                         SEQUENCE LISTING

<110>  SAN DIEGO STATE UNIVERSITY FOUNDATION
 
<120>  COMPOSITIONS AND METHODS FOR KINASE-MEDIATED CYTOPROTECTION AND 
       ENHANCED CELLULAR ENGRAFTMENT AND PERSISTENCE

<130>  00038-008WO1/SussmanM2

<140>  not yet assigned
<141>  2010-05-18

<150>  US 61/179,578
<151>  2009-05-19

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Leu Ser Lys Ile Asn Ser Leu Ala His Leu Arg Ala Ala Pro 
1               5                   10                  15      


Cys Asn Asp Leu His Ala Thr Lys Leu Ala Pro Gly Lys Glu Lys Glu 
            20                  25                  30          


Pro Leu Glu Ser Gln Tyr Gln Val Gly Pro Leu Leu Gly Ser Gly Gly 
        35                  40                  45              


Phe Gly Ser Val Tyr Ser Gly Ile Arg Val Ser Asp Asn Leu Pro Val 
    50                  55                  60                  


Ala Ile Lys His Val Glu Lys Asp Arg Ile Ser Asp Trp Gly Glu Leu 
65                  70                  75                  80  


Pro Asn Gly Thr Arg Val Pro Met Glu Val Val Leu Leu Lys Lys Val 
                85                  90                  95      


Ser Ser Gly Phe Ser Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Arg 
            100                 105                 110         


Pro Asp Ser Phe Val Leu Ile Leu Glu Arg Pro Glu Pro Val Gln Asp 
        115                 120                 125             


Leu Phe Asp Phe Ile Thr Glu Arg Gly Ala Leu Gln Glu Glu Leu Ala 
    130                 135                 140                 


Arg Ser Phe Phe Trp Gln Val Leu Glu Ala Val Arg His Cys His Asn 
145                 150                 155                 160 


Cys Gly Val Leu His Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp 
                165                 170                 175     


Leu Asn Arg Gly Glu Leu Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu 
            180                 185                 190         


Leu Lys Asp Thr Val Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser 
        195                 200                 205             


Pro Pro Glu Trp Ile Arg Tyr His Arg Tyr His Gly Arg Ser Ala Ala 
    210                 215                 220                 


Val Trp Ser Leu Gly Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile 
225                 230                 235                 240 


Pro Phe Glu His Asp Glu Glu Ile Ile Arg Gly Gln Val Phe Phe Arg 
                245                 250                 255     


Gln Arg Val Ser Ser Glu Cys Gln His Leu Ile Arg Trp Cys Leu Ala 
            260                 265                 270         


Leu Arg Pro Ser Asp Arg Pro Thr Phe Glu Glu Ile Gln Asn His Pro 
        275                 280                 285             


Trp Met Gln Asp Val Leu Leu Pro Gln Glu Thr Ala Glu Ile His Leu 
    290                 295                 300                 


His Ser Leu Ser Pro Gly Pro Ser Lys 
305                 310             


<210>  2
<211>  404
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (214)..(214)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Met Pro His Glu Pro His Glu Pro Leu Thr Pro Pro Phe Ser Ala Leu 
1               5                   10                  15      


Pro Asp Pro Ala Gly Ala Pro Ser Arg Arg Gln Ser Arg Gln Arg Pro 
            20                  25                  30          


Gln Leu Ser Ser Asp Ser Pro Ser Ala Phe Arg Ala Ser Arg Ser His 
        35                  40                  45              


Ser Arg Asn Ala Thr Arg Ser His Ser His Ser His Ser Pro Arg His 
    50                  55                  60                  


Ser Leu Arg His Ser Pro Gly Ser Gly Ser Cys Gly Ser Ser Ser Gly 
65                  70                  75                  80  


His Arg Pro Cys Ala Asp Ile Leu Glu Val Gly Met Leu Leu Ser Lys 
                85                  90                  95      


Ile Asn Ser Leu Ala His Leu Arg Ala Ala Pro Cys Asn Asp Leu His 
            100                 105                 110         


Ala Thr Lys Leu Ala Pro Gly Lys Glu Lys Glu Pro Leu Glu Ser Gln 
        115                 120                 125             


Tyr Gln Val Gly Pro Leu Leu Gly Ser Gly Gly Phe Gly Ser Val Tyr 
    130                 135                 140                 


Ser Gly Ile Arg Val Ser Asp Asn Leu Pro Val Ala Ile Lys His Val 
145                 150                 155                 160 


Glu Lys Asp Arg Ile Ser Asp Trp Gly Glu Leu Pro Asn Gly Thr Arg 
                165                 170                 175     


Val Pro Met Glu Val Val Leu Leu Lys Lys Val Ser Ser Gly Phe Ser 
            180                 185                 190         


Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Arg Pro Asp Ser Phe Val 
        195                 200                 205             


Leu Ile Leu Glu Arg Xaa Glu Pro Val Gln Asp Leu Phe Asp Phe Ile 
    210                 215                 220                 


Thr Glu Arg Gly Ala Leu Gln Glu Glu Leu Ala Arg Ser Phe Phe Trp 
225                 230                 235                 240 


Gln Val Leu Glu Ala Val Arg His Cys His Asn Cys Gly Val Leu His 
                245                 250                 255     


Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp Leu Asn Arg Gly Glu 
            260                 265                 270         


Leu Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu Leu Lys Asp Thr Val 
        275                 280                 285             


Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser Pro Pro Glu Trp Ile 
    290                 295                 300                 


Arg Tyr His Arg Tyr His Gly Arg Ser Ala Ala Val Trp Ser Leu Gly 
305                 310                 315                 320 


Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile Pro Phe Glu His Asp 
                325                 330                 335     


Glu Glu Ile Ile Arg Gly Gln Val Phe Phe Arg Gln Arg Val Ser Ser 
            340                 345                 350         


Glu Cys Gln His Leu Ile Arg Trp Cys Leu Ala Leu Arg Pro Ser Asp 
        355                 360                 365             


Arg Pro Thr Phe Glu Glu Ile Gln Asn His Pro Trp Met Gln Asp Val 
    370                 375                 380                 


Leu Leu Pro Gln Glu Thr Ala Glu Ile His Leu His Ser Leu Ser Pro 
385                 390                 395                 400 


