
                         SEQUENCE LISTING

<110>  Celldex Therapeutics, Inc. et al.
 
<120>  Antibodies Directed to GPNMB and Uses Thereof

<130>  21402-669003WO

<150>  US 61/179,813
<151>  2009-05-20

<160>  272   

<170>  PatentIn version 3.2

<210>  1
<211>  347
<212>  DNA
<213>  Homo sapiens

<400>  1
aggtgcagct gcaggagtcg ggcccaggac tggtgaagcc ttcggagacc ctgtccctca     60

cctgcactgt ctctggtgac tccatcagta attactactg gagctggatc cggcagcccc    120

cagggaaggg actggagtgg attgggtatt tctattacag tgggagcacc aactacaacc    180

cctccctcaa gagtcgagtc accatatcag tagacacgtc caagaaccag ttctccctga    240

aactgagctc tgtgaccgct gcggacacgg ccgtgtatta ctgtgcgaga gataggggct    300

gggctgacta ctggggccag ggaaccctgg tcaccgtctc ctcagcc                  347


<210>  2
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Gly Trp Ala Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  3
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  4
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Asp Ser Ile Ser Asn Tyr Tyr Trp Ser 
1               5                   10  


<210>  5
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  5

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  6
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  6

Tyr Phe Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  7
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  8
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Arg Gly Trp Ala Asp Tyr 
1               5           


<210>  9
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  9

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  10
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  10
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagggccacc     60

ctctcctgca gaaccagtca gagtattagc agcagctatt tagcctggta ccagcagaaa    120

cctggccagg ttcccaggct cctcatctat ggtgcttcca gcagggccac tggcatccca    180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcagtgta ttattgtcag cagtatggta gctcgatcac cttcggccaa    300

gggacacgac tggagattaa acga                                           324


<210>  11
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ser Ile Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210>  12
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  13
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Thr Ser Gln Ser Ile Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  14
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  14

Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  15
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  16
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  17
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Gln Tyr Gly Ser Ser Ile Thr 
1               5               


<210>  18
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  18

Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
1               5                   10      


<210>  19
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  19
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agttttaatt actactggag ctggatccgc    120

caccacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tccaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgacgc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagaggg    300

tataactgga actactttga ctactggggc cagggaaccc tggtcaccgt ctcctcagcc    360


<210>  20
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Phe 
            20                  25                  30          


Asn Tyr Tyr Trp Ser Trp Ile Arg His His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Ser Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Thr Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Tyr Asn Trp Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  21
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser 
            20                  25                  30  


<210>  22
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Phe Asn Tyr Tyr Trp Ser 
1               5           


<210>  23
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  23

Trp Ile Arg His His Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  24
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  24

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Ser Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  25
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Thr 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Tyr Asn Trp Asn Tyr Phe Asp Tyr 
1               5                   


<210>  27
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  27

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  28
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  28
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttgac aacaacttag tctggtacca gcagaaacct    120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc    180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagtag tctgcagtct    240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctccgtg gacgttcggc    300

caagggacca aggtggaaat caaacga                                        327


<210>  29
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Asn Asn 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  30
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  31
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  31

Arg Ala Ser Gln Ser Val Asp Asn Asn Leu Val 
1               5                   10      


<210>  32
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  32

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  33
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  34
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  35
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Gln Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  36
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  36

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  37
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  37
atcaccttga aggagtctgg tcctacgctg gtgaaaccca cacagaccct cacgctgacc     60

tgcaccttct ctgggttctc actcagcgct ggtggagtgg gtgtgggctg gatccgtcag    120

cccccaggaa aggccctgga gtggcttgca ctcatttatt ggaatgatga taagcgctac    180

agcccatctc tgaggagcag gctcaccatc accaaggaca cctccaaaaa ccaggtggtc    240

cttacaatta ccaacatgga ccctgtggac acagccacat attattgtgc acacagtcac    300

tatgattacg attgggggag ttactttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctcagcc                                                            369


<210>  38
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  38

Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Ala Gly Gly 
            20                  25                  30          


Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp 
        35                  40                  45              


Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Ile Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala His Ser His Tyr Asp Tyr Asp Trp Gly Ser Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120             


