                         SEQUENCE LISTING



<110>  ZIRUS, INC.

       Vanderbilt University

 

<120>  MAMMALIAN GENES INVOLVED IN INFECTION



<130>  01123.0016P1



<150>  US 61/203,213

<151>  2008-12-18



<160>  2017  



<170>  PatentIn version 3.5



<210>  1

<211>  1624

<212>  DNA

<213>  Homo sapiens



<400>  1

gggaggggcg gggcctccgc caccacctca gctgcggacc gaggcgagat ggcggccacc       60



gagggggtcg gggaggctgc gcaagggggc gagcccgggc agccggcgca acccccgccc      120



cagccgcacc caccgccgcc ccagcagcag cacaaggaag agatggcggc cgaggctggg      180



gaagccgtgg cgtcccccat ggacgacggg tttgtgagcc tggactcgcc ctcctatgtc      240



ctgtacagtt agagatgttt atgattactt ccgagctgtc ctgcagcgtg atgaaagaag      300



tgaacgagct tttaagctaa cccgggatgc tattgagtta aatgcagcca attatacagt      360



gtggcatttc cggagagttc ttttgaagtc acttcagaag gatctacatg aggaaatgaa      420



ctacatcact gcaataattg aggagcagcc caaaaactat caagtttggc atcataggcg      480



agtattagtg gaatggctaa gagatccatc tcaggagctt gaatttattg ctgatattct      540



taatcaggat gcaaagaatt atcatgcctg gcagcatcga caatgggtta ttcaggaatt      600



taaactttgg gataatgagc tgcagtatgt ggaccaactt ctgaaagagg atgtgagaaa      660



taactctgtc tggaaccaaa gatacttcgt tatttctaac accactggct acaatgatcg      720



tgctgtattg gagagagaag tccaatacac tctggaaatg attaaactag taccacataa      780



tgaaagtgca tggaactatt tgaaagggat tttgcaggat cgtggtcttt ccaaatatcc      840



taatctgtta aatcaattac ttgatttaca accaagtcat agttccccct acctaattgc      900



ctttcttgtg gatatctatg aagacatgct agaaaatcag tgtgacaata aggaagacat      960



tcttaataaa gcattagagt tatgtgaaat cctagctaaa gaaaaggaca ctataagaaa     1020



ggaatattgg agatacattg gaagatccct tcaaagcaaa cacagcacag aaaatgactc     1080



accaacaaat gtacagcaat aacaccatcc agaagaactt gatggaatgc ttttattttt     1140



tattaaggga ccctgcagga gtttcacacg agagtggtcc ttccctttgc ctgtggtgta     1200



aaagtgcatc acacaggtat tgctttttaa caagaactga tgctccttgg gtgctgctgc     1260



tactcagact agctctaagt aatgtgattc ttctaaagca aagtcattgg atgggaggag     1320



gaagaaaaag tcccataaag gaacttttgt agtcttatca acatataatc taatccctta     1380



gcatcagctc ctccctcagt ggtacatgcg tcaagatttg tagcagtaat aactgcaggt     1440



cacttgtatg taatggatgt gaggtagccg aagtttggtt cagtaagcag ggaatacagt     1500



cgttccatca gagctggtct gcacactcac attatcttgc tatcactgta accaactaat     1560



gccaaaagaa cggttttgta ataaaattat agctgtatct aaaaacaaaa aaaaaaaaaa     1620



aaaa                                                                  1624





<210>  2

<211>  288

<212>  PRT

<213>  Homo sapiens



<400>  2



Met Ser Cys Thr Val Arg Asp Val Tyr Asp Tyr Phe Arg Ala Val Leu 

1               5                   10                  15      





Gln Arg Asp Glu Arg Ser Glu Arg Ala Phe Lys Leu Thr Arg Asp Ala 

            20                  25                  30          





Ile Glu Leu Asn Ala Ala Asn Tyr Thr Val Trp His Phe Arg Arg Val 

        35                  40                  45              





Leu Leu Lys Ser Leu Gln Lys Asp Leu His Glu Glu Met Asn Tyr Ile 

    50                  55                  60                  





Thr Ala Ile Ile Glu Glu Gln Pro Lys Asn Tyr Gln Val Trp His His 

65                  70                  75                  80  





Arg Arg Val Leu Val Glu Trp Leu Arg Asp Pro Ser Gln Glu Leu Glu 

                85                  90                  95      





Phe Ile Ala Asp Ile Leu Asn Gln Asp Ala Lys Asn Tyr His Ala Trp 

            100                 105                 110         





Gln His Arg Gln Trp Val Ile Gln Glu Phe Lys Leu Trp Asp Asn Glu 

        115                 120                 125             





Leu Gln Tyr Val Asp Gln Leu Leu Lys Glu Asp Val Arg Asn Asn Ser 

    130                 135                 140                 





Val Trp Asn Gln Arg Tyr Phe Val Ile Ser Asn Thr Thr Gly Tyr Asn 

145                 150                 155                 160 