Gly Pro Ser Lys 
                


<210>  3
<211>  5826
<212>  DNA
<213>  Homo sapiens

<400>  3
cgcgcgcggc gaatctcaac gctgcgccgt ctgcgggcgc ttccgggcca ccagtttctc       60

tgctttccac cctggcgccc cccagccctg gctccccagc tgcgctgccc cgggcgtcca      120

cgccctgcgg gcttagcggg ttcagtgggc tcaatctgcg cagcgccacc tccatgttga      180

ccaagcctct acaggggcct cccgcgcccc ccgggacccc cacgccgccg ccaggtgagt      240

acatcctccc ctactgcaac cagacggggt gggctggaat gatgggttgc agcgcggggg      300

gagggagtcg tggctgggct cagcacgccg ccaccctgac ttcctcgcct ccgcctgcgt      360

aggaggcaag gatcgggaag cgttcgaggc cgagtatcga ctcggccccc tcctgggtaa      420

ggggggcttt ggcaccgtct tcgcaggaca ccgcctcaca gatcgactcc aggtatccgt      480

catgagggtc ttgggagggt caggtgcgtg tggcgggggc gggggtcctg gccctggaat      540

gctggttgac cgaggagtga gcctgcagag tgtgtagagg accaggtgtg tgtgtgtgtg      600

tgtccgtgtc cgtgtccgag gagtgagcct gcagtgtgtg tagagggcca ggtgtgtgtg      660

cgtgcgcgtg tgtgtgtcgg tctaggaggt tatgggcggg gggggggggc agggggcttc      720

agattccgga gttccttgac cccggggtcc aggctgtgta tgtgtgggaa agcagggacc      780

tagatgtgag atttgtggga cttttggagg taggtgtcca gtgtggagtc atgcggacca      840

ggaccctggt acagagttgg ggtgtcgtag agctaaatag gaagattgtg ggcctggggt      900

atcaggaaat ctagaactca ggacttggag tgatgagtcc tgatgcctga gaacggagag      960

cccagggcta aggaaggtgg gagagataaa cttggttccg aggacctgga gggcagggga     1020

gacgccctgg tacgcgttct gtggggtgct gtggttgggg accagaaaga ctagagtgct     1080

ggtagatgga ggaatactgg aggtaggcag aaggtctaga ctgggagggg tctggggatc     1140

acctgctggc ctccttatca cggccttctt ctccaggtgg ccatcaaagt gattccccgg     1200

aatcgtgtgc tgggctggtc ccccttggtg agtaccttcg gagcccttcc taacctacct     1260

actccatcac tgatgtattc acctccttgc ttttccaggg gatgtatgac tccctgggcc     1320

ctgtaacagt gagaatactg ccagtccatt tatactccct tggggtgaca tacagttctg     1380

attcacccca attcccctag agccctggat tctcccctcc aacaaacctt taccatcctt     1440

cctccaaaca ctgctggggg actgcccgca gggcgtgctg gtggggaaca aggggcagag     1500

gtcactggtt gccatggtga tggtggctgc ttctctcttg ccgttataac gctaacggac     1560

atcagggcgg gtctgggcaa gttgtagagt tgggagcgcc ccctggcggg ctctagggga     1620

aactgcgcct gcgcagtcca tgggacccaa agggagaggg tgcgcctgcg caatatcggt     1680

atttttgcat ctcggtgaga aaacgtctgc tgccgtgcaa gtcagcagcc tggccaggag     1740

agggctctac ctcatcccag aaggttgctg ctcgaagtgt acctgcgcag ggcttgggga     1800

ggcagtgggg ggcggatttt gtggccccca gcgtttatac tttttttttt ttggagacac     1860

agtctccctc tgttgcccag gctggagtga ggtgacgcga tctcggctca ctgcaacctc     1920

cgtctcctgg gttcaagtga ttctcctgcc tcagcctccc aagtagctgg gactacagga     1980

gcgcacaacc atgcccggct aatttttgta tttttagtag agacagggtt tcaccatgtt     2040

ggccaggcgg gttttgaact gctgacctca ggtgatccgc ctgcctcggc cactcaaagt     2100

gctgggatta caggcatgag ccaccacgcc cggctgcatt tatgactttt ttttttcctt     2160

gagacggagt ttcgctctgc tgcctgggct ggagtgcagt ggcgtgatct cagctcactg     2220

cagcctccac ctcctgggtt caagcgattc tcctgcctca ggctcctgag tagctggaat     2280

tacaggcacc cgctgccatg cccggctaag ttttacgttt ttagtagaga ccgtgtttca     2340

ccatgttggc caggctggtc tcgaacccct gacctagtga tctgcccgcc ttgggcctcc     2400

caaagtgctg ggattacagg cgtgagccac cgcgcccagc ctctaatttt gtatttttag     2460

tagagacggg gtttctccat gttggtcagg ctggtctcga actcccgacc tcaggtgatc     2520

tgcccgtctc ggcctcccaa agtgctggga ttacaggcgt gagccactgc gcagggccac     2580

atttaggctt tttattggct ggttctaggt gcttggtgat gctgacaaaa cacatgataa     2640

cactaagtcc ttttgtgcta ggtcctttgt aataaatcac tcagctgttt aacaaattag     2700

gtatattgac cacctactat atgacagaca taattctaga cactcagcaa agtattacat     2760

aagtattgag agctcatttt gtgctaggtc cttttttact aattgttttc acctgtttaa     2820

caaatattta ttcagcccta ctctgttagc agccactgtt ctagtgcttc atatacgtcc     2880

gtgaacaaaa caaaccatta cacaataagt gtttattgag tgctaactgc ttgtcagagc     2940

ccatgctatt aagtgctgtc atctgtttaa catttattga tcacctgtgt aaggtactat     3000

tctaatctgg gatatgtcag ggaacaaaac aaaacacata atggtggtgc tgcttctgct     3060

gaaagccttc agttgataac cagatttttc tttgtatttt tgcttgtttg ttttgagaca     3120

gctggagtgc agtggtgtga tcttcactgc aacctctgcc ttcttggctc aagcgaccct     3180

cccacctgag cctcccaagt agctgggact acaggtgcat gccaccaagc ctggctaatt     3240

tttgtgtttg tgccattttg cccaggctga tcttgaactc ttgggctcaa gcaatccacc     3300

cacatcagcc tcccaaagtg ctgggattgc agggatgagc cactgtgcct ggccgaactt     3360

ctttcgttta ttcaaatgtt tattgatcta cgacatgcga gatttgtgca ggctctttgc     3420

tggtttcacc ctctcaatcg ctgtgtgagt ttgtgtcttt agggaaagtg aggcccagga     3480

agggaagtga gttgcttagc gacacactgt caggaaaagg ggccctgagt tgagcttagg     3540

taaaaagcct cagagctgtt gccctgacat ctgtcttttt tctctccctg cttcccaccc     3600

cacctgtgcc cccagtcaga ctcagtcaca tgcccactcg aagtcgcact gctatggaaa     3660

gtgggtgcag gtggtgggca ccctggcgtg atccgcctgc ttgactggtt tgagacacag     3720

gagggcttca tgctggtcct cgagcggcct ttgcccgccc aggatctctt tgactatatc     3780

acagagaagg gcccactggg tgaaggccca agccgctgct tctttggcca agtagtggca     3840

gccatccagc actgccattc ccgtggagtt gtccatcgtg acatcaagga tgagaacatc     3900

ctgatagacc tacgccgtgg ctgtgccaaa ctcattgatt ttggttctgg tgccctgctt     3960

catgatgaac cctacactga ctttgatggt aaggcttctc taaatctccc tggagggatt     4020

gtttttactt gatggccttg tgacctttgg cctccagtgg tggggtgtcc tgtaatcctt     4080

gacccatact gcattatata agatgatcga ttgctaatac tggggattct cagccttgcc     4140

ctctgataaa gtccatcttt taatggtgtg ctaaccttat tctgggctcc tattctggtg     4200

aggggatcct gttaccatcc tgagtattct ttctctggta aggggatcct gttacttttc     4260

agtgctttta ttctgttgag gggactctgt tattttagct gctttttatc tagtgagggg     4320

actctgcttt tatcttgagt gctcttaatt gtggtgaggc catccttcct ggagagtttg     4380