<210>  39
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  39

Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Phe Ser 
            20                  


<210>  40
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  40

Gly Phe Ser Leu Ser Ala Gly Gly Val Gly Val Gly 
1               5                   10          


<210>  41
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  41

Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala 
1               5                   10                  


<210>  42
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  42

Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210>  43
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  43

Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr 
1               5                   10                  15      


Ile Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala His 
            20                  25                  30          


<210>  44
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  44

Ser His Tyr Asp Tyr Asp Trp Gly Ser Tyr Phe Asp Tyr 
1               5                   10              


<210>  45
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  45

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  46
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  46
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc     60

atctcctgca ggtctagtca gagcctcttg gatagtgatg atggaaacac ctatttggac    120

tggtacctgc agaagccagg acagtctcca cagctcctga tctatacgct ttcctatcgg    180

gcctctggag tcccagacag gttcagtggc agtgggtcag gcactgattt cacactgaac    240

atcagcaggg tggaggctga ggatgttgga gtttattact gcatgcaacg tatagagttt    300

cctatcacct tcggccaagg gacacgactg gagattaaac ga                       342


<210>  47
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  47

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Glu Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  48
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  48

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  49
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  49

Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu 
1               5                   10                  15      


Asp 
    


<210>  50
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  50

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  51
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  51

Thr Leu Ser Tyr Arg Ala Ser 
1               5           


<210>  52
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  52

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Asn Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  53
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Gln Arg Ile Glu Phe Pro Ile Thr 
1               5                   


<210>  54
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  54

Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
1               5                   10      


<210>  55
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  55
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtgctaatt actactggac ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tgcaacccgt ccctcaagag tcgagttatc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagaggg    300

tataactgga actactttga ctactggggc cagggaaccc tggtcaccgt ctcctcagcc    360


<210>  56
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ala 
            20                  25                  30          


Asn Tyr Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Cys Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ile Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Tyr Asn Trp Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  57
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  57

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val 
            20                  


<210>  58
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  58

Gly Gly Ser Ile Ser Ser Ala Asn Tyr Tyr Trp Thr 
1               5                   10          


<210>  59
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  59

Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  60
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  60

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Cys Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  61
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  61

Arg Val Ile Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  62
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  62

Gly Tyr Asn Trp Asn Tyr Phe Asp Tyr 
1               5                   


<210>  63
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  63

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  64
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  64
gatatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca ggagagacct    120

ggccaggctc ccagactcct catctatggt gcatccacca gggccactgg tatcccagcc    180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct    240

gaagattttg cagtttatta ctgtcagcag tataataagt ggcctccgtg gacgttcggc    300

caagggacca aggtggaaat cgaacgaact                                     330


<210>  65
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  65

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Lys Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Glu Arg 
            100                 105                 


<210>  66
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  66

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  67
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  67

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  68
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  68

Trp Tyr Gln Glu Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  69
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  69

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  70
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  70

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  71
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  71

Gln Gln Tyr Asn Lys Trp Pro Pro Trp Thr 
1               5                   10  


<210>  72
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  72

Phe Gly Gln Gly Thr Lys Val Glu Ile Glu Arg 
1               5                   10      


<210>  73
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  73
cagctggtgg agtctggggg aggcgtggtc cagcctggga ggtccctgag actctcctgt     60

gcagcctctg gattcgcctt cagtagctat ggcatgcact gggtccgcca ggctccaggc    120

aaggggctgg agtgggtggc agttatatca tatgatggaa ataataaata ctatgcagac    180

tccgtgaagg gccgattcac catctccaga gacaattcca agaacacgct gtatctgcaa    240

atgaacagcc tgagagctga ggacacggct gtgtattact gtgcgagaga tctagtggtt    300

cggggaatta gggggtacta ctactacttc ggtatggacg tctggggcca agggaccacg    360

gtcaccgtct cctcagcc                                                  378


<210>  74
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  74

Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr Gly Met 
            20                  25                  30          


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val 
        35                  40                  45              


Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Leu Val Val Arg Gly Ile Arg Gly Tyr Tyr Tyr Tyr Phe Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125     


