SEQUENCE LISTING

<110>  Borca, Manuel
       Zhu, James
 
<120>  Mutations in a Toll-Like Receptor Motif in the NS4B of Classical

<130>  D.N. 0096.08

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  12285
<212>  DNA
<213>  Classical swine fever virus

<400>  1
agttcattct cgtgtacatg attggacaaa tcaaaatctc aatttggttc agggcctccc       60

tccagcgacg gccgagctgg gctagccatg cccacagtag gactagcaaa cggagggact      120

agccgtagtg gcgagctccc tgggtggtct aagtcctgag tacaggacag tcgtcagtag      180

ttcgacgtga gcagaagccc acctcgagat gctatgtgga cgagggcatg cccaagacac      240

accttaaccc tagcgggggt cgttagggtg aaatcacacc atgtgatggg agtacgacct      300

gatagggtgc tgcagaggcc cactattagg ctagtataaa aatctctgct gtacatggca      360

catggagttg aatcattttg aacttttata caaaacaaac aaacaaaaac caatgggagt      420

ggaggaaccg gtatacgatg taacggggag accattgttt ggagacccaa gtgaggtaca      480

cccacaatca acattgaagc taccacatga tagggggaga ggcaacatca aaacaacact      540

gaagaaccta cctaggagag gtgactgcag gagtggcaac cacctaggcc cggttagtgg      600

gatatatgta aagcccggcc ctgtctttta tcaggactac atgggcccag tctatcatag      660

agcccctcta gagttttttg acgaagcaca gttttgtgag gtgaccaaaa ggataggtag      720

ggtgacaggt agtgacggaa agctttacca tatatacgtg tgcatcgatg gttgcatcct      780

gctgaagcta gccaagaggg gcgagccaag aaccctgaag tggattagaa atctcaccga      840

ctgtccattg tgggttacca gttgttctga tgatggtgca agtgcaagta aagagaagaa      900

accagatagg atcaacaagg gtaaattaaa gatagcccca aaagagcatg agaaggacag      960

caggactaag ccacctgatg ctacgattgt agtggaagga gtaaaatacc aggtcaaaaa     1020

gaaaggtaaa gttaagggaa agaataccca agacggcctg taccacaaca agaataaacc     1080

accagaatct aggaagaaat tagaaaaagc cctattggca tgggcagtga tagcaattat     1140

gttataccaa cctgttgcag ccgaaaatat aactcaatgg aacctgagtg acaacggtac     1200

caatggtatc cagcacgcta tgtaccttag aggagtcagc agaagcttgc atgggatctg     1260

gccagaaaaa atatgcaaag gagtccccac ctacctggcc acagacacgg aactgagaga     1320

aatacaggga atgatggatg ccagcgaggg gacaaactat acgtgctgta agttacagag     1380

acatgaatgg aacaaacatg gatggtgtaa ctggtataac atagacccct ggatacagtt     1440

gatgaataga acccaagcaa acttggcaga aggccctccg agcaaggagt gcgccgtgac     1500

ttgcaggtac gataaaaatg ctgacattaa cgtggtcacc caggccagaa acaggccaac     1560

caccctaact ggctgcaaga aagggaaaaa tttttctttt gcgggtacag ttatagaggg     1620

cccatgtaat ttcaacgttt ctgttgagga tatcttatat ggggatcatg agtgtggcag     1680

tctactccag gatacggctc tatacctagt agatggaatg accaacacta tagagagagc     1740

caggcaggga gccgcgaggg tgacatcttg gctagggagg caactcagaa ctgccgggaa     1800

gaggttggag ggcagaagca aaacctggtt tggtgcctat gccctatcac cttattgtaa     1860

tgtgacaagc aaaatagggt acatatggta cactaacaac tgtaccccgg cttgcctccc     1920

caaaaataca aagataatag gccccggtaa atttgacact aacgcggaag acggaaagat     1980

tctccatgag atggggggcc acctatcaga atttctgctg ctctctctgg tcgttctgtc     2040

tgacttcgcc cctgaaacag ccagcgcgtt atacctcatt ttgcactacg tgatccctca     2100

atcccatgaa gaacctgaag gctgtgacac aaaccagctg aatttaacag tggaactcag     2160

gactgaagac gtgataccat catcagtctg gaatgttggc aaatatgtgt gtgttagacc     2220

agactggtgg ccatatgaaa ccaaggtggc tttgttattt gaagaggcag gacaggtcgt     2280

aaagttagcc ttgcgggcac tgagggattt aaccagggtc tggaatagcg catcaaccac     2340

ggcattcctc atctgcttga taaaagtatt aagaggacag gtcgtgcaag gtgtgatatg     2400

gctgttactg gtaactgggg cacaaggccg gctagcctgc aaggaagatc acaggtacgc     2460

tatatcaaca accaatgaga tagggctact tggggccgaa ggtctcacta ccacctggaa     2520

agaatacaac cacaatttgc aactggatga tgggaccgtc aaggccatct gcatggcagg     2580

ttcctttaaa gtcacagcac ttaatgtggt tagtaggagg tatctggcat cattacataa     2640

ggacgcttta cccacttccg tgacattcga gctcctgttc gacgggacca gcccattgac     2700

cgaggaaatg ggagatgact tcgggttcgg actgtgtccg tatgatacga gccctgtagt     2760

caagggaaag tacaacacaa ccttgttgaa tggtagtgca ttctacctag tttgcccaat     2820

agggtggacg ggtgttatag agtgcacggc agtgagcccg acaactctga gaacagaagt     2880

ggtaaagacc ttcagaagag agaaaccctt tccgtacaga agggattgtg tgaccactac     2940

agtggaaaat gaagatctat tctactgtaa atgggggggc aattggacat gtgtgaaagg     3000

tgaaccagtg acctacacgg gggggccagt aaaacaatgc agatggtgtg gcttcgactt     3060

caatgagcct gacggactcc cacactaccc cataggtaag tgcattttgg caaatgagac     3120

aggttacaga atagtggatt caacggactg taacagagat ggcgttgtaa tcagcacaga     3180

ggggagtcat gagtgcttga ttggtaacac aactgtcaag gtgcatgcat tagatgaaag     3240

actaggccct atgccatgca ggcctaagga gatcgtctct agtgcgggac ctgtaaggaa     3300

aacttcctgt acattcaact acgcaaaaac tctgaggaac aggtattatg agcccaggga     3360

cagctatttc caacaatata tgctcaaggg cgagtatcag tactggtttg atctggatgt     3420

gaccgaccgc cactcagatt acttcgcaga attcattgtc ttggtggtgg tggcactgtt     3480

gggaggaaga tatgtcctgt ggctaatagt gacctacata gttctaacag aacaactcgc     3540

cgctggtcta cagttaggcc agggtgaggt agtgttaata gggaacttaa tcacccacac     3600

agatattgag gttgtagtat atttcttact gctctatttg gtcatgagag atgagcctat     3660