gggttggaga agggcatcat gagattgagt tggtctaacc cctggcttgt gtgcagggac     4440

aagggtgtac agccccccag agtggatctc tcgacaccag taccatgcac tcccggccac     4500

tgtctggtca ctgggcatcc tcctctatga catggtgtgt ggggacattc cctttgagag     4560

ggaccaggag attctggaag ctgagctcca cttcccagcc catgtctccc caggtgaggc     4620

ctcactgacc ccagcccaga agactccatc cttctcaggg accagtaccc cctactgact     4680

gctaatcttc cctctctgct tcttggccta cagactgctg tgccctaatc cgccggtgcc     4740

tggcccccaa accttcttcc cgaccctcac tggaagagat cctgctggac ccctggatgc     4800

aaacaccagc cgaggatgta cccctcaacc cctccaaagg aggccctgcc cctttggcct     4860

ggtccttgct accctaagcc tggcctggcc tggcctggcc cccaatggtc agaagagcca     4920

tcccatggcc atgtcacagg gatagatgga catttgttga cttggtttta caggtcatta     4980

ccagtcatta aagtccagta ttactaaggt aagggattga ggatcagggg ttagaagaca     5040

taaaccaagt ctgcccagtt cccttcccaa tcctacaaag gagccttcct cccagaacct     5100

gtggtccctg attctggagg gggaacttct tgcttctcat tttgctaagg aagtttattt     5160

tggtgaagtt gttcccattc tgagccccgg gactcttatt ctgatgatgt gtcaccccac     5220

attggcacct cctactacca ccacacaaac ttagttcata tgctcttact tgggcaaggg     5280

tgctttcctt ccaatacccc agtagctttt attttagtaa agggaccctt tcccctagcc     5340

tagggtccca tattgggtca agctgcttac ctgcctcagc ccaggattct ttattctggg     5400

ggaggtaatg ccctgttgtt accccaaggc ttcttttttt tttttttttt tttgggtgag     5460

gggaccctac tctgttatcc caagtgctct tattctggtg agaagaacct tacttccata     5520

atttgggaag gaatggaaga tggacaccac cggacaccac cagacactag gatgggatgg     5580

atggtttttt gggggatggg ctaggggaaa taaggcttgc tgtttgttct cctggggcgc     5640

tccctccaac ttttgcagat tcttgcaacc tcctcctgag ccgggattgt ccaattacta     5700

aaatgtaaat aatcacgtat tgtggggagg ggagttccaa gtgtgccctc ctctcttctc     5760

ctgcctggat tatttaaaaa gccatgtgtg gaaacccact atttaataaa agtaatagaa     5820

tcagaa                                                                5826


<210>  4
<211>  2795
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (431)..(1372)

<400>  4
ccctttactc ctggctgcgg ggcgagccgg gcgtctgctg cagcggccgc ggtggctgag       60

gaggcccgag aggagtcggt ggcagcggcg gcggcgggac cggcagcagc agcagcagca      120

gcagcagcag caaccactag cctcctgccc cgcggcgctg ccgcacgagc cccacgagcc      180

gctcaccccg ccgttctcag cgctgcccga ccccgctggc gcgccctccc gccgccagtc      240

ccggcagcgc cctcagttgt cctccgactc gccctcggcc ttccgcgcca gccgcagcca      300

cagccgcaac gccacccgca gccacagcca cagccacagc cccaggcata gccttcggca      360

cagccccggc tccggctcct gcggcagctc ctctgggcac cgtccctgcg ccgacatcct      420

ggaggttggg atg ctc ttg tcc aaa atc aac tcg ctt gcc cac ctg cgc         469
           Met Leu Leu Ser Lys Ile Asn Ser Leu Ala His Leu Arg            
           1               5                   10                         

gcc gcg ccc tgc aac gac ctg cac gcc acc aag ctg gcg ccc ggc aag        517
Ala Ala Pro Cys Asn Asp Leu His Ala Thr Lys Leu Ala Pro Gly Lys           
    15                  20                  25                            

gag aag gag ccc ctg gag tcg cag tac cag gtg ggc ccg cta ctg ggc        565
Glu Lys Glu Pro Leu Glu Ser Gln Tyr Gln Val Gly Pro Leu Leu Gly           
30                  35                  40                  45            

agc ggc ggc ttc ggc tcg gtc tac tca ggc atc cgc gtc tcc gac aac        613
Ser Gly Gly Phe Gly Ser Val Tyr Ser Gly Ile Arg Val Ser Asp Asn           
                50                  55                  60                

ttg ccg gtg gcc atc aaa cac gtg gag aag gac cgg att tcc gac tgg        661
Leu Pro Val Ala Ile Lys His Val Glu Lys Asp Arg Ile Ser Asp Trp           
            65                  70                  75                    

gga gag ctg cct aat ggc act cga gtg ccc atg gaa gtg gtc ctg ctg        709
Gly Glu Leu Pro Asn Gly Thr Arg Val Pro Met Glu Val Val Leu Leu           
        80                  85                  90                        

aag aag gtg agc tcg ggt ttc tcc ggc gtc att agg ctc ctg gac tgg        757
Lys Lys Val Ser Ser Gly Phe Ser Gly Val Ile Arg Leu Leu Asp Trp           
    95                  100                 105                           

ttc gag agg ccc gac agt ttc gtc ctg atc ctg gag agg ccc gag ccg        805
Phe Glu Arg Pro Asp Ser Phe Val Leu Ile Leu Glu Arg Pro Glu Pro           
110                 115                 120                 125           

gtg caa gat ctc ttc gac ttc atc acg gaa agg gga gcc ctg caa gag        853
Val Gln Asp Leu Phe Asp Phe Ile Thr Glu Arg Gly Ala Leu Gln Glu           
                130                 135                 140               

gag ctg gcc cgc agc ttc ttc tgg cag gtg ctg gag gcc gtg cgg cac        901
Glu Leu Ala Arg Ser Phe Phe Trp Gln Val Leu Glu Ala Val Arg His           
            145                 150                 155                   

tgc cac aac tgc ggg gtg ctc cac cgc gac atc aag gac gaa aac atc        949
Cys His Asn Cys Gly Val Leu His Arg Asp Ile Lys Asp Glu Asn Ile           
        160                 165                 170                       

ctt atc gac ctc aat cgc ggc gag ctc aag ctc atc gac ttc ggg tcg        997
Leu Ile Asp Leu Asn Arg Gly Glu Leu Lys Leu Ile Asp Phe Gly Ser           
    175                 180                 185                           

ggg gcg ctg ctc aag gac acc gtc tac acg gac ttc gat ggg acc cga       1045
Gly Ala Leu Leu Lys Asp Thr Val Tyr Thr Asp Phe Asp Gly Thr Arg           
190                 195                 200                 205           

gtg tat agc cct cca gag tgg atc cgc tac cat cgc tac cat ggc agg       1093
Val Tyr Ser Pro Pro Glu Trp Ile Arg Tyr His Arg Tyr His Gly Arg           
                210                 215                 220               