<210>  75
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  75

Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser 
            20              


<210>  76
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  76

Gly Phe Ala Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  77
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  77

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  78
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  78

Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  79

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  80
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  80

Asp Leu Val Val Arg Gly Ile Arg Gly Tyr Tyr Tyr Tyr Phe Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  81
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  81

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  82
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  82
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc     60

atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg    120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc    180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc    240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaaggtct acaaactccg    300

atcaccttcg gccaagggac acgactggag attaaacga                           339


<210>  83
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  83

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  84
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  84

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  85
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  85

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  86
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  86

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  87
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  87

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  88
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  88

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  89
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Gln Gly Leu Gln Thr Pro Ile Thr 
1               5                   


<210>  90
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  90

Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
1               5                   10      


<210>  91
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  91
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cgtctggatt caccttcagt aactatggca ttcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatggtttg atggacgtaa taaatactat    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac gcggctgtgt attactgtgc gagagatccc    300

tttgactatg gtgactcctt ctttgactac tggggccagg gcaccctggt caccgtctcc    360

tcagcc                                                               366


<210>  92
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Phe Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Phe Asp Tyr Gly Asp Ser Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120         


<210>  93
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  93

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  94
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  94

Gly Phe Thr Phe Ser Asn Tyr Gly Ile His 
1               5                   10  


<210>  95
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  95

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  96
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  96

Val Ile Trp Phe Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  97
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  97

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  98
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  98

Asp Pro Phe Asp Tyr Gly Asp Ser Phe Phe Asp Tyr 
1               5                   10          


<210>  99
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  99

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  100
<211>  315
<212>  DNA
<213>  Homo sapiens

<400>  100
ctgactcagt ctccatcctc cctgtctgca tctgtaagag acagagtcac catcacttgc     60

cgggcgagtc aggacattag caattattta gcctggtatc agcagaaacc agggaaagtt    120

cctaatctcc tgatctatgc tgcatccact ttgcaatcag gggtcccatc tcggttcagt    180

ggcagtggat ctgggacaga tttcactctc accatcagca gcctgcagcc tgaagatgtt    240

gcaacttatt actgtcaaaa gtataacagt gccccgctca ctttcggcgg agggaccaag    300

gtggagatca aacga                                                     315


<210>  101
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  101

Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Arg Asp Arg Val 
1               5                   10                  15      


Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Gly Lys Val Pro Asn Leu Leu Ile Tyr Ala Ala 
        35                  40                  45              


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val 
65                  70                  75                  80  


Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Leu Thr Phe Gly 
                85                  90                  95      


Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105 


<210>  102
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  102

Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Arg Asp Arg Val 
1               5                   10                  15      


Thr Ile Thr Cys 
            20  


<210>  103
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  103

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  104
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  104

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Asn Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  105
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  105

Ala Ala Ser Thr Leu Gln 
1               5       


<210>  106
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  106

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  107
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  107

Gln Lys Tyr Asn Ser Ala Pro Leu Thr 
1               5                   


<210>  108
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  108

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  109
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  109
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt gactactaca tgacctggat ccgccaggct    120

ccagggaagg ggctggagtg ggtttcatac attagtatta gtggtagtat cacacactac    180

gcagactcag tgaagggccg attcaccatg tccagggaca acgccaagaa ctcactgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagacgga    300

gcagcagctg gtacggatgc ttttgatatc tggggccacg ggacaaaggt caccgtctct    360

tcagcc                                                               366


<210>  110
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  110

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ile Ser Gly Ser Ile Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Ala Ala Gly Thr Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


His Gly Thr Lys Val Thr Val Ser Ser Ala 
        115                 120         


<210>  111
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  111

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  112
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  112

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Thr 
1               5                   10  


<210>  113
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  113

Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  114
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  114

Tyr Ile Ser Ile Ser Gly Ser Ile Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  115

Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  116
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  116

Asp Gly Ala Ala Ala Gly Thr Asp Ala Phe Asp Ile 
1               5                   10          