aaagaaatgg atactactgc tgttccatgc tatgaccaac aatccagtta agaccataac     3720

agtggcactg ctcatggtta gcggggttgc caagggtgga aagatagatg gtggttggca     3780

gcggctgccg gagaccaact ttgatatcca actcgcgctg acagttatag tagtcgctgt     3840

gatgttgctg gcaaagaaag atccgactac cgtccccttg gttataacgg tggcaaccct     3900

gagaacggct aagataacta atggacttag tacagatcta gccatagcta cagtgtcaac     3960

agctttgcta acctggacct acattagtga ctattataaa tacaagacct tgctacagta     4020

ccttattagc acagtgacag gtatcttctt gataagggta ctgaaggggg taggtgagtt     4080

agatttacac accccaacct taccatctta cagacccctc ttcttcatcc tcgtgtacct     4140

catttccact gcagtggtaa caagatggaa tctggacata gccggattgc tgctgcagtg     4200

tgtcccaacc cttttaatgg ttttcacgat gtgggcagac atccttaccc tgatcctcat     4260

actgcctact tacgagttga caaaactata ttacctcaag gaagtgaaga ttggggcaga     4320

aaggggctgg ttgtggaaga ccaacttcaa gagggtaaat gacatatacg aagttgacca     4380

agctggtgag ggggtgtacc ttttcccatc aaaacaaaag acaggtacaa taacaggtac     4440

tatgttgcca ttgatcaaag ccatactcat aagttgcatc agcaataagt ggcaatttat     4500

atatctattg tacttgatat tcgaagtgtc ttactacctt cacaagaaga tcatagatga     4560

aatagcagga gggaccaact tcatctcgag acttgtagcc gctctgattg aagccaattg     4620

ggcctttgac aacgaagaag ttagaggttt aaagaagttc ttcctgctgt ctagtagggt     4680

taaagaactg atcatcaaac acaaagtgag gaatgaagtg atggtccact ggtttggcga     4740

cgaagaggtc tatgggatgc cgaagctggt tggcttagtc aaggcagcaa cactgagtaa     4800

aaataaacat tgtattttgt gcaccgtctg tgaaaacaga gagtggagag gagaaacctg     4860

cccaaaatgc ggccgttttg ggccaccagt gacctgtggc atgaccctag ccgactttga     4920

agaaaaacac tataagagga ttttctttag agaggatcaa tcagaagggc cggttaggga     4980

ggagtatgca gggtatctgc aatatagagc cagagggcaa ttattcctga ggaatctccc     5040

ggtgctagca acaaaagtca agatgctcct ggtcggaaat cttgggacgg aggtggggga     5100

tttggaacac cttggctggg tgctcagagg gcctgccgtt tgcaagaagg ttaccgaaca     5160

tgagaaatgc accacatcca taatggacaa attaactgct ttcttcggtg ttatgccaag     5220

gggcaccaca cctagagccc ctgtgagatt ccccacctct ctcttaaaga taagaagggg     5280

gctggaaact ggctgggcgt acacacacca aggtggcatc agttcagtgg accatgtcac     5340

ttgtgggaaa gacttactgg tatgtgacac tatgggccgg acaagggttg tttgccaatc     5400

aaataacaag atgacagacg agtccgagta tggagttaaa actgactccg gatgcccgga     5460

gggagctagg tgttacgtgt tcaacccaga ggcagttaac atatccggga ctaaaggagc     5520

catggtccac ttacaaaaaa ctggaggaga attcacctgt gtgacagcat cagggactcc     5580

ggccttcttt gatctcaaga acctcaaagg ctggtcaggg ctgccgatat ttgaggcatc     5640

aagtggaaga gtagtcggca gggttaaggt cgggaagaat gaggactcta aaccaaccaa     5700

gcttatgagt ggaatacaaa cagtctccaa aagtaccaca gacttgacag aaatggtaaa     5760

gaaaataaca accatgaaca ggggagaatt cagacaaata acccttgcca caggtgccgg     5820

aaaaaccacg gaactcccta gatcagtcat agaagagata ggaaggcata agagggtctt     5880

ggtcttgatc cctctgaggg cggcagcaga gtcagtatac caatatatga gacaaaaaca     5940

cccaagcata gcattcaact tgaggatagg ggagatgaag gaaggggaca tggccacagg     6000

gataacctat gcctcatatg gttacttctg tcagatgcca caacctaagc tgcgagccgc     6060

gatggttgag tactccttca tattccttga tgagtaccac tgtgccaccc ccgaacaatt     6120

ggctatcatg ggaaagatcc acagattttc agagaacctg cgggtagtag ccatgaccgc     6180

aacaccagca ggcacggtaa caactacagg gcaaaaacac cctatagaag aatacatagc     6240

cccagaagtg atgaaggggg aagacttagg ttcagagtac ttggacatag ctggactaaa     6300

gataccagta gaggagatga agagtaacat gctggtcttt gtgcccacaa ggaacatggc     6360

tgtagagacg gcaaagaaac tgaaagctaa gggttataac tcaggctact attatagtgg     6420

agaggatcca tctaacctga gggtggtaac atcacagtcc ccgtacgtgg tggtagcaac     6480

caacgcaata gaatcaggtg ttactctccc agacttggat gtggtcgtcg acacagggct     6540

taagtgtgaa aagaggatac ggctgtcacc taagatgccc ttcatagtga cgggcctgaa     6600

gagaatggct gtcacgattg gggaacaagc ccagagaagg gggagagttg ggagagtgaa     6660

gcctgggaga tactacagga gtcaagaaac ccccgttggt tccaaagatt accattacga     6720

cctactgcaa gcacagaggt acggtataga agatgggata aacatcacca aatcttttag     6780

agagatgaat tatgattgga gcctttatga ggaggatagt ctgatgatta cacaattgga     6840

aatcctcaac aatctgttga tatcagaaga gctaccaatg gcagtaaaaa atataatggc     6900

caggactgac cacccagaac caatccaact ggcgtacaac agctacgaaa cgcaggtgcc     6960

agtgctattc ccaaaaataa aaaatggaga ggtgactgac agttacgata actatacctt     7020

cctcaacgca agaaagctgg gggatgatgt acctccctac gtgtatgcca cagaggatga     7080

ggacttagcg gtagagctgc tgggcttaga ctggccggac cctgggaacc aaggaaccgt     7140

ggaggctggt agagcactaa aacaagtagt tggtctatca acagctgaga acgccctgtt     7200

agtagcttta ttcggctatg taggatatca ggcactctca aagaggcata taccagtagt     7260

cacagacata tattcaattg aagatcacag gttggaagac accacacacc tacagtatgc     7320

cccgaatgct atcaagacgg aggggaagga gacagaattg aaggagctag ctcaggggga     7380

tgtgcagaga tgtatggaag ctatgactaa ttatgcaaga gatggcatcc aattcatgaa     7440

gtctcaggca ctgaaagtga aagaaacccc cacttacaaa gagacaatgg acaccgtggc     7500