tcg gcg gca gtc tgg tcc ctg ggg atc ctg ctg tat gat atg gtg tgt       1141
Ser Ala Ala Val Trp Ser Leu Gly Ile Leu Leu Tyr Asp Met Val Cys           
            225                 230                 235                   

gga gat att cct ttc gag cat gac gaa gag atc atc agg ggc cag gtt       1189
Gly Asp Ile Pro Phe Glu His Asp Glu Glu Ile Ile Arg Gly Gln Val           
        240                 245                 250                       

ttc ttc agg cag agg gtc tct tca gaa tgt cag cat ctc att aga tgg       1237
Phe Phe Arg Gln Arg Val Ser Ser Glu Cys Gln His Leu Ile Arg Trp           
    255                 260                 265                           

tgc ttg gcc ctg aga cca tca gat agg cca acc ttc gaa gaa atc cag       1285
Cys Leu Ala Leu Arg Pro Ser Asp Arg Pro Thr Phe Glu Glu Ile Gln           
270                 275                 280                 285           

aac cat cca tgg atg caa gat gtt ctc ctg ccc cag gaa act gct gag       1333
Asn His Pro Trp Met Gln Asp Val Leu Leu Pro Gln Glu Thr Ala Glu           
                290                 295                 300               

atc cac ctc cac agc ctg tcg ccg ggg ccc agc aaa tag cagcctttct        1382
Ile His Leu His Ser Leu Ser Pro Gly Pro Ser Lys                           
            305                 310                                       

ggcaggtcct cccctctctt gtcagatgcc cgagggaggg gaagcttctg tctccagctt     1442

cccgagtacc agtgacacgt ctcgccaagc aggacagtgc ttgatacagg aacaacattt     1502

acaactcatt ccagatccca ggcccctgga ggctgcctcc caacagtggg gaagagtgac     1562

tctccagggg tcctaggcct caactcctcc catagatact ctcttcttct cataggtgtc     1622

cagcattgct ggactctgaa atatcccggg ggtggggggt gggggtgggt cagaaccctg     1682

ccatggaact gtttccttca tcatgagttc tgctgaatgc cgcgatgggt caggtagggg     1742

ggaaacaggt tgggatggga taggactagc accattttaa gtccctgtca cctcttccga     1802

ctctttctga gtgccttctg tggggactcc ggctgtgctg ggagaaatac ttgaacttgc     1862

ctcttttacc tgctgcttct ccaaaaatct gcctgggttt tgttccctat ttttctctcc     1922

tgtcctccct caccccctcc ttcatatgaa aggtgccatg gaagaggcta cagggccaaa     1982

cgctgagcca cctgcccttt tttctgcctc ctttagtaaa actccgagtg aactggtctt     2042

cctttttggt ttttacttaa ctgtttcaaa gccaagacct cacacacaca aaaaatgcac     2102

aaacaatgca atcaacagaa aagctgtaaa tgtgtgtaca gttggcatgg tagtatacaa     2162

aaagattgta gtggatctaa tttttaagaa attttgcctt taagttattt tacctgtttt     2222

tgtttcttgt tttgaaagat gcgcattcta acctggaggt caatgttatg tatttattta     2282

tttatttatt tggttccctt cctattccaa gcttccatag ctgctgccct agttttcttt     2342

cctcctttcc tcctctgact tggggacctt ttgggggagg gctgcgacgc ttgctctgtt     2402

tgtggggtga cgggactcag gcgggacagt gctgcagctc cctggcttct gtggggcccc     2462

tcacctactt acccaggtgg gtcccggctc tgtgggtgat ggggaggggc attgctgact     2522

gtgtatatag gataattatg aaaagcagtt ctggatggtg tgccttccag atcctctctg     2582

gggctgtgtt ttgagcagca ggtagcctgc tggttttatc tgagtgaaat actgtacagg     2642

ggaataaaag agatcttatt ttttttttta tacttggcgt tttttgaata aaaacctttt     2702

gtcttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2762

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                  2795


<210>  5
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Leu Ser Lys Ile Asn Ser Leu Ala His Leu Arg Ala Ala Pro 
1               5                   10                  15      


Cys Asn Asp Leu His Ala Thr Lys Leu Ala Pro Gly Lys Glu Lys Glu 
            20                  25                  30          


Pro Leu Glu Ser Gln Tyr Gln Val Gly Pro Leu Leu Gly Ser Gly Gly 
        35                  40                  45              


Phe Gly Ser Val Tyr Ser Gly Ile Arg Val Ser Asp Asn Leu Pro Val 
    50                  55                  60                  


Ala Ile Lys His Val Glu Lys Asp Arg Ile Ser Asp Trp Gly Glu Leu 
65                  70                  75                  80  


Pro Asn Gly Thr Arg Val Pro Met Glu Val Val Leu Leu Lys Lys Val 
                85                  90                  95      


Ser Ser Gly Phe Ser Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Arg 
            100                 105                 110         


Pro Asp Ser Phe Val Leu Ile Leu Glu Arg Pro Glu Pro Val Gln Asp 
        115                 120                 125             


Leu Phe Asp Phe Ile Thr Glu Arg Gly Ala Leu Gln Glu Glu Leu Ala 
    130                 135                 140                 


Arg Ser Phe Phe Trp Gln Val Leu Glu Ala Val Arg His Cys His Asn 
145                 150                 155                 160 


Cys Gly Val Leu His Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp 
                165                 170                 175     


Leu Asn Arg Gly Glu Leu Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu 
            180                 185                 190         


Leu Lys Asp Thr Val Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser 
        195                 200                 205             


Pro Pro Glu Trp Ile Arg Tyr His Arg Tyr His Gly Arg Ser Ala Ala 
    210                 215                 220                 


Val Trp Ser Leu Gly Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile 
225                 230                 235                 240 


Pro Phe Glu His Asp Glu Glu Ile Ile Arg Gly Gln Val Phe Phe Arg 
                245                 250                 255     


Gln Arg Val Ser Ser Glu Cys Gln His Leu Ile Arg Trp Cys Leu Ala 
            260                 265                 270         


Leu Arg Pro Ser Asp Arg Pro Thr Phe Glu Glu Ile Gln Asn His Pro 
        275                 280                 285             


Trp Met Gln Asp Val Leu Leu Pro Gln Glu Thr Ala Glu Ile His Leu 
    290                 295                 300                 


His Ser Leu Ser Pro Gly Pro Ser Lys 
305                 310             


<210>  6
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Leu Ser Lys Phe Gly Ser Leu Ala His Leu Cys Gly Pro Gly 
1               5                   10                  15      


Gly Val Asp His Leu Pro Val Lys Ile Leu Gln Pro Ala Lys Ala Asp 
            20                  25                  30          


Lys Glu Ser Phe Glu Lys Ala Tyr Gln Val Gly Ala 
        35                  40                  


<210>  7
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  7

Val Leu Gly Ser Gly Gly Phe Gly Thr Val Tyr Ala Gly Ser Arg Ile 
1               5                   10                  15      


Ala Asp Gly Leu Pro Val Ala Val Lys His Val Val Lys Glu Arg Val 
            20                  25                  30          


Thr Glu Trp Gly Ser Leu Gly Gly Ala Thr Val Pro Leu Glu Val Val 
        35                  40                  45              