Asp Arg Ala Val Leu Glu Arg Glu Val Gln Tyr Thr Leu Glu Met Ile 

                165                 170                 175     





Lys Leu Val Pro His Asn Glu Ser Ala Trp Asn Tyr Leu Lys Gly Ile 

            180                 185                 190         





Leu Gln Asp Arg Gly Leu Ser Lys Tyr Pro Asn Leu Leu Asn Gln Leu 

        195                 200                 205             





Leu Asp Leu Gln Pro Ser His Ser Ser Pro Tyr Leu Ile Ala Phe Leu 

    210                 215                 220                 





Val Asp Ile Tyr Glu Asp Met Leu Glu Asn Gln Cys Asp Asn Lys Glu 

225                 230                 235                 240 





Asp Ile Leu Asn Lys Ala Leu Glu Leu Cys Glu Ile Leu Ala Lys Glu 

                245                 250                 255     





Lys Asp Thr Ile Arg Lys Glu Tyr Trp Arg Tyr Ile Gly Arg Ser Leu 

            260                 265                 270         





Gln Ser Lys His Ser Thr Glu Asn Asp Ser Pro Thr Asn Val Gln Gln 

        275                 280                 285             





<210>  3

<211>  1509

<212>  DNA

<213>  Homo sapiens



<400>  3

gggaggggcg gggcctccgc caccacctca gctgcggacc gaggcgagat ggcggccacc       60



gagggggtcg gggaggctgc gcaagggggc gagcccgggc agccggcgca acccccgccc      120



cagccgcacc caccgccgcc ccagcagcag cacaaggaag agatggcggc cgaggctggg      180



gaagccgtgg cgtcccccat ggacgacggg tttgtgagcc tggactcgcc ctcctatgtc      240



ctgtacaggc atttccggag agttcttttg aagtcacttc agaaggatct acatgaggaa      300



atgaactaca tcactgcaat aattgaggag cagcccaaaa actatcaagt ttggcatcat      360



aggcgagtat tagtggaatg gctaagagat ccatctcagg agcttgaatt tattgctgat      420



attcttaatc aggatgcaaa gaattatcat gcctggcagc atcgacaatg ggttattcag      480



gaatttaaac tttgggataa tgagctgcag tatgtggacc aacttctgaa agaggatgtg      540



agaaataact ctgtctggaa ccaaagatac ttcgttattt ctaacaccac tggctacaat      600



gatcgtgctg tattggagag agaagtccaa tacactctgg aaatgattaa actagtacca      660



cataatgaaa gtgcatggaa ctatttgaaa gggattttgc aggatcgtgg tctttccaaa      720



tatcctaatc tgttaaatca attacttgat ttacaaccaa gtcatagttc cccctaccta      780



attgcctttc ttgtggatat ctatgaagac atgctagaaa atcagtgtga caataaggaa      840



gacattctta ataaagcatt agagttatgt gaaatcctag ctaaagaaaa ggacactata      900



agaaaggaat attggagata cattggaaga tcccttcaaa gcaaacacag cacagaaaat      960



gactcaccaa caaatgtaca gcaataacac catccagaag aacttgatgg aatgctttta     1020



ttttttatta agggaccctg caggagtttc acacgagagt ggtccttccc tttgcctgtg     1080



gtgtaaaagt gcatcacaca ggtattgctt tttaacaaga actgatgctc cttgggtgct     1140



gctgctactc agactagctc taagtaatgt gattcttcta aagcaaagtc attggatggg     1200



aggaggaaga aaaagtccca taaaggaact tttgtagtct tatcaacata taatctaatc     1260



ccttagcatc agctcctccc tcagtggtac atgcgtcaag atttgtagca gtaataactg     1320



caggtcactt gtatgtaatg gatgtgaggt agccgaagtt tggttcagta agcagggaat     1380



acagtcgttc catcagagct ggtctgcaca ctcacattat cttgctatca ctgtaaccaa     1440



ctaatgccaa aagaacggtt ttgtaataaa attatagctg tatctaaaaa caaaaaaaaa     1500



aaaaaaaaa                                                             1509





<210>  4

<211>  312

<212>  PRT

<213>  Homo sapiens



<400>  4



Met Ala Ala Thr Glu Gly Val Gly Glu Ala Ala Gln Gly Gly Glu Pro 

1               5                   10                  15      





Gly Gln Pro Ala Gln Pro Pro Pro Gln Pro His Pro Pro Pro Pro Gln 

            20                  25                  30          





Gln Gln His Lys Glu Glu Met Ala Ala Glu Ala Gly Glu Ala Val Ala 

        35                  40                  45              





Ser Pro Met Asp Asp Gly Phe Val Ser Leu Asp Ser Pro Ser Tyr Val 

    50                  55                  60                  





Leu Tyr Arg His Phe Arg Arg Val Leu Leu Lys Ser Leu Gln Lys Asp 

65                  70                  75                  80  





