                         SEQUENCE LISTING

<110>  Schering Corporation
       Banerjee, Antara
       Heyworth, Paul G.
 
<120>  Modulation of PILR Receptors to Treat Sepsis

<130>  BP2009.6976WO

<150>  61/179,981
<151>  2009-05-20

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1323
<212>  DNA
<213>  Homo sapiens


<220>
<221>  sig_peptide
<222>  (213)..(269)

<400>  1
aataggggaa aataagccag atggataaag gaagtgctgg tcaccctgga ggtgcactgg       60

tttggggaag gctcctggcc cccacagccc tcttcggagc ctgagcccgg ctctcctcac      120

tcacctcaac ccccaggcgg cccctccaca gggcccctct cctgcctgga cggctctgct      180

ggtctccccg tcccctggag aagaacaagg ccatgggtcg gcccctgctg ctgcccctac      240

tgcccttgct gctgccgcca gcatttctgc agcctagtgg ctccacagga tctggtccaa      300

gctaccttta tggggtcact caaccaaaac acctctcagc ctccatgggt ggctctgtgg      360

aaatcccctt ctccttctat tacccctggg agttagccac agctcccgac gtgagaatat      420

cctggagacg gggccacttc cacaggcagt ccttctacag cacaaggccg ccttccattc      480

acaaggatta tgtgaaccgg ctctttctga actggacaga gggtcagaag agcggcttcc      540

tcaggatctc caacctgcag aagcaggacc agtctgtgta tttctgccga gttgagctgg      600

acacacggag ctcagggagg cagcagtggc agtccatcga ggggaccaaa ctctccatca      660

cccaggctgt cacgaccacc acccagaggc ccagcagcat gactaccacc tggaggctca      720

gtagcacaac caccacaacc ggcctcaggg tcacacaggg caaacgacgc tcagactctt      780

ggcacataag tctggagact gctgtggggg tggcagtggc tgtcactgtg ctcggaatca      840

tgattttggg actgatctgc ctcctcaggt ggaggagaag gaaaggtcag cagcggacta      900

aagccacaac cccagccagg gaacccttcc aaaacacaga ggagccatat gagaatatca      960

ggaatgaagg acaaaataca gatcccaagc taaatcccaa ggatgacggc atcgtctatg     1020

cttcccttgc cctctccagc tccacctcac ccagagcacc tcccagccac cgtcccctca     1080

agagccccca gaacgagacc ctgtactctg tcttaaaggc ctaaccaatg gacagccctc     1140

tcaagactga atggtgaggc caggtacagt ggcgcacacc tgtaatccca gctactctga     1200

agcctgaggc agaatcaagt gagcccagga gttcagggcc agctttgata atggagcgag     1260

atgccatctc tagttaaaaa tatatattaa caataaagta acaaatttaa aaagataaaa     1320

aaa                                                                   1323


<210>  2
<211>  303
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  mat_peptide
<222>  (20)..(303)

<400>  2

Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
                -15                 -10                 -5      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
        -1  1               5                   10              


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
    15                  20                  25                  


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
30                  35                  40                  45  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Arg Gln Ser 
                50                  55                  60      


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
            65                  70                  75          


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
        80                  85                  90              


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
    95                  100                 105                 


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
110                 115                 120                 125 


Thr Lys Leu Ser Ile Thr Gln Ala Val Thr Thr Thr Thr Gln Arg Pro 
                130                 135                 140     


Ser Ser Met Thr Thr Thr Trp Arg Leu Ser Ser Thr Thr Thr Thr Thr 
            145                 150                 155         


Gly Leu Arg Val Thr Gln Gly Lys Arg Arg Ser Asp Ser Trp His Ile 
        160                 165                 170             


Ser Leu Glu Thr Ala Val Gly Val Ala Val Ala Val Thr Val Leu Gly 
    175                 180                 185                 