ggactatgta aagaagttca tggaggcact ggcggacagc aaagaagaca tcataaaata     7560

tgggttgtgg gggacgcaca caaccttata taagagcatc ggtgctaggc ttgggaacga     7620

gactgcgttc gctaccctgg tcgtgaaatg gctggcattt gggggagaat caatagcaga     7680

ccatgtcaaa caagcggcca cagacttggt cgtttactat atcatcaaca gacctcagtt     7740

cccaggagac acggagacac aacaggaagg aaggaaattt gtagccagcc tactggtctc     7800

agccctggct acttacactt acaaaagctg gaattacaat aatctgtcca agatagttga     7860

accggctttg gctactctgc cctatgccgc cacagctctc aagctattcg cccccactcg     7920

attggagagc gttgtcatac tgagtaccgc aatctacaaa acctacctat caatcaggcg     7980

cggaaaaagc gatggtttgc taggcacagg ggttagtgcg gctatggaaa tcatgtcaca     8040

aaacccagta tctgcggctg cagcggtcat gctaggggtg ggggccgtag cggcccacaa     8100

tgcaatcgaa gccagtgagc agaagagaac actactcatg aaagtttttg taaagaactt     8160

cttggatcag gcagccactg atgaattagt caaggagagc cctgagaaaa taataatggc     8220

tttgtttgaa gcagtgcaga cagtcggcaa ccctcttaga ctggtatacc acctttacgg     8280

agttttttac aaagggtggg aggcaaaaga gttggcccaa aggacagccg gtaggaatct     8340

tttcactttg ataatgtttg aggctgtgga actactggga gtagatagcg aaggaaagat     8400

ccgccagcta tcaagcaatt acatactaga gctcctgtat aagttccgtg acagtatcaa     8460

gtccagcgtg aggcagatgg caatcagctg ggcccctgcc ccttttagtt gtgattggac     8520

accgacggat gacagaatag ggcttcccca agataatttc ctccgagtgg agacaaaatg     8580

cccctgtggt tacaagatga aagcagttaa gaattgtgct ggggagttga gactcttaga     8640

agaggaaggc tcatttctct gcaggaataa attcgggaga ggttcacgga actacagggt     8700

gacaaaatac tatgatgaca atctatcaga aataaagcca gtgataagaa tggaaggaca     8760

tgtggaactc tactacaagg gagccactat taaactggat ttcaacaaca gtaaaacaat     8820

attggcaacc gataaatggg aggtcgatca ctccactctg gtcagggtgc tcaagaggca     8880

cacaggggct ggatatcgtg gggcatacct gggtgagaaa ccgaaccaca aacatctgat     8940

agagagggac tgcgcaacca tcaccaaaga taaggtttgt tttctcaaga tgaagagagg     9000

gtgtgcattt acttatgact tatcccttca caaccttacc cggctgatcg aattggtaca     9060

caagaataac ttggaagaca aagagattcc tgccgttacg gtcacaacct ggctggctta     9120

cacatttgta aatgaagata tagggaccat aaaaccagcc ttcggggaga aaataacacc     9180

agagatgcag gaggagataa ccttgcagcc tgctgtagtg gtggatgcaa ctgacgtgac     9240

cgtgaccgtg gtaggggaaa cccctactat gactacaggg gagaccccaa caacgttcac     9300

cagctcaggt ccagacccga aaggccaaca agttttaaaa ctgggagtag gtgaaggcca     9360

ataccccggg actaatccac agagagcaag cctgcacgaa gccatacaaa gcgcagatga     9420

aaggccctct gtgttgatat tggggtctga taaagccacc tctaatagag tgaaaactgt     9480

aaagaatgtg aaggtataca gaggcaggga cccactagaa gtgagagata tgatgaggag     9540

gggaaagatc ctagtcatag ccctgtctag ggttgataat gctctattga aatttgtaga     9600

ttacaaaggc acctttctaa ctagagagac cctggaggca ttaagtttgg gtaggccaaa     9660

aaagaaaaac ataaccaagg cagaagcaca gtggttgctg cgcctcgaag accaaatgga     9720

agagctaccc gattggttcg cagccgggga acccattttt ttagaggcca atattaaaca     9780

tgacaggtat catctggtag gggatatagc tactatcaaa gagaaagcca aacaattggg     9840

ggctacagac tctacaaaga tatccaagga ggttggtgca aaagtatatt ctatgaaatt     9900

gagtaattgg gtgatgcaag aagaaaacaa acagagcaac ttgaccccct tatttgaaga     9960

gctcctacag cagtgtccac ccggaggcca aaacaaaact gcacatatgg tctctgctta    10020

ccaactagct caagggaact ggatgccaac cagctgccat gtttttatgg ggaccatatc    10080

tgccagaagg actaagaccc atccatatga agcatatgtc aagttaaggg agttggtaga    10140

ggaacacaag atgaaaacat tgtgtcccgg atcaagtctg cgtaagcaca atgaatgggt    10200

aattggcaag atcaaatacc agggcaacct gaggaccaaa cacatgttga accccggcaa    10260

ggtggcagag caactgcaca gagaaggaca cagacacaat gtgtataaca agacaatagg    10320

ctcagtgatg acagctactg gcatcaggtt ggagaagttg cccgtggtta gggcccagac    10380

agacacaacc aacttccacc aagcaataag ggataagata gacaaggaag agaatctaca    10440

gaccccgggt ttacataaga aactaatgga agttttcaat gcattgaaac gacccgagtt    10500

agagtcctcc tatgacgctg tggaatggga ggaattggag agaggaataa acagaaaggg    10560

tgctgctggt ttctttgaac gcaaaaacat aggggagata ttggattcag agaaaaataa    10620

agtagaagag attattgaca atctgaaaaa gggtagaaat atcaaatact atgaaaccgc    10680

aatcccaaaa aatgaaaaga gggatgtcaa tgatgactgg accgcaggtg actttgtgga    10740

cgagaagaaa cccagagtca tacaataccc tgaagcaaaa acaaggctgg ccatcaccaa    10800

ggtgatgtat aagtgggtga agcagaagcc agtagtcata cccgggtatg aagggaagac    10860

acctctgttc caaatttttg acaaagtaaa gaaggaatgg gatcaattcc aaaatccagt    10920

ggcagtgagc ttcgacacta aggcgtggga cacccaggtg accacaaatg atctggagct    10980

gataaaggac atacaaaagt actacttcaa gaagaaatgg cataaattta ttgacaccct    11040

gactatgcat atgtcagaag tacccgtaat cactgctgat ggggaggtgt atataaggaa    11100

agggcaaaga ggtagtggac agcccgacac aagcgcaggc aacagcatgc taaatgtgtt    11160

aacaatggtt tatgccttct gcgaggccac aggggtaccc tacaagagtt ttgacagggt    11220

ggcaaaaatt catgtgtgcg gggacgatgg tttcctgatc acagagagag ctctcggcga    11280

gaaattcgca agcaagggag tccaaatcct gtatgaagct gggaagcccc agaagatcac    11340

tgaaggggac aaaatgaaag tggcctacca atttgatgat attgagtttt gctcccatac    11400