<210>  117
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  117

Trp Gly His Gly Thr Lys Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  118
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  118
gagatagtga tgacgcagtc tccagccacc ctatctgtgt ctccagggga cagagccacc     60

ctctcctgca gggccagtca gaatgttagc agcaacttgg cctggtacca gcagaaacct    120

ggccaggctc ccaggctcct catctttggt gcatccacca gggccactgg tatcccagcc    180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctacagtct    240

gaagattttg cagtttatta ctgtcagcag tatcattact ggcccacttt cggccctggg    300

accaaagtgg atatcaaacg a                                              321


<210>  119
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  119

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr His Tyr Trp Pro Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
            100                 105         


<210>  120
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  120

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Asp Arg Ala Thr Leu Ser Cys 
            20              


<210>  121
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  121

Arg Ala Ser Gln Asn Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  122
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  122

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Phe 
1               5                   10                  15  


<210>  123
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  123

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  124
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  124

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  125
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  125

Gln Gln Tyr His Tyr Trp Pro Thr 
1               5               


<210>  126
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  126

Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
1               5                   10      


<210>  127
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  127
cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa ggtctcctgc     60

aaggcttctg gatacacctt caccggcttc tatatgcact gggtgcgaca gacccctgga    120

caagggcttg agtggatggg atggatcaac cctaacagtg gtggcacata ttatgtacag    180

aagtttcagg gcagggtcac catgaccagg gacacgtcca tcagcacagt ctacatggag    240

ctgagcaggt tgagatctga cgacacggcc gtatattact gtgcgagaga tgggtatagc    300

agtggagagg actggttcga cccctggggc cagggaaccc tggtcaccgt ctcctcagcc    360


<210>  128
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  128

Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
1               5                   10                  15      


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Phe Tyr Met 
            20                  25                  30          


His Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
        35                  40                  45              


Ile Asn Pro Asn Ser Gly Gly Thr Tyr Tyr Val Gln Lys Phe Gln Gly 
    50                  55                  60                  


Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr Met Glu 
65                  70                  75                  80  


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Gly Tyr Ser Ser Gly Glu Asp Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  129
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  129

Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
1               5                   10                  15      


Lys Val Ser Cys Lys Ala Ser 
            20              


<210>  130
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  130

Gly Tyr Thr Phe Thr Gly Phe Tyr Met His 
1               5                   10  


<210>  131
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  131

Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  132
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  132

Trp Ile Asn Pro Asn Ser Gly Gly Thr Tyr Tyr Val Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  133
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  133

Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  134
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  134

Asp Gly Tyr Ser Ser Gly Glu Asp Trp Phe Asp Pro 
1               5                   10          


<210>  135
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  135

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
1               5                   10          

<210>  136
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  136
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc     60

atctcctgca agtctagtca gagcctcctg catagtggtg gaaagaccta tttgtattgg    120

tacctgcaga ggccaggcca gcctccacag ctcctgatct atgaagtttc caaccggttc    180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc    240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaagtat acaccttccg    300

ctcactttcg gcggagggac caaggtggag atcaaacga                           339


<210>  137
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  137

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Gly Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ile His Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  138
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  138

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  139
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  139

Lys Ser Ser Gln Ser Leu Leu His Ser Gly Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  140
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  140

Trp Tyr Leu Gln Arg Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  141
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  141

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  142
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  142

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  143
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Gln Ser Ile His Leu Pro Leu Thr 
1               5                   


<210>  144
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  144

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  145
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  145
caggtgcagc tggagcagtc ggggggaggc ctggtcaagc ctggggggtc cctgagattc     60

tcctgtgcag cctctggatt caccttcagt agctatagca tgaactgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcattc attagtagta gtagtagtta catatactac    180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagaggac    300

tgggtgggag ctacctttga ctactggggc cagggaaccc tggtcaccgt ctcctcagcc    360


<210>  146
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  146

Gln Val Gln Leu Glu Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Phe Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Phe Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Trp Val Gly Ala Thr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  147
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  147

Gln Val Gln Leu Glu Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Phe Ser Cys Ala Ala Ser 
            20                  25  


<210>  148
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  148

Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn 
1               5                   10  


<210>  149
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  149

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  150
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  150

Phe Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  151
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  151

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  152
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  152