Ile Met Ile Leu Gly Leu Ile Cys Leu Leu Arg Trp Arg Arg Arg Lys 
190                 195                 200                 205 


Gly Gln Gln Arg Thr Lys Ala Thr Thr Pro Ala Arg Glu Pro Phe Gln 
                210                 215                 220     


Asn Thr Glu Glu Pro Tyr Glu Asn Ile Arg Asn Glu Gly Gln Asn Thr 
            225                 230                 235         


Asp Pro Lys Leu Asn Pro Lys Asp Asp Gly Ile Val Tyr Ala Ser Leu 
        240                 245                 250             


Ala Leu Ser Ser Ser Thr Ser Pro Arg Ala Pro Pro Ser His Arg Pro 
    255                 260                 265                 


Leu Lys Ser Pro Gln Asn Glu Thr Leu Tyr Ser Val Leu Lys Ala 
270                 275                 280                 


<210>  3
<211>  3632
<212>  DNA
<213>  Homo sapiens


<220>
<221>  sig_peptide
<222>  (2497)..(2553)

<400>  3
agaagggagg tagtcgccct ccgtcgtggc ctggcgtgga ttccgagcgt tggtgtctgg       60

cggtttccga ccgttggtgt ctggcacgcg ccaccccgat gtaccaggta aagccctatc      120

acggggtcgg cgcccctctc cgtgtggagc ccacctgcat gtactggctc cccaacatgc      180

acggcaggag cggcggccca gcactcggca ctggccactt gcagacaaga agacaagaaa      240

atgatttgag gacagcttca atcgcggtgt gaagaagaaa gcaacaaaac gaccactgaa      300

aacaatgccg gtggcaaaac atccaaagaa agggtcccaa gtggtacatc gtcatagctg      360

gaaacagtca gagccaccag ccaatgatct tttcaatgct gcgaaagctg ccaaaagtga      420

catgcagtgt ggccatgagg tctgccggaa gtgacttgtt ggtgttatct cctgagttaa      480

aatgtgaagg gatttttttt tttcagatta ctgagagtct tcagttacta gaggcggatt      540

tccctgactg aagaccatgt tgcaggccca cagctgccta cagaaccgtc ccaaaatatg      600

gcaaagaaac ctattctgag cgatagggtc tcaccatgtt gcccaggctg gtcttgaact      660

cctggactca tcctaaagtg ctggcctctc attccctgtc tgtgcacacc tcacggcaag      720

ggccagcctg tttcctcccg gtcacctcca aatcttgctg cttttaattc aactcagagg      780

cctagccagg gttgagttct cacccacctg tgccgccctg ccttgttacc tggaagcaca      840

gccttgggga ctgagcaggc cctcactgtc actttaagaa gggaatcagc cactttgtgc      900

tcaccacctc tggggaaggt gtgagaggag agaaggaagt ggctgtttgg ctgctgacaa      960

catgaagact tcctgcgatg agaacagagg cacaggtgcc ggccctgcag cccccagaac     1020

ccggactgga gggggccatg gggcgccgga ccctggccct gccctgggtg ctgctgaccc     1080

tgcgtgtcac tgcagggacc ccggaggtgt gagtacaagt tcggatggag gccaccgagc     1140

tctcgtcctt caccatccgt tgtgggttcc tggagtctgg ctccatctcc ctggtgactg     1200

cccgctggga aacccagagc agcatctctc tcatcctgga aggctctggg gccagcagcc     1260

cctgcgccaa caccaccttc tgctgcaagt ttgcgtcctt ccctgagggc tcctgggagg     1320

cctgtgggag cctcccgccc agctcagacc cagggctctc tgtcccgccg actcctgccc     1380

ccattctgcg ggcagacctg gccgggatct tgggggtctc aggagtcctt ctctttgact     1440

gtggctacct ccttcatctg ctgtgccgac agaagcaccg ccctgcccct aggctccagc     1500