accaatacaa gtaaggtggt cagataacac ttctagctac atgccaggga gaaatacaac    11460

cacaatcctg gctaaaatgg ccacaaggtt agattccagt ggtgagaggg gtaccatagc    11520

gtacgagaaa gcagtagcat tcagcttcct gctaatgtat tcctggaacc cactaatcag    11580

aaggatttgc ttattggtac tatcaactga actgcaagtg aaaccaggga agtcaaccac    11640

ttactattat gaaggggacc cgatatctgc ctacaaggaa gtcatcggcc acaatctttt    11700

cgatctcaag agaacaagct tcgagaagct ggccaagtta aatctcagca tgtccgtact    11760

cggggcctgg actagacaca ccagcaaaag actactacaa gactgtgtca atatgggtgt    11820

taaagagggc aactggttag tcaatgcaga cagactggtg agtagtaaga ctggaaatag    11880

gtatgtacct ggagaaggcc acaccctgca agggagacat tatgaagaac tggtgttggc    11940

aagaaaacag atcaacagct tccaagggac agacaggtac aatctaggcc caatagtcaa    12000

catggtgtta aggaggctga gagtcatgat gatgaccctg atagggagag gggtatgagt    12060

gcgggtgacc cgcgatctgg acccgtcagt aggaccctat tgtagataac actaattttt    12120

tatttattta gatattacta tttatttatt tatttattta ttgaatgagt aagaactggt    12180

acaaactacc tcatgttacc acactacact cattttaaca gcactttagc tggaaggaaa    12240

attcctgacg tccacagttg gactaaggta atttcctaac ggccc                    12285


<210>  2
<211>  3180
<212>  PRT
<213>  Classical swine fever virus

<400>  2

Met Glu Leu Asn His Phe Glu Leu Leu Tyr Lys Thr Asn Lys Gln Lys 
1               5                   10                  15      


Pro Met Gly Val Glu Glu Pro Val Tyr Asp Val Thr Gly Arg Pro Leu 
            20                  25                  30          


Phe Gly Asp Pro Ser Glu Val His Pro Gln Ser Thr Leu Lys Leu Pro 
        35                  40                  45              


His Asp Arg Gly Arg Gly Asn Ile Lys Thr Thr Leu Lys Asn Leu Pro 
    50                  55                  60                  


Arg Arg Gly Asp Cys Arg Ser Gly Asn His Leu Gly Pro Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Val Lys Pro Gly Pro Val Phe Tyr Gln Asp Tyr Met Gly Pro 
                85                  90                  95      


Val Tyr His Arg Ala Pro Leu Glu Phe Phe Asp Glu Ala Gln Phe Cys 
            100                 105                 110         


Glu Val Thr Lys Arg Ile Gly Arg Val Thr Gly Ser Asp Gly Lys Leu 
        115                 120                 125             


Tyr His Ile Tyr Val Cys Ile Asp Gly Cys Ile Leu Leu Lys Leu Ala 
    130                 135                 140                 


Lys Arg Gly Glu Pro Arg Thr Leu Lys Trp Ile Arg Asn Leu Thr Asp 
145                 150                 155                 160 


Cys Pro Leu Trp Val Thr Ser Cys Ser Asp Asp Gly Ala Ser Ala Ser 
                165                 170                 175     


Lys Glu Lys Lys Pro Asp Arg Ile Asn Lys Gly Lys Leu Lys Ile Ala 
            180                 185                 190         


Pro Lys Glu His Glu Lys Asp Ser Arg Thr Lys Pro Pro Asp Ala Thr 
        195                 200                 205             


Ile Val Val Glu Gly Val Lys Tyr Gln Val Lys Lys Lys Gly Lys Val 
    210                 215                 220                 


Lys Gly Lys Asn Thr Gln Asp Gly Leu Tyr His Asn Lys Asn Lys Pro 
225                 230                 235                 240 


Pro Glu Ser Arg Lys Lys Leu Glu Lys Ala Leu Leu Ala Trp Ala Val 
                245                 250                 255     


Ile Ala Ile Met Leu Tyr Gln Pro Val Ala Ala Glu Asn Ile Thr Gln 
            260                 265                 270         


Trp Asn Leu Ser Asp Asn Gly Thr Asn Gly Ile Gln His Ala Met Tyr 
        275                 280                 285             


Leu Arg Gly Val Ser Arg Ser Leu His Gly Ile Trp Pro Glu Lys Ile 
    290                 295                 300                 


Cys Lys Gly Val Pro Thr Tyr Leu Ala Thr Asp Thr Glu Leu Arg Glu 
305                 310                 315                 320 


Ile Gln Gly Met Met Asp Ala Ser Glu Gly Thr Asn Tyr Thr Cys Cys 
                325                 330                 335     


Lys Leu Gln Arg His Glu Trp Asn Lys His Gly Trp Cys Asn Trp Tyr 
            340                 345                 350         


Asn Ile Asp Pro Trp Ile Gln Leu Met Asn Arg Thr Gln Ala Asn Leu 
        355                 360                 365             


Ala Glu Gly Pro Pro Ser Lys Glu Cys Ala Val Thr Cys Arg Tyr Asp 
    370                 375                 380                 


Lys Asn Ala Asp Ile Asn Val Val Thr Gln Ala Arg Asn Arg Pro Thr 
385                 390                 395                 400 


Thr Leu Thr Gly Cys Lys Lys Gly Lys Asn Phe Ser Phe Ala Gly Thr 
                405                 410                 415     


Val Ile Glu Gly Pro Cys Asn Phe Asn Val Ser Val Glu Asp Ile Leu 
            420                 425                 430         


Tyr Gly Asp His Glu Cys Gly Ser Leu Leu Gln Asp Thr Ala Leu Tyr 
        435                 440                 445             


