
                                SEQUENCE LISTING

<110> Fernandez-Salas, Ester
      Jacky, Birgitte
      Garay, Patton
      Aoki, Kei Roger

<120> Botulinum Toxin Screening Assays
  
<130> 17596CIP2-PCT (BOT)

<150> US 60/547,591       
<151> 2004-02-24  

<150> PCT/US2005/006421   
<151> 2005-02-23  

<150> US 10/598,073       
<151> 2006-08-17  

<150> US 12/047,441 
<151> 2008-03-13  

<150> US 12/469,569 
<151> 2009-05-20 

<160> 57

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2427
<212> DNA
<213> Homo sapiens

<400> 1
atgggcgccc ctgcctgcgc cctcgcgctc tgcgtggccg tggccatcgt ggccggcgcc 60
tcctcggagt ccttggggac ggagcagcgc gtcgtggggc gagcggcaga agtcccgggc 120
ccagagcccg gccagcagga gcagttggtc ttcggcagcg gggatgctgt ggagctgagc 180
tgtcccccgc ccgggggtgg tcccatgggg cccactgtct gggtcaagga tggcacaggg 240
ctggtgccct cggagcgtgt cctggtgggg ccccagcggc tgcaggtgct gaatgcctcc 300
cacgaggact ccggggccta cagctgccgg cagcggctca cgcagcgcgt actgtgccac 360
ttcagtgtgc gggtgacaga cgctccatcc tcgggagatg acgaagacgg ggaggacgag 420
gctgaggaca caggtgtgga cacaggggcc ccttactgga cacggcccga gcggatggac 480
aagaagctgc tggccgtgcc ggccgccaac accgtccgct tccgctgccc agccgctggc 540
aaccccactc cctccatctc ctggctgaag aacggcaggg agttccgcgg cgagcaccgc 600
attggaggca tcaagctgcg gcatcagcag tggagcctgg tcatggaaag cgtggtgccc 660
tcggaccgcg gcaactacac ctgcgtcgtg gagaacaagt ttggcagcat ccggcagacg 720
tacacgctgg acgtgctgga gcgctccccg caccggccca tcctgcaggc ggggctgccg 780
gccaaccaga cggcggtgct gggcagcgac gtggagttcc actgcaaggt gtacagtgac 840
gcacagcccc acatccagtg gctcaagcac gtggaggtga acggcagcaa ggtgggcccg 900
gacggcacac cctacgttac cgtgctcaag tcctggatca gtgagagtgt ggaggccgac 960
gtgcgcctcc gcctggccaa tgtgtcggag cgggacgggg gcgagtacct ctgtcgagcc 1020
accaatttca taggcgtggc cgagaaggcc ttttggctga gcgttcacgg gccccgagca 1080
gccgaggagg agctggtgga ggctgacgag gcgggcagtg tgtatgcagg catcctcagc 1140
tacggggtgg gcttcttcct gttcatcctg gtggtggcgg ctgtgacgct ctgccgcctg 1200
cgcagccccc ccaagaaagg cctgggctcc cccaccgtgc acaagatctc ccgcttcccg 1260
ctcaagcgac aggtgtccct ggagtccaac gcgtccatga gctccaacac accactggtg 1320
cgcatcgcaa ggctgtcctc aggggagggc cccacgctgg ccaatgtctc cgagctcgag 1380
ctgcctgccg accccaaatg ggagctgtct cgggcccggc tgaccctggg caagcccctt 1440
ggggagggct gcttcggcca ggtggtcatg gcggaggcca tcggcattga caaggaccgg 1500
gccgccaagc ctgtcaccgt agccgtgaag atgctgaaag acgatgccac tgacaaggac 1560
ctgtcggacc tggtgtctga gatggagatg atgaagatga tcgggaaaca caaaaacatc 1620
atcaacctgc tgggcgcctg cacgcagggc gggcccctgt acgtgctggt ggagtacgcg 1680
gccaagggta acctgcggga gtttctgcgg gcgcggcggc ccccgggcct ggactactcc 1740
ttcgacacct gcaagccgcc cgaggagcag ctcaccttca aggacctggt gtcctgtgcc 1800
taccaggtgg cccggggcat ggagtacttg gcctcccaga agtgcatcca cagggacctg 1860
gctgcccgca atgtgctggt gaccgaggac aacgtgatga agatcgcaga cttcgggctg 1920
gcccgggacg tgcacaacct cgactactac aagaagacaa ccaacggccg gctgcccgtg 1980
aagtggatgg cgcctgaggc cttgtttgac cgagtctaca ctcaccagag tgacgtctgg 2040
tcctttgggg tcctgctctg ggagatcttc acgctggggg gctccccgta ccccggcatc 2100
cctgtggagg agctcttcaa gctgctgaag gagggccacc gcatggacaa gcccgccaac 2160
tgcacacacg acctgtacat gatcatgcgg gagtgctggc atgccgcgcc ctcccagagg 2220
cccaccttca agcagctggt ggaggacctg gaccgtgtcc ttaccgtgac gtccaccgac 2280
gagtacctgg acctgtcggc gcctttcgag cagtactccc cgggtggcca ggacaccccc 2340
agctccagct cctcagggga cgactccgtg tttgcccacg acctgctgcc cccggcccca 2400
cccagcagtg ggggctcgcg gacgtga                                     2427

<210> 2
<211> 808
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile
 1               5                  10                  15      
Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val
            20                  25                  30          
Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln
        35                  40                  45              
Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro
    50                  55                  60                  
Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly
65                  70                  75                  80  
Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val
                85                  90                  95      
Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg
            100                 105                 110         
Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala
        115                 120                 125             
Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr
    130                 135                 140                 
Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp
145                 150                 155                 160 
Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys
                165                 170                 175     
Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly
            180                 185                 190         
Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His
        195                 200                 205             
Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly
    210                 215                 220                 
Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr
225                 230                 235                 240 
Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu
            260                 265                 270         
Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu
        275                 280                 285             
Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro
    290                 295                 300                 
Tyr Val Thr Val Leu Lys Ser Trp Ile Ser Glu Ser Val Glu Ala Asp
305                 310                 315                 320 
Val Arg Leu Arg Leu Ala Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr
                325                 330                 335     
Leu Cys Arg Ala Thr Asn Phe Ile Gly Val Ala Glu Lys Ala Phe Trp
            340                 345                 350         
Leu Ser Val His Gly Pro Arg Ala Ala Glu Glu Glu Leu Val Glu Ala
        355                 360                 365             
Asp Glu Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly
    370                 375                 380                 
Phe Phe Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu
385                 390                 395                 400 
Arg Ser Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile
                405                 410                 415     
Ser Arg Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser
            420                 425                 430         
Met Ser Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly
        435                 440                 445             
Glu Gly Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp
    450                 455                 460                 
Pro Lys Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu
465                 470                 475                 480 
Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile
                485                 490                 495     
Asp Lys Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu
            500                 505                 510         
Lys Asp Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met
        515                 520                 525             
Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu
    530                 535                 540                 
Gly Ala Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala
545                 550                 555                 560 
Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly
                565                 570                 575     
Leu Asp Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr
            580                 585                 590         
Phe Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu
        595                 600                 605             
Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn
    610                 615                 620                 
Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu
625                 630                 635                 640 
Ala Arg Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly
                645                 650                 655     
Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val
            660                 665                 670         
Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu
        675                 680                 685             
Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu
    690                 695                 700                 
Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn
705                 710                 715                 720 
Cys Thr His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala
                725                 730                 735     
Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg
            740                 745                 750         
Val Leu Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro
        755                 760                 765             
Phe Glu Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser
    770                 775                 780                 
Ser Gly Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro
785                 790                 795                 800 
Pro Ser Ser Gly Gly Ser Arg Thr
                805             


<210> 3
<211> 2421
<212> DNA
<213> Homo sapiens

<400> 3
atgggcgccc ctgcctgcgc cctcgcgctc tgcgtggccg tggccatcgt ggccggcgcc 60
tcctcggagt ccttggggac ggagcagcgc gtcgtggggc gagcggcaga agtcccgggc 120
ccagagcccg gccagcagga gcagttggtc ttcggcagcg gggatgctgt ggagctgagc 180
tgtcccccgc ccgggggtgg tcccatgggg cccactgtct gggtcaagga tggcacaggg 240
ctggtgccct cggagcgtgt cctggtgggg ccccagcggc tgcaggtgct gaatgcctcc 300
cacgaggact ccggggccta cagctgccgg cagcggctca cgcagcgcgt actgtgccac 360
ttcagtgtgc gggtgacaga cgctccatcc tcgggagatg acgaagacgg ggaggacgag 420
gctgaggaca caggtgtgga cacaggggcc ccttactgga cacggcccga gcggatggac 480
aagaagctgc tggccgtgcc ggccgccaac accgtccgct tccgctgccc agccgctggc 540
aaccccactc cctccatctc ctggctgaag aacggcaggg agttccgcgg cgagcaccgc 600
attggaggca tcaagctgcg gcatcagcag tggagcctgg tcatggaaag cgtggtgccc 660
tcggaccgcg gcaactacac ctgcgtcgtg gagaacaagt ttggcagcat ccggcagacg 720
tacacgctgg acgtgctgga gcgctccccg caccggccca tcctgcaggc ggggctgccg 780
gccaaccaga cggcggtgct gggcagcgac gtggagttcc actgcaaggt gtacagtgac 840
gcacagcccc acatccagtg gctcaagcac gtggaggtga acggcagcaa ggtgggcccg 900
gacggcacac cctacgttac cgtgctcaag acggcgggcg ctaacaccac cgacaaggag 960
ctagaggttc tctccttgca caacgtcacc tttgaggacg ccggggagta cacctgcctg 1020
gcgggcaatt ctattgggtt ttctcatcac tctgcgtggc tggtggtgct gccagccgag 1080
gaggagctgg tggaggctga cgaggcgggc agtgtgtatg caggcatcct cagctacggg 1140
gtgggcttct tcctgttcat cctggtggtg gcggctgtga cgctctgccg cctgcgcagc 1200
ccccccaaga aaggcctggg ctcccccacc gtgcacaaga tctcccgctt cccgctcaag 1260
cgacaggtgt ccctggagtc caacgcgtcc atgagctcca acacaccact ggtgcgcatc 1320
gcaaggctgt cctcagggga gggccccacg ctggccaatg tctccgagct cgagctgcct 1380
gccgacccca aatgggagct gtctcgggcc cggctgaccc tgggcaagcc ccttggggag 1440
ggctgcttcg gccaggtggt catggcggag gccatcggca ttgacaagga ccgggccgcc 1500
aagcctgtca ccgtagccgt gaagatgctg aaagacgatg ccactgacaa ggacctgtcg 1560
gacctggtgt ctgagatgga gatgatgaag atgatcggga aacacaaaaa catcatcaac 1620
ctgctgggcg cctgcacgca gggcgggccc ctgtacgtgc tggtggagta cgcggccaag 1680
ggtaacctgc gggagtttct gcgggcgcgg cggcccccgg gcctggacta ctccttcgac 1740
acctgcaagc cgcccgagga gcagctcacc ttcaaggacc tggtgtcctg tgcctaccag 1800
gtggcccggg gcatggagta cttggcctcc cagaagtgca tccacaggga cctggctgcc 1860
cgcaatgtgc tggtgaccga ggacaacgtg atgaagatcg cagacttcgg gctggcccgg 1920
gacgtgcaca acctcgacta ctacaagaag acaaccaacg gccggctgcc cgtgaagtgg 1980
atggcgcctg aggccttgtt tgaccgagtc tacactcacc agagtgacgt ctggtccttt 2040
ggggtcctgc tctgggagat cttcacgctg gggggctccc cgtaccccgg catccctgtg 2100
gaggagctct tcaagctgct gaaggagggc caccgcatgg acaagcccgc caactgcaca 2160
cacgacctgt acatgatcat gcgggagtgc tggcatgccg cgccctccca gaggcccacc 2220
ttcaagcagc tggtggagga cctggaccgt gtccttaccg tgacgtccac cgacgagtac 2280
ctggacctgt cggcgccttt cgagcagtac tccccgggtg gccaggacac ccccagctcc 2340
agctcctcag gggacgactc cgtgtttgcc cacgacctgc tgcccccggc cccacccagc 2400
agtgggggct cgcggacgtg a                                           2421

<210> 4
<211> 806
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile
 1               5                  10                  15      
Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val
            20                  25                  30          
Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln
        35                  40                  45              
Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro
    50                  55                  60                  
Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly
65                  70                  75                  80  
Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val
                85                  90                  95      
Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg
            100                 105                 110         
Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala
        115                 120                 125             
Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr
    130                 135                 140                 
Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp
145                 150                 155                 160 
Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys
                165                 170                 175     
Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly
            180                 185                 190         
Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His
        195                 200                 205             
Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly
    210                 215                 220                 
Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr
225                 230                 235                 240 
Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu
            260                 265                 270         
Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu
        275                 280                 285             
Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro
    290                 295                 300                 
Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu
305                 310                 315                 320 
Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu
                325                 330                 335     
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala
            340                 345                 350         
Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu
        355                 360                 365             
Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe
    370                 375                 380                 
Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser
385                 390                 395                 400 
Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg
                405                 410                 415     
Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser
            420                 425                 430         
Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly
        435                 440                 445             
Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys
    450                 455                 460                 
Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu
465                 470                 475                 480 
Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys
                485                 490                 495     
Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp
            500                 505                 510         
Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met
        515                 520                 525             
Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala
    530                 535                 540                 
Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys
545                 550                 555                 560 
Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp
                565                 570                 575     
Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys
            580                 585                 590         
Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu
        595                 600                 605             
Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu
    610                 615                 620                 
Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg
625                 630                 635                 640 
Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu
                645                 650                 655     
Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr
            660                 665                 670         
His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe
        675                 680                 685             
Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe
    690                 695                 700                 
Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr
705                 710                 715                 720 
His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser
                725                 730                 735     
Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu
            740                 745                 750         
Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu
        755                 760                 765             
Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly
    770                 775                 780                 
Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser
785                 790                 795                 800 
Ser Gly Gly Ser Arg Thr
                805     


<210> 5
<211> 2085
<212> DNA
<213> Homo sapiens

<400> 5
atgggcgccc ctgcctgcgc cctcgcgctc tgcgtggccg tggccatcgt ggccggcgcc 60
tcctcggagt ccttggggac ggagcagcgc gtcgtggggc gagcggcaga agtcccgggc 120
ccagagcccg gccagcagga gcagttggtc ttcggcagcg gggatgctgt ggagctgagc 180
tgtcccccgc ccgggggtgg tcccatgggg cccactgtct gggtcaagga tggcacaggg 240
ctggtgccct cggagcgtgt cctggtgggg ccccagcggc tgcaggtgct gaatgcctcc 300
cacgaggact ccggggccta cagctgccgg cagcggctca cgcagcgcgt actgtgccac 360
ttcagtgtgc gggtgacaga cgctccatcc tcgggagatg acgaagacgg ggaggacgag 420
gctgaggaca caggtgtgga cacaggggcc ccttactgga cacggcccga gcggatggac 480
aagaagctgc tggccgtgcc ggccgccaac accgtccgct tccgctgccc agccgctggc 540
aaccccactc cctccatctc ctggctgaag aacggcaggg agttccgcgg cgagcaccgc 600
attggaggca tcaagctgcg gcatcagcag tggagcctgg tcatggaaag cgtggtgccc 660
tcggaccgcg gcaactacac ctgcgtcgtg gagaacaagt ttggcagcat ccggcagacg 720
tacacgctgg acgtgctgga gcgctccccg caccggccca tcctgcaggc ggggctgccg 780
gccaaccaga cggcggtgct gggcagcgac gtggagttcc actgcaaggt gtacagtgac 840
gcacagcccc acatccagtg gctcaagcac gtggaggtga acggcagcaa ggtgggcccg 900
gacggcacac cctacgttac cgtgctcaag gtgtccctgg agtccaacgc gtccatgagc 960
tccaacacac cactggtgcg catcgcaagg ctgtcctcag gggagggccc cacgctggcc 1020
aatgtctccg agctcgagct gcctgccgac cccaaatggg agctgtctcg ggcccggctg 1080
accctgggca agccccttgg ggagggctgc ttcggccagg tggtcatggc ggaggccatc 1140
ggcattgaca aggaccgggc cgccaagcct gtcaccgtag ccgtgaagat gctgaaagac 1200
gatgccactg acaaggacct gtcggacctg gtgtctgaga tggagatgat gaagatgatc 1260
gggaaacaca aaaacatcat caacctgctg ggcgcctgca cgcagggcgg gcccctgtac 1320
gtgctggtgg agtacgcggc caagggtaac ctgcgggagt ttctgcgggc gcggcggccc 1380
ccgggcctgg actactcctt cgacacctgc aagccgcccg aggagcagct caccttcaag 1440
gacctggtgt cctgtgccta ccaggtggcc cggggcatgg agtacttggc ctcccagaag 1500
tgcatccaca gggacctggc tgcccgcaat gtgctggtga ccgaggacaa cgtgatgaag 1560
atcgcagact tcgggctggc ccgggacgtg cacaacctcg actactacaa gaagacaacc 1620
aacggccggc tgcccgtgaa gtggatggcg cctgaggcct tgtttgaccg agtctacact 1680
caccagagtg acgtctggtc ctttggggtc ctgctctggg agatcttcac gctggggggc 1740
tccccgtacc ccggcatccc tgtggaggag ctcttcaagc tgctgaagga gggccaccgc 1800
atggacaagc ccgccaactg cacacacgac ctgtacatga tcatgcggga gtgctggcat 1860
gccgcgccct cccagaggcc caccttcaag cagctggtgg aggacctgga ccgtgtcctt 1920
accgtgacgt ccaccgacga gtacctggac ctgtcggcgc ctttcgagca gtactccccg 1980
ggtggccagg acacccccag ctccagctcc tcaggggacg actccgtgtt tgcccacgac 2040
ctgctgcccc cggccccacc cagcagtggg ggctcgcgga cgtga                 2085

<210> 6
<211> 694
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile
 1               5                  10                  15      
Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val
            20                  25                  30          
Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln
        35                  40                  45              
Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro
    50                  55                  60                  
Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly
65                  70                  75                  80  
Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val
                85                  90                  95      
Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg
            100                 105                 110         
Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala
        115                 120                 125             
Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr
    130                 135                 140                 
Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp
145                 150                 155                 160 
Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys
                165                 170                 175     
Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly
            180                 185                 190         
Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His
        195                 200                 205             
Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly
    210                 215                 220                 
Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr
225                 230                 235                 240 
Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu
            260                 265                 270         
Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu
        275                 280                 285             
Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro
    290                 295                 300                 
Tyr Val Thr Val Leu Lys Val Ser Leu Glu Ser Asn Ala Ser Met Ser
305                 310                 315                 320 
Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly
                325                 330                 335     
Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys
            340                 345                 350         
Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu
        355                 360                 365             
Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys
    370                 375                 380                 
Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp
385                 390                 395                 400 
Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met
                405                 410                 415     
Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala
            420                 425                 430         
Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys
        435                 440                 445             
Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp
    450                 455                 460                 
Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys
465                 470                 475                 480 
Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu
                485                 490                 495     
Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu
            500                 505                 510         
Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg
        515                 520                 525             
Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu
    530                 535                 540                 
Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr
545                 550                 555                 560 
His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe
                565                 570                 575     
Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe
            580                 585                 590         
Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr
        595                 600                 605             
His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser
    610                 615                 620                 
Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu
625                 630                 635                 640 
Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu
                645                 650                 655     
Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly
            660                 665                 670         
Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser
        675                 680                 685             
Ser Gly Gly Ser Arg Thr
    690                 


<210> 7
<211> 2409
<212> DNA
<213> Bos taurus

<400> 7
atgggcgccc cggctcgcgc cctcgcgttt tgcgtggcag tggcggtcat gaccggcgcc 60
gccctcgggt ccccgggcgt ggagccccgc gtcgcgcgga gagcggcaga ggtcccgggc 120
cccgagccca gcccgcagga gcgggccttt ggcagcgggg acaccgtgga gctgagctgc 180
cgcttgccgg cgggggtgcc cacagagccc accgtctggg tgaaggacgg cgtgggcctg 240
gcgccctcgg accgcgtcct ggtggggccg cagcggctac aggtgctcaa cgcctcccac 300
gaggacgccg gagcctacag ctgccgccag cgcctctccc agcggctgct gtgcctcttc 360
agcgtgcgcg tgacagatgc tccgtcctca ggggatgacg agggtgggga cgacgaggcc 420
gaggacacag ctggggcccc ttactggacg cggcctgagc ggatggacaa gaagctgcta 480
gcggtgccgg ccgccaacac ggttcgcttc cgctgcccag ctgctggcaa ccccacgcca 540
tccatcacct ggctgaagaa cggcaaggag ttccggggcg agcaccgcat cgggggaatc 600
aaactgcggc agcagcagtg gagcctggtc atggagagcg tggtgccctc ggaccgcggc 660
aactacacgt gcgtcgtgga gaacaagttc ggcagaatcc agcagaccta caccctggac 720
gtgctggagc gctctccgca ccggcccatc ctacaggccg ggctgcccgc taaccagaca 780
gccgtgctgg gcagcgatgt ggagttccac tgcaaggtct acagcgacgc ccagccccac 840
atccagtggc tcaagcacgt ggaggtgaac ggcagcaagg tggggcccga cggcacgccc 900
tacgtcaccg tgctcaagac ggcgggcgct aacaccaccg acaaggagct agaggttcta 960
tccttgcgca atgtcacctt tgaggacgcg ggggagtaca catgtctggc gggcaattct 1020
atcgggtttt cccatcactc tgcgtggctg gtggtgctgc cagctgagga ggagctggtg 1080
gaagccggtg aggctggcgg tgtgttcgcg ggtgtcctca gctacgggct gggcttcctc 1140
ctcttcatcc tggccgtggc cgccgttacg ctctaccgcc tgaggagccc ccctaagaag 1200
ggcctgggct cgcccgcggt gcacaaggtc tcccgcttcc cgctcaagcg acaggtgtcc 1260
ttggagtcca gctcatccat gagctccaac acaccgctgg tacgcattgc ccggctgtca 1320
tcgggcgagg gccccaccct ggccaacgtc tctgagctcg agctgcccgc cgaccccaag 1380
tgggagctgt cccgggcccg gctgaccctg ggcaagcctc ttggggaggg ctgcttcggc 1440
caggtggtca tggcagaggc cattggcatc gacaaggacc gagctgccaa gcctgtcacg 1500
gtggccgtga agatgctgaa agatgacgcc acggataagg acttatcgga cctggtgtcc 1560
gagatggaga tgatgaagat gatcggaaaa cacaagaaca ttatcaacct gctaggcgcc 1620
tgcacgcagg gcgggcccct gtacgtgctg gtggagtacg cggccaaggg caacctgcgg 1680
gaatacctgc gggcacggcg gcccccgggc actgactact ccttcgacac ctgccggctg 1740
cccgaggagc agctcacctt caaagacctg gtgtcctgcg cctaccaggt ggcgcggggc 1800
atggagtacc tggcctcgca gaagtgcatc cacagggacc tggcggcccg caacgtgctg 1860
gtgactgagg acaacgtgat gaaaatcgcc gacttcggcc tggctcgtga cgtgcacaac 1920
ctcgactact acaaaaagac cacaaacggc cgcctgcccg tgaagtggat ggcacccgag 1980
gccttgtttg accgcgtcta cacccaccaa agtgacgtct ggtccttcgg ggtcctgctc 2040
tgggagatct tcacgctggg gggctcgccg taccccggca tccccgtgga ggagctcttc 2100
aagctgctga aggaaggcca ccgcatggac aagccggcca actgcacgca tgacctgtac 2160
atgatcatgc gcgagtgctg gcacgccgcg ccctcgcaga ggcccacctt caagcagctg 2220
gtggaggacc tggaccgtgt gctcaccgtg acgtccaccg acgagtacct ggacctgtcg 2280
gtgcccttcg agcagtactc gccgggcggc caggacaccc ccagctccgg ctcctcgggg 2340
gacgactccg tgttcgctca cgacctgctg cccccggccc catccggcag cggaggctcg 2400
cggacgtga                                                         2409

<210> 8
<211> 802
<212> PRT
<213> Bos taurus

<400> 8
Met Gly Ala Pro Ala Arg Ala Leu Ala Phe Cys Val Ala Val Ala Val
 1               5                  10                  15      
Met Thr Gly Ala Ala Leu Gly Ser Pro Gly Val Glu Pro Arg Val Ala
            20                  25                  30          
Arg Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Ser Pro Gln Glu Arg
        35                  40                  45              
Ala Phe Gly Ser Gly Asp Thr Val Glu Leu Ser Cys Arg Leu Pro Ala
    50                  55                  60                  
Gly Val Pro Thr Glu Pro Thr Val Trp Val Lys Asp Gly Val Gly Leu
65                  70                  75                  80  
Ala Pro Ser Asp Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu
                85                  90                  95      
Asn Ala Ser His Glu Asp Ala Gly Ala Tyr Ser Cys Arg Gln Arg Leu
            100                 105                 110         
Ser Gln Arg Leu Leu Cys Leu Phe Ser Val Arg Val Thr Asp Ala Pro
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Gly Gly Asp Asp Glu Ala Glu Asp Thr Ala
    130                 135                 140                 
Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu
145                 150                 155                 160 
Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly
                165                 170                 175     
Asn Pro Thr Pro Ser Ile Thr Trp Leu Lys Asn Gly Lys Glu Phe Arg
            180                 185                 190         
Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg Gln Gln Gln Trp Ser
        195                 200                 205             
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys
    210                 215                 220                 
Val Val Glu Asn Lys Phe Gly Arg Ile Gln Gln Thr Tyr Thr Leu Asp
225                 230                 235                 240 
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro
                245                 250                 255     
Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys
            260                 265                 270         
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu
        275                 280                 285             
Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val
    290                 295                 300                 
Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu
305                 310                 315                 320 
Ser Leu Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu
                325                 330                 335     
Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val
            340                 345                 350         
Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Gly Glu Ala Gly Gly Val
        355                 360                 365             
Phe Ala Gly Val Leu Ser Tyr Gly Leu Gly Phe Leu Leu Phe Ile Leu
    370                 375                 380                 
Ala Val Ala Ala Val Thr Leu Tyr Arg Leu Arg Ser Pro Pro Lys Lys
385                 390                 395                 400 
Gly Leu Gly Ser Pro Ala Val His Lys Val Ser Arg Phe Pro Leu Lys
                405                 410                 415     
Arg Gln Val Ser Leu Glu Ser Ser Ser Ser Met Ser Ser Asn Thr Pro
            420                 425                 430         
Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala
        435                 440                 445             
Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser
    450                 455                 460                 
Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly
465                 470                 475                 480 
Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala
                485                 490                 495     
Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp
            500                 505                 510         
Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile
        515                 520                 525             
Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly
    530                 535                 540                 
Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg
545                 550                 555                 560 
Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Thr Asp Tyr Ser Phe Asp
                565                 570                 575     
Thr Cys Arg Leu Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser
            580                 585                 590         
Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys
        595                 600                 605             
Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp
    610                 615                 620                 
Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn
625                 630                 635                 640 
Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp
                645                 650                 655     
Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp
            660                 665                 670         
Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly
        675                 680                 685             
Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys
    690                 695                 700                 
Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr
705                 710                 715                 720 
Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr
                725                 730                 735     
Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr Val Thr Ser
            740                 745                 750         
Thr Asp Glu Tyr Leu Asp Leu Ser Val Pro Phe Glu Gln Tyr Ser Pro
        755                 760                 765             
Gly Gly Gln Asp Thr Pro Ser Ser Gly Ser Ser Gly Asp Asp Ser Val
    770                 775                 780                 
Phe Ala His Asp Leu Leu Pro Pro Ala Pro Ser Gly Ser Gly Gly Ser
785                 790                 795                 800 
Arg Thr
        