Leu Leu Arg Lys Val Gly Ala Ala Gly Gly Ala Arg Gly Val Ile Arg 
    50                  55                  60                  


Leu Leu Asp Trp Phe Glu Arg Pro Asp Gly Phe Leu Leu Val Leu Glu 
65                  70                  75                  80  


Arg Pro Glu Pro Ala Gln Asp Leu Phe Asp Phe Ile Thr Glu Arg Gly 
                85                  90                  95      


Ala Leu Asp Glu Pro Leu Ala Arg Arg Phe Phe Ala Gln Val Leu Ala 
            100                 105                 110         


Ala Val Arg His Cys His Ser Cys Gly Val Val His Arg Asp Ile Lys 
        115                 120                 125             


Asp Glu Asn Leu Leu Val Asp Leu Arg Ser Gly Glu Leu Lys Leu Ile 
    130                 135                 140                 


Asp Phe Gly Ser Gly Ala Leu Leu Lys Asp Thr Val Tyr Thr Asp Phe 
145                 150                 155                 160 


Asp Gly Thr Arg Val Tyr Ser Pro Pro Glu Trp Ile Arg Tyr His Arg 
                165                 170                 175     


Tyr His Gly Arg Ser Ala Thr Val Trp Ser Leu Gly Val Leu Leu Tyr 
            180                 185                 190         


Asp Met Val Cys Gly Asp Ile Pro Phe Glu Gln Asp Glu Glu Ile Leu 
        195                 200                 205             


Arg Gly Arg Leu Leu Phe Arg Arg Arg Val Ser Pro Glu Cys Gln Gln 
    210                 215                 220                 


Leu Ile Arg Trp Cys Leu Ser Leu Arg Pro Ser Glu Arg Pro Ser Leu 
225                 230                 235                 240 


Asp Gln Ile Ala Ala His Pro Trp Met Leu Gly Ala Asp Gly Gly Ala 
                245                 250                 255     


Pro Glu Ser Cys Asp Leu Arg Leu Cys Thr Leu Asp Pro Asp Asp Val 
            260                 265                 270         


Ala Ser Thr Thr Ser Ser Ser Glu Ser Leu 
        275                 280         


<210>  8
<211>  2410
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (454)..(1434)

<400>  8
gagagcgtga gcgcggagag cggaccgacg cgacacgccg tgcgcctccg cggctgcgct       60

acgaaaacga gtcccggagc ggccccgcgc ccgccgcacc cggccctcgc ccgcccgaag      120

acaggcgcca agctgccccg ccgtctcccc agctagcgcc cggccgccgc cgcctcgcgg      180

gccccgggcg gaagggggcg gggtcccgat tcgccccgcc cccgcggagg gatacgcggc      240

gccgcggccc aaaacccccg ggcgaggcgg ccggggcggg tgaggcgctc cgcctgctgc      300

gcgtctacgc ggtccccgcg ggccttccgg gcccactgcg ccgcgcggac cgcctcgggc      360

tcggacggcc ggtgtccccg gcgcgccgct cgcccggatc ggccgcggct tcggcgcctg      420

gggctcgggg ctccggggag gccgtcgccc gcg atg ctg ctc tcc aag ttc ggc       474
                                     Met Leu Leu Ser Lys Phe Gly          
                                     1               5                    

tcc ctg gcg cac ctc tgc ggg ccc ggc ggc gtg gac cac ctc ccg gtg        522
Ser Leu Ala His Leu Cys Gly Pro Gly Gly Val Asp His Leu Pro Val           
        10                  15                  20                        

aag atc ctg cag cca gcc aag gcg gac aag gag agc ttc gag aag gcg        570
Lys Ile Leu Gln Pro Ala Lys Ala Asp Lys Glu Ser Phe Glu Lys Ala           
    25                  30                  35                            

tac cag gtg ggc gcc gtg ctg ggt agc ggc ggc ttc ggc acg gtc tac        618
Tyr Gln Val Gly Ala Val Leu Gly Ser Gly Gly Phe Gly Thr Val Tyr           
40                  45                  50                  55            

gcg ggt agc cgc atc gcc gac ggg ctc ccg gtg gct gtg aag cac gtg        666
Ala Gly Ser Arg Ile Ala Asp Gly Leu Pro Val Ala Val Lys His Val           
                60                  65                  70                

gtg aag gag cgg gtg acc gag tgg ggc agc ctg ggc ggc gcg acc gtg        714
Val Lys Glu Arg Val Thr Glu Trp Gly Ser Leu Gly Gly Ala Thr Val           
            75                  80                  85                    

ccc ctg gag gtg gtg ctg ctg cgc aag gtg ggc gcg gcg ggc ggc gcg        762
Pro Leu Glu Val Val Leu Leu Arg Lys Val Gly Ala Ala Gly Gly Ala           
        90                  95                  100                       

cgc ggc gtc atc cgc ctg ctg gac tgg ttc gag cgg ccc gac ggc ttc        810
Arg Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Arg Pro Asp Gly Phe           
    105                 110                 115                           

ctg ctg gtg ctg gag cgg ccc gag ccg gcg cag gac ctc ttc gac ttt        858
Leu Leu Val Leu Glu Arg Pro Glu Pro Ala Gln Asp Leu Phe Asp Phe           
120                 125                 130                 135           

atc acg gag cgc ggc gcc ctg gac gag ccg ctg gcg cgc cgc ttc ttc        906
Ile Thr Glu Arg Gly Ala Leu Asp Glu Pro Leu Ala Arg Arg Phe Phe           
                140                 145                 150               

gcg cag gtg ctg gcc gcc gtg cgc cac tgc cac agc tgc ggg gtc gtg        954
Ala Gln Val Leu Ala Ala Val Arg His Cys His Ser Cys Gly Val Val           
            155                 160                 165                   

cac cgc gac att aag gac gaa aat ctg ctt gtg gac ctg cgc tcc gga       1002
His Arg Asp Ile Lys Asp Glu Asn Leu Leu Val Asp Leu Arg Ser Gly           
        170                 175                 180                       

gag ctc aag ctc atc gac ttc ggt tcg ggt gcg ctg ctc aag gac acg       1050
Glu Leu Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu Leu Lys Asp Thr           
    185                 190                 195                           

gtc tac acc gac ttc gac ggc acc cga gtg tac agc ccc ccg gag tgg       1098
Val Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser Pro Pro Glu Trp           
200                 205                 210                 215           

atc cgc tac cac cgc tac cac ggg cgc tcg gcc acc gtg tgg tcg ctg       1146
Ile Arg Tyr His Arg Tyr His Gly Arg Ser Ala Thr Val Trp Ser Leu           
                220                 225                 230               

ggc gtg ctt ctc tac gat atg gtg tgt ggg gac atc ccc ttc gag cag       1194
Gly Val Leu Leu Tyr Asp Met Val Cys Gly Asp Ile Pro Phe Glu Gln           
            235                 240                 245                   

gac gag gag atc ctc cga ggc cgc ctg ctc ttc cgg agg agg gtc tct       1242
Asp Glu Glu Ile Leu Arg Gly Arg Leu Leu Phe Arg Arg Arg Val Ser           
        250                 255                 260                       