Leu His Glu Glu Met Asn Tyr Ile Thr Ala Ile Ile Glu Glu Gln Pro 

                85                  90                  95      





Lys Asn Tyr Gln Val Trp His His Arg Arg Val Leu Val Glu Trp Leu 

            100                 105                 110         





Arg Asp Pro Ser Gln Glu Leu Glu Phe Ile Ala Asp Ile Leu Asn Gln 

        115                 120                 125             





Asp Ala Lys Asn Tyr His Ala Trp Gln His Arg Gln Trp Val Ile Gln 

    130                 135                 140                 





Glu Phe Lys Leu Trp Asp Asn Glu Leu Gln Tyr Val Asp Gln Leu Leu 

145                 150                 155                 160 





Lys Glu Asp Val Arg Asn Asn Ser Val Trp Asn Gln Arg Tyr Phe Val 

                165                 170                 175     





Ile Ser Asn Thr Thr Gly Tyr Asn Asp Arg Ala Val Leu Glu Arg Glu 

            180                 185                 190         





Val Gln Tyr Thr Leu Glu Met Ile Lys Leu Val Pro His Asn Glu Ser 

        195                 200                 205             





Ala Trp Asn Tyr Leu Lys Gly Ile Leu Gln Asp Arg Gly Leu Ser Lys 

    210                 215                 220                 





Tyr Pro Asn Leu Leu Asn Gln Leu Leu Asp Leu Gln Pro Ser His Ser 

225                 230                 235                 240 





Ser Pro Tyr Leu Ile Ala Phe Leu Val Asp Ile Tyr Glu Asp Met Leu 

                245                 250                 255     





Glu Asn Gln Cys Asp Asn Lys Glu Asp Ile Leu Asn Lys Ala Leu Glu 

            260                 265                 270         





Leu Cys Glu Ile Leu Ala Lys Glu Lys Asp Thr Ile Arg Lys Glu Tyr 

        275                 280                 285             





Trp Arg Tyr Ile Gly Arg Ser Leu Gln Ser Lys His Ser Thr Glu Asn 

    290                 295                 300                 





Asp Ser Pro Thr Asn Val Gln Gln 

305                 310         





<210>  5

<211>  1710

<212>  DNA

<213>  Homo sapiens



<400>  5

gggaggggcg gggcctccgc caccacctca gctgcggacc gaggcgagat ggcggccacc       60



gagggggtcg gggaggctgc gcaagggggc gagcccgggc agccggcgca acccccgccc      120



cagccgcacc caccgccgcc ccagcagcag cacaaggaag agatggcggc cgaggctggg      180



gaagccgtgg cgtcccccat ggacgacggg tttgtgagcc tggactcgcc ctcctatgtc      240



ctgtacaggg acagagcaga atgggctgat atagatccgg tgccgcagaa tgatggcccc      300



aatcccgtgg tccagatcat ttatagtgac aaatttagag atgtttatga ttacttccga      360



gctgtcctgc agcgtgatga aagaagtgaa cgagctttta agctaacccg ggatgctatt      420



gagttaaatg cagccaatta tacagtgtgg catttccgga gagttctttt gaagtcactt      480



cagaaggatc tacatgagga aatgaactac atcactgcaa taattgagga gcagcccaaa      540



aactatcaag tttggcatca taggcgagta ttagtggaat ggctaagaga tccatctcag      600



gagcttgaat ttattgctga tattcttaat caggatgcaa agaattatca tgcctggcag      660



catcgacaat gggttattca ggaatttaaa ctttgggata atgagctgca gtatgtggac      720



caacttctga aagaggatgt gagaaataac tctgtctgga accaaagata cttcgttatt      780



tctaacacca ctggctacaa tgatcgtgct gtattggaga gagaagtcca atacactctg      840



gaaatgatta aactagtacc acataatgaa agtgcatgga actatttgaa agggattttg      900



caggatcgtg gtctttccaa atatcctaat ctgttaaatc aattacttga tttacaacca      960



agtcatagtt ccccctacct aattgccttt cttgtggata tctatgaaga catgctagaa     1020



aatcagtgtg acaataagga agacattctt aataaagcat tagagttatg tgaaatccta     1080



gctaaagaaa aggacactat aagaaaggaa tattggagat acattggaag atcccttcaa     1140



agcaaacaca gcacagaaaa tgactcacca acaaatgtac agcaataaca ccatccagaa     1200



gaacttgatg gaatgctttt attttttatt aagggaccct gcaggagttt cacacgagag     1260



tggtccttcc ctttgcctgt ggtgtaaaag tgcatcacac aggtattgct ttttaacaag     1320



aactgatgct ccttgggtgc tgctgctact cagactagct ctaagtaatg tgattcttct     1380



aaagcaaagt cattggatgg gaggaggaag aaaaagtccc ataaaggaac ttttgtagtc     1440