<210> 9
<211> 2409
<212> DNA
<213> Mus musculus

<400> 9
atggtagtcc cggcctgcgt gctagtgttc tgcgtggcgg tcgtggctgg agctacttcc 60
gagcctcctg gtccagagca gcgagttgtg cggagagcgg cagaggttcc agggcctgaa 120
cctagccagc aggagcaggt ggccttcggc agtggggaca ccgtggagct gagctgccat 180
cctcctggag gtgcccccac agggcccacg gtctgggcta aggatggtac aggtctggtg 240
gcctcccacc gcatcctggt ggggcctcag aggctgcaag tgctaaatgc ctcccacgaa 300
gatgcagggg tctacagctg ccagcaccgg ctcactcggc gtgtgctgtg ccacttcagt 360
gtgcgtgtaa cagatgctcc atcctcagga gatgacgaag atggggagga cgtggctgaa 420
gacacagggg ctccttattg gactcgcccg gagcgaatgg ataagaaact gctggctgtg 480
ccagccgcaa acactgtccg cttccgctgc ccagctgctg gcaaccctac cccctccatc 540
tcctggctga agaatggcaa agaattccga ggggagcatc gcattggggg catcaagctc 600
cggcaccagc agtggagctt ggtcatggaa agtgtggtac cctccgatcg tggcaactat 660
acctgtgtag ttgagaacaa gtttggcagc atccggcaga catacacact ggatgtgctg 720
gagcgctccc cacaccggcc catcctgcag gctgggctgc cggccaacca gacagccatt 780
ctaggcagtg acgtggagtt ccactgcaag gtgtacagcg atgcacagcc acacatccag 840
tggctgaagc acgtggaagt gaacggcagc aaggtgggcc ctgacggcac gccctacgtc 900
actgtactca agtcctggat cagtgagaat gtggaggcag acgcacgcct ccgcctggcc 960
aatgtgtcgg agcgggacgg gggcgagtac ctctgtcgag ccaccaattt cataggcgtg 1020
gctgagaagg ccttttggct gcgtgttcac gggccccaag cagctgagga ggagctgatg 1080
gaaactgatg aggctggcag cgtgtacgca ggcgtcctca gctacggggt ggtcttcttc 1140
ctcttcatcc tggtggtggc agctgtgata ctctgccgcc tgcgcagtcc cccaaagaag 1200
ggcttgggct cgcccaccgt gcacaaggtc tctcgcttcc cgcttaagcg acaggtgtcc 1260
ttggaatcta actcctctat gaactccaac acaccccttg tccggattgc ccggctgtcc 1320
tcaggagaag gtcctgttct ggccaatgtt tctgaacttg agctgcctgc tgaccccaag 1380
tgggagctat ccaggacccg gctgacactt ggtaagcctc ttggagaagg ctgctttgga 1440
caggtggtca tggcagaagc tattggcatc gacaaggacc gtactgccaa gcctgtcacc 1500
gtggccgtga agatgctgaa agatgatgcg actgacaagg acctgtcgga cctggtatct 1560
gagatggaga tgatgaaaat gattggcaag cacaagaaca tcattaacct gctgggggcg 1620
tgcacacagg gtgggcccct gtatgtgctg gtggagtacg cagccaaggg caatctccgg 1680
gagttccttc gggcgcggcg gcctccaggc atggactact cctttgatgc ctgcaggctg 1740
ccagaggaac agctcacctg caaggatcta gtgtcctgtg cctaccaggt ggcacggggc 1800
atggaatact tggcttctca gaagtgtatt cacagagact tggctgccag aaacgtcctg 1860
gtgaccgagg acaatgtgat gaagattgcg gactttggcc tggctcgaga tgtgcacaac 1920
ctggactact acaagaagac cacaaatggc cggctacctg tgaagtggat ggcaccagag 1980
gccctttttg accgagtcta cacccaccag agtgatgttt ggtcttttgg tgtcctcctc 2040
tgggagatct ttacgctggg gggctcaccg tatcctggca tcccagtgga agagcttttc 2100
aagctgttga aagagggcca ccgcatggac aagccagcca gctgcacaca tgacctgtac 2160
atgatcatgc gggaatgttg gcatgcggtg ccttcacaga ggcccacctt caagcagttg 2220
gtagaggatt tagaccgcat cctcactgtg acatcaaccg acgagtactt ggacctctcc 2280
gtgccgtttg agcagtactc gccaggtggc caggacacgc ctagctccag ctcgtccgga 2340
gatgactcgg tgttcaccca tgacctgcta cccccaggtc cacccagtaa cgggggacct 2400
cggacgtga                                                         2409

<210> 10
<211> 802
<212> PRT
<213> Mus musculus

<400> 10
Met Val Val Pro Ala Cys Val Leu Val Phe Cys Val Ala Val Val Ala
 1               5                  10                  15      
Gly Ala Thr Ser Glu Pro Pro Gly Pro Glu Gln Arg Val Val Arg Arg
            20                  25                  30          
Ala Ala Glu Val Pro Gly Pro Glu Pro Ser Gln Gln Glu Gln Val Ala
        35                  40                  45              
Phe Gly Ser Gly Asp Thr Val Glu Leu Ser Cys His Pro Pro Gly Gly
    50                  55                  60                  
Ala Pro Thr Gly Pro Thr Val Trp Ala Lys Asp Gly Thr Gly Leu Val
65                  70                  75                  80  
Ala Ser His Arg Ile Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn
                85                  90                  95      
Ala Ser His Glu Asp Ala Gly Val Tyr Ser Cys Gln His Arg Leu Thr
            100                 105                 110         
Arg Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser
        115                 120                 125             
Ser Gly Asp Asp Glu Asp Gly Glu Asp Val Ala Glu Asp Thr Gly Ala
    130                 135                 140                 
Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val
145                 150                 155                 160 
Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro
                165                 170                 175     
Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Lys Glu Phe Arg Gly Glu
            180                 185                 190         
His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val
        195                 200                 205             
Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val
    210                 215                 220                 
Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu
225                 230                 235                 240 
Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn
                245                 250                 255     
Gln Thr Ala Ile Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr
            260                 265                 270         
Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn
        275                 280                 285             
Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys
    290                 295                 300                 
Ser Trp Ile Ser Glu Asn Val Glu Ala Asp Ala Arg Leu Arg Leu Ala
305                 310                 315                 320 
Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr Leu Cys Arg Ala Thr Asn
                325                 330                 335     
Phe Ile Gly Val Ala Glu Lys Ala Phe Trp Leu Arg Val His Gly Pro
            340                 345                 350         
Gln Ala Ala Glu Glu Glu Leu Met Glu Thr Asp Glu Ala Gly Ser Val
        355                 360                 365             
Tyr Ala Gly Val Leu Ser Tyr Gly Val Val Phe Phe Leu Phe Ile Leu
    370                 375                 380                 
Val Val Ala Ala Val Ile Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys
385                 390                 395                 400 
Gly Leu Gly Ser Pro Thr Val His Lys Val Ser Arg Phe Pro Leu Lys
                405                 410                 415     
Arg Gln Val Ser Leu Glu Ser Asn Ser Ser Met Asn Ser Asn Thr Pro
            420                 425                 430         
Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Val Leu Ala
        435                 440                 445             
Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser
    450                 455                 460                 
Arg Thr Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly
465                 470                 475                 480 
Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Thr Ala
                485                 490                 495     
Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp
            500                 505                 510         
Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile
        515                 520                 525             
Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly
    530                 535                 540                 
Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg
545                 550                 555                 560 
Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Met Asp Tyr Ser Phe Asp
                565                 570                 575     
Ala Cys Arg Leu Pro Glu Glu Gln Leu Thr Cys Lys Asp Leu Val Ser
            580                 585                 590         
Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys
        595                 600                 605             
Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp
    610                 615                 620                 
Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn
625                 630                 635                 640 
Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp
                645                 650                 655     
Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp
            660                 665                 670         
Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly
        675                 680                 685             
Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys
    690                 695                 700                 
Glu Gly His Arg Met Asp Lys Pro Ala Ser Cys Thr His Asp Leu Tyr
705                 710                 715                 720 
Met Ile Met Arg Glu Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr
                725                 730                 735     
Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Val Thr Ser
            740                 745                 750         
Thr Asp Glu Tyr Leu Asp Leu Ser Val Pro Phe Glu Gln Tyr Ser Pro
        755                 760                 765             
Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val
    770                 775                 780                 
Phe Thr His Asp Leu Leu Pro Pro Gly Pro Pro Ser Asn Gly Gly Pro
785                 790                 795                 800 
Arg Thr
        


<210> 11
<211> 2403
<212> DNA
<213> Mus musculus

<400> 11
atggtagtcc cggcctgcgt gctagtgttc tgcgtggcgg tcgtggctgg agctacttcc 60
gagcctcctg gtccagagca gcgagttgtg cggagagcgg cagaggttcc agggcctgaa 120
cctagccagc aggagcaggt ggccttcggc agtggggaca ccgtggagct gagctgccat 180
cctcctggag gtgcccccac agggcccacg gtctgggcta aggatggtac aggtctggtg 240
gcctcccacc gcatcctggt ggggcctcag aggctgcaag tgctaaatgc ctcccacgaa 300
gatgcagggg tctacagctg ccagcaccgg ctcactcggc gtgtgctgtg ccacttcagt 360
gtgcgtgtaa cagatgctcc atcctcagga gatgacgaag atggggagga cgtggctgaa 420
gacacagggg ctccttattg gactcgcccg gagcgaatgg ataagaaact gctggctgtg 480
ccagccgcaa acactgtccg cttccgctgc ccagctgctg gcaaccctac cccctccatc 540
tcctggctga agaatggcaa agaattccga ggggagcatc gcattggggg catcaagctc 600
cggcaccagc agtggagctt ggtcatggaa agtgtggtac cctccgatcg tggcaactat 660
acctgtgtag ttgagaacaa gtttggcagc atccggcaga catacacact ggatgtgctg 720
gagcgctccc cacaccggcc catcctgcag gctgggctgc cggccaacca gacagccatt 780
ctaggcagtg acgtggagtt ccactgcaag gtgtacagcg atgcacagcc acacatccag 840
tggctgaagc acgtggaagt gaacggcagc aaggtgggcc ctgacggcac gccctacgtc 900
actgtactca agactgcagg cgctaacacc accgacaagg agctagaggt tctgtccttg 960
cacaatgtca cctttgagga cgcgggggag tacacctgcc tggcgggcaa ttctattggg 1020
ttttcccatc actctgcgtg gctggtggtg ctgccagctg aggaggagct gatggaaact 1080
gatgaggctg gcagcgtgta cgcaggcgtc ctcagctacg gggtggtctt cttcctcttc 1140
atcctggtgg tggcagctgt gatactctgc cgcctgcgca gtcccccaaa gaagggcttg 1200
ggctcgccca ccgtgcacaa ggtctctcgc ttcccgctta agcgacaggt gtccttggaa 1260
tctaactcct ctatgaactc caacacaccc cttgtccgga ttgcccggct gtcctcagga 1320
gaaggtcctg ttctggccaa tgtttctgaa cttgagctgc ctgctgaccc caagtgggag 1380
ctatccagga cccggctgac acttggtaag cctcttggag aaggctgctt tggacaggtg 1440
gtcatggcag aagctattgg catcgacaag gaccgtactg ccaagcctgt caccgtggcc 1500
gtgaagatgc tgaaagatga tgcgactgac aaggacctgt cggacctggt atctgagatg 1560
gagatgatga aaatgattgg caagcacaag aacatcatta acctgctggg ggcgtgcaca 1620
cagggtgggc ccctgtatgt gctggtggag tacgcagcca agggcaatct ccgggagttc 1680
cttcgggcgc ggcggcctcc aggcatggac tactcctttg atgcctgcag gctgccagag 1740
gaacagctca cctgcaagga tctagtgtcc tgtgcctacc aggtggcacg gggcatggaa 1800
tacttggctt ctcagaagtg tattcacaga gacttggctg ccagaaacgt cctggtgacc 1860
gaggacaatg tgatgaagat tgcggacttt ggcctggctc gagatgtgca caacctggac 1920
tactacaaga agaccacaaa tggccggcta cctgtgaagt ggatggcacc agaggccctt 1980
tttgaccgag tctacaccca ccagagtgat gtttggtctt ttggtgtcct cctctgggag 2040
atctttacgc tggggggctc accgtatcct ggcatcccag tggaagagct tttcaagctg 2100
ttgaaagagg gccaccgcat ggacaagcca gccagctgca cacatgacct gtacatgatc 2160
atgcgggaat gttggcatgc ggtgccttca cagaggccca ccttcaagca gttggtagag 2220
gatttagacc gcatcctcac tgtgacatca accgacgagt acttggacct ctccgtgccg 2280
tttgagcagt actcgccagg tggccaggac acgcctagct ccagctcgtc cggagatgac 2340
tcggtgttca cccatgacct gctaccccca ggtccaccca gtaacggggg acctcggacg 2400
tga                                                               2403

<210> 12
<211> 800
<212> PRT
<213> Mus musculus

<400> 12
Met Val Val Pro Ala Cys Val Leu Val Phe Cys Val Ala Val Val Ala
 1               5                  10                  15      
Gly Ala Thr Ser Glu Pro Pro Gly Pro Glu Gln Arg Val Val Arg Arg
            20                  25                  30          
Ala Ala Glu Val Pro Gly Pro Glu Pro Ser Gln Gln Glu Gln Val Ala
        35                  40                  45              
Phe Gly Ser Gly Asp Thr Val Glu Leu Ser Cys His Pro Pro Gly Gly
    50                  55                  60                  
Ala Pro Thr Gly Pro Thr Val Trp Ala Lys Asp Gly Thr Gly Leu Val
65                  70                  75                  80  
Ala Ser His Arg Ile Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn
                85                  90                  95      
Ala Ser His Glu Asp Ala Gly Val Tyr Ser Cys Gln His Arg Leu Thr
            100                 105                 110         
Arg Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser
        115                 120                 125             
Ser Gly Asp Asp Glu Asp Gly Glu Asp Val Ala Glu Asp Thr Gly Ala
    130                 135                 140                 
Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val
145                 150                 155                 160 
Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro
                165                 170                 175     
Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Lys Glu Phe Arg Gly Glu
            180                 185                 190         
His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val
        195                 200                 205             
Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val
    210                 215                 220                 
Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu
225                 230                 235                 240 
Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn
                245                 250                 255     
Gln Thr Ala Ile Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr
            260                 265                 270         
Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn
        275                 280                 285             
Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys
    290                 295                 300                 
Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu
305                 310                 315                 320 
His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly
                325                 330                 335     
Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro
            340                 345                 350         
Ala Glu Glu Glu Leu Met Glu Thr Asp Glu Ala Gly Ser Val Tyr Ala
        355                 360                 365             
Gly Val Leu Ser Tyr Gly Val Val Phe Phe Leu Phe Ile Leu Val Val
    370                 375                 380                 
Ala Ala Val Ile Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys Gly Leu
385                 390                 395                 400 
Gly Ser Pro Thr Val His Lys Val Ser Arg Phe Pro Leu Lys Arg Gln
                405                 410                 415     
Val Ser Leu Glu Ser Asn Ser Ser Met Asn Ser Asn Thr Pro Leu Val
            420                 425                 430         
Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Val Leu Ala Asn Val
        435                 440                 445             
Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Thr
    450                 455                 460                 
Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val
465                 470                 475                 480 
Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Thr Ala Lys Pro
                485                 490                 495     
Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp
            500                 505                 510         
Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys
        515                 520                 525             
His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro
    530                 535                 540                 
Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe
545                 550                 555                 560 
Leu Arg Ala Arg Arg Pro Pro Gly Met Asp Tyr Ser Phe Asp Ala Cys
                565                 570                 575     
Arg Leu Pro Glu Glu Gln Leu Thr Cys Lys Asp Leu Val Ser Cys Ala
            580                 585                 590         
Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile
        595                 600                 605             
His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val
    610                 615                 620                 
Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp
625                 630                 635                 640 
Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala
                645                 650                 655     
Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp
            660                 665                 670         
Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro
        675                 680                 685             
Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly
    690                 695                 700                 
His Arg Met Asp Lys Pro Ala Ser Cys Thr His Asp Leu Tyr Met Ile
705                 710                 715                 720 
Met Arg Glu Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys
                725                 730                 735     
Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Val Thr Ser Thr Asp
            740                 745                 750         
Glu Tyr Leu Asp Leu Ser Val Pro Phe Glu Gln Tyr Ser Pro Gly Gly
        755                 760                 765             
Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Thr
    770                 775                 780                 
His Asp Leu Leu Pro Pro Gly Pro Pro Ser Asn Gly Gly Pro Arg Thr
785                 790                 795                 800 


<210> 13
<211> 2349
<212> DNA
<213> Mus musculus

<400> 13
atggtagtcc cggcctgcgt gctagtgttc tgcgtggcgg tcgtggctgg agctacttcc 60
gagcctcctg gtccagagca gcgagttgtg cggagagcgg cagaggttcc agggcctgaa 120
cctagccagc aggagcaggt ggccttcggc agtggggaca ccgtggagct gagctgccat 180
cctcctggag gtgcccccac agggcccacg gtctgggcta aggatggtac aggtctggtg 240
gcctcccacc gcatcctggt ggggcctcag aggctgcaag tgctaaatgc ctcccacgaa 300
gatgcagggg tctacagctg ccagcaccgg ctcactcggc gtgtgctgtg ccacttcagt 360
gtgcgtgtaa caggggctcc ttattggact cgcccggagc gaatggataa gaaactgctg 420
gctgtgccag ccgcaaacac tgtccgcttc cgctgcccag ctgctggcaa ccctaccccc 480
tccatctcct ggctgaagaa tggcaaagaa ttccgagggg agcatcgcat tgggggcatc 540
aagctccggc accagcagtg gagcttggtc atggaaagtg tggtaccctc cgatcgtggc 600
aactatacct gtgtagttga gaacaagttt ggcagcatcc ggcagacata cacactggat 660
gtgctggagc gctccccaca ccggcccatc ctgcaggctg ggctgccggc caaccagaca 720
gccattctag gcagtgacgt ggagttccac tgcaaggtgt acagcgatgc acagccacac 780
atccagtggc tgaagcacgt ggaagtgaac ggcagcaagg tgggccctga cggcacgccc 840
tacgtcactg tactcaagac tgcaggcgct aacaccaccg acaaggagct agaggttctg 900
tccttgcaca atgtcacctt tgaggacgcg ggggagtaca cctgcctggc gggcaattct 960
attgggtttt cccatcactc tgcgtggctg gtggtgctgc cagctgagga ggagctgatg 1020
gaaactgatg aggctggcag cgtgtacgca ggcgtcctca gctacggggt ggtcttcttc 1080
ctcttcatcc tggtggtggc agctgtgata ctctgccgcc tgcgcagtcc cccaaagaag 1140
ggcttgggct cgcccaccgt gcacaaggtc tctcgcttcc cgcttaagcg acaggtgtcc 1200
ttggaatcta actcctctat gaactccaac acaccccttg tccggattgc ccggctgtcc 1260
tcaggagaag gtcctgttct ggccaatgtt tctgaacttg agctgcctgc tgaccccaag 1320
tgggagctat ccaggacccg gctgacactt ggtaagcctc ttggagaagg ctgctttgga 1380
caggtggtca tggcagaagc tattggcatc gacaaggacc gtactgccaa gcctgtcacc 1440
gtggccgtga agatgctgaa agatgatgcg actgacaagg acctgtcgga cctggtatct 1500
gagatggaga tgatgaaaat gattggcaag cacaagaaca tcattaacct gctgggggcg 1560
tgcacacagg gtgggcccct gtatgtgctg gtggagtacg cagccaaggg caatctccgg 1620
gagttccttc gggcgcggcg gcctccaggc atggactact cctttgatgc ctgcaggctg 1680
ccagaggaac agctcacctg caaggatcta gtgtcctgtg cctaccaggt ggcacggggc 1740
atggaatact tggcttctca gaagtgtatt cacagagact tggctgccag aaacgtcctg 1800
gtgaccgagg acaatgtgat gaagattgcg gactttggcc tggctcgaga tgtgcacaac 1860
ctggactact acaagaagac cacaaatggc cggctacctg tgaagtggat ggcaccagag 1920
gccctttttg accgagtcta cacccaccag agtgatgttt ggtcttttgg tgtcctcctc 1980
tgggagatct ttacgctggg gggctcaccg tatcctggca tcccagtgga agagcttttc 2040
aagctgttga aagagggcca ccgcatggac aagccagcca gctgcacaca tgacctgtac 2100
atgatcatgc gggaatgttg gcatgcggtg ccttcacaga ggcccacctt caagcagttg 2160
gtagaggatt tagaccgcat cctcactgtg acatcaaccg acgagtactt ggacctctcc 2220
gtgccgtttg agcagtactc gccaggtggc caggacacgc ctagctccag ctcgtccgga 2280
gatgactcgg tgttcaccca tgacctgcta cccccaggtc cacccagtaa cgggggacct 2340
cggacgtga                                                         2349

<210> 14
<211> 782
<212> PRT
<213> Mus musculus

<400> 14
Met Val Val Pro Ala Cys Val Leu Val Phe Cys Val Ala Val Val Ala
 1               5                  10                  15      
Gly Ala Thr Ser Glu Pro Pro Gly Pro Glu Gln Arg Val Val Arg Arg
            20                  25                  30          
Ala Ala Glu Val Pro Gly Pro Glu Pro Ser Gln Gln Glu Gln Val Ala
        35                  40                  45              
Phe Gly Ser Gly Asp Thr Val Glu Leu Ser Cys His Pro Pro Gly Gly
    50                  55                  60                  
Ala Pro Thr Gly Pro Thr Val Trp Ala Lys Asp Gly Thr Gly Leu Val
65                  70                  75                  80  
Ala Ser His Arg Ile Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn
                85                  90                  95      
Ala Ser His Glu Asp Ala Gly Val Tyr Ser Cys Gln His Arg Leu Thr
            100                 105                 110         
Arg Arg Val Leu Cys His Phe Ser Val Arg Val Thr Gly Ala Pro Tyr
        115                 120                 125             
Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro Ala
    130                 135                 140                 
Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro
145                 150                 155                 160 
Ser Ile Ser Trp Leu Lys Asn Gly Lys Glu Phe Arg Gly Glu His Arg
                165                 170                 175     
Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu
            180                 185                 190         
Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu Asn
        195                 200                 205             
Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu Arg
    210                 215                 220                 
Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln Thr
225                 230                 235                 240 
Ala Ile Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp
                245                 250                 255     
Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser
            260                 265                 270         
Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr Ala
        275                 280                 285             
Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His Asn
    290                 295                 300                 
Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser
305                 310                 315                 320 
Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala Glu
                325                 330                 335     
Glu Glu Leu Met Glu Thr Asp Glu Ala Gly Ser Val Tyr Ala Gly Val
            340                 345                 350         
Leu Ser Tyr Gly Val Val Phe Phe Leu Phe Ile Leu Val Val Ala Ala
        355                 360                 365             
Val Ile Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys Gly Leu Gly Ser
    370                 375                 380                 
Pro Thr Val His Lys Val Ser Arg Phe Pro Leu Lys Arg Gln Val Ser
385                 390                 395                 400 
Leu Glu Ser Asn Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile
                405                 410                 415     
Ala Arg Leu Ser Ser Gly Glu Gly Pro Val Leu Ala Asn Val Ser Glu
            420                 425                 430         
Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Thr Arg Leu
        435                 440                 445             
Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met
    450                 455                 460                 
Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Thr Ala Lys Pro Val Thr
465                 470                 475                 480 
Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp Leu Ser
                485                 490                 495     
Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys
            500                 505                 510         
Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro Leu Tyr
        515                 520                 525             
Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg
    530                 535                 540                 
Ala Arg Arg Pro Pro Gly Met Asp Tyr Ser Phe Asp Ala Cys Arg Leu
545                 550                 555                 560 
Pro Glu Glu Gln Leu Thr Cys Lys Asp Leu Val Ser Cys Ala Tyr Gln
                565                 570                 575     
Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg
            580                 585                 590         
Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys
        595                 600                 605             
Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp Tyr Tyr
    610                 615                 620                 
Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu
625                 630                 635                 640 
Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe
                645                 650                 655     
Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro
            660                 665                 670         
Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg
        675                 680                 685             
Met Asp Lys Pro Ala Ser Cys Thr His Asp Leu Tyr Met Ile Met Arg
    690                 695                 700                 
Glu Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu
705                 710                 715                 720 
Val Glu Asp Leu Asp Arg Ile Leu Thr Val Thr Ser Thr Asp Glu Tyr
                725                 730                 735     
Leu Asp Leu Ser Val Pro Phe Glu Gln Tyr Ser Pro Gly Gly Gln Asp
            740                 745                 750         
Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Thr His Asp
        755                 760                 765             
Leu Leu Pro Pro Gly Pro Pro Ser Asn Gly Gly Pro Arg Thr
    770                 775                 780         


<210> 15
<211> 2409
<212> DNA
<213> Rattus norvegicus

<400> 15
atggtagtcc cggcctgcgt gctagtgttc tgcgtggcgg tcgtggctgg agttacttcc 60
gagcctcccg gtccagagca gcgagttggt cggagagcgg cagaggttcc agggcctgaa 120
cctagccagc aggagcaggt ggccttcggc agtggggaca ctgtggagct gagctgccat 180
ccgcctggag gtgcccccac aggccccact ctctgggcta aggacggtgt ggggctggtg 240
gcctcccacc gtatcctggt ggggcctcag aggcttcaag tgctaaacgc cacccatgag 300
gatgctgggg tctacagctg ccagcagcgg ctaacccggc gtgtgctgtg ccactttagt 360
gtgcgtgtaa cagatgctcc gtcctcagga gatgacgaag atggggagga cgtggctgaa 420
gacacagggg ctccttactg gactcgaccg gagcgtatgg ataagaaact gctggctgtg 480
ccagctgcaa acactgtacg cttccgctgc ccagctgctg gcaaccccac cccctccatc 540
ccctggctga agaacggcaa agaattccga ggggagcacc gcattggggg cattaagctc 600
cggcaccagc agtggagctt ggtcatggaa agtgtggtgc cctctgaccg cggcaattac 660
acctgcgtgg ttgagaacaa gtttggcagc atccggcaga cgtacaccct ggatgtgctg 720
gagcgctccc cacaccggcc catcctgcag gctgggctgc cagccaacca gacagccgtt 780
ctgggcagtg acgtggagtt ccactgcaag gtgtacagcg acgcacagcc acacatccag 840
tggctgaagc acgtggaggt gaatgggagc aaggtgggcc ctgacggcac gccctacgtc 900
actgtactca agtcctggat cagtgagaat gtggaggcag acgcacgcct ccgcctggcc 960
aatgtgtcgg agcgggacgg gggcgagtac ctctgtcgag ccaccaattt cataggcgtg 1020
gccgagaagg ccttttggct tcgtgttcac gggccccaag cagccgagga ggagctgatg 1080
gaagttgacg aggctggcag cgtgtacgcg ggtgtcctca gctacggggt gggcttcttc 1140
ctcttcatcc tggtggtggc ggcagtgacg ctctgccgtc tgcgcagtcc cccaaagaag 1200
ggcctgggct cgcccaccgt gcacaaggtc tctcgcttcc cgcttaagcg acaggtgtcc 1260
ttggagtcta attcctctat gaactccaac acacctctcg tccggattgc ccggctgtcc 1320
tcaggagaag gtcctgtcct ggccaatgtt tctgaacttg agctgcctgc tgaccccaag 1380
tgggagctat ccaggacccg gctgacactc ggtaagcctc ttggagaagg ctgctttgga 1440
caggttgtca tggcagaagc tattggcatc gacaaggacc gcactgccaa gcctgtcacc 1500
gtggccgtga agatgctgaa agatgatgcg actgacaagg acctgtcgga cctggtgtct 1560
gagatggaga tgatgaaaat gattggcaag cacaagaaca tcattaacct gttgggggcc 1620
tgcacccagg gtgggcccct gtatgtgctg gtggagtatg cagccaaggg caacctgcga 1680
gagttcctcc gggcacggcg gcctccaggc atggattact cctttgatgc ctgcaggctg 1740
ccagaggaac agctcacctg caaggatctg gtgtcctgtg cctaccaggt ggcacggggc 1800
atggagtact tggcttccca gaagtgtatt cacagagacc tggctgccag aaacgtgctg 1860
gtgactgagg acaatgtgat gaagattgca gactttggcc tggcccgaga tgtgcacaac 1920
ctggattact acaagaagac cacaaatggc cggctacctg tgaagtggat ggcaccagag 1980
gccctttttg accgagtcta cacccatcag agtgatgtct ggtcctttgg tgtcctcctc 2040
tgggagatct ttacactggg tgggtcacca tatcctggca tcccagtgga agagcttttc 2100
aagctgttga aagagggcca ccgcatggac aagccagcca actgcacaca tgacctgtac 2160
atgatcatgc gggaatgttg gcatgcagtg ccttcacaga ggcccacctt caagcagttg 2220
gtagaggatt tagaccgcat cctcacggtg acatcaactg acgagtactt ggacctctcg 2280
gtgccatttg aacagtactc gccaggtggc caagatactc ctagctccag ctcgtccggg 2340
gacgactctg tgttcaccca tgacctgcta cccccaggcc cacccagcaa tgggggacct 2400
cggacgtga                                                         2409