cca gag tgc cag cag ctg atc cgg tgg tgc ctg tcc ctg cgg ccc tca       1290
Pro Glu Cys Gln Gln Leu Ile Arg Trp Cys Leu Ser Leu Arg Pro Ser           
    265                 270                 275                           

gag cgg ccg tcg ctg gat cag att gcg gcc cat ccc tgg atg ctg ggg       1338
Glu Arg Pro Ser Leu Asp Gln Ile Ala Ala His Pro Trp Met Leu Gly           
280                 285                 290                 295           

gct gac ggg ggc gtc ccg gag agc tgt gac ctg cgg ctg tgc acc ctc       1386
Ala Asp Gly Gly Val Pro Glu Ser Cys Asp Leu Arg Leu Cys Thr Leu           
                300                 305                 310               

gac cct gat gac gtg gcc agc acc acg tcc agc agc gag agc ttg tga       1434
Asp Pro Asp Asp Val Ala Ser Thr Thr Ser Ser Ser Glu Ser Leu               
            315                 320                 325                   

ggagctgcac ctgactggga gctaggggac cacctgcctt ggccagacct gggacgcccc     1494

cagaccctga ctttctcctg cgtgggccgt ctcctcctgc ggaagcagtg acctctgacc     1554

cctggtgacc ttcgctttga gtgccttttg aacgctggtc ccgcgggact tggttttctc     1614

aagctctgtc tgtccaaaga cgctccggtc gaggtcccgc ctgccctggg tggatacttg     1674

aaccccagac gcccctctgt gctgctgtgt ccggaggcgg ccttcccatc tgcctgccca     1734

cccggagctc tttccgccgg cgcagggtcc caagcccacc tcccgccctc agtcctgcgg     1794

tgtgcgtctg ggcacgtcct gcacacacaa tgcaagtcct ggcctccgcg cccgcccgcc     1854

cacgcgagcc gtacccgccg ccaactctgt tatttatggt gtgaccccct ggaggtgccc     1914

tcggcccacc ggggctattt attgtttaat ttatttgttg aggttatttc ctctgagcag     1974

tctgcctctc ccaagcccca ggggacagtg gggaggcagg ggagggggtg gctgtggtcc     2034

agggacccca ggccctgatt cctgtgcctg gcgtctgtcc cggccccgcc tgtcagaaga     2094

tgaacatgta tagtggctaa cttaagggga gtgggtgacc ctgacacttc caggcactgt     2154

gcccagggtt tgggttttaa attattgact ttgtacagtc tgcttgtggg ctctgaaagc     2214

tggggtgggg ccagagcctg agcgtttaat ttattcagta cctgtgtttg tgtgaatgcg     2274

gtgtgtgcag gcatcgcaga tgggggttct ttcagttcaa aagtgagatg tctggagatc     2334

atattttttt atacaggtat ttcaattaaa atgtttttgt acataaaaaa aaaaaaaaaa     2394

aaaaaaaaaa aaaaaa                                                     2410


<210>  9
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Leu Leu Ser Lys Phe Gly Ser Leu Ala His Leu Cys Gly Pro Gly 
1               5                   10                  15      


Gly Val Asp His Leu Pro Val Lys Ile Leu Gln Pro Ala Lys Ala Asp 
            20                  25                  30          


Lys Glu Ser Phe Glu Lys Ala Tyr Gln Val Gly Ala Val Leu Gly Ser 
        35                  40                  45              


Gly Gly Phe Gly Thr Val Tyr Ala Gly Ser Arg Ile Ala Asp Gly Leu 
    50                  55                  60                  


Pro Val Ala Val Lys His Val Val Lys Glu Arg Val Thr Glu Trp Gly 
65                  70                  75                  80  


Ser Leu Gly Gly Ala Thr Val Pro Leu Glu Val Val Leu Leu Arg Lys 
                85                  90                  95      


Val Gly Ala Ala Gly Gly Ala Arg Gly Val Ile Arg Leu Leu Asp Trp 
            100                 105                 110         


Phe Glu Arg Pro Asp Gly Phe Leu Leu Val Leu Glu Arg Pro Glu Pro 
        115                 120                 125             


Ala Gln Asp Leu Phe Asp Phe Ile Thr Glu Arg Gly Ala Leu Asp Glu 
    130                 135                 140                 


Pro Leu Ala Arg Arg Phe Phe Ala Gln Val Leu Ala Ala Val Arg His 
145                 150                 155                 160 


Cys His Ser Cys Gly Val Val His Arg Asp Ile Lys Asp Glu Asn Leu 
                165                 170                 175     


Leu Val Asp Leu Arg Ser Gly Glu Leu Lys Leu Ile Asp Phe Gly Ser 
            180                 185                 190         


Gly Ala Leu Leu Lys Asp Thr Val Tyr Thr Asp Phe Asp Gly Thr Arg 
        195                 200                 205             


Val Tyr Ser Pro Pro Glu Trp Ile Arg Tyr His Arg Tyr His Gly Arg 
    210                 215                 220                 


Ser Ala Thr Val Trp Ser Leu Gly Val Leu Leu Tyr Asp Met Val Cys 
225                 230                 235                 240 


Gly Asp Ile Pro Phe Glu Gln Asp Glu Glu Ile Leu Arg Gly Arg Leu 
                245                 250                 255     


Leu Phe Arg Arg Arg Val Ser Pro Glu Cys Gln Gln Leu Ile Arg Trp 
            260                 265                 270         


Cys Leu Ser Leu Arg Pro Ser Glu Arg Pro Ser Leu Asp Gln Ile Ala 
        275                 280                 285             


Ala His Pro Trp Met Leu Gly Ala Asp Gly Gly Val Pro Glu Ser Cys 
    290                 295                 300                 


Asp Leu Arg Leu Cys Thr Leu Asp Pro Asp Asp Val Ala Ser Thr Thr 
305                 310                 315                 320 


Ser Ser Ser Glu Ser Leu 
                325     


<210>  10
<211>  992
<212>  DNA
<213>  Homo sapiens

<400>  10
agcttcgaat tatgctcttg tccaaaatca actcgcttgc ccacctgcgc gccgcgccct       60

gcaacgacct gcacgccacc aagctggcgc ccggcaagga gaaggagccc ctggagtcgc      120

agtaccaggt gggcccgcta ctgggcagcg gcggcttcgg ctcggtctac tcaggcatcc      180

gcgtctccga caacttgccg gtggccatca aacacgtgga gaaggaccgg atttccgact      240

ggggagagct gcctaatggc actcgagtgc ccatggaagt ggtcctgctg aagaaggtga      300

gctcgggttt ctccggcgtc attaggctcc tggactggtt cgagaggccc gacagtttcg      360

tcctgatcct ggagaggccc gagccggtgc aagatctctt cgacttcatc acggaaaggg      420

gagccctgca agaggagctg gcccgcagct tcttctggca ggtgctggag gccgtgcggc      480

actgccacaa ctgcggggtg ctccaccgcg acatcaagga cgaaaacatc cttatcgacc      540

tcaatcgcgg cgagctcaag ctcatcgact tcgggtcggg ggcgctgctc aaggacaccg      600

tctacacgga cttcgatggg acccgagtgt atagccctcc agagtggatc cgctaccatc      660

gctaccatgg caggtcggcg gcagtctggt ccctggggat cctgctgtat gatatggtgt      720

gtggagatat tcctttcgag catgacgaag agatcatcag gggccaggtt ttcttcaggc      780

agagggtctc ttcagaatgt cagcatctca ttagatggtg cttggccctg agaccatcag      840

ataggccaac cttcgaagaa atccagaacc atccatggat gcaagatgtt ctcctgcccc      900

aggaaactgc tgagatccac ctccacagcc tgtcgccggg gcccagcagc ctgtcgccgg      960

ggcccagcaa acaattggta ccgcgggccc gg                                    992


<210>  11
<211>  942
<212>  DNA
<213>  Homo sapiens

<400>  11
atgctcttgt ccaaaatcaa ctcgcttgcc cacctgcgcg ccgcgccctg caacgacctg       60