ttatcaacat ataatctaat cccttagcat cagctcctcc ctcagtggta catgcgtcaa     1500



gatttgtagc agtaataact gcaggtcact tgtatgtaat ggatgtgagg tagccgaagt     1560



ttggttcagt aagcagggaa tacagtcgtt ccatcagagc tggtctgcac actcacatta     1620



tcttgctatc actgtaacca actaatgcca aaagaacggt tttgtaataa aattatagct     1680



gtatctaaaa acaaaaaaaa aaaaaaaaaa                                      1710





<210>  6

<211>  379

<212>  PRT

<213>  Homo sapiens



<400>  6



Met Ala Ala Thr Glu Gly Val Gly Glu Ala Ala Gln Gly Gly Glu Pro 

1               5                   10                  15      





Gly Gln Pro Ala Gln Pro Pro Pro Gln Pro His Pro Pro Pro Pro Gln 

            20                  25                  30          





Gln Gln His Lys Glu Glu Met Ala Ala Glu Ala Gly Glu Ala Val Ala 

        35                  40                  45              





Ser Pro Met Asp Asp Gly Phe Val Ser Leu Asp Ser Pro Ser Tyr Val 

    50                  55                  60                  





Leu Tyr Arg Asp Arg Ala Glu Trp Ala Asp Ile Asp Pro Val Pro Gln 

65                  70                  75                  80  





Asn Asp Gly Pro Asn Pro Val Val Gln Ile Ile Tyr Ser Asp Lys Phe 

                85                  90                  95      





Arg Asp Val Tyr Asp Tyr Phe Arg Ala Val Leu Gln Arg Asp Glu Arg 

            100                 105                 110         





Ser Glu Arg Ala Phe Lys Leu Thr Arg Asp Ala Ile Glu Leu Asn Ala 

        115                 120                 125             





Ala Asn Tyr Thr Val Trp His Phe Arg Arg Val Leu Leu Lys Ser Leu 

    130                 135                 140                 





Gln Lys Asp Leu His Glu Glu Met Asn Tyr Ile Thr Ala Ile Ile Glu 

145                 150                 155                 160 





Glu Gln Pro Lys Asn Tyr Gln Val Trp His His Arg Arg Val Leu Val 

                165                 170                 175     





Glu Trp Leu Arg Asp Pro Ser Gln Glu Leu Glu Phe Ile Ala Asp Ile 

            180                 185                 190         





Leu Asn Gln Asp Ala Lys Asn Tyr His Ala Trp Gln His Arg Gln Trp 

        195                 200                 205             





Val Ile Gln Glu Phe Lys Leu Trp Asp Asn Glu Leu Gln Tyr Val Asp 

    210                 215                 220                 





Gln Leu Leu Lys Glu Asp Val Arg Asn Asn Ser Val Trp Asn Gln Arg 

225                 230                 235                 240 





Tyr Phe Val Ile Ser Asn Thr Thr Gly Tyr Asn Asp Arg Ala Val Leu 

                245                 250                 255     





Glu Arg Glu Val Gln Tyr Thr Leu Glu Met Ile Lys Leu Val Pro His 

            260                 265                 270         





Asn Glu Ser Ala Trp Asn Tyr Leu Lys Gly Ile Leu Gln Asp Arg Gly 

        275                 280                 285             





Leu Ser Lys Tyr Pro Asn Leu Leu Asn Gln Leu Leu Asp Leu Gln Pro 

    290                 295                 300                 





Ser His Ser Ser Pro Tyr Leu Ile Ala Phe Leu Val Asp Ile Tyr Glu 

305                 310                 315                 320 





Asp Met Leu Glu Asn Gln Cys Asp Asn Lys Glu Asp Ile Leu Asn Lys 

                325                 330                 335     





Ala Leu Glu Leu Cys Glu Ile Leu Ala Lys Glu Lys Asp Thr Ile Arg 

            340                 345                 350         





Lys Glu Tyr Trp Arg Tyr Ile Gly Arg Ser Leu Gln Ser Lys His Ser 

        355                 360                 365             





Thr Glu Asn Asp Ser Pro Thr Asn Val Gln Gln 

    370                 375                 





<210>  7

<211>  2460

<212>  DNA

<213>  Homo sapiens



<400>  7

agctgcagcc acggccaata ggcgagagac ttcttgtttc ctggcagagc ggggtcccgg       60



caccgcggcg ctcgggtgtt tttgggggcc cgggtggagg gcccgggtgc cggggcccaa      120