Leu Val Asp Gly Met Thr Asn Thr Ile Glu Arg Ala Arg Gln Gly Ala 
    450                 455                 460                 


Ala Arg Val Thr Ser Trp Leu Gly Arg Gln Leu Arg Thr Ala Gly Lys 
465                 470                 475                 480 


Arg Leu Glu Gly Arg Ser Lys Thr Trp Phe Gly Ala Tyr Ala Leu Ser 
                485                 490                 495     


Pro Tyr Cys Asn Val Thr Ser Lys Ile Gly Tyr Ile Trp Tyr Thr Asn 
            500                 505                 510         


Asn Cys Thr Pro Ala Cys Leu Pro Lys Asn Thr Lys Ile Ile Gly Pro 
        515                 520                 525             



Gly Lys Phe Asp Thr Asn Ala Glu Asp Gly Lys Ile Leu His Glu Met 
    530                 535                 540                 


Gly Gly His Leu Ser Glu Phe Leu Leu Leu Ser Leu Val Val Leu Ser 
545                 550                 555                 560 


Asp Phe Ala Pro Glu Thr Ala Ser Ala Leu Tyr Leu Ile Leu His Tyr 
                565                 570                 575     


Val Ile Pro Gln Ser His Glu Glu Pro Glu Gly Cys Asp Thr Asn Gln 
            580                 585                 590         


Leu Asn Leu Thr Val Glu Leu Arg Thr Glu Asp Val Ile Pro Ser Ser 
        595                 600                 605             


Val Trp Asn Val Gly Lys Tyr Val Cys Val Arg Pro Asp Trp Trp Pro 
    610                 615                 620                 


Tyr Glu Thr Lys Val Ala Leu Leu Phe Glu Glu Ala Gly Gln Val Val 
625                 630                 635                 640 


Lys Leu Ala Leu Arg Ala Leu Arg Asp Leu Thr Arg Val Trp Asn Ser 
                645                 650                 655     


Ala Ser Thr Thr Ala Phe Leu Ile Cys Leu Ile Lys Val Leu Arg Gly 
            660                 665                 670         


Gln Val Val Gln Gly Val Ile Trp Leu Leu Leu Val Thr Gly Ala Gln 
        675                 680                 685             


Gly Arg Leu Ala Cys Lys Glu Asp His Arg Tyr Ala Ile Ser Thr Thr 
    690                 695                 700                 


Asn Glu Ile Gly Leu Leu Gly Ala Glu Gly Leu Thr Thr Thr Trp Lys 
705                 710                 715                 720 


Glu Tyr Asn His Asn Leu Gln Leu Asp Asp Gly Thr Val Lys Ala Ile 
                725                 730                 735     


Cys Met Ala Gly Ser Phe Lys Val Thr Ala Leu Asn Val Val Ser Arg 
            740                 745                 750         



Arg Tyr Leu Ala Ser Leu His Lys Asp Ala Leu Pro Thr Ser Val Thr 
        755                 760                 765             


Phe Glu Leu Leu Phe Asp Gly Thr Ser Pro Leu Thr Glu Glu Met Gly 
    770                 775                 780                 


Asp Asp Phe Gly Phe Gly Leu Cys Pro Tyr Asp Thr Ser Pro Val Val 
785                 790                 795                 800 


Lys Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu 
                805                 810                 815     


Val Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser 
            820                 825                 830         


Pro Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Arg Arg Glu Lys 
        835                 840                 845             


Pro Phe Pro Tyr Arg Arg Asp Cys Val Thr Thr Thr Val Glu Asn Glu 
    850                 855                 860                 


Asp Leu Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly 
865                 870                 875                 880 


Glu Pro Val Thr Tyr Thr Gly Gly Pro Val Lys Gln Cys Arg Trp Cys 
                885                 890                 895     


Gly Phe Asp Phe Asn Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly 
            900                 905                 910         


Lys Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Ile Val Asp Ser Thr 
        915                 920                 925             


Asp Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Ser His Glu 
    930                 935                 940                 


Cys Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Glu Arg 
945                 950                 955                 960 


Leu Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly 
                965                 970                 975     



Pro Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Ala Lys Thr Leu Arg 
            980                 985                 990         


Asn Arg Tyr Tyr Glu Pro Arg Asp  Ser Tyr Phe Gln Gln  Tyr Met Leu 
        995                 1000                 1005             


Lys Gly  Glu Tyr Gln Tyr Trp  Phe Asp Leu Asp Val  Thr Asp Arg 
    1010                 1015                 1020             


His Ser  Asp Tyr Phe Ala Glu  Phe Ile Val Leu Val  Val Val Ala 
    1025                 1030                 1035             


Leu Leu  Gly Gly Arg Tyr Val  Leu Trp Leu Ile Val  Thr Tyr Ile 
    1040                 1045                 1050             


Val Leu  Thr Glu Gln Leu Ala  Ala Gly Leu Gln Leu  Gly Gln Gly 
    1055                 1060                 1065             


Glu Val  Val Leu Ile Gly Asn  Leu Ile Thr His Thr  Asp Ile Glu 
    1070                 1075                 1080             


Val Val  Val Tyr Phe Leu Leu  Leu Tyr Leu Val Met  Arg Asp Glu 
    1085                 1090                 1095             


Pro Ile  Lys Lys Trp Ile Leu  Leu Leu Phe His Ala  Met Thr Asn 
    1100                 1105                 1110             


Asn Pro  Val Lys Thr Ile Thr  Val Ala Leu Leu Met  Val Ser Gly 
    1115                 1120                 1125             


Val Ala  Lys Gly Gly Lys Ile  Asp Gly Gly Trp Gln  Arg Leu Pro 
    1130                 1135                 1140             


Glu Thr  Asn Phe Asp Ile Gln  Leu Ala Leu Thr Val  Ile Val Val 
    1145                 1150                 1155             


Ala Val  Met Leu Leu Ala Lys  Lys Asp Pro Thr Thr  Val Pro Leu 
    1160                 1165                 1170             


Val Ile  Thr Val Ala Thr Leu  Arg Thr Ala Lys Ile  Thr Asn Gly 
    1175                 1180                 1185             



Leu Ser  Thr Asp Leu Ala Ile  Ala Thr Val Ser Thr  Ala Leu Leu 
    1190                 1195                 1200             


Thr Trp  Thr Tyr Ile Ser Asp  Tyr Tyr Lys Tyr Lys  Thr Leu Leu 
    1205                 1210                 1215             


Gln Tyr  Leu Ile Ser Thr Val  Thr Gly Ile Phe Leu  Ile Arg Val 
    1220                 1225                 1230             