cacgccacca agctggcgcc cggcaaggag aaggagcccc tggagtcgca gtaccaggtg      120

ggcccgctac tgggcagcgg cggcttcggc tcggtctact caggcatccg cgtctccgac      180

aacttgccgg tggccatcaa acacgtggag aaggaccgga tttccgactg gggagagctg      240

cctaatggca ctcgagtgcc catggaagtg gtcctgctga agaaggtgag ctcgggtttc      300

tccggcgtca ttaggctcct ggactggttc gagaggcccg acagtttcgt cctgatcctg      360

gagaggcccg agccggtgca agatctcttc gacttcatca cggaaagggg agccctgcaa      420

gaggagctgg cccgcagctt cttctggcag gtgctggagg ccgtgcggca ctgccacaac      480

tgcggggtgc tccaccgcga catcaaggac gaaaacatcc ttatcgacct caatcgcggc      540

gagctcaagc tcatcgactt cgggtcgggg gcgctgctca aggacaccgt ctacacggac      600

ttcgatggga cccgagtgta tagccctcca gagtggatcc gctaccatcg ctaccatggc      660

aggtcggcgg cagtctggtc cctggggatc ctgctgtatg atatggtgtg tggagatatt      720

cctttcgagc atgacgaaga gatcatcagg ggccaggttt tcttcaggca gagggtctct      780

tcagaatgtc agcatctcat tagatggtgc ttggccctga gaccatcaga taggccaacc      840

ttcgaagaaa tccagaacca tccatggatg caagatgttc tcctgcccca ggaaactgct      900

gagatccacc tccacagcct gtcgccgggg cccagcaaat ag                         942


<210>  12
<211>  942
<212>  DNA
<213>  Mus musculus

<400>  12
atgctcctgt ccaagatcaa ctccctggcc cacctgcgcg ccgcgccctg caacgacctg       60

cacgccacca agctggcgcc gggcaaagag aaggagcccc tggagtcgca gtaccaggtg      120

ggcccgctgt tgggcagcgg tggcttcggc tcggtctact ctggcatccg cgtcgccgac      180

aacttgccgg tggccattaa gcacgtggag aaggaccgga tttccgattg gggagaactg      240

cccaatggca cccgagtgcc catggaagtg gtcctgttga agaaggtgag ctcggacttc      300

tcgggcgtca ttagacttct ggactggttc gagaggcccg atagtttcgt gctgatcctg      360

gagaggcccg aaccggtgca agacctcttc gactttatca ccgaacgagg agccctacag      420

gaggacctgg cccgaggatt cttctggcag gtgctggagg ccgtgcggca ttgccacaac      480

tgcggggttc tccaccgcga catcaaggac gagaacatct taatcgacct gagccgcggc      540

gaaatcaaac tcatcgactt cgggtcgggg gcgctgctca aggacacagt ctacacggac      600

tttgatggga cccgagtgta cagtcctcca gagtggattc gctaccatcg ctaccacggc      660

aggtcggcag ctgtctggtc ccttgggatc ctgctctatg acatggtctg cggagatatt      720

ccgtttgagc acgatgaaga gatcatcaag ggccaagtgt tcttcaggca aactgtctct      780

tcagagtgtc agcaccttat taaatggtgc ctgtccctga gaccatcaga tcggccctcc      840

tttgaagaaa tccggaacca tccatggatg cagggtgacc tcctgcccca ggcagcttct      900

gagatccatc tgcacagtct gtcaccgggg tccagcaagt ag                         942


<210>  13
<211>  10570
<212>  DNA
<213>  artificial sequence

<220>
<223>  lentiviral construct

<400>  13
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagcgcgtt ttgcctgtac tgggtctctc      840

tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc actgcttaag      900

cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct      960

ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag cagtggcgcc     1020

cgaacaggga cctgaaagcg aaagggaaac cagaggagct ctctcgacgc aggactcggc     1080

ttgctgaagc gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccaaaaattt     1140