ggtgcggcct cgctagcggg agagggagcg ggatcaccgg cccggagaga gctctcaggg      180



ccagagcggg gcaggaggat gctttcccag ccccaccatg gagctgcgct gtgggggatt      240



gctgttcagt tctcgctttg attcagggaa tctagcccac gtggagaagg tggaatcttt      300



gtccagtgat ggggaagggg taggaggtgg ggcgtcagcc ctgaccagtg gcattgcctc      360



ttcccctgac tatgaattca acgtgtggac ccgaccagac tgtgctgaaa cggaatttga      420



gaatgggaac aggtcatggt tctacttcag cgtccgggga ggaatgccag gaaaactcat      480



caagatcaac attatgaaca tgaacaagca gagcaagctg tattcccagg gcatggcccc      540



ctttgtgcgc acactgccca cccggccacg ctgggaacgc attcgagacc ggcccacctt      600



tgagatgaca gagacgcagt ttgtgttatc ctttgttcat cgtttcgtgg agggccgtgg      660



ggccaccacc ttcttcgcct tctgctaccc cttctcctac agtgactgcc aggaactgct      720



aaaccagcta gaccagcgct ttccggagaa ccaccctacc catagcagcc ccctggatac      780



catctattac catcgggagc tcctttgcta ttctctggat ggacttcgtg tagatctgct      840



gacgatcact tcctgccatg ggcttcgaga agatcgagag ccccgtctag agcagctatt      900



tcctgatacc agcacccctc gaccattccg tttcgcaggc aagaggatat tcttcttaag      960



cagtagagta cacccagggg agactccatc tagctttgtc ttcaatggct ttctggactt     1020



catcctccga cctgatgatc cccgggccca aaccctccgt cgcctcttcg tctttaagct     1080



gattcccatg ttgaaccccg atggtgtggt ccggggacac taccgcacag actcacgtgg     1140



agtgaatctg aaccgtcagt acctgaagcc tgatgccgtc ctgcacccgg ccatctatgg     1200



ggccaaagct gtgcttctct accaccatgt gcactctcgt ctgaactccc agagttcctc     1260



tgagcaccag cccagttcct gtctccctcc tgatgctcct gtttctgacc tggagaaagc     1320



caacaatctc caaaatgaag ctcagtgtgg gcactcagct gacaggcata acgctgaagc     1380



ctggaaacaa acagagccag cagaacagaa gctcaacagt gtgtggatta tgccacaaca     1440



gtctgcgggg cttgaagagt cagcccctga taccatcccc cccaaagaga gtggcgttgc     1500



ttactatgtg gacctgcatg gacatgcttc caaaaggggc tgcttcatgt acggaaacag     1560



ctttagtgat gagagcaccc aggtggaaaa catgctatat ccaaagctca tctccttgaa     1620



ttcagcccac ttcgacttcc agggctgcaa tttctcagag aagaatatgt atgcccgaga     1680



ccgtagagat ggccagtcta aagagggaag cggccgtgtt gcaatctaca aagcctcagg     1740



gataatccac agctacacac ttgaatgcaa ctacaacact ggacgctcag taaacagcat     1800



ccctgctgcc tgccatgaca atgggcgtgc cagcccccct cccccgccgg ctttcccctc     1860



cagatacact gtggaactat ttgagcaggt gggacgagct atggccattg cagccctgga     1920



catggcggaa tgtaatccgt ggccccgaat tgtactgtca gagcacagca gccttactaa     1980



tctacgggcc tggatgctga aacatgtacg caacagccga ggcctaagca gcactctgaa     2040



tgtgggtgtc aacaagaaga ggggccttcg aactccaccc aaaagtcaca atgggttgcc     2100



tgtctcctgc tccgaaaaca ccttgagtcg ggcacgaagt tttagcaccg gcacaagtgc     2160



cggtggtagc agcagcagcc aacaaaattc tccacagatg aagaattccc ccagctttcc     2220



ttttcatggc agtcggcctg cagggctgcc aggcctgggc tctagtaccc aaaaggtcac     2280



ccaccgggtg ctgggccccg tcagaggtaa gccagtctgg gagcccctgc aacatgtgtt     2340



cggttgtctg gggcattgct gggggaagta agagcttgaa gatatactgt tggcccagga     2400



ccaaggggtg aatcaataaa attagtttgt agcagaaaaa aaaaaaaaaa aaaaaaaaaa     2460





<210>  8

<211>  717

<212>  PRT

<213>  Homo sapiens



<400>  8



Met Glu Leu Arg Cys Gly Gly Leu Leu Phe Ser Ser Arg Phe Asp Ser 

1               5                   10                  15      





Gly Asn Leu Ala His Val Glu Lys Val Glu Ser Leu Ser Ser Asp Gly 

            20                  25                  30          





Glu Gly Val Gly Gly Gly Ala Ser Ala Leu Thr Ser Gly Ile Ala Ser 

        35                  40                  45              





Ser Pro Asp Tyr Glu Phe Asn Val Trp Thr Arg Pro Asp Cys Ala Glu 

    50                  55                  60                  





Thr Glu Phe Glu Asn Gly Asn Arg Ser Trp Phe Tyr Phe Ser Val Arg 

65                  70                  75                  80  





Gly Gly Met Pro Gly Lys Leu Ile Lys Ile Asn Ile Met Asn Met Asn 

                85                  90                  95      