<210> 16
<211> 802
<212> PRT
<213> Rattus norvegicus

<400> 16
Met Val Val Pro Ala Cys Val Leu Val Phe Cys Val Ala Val Val Ala
 1               5                  10                  15      
Gly Val Thr Ser Glu Pro Pro Gly Pro Glu Gln Arg Val Gly Arg Arg
            20                  25                  30          
Ala Ala Glu Val Pro Gly Pro Glu Pro Ser Gln Gln Glu Gln Val Ala
        35                  40                  45              
Phe Gly Ser Gly Asp Thr Val Glu Leu Ser Cys His Pro Pro Gly Gly
    50                  55                  60                  
Ala Pro Thr Gly Pro Thr Leu Trp Ala Lys Asp Gly Val Gly Leu Val
65                  70                  75                  80  
Ala Ser His Arg Ile Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn
                85                  90                  95      
Ala Thr His Glu Asp Ala Gly Val Tyr Ser Cys Gln Gln Arg Leu Thr
            100                 105                 110         
Arg Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser
        115                 120                 125             
Ser Gly Asp Asp Glu Asp Gly Glu Asp Val Ala Glu Asp Thr Gly Ala
    130                 135                 140                 
Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val
145                 150                 155                 160 
Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro
                165                 170                 175     
Thr Pro Ser Ile Pro Trp Leu Lys Asn Gly Lys Glu Phe Arg Gly Glu
            180                 185                 190         
His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val
        195                 200                 205             
Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val
    210                 215                 220                 
Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu
225                 230                 235                 240 
Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn
                245                 250                 255     
Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr
            260                 265                 270         
Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn
        275                 280                 285             
Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys
    290                 295                 300                 
Ser Trp Ile Ser Glu Asn Val Glu Ala Asp Ala Arg Leu Arg Leu Ala
305                 310                 315                 320 
Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr Leu Cys Arg Ala Thr Asn
                325                 330                 335     
Phe Ile Gly Val Ala Glu Lys Ala Phe Trp Leu Arg Val His Gly Pro
            340                 345                 350         
Gln Ala Ala Glu Glu Glu Leu Met Glu Val Asp Glu Ala Gly Ser Val
        355                 360                 365             
Tyr Ala Gly Val Leu Ser Tyr Gly Val Gly Phe Phe Leu Phe Ile Leu
    370                 375                 380                 
Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys
385                 390                 395                 400 
Gly Leu Gly Ser Pro Thr Val His Lys Val Ser Arg Phe Pro Leu Lys
                405                 410                 415     
Arg Gln Val Ser Leu Glu Ser Asn Ser Ser Met Asn Ser Asn Thr Pro
            420                 425                 430         
Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Val Leu Ala
        435                 440                 445             
Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser
    450                 455                 460                 
Arg Thr Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly
465                 470                 475                 480 
Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Thr Ala
                485                 490                 495     
Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp
            500                 505                 510         
Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile
        515                 520                 525             
Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly
    530                 535                 540                 
Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg
545                 550                 555                 560 
Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Met Asp Tyr Ser Phe Asp
                565                 570                 575     
Ala Cys Arg Leu Pro Glu Glu Gln Leu Thr Cys Lys Asp Leu Val Ser
            580                 585                 590         
Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys
        595                 600                 605             
Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp
    610                 615                 620                 
Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn
625                 630                 635                 640 
Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp
                645                 650                 655     
Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp
            660                 665                 670         
Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly
        675                 680                 685             
Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys
    690                 695                 700                 
Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr
705                 710                 715                 720 
Met Ile Met Arg Glu Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr
                725                 730                 735     
Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Val Thr Ser
            740                 745                 750         
Thr Asp Glu Tyr Leu Asp Leu Ser Val Pro Phe Glu Gln Tyr Ser Pro
        755                 760                 765             
Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val
    770                 775                 780                 
Phe Thr His Asp Leu Leu Pro Pro Gly Pro Pro Ser Asn Gly Gly Pro
785                 790                 795                 800 
Arg Thr
        


<210> 17
<211> 2403
<212> DNA
<213> Rattus norvegicus

<400> 17
atggtagtcc cggcctgcgt gctagtgttc tgcgtggcgg tcgtggctgg agttacttcc 60
gagcctcccg gtccagagca gcgagttggt cggagagcgg cagaggttcc agggcctgaa 120
cctagccagc aggagcaggt ggccttcggc agtggggaca ctgtggagct gagctgccat 180
ccgcctggag gtgcccccac aggccccact ctctgggcta aggacggtgt ggggctggtg 240
gcctcccacc gtatcctggt ggggcctcag aggcttcaag tgctaaacgc cacccatgag 300
gatgctgggg tctacagctg ccagcagcgg ctaacccggc gtgtgctgtg ccactttagt 360
gtgcgtgtaa cagatgctcc gtcctcagga gatgacgaag atggggagga cgtggctgaa 420
gacacagggg ctccttactg gactcgaccg gagcgtatgg ataagaaact gctggctgtg 480
ccagctgcaa acactgtacg cttccgctgc ccagctgctg gcaaccccac cccctccatc 540
ccctggctga agaacggcaa agaattccga ggggagcacc gcattggggg cattaagctc 600
cggcaccagc agtggagctt ggtcatggaa agtgtggtgc cctctgaccg cggcaattac 660
acctgcgtgg ttgagaacaa gtttggcagc atccggcaga cgtacaccct ggatgtgctg 720
gagcgctccc cacaccggcc catcctgcag gctgggctgc cagccaacca gacagccgtt 780
ctgggcagtg acgtggagtt ccactgcaag gtgtacagcg acgcacagcc acacatccag 840
tggctgaagc acgtggaggt gaatgggagc aaggtgggcc ctgacggcac gccctacgtc 900
actgtactca agactgcagg agctaacacc accgacaggg agctagaggt tctgtccttg 960
cacaatgtca cctttgagga tgcgggggag tacacctgcc tggcgggcaa ttctatcggg 1020
ttttcccatc actctgcgtg gctggtggtg ctgccagccg aggaggagct gatggaagtt 1080
gacgaggctg gcagcgtgta cgcgggtgtc ctcagctacg gggtgggctt cttcctcttc 1140
atcctggtgg tggcggcagt gacgctctgc cgtctgcgca gtcccccaaa gaagggcctg 1200
ggctcgccca ccgtgcacaa ggtctctcgc ttcccgctta agcgacaggt gtccttggag 1260
tctaattcct ctatgaactc caacacacct ctcgtccgga ttgcccggct gtcctcagga 1320
gaaggtcctg tcctggccaa tgtttctgaa cttgagctgc ctgctgaccc caagtgggag 1380
ctatccagga cccggctgac actcggtaag cctcttggag aaggctgctt tggacaggtt 1440
gtcatggcag aagctattgg catcgacaag gaccgcactg ccaagcctgt caccgtggcc 1500
gtgaagatgc tgaaagatga tgcgactgac aaggacctgt cggacctggt gtctgagatg 1560
gagatgatga aaatgattgg caagcacaag aacatcatta acctgttggg ggcctgcacc 1620
cagggtgggc ccctgtatgt gctggtggag tatgcagcca agggcaacct gcgagagttc 1680
ctccgggcac ggcggcctcc aggcatggat tactcctttg atgcctgcag gctgccagag 1740
gaacagctca cctgcaagga tctggtgtcc tgtgcctacc aggtggcacg gggcatggag 1800
tacttggctt cccagaagtg tattcacaga gacctggctg ccagaaacgt gctggtgact 1860
gaggacaatg tgatgaagat tgcagacttt ggcctggccc gagatgtgca caacctggat 1920
tactacaaga agaccacaaa tggccggcta cctgtgaagt ggatggcacc agaggccctt 1980
tttgaccgag tctacaccca tcagagtgat gtctggtcct ttggtgtcct cctctgggag 2040
atctttacac tgggtgggtc accatatcct ggcatcccag tggaagagct tttcaagctg 2100
ttgaaagagg gccaccgcat ggacaagcca gccaactgca cacatgacct gtacatgatc 2160
atgcgggaat gttggcatgc agtgccttca cagaggccca ccttcaagca gttggtagag 2220
gatttagacc gcatcctcac ggtgacatca actgacgagt acttggacct ctcggtgcca 2280
tttgaacagt actcgccagg tggccaagat actcctagct ccagctcgtc cggggacgac 2340
tctgtgttca cccatgacct gctaccccca ggcccaccca gcaatggggg acctcggacg 2400
tga                                                               2403

<210> 18
<211> 800
<212> PRT
<213> Rattus norvegicus

<400> 18
Met Val Val Pro Ala Cys Val Leu Val Phe Cys Val Ala Val Val Ala
 1               5                  10                  15      
Gly Val Thr Ser Glu Pro Pro Gly Pro Glu Gln Arg Val Gly Arg Arg
            20                  25                  30          
Ala Ala Glu Val Pro Gly Pro Glu Pro Ser Gln Gln Glu Gln Val Ala
        35                  40                  45              
Phe Gly Ser Gly Asp Thr Val Glu Leu Ser Cys His Pro Pro Gly Gly
    50                  55                  60                  
Ala Pro Thr Gly Pro Thr Leu Trp Ala Lys Asp Gly Val Gly Leu Val
65                  70                  75                  80  
Ala Ser His Arg Ile Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn
                85                  90                  95      
Ala Thr His Glu Asp Ala Gly Val Tyr Ser Cys Gln Gln Arg Leu Thr
            100                 105                 110         
Arg Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser
        115                 120                 125             
Ser Gly Asp Asp Glu Asp Gly Glu Asp Val Ala Glu Asp Thr Gly Ala
    130                 135                 140                 
Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val
145                 150                 155                 160 
Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro
                165                 170                 175     
Thr Pro Ser Ile Pro Trp Leu Lys Asn Gly Lys Glu Phe Arg Gly Glu
            180                 185                 190         
His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val
        195                 200                 205             
Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val
    210                 215                 220                 
Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu
225                 230                 235                 240 
Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn
                245                 250                 255     
Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr
            260                 265                 270         
Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn
        275                 280                 285             
Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys
    290                 295                 300                 
Thr Ala Gly Ala Asn Thr Thr Asp Arg Glu Leu Glu Val Leu Ser Leu
305                 310                 315                 320 
His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly
                325                 330                 335     
Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro
            340                 345                 350         
Ala Glu Glu Glu Leu Met Glu Val Asp Glu Ala Gly Ser Val Tyr Ala
        355                 360                 365             
Gly Val Leu Ser Tyr Gly Val Gly Phe Phe Leu Phe Ile Leu Val Val
    370                 375                 380                 
Ala Ala Val Thr Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys Gly Leu
385                 390                 395                 400 
Gly Ser Pro Thr Val His Lys Val Ser Arg Phe Pro Leu Lys Arg Gln
                405                 410                 415     
Val Ser Leu Glu Ser Asn Ser Ser Met Asn Ser Asn Thr Pro Leu Val
            420                 425                 430         
Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Val Leu Ala Asn Val
        435                 440                 445             
Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Thr
    450                 455                 460                 
Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val
465                 470                 475                 480 
Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Thr Ala Lys Pro
                485                 490                 495     
Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp
            500                 505                 510         
Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys
        515                 520                 525             
His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro
    530                 535                 540                 
Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe
545                 550                 555                 560 
Leu Arg Ala Arg Arg Pro Pro Gly Met Asp Tyr Ser Phe Asp Ala Cys
                565                 570                 575     
Arg Leu Pro Glu Glu Gln Leu Thr Cys Lys Asp Leu Val Ser Cys Ala
            580                 585                 590         
Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile
        595                 600                 605             
His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val
    610                 615                 620                 
Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp
625                 630                 635                 640 
Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala
                645                 650                 655     
Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp
            660                 665                 670         
Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro
        675                 680                 685             
Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly
    690                 695                 700                 
His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile
705                 710                 715                 720 
Met Arg Glu Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys
                725                 730                 735     
Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Val Thr Ser Thr Asp
            740                 745                 750         
Glu Tyr Leu Asp Leu Ser Val Pro Phe Glu Gln Tyr Ser Pro Gly Gly
        755                 760                 765             
Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Thr
    770                 775                 780                 
His Asp Leu Leu Pro Pro Gly Pro Pro Ser Asn Gly Gly Pro Arg Thr
785                 790                 795                 800 


<210> 19
<211> 2421
<212> DNA
<213> Gallus gallus

<400> 19
atgcgggcgg cctggggctc cgtctggtgc ctgtgcctgg cggcggccgt cggagcgctg 60
ccggcggcgc gccggcgcgg agcggagcgg agcggcgggc aggcggcaga atacttgagg 120
agcgagaccg cctttctgga agagttggtg tttggaagtg gagataccat tgaactttcc 180
tgtaacaccc agagctcttc tgtgtcagtt ttctggttta aagatggtat tgggattgca 240
ccttccaaca gaactcatat tggacaaaaa ctgttgaaga taatcaatgt gtcatatgac 300
gattcggggc tgtacagttg caagccaagg cattccaacg aggtcctggg aaactttaca 360
gtcagagtga cagattcccc ttcgtcaggt gatgatgaag atgatgacga tgagtcagag 420
gatacaggtg tccccttctg gacccggcca gataagatgg agaagaagct gctggcagtt 480
cctgccgcca acaccgttcg cttccgatgt ccagcaggtg gaaacccaac tcccaccatt 540
tactggctga agaatggcaa agaattcaag ggagagcaca ggatcggggg catcaagttg 600
cgacaccagc agtggagctt ggtgatggag agcgttgtgc cgtcagatcg aggaaactac 660
acctgtgttg tggagaacaa atatggcaat attaggcaca cataccagct tgatgtttta 720
gaacggtcac cccaccgacc aatcctgcaa gcaggactcc ctgccaatca gactgtggtg 780
gtcgggagca atgtggaatt tcactgcaag gtctacagcg atgcccagcc tcatatccag 840
tggctgaaac acgtagaagt caacggcagc aagtatggac ctgatgggac accctatgtc 900
acagtgctga agacggcagg tgttaacaca acggataagg agctagagat tctgtacttg 960
cgaaatgtta cttttgagga tgctggggaa tatacttgtc tcgcagggaa ttctattggg 1020
ttctcacatc actctgcttg gctgacggtg ctaccagcag aggagctgat ggaaatggat 1080
gattcgggct cagtgtacgc tggcattctc agctatggca ctggcttagt cctcttcatc 1140
ctggtgctgg tcattgtgat tatctgcagg atgaaaatgc caaacaaaaa ggccatgaac 1200
accaccactg tacagaaagt ctccaaattt ccactcaaga gacagcaggt gtcgttggag 1260
tccaactctt ccatgaattc caacacaccc ctggtccgga tcactcgtct ctcctccagc 1320
gatgggccga tgctggccaa cgtctctgag ctggaacttc ctccagatcc caagtgggaa 1380
ttggcacgtt ctcgcctgac cctggggaag ccgcttggtg agggctgttt tggccaagtg 1440
gtgatggcgg aagcaattgg gattgataaa gacaagccaa acaaggccat caccgtggct 1500
gtcaagatgt taaaagatga tgccacagac aaggaccttt cagacctggt ctctgagatg 1560
gaaatgatga aaatgattgg gaagcacaaa aacatcatta acctgctcgg tgcttgcacg 1620
caggacggac cgctctacgt gttggttgaa tatgcatcga aggggaactt gcgggaatac 1680
ctcagggcac gtcgcccacc tggcatggac tattccttcg acacctgcaa gctgcccgag 1740
gagcagttga catttaaaga cctggtttcc tgcgcctacc aggtggcccg gggcatggag 1800
tacttggcgt cacagaaatg cattcatcgt gacttggcag ccaggaatgt gttagtcact 1860
gaggacaatg tgatgaaaat agctgatttt ggccttgcta gagacgttca caacatcgac 1920
tattacaaga aaaccaccaa tggtcggctg cctgtgaaat ggatggctcc agaagcattg 1980
tttgaccggg tctatactca ccagagcgat gtctggtctt ttggagtgct actatgggag 2040
atcttcactt tgggagggtc tccgtacccg ggaattcctg ttgaagaact cttcaaactc 2100
ttgaaagaag gccatcggat ggataaaccc gccaactgta cccacgacct gtacatgatc 2160
atgcgggagt gctggcacgc tgtcccctcg cagcgaccca cattcaagca gctggtggaa 2220
gacctggaca gagtcctcac catgacatcc actgatgagt acctggacct ctcggtgccc 2280
tttgagcaat actcacccgc tggccaggac acccacagca cctgctcctc aggggacgac 2340
tcggtttttg cacatgacct gctgcctgat gagccctgcc tgcccaagca cgtgccctgt 2400
aatggcgtca tccgcacgtg a                                           2421

<210> 20
<211> 806
<212> PRT
<213> Gallus gallus

<400> 20
Met Arg Ala Ala Trp Gly Ser Val Trp Cys Leu Cys Leu Ala Ala Ala
 1               5                  10                  15      
Val Gly Ala Leu Pro Ala Ala Arg Arg Arg Gly Ala Glu Arg Ser Gly
            20                  25                  30          
Gly Gln Ala Ala Glu Tyr Leu Arg Ser Glu Thr Ala Phe Leu Glu Glu
        35                  40                  45              
Leu Val Phe Gly Ser Gly Asp Thr Ile Glu Leu Ser Cys Asn Thr Gln
    50                  55                  60                  
Ser Ser Ser Val Ser Val Phe Trp Phe Lys Asp Gly Ile Gly Ile Ala
65                  70                  75                  80  
Pro Ser Asn Arg Thr His Ile Gly Gln Lys Leu Leu Lys Ile Ile Asn
                85                  90                  95      
Val Ser Tyr Asp Asp Ser Gly Leu Tyr Ser Cys Lys Pro Arg His Ser
            100                 105                 110         
Asn Glu Val Leu Gly Asn Phe Thr Val Arg Val Thr Asp Ser Pro Ser
        115                 120                 125             
Ser Gly Asp Asp Glu Asp Asp Asp Asp Glu Ser Glu Asp Thr Gly Val
    130                 135                 140                 
Pro Phe Trp Thr Arg Pro Asp Lys Met Glu Lys Lys Leu Leu Ala Val
145                 150                 155                 160 
Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Gly Gly Asn Pro
                165                 170                 175     
Thr Pro Thr Ile Tyr Trp Leu Lys Asn Gly Lys Glu Phe Lys Gly Glu
            180                 185                 190         
His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val
        195                 200                 205             
Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val
    210                 215                 220                 
Glu Asn Lys Tyr Gly Asn Ile Arg His Thr Tyr Gln Leu Asp Val Leu
225                 230                 235                 240 
Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn
                245                 250                 255     
Gln Thr Val Val Val Gly Ser Asn Val Glu Phe His Cys Lys Val Tyr
            260                 265                 270         
Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn
        275                 280                 285             
Gly Ser Lys Tyr Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys
    290                 295                 300                 
Thr Ala Gly Val Asn Thr Thr Asp Lys Glu Leu Glu Ile Leu Tyr Leu
305                 310                 315                 320 
Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly
                325                 330                 335     
Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Thr Val Leu Pro
            340                 345                 350         
Ala Glu Glu Leu Met Glu Met Asp Asp Ser Gly Ser Val Tyr Ala Gly
        355                 360                 365             
Ile Leu Ser Tyr Gly Thr Gly Leu Val Leu Phe Ile Leu Val Leu Val
    370                 375                 380                 
Ile Val Ile Ile Cys Arg Met Lys Met Pro Asn Lys Lys Ala Met Asn
385                 390                 395                 400 
Thr Thr Thr Val Gln Lys Val Ser Lys Phe Pro Leu Lys Arg Gln Gln
                405                 410                 415     
Val Ser Leu Glu Ser Asn Ser Ser Met Asn Ser Asn Thr Pro Leu Val
            420                 425                 430         
Arg Ile Thr Arg Leu Ser Ser Ser Asp Gly Pro Met Leu Ala Asn Val
        435                 440                 445             
Ser Glu Leu Glu Leu Pro Pro Asp Pro Lys Trp Glu Leu Ala Arg Ser
    450                 455                 460                 
Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val
465                 470                 475                 480 
Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Lys Pro Asn Lys Ala
                485                 490                 495     
Ile Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp
            500                 505                 510         
Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys
        515                 520                 525             
His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro
    530                 535                 540                 
Leu Tyr Val Leu Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr
545                 550                 555                 560 
Leu Arg Ala Arg Arg Pro Pro Gly Met Asp Tyr Ser Phe Asp Thr Cys
                565                 570                 575     
Lys Leu Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser Cys Ala
            580                 585                 590         
Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile
        595                 600                 605             
His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val
    610                 615                 620                 
Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Ile Asp
625                 630                 635                 640 
Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala
                645                 650                 655     
Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp
            660                 665                 670         
Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro
        675                 680                 685             
Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly
    690                 695                 700                 
His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile
705                 710                 715                 720 
Met Arg Glu Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys
                725                 730                 735     
Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr Met Thr Ser Thr Asp
            740                 745                 750         
Glu Tyr Leu Asp Leu Ser Val Pro Phe Glu Gln Tyr Ser Pro Ala Gly
        755                 760                 765             
Gln Asp Thr His Ser Thr Cys Ser Ser Gly Asp Asp Ser Val Phe Ala
    770                 775                 780                 
His Asp Leu Leu Pro Asp Glu Pro Cys Leu Pro Lys His Val Pro Cys
785                 790                 795                 800 
Asn Gly Val Ile Arg Thr
                805     


<210> 21
<211> 2484
<212> DNA
<213> Xenopus laevis

<400> 21
atgtctaagg ctggaggggg ctgtggaatt gccctttatc aagggatcca tatgggaatt 60
gtcaccctgt tctgcactct ctgctttttt ctggtctctg tgaactgtgt cccggctgcc 120
cgactgccag ttacgctccc tggagaggac agagcaaaca gaaaagcatc agattatctc 180
acggtagaac agcccccatt cgatgagctc atgtttacaa ttggagaaac cattgagttg 240
tcctgctctg cggatgatgc atccacgacc accaagtggt tcaaggatgg tatcggcatt 300
gtgccgaaca acagaacaag tacgaggcag ggcctgctga agattatcaa catctcatac 360
gatgactctg ggatatacag ttgcagacta tggcattcta ctgaaattct gcgcaatttt 420
accatcagag taacagactt accatcgtcc ggtgatgatg aggatgacga tgatgaaacc 480
gaagacagag agcctcctcg ctggacccaa cctgagaaga tggagaagaa acttattgca 540
gtccctgccg ctaacacaat ccgattccgg tgcccagccg cggggaatcc cacccctacc 600
atccattggc ttaagaacgg aaaggaattc aggggagagc atcgtattgg tggcatcaaa 660
ctccgacatc agcagtggag cctcgttatg gagagcgtag ttccatcgga taaaggcaac 720
tacacgtgtg tagtggagaa caaatatgga agcatccgtc aaacctatca acttgatgtc 780
ctggagaggt cctctcaccg gcccatcctt caggccgggt tacccgccaa ccagacggtg 840
gtgtttggga gcgacgtgga attccactgc aaagtctaca gtgacgcaca gccacatatt 900
cagtggctta aacacgtgga agtgaatggc agcaagtacg gcccagacgg agatccttac 960
gtcacagtgc tgcaatcttt caccaatggc actgaagtcg attctacctt aagtctaaaa 1020
aatgtgaccg agacccatga aggacagtat gtgtgtagag ccaacaattt cataggagta 1080
gccgaggcat ccttttggct ccacatttac aaaccagcac cagcagaacc agtggagaag 1140
ccagcaacca catcttccag ctccatcacc gttcttattg tggtcacctc gactattgtg 1200
ttcatactgt tggttatcat tgtcatcacc taccgcatga aggtcccttc taagaaggca 1260
atgagcaccc cgccggtgca taaagtctcc aagttcccgc tcaagcggca ggtgtctcta 1320
gagtccaact cttctatgaa ttccaacacc ccgctggtga ggatcactca cctgtcctcc 1380
agcgacggaa ccatgttggc taatgtgtcg gagctcggcc tgcccctgga tcccaagtgg 1440
gagttattga gatcaaggct gactttagga aagccccttg gagaaggctg ctttggtcaa 1500
gtagtgatgg cagaagcaat tggcattgat aaggaaaggc caaataagcc tgttactgta 1560
gctgtaaaga tgcttaaaga tgatgctaca gataaagatc tctccgatct ggtctcggag 1620
atggagatga tgaaaatgat tgggaagcac aaaaatatca tcaatctgct aggagcatgc 1680
actcaggatg gaccactgta cgttcttgtg gaatatgcat ccaaagggaa cctcagggag 1740
tatttaaagg cacggcgccc cccaggaatg gattattctt ttgacacctg caaaattcca 1800
gctgagcagc tgacgttcaa ggacctcgtt tcttgcgcct accaggtagc tcgtggcatg 1860
gagtacctgg cgtcgcaaaa atgtattcac agagatctgg cagccagaaa tgtgttagta 1920
acagatgaca ttgtaatgaa gattgcagat ttcggcttgg ccagggacat ccacaacata 1980
gattattaca agaaaacaac aaatggtcgg ctgccagtca aatggatggc tccggaagct 2040
ttgttcgacc gtatctacac tcatcagagc gatgtatggt cgtacggagt gctgctgtgg 2100
gagatattta cactgggggg ctcgccctac ccagggatcc cagtagagga actctttaag 2160
ctattgaaag aaggccacag aatggacaag ccagcaaact gcacacatga actgtatatg 2220
atcatgagag agtgctggca cgctgtccca tcgcaaagac caaccttcaa gcagctggtt 2280
gaagaccttg accgcgttct tactgtaaca tctactgatg agtacctgga cctgtcggta 2340
ccattcgagc agtattcccc ggcgggccaa gacagtaaca gcacctgctc ctcgggggac 2400
gactcagtct ttgctcatga cattttaccc gatgaaccgt gtcttcccaa acaacagcag 2460
tacaacggcg ccatccgaac atga                                        2484