Glu Asp Trp Val Gly Ala Thr Phe Asp Tyr 
1               5                   10  


<210>  153
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  153

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  154
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  154
gacattcagc tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgtc gggcgagtca gggcattagg aattatttag cctggtatca gcagaaacca    120

gggaaagttc ctaagctcct gatctatgct gcttccgctt tgaaattagg ggtcccatct    180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagatgttg caacttatta ctgtcaaaag tataacagtg ccccgatcac cttcggccaa    300

gggacacgac tggacattaa acga                                           324


<210>  155
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  155

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ala Leu Lys Leu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Asp Ile Lys Arg 
            100                 105             


<210>  156
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  156

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  157
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  157

Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala 
1               5                   10      


<210>  158
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  158

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  159
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  159

Ala Ala Ser Ala Leu Lys Leu 
1               5           


<210>  160
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  160

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  161
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  161

Gln Lys Tyr Asn Ser Ala Pro Ile Thr 
1               5                   


<210>  162
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  162

Phe Gly Gln Gly Thr Arg Leu Asp Ile Lys Arg 
1               5                   10      


<210>  163
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  163
caggtgcagc tggagcagtc gggcccagga ctggtgaagc cttcacagaa cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtggtt atttctggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gaacacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagttg acacgtctaa gaaccagttc    240

tccctgaaac tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagac    300

tattactatg atactagtgg tttttcctac cgttacgact ggtactacgg tatggacgtc    360

tggggccaag ggaccacggt caccgtctcc tcagcc                              396


<210>  164
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  164

Gln Val Gln Leu Glu Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Asn Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Phe Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Tyr Asp Thr Ser Gly Phe Ser Tyr Arg Tyr 
            100                 105                 110         


Asp Trp Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser Ala 
    130         


<210>  165
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  165

Gln Val Gln Leu Glu Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Asn Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  166
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  166

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Phe Trp Ser 
1               5                   10          


<210>  167
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  167

Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  168
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  168

Tyr Ile Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  169
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  169

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  170
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  170

Asp Tyr Tyr Tyr Asp Thr Ser Gly Phe Ser Tyr Arg Tyr Asp Trp Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  171
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  171

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  172
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  172
gacatccagc tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaaatgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacaa cataatactt acccggcgtt cggccaaggg    300

accaaggtgg aaatcaaacg a                                              321


<210>  173
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  173

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Tyr Pro Ala 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  174
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  174

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  175
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  175

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  176
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  176

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  177
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  177

Ala Ala Ser Ser Leu Gln Asn 
1               5           


<210>  178
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  178

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  179
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  179

Leu Gln His Asn Thr Tyr Pro Ala 
1               5               


<210>  180
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  180

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  181
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  181
cagctggtgc agtctggagc agaagtgaaa aagcccgggg agtctctgaa gatctcctgt     60

cagggttctg gatacatctt taccaactac tggatcggct gggtgcgcca gatgcccggg    120

aaaggcctgg agtggatggg ggtcatctat cctgatgact ctgataccag atacagcccg    180

tccttccaag gccaggtcac catctcagcc gacaagtcca tcagcaccgc ctacctgcag    240

tggagcagcc tgaaggcctc ggacaccgcc atatattact gtgcgagaca aaaatggcta    300

caacacccct ttgactactg gggccaggga accctggtca ccgtctcctc agcc          354


<210>  182
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  182

Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu 
1               5                   10                  15      


Lys Ile Ser Cys Gln Gly Ser Gly Tyr Ile Phe Thr Asn Tyr Trp Ile 
            20                  25                  30          


Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Val 
        35                  40                  45              


Ile Tyr Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly 
    50                  55                  60                  


Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
65                  70                  75                  80  


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Gln Lys Trp Leu Gln His Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala 
        115             


<210>  183
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  183

Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu 
1               5                   10                  15      


Lys Ile Ser Cys Gln Gly Ser 
            20              


<210>  184
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  184

Gly Tyr Ile Phe Thr Asn Tyr Trp Ile Gly 
1               5                   10  


<210>  185
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  185

Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  186
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  186

Val Ile Tyr Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  187
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  187

Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  188
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  188