Lys Gln Ser Lys Leu Tyr Ser Gln Gly Met Ala Pro Phe Val Arg Thr 

            100                 105                 110         





Leu Pro Thr Arg Pro Arg Trp Glu Arg Ile Arg Asp Arg Pro Thr Phe 

        115                 120                 125             





Glu Met Thr Glu Thr Gln Phe Val Leu Ser Phe Val His Arg Phe Val 

    130                 135                 140                 





Glu Gly Arg Gly Ala Thr Thr Phe Phe Ala Phe Cys Tyr Pro Phe Ser 

145                 150                 155                 160 





Tyr Ser Asp Cys Gln Glu Leu Leu Asn Gln Leu Asp Gln Arg Phe Pro 

                165                 170                 175     





Glu Asn His Pro Thr His Ser Ser Pro Leu Asp Thr Ile Tyr Tyr His 

            180                 185                 190         





Arg Glu Leu Leu Cys Tyr Ser Leu Asp Gly Leu Arg Val Asp Leu Leu 

        195                 200                 205             





Thr Ile Thr Ser Cys His Gly Leu Arg Glu Asp Arg Glu Pro Arg Leu 

    210                 215                 220                 





Glu Gln Leu Phe Pro Asp Thr Ser Thr Pro Arg Pro Phe Arg Phe Ala 

225                 230                 235                 240 





Gly Lys Arg Ile Phe Phe Leu Ser Ser Arg Val His Pro Gly Glu Thr 

                245                 250                 255     





Pro Ser Ser Phe Val Phe Asn Gly Phe Leu Asp Phe Ile Leu Arg Pro 

            260                 265                 270         





Asp Asp Pro Arg Ala Gln Thr Leu Arg Arg Leu Phe Val Phe Lys Leu 

        275                 280                 285             





Ile Pro Met Leu Asn Pro Asp Gly Val Val Arg Gly His Tyr Arg Thr 

    290                 295                 300                 





Asp Ser Arg Gly Val Asn Leu Asn Arg Gln Tyr Leu Lys Pro Asp Ala 

305                 310                 315                 320 





Val Leu His Pro Ala Ile Tyr Gly Ala Lys Ala Val Leu Leu Tyr His 

                325                 330                 335     





His Val His Ser Arg Leu Asn Ser Gln Ser Ser Ser Glu His Gln Pro 

            340                 345                 350         





Ser Ser Cys Leu Pro Pro Asp Ala Pro Val Ser Asp Leu Glu Lys Ala 

        355                 360                 365             





Asn Asn Leu Gln Asn Glu Ala Gln Cys Gly His Ser Ala Asp Arg His 

    370                 375                 380                 





Asn Ala Glu Ala Trp Lys Gln Thr Glu Pro Ala Glu Gln Lys Leu Asn 

385                 390                 395                 400 





Ser Val Trp Ile Met Pro Gln Gln Ser Ala Gly Leu Glu Glu Ser Ala 

                405                 410                 415     





Pro Asp Thr Ile Pro Pro Lys Glu Ser Gly Val Ala Tyr Tyr Val Asp 

            420                 425                 430         





Leu His Gly His Ala Ser Lys Arg Gly Cys Phe Met Tyr Gly Asn Ser 

        435                 440                 445             





Phe Ser Asp Glu Ser Thr Gln Val Glu Asn Met Leu Tyr Pro Lys Leu 

    450                 455                 460                 





Ile Ser Leu Asn Ser Ala His Phe Asp Phe Gln Gly Cys Asn Phe Ser 

465                 470                 475                 480 





Glu Lys Asn Met Tyr Ala Arg Asp Arg Arg Asp Gly Gln Ser Lys Glu 

                485                 490                 495     





Gly Ser Gly Arg Val Ala Ile Tyr Lys Ala Ser Gly Ile Ile His Ser 

            500                 505                 510         





Tyr Thr Leu Glu Cys Asn Tyr Asn Thr Gly Arg Ser Val Asn Ser Ile 

        515                 520                 525             





Pro Ala Ala Cys His Asp Asn Gly Arg Ala Ser Pro Pro Pro Pro Pro 

    530                 535                 540                 





Ala Phe Pro Ser Arg Tyr Thr Val Glu Leu Phe Glu Gln Val Gly Arg 

545                 550                 555                 560 