<210> 22
<211> 827
<212> PRT
<213> Xenopus laevis

<400> 22
Met Ser Lys Ala Gly Gly Gly Cys Gly Ile Ala Leu Tyr Gln Gly Ile
 1               5                  10                  15      
His Met Gly Ile Val Thr Leu Phe Cys Thr Leu Cys Phe Phe Leu Val
            20                  25                  30          
Ser Val Asn Cys Val Pro Ala Ala Arg Leu Pro Val Thr Leu Pro Gly
        35                  40                  45              
Glu Asp Arg Ala Asn Arg Lys Ala Ser Asp Tyr Leu Thr Val Glu Gln
    50                  55                  60                  
Pro Pro Phe Asp Glu Leu Met Phe Thr Ile Gly Glu Thr Ile Glu Leu
65                  70                  75                  80  
Ser Cys Ser Ala Asp Asp Ala Ser Thr Thr Thr Lys Trp Phe Lys Asp
                85                  90                  95      
Gly Ile Gly Ile Val Pro Asn Asn Arg Thr Ser Thr Arg Gln Gly Leu
            100                 105                 110         
Leu Lys Ile Ile Asn Ile Ser Tyr Asp Asp Ser Gly Ile Tyr Ser Cys
        115                 120                 125             
Arg Leu Trp His Ser Thr Glu Ile Leu Arg Asn Phe Thr Ile Arg Val
    130                 135                 140                 
Thr Asp Leu Pro Ser Ser Gly Asp Asp Glu Asp Asp Asp Asp Glu Thr
145                 150                 155                 160 
Glu Asp Arg Glu Pro Pro Arg Trp Thr Gln Pro Glu Lys Met Glu Lys
                165                 170                 175     
Lys Leu Ile Ala Val Pro Ala Ala Asn Thr Ile Arg Phe Arg Cys Pro
            180                 185                 190         
Ala Ala Gly Asn Pro Thr Pro Thr Ile His Trp Leu Lys Asn Gly Lys
        195                 200                 205             
Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln
    210                 215                 220                 
Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn
225                 230                 235                 240 
Tyr Thr Cys Val Val Glu Asn Lys Tyr Gly Ser Ile Arg Gln Thr Tyr
                245                 250                 255     
Gln Leu Asp Val Leu Glu Arg Ser Ser His Arg Pro Ile Leu Gln Ala
            260                 265                 270         
Gly Leu Pro Ala Asn Gln Thr Val Val Phe Gly Ser Asp Val Glu Phe
        275                 280                 285             
His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys
    290                 295                 300                 
His Val Glu Val Asn Gly Ser Lys Tyr Gly Pro Asp Gly Asp Pro Tyr
305                 310                 315                 320 
Val Thr Val Leu Gln Ser Phe Thr Asn Gly Thr Glu Val Asp Ser Thr
                325                 330                 335     
Leu Ser Leu Lys Asn Val Thr Glu Thr His Glu Gly Gln Tyr Val Cys
            340                 345                 350         
Arg Ala Asn Asn Phe Ile Gly Val Ala Glu Ala Ser Phe Trp Leu His
        355                 360                 365             
Ile Tyr Lys Pro Ala Pro Ala Glu Pro Val Glu Lys Pro Ala Thr Thr
    370                 375                 380                 
Ser Ser Ser Ser Ile Thr Val Leu Ile Val Val Thr Ser Thr Ile Val
385                 390                 395                 400 
Phe Ile Leu Leu Val Ile Ile Val Ile Thr Tyr Arg Met Lys Val Pro
                405                 410                 415     
Ser Lys Lys Ala Met Ser Thr Pro Pro Val His Lys Val Ser Lys Phe
            420                 425                 430         
Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ser Ser Met Asn Ser
        435                 440                 445             
Asn Thr Pro Leu Val Arg Ile Thr His Leu Ser Ser Ser Asp Gly Thr
    450                 455                 460                 
Met Leu Ala Asn Val Ser Glu Leu Gly Leu Pro Leu Asp Pro Lys Trp
465                 470                 475                 480 
Glu Leu Leu Arg Ser Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly
                485                 490                 495     
Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys Glu
            500                 505                 510         
Arg Pro Asn Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp Asp
        515                 520                 525             
Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met
    530                 535                 540                 
Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys
545                 550                 555                 560 
Thr Gln Asp Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ser Lys Gly
                565                 570                 575     
Asn Leu Arg Glu Tyr Leu Lys Ala Arg Arg Pro Pro Gly Met Asp Tyr
            580                 585                 590         
Ser Phe Asp Thr Cys Lys Ile Pro Ala Glu Gln Leu Thr Phe Lys Asp
        595                 600                 605             
Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala
    610                 615                 620                 
Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val
625                 630                 635                 640 
Thr Asp Asp Ile Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp
                645                 650                 655     
Ile His Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro
            660                 665                 670         
Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His
        675                 680                 685             
Gln Ser Asp Val Trp Ser Tyr Gly Val Leu Leu Trp Glu Ile Phe Thr
    690                 695                 700                 
Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys
705                 710                 715                 720 
Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr His
                725                 730                 735     
Glu Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Val Pro Ser Gln
            740                 745                 750         
Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr
        755                 760                 765             
Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Val Pro Phe Glu Gln
    770                 775                 780                 
Tyr Ser Pro Ala Gly Gln Asp Ser Asn Ser Thr Cys Ser Ser Gly Asp
785                 790                 795                 800 
Asp Ser Val Phe Ala His Asp Ile Leu Pro Asp Glu Pro Cys Leu Pro
                805                 810                 815     
Lys Gln Gln Gln Tyr Asn Gly Ala Ile Arg Thr
            820                 825         


<210> 23
<211> 2409
<212> DNA
<213> Xenopus laevis

<400> 23
atggtctctg tgaatggtgt cccggctgcc cgactgccag ttacgctccc tggagaggac 60
agagcgagca gaaaagcacc agattatctc atggtagaac agcccccatt cgatgaactc 120
atgtatacaa ttggagaaac cattgagttg tcctgcgctg cagaagatgc ttccacaact 180
accaagtggt gtaaggatgg tattggcatt gtaccgaaca acagaacaag cacaaggcag 240
ggcctgctga agattatcaa cgtctcctcc gatgactccg ggatatacag ctgcagacta 300
tggcattcta ccgagattct gcgcaatttt acaatcagag taacagactt gccatcatct 360
ggtgacgatg aggatgatga tgatgatgat gatgatgaaa ccgaagacag agaacctcct 420
cgctggaccc aacctgagag gatggaaaag aaacttattg cagtccctgc tgctaacaca 480
atccgcttcc ggtgcccagc cgcagggaat cccaccccta ccatccactg gctaaagaac 540
ggaaaggagt tcagggggga acatcgtatt ggtggcatca aactccgaca tcaacagtgg 600
agccttgtta tggagagtgt ggtcccatca gataaaggca actacacgtg tgtggtggag 660
aacaaatatg gaagcatccg tcaaacctat caacttgatg tccttgagag gtcctctcac 720
cggcccatcc ttcaggctgg gttacccggc aaccagacgg ttgtgcttgg gagcgacgtg 780
gaattccact gcaaagtcta cagtgacgca caacctcata ttcagtggct taaacacgtg 840
gaagtgaatg gcagcaaata cggcccagac ggagatcctt acgtctcagt gttgcaatct 900
ttcatcaatg gcactgaagt cgattctacc ctaagtctaa aaaatgtgac cgagaccaat 960
gaaggacagt atgtgtgtag agccaacaat ttcataggag tagccgaggc atccttttgg 1020
ctccacattt acaaaccagc accagcagaa ccagtggaga aggcattgac aacatcttcc 1080
agctctatca ccgtccttat tgtggtcacc tcgaccattg tgttcatact gttggttatc 1140
atcgtcatca cccacctcat gaaggtccct tccaagaagt caatgaccgc cccaccggtg 1200
cataaagtct ccaagttccc cctcaaacgg cagcaggtgt ctctagagtc caactcttct 1260
atgaattcca acaccccgtt ggtgaggatc actcatctgt cctccagcga tggaaccatg 1320
ctggctaatg tgtcggaact tggcctgcca cttgacccca agtgggagtt attgagatca 1380
aggctgactt taggaaagcc cctcggggaa ggctgcttcg gtcaggtggt gatggcagaa 1440
gctattggca ttgataagga aaggccaaat aagcctgcta ctgtagctgt aaagatgctt 1500
aaagacgatg ccacagataa agatctctca gatctggtct ctgagatgga gatgatgaaa 1560
atgattggga agcataaaaa tatcatcaat ctgctgggag catgcactca ggatgggccg 1620
ctgtacgttc tggtggaata cgcatcgaaa gggagcctca gggagtattt aaaggcacgg 1680
cgccccccag gaatggatta ttcttttgat gcctgcaaaa ttccagctga gcagctgacg 1740
ttcaaggacc tagtttcttg tgcctaccag gtagctcgtg gcatggagta cctggcatca 1800
caaaaatgca ttcacagaga tctggcagcc agaaatgtgt tagtaacaga tgacaacgta 1860
atgaagattg cagatttcgg cttggccagg gacatccaca acatagatta ttacaagaaa 1920
acaacaaatg gtcggctgcc tgtgaaatgg atggctccgg aagctttgtt tgaccgtatc 1980
tacactcatc acagcgatgt atggtcgtac ggagtgctgc tgtgggagat atttacactg 2040
gggggctcac cctacccagg gatcccggta gaggaacttt ttaagctatt gaaagaaggc 2100
cacagaatgg acaagccagc aaactgcaca catgaactgt atatgatcat gagagagtgc 2160
tggcacgctg tcccctcaca aagacccgcc ttcaagcagc tggttgaaga ccttgaccgc 2220
gttcttactg taacatctac taatgagtac ctagacctct cggtagcatt cgagcagtat 2280
tctccaccca gccaagacag tcacagcacc tgctcctcag gggacgactc agtctttgct 2340
cacgacattt tacccgatga accgtgtctt cccaaacacc agcagcacaa cggcgccatc 2400
cccacatga                                                         2409

<210> 24
<211> 802
<212> PRT
<213> Xenopus laevis

<400> 24
Met Val Ser Val Asn Gly Val Pro Ala Ala Arg Leu Pro Val Thr Leu
 1               5                  10                  15      
Pro Gly Glu Asp Arg Ala Ser Arg Lys Ala Pro Asp Tyr Leu Met Val
            20                  25                  30          
Glu Gln Pro Pro Phe Asp Glu Leu Met Tyr Thr Ile Gly Glu Thr Ile
        35                  40                  45              
Glu Leu Ser Cys Ala Ala Glu Asp Ala Ser Thr Thr Thr Lys Trp Cys
    50                  55                  60                  
Lys Asp Gly Ile Gly Ile Val Pro Asn Asn Arg Thr Ser Thr Arg Gln
65                  70                  75                  80  
Gly Leu Leu Lys Ile Ile Asn Val Ser Ser Asp Asp Ser Gly Ile Tyr
                85                  90                  95      
Ser Cys Arg Leu Trp His Ser Thr Glu Ile Leu Arg Asn Phe Thr Ile
            100                 105                 110         
Arg Val Thr Asp Leu Pro Ser Ser Gly Asp Asp Glu Asp Asp Asp Asp
        115                 120                 125             
Asp Asp Asp Asp Glu Thr Glu Asp Arg Glu Pro Pro Arg Trp Thr Gln
    130                 135                 140                 
Pro Glu Arg Met Glu Lys Lys Leu Ile Ala Val Pro Ala Ala Asn Thr
145                 150                 155                 160 
Ile Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Thr Ile His
                165                 170                 175     
Trp Leu Lys Asn Gly Lys Glu Phe Arg Gly Glu His Arg Ile Gly Gly
            180                 185                 190         
Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu Ser Val Val
        195                 200                 205             
Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Lys Tyr Gly
    210                 215                 220                 
Ser Ile Arg Gln Thr Tyr Gln Leu Asp Val Leu Glu Arg Ser Ser His
225                 230                 235                 240 
Arg Pro Ile Leu Gln Ala Gly Leu Pro Gly Asn Gln Thr Val Val Leu
                245                 250                 255     
Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro
            260                 265                 270         
His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser Lys Tyr Gly
        275                 280                 285             
Pro Asp Gly Asp Pro Tyr Val Ser Val Leu Gln Ser Phe Ile Asn Gly
    290                 295                 300                 
Thr Glu Val Asp Ser Thr Leu Ser Leu Lys Asn Val Thr Glu Thr Asn
305                 310                 315                 320 
Glu Gly Gln Tyr Val Cys Arg Ala Asn Asn Phe Ile Gly Val Ala Glu
                325                 330                 335     
Ala Ser Phe Trp Leu His Ile Tyr Lys Pro Ala Pro Ala Glu Pro Val
            340                 345                 350         
Glu Lys Ala Leu Thr Thr Ser Ser Ser Ser Ile Thr Val Leu Ile Val
        355                 360                 365             
Val Thr Ser Thr Ile Val Phe Ile Leu Leu Val Ile Ile Val Ile Thr
    370                 375                 380                 
His Leu Met Lys Val Pro Ser Lys Lys Ser Met Thr Ala Pro Pro Val
385                 390                 395                 400 
His Lys Val Ser Lys Phe Pro Leu Lys Arg Gln Gln Val Ser Leu Glu
                405                 410                 415     
Ser Asn Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr His
            420                 425                 430         
Leu Ser Ser Ser Asp Gly Thr Met Leu Ala Asn Val Ser Glu Leu Gly
        435                 440                 445             
Leu Pro Leu Asp Pro Lys Trp Glu Leu Leu Arg Ser Arg Leu Thr Leu
    450                 455                 460                 
Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu
465                 470                 475                 480 
Ala Ile Gly Ile Asp Lys Glu Arg Pro Asn Lys Pro Ala Thr Val Ala
                485                 490                 495     
Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu
            500                 505                 510         
Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile
        515                 520                 525             
Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Leu
    530                 535                 540                 
Val Glu Tyr Ala Ser Lys Gly Ser Leu Arg Glu Tyr Leu Lys Ala Arg
545                 550                 555                 560 
Arg Pro Pro Gly Met Asp Tyr Ser Phe Asp Ala Cys Lys Ile Pro Ala
                565                 570                 575     
Glu Gln Leu Thr Phe Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala
            580                 585                 590         
Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu
        595                 600                 605             
Ala Ala Arg Asn Val Leu Val Thr Asp Asp Asn Val Met Lys Ile Ala
    610                 615                 620                 
Asp Phe Gly Leu Ala Arg Asp Ile His Asn Ile Asp Tyr Tyr Lys Lys
625                 630                 635                 640 
Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu
                645                 650                 655     
Phe Asp Arg Ile Tyr Thr His His Ser Asp Val Trp Ser Tyr Gly Val
            660                 665                 670         
Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile
        675                 680                 685             
Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp
    690                 695                 700                 
Lys Pro Ala Asn Cys Thr His Glu Leu Tyr Met Ile Met Arg Glu Cys
705                 710                 715                 720 
Trp His Ala Val Pro Ser Gln Arg Pro Ala Phe Lys Gln Leu Val Glu
                725                 730                 735     
Asp Leu Asp Arg Val Leu Thr Val Thr Ser Thr Asn Glu Tyr Leu Asp
            740                 745                 750         
Leu Ser Val Ala Phe Glu Gln Tyr Ser Pro Pro Ser Gln Asp Ser His
        755                 760                 765             
Ser Thr Cys Ser Ser Gly Asp Asp Ser Val Phe Ala His Asp Ile Leu
    770                 775                 780                 
Pro Asp Glu Pro Cys Leu Pro Lys His Gln Gln His Asn Gly Ala Ile
785                 790                 795                 800 
Pro Thr
        


<210> 25
<211> 2391
<212> DNA
<213> Pleurodeles waltlii

<400> 25
atgctcgtct ggctctgcgg cttgtgtctg gtgactctgg cgggcggacg ttcggcggcc 60
aggctgcccc tcaccgaggg ccgacccaca gcagacttcc tgcccggcga cgcctccctg 120
gtggaagagc tcctgttcgg cacgggggac accatcgagc tctcctgcac caccccgggc 180
tcctctgtgt ccgtggtgtg gttcaaagac gggatctcgg tggacccacc aacctggtcc 240
cacaccggcc agaagctgct gaagatcatc aacgtgtcct acgacgactc gggagtgtac 300
agctgcaagg cccggcagtc cagcgaggtg ctccggaacg tgaccgtcag ggtgaccgat 360
tctccgtcat ccggtgatga cgaagatgat gatgaggaat ctgaaagtgc aaatgcacca 420
aaattcacgc gaccggaatg gatggagaag aaactgcttg cagtgcccgc agccaacacg 480
gtgcgcttcc gatgcccagc tgcaggaaag ccaacgccat ccatcacttg gctgaaaaac 540
ggcaaggagt tcaaaggcga gcatcggatt gggggcataa agctaagaca ccagcagtgg 600
agtttggtga tggagagtgt agtcccatcc gatcggggaa attacacatg tgtggtggca 660
aacaagtacg gcaccatccg agagacctac acattggatg tccttgaacg aactcctcac 720
cggcccatcc tccaggcggg attccgttcc aacaagactg tggtggtagg aagcgatgtg 780
gagttccatt gcaaggtata cagtgatgct cagccgcaca tccagtggct gaaacacgtg 840
gaggttaatg gcagcaagtt tggacctgat gggaacccgt atgtcacagt gcttaagacg 900
gcaggtgtta atacctcgga taaggagcta gaaattcagt tcttgcgaaa tgtaactttt 960
gaggatgctg gggagtatac ttgtctcgct gggaactcta ttggctattc ccatcattct 1020
gcttggctca cggtgctgcc accagcagag ccggtcccag acgtcgacac ctctgtcagc 1080
attcttgccg ctgcaggatg tgtcgcagtt gttatactgg tggtgatcat aatctttact 1140
tacaagatga agatgccctc caagaagacc atgaacaccg ccactgtgca caaagtctca 1200
aagttccctc tcaagagaca ggtgtcactg gagtccaact cttcaatgaa ttccaacacc 1260
cctctggtgc gaatcacccg cctgtcgtcc agcgatggtc cgatgctggc caacgtgtcc 1320
gagctggagc tacccgctga tccgaagtgg gaattgtctc gttcacgctt gactttgggc 1380
aaacctcttg gggaaggatg ctttggccag gtggtgatgg cggatgcagt tggcattgaa 1440
aaggataagc caaacaaggc cacctcggtt gccgttaaga tgttgaaaga tgatgccact 1500
gataaagacc tgtcggatct agtctctgaa atggaaatga tgaaaatgat tgggaagcac 1560
aaaaacatca ttaatctcct gggagcctgc acgcaggatg gcccactcta cgtgctggtg 1620
gaatatgcat ccaaaggaaa cttgcgggag tacctgaggg cccggcgccc tcctggcatg 1680
gattactcct tcgacacctg caaacttccc gaagagcagt tgaccttcaa ggacttggta 1740
tcctgtgcct accaggtggc ccgcggcatg gagtacctgg cctctcagaa gtgcatacac 1800
cgagatctgg cagcccggaa cgtgctggtg acggatgaca acgttatgaa gattgctgat 1860
tttggcctgg cgagagatgt gcacaacatc gactactaca agaaaactac aaatggccga 1920
ctgcccgtga agtggatggc tccggaggct ttgttcgacc gggtctacac tcaccaaagc 1980
gacgtctggt cgtttggagt gcttctgtgg gagatcttca cgctgggggg ctcgccgtac 2040
cctggaatcc cagtggaaga actcttcaag ctgttaaagg aaggccatcg aatggacaaa 2100
ccagcgaact gcacgcatga gctgtacatg atcatgcggg agtgctggca tgcagtgcca 2160
tcccagcggc caaccttcaa gcaactcgta gaagacttgg accgggtcct tacggtgacc 2220
tccactgatg agtacctcga tctctctgtg cccttcgagc agtattcgcc tgcctgccca 2280
gacagccaca gcagctgctc ttctggagac gattcggtct ttgcccacga cctgcccgag 2340
gagccctgcc ttccgaagca ccagcagtac aatggagtaa tccgaacatg a          2391

<210> 26
<211> 796
<212> PRT
<213> Pleurodeles waltlii

<400> 26
Met Leu Val Trp Leu Cys Gly Leu Cys Leu Val Thr Leu Ala Gly Gly
 1               5                  10                  15      
Arg Ser Ala Ala Arg Leu Pro Leu Thr Glu Gly Arg Pro Thr Ala Asp
            20                  25                  30          
Phe Leu Pro Gly Asp Ala Ser Leu Val Glu Glu Leu Leu Phe Gly Thr
        35                  40                  45              
Gly Asp Thr Ile Glu Leu Ser Cys Thr Thr Pro Gly Ser Ser Val Ser
    50                  55                  60                  
Val Val Trp Phe Lys Asp Gly Ile Ser Val Asp Pro Pro Thr Trp Ser
65                  70                  75                  80  
His Thr Gly Gln Lys Leu Leu Lys Ile Ile Asn Val Ser Tyr Asp Asp
                85                  90                  95      
Ser Gly Val Tyr Ser Cys Lys Ala Arg Gln Ser Ser Glu Val Leu Arg
            100                 105                 110         
Asn Val Thr Val Arg Val Thr Asp Ser Pro Ser Ser Gly Asp Asp Glu
        115                 120                 125             
Asp Asp Asp Glu Glu Ser Glu Ser Ala Asn Ala Pro Lys Phe Thr Arg
    130                 135                 140                 
Pro Glu Trp Met Glu Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr
145                 150                 155                 160 
Val Arg Phe Arg Cys Pro Ala Ala Gly Lys Pro Thr Pro Ser Ile Thr
                165                 170                 175     
Trp Leu Lys Asn Gly Lys Glu Phe Lys Gly Glu His Arg Ile Gly Gly
            180                 185                 190         
Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu Ser Val Val
        195                 200                 205             
Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Ala Asn Lys Tyr Gly
    210                 215                 220                 
Thr Ile Arg Glu Thr Tyr Thr Leu Asp Val Leu Glu Arg Thr Pro His
225                 230                 235                 240 
Arg Pro Ile Leu Gln Ala Gly Phe Arg Ser Asn Lys Thr Val Val Val
                245                 250                 255     
Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro
            260                 265                 270         
His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser Lys Phe Gly
        275                 280                 285             
Pro Asp Gly Asn Pro Tyr Val Thr Val Leu Lys Thr Ala Gly Val Asn
    290                 295                 300                 
Thr Ser Asp Lys Glu Leu Glu Ile Gln Phe Leu Arg Asn Val Thr Phe
305                 310                 315                 320 
Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Tyr
                325                 330                 335     
Ser His His Ser Ala Trp Leu Thr Val Leu Pro Pro Ala Glu Pro Val
            340                 345                 350         
Pro Asp Val Asp Thr Ser Val Ser Ile Leu Ala Ala Ala Gly Cys Val
        355                 360                 365             
Ala Val Val Ile Leu Val Val Ile Ile Ile Phe Thr Tyr Lys Met Lys
    370                 375                 380                 
Met Pro Ser Lys Lys Thr Met Asn Thr Ala Thr Val His Lys Val Ser
385                 390                 395                 400 
Lys Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ser Ser Met
                405                 410                 415     
Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Arg Leu Ser Ser Ser Asp
            420                 425                 430         
Gly Pro Met Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro
        435                 440                 445             
Lys Trp Glu Leu Ser Arg Ser Arg Leu Thr Leu Gly Lys Pro Leu Gly
    450                 455                 460                 
Glu Gly Cys Phe Gly Gln Val Val Met Ala Asp Ala Val Gly Ile Glu
465                 470                 475                 480 
Lys Asp Lys Pro Asn Lys Ala Thr Ser Val Ala Val Lys Met Leu Lys
                485                 490                 495     
Asp Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu
            500                 505                 510         
Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly
        515                 520                 525             
Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ser
    530                 535                 540                 
Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met
545                 550                 555                 560 
Asp Tyr Ser Phe Asp Thr Cys Lys Leu Pro Glu Glu Gln Leu Thr Phe
                565                 570                 575     
Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr
            580                 585                 590         
Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val
        595                 600                 605             
Leu Val Thr Asp Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala
    610                 615                 620                 
Arg Asp Val His Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg
625                 630                 635                 640 
Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr
                645                 650                 655     
Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile
            660                 665                 670         
Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu
        675                 680                 685             
Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys
    690                 695                 700                 
Thr His Glu Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Val Pro
705                 710                 715                 720 
Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val
                725                 730                 735     
Leu Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Val Pro Phe
            740                 745                 750         
Glu Gln Tyr Ser Pro Ala Cys Pro Asp Ser His Ser Ser Cys Ser Ser
        755                 760                 765             
Gly Asp Asp Ser Val Phe Ala His Asp Leu Pro Glu Glu Pro Cys Leu
    770                 775                 780                 
Pro Lys His Gln Gln Tyr Asn Gly Val Ile Arg Thr
785                 790                 795     


<210> 27
<211> 2403
<212> DNA
<213> Danio rerio

<400> 27
atggtcccac tctgtctcct cctgtacctc gcaaccctcg tcttcccacc agtgtacagt 60
gcacacctgc tgtccccaga gcccacagac tgggtatcga gtgaggtgga agtgtttctg 120
gaggactatg tggcgggagt cggggataca gtagttctgt cctgcacgcc gcaagacttt 180
ctccttccca tcgtatggca aaaagacgga gacgccgttt cttcaagcaa ccgtacacga 240
gtgggccaga aagccctccg catcatcaat gtctcctatg aagactcggg tgtttactcc 300
tgcagacatg cccacaagag catgcttctg agcaactaca ccgtcaaagt catcgattcg 360
ctgtcctctg gtgatgatga ggactatgat gaagatgagg acgaggcagg taatggaaat 420
gcagaagctc catactggac ccgttcggac cggatggaga agaaactatt ggctgttcct 480
gctgccaata cagtcaagtt ccgctgtcct gctgctggca acccaacgcc cagtatccat 540
tggctgaaaa atggcaagga gttcaaggga gagcagagaa tgggcggcat taagctgagg 600
catcagcagt ggagcttggt catggagagt gccgttccat ccgaccgggg aaattacaca 660
tgtgtggtgc agaacaaata cgggtcaatc aagcacactt atcaactcga tgtgctggag 720
cgctcccctc accggcccat cttacaggca ggactgccag ccaatcagac ggtagtggtg 780
ggcagtgatg tggagttcca ctgtaaggtg tacagtgatg ctcagccaca catccagtgg 840
ctgaaacaca ttgaagtcaa tggaagccaa tatgggccca atggcgcccc ctacgtcaat 900
gttcttaaga ctgctgggat aaatactacg gataaagagc tggagattct ctacctgacc 960
aatgtgtctt tcgaggatgc ggggcaatac acttgtctgg cagggaactc gattggctat 1020
aaccatcact ctgcttggct tacagtctta ccagcggtgg agatggagag agaggatgat 1080
tatgcagaca tcctcatcta tgtgacaagc tgcgtgctct tcattctcac catggtcatc 1140
attattctct gccgaatgtg gataaacacg cagaagactc tcccggcacc acctgttcaa 1200
aaactgtcca aattccccct caagagacag gtgtccttgg aatccaactc ttccatgaat 1260
tcaaacaccc cgctggtcag gatcgcccgc ctgtcatcca gcgatgggcc gatgttgcct 1320
aacgtgtctg aacttgaact gccctctgac cccaagtggg agtttactcg aacaaagtta 1380
acgttgggga aaccgttggg agagggctgc tttgggcagg tggtgatggc tgaagccatt 1440
gggattgaca aagaaaaacc caacaaacct ctaactgttg ctgtcaagat gctcaaagat 1500
gacggcacag ataaagacct gtcagacctt gtgtctgaaa tggagatgat gaagatgatt 1560
gggaaacata agaacatcat taacttgctg ggagcatgta ctcaagacgg tcctctgtac 1620
gtgctggtag aatacgcctc taaagggaat cttagggaat acttacgagc cagaaggcca 1680
cctgggatgg actactcatt cgacacctgt aagatcccga acgaaacgct aacatttaaa 1740
gacctggtgt cctgcgccta tcaggtcgcc aggggtatgg agtacctggc ctcaaagaag 1800
tgtatccata gggaccccgc agcccggaat gttctggtta ccgaggacaa cgtgatgaag 1860
attgcagact tcggccttgc cagagatgtg cacaacattg actactacaa gaagaccacc 1920
aacggtcgtc tgcccgtcaa atggatggca ccagaagcac tgttcgatcg cgtctacacg 1980
caccagagcg atgtgtggtc ttatggtgtg ttgttgtggg agattttcac tcttggtgga 2040
tccccgtatc caggtatccc agtggaggag ctctttaaac tgctgaagga aggccatcgg 2100
atggacaaac cggccaactg cactcatgaa ctgtacatga tcatgcgaga atgttggcat 2160
gctgttcctt cacaaagacc cacgttcaga cagctggtgg aggaccacga cagggttctt 2220
tccatgacct ccactgacga gtacctggac ctctctgtac cgttcgagca gtattcaccg 2280
acctgtccgg actccaacag cacctgttcc tctggcgatg actctgtgtt tgcccacgac 2340
cccttacctg aggagccatg cctccctaaa caccaccaca gcaacggggt catacgaaca 2400
taa                                                               2403