Gln Lys Trp Leu Gln His Pro Phe Asp Tyr 
1               5                   10  


<210>  189
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  189

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  190
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  190
gaaattgtgt tgacgcagtc accaggcacc ctgtctttgt ctccagggga aagagtcacc     60

ctctcatgca gggccagtca gagtgttagc agcagatact tagcctggta ccagcagaaa    120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca    180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcagttta ttactgtcag cagtatggta gctcacctcg gacgttcggc    300

caagggacca aggtggaaat caaacga                                        327


<210>  191
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  191

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  192
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  192

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys 
            20              


<210>  193
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  193

Arg Ala Ser Gln Ser Val Ser Ser Arg Tyr Leu Ala 
1               5                   10          


<210>  194
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  194

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  195
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  195

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  196
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  196

Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            20                  25                  30      


<210>  197
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  197

Gln Gln Tyr Gly Ser Ser Pro Arg Thr 
1               5                   


<210>  198
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  198

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  199
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  199
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat    180

gcacagaagt ttcaggacag ggtcaccatg accagggaca cgtccatcag cacagcctac    240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagatttc    300

tttggttcgg ggagtctcct ctactttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctcagcc                                                            369


<210>  200
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  200

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Phe Phe Gly Ser Gly Ser Leu Leu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120             


<210>  201
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  201

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  202
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  202

Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His 
1               5                   10  


<210>  203
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  203

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  204
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  204

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  205
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  205

Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  206
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  206

Asp Phe Phe Gly Ser Gly Ser Leu Leu Tyr Phe Asp Tyr 
1               5                   10              


<210>  207
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  207

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  208
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  208
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc     60

atctcctgca agtctagtca gagcctcctg catagtggtg gaaagaccta tttgtattgg    120

tacctgcaga ggccaggcca gcctccacag ctcctgatct atgaagtttc caaccggttc    180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc    240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaagtat acaccttccg    300

ctcactttcg gcggagggac caaggtggag atcaaacga                           339


<210>  209
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  209

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Gly Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ile His Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  210
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  210

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  211
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  211

Lys Ser Ser Gln Ser Leu Leu His Ser Gly Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  212
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  212

Trp Tyr Leu Gln Arg Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  213
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  213

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  214
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  214

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  215
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Gln Ser Ile His Leu Pro Leu Thr 
1               5                   


<210>  216
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  216

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  217
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  217
caggtgcagc tggagcagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cgtctggatt caccttcaat aactatggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gaaagatgag    300

gaatactact atgtttcggg gcttgactac tggggccagg gaaccctggt caccgtctcc    360

tcagcc                                                               366


<210>  218
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  218

Gln Val Gln Leu Glu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Glu Tyr Tyr Tyr Val Ser Gly Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120         


<210>  219
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  219

Gln Val Gln Leu Glu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  220
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  220

Gly Phe Thr Phe Asn Asn Tyr Gly Met His 
1               5                   10  


<210>  221
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  221

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  222
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  222

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  223
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  223

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  224
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  224

Asp Glu Glu Tyr Tyr Tyr Val Ser Gly Leu Asp Tyr 
1               5                   10          


<210>  225
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  225

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  226
<211>  315
<212>  DNA
<213>  Homo sapiens

<400>  226
ctgactcagt ctccatcctc cctgtctgca tctgtaagag acagagtcac catcacttgc     60

cgggcgagtc aggacattag caattattta gcctggtatc agcagaaacc agggaaagtt    120

cctaatctcc tgatctatgc tgcatccact ttgcaatcag gggtcccatc tcggttcagt    180

ggcagtggat ctgggacaga tttcactctc accatcagca gcctgcagcc tgaagatgtt    240

gcaacttatt actgtcaaaa gtataacagt gccccgctca ctttcggcgg agggaccaag    300

gtggagatca aacga                                                     315


<210>  227
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  227

Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Arg Asp Arg Val 
1               5                   10                  15      


Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Gly Lys Val Pro Asn Leu Leu Ile Tyr Ala Ala 
        35                  40                  45              


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val 
65                  70                  75                  80  


Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Leu Thr Phe Gly 
                85                  90                  95      


Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105 


<210>  228
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  228

Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Arg Asp Arg Val 
1               5                   10                  15      