Leu Lys  Gly Val Gly Glu Leu  Asp Leu His Thr Pro  Thr Leu Pro 
    1235                 1240                 1245             


Ser Tyr  Arg Pro Leu Phe Phe  Ile Leu Val Tyr Leu  Ile Ser Thr 
    1250                 1255                 1260             


Ala Val  Val Thr Arg Trp Asn  Leu Asp Ile Ala Gly  Leu Leu Leu 
    1265                 1270                 1275             


Gln Cys  Val Pro Thr Leu Leu  Met Val Phe Thr Met  Trp Ala Asp 
    1280                 1285                 1290             


Ile Leu  Thr Leu Ile Leu Ile  Leu Pro Thr Tyr Glu  Leu Thr Lys 
    1295                 1300                 1305             


Leu Tyr  Tyr Leu Lys Glu Val  Lys Ile Gly Ala Glu  Arg Gly Trp 
    1310                 1315                 1320             


Leu Trp  Lys Thr Asn Phe Lys  Arg Val Asn Asp Ile  Tyr Glu Val 
    1325                 1330                 1335             


Asp Gln  Ala Gly Glu Gly Val  Tyr Leu Phe Pro Ser  Lys Gln Lys 
    1340                 1345                 1350             


Thr Gly  Thr Ile Thr Gly Thr  Met Leu Pro Leu Ile  Lys Ala Ile 
    1355                 1360                 1365             


Leu Ile  Ser Cys Ile Ser Asn  Lys Trp Gln Phe Ile  Tyr Leu Leu 
    1370                 1375                 1380             


Tyr Leu  Ile Phe Glu Val Ser  Tyr Tyr Leu His Lys  Lys Ile Ile 
    1385                 1390                 1395             



Asp Glu  Ile Ala Gly Gly Thr  Asn Phe Ile Ser Arg  Leu Val Ala 
    1400                 1405                 1410             


Ala Leu  Ile Glu Ala Asn Trp  Ala Phe Asp Asn Glu  Glu Val Arg 
    1415                 1420                 1425             


Gly Leu  Lys Lys Phe Phe Leu  Leu Ser Ser Arg Val  Lys Glu Leu 
    1430                 1435                 1440             


Ile Ile  Lys His Lys Val Arg  Asn Glu Val Met Val  His Trp Phe 
    1445                 1450                 1455             


Gly Asp  Glu Glu Val Tyr Gly  Met Pro Lys Leu Val  Gly Leu Val 
    1460                 1465                 1470             


Lys Ala  Ala Thr Leu Ser Lys  Asn Lys His Cys Ile  Leu Cys Thr 
    1475                 1480                 1485             


Val Cys  Glu Asn Arg Glu Trp  Arg Gly Glu Thr Cys  Pro Lys Cys 
    1490                 1495                 1500             


Gly Arg  Phe Gly Pro Pro Val  Thr Cys Gly Met Thr  Leu Ala Asp 
    1505                 1510                 1515             


Phe Glu  Glu Lys His Tyr Lys  Arg Ile Phe Phe Arg  Glu Asp Gln 
    1520                 1525                 1530             


Ser Glu  Gly Pro Val Arg Glu  Glu Tyr Ala Gly Tyr  Leu Gln Tyr 
    1535                 1540                 1545             


Arg Ala  Arg Gly Gln Leu Phe  Leu Arg Asn Leu Pro  Val Leu Ala 
    1550                 1555                 1560             


Thr Lys  Val Lys Met Leu Leu  Val Gly Asn Leu Gly  Thr Glu Val 
    1565                 1570                 1575             


Gly Asp  Leu Glu His Leu Gly  Trp Val Leu Arg Gly  Pro Ala Val 
    1580                 1585                 1590             


Cys Lys  Lys Val Thr Glu His  Glu Lys Cys Thr Thr  Ser Ile Met 
    1595                 1600                 1605             



Asp Lys  Leu Thr Ala Phe Phe  Gly Val Met Pro Arg  Gly Thr Thr 
    1610                 1615                 1620             


Pro Arg  Ala Pro Val Arg Phe  Pro Thr Ser Leu Leu  Lys Ile Arg 
    1625                 1630                 1635             


Arg Gly  Leu Glu Thr Gly Trp  Ala Tyr Thr His Gln  Gly Gly Ile 
    1640                 1645                 1650             


Ser Ser  Val Asp His Val Thr  Cys Gly Lys Asp Leu  Leu Val Cys 
    1655                 1660                 1665             


Asp Thr  Met Gly Arg Thr Arg  Val Val Cys Gln Ser  Asn Asn Lys 
    1670                 1675                 1680             


Met Thr  Asp Glu Ser Glu Tyr  Gly Val Lys Thr Asp  Ser Gly Cys 
    1685                 1690                 1695             


Pro Glu  Gly Ala Arg Cys Tyr  Val Phe Asn Pro Glu  Ala Val Asn 
    1700                 1705                 1710             


Ile Ser  Gly Thr Lys Gly Ala  Met Val His Leu Gln  Lys Thr Gly 
    1715                 1720                 1725             


Gly Glu  Phe Thr Cys Val Thr  Ala Ser Gly Thr Pro  Ala Phe Phe 
    1730                 1735                 1740             


Asp Leu  Lys Asn Leu Lys Gly  Trp Ser Gly Leu Pro  Ile Phe Glu 
    1745                 1750                 1755             


Ala Ser  Ser Gly Arg Val Val  Gly Arg Val Lys Val  Gly Lys Asn 
    1760                 1765                 1770             


Glu Asp  Ser Lys Pro Thr Lys  Leu Met Ser Gly Ile  Gln Thr Val 
    1775                 1780                 1785             


Ser Lys  Ser Thr Thr Asp Leu  Thr Glu Met Val Lys  Lys Ile Thr 
    1790                 1795                 1800             


Thr Met  Asn Arg Gly Glu Phe  Arg Gln Ile Thr Leu  Ala Thr Gly 
    1805                 1810                 1815             



Ala Gly  Lys Thr Thr Glu Leu  Pro Arg Ser Val Ile  Glu Glu Ile 
    1820                 1825                 1830             


Gly Arg  His Lys Arg Val Leu  Val Leu Ile Pro Leu  Arg Ala Ala 
    1835                 1840                 1845             


Ala Glu  Ser Val Tyr Gln Tyr  Met Arg Gln Lys His  Pro Ser Ile 
    1850                 1855                 1860             


Ala Phe  Asn Leu Arg Ile Gly  Glu Met Lys Glu Gly  Asp Met Ala 
    1865                 1870                 1875             


Thr Gly  Ile Thr Tyr Ala Ser  Tyr Gly Tyr Phe Cys  Gln Met Pro 
    1880                 1885                 1890             