<210> 28
<211> 800
<212> PRT
<213> Danio rerio

<400> 28
Met Val Pro Leu Cys Leu Leu Leu Tyr Leu Ala Thr Leu Val Phe Pro
 1               5                  10                  15      
Pro Val Tyr Ser Ala His Leu Leu Ser Pro Glu Pro Thr Asp Trp Val
            20                  25                  30          
Ser Ser Glu Val Glu Val Phe Leu Glu Asp Tyr Val Ala Gly Val Gly
        35                  40                  45              
Asp Thr Val Val Leu Ser Cys Thr Pro Gln Asp Phe Leu Leu Pro Ile
    50                  55                  60                  
Val Trp Gln Lys Asp Gly Asp Ala Val Ser Ser Ser Asn Arg Thr Arg
65                  70                  75                  80  
Val Gly Gln Lys Ala Leu Arg Ile Ile Asn Val Ser Tyr Glu Asp Ser
                85                  90                  95      
Gly Val Tyr Ser Cys Arg His Ala His Lys Ser Met Leu Leu Ser Asn
            100                 105                 110         
Tyr Thr Val Lys Val Ile Asp Ser Leu Ser Ser Gly Asp Asp Glu Asp
        115                 120                 125             
Tyr Asp Glu Asp Glu Asp Glu Ala Gly Asn Gly Asn Ala Glu Ala Pro
    130                 135                 140                 
Tyr Trp Thr Arg Ser Asp Arg Met Glu Lys Lys Leu Leu Ala Val Pro
145                 150                 155                 160 
Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr
                165                 170                 175     
Pro Ser Ile His Trp Leu Lys Asn Gly Lys Glu Phe Lys Gly Glu Gln
            180                 185                 190         
Arg Met Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met
        195                 200                 205             
Glu Ser Ala Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Gln
    210                 215                 220                 
Asn Lys Tyr Gly Ser Ile Lys His Thr Tyr Gln Leu Asp Val Leu Glu
225                 230                 235                 240 
Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln
                245                 250                 255     
Thr Val Val Val Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser
            260                 265                 270         
Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly
        275                 280                 285             
Ser Gln Tyr Gly Pro Asn Gly Ala Pro Tyr Val Asn Val Leu Lys Thr
    290                 295                 300                 
Ala Gly Ile Asn Thr Thr Asp Lys Glu Leu Glu Ile Leu Tyr Leu Thr
305                 310                 315                 320 
Asn Val Ser Phe Glu Asp Ala Gly Gln Tyr Thr Cys Leu Ala Gly Asn
                325                 330                 335     
Ser Ile Gly Tyr Asn His His Ser Ala Trp Leu Thr Val Leu Pro Ala
            340                 345                 350         
Val Glu Met Glu Arg Glu Asp Asp Tyr Ala Asp Ile Leu Ile Tyr Val
        355                 360                 365             
Thr Ser Cys Val Leu Phe Ile Leu Thr Met Val Ile Ile Ile Leu Cys
    370                 375                 380                 
Arg Met Trp Ile Asn Thr Gln Lys Thr Leu Pro Ala Pro Pro Val Gln
385                 390                 395                 400 
Lys Leu Ser Lys Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn
                405                 410                 415     
Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser
            420                 425                 430         
Ser Ser Asp Gly Pro Met Leu Pro Asn Val Ser Glu Leu Glu Leu Pro
        435                 440                 445             
Ser Asp Pro Lys Trp Glu Phe Thr Arg Thr Lys Leu Thr Leu Gly Lys
    450                 455                 460                 
Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile
465                 470                 475                 480 
Gly Ile Asp Lys Glu Lys Pro Asn Lys Pro Leu Thr Val Ala Val Lys
                485                 490                 495     
Met Leu Lys Asp Asp Gly Thr Asp Lys Asp Leu Ser Asp Leu Val Ser
            500                 505                 510         
Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn
        515                 520                 525             
Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Leu Val Glu
    530                 535                 540                 
Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro
545                 550                 555                 560 
Pro Gly Met Asp Tyr Ser Phe Asp Thr Cys Lys Ile Pro Asn Glu Thr
                565                 570                 575     
Leu Thr Phe Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly
            580                 585                 590         
Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Pro Ala Ala
        595                 600                 605             
Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe
    610                 615                 620                 
Gly Leu Ala Arg Asp Val His Asn Ile Asp Tyr Tyr Lys Lys Thr Thr
625                 630                 635                 640 
Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp
                645                 650                 655     
Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Leu Leu
            660                 665                 670         
Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val
        675                 680                 685             
Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro
    690                 695                 700                 
Ala Asn Cys Thr His Glu Leu Tyr Met Ile Met Arg Glu Cys Trp His
705                 710                 715                 720 
Ala Val Pro Ser Gln Arg Pro Thr Phe Arg Gln Leu Val Glu Asp His
                725                 730                 735     
Asp Arg Val Leu Ser Met Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser
            740                 745                 750         
Val Pro Phe Glu Gln Tyr Ser Pro Thr Cys Pro Asp Ser Asn Ser Thr
        755                 760                 765             
Cys Ser Ser Gly Asp Asp Ser Val Phe Ala His Asp Pro Leu Pro Glu
    770                 775                 780                 
Glu Pro Cys Leu Pro Lys His His His Ser Asn Gly Val Ile Arg Thr
785                 790                 795                 800 


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer 1

<400> 29
agccctcact ccttctctag                                             20

<210> 30
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer 2

<400> 30
acctacaggt ggggtctttc attccc                                      26

<210> 31
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer 3

<400> 31
ccctgggtca agccctttgt acacc                                       25

<210> 32
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer 4

<400> 32
tgccaaacct acaggtgggg tcttt                                       25

<210> 33
<211> 604
<212> PRT
<213> Homo sapiens

<400> 33
Ala Gln Arg Arg Lys Glu Arg Glu Glu Leu Ala Gln Gln Tyr Glu Ala
 1               5                  10                  15      
Ile Leu Arg Glu Cys Gly His Gly Arg Phe Gln Trp Thr Leu Tyr Phe
            20                  25                  30          
Val Leu Gly Leu Ala Leu Met Ala Asp Gly Val Glu Val Phe Val Val
        35                  40                  45              
Gly Phe Val Leu Pro Ser Ala Glu Lys Asp Met Cys Leu Ser Asp Ser
    50                  55                  60                  
Asn Lys Gly Met Leu Gly Leu Ile Val Tyr Leu Gly Met Met Val Gly
65                  70                  75                  80  
Ala Phe Leu Trp Gly Gly Leu Ala Asp Arg Leu Gly Arg Arg Gln Cys
                85                  90                  95      
Leu Leu Ile Ser Leu Ser Val Asn Ser Val Phe Ala Phe Phe Ser Ser
            100                 105                 110         
Phe Val Gln Gly Tyr Gly Thr Phe Leu Phe Cys Arg Leu Leu Ser Gly
        115                 120                 125             
Val Gly Ile Gly Gly Ser Ile Pro Ile Val Phe Ser Tyr Phe Ser Glu
    130                 135                 140                 
Phe Leu Ala Gln Glu Lys Arg Gly Glu His Leu Ser Trp Leu Cys Met
145                 150                 155                 160 
Phe Trp Met Ile Gly Gly Val Tyr Ala Ala Ala Met Ala Trp Ala Ile
                165                 170                 175     
Ile Pro His Tyr Gly Trp Ser Phe Gln Met Gly Ser Ala Tyr Gln Phe
            180                 185                 190         
His Ser Trp Arg Val Phe Val Leu Val Cys Ala Phe Pro Ser Val Phe
        195                 200                 205             
Ala Ile Gly Ala Leu Thr Thr Gln Pro Glu Ser Pro Arg Phe Phe Leu
    210                 215                 220                 
Glu Asn Gly Lys His Asp Glu Ala Trp Met Val Leu Lys Gln Val His
225                 230                 235                 240 
Asp Thr Asn Met Arg Ala Lys Gly His Pro Glu Arg Val Phe Ser Val
                245                 250                 255     
Thr His Ile Lys Thr Ile His Gln Glu Asp Glu Leu Ile Glu Ile Gln
            260                 265                 270         
Ser Asp Thr Gly Thr Trp Tyr Gln Arg Trp Gly Val Arg Ala Leu Ser
        275                 280                 285             
Leu Gly Gly Gln Val Trp Gly Asn Phe Leu Ser Cys Phe Gly Pro Glu
    290                 295                 300                 
Tyr Arg Arg Ile Thr Leu Met Met Met Gly Val Trp Phe Thr Met Ser
305                 310                 315                 320 
Phe Ser Tyr Tyr Gly Leu Thr Val Trp Phe Pro Asp Met Ile Arg His
                325                 330                 335     
Leu Gln Ala Val Asp Tyr Ala Ser Arg Thr Lys Val Phe Pro Gly Glu
            340                 345                 350         
Arg Val Glu His Val Thr Phe Asn Phe Thr Leu Glu Asn Gln Ile His
        355                 360                 365             
Arg Gly Gly Gln Tyr Phe Asn Asp Lys Phe Ile Gly Leu Arg Leu Lys
    370                 375                 380                 
Ser Val Ser Phe Glu Asp Ser Leu Phe Glu Glu Cys Tyr Phe Glu Asp
385                 390                 395                 400 
Val Thr Ser Ser Asn Thr Phe Phe Arg Asn Cys Thr Phe Ile Asn Thr
                405                 410                 415     
Val Phe Tyr Asn Thr Asp Leu Phe Glu Tyr Lys Phe Val Asn Ser Arg
            420                 425                 430         
Leu Ile Asn Ser Thr Phe Leu His Asn Lys Glu Gly Cys Pro Leu Asp
        435                 440                 445             
Val Thr Gly Thr Gly Glu Gly Ala Tyr Met Val Tyr Phe Val Ser Phe
    450                 455                 460                 
Leu Gly Thr Leu Ala Val Leu Pro Gly Asn Ile Val Ser Ala Leu Leu
465                 470                 475                 480 
Met Asp Lys Ile Gly Arg Leu Arg Met Leu Ala Gly Ser Ser Val Met
                485                 490                 495     
Ser Cys Val Ser Cys Phe Phe Leu Ser Phe Gly Asn Ser Glu Ser Ala
            500                 505                 510         
Met Ile Ala Leu Leu Cys Leu Phe Gly Gly Val Ser Ile Ala Ser Trp
        515                 520                 525             
Asn Ala Leu Asp Val Leu Thr Val Glu Leu Tyr Pro Ser Asp Lys Arg
    530                 535                 540                 
Thr Thr Ala Phe Gly Phe Leu Asn Ala Leu Cys Lys Leu Ala Ala Val
545                 550                 555                 560 
Leu Gly Ile Ser Ile Phe Thr Ser Phe Val Gly Ile Thr Lys Ala Ala
                565                 570                 575     
Pro Ile Leu Phe Ala Ser Ala Ala Leu Ala Leu Gly Ser Ser Leu Ala
            580                 585                 590         
Leu Lys Leu Pro Glu Thr Arg Gly Gln Val Leu Gln
        595                 600                 


<210> 34
<211> 683
<212> PRT
<213> Homo sapiens

<400> 34
Met Asp Asp Tyr Lys Tyr Gln Asp Asn Tyr Gly Gly Tyr Ala Pro Ser
 1               5                  10                  15      
Asp Gly Tyr Tyr Arg Gly Asn Glu Ser Asn Pro Glu Glu Asp Ala Gln
            20                  25                  30          
Ser Asp Val Thr Glu Gly His Asp Glu Glu Asp Glu Ile Tyr Glu Gly
        35                  40                  45              
Glu Tyr Gln Gly Ile Pro His Pro Asp Asp Val Lys Ala Lys Gln Ala
    50                  55                  60                  
Lys Met Ala Pro Ser Arg Met Asp Ser Leu Arg Gly Gln Thr Asp Leu
65                  70                  75                  80  
Met Ala Glu Arg Leu Glu Asp Glu Glu Gln Leu Ala His Gln Tyr Glu
                85                  90                  95      
Thr Ile Met Asp Glu Cys Gly His Gly Arg Phe Gln Trp Ile Leu Phe
            100                 105                 110         
Phe Val Leu Gly Leu Ala Leu Met Ala Asp Gly Val Glu Val Phe Val
        115                 120                 125             
Val Ser Phe Ala Leu Pro Ser Ala Glu Lys Asp Met Cys Leu Ser Ser
    130                 135                 140                 
Ser Lys Lys Gly Met Leu Gly Met Ile Val Tyr Leu Gly Met Met Ala
145                 150                 155                 160 
Gly Ala Phe Ile Leu Gly Gly Leu Ala Asp Lys Leu Gly Arg Lys Arg
                165                 170                 175     
Val Leu Ser Met Ser Leu Ala Val Asn Ala Ser Phe Ala Ser Leu Ser
            180                 185                 190         
Ser Phe Val Gln Gly Tyr Gly Ala Phe Leu Phe Cys Arg Leu Ile Ser
        195                 200                 205             
Gly Ile Gly Ile Gly Gly Ala Leu Pro Ile Val Phe Ala Tyr Phe Ser
    210                 215                 220                 
Glu Phe Leu Ser Arg Glu Lys Arg Gly Glu His Leu Ser Trp Leu Gly
225                 230                 235                 240 
Ile Phe Trp Met Thr Gly Gly Leu Tyr Ala Ser Ala Met Ala Trp Ser
                245                 250                 255     
Ile Ile Pro His Tyr Gly Trp Gly Phe Ser Met Gly Thr Asn Tyr His
            260                 265                 270         
Phe His Ser Trp Arg Val Phe Val Ile Val Cys Ala Leu Pro Cys Thr
        275                 280                 285             
Val Ser Met Val Ala Leu Lys Phe Met Pro Glu Ser Pro Arg Phe Leu
    290                 295                 300                 
Leu Glu Met Gly Lys His Asp Glu Ala Trp Met Ile Leu Lys Gln Val
305                 310                 315                 320 
His Asp Thr Asn Met Arg Ala Lys Gly Thr Pro Glu Lys Val Phe Thr
                325                 330                 335     
Val Ser Asn Ile Lys Thr Pro Lys Gln Met Asp Glu Phe Ile Glu Ile
            340                 345                 350         
Gln Ser Ser Thr Gly Thr Trp Tyr Gln Arg Trp Leu Val Arg Phe Lys
        355                 360                 365             
Thr Ile Phe Lys Gln Val Trp Asp Asn Ala Leu Tyr Cys Val Met Gly
    370                 375                 380                 
Pro Tyr Arg Met Asn Thr Leu Ile Leu Ala Val Val Trp Phe Ala Met
385                 390                 395                 400 
Ala Phe Ser Tyr Tyr Gly Leu Thr Val Trp Phe Pro Asp Met Ile Arg
                405                 410                 415     
Tyr Phe Gln Asp Glu Glu Tyr Lys Ser Lys Met Lys Val Phe Phe Gly
            420                 425                 430         
Glu His Val Tyr Gly Ala Thr Ile Asn Phe Thr Met Glu Asn Gln Ile
        435                 440                 445             
His Gln His Gly Lys Leu Val Asn Asp Lys Phe Thr Arg Met Tyr Phe
    450                 455                 460                 
Lys His Val Leu Phe Glu Asp Thr Phe Phe Asp Glu Cys Tyr Phe Glu
465                 470                 475                 480 
Asp Val Thr Ser Thr Asp Thr Tyr Phe Lys Asn Cys Thr Ile Glu Ser
                485                 490                 495     
Thr Ile Phe Tyr Asn Thr Asp Leu Tyr Glu His Lys Phe Ile Asn Cys
            500                 505                 510         
Arg Phe Ile Asn Ser Thr Phe Leu Glu Gln Lys Glu Gly Cys His Met
        515                 520                 525             
Asp Leu Glu Gln Asp Asn Asp Phe Leu Ile Tyr Leu Val Ser Phe Leu
    530                 535                 540                 
Gly Ser Leu Ser Val Leu Pro Gly Asn Ile Ile Ser Ala Leu Leu Met
545                 550                 555                 560 
Asp Arg Ile Gly Arg Leu Lys Met Ile Gly Gly Ser Met Leu Ile Ser
                565                 570                 575     
Ala Val Cys Cys Phe Phe Leu Phe Phe Gly Asn Ser Glu Ser Ala Met
            580                 585                 590         
Ile Gly Trp Gln Cys Leu Phe Cys Gly Thr Ser Ile Ala Ala Trp Asn
        595                 600                 605             
Ala Leu Asp Val Ile Thr Val Glu Leu Tyr Pro Thr Asn Gln Arg Ala
    610                 615                 620                 
Thr Ala Phe Gly Ile Leu Asn Gly Leu Cys Lys Phe Gly Ala Ile Leu
625                 630                 635                 640 
Gly Asn Thr Ile Phe Ala Ser Phe Val Gly Ile Thr Lys Val Val Pro
                645                 650                 655     
Ile Leu Leu Ala Ala Ala Ser Leu Val Gly Gly Gly Leu Ile Ala Leu
            660                 665                 670         
Arg Leu Pro Glu Thr Arg Glu Gln Val Leu Ile
        675                 680             


<210> 35
<211> 727
<212> PRT
<213> Homo sapiens

<400> 35
Met Glu Asp Ser Tyr Lys Asp Arg Thr Ser Leu Met Lys Gly Ala Lys
 1               5                  10                  15      
Asp Ile Ala Arg Glu Val Lys Lys Gln Thr Val Lys Lys Val Asn Gln
            20                  25                  30          
Ala Val Asp Arg Ala Gln Asp Glu Tyr Thr Gln Arg Ser Tyr Ser Arg
        35                  40                  45              
Phe Gln Asp Glu Glu Asp Asp Asp Asp Tyr Tyr Pro Ala Gly Glu Thr
    50                  55                  60                  
Tyr Asn Gly Glu Ala Asn Asp Asp Glu Gly Ser Ser Glu Ala Thr Glu
65                  70                  75                  80  
Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly Glu Tyr Gln Gly Ile
                85                  90                  95      
Pro Ser Met Asn Gln Ala Lys Asp Ser Ile Val Ser Val Gly Gln Pro
            100                 105                 110         
Lys Gly Asp Glu Tyr Lys Asp Arg Arg Glu Leu Glu Ser Glu Arg Arg
        115                 120                 125             
Ala Asp Glu Glu Glu Leu Ala Gln Gln Tyr Glu Leu Ile Ile Gln Glu
    130                 135                 140                 
Cys Gly His Gly Arg Phe Gln Trp Ala Leu Phe Phe Val Leu Gly Met
145                 150                 155                 160 
Ala Leu Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu
                165                 170                 175     
Pro Ser Ala Glu Thr Asp Leu Cys Ile Pro Asn Ser Gly Ser Gly Trp
            180                 185                 190         
Leu Gly Ser Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Phe Trp
        195                 200                 205             
Gly Gly Leu Ala Asp Lys Val Gly Arg Lys Gln Ser Leu Leu Ile Cys
    210                 215                 220                 
Met Ser Val Asn Gly Phe Phe Ala Phe Leu Ser Ser Phe Val Gln Gly
225                 230                 235                 240 
Tyr Gly Phe Phe Leu Phe Cys Arg Leu Leu Ser Gly Phe Gly Ile Gly
                245                 250                 255     
Gly Ala Ile Pro Thr Val Phe Ser Tyr Phe Ala Glu Val Leu Ala Arg
            260                 265                 270         
Glu Lys Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile
        275                 280                 285             
Gly Gly Ile Tyr Ala Ser Ala Met Ala Trp Ala Ile Ile Pro His Tyr
    290                 295                 300                 
Gly Trp Ser Phe Ser Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg
305                 310                 315                 320 
Val Phe Val Ile Val Cys Ala Leu Pro Cys Val Ser Ser Val Val Ala
                325                 330                 335     
Leu Thr Phe Met Pro Glu Ser Pro Arg Phe Leu Leu Glu Val Gly Lys
            340                 345                 350         
His Asp Glu Ala Trp Met Ile Leu Lys Leu Ile His Asp Thr Asn Met
        355                 360                 365             
Arg Ala Arg Gly Gln Pro Glu Lys Val Phe Thr Val Asn Lys Ile Lys
    370                 375                 380                 
Thr Pro Lys Gln Ile Asp Glu Leu Ile Glu Ile Glu Ser Asp Thr Gly
385                 390                 395                 400 
Thr Trp Tyr Arg Arg Cys Phe Val Arg Ile Arg Thr Glu Leu Tyr Gly
                405                 410                 415     
Ile Trp Leu Thr Phe Met Arg Cys Phe Asn Tyr Pro Val Arg Asp Asn
            420                 425                 430         
Thr Ile Lys Leu Thr Ile Val Trp Phe Thr Leu Ser Phe Gly Tyr Tyr
        435                 440                 445             
Gly Leu Ser Val Trp Phe Pro Asp Val Ile Lys Pro Leu Gln Ser Asp
    450                 455                 460                 
Glu Tyr Ala Leu Leu Thr Arg Asn Val Glu Arg Asp Lys Tyr Ala Asn
465                 470                 475                 480 
Phe Thr Ile Asn Phe Thr Met Glu Asn Gln Ile His Thr Gly Met Glu
                485                 490                 495     
Tyr Asp Asn Gly Arg Phe Ile Gly Val Lys Phe Lys Ser Val Thr Phe
            500                 505                 510         
Lys Asp Ser Val Phe Lys Ser Cys Thr Phe Glu Asp Val Thr Ser Val
        515                 520                 525             
Asn Thr Tyr Phe Lys Asn Cys Thr Phe Ile Asp Thr Val Phe Asp Asn
    530                 535                 540                 
Thr Asp Phe Glu Pro Tyr Lys Phe Ile Asp Ser Glu Phe Lys Asn Cys
545                 550                 555                 560 
Ser Phe Phe His Asn Lys Thr Gly Cys Gln Ile Thr Phe Asp Asp Asp
                565                 570                 575     
Tyr Ser Ala Tyr Trp Ile Tyr Phe Val Asn Phe Leu Gly Thr Leu Ala
            580                 585                 590         
Val Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Arg Ile Gly
        595                 600                 605             
Arg Leu Thr Met Leu Gly Gly Ser Met Val Leu Ser Gly Ile Ser Cys
    610                 615                 620                 
Phe Phe Leu Trp Phe Gly Thr Ser Glu Ser Met Met Ile Gly Met Leu
625                 630                 635                 640 
Cys Leu Tyr Asn Gly Leu Thr Ile Ser Ala Trp Asn Ser Leu Asp Val
                645                 650                 655     
Val Thr Val Glu Leu Tyr Pro Thr Asp Arg Arg Ala Thr Gly Phe Gly
            660                 665                 670         
Phe Leu Asn Ala Leu Cys Lys Ala Ala Ala Val Leu Gly Asn Leu Ile
        675                 680                 685             
Phe Gly Ser Leu Val Ser Ile Thr Lys Ser Ile Pro Ile Leu Leu Ala
    690                 695                 700                 
Ser Thr Val Leu Val Cys Gly Gly Leu Val Gly Leu Cys Leu Pro Asp
705                 710                 715                 720 
Thr Arg Thr Gln Val Leu Met
                725         