Thr Ile Thr Cys 
            20  


<210>  229
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  229

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  230
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  230

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Asn Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  231
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  231

Ala Ala Ser Thr Leu Gln 
1               5       


<210>  232
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  232

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  233
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  233

Gln Lys Tyr Asn Ser Ala Pro Leu Thr 
1               5                   


<210>  234
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  234

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  235
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  235
cagatcacct tgaaggagtc tggtcctacg ctggtgacac ccacacagac cctcacgctg     60

acctgcacct tctctgggtt ctcactcagc actggtggaa tgggtgtggg ctggatccgt    120

cagcccccag gaaaggccct ggactggctt acactcattt attggaatga tgataagcac    180

tacagcccat ctctgaagag caggcttacc atcaccaagg acacctccaa aaaccaggtg    240

gtccttagaa tgaccaacat ggaccctgtg gacacagcca cttattactg tgcacacctg    300

cattacgata ttttgactgg ttttaacttt gactactggg gccagggaac cctggtcacc    360

gtctcctcag cc                                                        372


<210>  236
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  236

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Thr Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Gly 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Asp 
        35                  40                  45              


Trp Leu Thr Leu Ile Tyr Trp Asn Asp Asp Lys His Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Arg Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Leu His Tyr Asp Ile Leu Thr Gly Phe Asn Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 


<210>  237
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  237

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Thr Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser 
            20                  25  


<210>  238
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  238

Gly Phe Ser Leu Ser Thr Gly Gly Met Gly Val Gly 
1               5                   10          



<210>  239
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  239

Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Asp Trp Leu Thr 
1               5                   10                  



<210>  240
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  240

Leu Ile Tyr Trp Asn Asp Asp Lys His Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  241
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  241

Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val Val Leu Arg 
1               5                   10                  15      


Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala His 
            20                  25                  30          


<210>  242
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  242

Leu His Tyr Asp Ile Leu Thr Gly Phe Asn Phe Asp Tyr 
1               5                   10              


<210>  243
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  243

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  244
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  244
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc     60

atctcctgca ggtctagtca gagcctcttg gatagtgatg atggaaacac ctatttggac    120

tggtacctgc agaagccagg gcagtctcca cagctcctga tctatacgct ttcctatcgg    180

gcctctggag tcccagacag gttcagtggc agtgggtcag gcactgattt cacactgaaa    240

atcagcaggg tggaggctga ggatgttgga gtttattact gcatgcaacg tatagagttt    300

ccgctcactt tcggcggagg gaccaaggtg gagatcaaac ga                       342


<210>  245
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  245

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  246
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  246

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  247
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  247

Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu 
1               5                   10                  15      


Asp 
    


<210>  248
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  248

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  249
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  249

Thr Leu Ser Tyr Arg Ala Ser 
1               5           


<210>  250
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  250

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  251
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Gln Arg Ile Glu Phe Pro Leu Thr 
1               5                   


<210>  252
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  252

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  253
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  253
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat    180

gcacagaagt ttcaggacag ggtcaccatg accagggaca cgtccatcag cacagcctac    240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagatttc    300

tttggttcgg ggagtctcct ctactttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctcagcc                                                            369


<210>  254
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  254

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Phe Phe Gly Ser Gly Ser Leu Leu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120             


<210>  255
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  255

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  256
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  256

Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His 
1               5                   10  


<210>  257
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  257

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  258
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  258

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  259
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  259

Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  260
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  260

Asp Phe Phe Gly Ser Gly Ser Leu Leu Tyr Phe Asp Tyr 
1               5                   10              


<210>  261
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  261

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
1               5                   10          


<210>  262
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  262
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc     60

atctcctgca agtctagtca gagcctcctg catagtggtg gaaagaccta tttgtattgg    120

tacctgcaga ggccaggcca gcctccacag ctcctgatct atgaagtttc caaccggttc    180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc    240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaagtat acaccttccg    300

ctcactttcg gcggagggac caaggtggag atcaaacga                           339


<210>  263
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  263

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Gly Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ile His Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  264
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  264

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  265
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  265

Lys Ser Ser Gln Ser Leu Leu His Ser Gly Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  266
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  266