Ala Met Ala Ile Ala Ala Leu Asp Met Ala Glu Cys Asn Pro Trp Pro 

                565                 570                 575     





Arg Ile Val Leu Ser Glu His Ser Ser Leu Thr Asn Leu Arg Ala Trp 

            580                 585                 590         





Met Leu Lys His Val Arg Asn Ser Arg Gly Leu Ser Ser Thr Leu Asn 

        595                 600                 605             





Val Gly Val Asn Lys Lys Arg Gly Leu Arg Thr Pro Pro Lys Ser His 

    610                 615                 620                 





Asn Gly Leu Pro Val Ser Cys Ser Glu Asn Thr Leu Ser Arg Ala Arg 

625                 630                 635                 640 





Ser Phe Ser Thr Gly Thr Ser Ala Gly Gly Ser Ser Ser Ser Gln Gln 

                645                 650                 655     





Asn Ser Pro Gln Met Lys Asn Ser Pro Ser Phe Pro Phe His Gly Ser 

            660                 665                 670         





Arg Pro Ala Gly Leu Pro Gly Leu Gly Ser Ser Thr Gln Lys Val Thr 

        675                 680                 685             





His Arg Val Leu Gly Pro Val Arg Gly Lys Pro Val Trp Glu Pro Leu 

    690                 695                 700                 





Gln His Val Phe Gly Cys Leu Gly His Cys Trp Gly Lys 

705                 710                 715         





<210>  9

<211>  3254

<212>  DNA

<213>  Homo sapiens



<400>  9

agctgcagcc acggccaata ggcgagagac ttcttgtttc ctggcagagc ggggtcccgg       60



caccgcggcg ctcgggtgtt tttgggggcc cgggtggagg gcccgggtgc cggggcccaa      120



ggtgcggcct cgctagcggg agagggagcg ggatcaccgg cccggagaga gctctcaggg      180



ccagagcggg gcaggaggat gctttcccag ccccaccatg gagctgcgct gtgggggatt      240



gctgttcagt tctcgctttg attcagggaa tctagcccac gtggagaagg tggaatcttt      300



gtccagtgat ggggaagggg taggaggtgg ggcgtcagcc ctgaccagtg gcattgcctc      360



ttcccctgac tatgaattca acgtgtggac ccgaccagac tgtgctgaaa cggaatttga      420



gaatgggaac aggtcatggt tctacttcag cgtccgggga ggaatgccag gaaaactcat      480



caagatcaac attatgaaca tgaacaagca gagcaagctg tattcccagg gcatggcccc      540



ctttgtgcgc acactgccca cccggccacg ctgggaacgc attcgagacc ggcccacctt      600



tgagatgaca gagacgcagt ttgtgttatc ctttgttcat cgtttcgtgg agggccgtgg      660



ggccaccacc ttcttcgcct tctgctaccc cttctcctac agtgactgcc aggaactgct      720



aaaccagcta gaccagcgct ttccggagaa ccaccctacc catagcagcc ccctggatac      780



catctattac catcgggagc tcctttgcta ttctctggat ggacttcgtg tagatctgct      840



gacgatcact tcctgccatg ggcttcgaga agatcgagag ccccgtctag agcagctatt      900



tcctgatacc agcacccctc gaccattccg tttcgcaggc aagaggatat tcttcttaag      960



cagtagagta cacccagggg agactccatc tagctttgtc ttcaatggct ttctggactt     1020



catcctccga cctgatgatc cccgggccca aaccctccgt cgcctcttcg tctttaagct     1080



gattcccatg ttgaaccccg atggtgtggt ccggggacac taccgcacag actcacgtgg     1140



agtgaatctg aaccgtcagt acctgaagcc tgatgccgtc ctgcacccgg ccatctatgg     1200



ggccaaagct gtgcttctct accaccatgt gcactctcgt ctgaactccc agagttcctc     1260



tgagcaccag cccagttcct gtctccctcc tgatgctcct gtttctgacc tggagaaagc     1320



caacaatctc caaaatgaag ctcagtgtgg gcactcagct gacaggcata acgctgaagc     1380



ctggaaacaa acagagccag cagaacagaa gctcaacagt gtgtggatta tgccacaaca     1440



gtctgcgggg cttgaagagt cagcccctga taccatcccc cccaaagaga gtggcgttgc     1500



ttactatgtg gacctgcatg gacatgcttc caaaaggggc tgcttcatgt acggaaacag     1560



ctttagtgat gagagcaccc aggtggaaaa catgctatat ccaaagctca tctccttgaa     1620



ttcagcccac ttcgacttcc agggctgcaa tttctcagag aagaatatgt atgcccgaga     1680



ccgtagagat ggccagtcta aagagggaag cggccgtgtt gcaatctaca aagcctcagg     1740



gataatccac agctacacac ttgaatgcaa ctacaacact ggacgctcag taaacagcat     1800



ccctgctgcc tgccatgaca atgggcgtgc cagcccccct cccccgccgg ctttcccctc     1860



cagatacact gtggaactat ttgagcaggt gggacgagct atggccattg cagccctgga     1920