catcccacac cagctcctag gcactgagag cacgagcatg ggcacccagc caggcctccc     1560

aggctgctct ccacgtccct tatgccacta tcaacaccag ctgctgccca gctactttgg     1620

acacagctca cccccgacag ggggccgtcc tggtgggcat cactccccac ccacaccgca     1680

cactggcccc agggccctgc tgcctgggcc tccacatcca tccctgcaca tggcagcttt     1740

gtctctgttg agaatggact ctacgcttag gctgggcaga ggcctccctg cactggtcct     1800

ggcctcactc ttttccctga cccttggggc ccagggccat ggagggaccc ttaggagttc     1860

aatgagagag accatgaggc cactgggctt tccccttccc aggcctcctg ggtgccaccc     1920

ccttacgtta ttcttgggcc tctaataagt gtcccacagg tgcctggcca ggcccacctg     1980

ctgcagatgt ggtctgtgtg tgtgcatgtg tgggtgtgtg tgggcacagg tgtgagtgtg     2040

tgagcaacag taccccattc cagtcgtttc ctgctgtgac taagtcagca acacagttcc     2100

tctgacatgg gccttggctg tgcttctttg ggggtgaaga gattggggag gaagtctcca     2160

cccctgggag gcagaagcca ggcatagcgc gctggctagg actccagtac cgtgaaggga     2220

ggcagtgaga gcagacatct gtgcctcatt cctgatctca aggggaaagc aagaacaagg     2280

gaggcttcct caggatctcg aacctgcgga aggaggacca gtctgtgtac ttctgccaag     2340

tccagctgga catacagatc agggaggctg tcgtggcagt ccatcaaggg gacccacctc     2400

accatcaccc aggccctcag gcagcccctc cacagggccc ctctcctgcc tggacagctc     2460

tgctggtctc cccgtcccct ggagaagaac aaggccatgg gtcggcccct gctgctgccc     2520

ctgctgctcc tgctgcagcc gccagcattt ctgcagcctg gtggctccac aggatctggt     2580

ccaagctacc tttatggggt cactcaacca aaacacctct cagcctccat gggtggctct     2640

gtggaaatcc ccttctcctt ctattacccc tgggagttag ccatagttcc caacgtgaga     2700

atatcctgga gacggggcca cttccacggg cagtccttct acagcacaag gccgccttcc     2760

attcacaagg attatgtgaa ccggctcttt ctgaactgga cagagggtca ggagagcggc     2820

ttcctcagga tctcaaacct gcggaaggag gaccagtctg tgtatttctg ccgagtcgag     2880

ctggacaccc ggagatcagg gaggcagcag ttgcagtcca tcaaggggac caaactcacc     2940

atcacccagg ctgtcacaac caccaccacc tggaggccca gcagcacaac caccatagcc     3000

ggcctcaggg tcacagaaag caaagggcac tcagaatcat ggcacctaag tctggacact     3060

gccatcaggg ttgcattggc tgtcgctgtg ctcaaaactg tcattttggg actgctgtgc     3120

ctcctcctcc tgtggtggag gagaaggaaa ggtagcaggg cgccaagcag tgacttctga     3180

ccaacagagt gtggggagaa gggatgtgta ttagccccgg aggacgtgat gtgagacccg     3240

cttgtgagtc ctccacactc gttccccatt ggcaagatac atggagagca ccctgaggac     3300

ctttaaaagg caaagccgca aggcagaagg aggctgggtc cctgaatcac cgactggagg     3360

agagttacct acaagagcct tcatccagga gcatccacac tgcaatgata taggaatgag     3420

gtctgaactc cactgaatta aaccactggc atttgggggc tgtttattat agcagtgcaa     3480

agagttcctt tatcctcccc aaggatggaa aaatacaatt tattttgctt accatacacc     3540

ccttttctcc tcgtccacat tttccaatct gtatggtggc tgtcttctat ggcagaaggt     3600

tttggggaat aaatagcgtg aaatgctgct ga                                   3632


<210>  4
<211>  227
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  mat_peptide
<222>  (20)..(227)