Gln Pro  Lys Leu Arg Ala Ala  Met Val Glu Tyr Ser  Phe Ile Phe 
    1895                 1900                 1905             


Leu Asp  Glu Tyr His Cys Ala  Thr Pro Glu Gln Leu  Ala Ile Met 
    1910                 1915                 1920             


Gly Lys  Ile His Arg Phe Ser  Glu Asn Leu Arg Val  Val Ala Met 
    1925                 1930                 1935             


Thr Ala  Thr Pro Ala Gly Thr  Val Thr Thr Thr Gly  Gln Lys His 
    1940                 1945                 1950             


Pro Ile  Glu Glu Tyr Ile Ala  Pro Glu Val Met Lys  Gly Glu Asp 
    1955                 1960                 1965             


Leu Gly  Ser Glu Tyr Leu Asp  Ile Ala Gly Leu Lys  Ile Pro Val 
    1970                 1975                 1980             


Glu Glu  Met Lys Ser Asn Met  Leu Val Phe Val Pro  Thr Arg Asn 
    1985                 1990                 1995             


Met Ala  Val Glu Thr Ala Lys  Lys Leu Lys Ala Lys  Gly Tyr Asn 
    2000                 2005                 2010             


Ser Gly  Tyr Tyr Tyr Ser Gly  Glu Asp Pro Ser Asn  Leu Arg Val 
    2015                 2020                 2025             



Val Thr  Ser Gln Ser Pro Tyr  Val Val Val Ala Thr  Asn Ala Ile 
    2030                 2035                 2040             


Glu Ser  Gly Val Thr Leu Pro  Asp Leu Asp Val Val  Val Asp Thr 
    2045                 2050                 2055             


Gly Leu  Lys Cys Glu Lys Arg  Ile Arg Leu Ser Pro  Lys Met Pro 
    2060                 2065                 2070             


Phe Ile  Val Thr Gly Leu Lys  Arg Met Ala Val Thr  Ile Gly Glu 
    2075                 2080                 2085             


Gln Ala  Gln Arg Arg Gly Arg  Val Gly Arg Val Lys  Pro Gly Arg 
    2090                 2095                 2100             


Tyr Tyr  Arg Ser Gln Glu Thr  Pro Val Gly Ser Lys  Asp Tyr His 
    2105                 2110                 2115             


Tyr Asp  Leu Leu Gln Ala Gln  Arg Tyr Gly Ile Glu  Asp Gly Ile 
    2120                 2125                 2130             


Asn Ile  Thr Lys Ser Phe Arg  Glu Met Asn Tyr Asp  Trp Ser Leu 
    2135                 2140                 2145             


Tyr Glu  Glu Asp Ser Leu Met  Ile Thr Gln Leu Glu  Ile Leu Asn 
    2150                 2155                 2160             


Asn Leu  Leu Ile Ser Glu Glu  Leu Pro Met Ala Val  Lys Asn Ile 
    2165                 2170                 2175             


Met Ala  Arg Thr Asp His Pro  Glu Pro Ile Gln Leu  Ala Tyr Asn 
    2180                 2185                 2190             


Ser Tyr  Glu Thr Gln Val Pro  Val Leu Phe Pro Lys  Ile Lys Asn 
    2195                 2200                 2205             


Gly Glu  Val Thr Asp Ser Tyr  Asp Asn Tyr Thr Phe  Leu Asn Ala 
    2210                 2215                 2220             


Arg Lys  Leu Gly Asp Asp Val  Pro Pro Tyr Val Tyr  Ala Thr Glu 
    2225                 2230                 2235             



Asp Glu  Asp Leu Ala Val Glu  Leu Leu Gly Leu Asp  Trp Pro Asp 
    2240                 2245                 2250             


Pro Gly  Asn Gln Gly Thr Val  Glu Ala Gly Arg Ala  Leu Lys Gln 
    2255                 2260                 2265             


Val Val  Gly Leu Ser Thr Ala  Glu Asn Ala Leu Leu  Val Ala Leu 
    2270                 2275                 2280             


Phe Gly  Tyr Val Gly Tyr Gln  Ala Leu Ser Lys Arg  His Ile Pro 
    2285                 2290                 2295             


Val Val  Thr Asp Ile Tyr Ser  Ile Glu Asp His Arg  Leu Glu Asp 
    2300                 2305                 2310             


Thr Thr  His Leu Gln Tyr Ala  Pro Asn Ala Ile Lys  Thr Glu Gly 
    2315                 2320                 2325             


Lys Glu  Thr Glu Leu Lys Glu  Leu Ala Gln Gly Asp  Val Gln Arg 
    2330                 2335                 2340             


Cys Met  Glu Ala Met Thr Asn  Tyr Ala Arg Asp Gly  Ile Gln Phe 
    2345                 2350                 2355             


Met Lys  Ser Gln Ala Leu Lys  Val Lys Glu Thr Pro  Thr Tyr Lys 
    2360                 2365                 2370             


Glu Thr  Met Asp Thr Val Ala  Asp Tyr Val Lys Lys  Phe Met Glu 
    2375                 2380                 2385             


Ala Leu  Ala Asp Ser Lys Glu  Asp Ile Ile Lys Tyr  Gly Leu Trp 
    2390                 2395                 2400             


Gly Thr  His Thr Thr Leu Tyr  Lys Ser Ile Gly Ala  Arg Leu Gly 
    2405                 2410                 2415             


Asn Glu  Thr Ala Phe Ala Thr  Leu Val Val Lys Trp  Leu Ala Phe 
    2420                 2425                 2430             


Gly Gly  Glu Ser Ile Ala Asp  His Val Lys Gln Ala  Ala Thr Asp 
    2435                 2440                 2445             



Leu Val  Val Tyr Tyr Ile Ile  Asn Arg Pro Gln Phe  Pro Gly Asp 
    2450                 2455                 2460             


Thr Glu  Thr Gln Gln Glu Gly  Arg Lys Phe Val Ala  Ser Leu Leu 
    2465                 2470                 2475             


Val Ser  Ala Leu Ala Thr Tyr  Thr Tyr Lys Ser Trp  Asn Tyr Asn 
    2480                 2485                 2490             


Asn Leu  Ser Lys Ile Val Glu  Pro Ala Leu Ala Thr  Leu Pro Tyr 
    2495                 2500                 2505             


Ala Ala  Thr Ala Leu Lys Leu  Phe Ala Pro Thr Arg  Leu Glu Ser 
    2510                 2515                 2520             


Val Val  Ile Leu Ser Thr Ala  Ile Tyr Lys Thr Tyr  Leu Ser Ile 
    2525                 2530                 2535             


Arg Arg  Gly Lys Ser Asp Gly  Leu Leu Gly Thr Gly  Val Ser Ala 
    2540                 2545                 2550             