Trp Tyr Leu Gln Arg Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  267
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  267

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  268
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  268

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  269
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  269

Met Gln Ser Ile His Leu Pro Leu Thr 
1               5                   


<210>  270
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  270

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  271
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  271

Lys Arg Phe His Asp Val Leu Gly Asn Glu Arg Pro Ser Ala Tyr Met 
1               5                   10                  15      


Arg Glu His Asn Gln Leu Asn Gly Trp Ser Ser Asp Glu Asn Asp Trp 
            20                  25                  30          


Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg Gly Asp Met Arg Trp Lys 
        35                  40                  45              


Asn Ser Trp Lys Gly Gly Arg Val Gln Ala Val Leu Thr Ser Asp Ser 
    50                  55                  60                  


Pro Ala Leu Val Gly Ser Asn Ile Thr Phe Ala Val Asn Leu Ile Phe 
65                  70                  75                  80  


Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly Asn Ile Val Tyr Glu Lys 
                85                  90                  95      


Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala Asp Pro Tyr Val Tyr Asn 
            100                 105                 110         


Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly Glu Asn Gly Thr Gly Gln 
        115                 120                 125             


Ser His His Asn Val Phe Pro Asp Gly Lys Pro Phe Pro His His Pro 
    130                 135                 140                 


Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val Phe His Thr Leu Gly Gln 
145                 150                 155                 160 


Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val Arg Val Ser Val Asn Thr 
                165                 170                 175     


Ala Asn Val Thr Leu Gly Pro Gln Leu Met Glu Val Thr Val Tyr Arg 
            180                 185                 190         


Arg His Gly Arg Ala Tyr Val Pro Ile Ala Gln Val Lys Asp Val Tyr 
        195                 200                 205             


Val Val Thr Asp Gln Ile Pro Val Phe Val Thr Met Phe Gln Lys Asn 
    210                 215                 220                 


Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu Lys Asp Leu Pro Ile Met 
225                 230                 235                 240 


Phe Asp Val Leu Ile His Asp Pro Ser His Phe Leu Asn Tyr Ser Thr 
                245                 250                 255     


Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn Thr Gly Leu Phe Val Ser 
            260                 265                 270         


Thr Asn His Thr Val Asn His Thr Tyr Val Leu Asn Gly Thr Phe Ser 
        275                 280                 285             


Leu Asn Leu Thr Val Lys Ala Ala Ala Pro Gly Pro Cys Pro Pro Pro 
    290                 295                 300                 


Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr Pro Ser Leu Ala Thr Thr 
305                 310                 315                 320 


Leu Lys Ser Tyr Asp Ser Asn Thr Pro Gly Pro Ala Gly Asp Asn Pro 
                325                 330                 335     


Leu Glu Leu Ser Arg Ile Pro Asp Glu Asn Cys Gln Ile Asn Arg Tyr 
            340                 345                 350         


Gly His Phe Gln Ala Thr Ile Thr Ile Val Glu Gly Ile Leu Glu Val 
        355                 360                 365             


Asn Ile Ile Gln Met Thr Asp Val Leu Met Pro Val Pro Trp Pro Glu 
    370                 375                 380                 


Ser Ser Leu Ile Asp Phe Val Val Thr Cys Gln Gly Ser Ile Pro Thr 
385                 390                 395                 400 


Glu Val Cys Thr Ile Ile Ser Asp Pro Thr Cys Glu Ile Thr Gln Asn 
                405                 410                 415     


Thr Val Cys Ser Pro Val Asp Val Asp Glu Met Cys Leu Leu Thr Val 
            420                 425                 430         


Arg Arg Thr Phe Asn Gly Ser Gly Thr Tyr Cys Val Asn Leu Thr Leu 
        435                 440                 445             


Gly Asp Asp Thr Ser Leu Ala Leu Thr Ser Thr Leu Ile Ser Val Pro 
    450                 455                 460                 


Asp Arg Asp Pro Ala Ser 
465                 470 


<210>  272
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  272

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Phe 
            20                  25                  30          


Asn Tyr Tyr Trp Ser Trp Ile Arg His His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Ser Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Thr Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Tyr Asn Trp Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 