tgactagcgg aggctagaag gagagagatg ggtgcgagag cgtcagtatt aagcggggga     1200

gaattagatc gcgatgggaa aaaattcggt taaggccagg gggaaagaaa aaatataaat     1260

taaaacatat agtatgggca agcagggagc tagaacgatt cgcagttaat cctggcctgt     1320

tagaaacatc agaaggctgt agacaaatac tgggacagct acaaccatcc cttcagacag     1380

gatcagaaga acttagatca ttatataata cagtagcaac cctctattgt gtgcatcaaa     1440

ggatagagat aaaagacacc aaggaagctt tagacaagat agaggaagag caaaacaaaa     1500

gtaagaccac cgcacagcaa gcggccgctg atcttcagac ctggaggagg agatatgagg     1560

gacaattgga gaagtgaatt atataaatat aaagtagtaa aaattgaacc attaggagta     1620

gcacccacca aggcaaagag aagagtggtg cagagagaaa aaagagcagt gggaatagga     1680

gctttgttcc ttgggttctt gggagcagca ggaagcacta tgggcgcagc gtcaatgacg     1740

ctgacggtac aggccagaca attattgtct ggtatagtgc agcagcagaa caatttgctg     1800

agggctattg aggcgcaaca gcatctgttg caactcacag tctggggcat caagcagctc     1860

caggcaagaa tcctggctgt ggaaagatac ctaaaggatc aacagctcct ggggatttgg     1920

ggttgctctg gaaaactcat ttgcaccact gctgtgcctt ggaatgctag ttggagtaat     1980

aaatctctgg aacagatttg gaatcacacg acctggatgg agtgggacag agaaattaac     2040

aattacacaa gcttaataca ctccttaatt gaagaatcgc aaaaccagca agaaaagaat     2100

gaacaagaat tattggaatt agataaatgg gcaagtttgt ggaattggtt taacataaca     2160

aattggctgt ggtatataaa attattcata atgatagtag gaggcttggt aggtttaaga     2220

atagtttttg ctgtactttc tatagtgaat agagttaggc agggatattc accattatcg     2280

tttcagaccc acctcccaac cccgagggga cccgacaggc ccgaaggaat agaagaagaa     2340

ggtggagaga gagacagaga cagatccatt cgattagtga acggatccga tccacaaatg     2400

gcagtattca tccacaattt taaaagaaaa ggggggattg gggggtacag tgcaggggaa     2460

agaatagtag acataatagc aacagacata caaactaaag aattacaaaa acaaattaca     2520

aaaattcaaa attttcgggt ttattacagg gacagcagag atccagtttg gcctgcagag     2580

atccagagtt aggcagggac attcaccatt atcgtttcag acccacctcc caaccccggt     2640

catatgggaa tgaaagaccc cacctgtagg tttggcaagc taggatcaag gttaggaaca     2700

gagagacagc agaatatggg ccaaacagga tatctgtggt aagcagttcc tgccccggct     2760

cagggccaag aacagttgga acaggagaat atgggccaaa caggatatct gtggtaagca     2820

gttcctgccc cggctcaggg ccaagaacag atggtcccca gatgcggtcc cgccctcagc     2880

agtttctaga gaaccatcag atgtttccag ggtgccccaa ggacctgaaa tgaccctgtg     2940

ccttatttga actaaccaat cagttcgctt ctcgcttctg ttcgcgcgct tctgctcccc     3000

gagctctata taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca     3060

cgctgttttg acctccatag aagatcagtt aattaagaat tcgcccctct ccctcccccc     3120

cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt     3180

tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct     3240

tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga     3300

atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga     3360

ccctttgcag gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac     3420

gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag     3480

ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc     3540

agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg     3600

tttagtcgag gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt     3660

gaaaaacacg atgataatat ggccacaacc atggtgagca agggcgagga gctgttcacc     3720

ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg     3780

tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc     3840

accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag     3900

tgcttcagcc gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc     3960

gaaggctacg tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc     4020

gccgaggtga agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac     4080

ttcaaggagg acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac     4140

gtctatatca tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac     4200

aacatcgagg acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc     4260

gacggccccg tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa     4320

gaccccaacg agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc     4380

actctcggca tggacgagct gtacaagtaa agcggccgca ctgttctcat cacatcatat     4440

caaggttata taccatcaat attgccacag atgttactta gccttttaat atttctctaa     4500

tttagtgtat atgcaatgat agttctctga tttctgagat tgagtttctc atgtgtaatg     4560

attatttaga gtttctcttt catctgttca aatttttgtc tagttttatt ttttactgat     4620

ttgtaagact tctttttata atctgcatat tacaattctc tttactgggg tgttgcaaat     4680

attttctgtc attctatggc ctgacttttc ttaatggttt tttaatttta aaaataagtc     4740

ttaatattca tgcaatctaa ttaacaatct tttctttgtg gttaggactt tgagtcataa     4800

gaaatttttc tctacactga agtcatgatg gcatgcttct atattatttt ctaaaagatt     4860

taaagttttg ccttctccat ttagacttat aattcactgg aatttttttg tgtgtatggt     4920

atgacatatg ggttcccttt tattttttac atataaatat atttccctgt ttttctaaaa     4980

aagaaaaaga tcatcatttt cccattgtaa aatgccatat ttttttcata ggtcacttac     5040

atatatcaat gggtctgttt ctgagctcta ctctatttta tcagcctcac tgtctatccc     5100

cacacatctc atgctttgct ctaaatcttg atatttagtg gaacattctt tcccattttg     5160

ttctacaaga atatttttgt tattgtcttt gggctttcta tatacatttt gaaatgaggt     5220

tgacaagttt ctagagttaa ctcgagggat caagcttatc gataatcaac ctctggatta     5280

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     5340

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     5400

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     5460

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     5520

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     5580

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     5640

cgtggtgttg tcggggaagc tgacgtcctt tccatggctg ctcgcctgtg ttgccacctg     5700

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     5760

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     5820

gagtcggatc tccctttggg ccgcctcccc gcatcgatac cgtcgagacc tagaaaaaca     5880

tggagcaatc acaagtagca acacagcagc taccaatgct gattgtgcct ggctagaagc     5940

acaagaggag gaggaggtgg gttttccagt cacacctcag gtacctttaa gaccaatgac     6000

ttacaaggca gctgtagatc ttagccactt tttaaaagaa aaggggggac tggaagggct     6060

aattcactcc caacgaagac aagatatcct tgatctgtgg atctaccaca cacaaggcta     6120

cttccctgat tggcagaact acacaccagg gccagggatc agatatccac tgacctttgg     6180

atggtgctac aagctagtac cagttgagca agagaaggta gaagaagcca atgaaggaga     6240

gaacacccgc ttgttacacc ctgtgagcct gcatgggatg gatgacccgg agagagaagt     6300

attagagtgg aggtttgaca gccgcctagc atttcatcac atggcccgag agctgcatcc     6360

ggactgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact     6420

agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc     6480

ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa     6540

aatctctagc agggcccgtt taaacccgct gatcagcctc gactgtgcct tctagttgcc     6600

agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca     6660

ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta     6720

ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc     6780

atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcta     6840

gggggtatcc ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc     6900

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt     6960

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggc atccctttag     7020

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt     7080

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt     7140

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt     7200

cttttgattt ataagggatt ttggggattt cggcctattg gttaaaaaat gagctgattt     7260

aacaaaaatt taacgcgaat taattctgtg gaatgtgtgt cagttagggt gtggaaagtc     7320

cccaggctcc ccaggcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca     7380

ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt     7440

agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact ccgcccagtt     7500

ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag gccgaggccg     7560

cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc ctaggctttt     7620

gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcagcac gtgttgacaa     7680

ttaatcatcg gcatagtata tcggcatagt ataatacgac aaggtgagga actaaaccat     7740

ggccaagttg accagtgccg ttccggtgct caccgcgcgc gacgtcgccg gagcggtcga     7800

gttctggacc gaccggctcg ggttctcccg ggacttcgtg gaggacgact tcgccggtgt     7860

ggtccgggac gacgtgaccc tgttcatcag cgcggtccag gaccaggtgg tgccggacaa     7920

caccctggcc tgggtgtggg tgcgcggcct ggacgagctg tacgccgagt ggtcggaggt     7980

cgtgtccacg aacttccggg acgcctccgg gccggccatg accgagatcg gcgagcagcc     8040

gtgggggcgg gagttcgccc tgcgcgaccc ggccggcaac tgcgtgcact tcgtggccga     8100

ggagcaggac tgacacgtgc tacgagattt cgattccacc gccgccttct atgaaaggtt     8160

gggcttcgga atcgttttcc gggacgccgg ctggatgatc ctccagcgcg gggatctcat     8220

gctggagttc ttcgcccacc ccaacttgtt tattgcagct tataatggtt acaaataaag     8280

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt     8340

gtccaaactc atcaatgtat cttatcatgt ctgtataccg tcgacctcta gctagagctt     8400

ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca     8460

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact     8520

cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct     8580

gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc     8640

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca     8700

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg     8760

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca     8820

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa     8880

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc     8940

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc     9000

gctttctcaa tgctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct     9060

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg     9120

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag     9180

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta     9240

cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg     9300

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt     9360

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     9420

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag     9480

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat     9540

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc     9600

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat     9660

aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc     9720

acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag     9780

aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag     9840

agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt     9900

ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg     9960

agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt    10020

tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc    10080

tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc    10140

attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa    10200

taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg    10260

aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc    10320

caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag    10380

gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt    10440

cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt    10500

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc    10560

acctgacgtc                                                           10570