Ala Met  Glu Ile Met Ser Gln  Asn Pro Val Ser Ala  Ala Ala Ala 
    2555                 2560                 2565             


Val Met  Leu Gly Val Gly Ala  Val Ala Ala His Asn  Ala Ile Glu 
    2570                 2575                 2580             


Ala Ser  Glu Gln Lys Arg Thr  Leu Leu Met Lys Val  Phe Val Lys 
    2585                 2590                 2595             


Asn Phe  Leu Asp Gln Ala Ala  Thr Asp Glu Leu Val  Lys Glu Ser 
    2600                 2605                 2610             


Pro Glu  Lys Ile Ile Met Ala  Leu Phe Glu Ala Val  Gln Thr Val 
    2615                 2620                 2625             


Gly Asn  Pro Leu Arg Leu Val  Tyr His Leu Tyr Gly  Val Phe Tyr 
    2630                 2635                 2640             


Lys Gly  Trp Glu Ala Lys Glu  Leu Ala Gln Arg Thr  Ala Gly Arg 
    2645                 2650                 2655             



Asn Leu  Phe Thr Leu Ile Met  Phe Glu Ala Val Glu  Leu Leu Gly 
    2660                 2665                 2670             


Val Asp  Ser Glu Gly Lys Ile  Arg Gln Leu Ser Ser  Asn Tyr Ile 
    2675                 2680                 2685             


Leu Glu  Leu Leu Tyr Lys Phe  Arg Asp Ser Ile Lys  Ser Ser Val 
    2690                 2695                 2700             


Arg Gln  Met Ala Ile Ser Trp  Ala Pro Ala Pro Phe  Ser Cys Asp 
    2705                 2710                 2715             


Trp Thr  Pro Thr Asp Asp Arg  Ile Gly Leu Pro Gln  Asp Asn Phe 
    2720                 2725                 2730             


Leu Arg  Val Glu Thr Lys Cys  Pro Cys Gly Tyr Lys  Met Lys Ala 
    2735                 2740                 2745             


Val Lys  Asn Cys Ala Gly Glu  Leu Arg Leu Leu Glu  Glu Glu Gly 
    2750                 2755                 2760             


Ser Phe  Leu Cys Arg Asn Lys  Phe Gly Arg Gly Ser  Arg Asn Tyr 
    2765                 2770                 2775             


Arg Val  Thr Lys Tyr Tyr Asp  Asp Asn Leu Ser Glu  Ile Lys Pro 
    2780                 2785                 2790             


Val Ile  Arg Met Glu Gly His  Val Glu Leu Tyr Tyr  Lys Gly Ala 
    2795                 2800                 2805             


Thr Ile  Lys Leu Asp Phe Asn  Asn Ser Lys Thr Ile  Leu Ala Thr 
    2810                 2815                 2820             


Asp Lys  Trp Glu Val Asp His  Ser Thr Leu Val Arg  Val Leu Lys 
    2825                 2830                 2835             


Arg His  Thr Gly Ala Gly Tyr  Arg Gly Ala Tyr Leu  Gly Glu Lys 
    2840                 2845                 2850             


Pro Asn  His Lys His Leu Ile  Glu Arg Asp Cys Ala  Thr Ile Thr 
    2855                 2860                 2865             



Lys Asp  Lys Val Cys Phe Leu  Lys Met Lys Arg Gly  Cys Ala Phe 
    2870                 2875                 2880             


Thr Tyr  Asp Leu Ser Leu His  Asn Leu Thr Arg Leu  Ile Glu Leu 
    2885                 2890                 2895             


Val His  Lys Asn Asn Leu Glu  Asp Lys Glu Ile Pro  Ala Val Thr 
    2900                 2905                 2910             


Val Thr  Thr Trp Leu Ala Tyr  Thr Phe Val Asn Glu  Asp Ile Gly 
    2915                 2920                 2925             


Thr Ile  Lys Pro Ala Phe Gly  Glu Lys Ile Thr Pro  Glu Met Gln 
    2930                 2935                 2940             


Glu Glu  Ile Thr Leu Gln Pro  Ala Val Val Val Asp  Ala Thr Asp 
    2945                 2950                 2955             


Val Thr  Val Thr Val Val Gly  Glu Thr Pro Thr Met  Thr Thr Gly 
    2960                 2965                 2970             


Glu Thr  Pro Thr Thr Phe Thr  Ser Ser Gly Pro Asp  Pro Lys Gly 
    2975                 2980                 2985             


Gln Gln  Val Leu Lys Leu Gly  Val Gly Glu Gly Gln  Tyr Pro Gly 
    2990                 2995                 3000             


Thr Asn  Pro Gln Arg Ala Ser  Leu His Glu Ala Ile  Gln Ser Ala 
    3005                 3010                 3015             


Asp Glu  Arg Pro Ser Val Leu  Ile Leu Gly Ser Asp  Lys Ala Thr 
    3020                 3025                 3030             


Ser Asn  Arg Val Lys Thr Val  Lys Asn Val Lys Val  Tyr Arg Gly 
    3035                 3040                 3045             


Arg Asp  Pro Leu Glu Val Arg  Asp Met Met Arg Arg  Gly Lys Ile 
    3050                 3055                 3060             


Leu Val  Ile Ala Leu Ser Arg  Val Asp Asn Ala Leu  Leu Lys Phe 
    3065                 3070                 3075             



Val Asp  Tyr Lys Gly Thr Phe  Leu Thr Arg Glu Thr  Leu Glu Ala 
    3080                 3085                 3090             


Leu Ser  Leu Gly Arg Pro Lys  Lys Lys Asn Ile Thr  Lys Ala Glu 
    3095                 3100                 3105             


Ala Gln  Trp Leu Leu Arg Leu  Glu Asp Gln Met Glu  Glu Leu Pro 
    3110                 3115                 3120             


Asp Trp  Phe Ala Ala Gly Glu  Pro Ile Phe Leu Glu  Ala Asn Ile 
    3125                 3130                 3135             


Lys His  Asp Arg Tyr His Leu  Val Gly Asp Ile Ala  Thr Ile Lys 
    3140                 3145                 3150             


Glu Lys  Ala Lys Gln Leu Gly  Ala Thr Asp Ser Thr  Lys Ile Ser 
    3155                 3160                 3165             


Lys Glu  Val Gly Ala Lys Val  Tyr Ser Met Lys Leu  
    3170                 3175                 3180 


<210>  3
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  3
gtcatactga gtaccgcagc cgccgcaacc tacctatcaa tcagg                       45


<210>  4
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  4
tcacaaaacc cagtatctgc ggctgcagcg gtcatgctag gggtg                       45