<210> 36
<211> 742
<212> PRT
<213> Homo sapiens

<400> 36
Met Glu Glu Gly Phe Arg Asp Arg Ala Ala Phe Ile Arg Gly Ala Lys
 1               5                  10                  15      
Asp Ile Ala Lys Glu Val Lys Lys His Ala Ala Lys Lys Val Val Lys
            20                  25                  30          
Gly Leu Asp Arg Val Gln Asp Glu Tyr Ser Arg Arg Ser Tyr Ser Arg
        35                  40                  45              
Phe Glu Glu Glu Asp Asp Asp Asp Asp Phe Pro Ala Pro Ser Asp Gly
    50                  55                  60                  
Tyr Tyr Arg Gly Glu Gly Thr Gln Asp Glu Glu Glu Gly Gly Ala Ser
65                  70                  75                  80  
Ser Asp Ala Thr Glu Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly
                85                  90                  95      
Glu Tyr Gln Asp Ile Pro Arg Ala Glu Ser Gly Gly Lys Gly Glu Arg
            100                 105                 110         
Met Ala Asp Gly Ala Pro Leu Ala Gly Val Arg Gly Gly Leu Ser Asp
        115                 120                 125             
Gly Glu Gly Pro Pro Gly Gly Arg Gly Glu Ala Gln Arg Arg Lys Glu
    130                 135                 140                 
Arg Glu Glu Leu Ala Gln Gln Tyr Glu Ala Ile Leu Arg Glu Cys Gly
145                 150                 155                 160 
His Gly Arg Phe Gln Trp Thr Leu Tyr Phe Val Leu Gly Leu Ala Leu
                165                 170                 175     
Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu Pro Ser
            180                 185                 190         
Ala Glu Lys Asp Met Cys Leu Ser Asp Ser Asn Lys Gly Met Leu Gly
        195                 200                 205             
Leu Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Leu Trp Gly Gly
    210                 215                 220                 
Leu Ala Asp Arg Leu Gly Arg Arg Gln Cys Leu Leu Ile Ser Leu Ser
225                 230                 235                 240 
Val Asn Ser Val Phe Ala Phe Phe Ser Ser Phe Val Gln Gly Tyr Gly
                245                 250                 255     
Thr Phe Leu Phe Cys Arg Leu Leu Ser Gly Val Gly Ile Gly Gly Ser
            260                 265                 270         
Ile Pro Ile Val Phe Ser Tyr Phe Ser Glu Phe Leu Ala Gln Glu Lys
        275                 280                 285             
Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile Gly Gly
    290                 295                 300                 
Val Tyr Ala Ala Ala Met Ala Trp Ala Ile Ile Pro His Tyr Gly Trp
305                 310                 315                 320 
Ser Phe Gln Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg Val Phe
                325                 330                 335     
Val Leu Val Cys Ala Phe Pro Ser Val Phe Ala Ile Gly Ala Leu Thr
            340                 345                 350         
Thr Gln Pro Glu Ser Pro Arg Phe Phe Leu Glu Asn Gly Lys His Asp
        355                 360                 365             
Glu Ala Trp Met Val Leu Lys Gln Val His Asp Thr Asn Met Arg Ala
    370                 375                 380                 
Lys Gly His Pro Glu Arg Val Phe Ser Val Thr His Ile Lys Thr Ile
385                 390                 395                 400 
His Gln Glu Asp Glu Leu Ile Glu Ile Gln Ser Asp Thr Gly Thr Trp
                405                 410                 415     
Tyr Gln Arg Trp Gly Val Arg Ala Leu Ser Leu Gly Gly Gln Val Trp
            420                 425                 430         
Gly Asn Phe Leu Ser Cys Phe Gly Pro Glu Tyr Arg Arg Ile Thr Leu
        435                 440                 445             
Met Met Met Gly Val Trp Phe Thr Met Ser Phe Ser Tyr Tyr Gly Leu
    450                 455                 460                 
Thr Val Trp Phe Pro Asp Met Ile Arg His Leu Gln Ala Val Asp Tyr
465                 470                 475                 480 
Ala Ser Arg Thr Lys Val Phe Pro Gly Glu Arg Val Gly His Val Thr
                485                 490                 495     
Phe Asn Phe Thr Leu Glu Asn Gln Ile His Arg Gly Gly Gln Tyr Phe
            500                 505                 510         
Asn Asp Lys Phe Ile Gly Leu Arg Leu Lys Ser Val Ser Phe Glu Asp
        515                 520                 525             
Ser Leu Phe Glu Glu Cys Tyr Phe Glu Asp Val Thr Ser Ser Asn Thr
    530                 535                 540                 
Phe Phe Arg Asn Cys Thr Phe Ile Asn Thr Val Phe Tyr Asn Thr Asp
545                 550                 555                 560 
Leu Phe Glu Tyr Lys Phe Val Asn Ser Arg Leu Ile Asn Ser Thr Phe
                565                 570                 575     
Leu His Asn Lys Glu Gly Cys Pro Leu Asp Val Thr Gly Thr Gly Glu
            580                 585                 590         
Gly Ala Tyr Met Val Tyr Phe Val Ser Phe Leu Gly Thr Leu Ala Val
        595                 600                 605             
Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Lys Ile Gly Arg
    610                 615                 620                 
Leu Arg Met Leu Ala Gly Ser Ser Val Met Ser Cys Val Ser Cys Phe
625                 630                 635                 640 
Phe Leu Ser Phe Gly Asn Ser Glu Ser Ala Met Ile Ala Leu Leu Cys
                645                 650                 655     
Leu Phe Gly Gly Val Ser Ile Ala Ser Trp Asn Ala Leu Asp Val Leu
            660                 665                 670         
Thr Val Glu Leu Tyr Pro Ser Asp Lys Arg Thr Thr Ala Phe Gly Phe
        675                 680                 685             
Leu Asn Ala Leu Cys Lys Leu Ala Ala Val Leu Gly Ile Ser Ile Phe
    690                 695                 700                 
Thr Ser Phe Val Gly Ile Thr Lys Ala Ala Pro Ile Leu Phe Ala Ser
705                 710                 715                 720 
Ala Ala Leu Ala Leu Gly Ser Ser Leu Ala Leu Lys Leu Pro Glu Thr
                725                 730                 735     
Arg Gly Gln Val Leu Gln
            740         


<210> 37
<211> 4654
<212> DNA
<213> Homo sapiens

<400> 37
ggcggcggct ggaggagagc gcggtggaga gccgagcggg cgggcggcgg gtgcggagcg 60
ggcgagggag cgcgcgcggc cgccacaaag ctcgggcgcc gcggggctgc atgcggcgta 120
cctggcccgg cgcggcgact gctctccggg ctggcggggg ccggccgcga gccccggggg 180
ccccgaggcc gcagcttgcc tgcgcgctct gagccttcgc aactcgcgag caaagtttgg 240
tggaggcaac gccaagcctg agtcctttct tcctctcgtt ccccaaatcc gagggcagcc 300
cgcgggcgtc atgcccgcgc tcctccgcag cctggggtac gcgtgaagcc cgggaggctt 360
ggcgccggcg aagacccaag gaccactctt ctgcgtttgg agttgctccc cgcaaccccg 420
ggctcgtcgc tttctccatc ccgacccacg cggggcgcgg ggacaacaca ggtcgcggag 480
gagcgttgcc attcaagtga ctgcagcagc agcggcagcg cctcggttcc tgagcccacc 540
gcaggctgaa ggcattgcgc gtagtccatg cccgtagagg aagtgtgcag atgggattaa 600
cgtccacatg gagatatgga agaggaccgg ggattggtac cgtaaccatg gtcagctggg 660
gtcgtttcat ctgcctggtc gtggtcacca tggcaacctt gtccctggcc cggccctcct 720
tcagtttagt tgaggatacc acattagagc cagaagagcc accaaccaaa taccaaatct 780
ctcaaccaga agtgtacgtg gctgcgccag gggagtcgct agaggtgcgc tgcctgttga 840
aagatgccgc cgtgatcagt tggactaagg atggggtgca cttggggccc aacaatagga 900
cagtgcttat tggggagtac ttgcagataa agggcgccac gcctagagac tccggcctct 960
atgcttgtac tgccagtagg actgtagaca gtgaaacttg gtacttcatg gtgaatgtca 1020
cagatgccat ctcatccgga gatgatgagg atgacaccga tggtgcggaa gattttgtca 1080
gtgagaacag taacaacaag agagcaccat actggaccaa cacagaaaag atggaaaagc 1140
ggctccatgc tgtgcctgcg gccaacactg tcaagtttcg ctgcccagcc ggggggaacc 1200
caatgccaac catgcggtgg ctgaaaaacg ggaaggagtt taagcaggag catcgcattg 1260
gaggctacaa ggtacgaaac cagcactgga gcctcattat ggaaagtgtg gtcccatctg 1320
acaagggaaa ttatacctgt gtagtggaga atgaatacgg gtccatcaat cacacgtacc 1380
acctggatgt tgtggagcga tcgcctcacc ggcccatcct ccaagccgga ctgccggcaa 1440
atgcctccac agtggtcgga ggagacgtag agtttgtctg caaggtttac agtgatgccc 1500
agccccacat ccagtggatc aagcacgtgg aaaagaacgg cagtaaatac gggcccgacg 1560
ggctgcccta cctcaaggtt ctcaaggccg ccggtgttaa caccacggac aaagagattg 1620
aggttctcta tattcggaat gtaacttttg aggacgctgg ggaatatacg tgcttggcgg 1680
gtaattctat tgggatatcc tttcactctg catggttgac agttctgcca gcgcctggaa 1740
gagaaaagga gattacagct tccccagact acctggagat agccatttac tgcatagggg 1800
tcttcttaat cgcctgtatg gtggtaacag tcatcctgtg ccgaatgaag aacacgacca 1860
agaagccaga cttcagcagc cagccggctg tgcacaagct gaccaaacgt atccccctgc 1920
ggagacaggt aacagtttcg gctgagtcca gctcctccat gaactccaac accccgctgg 1980
tgaggataac aacacgcctc tcttcaacgg cagacacccc catgctggca ggggtctccg 2040
agtatgaact tccagaggac ccaaaatggg agtttccaag agataagctg acactgggca 2100
agcccctggg agaaggttgc tttgggcaag tggtcatggc ggaagcagtg ggaattgaca 2160
aagacaagcc caaggaggcg gtcaccgtgg ccgtgaagat gttgaaagat gatgccacag 2220
agaaagacct ttctgatctg gtgtcagaga tggagatgat gaagatgatt gggaaacaca 2280
agaatatcat aaatcttctt ggagcctgca cacaggatgg gcctctctat gtcatagttg 2340
agtatgcctc taaaggcaac ctccgagaat acctccgagc ccggaggcca cccgggatgg 2400
agtactccta tgacattaac cgtgttcctg aggagcagat gaccttcaag gacttggtgt 2460
catgcaccta ccagctggcc agaggcatgg agtacttggc ttcccaaaaa tgtattcatc 2520
gagatttagc agccagaaat gttttggtaa cagaaaacaa tgtgatgaaa atagcagact 2580
ttggactcgc cagagatatc aacaatatag actattacaa aaagaccacc aatgggcggc 2640
ttccagtcaa gtggatggct ccagaagccc tgtttgatag agtatacact catcagagtg 2700
atgtctggtc cttcggggtg ttaatgtggg agatcttcac tttagggggc tcgccctacc 2760
cagggattcc cgtggaggaa ctttttaagc tgctgaagga aggacacaga atggataagc 2820
cagccaactg caccaacgaa ctgtacatga tgatgaggga ctgttggcat gcagtgccct 2880
cccagagacc aacgttcaag cagttggtag aagacttgga tcgaattctc actctcacaa 2940
ccaatgagga atacttggac ctcagccaac ctctcgaaca gtattcacct agttaccctg 3000
acacaagaag ttcttgttct tcaggagatg attctgtttt ttctccagac cccatgcctt 3060
acgaaccatg ccttcctcag tatccacaca taaacggcag tgttaaaaca tgaatgactg 3120
tgtctgcctg tccccaaaca ggacagcact gggaacctag ctacactgag cagggagacc 3180
atgcctccca gagcttgttg tctccacttg tatatatgga tcagaggagt aaataattgg 3240
aaaagtaatc agcatatgtg taaagattta tacagttgaa aacttgtaat cttccccagg 3300
aggagaagaa ggtttctgga gcagtggact gccacaagcc accatgtaac ccctctcacc 3360
tgccgtgcgt actggctgtg gaccagtagg actcaaggtg gacgtgcgtt ctgccttcct 3420
tgttaatttt gtaataattg gagaagattt atgtcagcac acacttacag agcacaaatg 3480
cagtatatag gtgctggatg tatgtaaata tattcaaatt atgtataaat atatattata 3540
tatttacaag gagttatttt ttgtattgat tttaaatgga tgtcccaatg cacctagaaa 3600
attggtctct ctttttttaa tagctatttg ctaaatgctg ttcttacaca taatttctta 3660
attttcaccg agcagaggtg gaaaaatact tttgctttca gggaaaatgg tataacgtta 3720
atttattaat aaattggtaa tatacaaaac aattaatcat ttatagtttt ttttgtaatt 3780
taagtggcat ttctatgcag gcagcacagc agactagtta atctattgct tggacttaac 3840
tagttatcag atcctttgaa aagagaatat ttacaatata tgactaattt ggggaaaatg 3900
aagttttgat ttatttgtgt ttaaatgctg ctgtcagacg attgttctta gacctcctaa 3960
atgccccata ttaaaagaac tcattcatag gaaggtgttt cattttggtg tgcaaccctg 4020
tcattacgtc aacgcaacgt ctaactggac ttcccaagat aaatggtacc agcgtcctct 4080
taaaagatgc cttaatccat tccttgagga cagaccttag ttgaaatgat agcagaatgt 4140
gcttctctct ggcagctggc cttctgcttc tgagttgcac attaatcaga ttagcctgta 4200
ttctcttcag tgaattttga taatggcttc cagactcttt ggcgttggag acgcctgtta 4260
ggatcttcaa gtcccatcat agaaaattga aacacagagt tgttctgctg atagttttgg 4320
ggatacgtcc atctttttaa gggattgctt tcatctaatt ctggcaggac ctcaccaaaa 4380
gatccagcct catacctaca tcagacaaaa tatcgccgtt gttccttctg tactaaagta 4440
ttgtgttttg ctttggaaac acccactcac tttgcaatag ccgtgcaaga tgaatgcaga 4500
ttacactgat cttatgtgtt acaaaattgg agaaagtatt taataaaacc tgttaatttt 4560
tatactgaca ataaaaatgt ttctacagat attaatgtta acaagacaaa ataaatgtca 4620
cgcaacttat ttttttaata aaaaaaaaaa aaaa                             4654

<210> 38
<211> 821
<212> PRT
<213> Homo sapiens

<400> 38
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly
            260                 265                 270         
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile
        275                 280                 285             
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr
305                 310                 315                 320 
Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp
                325                 330                 335     
Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe
            340                 345                 350         
His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu
        355                 360                 365             
Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly
    370                 375                 380                 
Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met
385                 390                 395                 400 
Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His
                405                 410                 415     
Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala
            420                 425                 430         
Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr
        435                 440                 445             
Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser
    450                 455                 460                 
Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys
465                 470                 475                 480 
Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val
                485                 490                 495     
Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val
            500                 505                 510         
Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu
        515                 520                 525             
Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His
    530                 535                 540                 
Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu
545                 550                 555                 560 
Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu
                565                 570                 575     
Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg
            580                 585                 590         
Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr
        595                 600                 605             
Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His
    610                 615                 620                 
Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met
625                 630                 635                 640 
Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr
                645                 650                 655     
Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro
            660                 665                 670         
Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser
        675                 680                 685             
Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr
    690                 695                 700                 
Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His
705                 710                 715                 720 
Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met
                725                 730                 735     
Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln
            740                 745                 750         
Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu
        755                 760                 765             
Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro
    770                 775                 780                 
Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro
785                 790                 795                 800 
Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn
                805                 810                 815     
Gly Ser Val Lys Thr
            820     


<210> 39
<211> 4657
<212> DNA
<213> Homo sapiens

<400> 39
ggcggcggct ggaggagagc gcggtggaga gccgagcggg cgggcggcgg gtgcggagcg 60
ggcgagggag cgcgcgcggc cgccacaaag ctcgggcgcc gcggggctgc atgcggcgta 120
cctggcccgg cgcggcgact gctctccggg ctggcggggg ccggccgcga gccccggggg 180
ccccgaggcc gcagcttgcc tgcgcgctct gagccttcgc aactcgcgag caaagtttgg 240
tggaggcaac gccaagcctg agtcctttct tcctctcgtt ccccaaatcc gagggcagcc 300
cgcgggcgtc atgcccgcgc tcctccgcag cctggggtac gcgtgaagcc cgggaggctt 360
ggcgccggcg aagacccaag gaccactctt ctgcgtttgg agttgctccc cgcaaccccg 420
ggctcgtcgc tttctccatc ccgacccacg cggggcgcgg ggacaacaca ggtcgcggag 480
gagcgttgcc attcaagtga ctgcagcagc agcggcagcg cctcggttcc tgagcccacc 540
gcaggctgaa ggcattgcgc gtagtccatg cccgtagagg aagtgtgcag atgggattaa 600
cgtccacatg gagatatgga agaggaccgg ggattggtac cgtaaccatg gtcagctggg 660
gtcgtttcat ctgcctggtc gtggtcacca tggcaacctt gtccctggcc cggccctcct 720
tcagtttagt tgaggatacc acattagagc cagaagagcc accaaccaaa taccaaatct 780
ctcaaccaga agtgtacgtg gctgcgccag gggagtcgct agaggtgcgc tgcctgttga 840
aagatgccgc cgtgatcagt tggactaagg atggggtgca cttggggccc aacaatagga 900
cagtgcttat tggggagtac ttgcagataa agggcgccac gcctagagac tccggcctct 960
atgcttgtac tgccagtagg actgtagaca gtgaaacttg gtacttcatg gtgaatgtca 1020
cagatgccat ctcatccgga gatgatgagg atgacaccga tggtgcggaa gattttgtca 1080
gtgagaacag taacaacaag agagcaccat actggaccaa cacagaaaag atggaaaagc 1140
ggctccatgc tgtgcctgcg gccaacactg tcaagtttcg ctgcccagcc ggggggaacc 1200
caatgccaac catgcggtgg ctgaaaaacg ggaaggagtt taagcaggag catcgcattg 1260
gaggctacaa ggtacgaaac cagcactgga gcctcattat ggaaagtgtg gtcccatctg 1320
acaagggaaa ttatacctgt gtagtggaga atgaatacgg gtccatcaat cacacgtacc 1380
acctggatgt tgtggagcga tcgcctcacc ggcccatcct ccaagccgga ctgccggcaa 1440
atgcctccac agtggtcgga ggagacgtag agtttgtctg caaggtttac agtgatgccc 1500
agccccacat ccagtggatc aagcacgtgg aaaagaacgg cagtaaatac gggcccgacg 1560
ggctgcccta cctcaaggtt ctcaagcact cggggataaa tagttccaat gcagaagtgc 1620
tggctctgtt caatgtgacc gaggcggatg ctggggaata tatatgtaag gtctccaatt 1680
atatagggca ggccaaccag tctgcctggc tcactgtcct gccaaaacag caagcgcctg 1740
gaagagaaaa ggagattaca gcttccccag actacctgga gatagccatt tactgcatag 1800
gggtcttctt aatcgcctgt atggtggtaa cagtcatcct gtgccgaatg aagaacacga 1860
ccaagaagcc agacttcagc agccagccgg ctgtgcacaa gctgaccaaa cgtatccccc 1920
tgcggagaca ggtaacagtt tcggctgagt ccagctcctc catgaactcc aacaccccgc 1980
tggtgaggat aacaacacgc ctctcttcaa cggcagacac ccccatgctg gcaggggtct 2040
ccgagtatga acttccagag gacccaaaat gggagtttcc aagagataag ctgacactgg 2100
gcaagcccct gggagaaggt tgctttgggc aagtggtcat ggcggaagca gtgggaattg 2160
acaaagacaa gcccaaggag gcggtcaccg tggccgtgaa gatgttgaaa gatgatgcca 2220
cagagaaaga cctttctgat ctggtgtcag agatggagat gatgaagatg attgggaaac 2280
acaagaatat cataaatctt cttggagcct gcacacagga tgggcctctc tatgtcatag 2340
ttgagtatgc ctctaaaggc aacctccgag aatacctccg agcccggagg ccacccggga 2400
tggagtactc ctatgacatt aaccgtgttc ctgaggagca gatgaccttc aaggacttgg 2460
tgtcatgcac ctaccagctg gccagaggca tggagtactt ggcttcccaa aaatgtattc 2520
atcgagattt agcagccaga aatgttttgg taacagaaaa caatgtgatg aaaatagcag 2580
actttggact cgccagagat atcaacaata tagactatta caaaaagacc accaatgggc 2640
ggcttccagt caagtggatg gctccagaag ccctgtttga tagagtatac actcatcaga 2700
gtgatgtctg gtccttcggg gtgttaatgt gggagatctt cactttaggg ggctcgccct 2760
acccagggat tcccgtggag gaacttttta agctgctgaa ggaaggacac agaatggata 2820
agccagccaa ctgcaccaac gaactgtaca tgatgatgag ggactgttgg catgcagtgc 2880
cctcccagag accaacgttc aagcagttgg tagaagactt ggatcgaatt ctcactctca 2940
caaccaatga ggaatacttg gacctcagcc aacctctcga acagtattca cctagttacc 3000
ctgacacaag aagttcttgt tcttcaggag atgattctgt tttttctcca gaccccatgc 3060
cttacgaacc atgccttcct cagtatccac acataaacgg cagtgttaaa acatgaatga 3120
ctgtgtctgc ctgtccccaa acaggacagc actgggaacc tagctacact gagcagggag 3180
accatgcctc ccagagcttg ttgtctccac ttgtatatat ggatcagagg agtaaataat 3240
tggaaaagta atcagcatat gtgtaaagat ttatacagtt gaaaacttgt aatcttcccc 3300
aggaggagaa gaaggtttct ggagcagtgg actgccacaa gccaccatgt aacccctctc 3360
acctgccgtg cgtactggct gtggaccagt aggactcaag gtggacgtgc gttctgcctt 3420
ccttgttaat tttgtaataa ttggagaaga tttatgtcag cacacactta cagagcacaa 3480
atgcagtata taggtgctgg atgtatgtaa atatattcaa attatgtata aatatatatt 3540
atatatttac aaggagttat tttttgtatt gattttaaat ggatgtccca atgcacctag 3600
aaaattggtc tctctttttt taatagctat ttgctaaatg ctgttcttac acataatttc 3660
ttaattttca ccgagcagag gtggaaaaat acttttgctt tcagggaaaa tggtataacg 3720
ttaatttatt aataaattgg taatatacaa aacaattaat catttatagt tttttttgta 3780
atttaagtgg catttctatg caggcagcac agcagactag ttaatctatt gcttggactt 3840
aactagttat cagatccttt gaaaagagaa tatttacaat atatgactaa tttggggaaa 3900
atgaagtttt gatttatttg tgtttaaatg ctgctgtcag acgattgttc ttagacctcc 3960
taaatgcccc atattaaaag aactcattca taggaaggtg tttcattttg gtgtgcaacc 4020
ctgtcattac gtcaacgcaa cgtctaactg gacttcccaa gataaatggt accagcgtcc 4080
tcttaaaaga tgccttaatc cattccttga ggacagacct tagttgaaat gatagcagaa 4140
tgtgcttctc tctggcagct ggccttctgc ttctgagttg cacattaatc agattagcct 4200
gtattctctt cagtgaattt tgataatggc ttccagactc tttggcgttg gagacgcctg 4260
ttaggatctt caagtcccat catagaaaat tgaaacacag agttgttctg ctgatagttt 4320
tggggatacg tccatctttt taagggattg ctttcatcta attctggcag gacctcacca 4380
aaagatccag cctcatacct acatcagaca aaatatcgcc gttgttcctt ctgtactaaa 4440
gtattgtgtt ttgctttgga aacacccact cactttgcaa tagccgtgca agatgaatgc 4500
agattacact gatcttatgt gttacaaaat tggagaaagt atttaataaa acctgttaat 4560
ttttatactg acaataaaaa tgtttctaca gatattaatg ttaacaagac aaaataaatg 4620
tcacgcaact tattttttta ataaaaaaaa aaaaaaa                          4657

<210> 40
<211> 822
<212> PRT
<213> Homo sapiens

<400> 40
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly
            260                 265                 270         
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile
        275                 280                 285             
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser
305                 310                 315                 320 
Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly
                325                 330                 335     
Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser
            340                 345                 350         
Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys
        355                 360                 365             
Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile
    370                 375                 380                 
Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg
385                 390                 395                 400 
Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val
                405                 410                 415     
His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser
            420                 425                 430         
Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile
        435                 440                 445             
Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val
    450                 455                 460                 
Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp
465                 470                 475                 480 
Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val
                485                 490                 495     
Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala
            500                 505                 510         
Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp
        515                 520                 525             
Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys
    530                 535                 540                 
His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro
545                 550                 555                 560 
Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr
                565                 570                 575     
Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn
            580                 585                 590         
Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr
        595                 600                 605             
Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile
    610                 615                 620                 
His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val
625                 630                 635                 640 
Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp
                645                 650                 655     
Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala
            660                 665                 670         
Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp
        675                 680                 685             
Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro
    690                 695                 700                 
Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly
705                 710                 715                 720 
His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met
                725                 730                 735     
Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys
            740                 745                 750         
Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu
        755                 760                 765             
Glu Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr
    770                 775                 780                 
Pro Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser
785                 790                 795                 800 
Pro Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile
                805                 810                 815     
Asn Gly Ser Val Lys Thr
            820         


<210> 41
<211> 2781
<212> DNA
<213> Homo sapiens

<400> 41
tgactgcagc agcagcggca gcgcctcggt tcctgagccc accgcaggct gaaggcattg 60
cgcgtagtcc atgcccgtag aggaagtgtg cagatgggat taacgtccac atggagatat 120
ggaagaggac cggggattgg taccgtaacc atggtcagct ggggtcgttt catctgcctg 180
gtcgtggtca ccatggcaac cttgtccctg gcccggccct ccttcagttt agttgaggat 240
accacattag agccagaaga gccaccaacc aaataccaaa tctctcaacc agaagtgtac 300
gtggctgcgc caggggagtc gctagaggtg cgctgcctgt tgaaagatgc cgccgtgatc 360
agttggacta aggatggggt gcacttgggg cccaacaata ggacagtgct tattggggag 420
tacttgcaga taaagggcgc cacgcctaga gactccggcc tctatgcttg tactgccagt 480
aggactgtag acagtgaaac ttggtacttc atggtgaatg tcacagatgc catctcatcc 540
ggagatgatg aggatgacac cgatggtgcg gaagattttg tcagtgagaa cagtaacaac 600
aagagagcac catactggac caacacagaa aagatggaaa agcggctcca tgctgtgcct 660
gcggccaaca ctgtcaagtt tcgctgccca gccgggggga acccaatgcc aaccatgcgg 720
tggctgaaaa acgggaagga gtttaagcag gagcatcgca ttggaggcta caaggtacga 780
aaccagcact ggagcctcat tatggaaagt gtggtcccat ctgacaaggg aaattatacc 840
tgtgtagtgg agaatgaata cgggtccatc aatcacacgt accacctgga tgttgtggag 900
cgatcgcctc accggcccat cctccaagcc ggactgccgg caaatgcctc cacagtggtc 960
ggaggagacg tagagtttgt ctgcaaggtt tacagtgatg cccagcccca catccagtgg 1020
atcaagcacg tggaaaagaa cggcagtaaa tacgggcccg acgggctgcc ctacctcaag 1080
gttctcaagc actcggggat aaatagttcc aatgcagaag tgctggctct gttcaatgtg 1140
accgaggcgg atgctgggga atatatatgt aaggtctcca attatatagg gcaggccaac 1200
cagtctgcct ggctcactgt cctgccaaaa cagcaagcgc ctggaagaga aaaggagatt 1260
acagcttccc cagactacct ggagatagcc atttactgca taggggtctt cttaatcgcc 1320
tgtatggtgg taacagtcat cctgtgccga atgaagaaca cgaccaagaa gccagacttc 1380
agcagccagc cggctgtgca caagctgacc aaacgtatcc ccctgcggag acaggtaaca 1440
gtttcggctg agtccagctc ctccatgaac tccaacaccc cgctggtgag gataacaaca 1500
cgcctctctt caacggcaga cacccccatg ctggcagggg tctccgagta tgaacttcca 1560
gaggacccaa aatgggagtt tccaagagat aagctgacac tgggcaagcc cctgggagaa 1620
ggttgctttg ggcaagtggt catggcggaa gcagtgggaa ttgacaaaga caagcccaag 1680
gaggcggtca ccgtggccgt gaagatgttg aaagatgatg ccacagagaa agacctttct 1740
gatctggtgt cagagatgga gatgatgaag atgattggga aacacaagaa tatcataaat 1800
cttcttggag cctgcacaca ggatgggcct ctctatgtca tagttgagta tgcctctaaa 1860
ggcaacctcc gagaatacct ccgagcccgg aggccacccg ggatggagta ctcctatgac 1920
attaaccgtg ttcctgagga gcagatgacc ttcaaggact tggtgtcatg cacctaccag 1980
ctggccagag gcatggagta cttggcttcc caaaaatgta ttcatcgaga tttagcagcc 2040
agaaatgttt tggtaacaga aaacaatgtg atgaaaatag cagactttgg actcgccaga 2100
gatatcaaca atatagacta ttacaaaaag accaccaatg ggcggcttcc agtcaagtgg 2160
atggctccag aagccctgtt tgatagagta tacactcatc agagtgatgt ctggtccttc 2220
ggggtgttaa tgtgggagat cttcacttta gggggctcgc cctacccagg gattcccgtg 2280
gaggaacttt ttaagctgct gaaggaagga cacagaatgg ataagccagc caactgcacc 2340
aacgaactgt acatgatgat gagggactgt tggcatgcag tgccctccca gagaccaacg 2400
ttcaagcagt tggtagaaga cttggatcga attctcactc tcacaaccaa tgagatctga 2460
aagtttatgg cttcattgag aaactgggaa aagttggtca ggcgcagtgg ctcatgcctg 2520
taatcccagc actttgggag gccgaggcag gcggatcatg aggtcaggag ttccagacca 2580
gcctggccaa catggtgaaa ccctgtctct actaaagata caaaaaatta gccgggcgtg 2640
ttggtgtgca cctgtaatcc cagctactcc gggaggctga ggcaggagag tcacttgaac 2700
cggggaggcg gaggttgcag tgagccgaga tcatgccatt gcattccagc cttggcgaca 2760
gagcgagact ccgtctcaaa a                                           2781