<400>  4

Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Gln Pro Pro 
                -15                 -10                 -5      


Ala Phe Leu Gln Pro Gly Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
        -1  1               5                   10              


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
    15                  20                  25                  


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Ile Val 
30                  35                  40                  45  


Pro Asn Val Arg Ile Ser Trp Arg Arg Gly His Phe His Gly Gln Ser 
                50                  55                  60      


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
            65                  70                  75          


Leu Phe Leu Asn Trp Thr Glu Gly Gln Glu Ser Gly Phe Leu Arg Ile 
        80                  85                  90              


Ser Asn Leu Arg Lys Glu Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
    95                  100                 105                 


Leu Asp Thr Arg Arg Ser Gly Arg Gln Gln Leu Gln Ser Ile Lys Gly 
110                 115                 120                 125 


Thr Lys Leu Thr Ile Thr Gln Ala Val Thr Thr Thr Thr Thr Trp Arg 
                130                 135                 140     


Pro Ser Ser Thr Thr Thr Ile Ala Gly Leu Arg Val Thr Glu Ser Lys 
            145                 150                 155         


Gly His Ser Glu Ser Trp His Leu Ser Leu Asp Thr Ala Ile Arg Val 
        160                 165                 170             


Ala Leu Ala Val Ala Val Leu Lys Thr Val Ile Leu Gly Leu Leu Cys 
    175                 180                 185                 


Leu Leu Leu Leu Trp Trp Arg Arg Arg Lys Gly Ser Arg Ala Pro Ser 
190                 195                 200                 205 


Ser Asp Phe 
            


<210>  5
<211>  1255
<212>  DNA
<213>  Homo sapiens


<220>
<221>  sig_peptide
<222>  (175)..(240)

<400>  5
ggaggccggg gcggggcggg cgcagccggc gctgagcttg cagggccgct cccctcaccc       60

gcccccttcg agtccccggg cttcgcccca cccggcccgt gggggagtat ctgtcctgcc      120

gccttcgccc acgccctgca ctccgggacc gtccctgcgc gctctgggcg caccatggcc      180

cgcggggctg cgctggcgct gctgctcttc ggcctgctgg gtgttctggt cgccgccccg      240

gatggtggtt tcgatttatc cgatgccctt cctgacaatg aaaacaagaa acccactgca      300

atccccaaga aacccagtgc tggggatgac tttgacttag gagatgctgt tgttgatgga      360

gaaaatgacg acccacgacc accgaaccca cccaaaccga tgccaaatcc aaaccccaac      420

caccctagtt cctccggtag cttttcagat gctgaccttg cggatggcgt ttcaggtgga      480

gaaggaaaag gaggcagtga tggtggaggc agccacagga aagaagggga agaggccgac      540

gccccaggcg tgatccccgg gattgtgggg gctgtcgtgg tcgccgtggc tggagccatc      600

tctagcttca ttgcttacca gaaaaagaag ctatgcttca aagaaaatgc agaacaaggg      660

gaggtggaca tggagagcca ccggaatgcc aacgcagagc cagctgttca gcgtactctt      720

ttagagaaat agaagattgt cggcagaaac agcccaggcg ttggcagcag ggttagaaca      780

gctgcctgag gctcctccct gaaggacacc tgcctgagag cagagatgga ggccttctgt      840

tcacggcgga ttctttgttt taatcttgcg atgtgctttg cttgttgctg ggcggatgat      900

gtttactaac gatgaatttt acatccaaag ggggataggc acttggaccc ccattctcca      960

aggcccgggg gggcggtttc ccatgggatg tgaaaggctg gccattatta agtccctgta     1020

actcaaatgt caaccccacc gaggcacccc cccgtccccc agaatcttgg ctgtttacaa     1080

atcacgtgtc catcgagcac gtctgaaacc cctggtagcc ccgacttctt tttaattaaa     1140

ataaggtaag cccttcaatt tgtttcttca atatttcttt catttgtagg gatatttgtt     1200

tttcatatca gactaataaa aagaaattag aaaccaaaaa aaaaaaaaaa aaaaa          1255


<210>  6
<211>  185
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(22)

