  10                  15      
Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro
            20                  25                  30          
Gln Asn Val Leu Ser
        35          


<210> 31
<211> 41
<212> PRT
<213> Salmonella typhimurium

<220> 
<221> misc_feature         
<222> (1)...(41)
<223> PrgJ (NP_461793)

<400> 31
Val Thr Asp Pro Lys Glu Leu Ala Ile Ser Gln Glu Met Ile Ser Asp
 1               5                  10                  15      
Tyr Asn Leu Tyr Val Ser Met Val Ser Thr Leu Thr Arg Lys Gly Val
            20                  25                  30          
Gly Ala Val Glu Thr Leu Leu Arg Ser
        35                  40      