<210> 42
<211> 769
<212> PRT
<213> Homo sapiens

<400> 42
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly
            260                 265                 270         
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile
        275                 280                 285             
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser
305                 310                 315                 320 
Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly
                325                 330                 335     
Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser
            340                 345                 350         
Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys
        355                 360                 365             
Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile
    370                 375                 380                 
Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg
385                 390                 395                 400 
Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val
                405                 410                 415     
His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser
            420                 425                 430         
Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile
        435                 440                 445             
Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val
    450                 455                 460                 
Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp
465                 470                 475                 480 
Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val
                485                 490                 495     
Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala
            500                 505                 510         
Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp
        515                 520                 525             
Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys
    530                 535                 540                 
His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro
545                 550                 555                 560 
Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr
                565                 570                 575     
Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn
            580                 585                 590         
Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr
        595                 600                 605             
Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile
    610                 615                 620                 
His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val
625                 630                 635                 640 
Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp
                645                 650                 655     
Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala
            660                 665                 670         
Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp
        675                 680                 685             
Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro
    690                 695                 700                 
Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly
705                 710                 715                 720 
His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met
                725                 730                 735     
Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys
            740                 745                 750         
Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu
        755                 760                 765             
Ile
    


<210> 43
<211> 3821
<212> DNA
<213> Homo sapiens

<400> 43
tgactgcagc agcagcggca gcgcctcggt tcctgagccc accgcaggct gaaggcattg 60
cgcgtagtcc atgcccgtag aggaagtgtg cagatgggat taacgtccac atggagatat 120
ggaagaggac cggggattgg taccgtaacc atggtcagct ggggtcgttt catctgcctg 180
gtcgtggtca ccatggcaac cttgtccctg gcccggccct ccttcagttt agttgaggat 240
accacattag agccagaaga gccaccaacc aaataccaaa tctctcaacc agaagtgtac 300
gtggctgcgc caggggagtc gctagaggtg cgctgcctgt tgaaagatgc cgccgtgatc 360
agttggacta aggatggggt gcacttgggg cccaacaata ggacagtgct tattggggag 420
tacttgcaga taaagggcgc cacgcctaga gactccggcc tctatgcttg tactgccagt 480
aggactgtag acagtgaaac ttggtacttc atggtgaatg tcacagatgc catctcatcc 540
ggagatgatg aggatgacac cgatggtgcg gaagattttg tcagtgagaa cagtaacaac 600
aagagagcac catactggac caacacagaa aagatggaaa agcggctcca tgctgtgcct 660
gcggccaaca ctgtcaagtt tcgctgccca gccgggggga acccaatgcc aaccatgcgg 720
tggctgaaaa acgggaagga gtttaagcag gagcatcgca ttggaggcta caaggtacga 780
aaccagcact ggagcctcat tatggaaagt gtggtcccat ctgacaaggg aaattatacc 840
tgtgtagtgg agaatgaata cgggtccatc aatcacacgt accacctgga tgttgtggcg 900
cctggaagag aaaaggagat tacagcttcc ccagactacc tggagatagc catttactgc 960
ataggggtct tcttaatcgc ctgtatggtg gtaacagtca tcctgtgccg aatgaagaac 1020
acgaccaaga agccagactt cagcagccag ccggctgtgc acaagctgac caaacgtatc 1080
cccctgcgga gacaggtaac agtttcggct gagtccagct cctccatgaa ctccaacacc 1140
ccgctggtga ggataacaac acgcctctct tcaacggcag acacccccat gctggcaggg 1200
gtctccgagt atgaacttcc agaggaccca aaatgggagt ttccaagaga taagctgaca 1260
ctgggcaagc ccctgggaga aggttgcttt gggcaagtgg tcatggcgga agcagtggga 1320
attgacaaag acaagcccaa ggaggcggtc accgtggccg tgaagatgtt gaaagatgat 1380
gccacagaga aagacctttc tgatctggtg tcagagatgg agatgatgaa gatgattggg 1440
aaacacaaga atatcataaa tcttcttgga gcctgcacac aggatgggcc tctctatgtc 1500
atagttgagt atgcctctaa aggcaacctc cgagaatacc tccgagcccg gaggccaccc 1560
gggatggagt actcctatga cattaaccgt gttcctgagg agcagatgac cttcaaggac 1620
ttggtgtcat gcacctacca gctggccaga ggcatggagt acttggcttc ccaaaaatgt 1680
attcatcgag atttagcagc cagaaatgtt ttggtaacag aaaacaatgt gatgaaaata 1740
gcagactttg gactcgccag agatatcaac aatatagact attacaaaaa gaccaccaat 1800
gggcggcttc cagtcaagtg gatggctcca gaagccctgt ttgatagagt atacactcat 1860
cagagtgatg tctggtcctt cggggtgtta atgtgggaga tcttcacttt agggggctcg 1920
ccctacccag ggattcccgt ggaggaactt tttaagctgc tgaaggaagg acacagaatg 1980
gataagccag ccaactgcac caacgaactg tacatgatga tgagggactg ttggcatgca 2040
gtgccctccc agagaccaac gttcaagcag ttggtagaag acttggatcg aattctcact 2100
ctcacaacca atgaggaata cttggacctc agccaacctc tcgaacagta ttcacctagt 2160
taccctgaca caagaagttc ttgttcttca ggagatgatt ctgttttttc tccagacccc 2220
atgccttacg aaccatgcct tcctcagtat ccacacataa acggcagtgt taaaacatga 2280
atgactgtgt ctgcctgtcc ccaaacagga cagcactggg aacctagcta cactgagcag 2340
ggagaccatg cctcccagag cttgttgtct ccacttgtat atatggatca gaggagtaaa 2400
taattggaaa agtaatcagc atatgtgtaa agatttatac agttgaaaac ttgtaatctt 2460
ccccaggagg agaagaaggt ttctggagca gtggactgcc acaagccacc atgtaacccc 2520
tctcacctgc cgtgcgtact ggctgtggac cagtaggact caaggtggac gtgcgttctg 2580
ccttccttgt taattttgta ataattggag aagatttatg tcagcacaca cttacagagc 2640
acaaatgcag tatataggtg ctggatgtat gtaaatatat tcaaattatg tataaatata 2700
tattatatat ttacaaggag ttattttttg tattgatttt aaatggatgt cccaatgcac 2760
ctagaaaatt ggtctctctt tttttaatag ctatttgcta aatgctgttc ttacacataa 2820
tttcttaatt ttcaccgagc agaggtggaa aaatactttt gctttcaggg aaaatggtat 2880
aacgttaatt tattaataaa ttggtaatat acaaaacaat taatcattta tagttttttt 2940
tgtaatttaa gtggcatttc tatgcaggca gcacagcaga ctagttaatc tattgcttgg 3000
acttaactag ttatcagatc ctttgaaaag agaatattta caatatatga ctaatttggg 3060
gaaaatgaag ttttgattta tttgtgttta aatgctgctg tcagacgatt gttcttagac 3120
ctcctaaatg ccccatatta aaagaactca ttcataggaa ggtgtttcat tttggtgtgc 3180
aaccctgtca ttacgtcaac gcaacgtcta actggacttc ccaagataaa tggtaccagc 3240
gtcctcttaa aagatgcctt aatccattcc ttgaggacag accttagttg aaatgatagc 3300
agaatgtgct tctctctggc agctggcctt ctgcttctga gttgcacatt aatcagatta 3360
gcctgtattc tcttcagtga attttgataa tggcttccag actctttggc gttggagacg 3420
cctgttagga tcttcaagtc ccatcataga aaattgaaac acagagttgt tctgctgata 3480
gttttgggga tacgtccatc tttttaaggg attgctttca tctaattctg gcaggacctc 3540
accaaaagat ccagcctcat acctacatca gacaaaatat cgccgttgtt ccttctgtac 3600
taaagtattg tgttttgctt tggaaacacc cactcacttt gcaatagccg tgcaagatga 3660
atgcagatta cactgatctt atgtgttaca aaattggaga aagtatttaa taaaacctgt 3720
taatttttat actgacaata aaaatgtttc tacagatatt aatgttaaca agacaaaata 3780
aatgtcacgc aacttatttt tttaataaaa aaaaaaaaaa a                     3821

<210> 44
<211> 709
<212> PRT
<213> Homo sapiens

<400> 44
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Ala Pro Gly Arg Glu Lys Glu
                245                 250                 255     
Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly
            260                 265                 270         
Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met
        275                 280                 285             
Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His
    290                 295                 300                 
Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala
305                 310                 315                 320 
Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr
                325                 330                 335     
Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser
            340                 345                 350         
Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys
        355                 360                 365             
Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val
    370                 375                 380                 
Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val
385                 390                 395                 400 
Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu
                405                 410                 415     
Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His
            420                 425                 430         
Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu
        435                 440                 445             
Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu
    450                 455                 460                 
Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg
465                 470                 475                 480 
Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr
                485                 490                 495     
Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His
            500                 505                 510         
Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met
        515                 520                 525             
Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr
    530                 535                 540                 
Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro
545                 550                 555                 560 
Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser
                565                 570                 575     
Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr
            580                 585                 590         
Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His
        595                 600                 605             
Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met
    610                 615                 620                 
Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln
625                 630                 635                 640 
Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu
                645                 650                 655     
Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro
            660                 665                 670         
Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro
        675                 680                 685             
Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn
    690                 695                 700                 
Gly Ser Val Lys Thr
705                 


<210> 45
<211> 3708
<212> DNA
<213> Homo sapiens

<400> 45
aatttgttga ggaatttccc cctagccttg accccttgac agctcccgct cctactcagt 60
gctggggaga agtagggagg ccttaagcga agagatgggt ctgcactttg gaggagccgg 120
acactgttga ctttcctgat gtgaaatcta cccaggaaca aaacaccagt gactgcagca 180
gcagcggcag cgcctcggtt cctgagccca ccgcaggctg aaggcattgc gcgtagtcca 240
tgcccgtaga ggaagtgtgc agatgggatt aacgtccaca tggagatatg gaagaggacc 300
ggggattggt accgtaacca tggtcagctg gggtcgtttc atctgcctgg tcgtggtcac 360
catggcaacc ttgtccctgg cccggccctc cttcagttta gttgaggata ccacattaga 420
gccagaagat gccatctcat ccggagatga tgaggatgac accgatggtg cggaagattt 480
tgtcagtgag aacagtaaca acaagagagc accatactgg accaacacag aaaagatgga 540
aaagcggctc catgctgtgc ctgcggccaa cactgtcaag tttcgctgcc cagccggggg 600
gaacccaatg ccaaccatgc ggtggctgaa aaacgggaag gagtttaagc aggagcatcg 660
cattggaggc tacaaggtac gaaaccagca ctggagcctc attatggaaa gtgtggtccc 720
atctgacaag ggaaattata cctgtgtagt ggagaatgaa tacgggtcca tcaatcacac 780
gtaccacctg gatgttgtgg agcgatcgcc tcaccggccc atcctccaag ccggactgcc 840
ggcaaatgcc tccacagtgg tcggaggaga cgtagagttt gtctgcaagg tttacagtga 900
tgcccagccc cacatccagt ggatcaagca cgtggaaaag aacggcagta aatacgggcc 960
cgacgggctg ccctacctca aggttctcaa ggccgccggt gttaacacca cggacaaaga 1020
gattgaggtt ctctatattc ggaatgtaac ttttgaggac gctggggaat atacgtgctt 1080
ggcgggtaat tctattggga tatcctttca ctctgcatgg ttgacagttc tgccagcgcc 1140
tggaagagaa aaggagatta cagcttcccc agactacctg gagatagcca tttactgcat 1200
aggggtcttc ttaatcgcct gtatggtggt aacagtcatc ctgtgccgaa tgaagaacac 1260
gaccaagaag ccagacttca gcagccagcc ggctgtgcac aagctgacca aacgtatccc 1320
cctgcggaga caggtaacag tttcggctga gtccagctcc tccatgaact ccaacacccc 1380
gctggtgagg ataacaacac gcctctcttc aacggcagac acccccatgc tggcaggggt 1440
ctccgagtat gaacttccag aggacccaaa atgggagttt ccaagagata agctgacact 1500
gggcaagccc ctgggagaag gttgctttgg gcaagtggtc atggcggaag cagtgggaat 1560
tgacaaagac aagcccaagg aggcggtcac cgtggccgtg aagatgttga aagatgatgc 1620
cacagagaaa gacctttctg atctggtgtc agagatggag atgatgaaga tgattgggaa 1680
acacaagaat atcataaatc ttcttggagc ctgcacacag gatgggcctc tctatgtcat 1740
agttgagtat gcctctaaag gcaacctccg agaatacctc cgagcccgga ggccacccgg 1800
gatggagtac tcctatgaca ttaaccgtgt tcctgaggag cagatgacct tcaaggactt 1860
ggtgtcatgc acctaccagc tggccagagg catggagtac ttggcttccc aaaaatgtat 1920
tcatcgagat ttagcagcca gaaatgtttt ggtaacagaa aacaatgtga tgaaaatagc 1980
agactttgga ctcgccagag atatcaacaa tatagactat tacaaaaaga ccaccaatgg 2040
gcggcttcca gtcaagtgga tggctccaga agccctgttt gatagagtat acactcatca 2100
gagtgatgtc tggtccttcg gggtgttaat gtgggagatc ttcactttag ggggctcgcc 2160
ctacccaggg attcccgtgg aggaactttt taagctgctg aaggaaggac acagaatgga 2220
taagccagcc aactgcacca acgaactgta catgatgatg agggactgtt ggcatgcagt 2280
gccctcccag agaccaacgt tcaagcagtt ggtagaagac ttggatcgaa ttctcactct 2340
cacaaccaat gaggaggaga agaaggtttc tggagcagtg gactgccaca agccaccatg 2400
taacccctct cacctgccgt gcgtactggc tgtggaccag taggactcaa ggtggacgtg 2460
cgttctgcct tccttgttaa ttttgtaata attggagaag atttatgtca gcacacactt 2520
acagagcaca aatgcagtat ataggtgctg gatgtatgta aatatattca aattatgtat 2580
aaatatatat tatatattta caaggagtta ttttttgtat tgattttaaa tggatgtccc 2640
aatgcaccta gaaaattggt ctctcttttt ttaatagcta tttgctaaat gctgttctta 2700
cacataattt cttaattttc accgagcaga ggtggaaaaa tacttttgct ttcagggaaa 2760
atggtataac gttaatttat taataaattg gtaatataca aaacaattaa tcatttatag 2820
ttttttttgt aatttaagtg gcatttctat gcaggcagca cagcagacta gttaatctat 2880
tgcttggact taactagtta tcagatcctt tgaaaagaga atatttacaa tatatgacta 2940
atttggggaa aatgaagttt tgatttattt gtgtttaaat gctgctgtca gacgattgtt 3000
cttagacctc ctaaatgccc catattaaaa gaactcattc ataggaaggt gtttcatttt 3060
ggtgtgcaac cctgtcatta cgtcaacgca acgtctaact ggacttccca agataaatgg 3120
taccagcgtc ctcttaaaag atgccttaat ccattccttg aggacagacc ttagttgaaa 3180
tgatagcaga atgtgcttct ctctggcagc tggccttctg cttctgagtt gcacattaat 3240
cagattagcc tgtattctct tcagtgaatt ttgataatgg cttccagact ctttggcgtt 3300
ggagacgcct gttaggatct tcaagtccca tcatagaaaa ttgaaacaca gagttgttct 3360
gctgatagtt ttggggatac gtccatcttt ttaagggatt gctttcatct aattctggca 3420
ggacctcacc aaaagatcca gcctcatacc tacatcagac aaaatatcgc cgttgttcct 3480
tctgtactaa agtattgtgt tttgctttgg aaacacccac tcactttgca atagccgtgc 3540
aagatgaatg cagattacac tgatcttatg tgttacaaaa ttggagaaag tatttaataa 3600
aacctgttaa tttttatact gacaataaaa atgtttctac agatattaat gttaacaaga 3660
caaaataaat gtcacgcaac ttattttttt aataaaaaaa aaaaaaaa              3708

<210> 46
<211> 707
<212> PRT
<213> Homo sapiens

<400> 46
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Thr
        35                  40                  45              
Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn Lys Arg Ala
    50                  55                  60                  
Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val
65                  70                  75                  80  
Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro
                85                  90                  95      
Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu
            100                 105                 110         
His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile
        115                 120                 125             
Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val
    130                 135                 140                 
Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val
145                 150                 155                 160 
Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn
                165                 170                 175     
Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr
            180                 185                 190         
Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn
        195                 200                 205             
Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys
    210                 215                 220                 
Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile
225                 230                 235                 240 
Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly
                245                 250                 255     
Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro
            260                 265                 270         
Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu
        275                 280                 285             
Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val Val
    290                 295                 300                 
Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys Lys Pro Asp Phe
305                 310                 315                 320 
Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu Arg
                325                 330                 335     
Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser Asn
            340                 345                 350         
Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr
        355                 360                 365             
Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys
    370                 375                 380                 
Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu
385                 390                 395                 400 
Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val Gly Ile Asp Lys
                405                 410                 415     
Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys Met Leu Lys Asp
            420                 425                 430         
Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met
        435                 440                 445             
Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala
    450                 455                 460                 
Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys
465                 470                 475                 480 
Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met Glu
                485                 490                 495     
Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe Lys
            500                 505                 510         
Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu
        515                 520                 525             
Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu
    530                 535                 540                 
Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg
545                 550                 555                 560 
Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu
                565                 570                 575     
Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr
            580                 585                 590         
His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile Phe
        595                 600                 605             
Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe
    610                 615                 620                 
Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr
625                 630                 635                 640 
Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser
                645                 650                 655     
Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu
            660                 665                 670         
Thr Leu Thr Thr Asn Glu Glu Glu Lys Lys Val Ser Gly Ala Val Asp
        675                 680                 685             
Cys His Lys Pro Pro Cys Asn Pro Ser His Leu Pro Cys Val Leu Ala
    690                 695                 700                 
Val Asp Gln
705         


<210> 47
<211> 4103
<212> DNA
<213> Homo sapiens

<400> 47
gagcacacat tgcctcactg aagtggctgc acgtatctga gtcctgtagc tactgtttta 60
tctctgtttc ttaaaagtat gcttttaaaa agattagcct cacacatttc tgtggaccgg 120
tctggtggta tcacctggga ctctgaggtg aggatggaag gatttagcag ataatgaaaa 180
agaactctgt ttgcgcacat ttgagaggct gaaaaatggt tttatcccac ttgggctgga 240
gtgatttggc attggggaag attccctgac tcgccaatct ctttccttta gtgactgcag 300
cagcagcggc agcgcctcgg ttcctgagcc caccgcaggc tgaaggcatt gcgcgtagtc 360
catgcccgta gaggaagtgt gcagatggga ttaacgtcca catggagata tggaagagga 420
ccggggattg gtaccgtaac catggtcagc tggggtcgtt tcatctgcct ggtcgtggtc 480
accatggcaa ccttgtccct ggcccggccc tccttcagtt tagttgagga taccacatta 540
gagccagaag gagcaccata ctggaccaac acagaaaaga tggaaaagcg gctccatgct 600
gtgcctgcgg ccaacactgt caagtttcgc tgcccagccg gggggaaccc aatgccaacc 660
atgcggtggc tgaaaaacgg gaaggagttt aagcaggagc atcgcattgg aggctacaag 720
gtacgaaacc agcactggag cctcattatg gaaagtgtgg tcccatctga caagggaaat 780
tatacctgtg tagtggagaa tgaatacggg tccatcaatc acacgtacca cctggatgtt 840
gtggagcgat cgcctcaccg gcccatcctc caagccggac tgccggcaaa tgcctccaca 900
gtggtcggag gagacgtaga gtttgtctgc aaggtttaca gtgatgccca gccccacatc 960
cagtggatca agcacgtgga aaagaacggc agtaaatacg ggcccgacgg gctgccctac 1020
ctcaaggttc tcaaggccgc cggtgttaac accacggaca aagagattga ggttctctat 1080
attcggaatg taacttttga ggacgctggg gaatatacgt gcttggcggg taattctatt 1140
gggatatcct ttcactctgc atggttgaca gttctgccag cgcctggaag agaaaaggag 1200
attacagctt ccccagacta cctggagata gccatttact gcataggggt cttcttaatc 1260
gcctgtatgg tggtaacagt catcctgtgc cgaatgaaga acacgaccaa gaagccagac 1320
ttcagcagcc agccggctgt gcacaagctg accaaacgta tccccctgcg gagacaggta 1380
acagtttcgg ctgagtccag ctcctccatg aactccaaca ccccgctggt gaggataaca 1440
acacgcctct cttcaacggc agacaccccc atgctggcag gggtctccga gtatgaactt 1500
ccagaggacc caaaatggga gtttccaaga gataagctga cactgggcaa gcccctggga 1560
gaaggttgct ttgggcaagt ggtcatggcg gaagcagtgg gaattgacaa agacaagccc 1620
aaggaggcgg tcaccgtggc cgtgaagatg ttgaaagatg atgccacaga gaaagacctt 1680
tctgatctgg tgtcagagat ggagatgatg aagatgattg ggaaacacaa gaatatcata 1740
aatcttcttg gagcctgcac acaggatggg cctctctatg tcatagttga gtatgcctct 1800
aaaggcaacc tccgagaata cctccgagcc cggaggccac ccgggatgga gtactcctat 1860
gacattaacc gtgttcctga ggagcagatg accttcaagg acttggtgtc atgcacctac 1920
cagctggcca gaggcatgga gtacttggct tcccaaaaat gtattcatcg agatttagca 1980
gccagaaatg ttttggtaac agaaaacaat gtgatgaaaa tagcagactt tggactcgcc 2040
agagatatca acaatataga ctattacaaa aagaccacca atgggcggct tccagtcaag 2100
tggatggctc cagaagccct gtttgataga gtatacactc atcagagtga tgtctggtcc 2160
ttcggggtgt taatgtggga gatcttcact ttagggggct cgccctaccc agggattccc 2220
gtggaggaac tttttaagct gctgaaggaa ggacacagaa tggataagcc agccaactgc 2280
accaacgaac tgtacatgat gatgagggac tgttggcatg cagtgccctc ccagagacca 2340
acgttcaagc agttggtaga agacttggat cgaattctca ctctcacaac caatgaggaa 2400
tacttggacc tcagccaacc tctcgaacag tattcaccta gttaccctga cacaagaagt 2460
tcttgttctt caggagatga ttctgttttt tctccagacc ccatgcctta cgaaccatgc 2520
cttcctcagt atccacacat aaacggcagt gttaaaacat gaatgactgt gtctgcctgt 2580
ccccaaacag gacagcactg ggaacctagc tacactgagc agggagacca tgcctcccag 2640
agcttgttgt ctccacttgt atatatggat cagaggagta aataattgga aaagtaatca 2700
gcatatgtgt aaagatttat acagttgaaa acttgtaatc ttccccagga ggagaagaag 2760
gtttctggag cagtggactg ccacaagcca ccatgtaacc cctctcacct gccgtgcgta 2820
ctggctgtgg accagtagga ctcaaggtgg acgtgcgttc tgccttcctt gttaattttg 2880
taataattgg agaagattta tgtcagcaca cacttacaga gcacaaatgc agtatatagg 2940
tgctggatgt atgtaaatat attcaaatta tgtataaata tatattatat atttacaagg 3000
agttattttt tgtattgatt ttaaatggat gtcccaatgc acctagaaaa ttggtctctc 3060
tttttttaat agctatttgc taaatgctgt tcttacacat aatttcttaa ttttcaccga 3120
gcagaggtgg aaaaatactt ttgctttcag ggaaaatggt ataacgttaa tttattaata 3180
aattggtaat atacaaaaca attaatcatt tatagttttt tttgtaattt aagtggcatt 3240
tctatgcagg cagcacagca gactagttaa tctattgctt ggacttaact agttatcaga 3300
tcctttgaaa agagaatatt tacaatatat gactaatttg gggaaaatga agttttgatt 3360
tatttgtgtt taaatgctgc tgtcagacga ttgttcttag acctcctaaa tgccccatat 3420
taaaagaact cattcatagg aaggtgtttc attttggtgt gcaaccctgt cattacgtca 3480
acgcaacgtc taactggact tcccaagata aatggtacca gcgtcctctt aaaagatgcc 3540
ttaatccatt ccttgaggac agaccttagt tgaaatgata gcagaatgtg cttctctctg 3600
gcagctggcc ttctgcttct gagttgcaca ttaatcagat tagcctgtat tctcttcagt 3660
gaattttgat aatggcttcc agactctttg gcgttggaga cgcctgttag gatcttcaag 3720
tcccatcata gaaaattgaa acacagagtt gttctgctga tagttttggg gatacgtcca 3780
tctttttaag ggattgcttt catctaattc tggcaggacc tcaccaaaag atccagcctc 3840
atacctacat cagacaaaat atcgccgttg ttccttctgt actaaagtat tgtgttttgc 3900
tttggaaaca cccactcact ttgcaatagc cgtgcaagat gaatgcagat tacactgatc 3960
ttatgtgtta caaaattgga gaaagtattt aataaaacct gttaattttt atactgacaa 4020
taaaaatgtt tctacagata ttaatgttaa caagacaaaa taaatgtcac gcaacttatt 4080
tttttaataa aaaaaaaaaa aaa                                         4103

<210> 48
<211> 706
<212> PRT
<213> Homo sapiens

<400> 48
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Gly Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu
        35                  40                  45              
Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys
    50                  55                  60                  
Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly
65                  70                  75                  80  
Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn
                85                  90                  95      
Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly
            100                 105                 110         
Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr
        115                 120                 125             
Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln
    130                 135                 140                 
Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu
145                 150                 155                 160 
Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile
                165                 170                 175     
Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro
            180                 185                 190         
Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu
        195                 200                 205             
Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu
    210                 215                 220                 
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala
225                 230                 235                 240 
Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala
                245                 250                 255     
Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu
            260                 265                 270         
Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr
        275                 280                 285             
Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr
    290                 295                 300                 
Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser
305                 310                 315                 320 
Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu
                325                 330                 335     
Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu
            340                 345                 350         
Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu
        355                 360                 365             
Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu
    370                 375                 380                 
Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala
385                 390                 395                 400 
Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu
                405                 410                 415     
Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile
            420                 425                 430         
Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile
        435                 440                 445             
Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg
    450                 455                 460                 
Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu
465                 470                 475                 480 
Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala
                485                 490                 495     
Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu
            500                 505                 510         
Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala
        515                 520                 525             
Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys
    530                 535                 540                 
Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu
545                 550                 555                 560 
Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val
                565                 570                 575     
Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile
            580                 585                 590         
Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp
        595                 600                 605             
Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys
    610                 615                 620                 
Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu
625                 630                 635                 640 
Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp
                645                 650                 655     
Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg
            660                 665                 670         
Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met
        675                 680                 685             
Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val
    690                 695                 700                 
Lys Thr
705     