<220>
<221>  mat_peptide
<222>  (23)..(185)

<400>  6

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
        -20                 -15                 -10             


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
    -5              -1  1               5                   10  


Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 
                15                  20                  25      


Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
            30                  35                  40          


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
        45                  50                  55              


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
    60                  65                  70                  


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
75                  80                  85                  90  


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
                95                  100                 105     


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
            110                 115                 120         


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 
        125                 130                 135             


Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 
    140                 145                 150                 


Ala Val Gln Arg Thr Leu Leu Glu Lys 
155                 160             


<210>  7
<211>  1207
<212>  DNA
<213>  Homo sapiens


<220>
<221>  sig_peptide
<222>  (175)..(240)

<400>  7
ggaggccggg gcggggcggg cgcagccggc gctgagcttg cagggccgct cccctcaccc       60

gcccccttcg agtccccggg cttcgcccca cccggcccgt gggggagtat ctgtcctgcc      120

gccttcgccc acgccctgca ctccgggacc gtccctgcgc gctctgggcg caccatggcc      180

cgcggggctg cgctggcgct gctgctcttc ggcctgctgg gtgttctggt cgccgccccg      240

gatggtggtt tcgatttatc cgatgccctt cctggggatg actttgactt aggagatgct      300

gttgttgatg gagaaaatga cgacccacga ccaccgaacc cacccaaacc gatgccaaat      360

ccaaacccca accaccctag ttcctccggt agcttttcag atgctgacct tgcggatggc      420

gtttcaggtg gagaaggaaa aggaggcagt gatggtggag gcagccacag gaaagaaggg      480

gaagaggccg acgccccagg cgtgatcccc gggattgtgg gggctgtcgt ggtcgccgtg      540

gctggagcca tctctagctt cattgcttac cagaaaaaga agctatgctt caaagaaaat      600

gcagaacaag gggaggtgga catggagagc caccggaatg ccaacgcaga gccagctgtt      660

cagcgtactc ttttagagaa atagaagatt gtcggcagaa acagcccagg cgttggcagc      720

agggttagaa cagctgcctg aggctcctcc ctgaaggaca cctgcctgag agcagagatg      780

gaggccttct gttcacggcg gattctttgt tttaatcttg cgatgtgctt tgcttgttgc      840

tgggcggatg atgtttacta acgatgaatt ttacatccaa agggggatag gcacttggac      900

ccccattctc caaggcccgg gggggcggtt tcccatggga tgtgaaaggc tggccattat      960

taagtccctg taactcaaat gtcaacccca ccgaggcacc cccccgtccc ccagaatctt     1020

ggctgtttac aaatcacgtg tccatcgagc acgtctgaaa cccctggtag ccccgacttc     1080

tttttaatta aaataaggta agcccttcaa tttgtttctt caatatttct ttcatttgta     1140

gggatatttg tttttcatat cagactaata aaaagaaatt agaaaccaaa aaaaaaaaaa     1200

aaaaaaa                                                               1207


<210>  8
<211>  169
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(22)

<220>
<221>  mat_peptide
<222>  (23)..(169)

<400>  8

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
        -20                 -15                 -10             


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
    -5              -1  1               5                   10  


Pro Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
                15                  20                  25      


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
            30                  35                  40          


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
        45                  50                  55              


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
    60                  65                  70                  


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
75                  80                  85                  90  


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
                95                  100                 105     


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 
            110                 115                 120         


Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 
        125                 130                 135             


Ala Val Gln Arg Thr Leu Leu Glu Lys 
    140                 145         