<210> 49
<211> 4306
<212> DNA
<213> Homo sapiens

<400> 49
ggcggcggct ggaggagagc gcggtggaga gccgagcggg cgggcggcgg gtgcggagcg 60
ggcgagggag cgcgcgcggc cgccacaaag ctcgggcgcc gcggggctgc atgcggcgta 120
cctggcccgg cgcggcgact gctctccggg ctggcggggg ccggccgcga gccccggggg 180
ccccgaggcc gcagcttgcc tgcgcgctct gagccttcgc aactcgcgag caaagtttgg 240
tggaggcaac gccaagcctg agtcctttct tcctctcgtt ccccaaatcc gagggcagcc 300
cgcgggcgtc atgcccgcgc tcctccgcag cctggggtac gcgtgaagcc cgggaggctt 360
ggcgccggcg aagacccaag gaccactctt ctgcgtttgg agttgctccc cgcaaccccg 420
ggctcgtcgc tttctccatc ccgacccacg cggggcgcgg ggacaacaca ggtcgcggag 480
gagcgttgcc attcaagtga ctgcagcagc agcggcagcg cctcggttcc tgagcccacc 540
gcaggctgaa ggcattgcgc gtagtccatg cccgtagagg aagtgtgcag atgggattaa 600
cgtccacatg gagatatgga agaggaccgg ggattggtac cgtaaccatg gtcagctggg 660
gtcgtttcat ctgcctggtc gtggtcacca tggcaacctt gtccctggcc cggccctcct 720
tcagtttagt tgaggatacc acattagagc cagaagagcc accaaccaaa taccaaatct 780
ctcaaccaga agtgtacgtg gctgcgccag gggagtcgct agaggtgcgc tgcctgttga 840
aagatgccgc cgtgatcagt tggactaagg atggggtgca cttggggccc aacaatagga 900
cagtgcttat tggggagtac ttgcagataa agggcgccac gcctagagac tccggcctct 960
atgcttgtac tgccagtagg actgtagaca gtgaaacttg gtacttcatg gtgaatgtca 1020
cagatgccat ctcatccgga gatgatgagg atgacaccga tggtgcggaa gattttgtca 1080
gtgagaacag taacaacaag agagcaccat actggaccaa cacagaaaag atggaaaagc 1140
ggctccatgc tgtgcctgcg gccaacactg tcaagtttcg ctgcccagcc ggggggaacc 1200
caatgccaac catgcggtgg ctgaaaaacg ggaaggagtt taagcaggag catcgcattg 1260
gaggctacaa ggtacgaaac cagcactgga gcctcattat ggaaagtgtg gtcccatctg 1320
acaagggaaa ttatacctgt gtagtggaga atgaatacgg gtccatcaat cacacgtacc 1380
acctggatgt tgtggagcga tcgcctcacc ggcccatcct ccaagccgga ctgccggcaa 1440
atgcctccac agtggtcgga ggagacgtag agtttgtctg caaggtttac agtgatgccc 1500
agccccacat ccagtggatc aagcacgtgg aaaagaacgg cagtaaatac gggcccgacg 1560
ggctgcccta cctcaaggtt ctcaaggttt cggctgagtc cagctcctcc atgaactcca 1620
acaccccgct ggtgaggata acaacacgcc tctcttcaac ggcagacacc cccatgctgg 1680
caggggtctc cgagtatgaa cttccagagg acccaaaatg ggagtttcca agagataagc 1740
tgacactggg caagcccctg ggagaaggtt gctttgggca agtggtcatg gcggaagcag 1800
tgggaattga caaagacaag cccaaggagg cggtcaccgt ggccgtgaag atgttgaaag 1860
atgatgccac agagaaagac ctttctgatc tggtgtcaga gatggagatg atgaagatga 1920
ttgggaaaca caagaatatc ataaatcttc ttggagcctg cacacaggat gggcctctct 1980
atgtcatagt tgagtatgcc tctaaaggca acctccgaga atacctccga gcccggaggc 2040
cacccgggat ggagtactcc tatgacatta accgtgttcc tgaggagcag atgaccttca 2100
aggacttggt gtcatgcacc taccagctgg ccagaggcat ggagtacttg gcttcccaaa 2160
aatgtattca tcgagattta gcagccagaa atgttttggt aacagaaaac aatgtgatga 2220
aaatagcaga ctttggactc gccagagata tcaacaatat agactattac aaaaagacca 2280
ccaatgggcg gcttccagtc aagtggatgg ctccagaagc cctgtttgat agagtataca 2340
ctcatcagag tgatgtctgg tccttcgggg tgttaatgtg ggagatcttc actttagggg 2400
gctcgcccta cccagggatt cccgtggagg aactttttaa gctgctgaag gaaggacaca 2460
gaatggataa gccagccaac tgcaccaacg aactgtacat gatgatgagg gactgttggc 2520
atgcagtgcc ctcccagaga ccaacgttca agcagttggt agaagacttg gatcgaattc 2580
tcactctcac aaccaatgag gaatacttgg acctcagcca acctctcgaa cagtattcac 2640
ctagttaccc tgacacaaga agttcttgtt cttcaggaga tgattctgtt ttttctccag 2700
accccatgcc ttacgaacca tgccttcctc agtatccaca cataaacggc agtgttaaaa 2760
catgaatgac tgtgtctgcc tgtccccaaa caggacagca ctgggaacct agctacactg 2820
agcagggaga ccatgcctcc cagagcttgt tgtctccact tgtatatatg gatcagagga 2880
gtaaataatt ggaaaagtaa tcagcatatg tgtaaagatt tatacagttg aaaacttgta 2940
atcttcccca ggaggagaag aaggtttctg gagcagtgga ctgccacaag ccaccatgta 3000
acccctctca cctgccgtgc gtactggctg tggaccagta ggactcaagg tggacgtgcg 3060
ttctgccttc cttgttaatt ttgtaataat tggagaagat ttatgtcagc acacacttac 3120
agagcacaaa tgcagtatat aggtgctgga tgtatgtaaa tatattcaaa ttatgtataa 3180
atatatatta tatatttaca aggagttatt ttttgtattg attttaaatg gatgtcccaa 3240
tgcacctaga aaattggtct ctcttttttt aatagctatt tgctaaatgc tgttcttaca 3300
cataatttct taattttcac cgagcagagg tggaaaaata cttttgcttt cagggaaaat 3360
ggtataacgt taatttatta ataaattggt aatatacaaa acaattaatc atttatagtt 3420
ttttttgtaa tttaagtggc atttctatgc aggcagcaca gcagactagt taatctattg 3480
cttggactta actagttatc agatcctttg aaaagagaat atttacaata tatgactaat 3540
ttggggaaaa tgaagttttg atttatttgt gtttaaatgc tgctgtcaga cgattgttct 3600
tagacctcct aaatgcccca tattaaaaga actcattcat aggaaggtgt ttcattttgg 3660
tgtgcaaccc tgtcattacg tcaacgcaac gtctaactgg acttcccaag ataaatggta 3720
ccagcgtcct cttaaaagat gccttaatcc attccttgag gacagacctt agttgaaatg 3780
atagcagaat gtgcttctct ctggcagctg gccttctgct tctgagttgc acattaatca 3840
gattagcctg tattctcttc agtgaatttt gataatggct tccagactct ttggcgttgg 3900
agacgcctgt taggatcttc aagtcccatc atagaaaatt gaaacacaga gttgttctgc 3960
tgatagtttt ggggatacgt ccatcttttt aagggattgc tttcatctaa ttctggcagg 4020
acctcaccaa aagatccagc ctcataccta catcagacaa aatatcgccg ttgttccttc 4080
tgtactaaag tattgtgttt tgctttggaa acacccactc actttgcaat agccgtgcaa 4140
gatgaatgca gattacactg atcttatgtg ttacaaaatt ggagaaagta tttaataaaa 4200
cctgttaatt tttatactga caataaaaat gtttctacag atattaatgt taacaagaca 4260
aaataaatgt cacgcaactt atttttttaa taaaaaaaaa aaaaaa                4306

<210> 50
<211> 705
<212> PRT
<213> Homo sapiens

<400> 50
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly
            260                 265                 270         
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile
        275                 280                 285             
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys Val Ser Ala Glu Ser Ser Ser
305                 310                 315                 320 
Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser
                325                 330                 335     
Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu
            340                 345                 350         
Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly
        355                 360                 365             
Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala
    370                 375                 380                 
Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val
385                 390                 395                 400 
Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val
                405                 410                 415     
Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile
            420                 425                 430         
Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val
        435                 440                 445             
Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg
    450                 455                 460                 
Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu
465                 470                 475                 480 
Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg
                485                 490                 495     
Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala
            500                 505                 510         
Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp
        515                 520                 525             
Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr
    530                 535                 540                 
Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe
545                 550                 555                 560 
Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu
                565                 570                 575     
Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro
            580                 585                 590         
Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys
        595                 600                 605             
Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp
    610                 615                 620                 
His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp
625                 630                 635                 640 
Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu
                645                 650                 655     
Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser
            660                 665                 670         
Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro
        675                 680                 685             
Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys
    690                 695                 700                 
Thr
705 


<210> 51
<211> 4303
<212> DNA
<213> Homo sapiens

<400> 51
ggcggcggct ggaggagagc gcggtggaga gccgagcggg cgggcggcgg gtgcggagcg 60
ggcgagggag cgcgcgcggc cgccacaaag ctcgggcgcc gcggggctgc atgcggcgta 120
cctggcccgg cgcggcgact gctctccggg ctggcggggg ccggccgcga gccccggggg 180
ccccgaggcc gcagcttgcc tgcgcgctct gagccttcgc aactcgcgag caaagtttgg 240
tggaggcaac gccaagcctg agtcctttct tcctctcgtt ccccaaatcc gagggcagcc 300
cgcgggcgtc atgcccgcgc tcctccgcag cctggggtac gcgtgaagcc cgggaggctt 360
ggcgccggcg aagacccaag gaccactctt ctgcgtttgg agttgctccc cgcaaccccg 420
ggctcgtcgc tttctccatc ccgacccacg cggggcgcgg ggacaacaca ggtcgcggag 480
gagcgttgcc attcaagtga ctgcagcagc agcggcagcg cctcggttcc tgagcccacc 540
gcaggctgaa ggcattgcgc gtagtccatg cccgtagagg aagtgtgcag atgggattaa 600
cgtccacatg gagatatgga agaggaccgg ggattggtac cgtaaccatg gtcagctggg 660
gtcgtttcat ctgcctggtc gtggtcacca tggcaacctt gtccctggcc cggccctcct 720
tcagtttagt tgaggatacc acattagagc cagaaggagc accatactgg accaacacag 780
aaaagatgga aaagcggctc catgctgtgc ctgcggccaa cactgtcaag tttcgctgcc 840
cagccggggg gaacccaatg ccaaccatgc ggtggctgaa aaacgggaag gagtttaagc 900
aggagcatcg cattggaggc tacaaggtac gaaaccagca ctggagcctc attatggaaa 960
gtgtggtccc atctgacaag ggaaattata cctgtgtagt ggagaatgaa tacgggtcca 1020
tcaatcacac gtaccacctg gatgttgtgg agcgatcgcc tcaccggccc atcctccaag 1080
ccggactgcc ggcaaatgcc tccacagtgg tcggaggaga cgtagagttt gtctgcaagg 1140
tttacagtga tgcccagccc cacatccagt ggatcaagca cgtggaaaag aacggcagta 1200
aatacgggcc cgacgggctg ccctacctca aggttctcaa ggccgccggt gttaacacca 1260
cggacaaaga gattgaggtt ctctatattc ggaatgtaac ttttgaggac gctggggaat 1320
atacgtgctt ggcgggtaat tctattggga tatcctttca ctctgcatgg ttgacagttc 1380
tgccagcgcc tggaagagaa aaggagatta cagcttcccc agactacctg gagatagcca 1440
tttactgcat aggggtcttc ttaatcgcct gtatggtggt aacagtcatc ctgtgccgaa 1500
tgaagaacac gaccaagaag ccagacttca gcagccagcc ggctgtgcac aagctgacca 1560
aacgtatccc cctgcggaga caggtttcgg ctgagtccag ctcctccatg aactccaaca 1620
ccccgctggt gaggataaca acacgcctct cttcaacggc agacaccccc atgctggcag 1680
gggtctccga gtatgaactt ccagaggacc caaaatggga gtttccaaga gataagctga 1740
cactgggcaa gcccctggga gaaggttgct ttgggcaagt ggtcatggcg gaagcagtgg 1800
gaattgacaa agacaagccc aaggaggcgg tcaccgtggc cgtgaagatg ttgaaagatg 1860
atgccacaga gaaagacctt tctgatctgg tgtcagagat ggagatgatg aagatgattg 1920
ggaaacacaa gaatatcata aatcttcttg gagcctgcac acaggatggg cctctctatg 1980
tcatagttga gtatgcctct aaaggcaacc tccgagaata cctccgagcc cggaggccac 2040
ccgggatgga gtactcctat gacattaacc gtgttcctga ggagcagatg accttcaagg 2100
acttggtgtc atgcacctac cagctggcca gaggcatgga gtacttggct tcccaaaaat 2160
gtattcatcg agatttagca gccagaaatg ttttggtaac agaaaacaat gtgatgaaaa 2220
tagcagactt tggactcgcc agagatatca acaatataga ctattacaaa aagaccacca 2280
atgggcggct tccagtcaag tggatggctc cagaagccct gtttgataga gtatacactc 2340
atcagagtga tgtctggtcc ttcggggtgt taatgtggga gatcttcact ttagggggct 2400
cgccctaccc agggattccc gtggaggaac tttttaagct gctgaaggaa ggacacagaa 2460
tggataagcc agccaactgc accaacgaac tgtacatgat gatgagggac tgttggcatg 2520
cagtgccctc ccagagacca acgttcaagc agttggtaga agacttggat cgaattctca 2580
ctctcacaac caatgaggaa tacttggacc tcagccaacc tctcgaacag tattcaccta 2640
gttaccctga cacaagaagt tcttgttctt caggagatga ttctgttttt tctccagacc 2700
ccatgcctta cgaaccatgc cttcctcagt atccacacat aaacggcagt gttaaaacat 2760
gaatgactgt gtctgcctgt ccccaaacag gacagcactg ggaacctagc tacactgagc 2820
agggagacca tgcctcccag agcttgttgt ctccacttgt atatatggat cagaggagta 2880
aataattgga aaagtaatca gcatatgtgt aaagatttat acagttgaaa acttgtaatc 2940
ttccccagga ggagaagaag gtttctggag cagtggactg ccacaagcca ccatgtaacc 3000
cctctcacct gccgtgcgta ctggctgtgg accagtagga ctcaaggtgg acgtgcgttc 3060
tgccttcctt gttaattttg taataattgg agaagattta tgtcagcaca cacttacaga 3120
gcacaaatgc agtatatagg tgctggatgt atgtaaatat attcaaatta tgtataaata 3180
tatattatat atttacaagg agttattttt tgtattgatt ttaaatggat gtcccaatgc 3240
acctagaaaa ttggtctctc tttttttaat agctatttgc taaatgctgt tcttacacat 3300
aatttcttaa ttttcaccga gcagaggtgg aaaaatactt ttgctttcag ggaaaatggt 3360
ataacgttaa tttattaata aattggtaat atacaaaaca attaatcatt tatagttttt 3420
tttgtaattt aagtggcatt tctatgcagg cagcacagca gactagttaa tctattgctt 3480
ggacttaact agttatcaga tcctttgaaa agagaatatt tacaatatat gactaatttg 3540
gggaaaatga agttttgatt tatttgtgtt taaatgctgc tgtcagacga ttgttcttag 3600
acctcctaaa tgccccatat taaaagaact cattcatagg aaggtgtttc attttggtgt 3660
gcaaccctgt cattacgtca acgcaacgtc taactggact tcccaagata aatggtacca 3720
gcgtcctctt aaaagatgcc ttaatccatt ccttgaggac agaccttagt tgaaatgata 3780
gcagaatgtg cttctctctg gcagctggcc ttctgcttct gagttgcaca ttaatcagat 3840
tagcctgtat tctcttcagt gaattttgat aatggcttcc agactctttg gcgttggaga 3900
cgcctgttag gatcttcaag tcccatcata gaaaattgaa acacagagtt gttctgctga 3960
tagttttggg gatacgtcca tctttttaag ggattgcttt catctaattc tggcaggacc 4020
tcaccaaaag atccagcctc atacctacat cagacaaaat atcgccgttg ttccttctgt 4080
actaaagtat tgtgttttgc tttggaaaca cccactcact ttgcaatagc cgtgcaagat 4140
gaatgcagat tacactgatc ttatgtgtta caaaattgga gaaagtattt aataaaacct 4200
gttaattttt atactgacaa taaaaatgtt tctacagata ttaatgttaa caagacaaaa 4260
taaatgtcac gcaacttatt tttttaataa aaaaaaaaaa aaa                   4303

<210> 52
<211> 704
<212> PRT
<213> Homo sapiens

<400> 52
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Gly Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu
        35                  40                  45              
Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys
    50                  55                  60                  
Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly
65                  70                  75                  80  
Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn
                85                  90                  95      
Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly
            100                 105                 110         
Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr
        115                 120                 125             
Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln
    130                 135                 140                 
Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu
145                 150                 155                 160 
Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile
                165                 170                 175     
Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro
            180                 185                 190         
Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu
        195                 200                 205             
Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu
    210                 215                 220                 
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala
225                 230                 235                 240 
Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala
                245                 250                 255     
Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu
            260                 265                 270         
Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr
        275                 280                 285             
Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr
    290                 295                 300                 
Lys Arg Ile Pro Leu Arg Arg Gln Val Ser Ala Glu Ser Ser Ser Ser
305                 310                 315                 320 
Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser
                325                 330                 335     
Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro
            340                 345                 350         
Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys
        355                 360                 365             
Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val
    370                 375                 380                 
Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys
385                 390                 395                 400 
Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser
                405                 410                 415     
Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn
            420                 425                 430         
Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu
        435                 440                 445             
Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro
    450                 455                 460                 
Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln
465                 470                 475                 480 
Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly
                485                 490                 495     
Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala
            500                 505                 510         
Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe
        515                 520                 525             
Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr
    530                 535                 540                 
Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp
545                 550                 555                 560 
Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met
                565                 570                 575     
Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val
            580                 585                 590         
Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro
        595                 600                 605             
Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His
    610                 615                 620                 
Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu
625                 630                 635                 640 
Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu Ser
                645                 650                 655     
Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser Ser
            660                 665                 670         
Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro Tyr
        675                 680                 685             
Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys Thr
    690                 695                 700                 


<210> 53
<211> 3011
<212> DNA
<213> Homo sapiens

<400> 53
ggcggcggct ggaggagagc gcggtggaga gccgagcggg cgggcggcgg gtgcggagcg 60
ggcgagggag cgcgcgcggc cgccacaaag ctcgggcgcc gcggggctgc atgcggcgta 120
cctggcccgg cgcggcgact gctctccggg ctggcggggg ccggccgcga gccccggggg 180
ccccgaggcc gcagcttgcc tgcgcgctct gagccttcgc aactcgcgag caaagtttgg 240
tggaggcaac gccaagcctg agtcctttct tcctctcgtt ccccaaatcc gagggcagcc 300
cgcgggcgtc atgcccgcgc tcctccgcag cctggggtac gcgtgaagcc cgggaggctt 360
ggcgccggcg aagacccaag gaccactctt ctgcgtttgg agttgctccc cgcaaccccg 420
ggctcgtcgc tttctccatc ccgacccacg cggggcgcgg ggacaacaca ggtcgcggag 480
gagcgttgcc attcaagtga ctgcagcagc agcggcagcg cctcggttcc tgagcccacc 540
gcaggctgaa ggcattgcgc gtagtccatg cccgtagagg aagtgtgcag atgggattaa 600
cgtccacatg gagatatgga agaggaccgg ggattggtac cgtaaccatg gtcagctggg 660
gtcgtttcat ctgcctggtc gtggtcacca tggcaacctt gtccctggcc cggccctcct 720
tcagtttagt tgaggatacc acattagagc cagaagatgc catctcatcc ggagatgatg 780
aggatgacac cgatggtgcg gaagattttg tcagtgagaa cagtaacaac aagagagcac 840
catactggac caacacagaa aagatggaaa agcggctcca tgctgtgcct gcggccaaca 900
ctgtcaagtt tcgctgccca gccgggggga acccaatgcc aaccatgcgg tggctgaaaa 960
acgggaagga gtttaagcag gagcatcgca ttggaggcta caaggtacga aaccagcact 1020
ggagcctcat tatggaaagt gtggtcccat ctgacaaggg aaattatacc tgtgtagtgg 1080
agaatgaata cgggtccatc aatcacacgt accacctgga tgttgtggag cgatcgcctc 1140
accggcccat cctccaagcc ggactgccgg caaatgcctc cacagtggtc ggaggagacg 1200
tagagtttgt ctgcaaggtt tacagtgatg cccagcccca catccagtgg atcaagcacg 1260
tggaaaagaa cggcagtaaa tacgggcccg acgggctgcc ctacctcaag gttctcaagc 1320
actcggggat aaatagttcc aatgcagaag tgctggctct gttcaatgtg accgaggcgg 1380
atgctgggga atatatatgt aaggtctcca attatatagg gcaggccaac cagtctgcct 1440
ggctcactgt cctgccaaaa cagcaagcgc ctggaagaga aaaggagatt acagcttccc 1500
cagactacct ggagatagcc atttactgca taggggtctt cttaatcgcc tgtatggtgg 1560
taacagtcat cctgtgccga atgaagaaca cgaccaagaa gccagacttc agcagccagc 1620
cggctgtgca caagctgacc aaacgtatcc ccctgcggag acaggtaaca gtttcggctg 1680
agtccagctc ctccatgaac tccaacaccc cgctggtgag gataacaaca cgcctctctt 1740
caacggcaga cacccccatg ctggcagggg tctccgagta tgaacttcca gaggacccaa 1800
aatgggagtt tccaagagat aagctgacac tgggcaagcc cctgggagaa ggttgctttg 1860
ggcaagtggt catggcggaa gcagtgggaa ttgacaaaga caagcccaag gaggcggtca 1920
ccgtggccgt gaagatgttg aaagatgatg ccacagagaa agacctttct gatctggtgt 1980
cagagatgga gatgatgaag atgattggga aacacaagaa tatcataaat cttcttggag 2040
cctgcacaca ggatgggcct ctctatgtca tagttgagta tgcctctaaa ggcaacctcc 2100
gagaatacct ccgagcccgg aggccacccg ggatggagta ctcctatgac attaaccgtg 2160
ttcctgagga gcagatgacc ttcaaggact tggtgtcatg cacctaccag ctggccagag 2220
gcatggagta cttggcttcc caaaaatgta ttcatcgaga tttagcagcc agaaatgttt 2280
tggtaacaga aaacaatgtg atgaaaatag cagactttgg actcgccaga gatatcaaca 2340
atatagacta ttacaaaaag accaccaatg ggcggcttcc agtcaagtgg atggctccag 2400
aagccctgtt tgatagagta tacactcatc agagtgatgt ctggtccttc ggggtgttaa 2460
tgtgggagat cttcacttta gggggctcgc cctacccagg gattcccgtg gaggaacttt 2520
ttaagctgct gaaggaagga cacagaatgg ataagccagc caactgcacc aacgaactgt 2580
acatgatgat gagggactgt tggcatgcag tgccctccca gagaccaacg ttcaagcagt 2640
tggtagaaga cttggatcga attctcactc tcacaaccaa tgagatctga aagtttatgg 2700
cttcattgag aaactgggaa aagttggtca ggcgcagtgg ctcatgcctg taatcccagc 2760
actttgggag gccgaggcag gcggatcatg aggtcaggag ttccagacca gcctggccaa 2820
catggtgaaa ccctgtctct actaaagata caaaaaatta gccgggcgtg ttggtgtgca 2880
cctgtaatcc cagctactcc gggaggctga ggcaggagag tcacttgaac cggggaggcg 2940
gaggttgcag tgagccgaga tcatgccatt gcattccagc cttggcgaca gagcgagact 3000
ccgtctcaaa a                                                      3011

<210> 54
<211> 680
<212> PRT
<213> Homo sapiens

<400> 54
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Thr
        35                  40                  45              
Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn Lys Arg Ala
    50                  55                  60                  
Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val
65                  70                  75                  80  
Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro
                85                  90                  95      
Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu
            100                 105                 110         
His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile
        115                 120                 125             
Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val
    130                 135                 140                 
Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val
145                 150                 155                 160 
Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn
                165                 170                 175     
Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr
            180                 185                 190         
Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn
        195                 200                 205             
Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys
    210                 215                 220                 
His Ser Gly Ile Asn Ser Ser Asn Ala Glu Val Leu Ala Leu Phe Asn
225                 230                 235                 240 
Val Thr Glu Ala Asp Ala Gly Glu Tyr Ile Cys Lys Val Ser Asn Tyr
                245                 250                 255     
Ile Gly Gln Ala Asn Gln Ser Ala Trp Leu Thr Val Leu Pro Lys Gln
            260                 265                 270         
Gln Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu
        275                 280                 285             
Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val
    290                 295                 300                 
Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys Lys Pro Asp
305                 310                 315                 320 
Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu
                325                 330                 335     
Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser
            340                 345                 350         
Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp
        355                 360                 365             
Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro
    370                 375                 380                 
Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly
385                 390                 395                 400 
Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val Gly Ile Asp
                405                 410                 415     
Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys Met Leu Lys
            420                 425                 430         
Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu
        435                 440                 445             
Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly
    450                 455                 460                 
Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser
465                 470                 475                 480 
Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met
                485                 490                 495     
Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe
            500                 505                 510         
Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr
        515                 520                 525             
Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val
    530                 535                 540                 
Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala
545                 550                 555                 560 
Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg
                565                 570                 575     
Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr
            580                 585                 590         
Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile
        595                 600                 605             
Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu
    610                 615                 620                 
Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys
625                 630                 635                 640 
Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro
                645                 650                 655     
Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile
            660                 665                 670         
Leu Thr Leu Thr Thr Asn Glu Ile
        675                 680 


<210> 55
<211> 396
<212> PRT
<213> Homo sapiens

<400> 55
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Thr Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly
            260                 265                 270         
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile
        275                 280                 285             
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr
305                 310                 315                 320 
Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp
                325                 330                 335     
Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe
            340                 345                 350         
His Ser Ala Trp Leu Thr Val Leu Pro Gly Ile Tyr Cys Ser Phe Ser
        355                 360                 365             
Leu Gly Phe Phe Pro Phe Ser Trp Leu Thr Ala Ile Lys Leu Thr Gln
    370                 375                 380                 
Leu Leu Leu Ser Glu Met Ala Pro Phe Ile Leu Ala
385                 390                 395     


<210> 56
<211> 317
<212> PRT
<213> Homo sapiens

<400> 56
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly
            260                 265                 270         
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile
        275                 280                 285             
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys Val Arg Thr Phe
305                 310                 315         


<210> 57
<211> 266
<212> PRT
<213> Homo sapiens

<400> 57
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Gly Glu Ser Ala Ser Pro Arg
                245                 250                 255     
Val Ala Ala Ala Tyr Gln Pro Ile Leu Ala
            260                 265     