catggcggaa tgtaatccgt ggccccgaat tgtactgtca gagcacagca gccttactaa     1980



tctacgggcc tggatgctga aacatgtacg caacagccga ggcctaagca gcactctgaa     2040



tgtgggtgtc aacaagaaga ggggccttcg aactccaccc aaaagtcaca atgggttgcc     2100



tgtctcctgc tccgaaaaca ccttgagtcg ggcacgaagt tttagcaccg gcacaagtgc     2160



cggtggtagc agcagcagcc aacaaaattc tccacagatg aagaattccc ccagctttcc     2220



ttttcatggc agtcggcctg cagggctgcc aggcctgggc tctagtaccc aaaaggtcac     2280



ccaccgggtg ctgggccccg tcagagagcc ccgaagccag gacaggagac ggcagcagca     2340



gcccctgaac catcgtcctg caggcagcct cgctccatcc ccagctccta ctagttctgg     2400



cccagcctcc tcacacaagc tgggctcctg tctactgcct gattcattca acataccagg     2460



gagcagttgc tcactcttgt cctctggaga caaaccagag gctgtcatgg taatcgggaa     2520



aggtctgcta gggactggag ctcggatgcc ctgcatcaag actcgattgc aggctaggcc     2580



caggttgggc cggggctcac cgccgactcg cagagggatg aaaggctctt caggccccac     2640



atcccctacc ccccggacca gggagagcag tgagctggag ctgggatcct gctctgctac     2700



accagggctg cctcaggcca ggcccccacg gccccgctct gcccctgcct tttctcctat     2760



atcctgtagt ctatctgact ccccatcctg gaattgttac agcaggggtc ccttgggcca     2820



acctgaggtt tgttttgtcc ctaaatctcc cccactgact gtttctcccc gggtctgata     2880



atgcctttat gttcaagccc aggatatagc cccaagatgg ggtaacagtg ggaaatatgc     2940



tagttcccct ccaggccgct gattccatgt gacagccgtt aagtccttgg aatgccagcc     3000



acgctgtcca aggcattaca gagtatcacc ttgagacaga acaaaacagg gacctgccac     3060



cccttccctc cctccgcagc acaagatttt gggaccacaa aaaaaagtct atatttttat     3120



attgggggga gggagtagaa aagcaagccc ctatactggg ccctattcag tggcagcttc     3180



ttgttccata ggattaagga agactctgag gaaataaaag ttgtttggaa aaatccaaaa     3240



aaaaaaaaaa aaaa                                                       3254





<210>  10

<211>  886

<212>  PRT

<213>  Homo sapiens



<400>  10



Met Glu Leu Arg Cys Gly Gly Leu Leu Phe Ser Ser Arg Phe Asp Ser 

1               5                   10                  15      





Gly Asn Leu Ala His Val Glu Lys Val Glu Ser Leu Ser Ser Asp Gly 

            20                  25                  30          





Glu Gly Val Gly Gly Gly Ala Ser Ala Leu Thr Ser Gly Ile Ala Ser 

        35                  40                  45              





Ser Pro Asp Tyr Glu Phe Asn Val Trp Thr Arg Pro Asp Cys Ala Glu 

    50                  55                  60                  





Thr Glu Phe Glu Asn Gly Asn Arg Ser Trp Phe Tyr Phe Ser Val Arg 

65                  70                  75                  80  





Gly Gly Met Pro Gly Lys Leu Ile Lys Ile Asn Ile Met Asn Met Asn 

                85                  90                  95      





Lys Gln Ser Lys Leu Tyr Ser Gln Gly Met Ala Pro Phe Val Arg Thr 

            100                 105                 110         





Leu Pro Thr Arg Pro Arg Trp Glu Arg Ile Arg Asp Arg Pro Thr Phe 

        115                 120                 125             





Glu Met Thr Glu Thr Gln Phe Val Leu Ser Phe Val His Arg Phe Val 

    130                 135                 140                 





Glu Gly Arg Gly Ala Thr Thr Phe Phe Ala Phe Cys Tyr Pro Phe Ser 

145                 150                 155                 160 





Tyr Ser Asp Cys Gln Glu Leu Leu Asn Gln Leu Asp Gln Arg Phe Pro 

                165                 170                 175     





Glu Asn His Pro Thr His Ser Ser Pro Leu Asp Thr Ile Tyr Tyr His 

            180                 185                 190         





Arg Glu Leu Leu Cys Tyr Ser Leu Asp Gly Leu Arg Val Asp Leu Leu 

        195                 200                 205             





Thr Ile Thr Ser Cys His Gly Leu Arg Glu Asp Arg Glu Pro Arg Leu 

    210                 215                 220                 





Glu Gln Leu Phe Pro Asp Thr Ser Thr Pro Arg Pro Phe Arg Phe Ala 

225                 230                 235                 240 





Gly Lys Arg Ile Phe Phe Leu Ser Ser Arg Val His Pro Gly Glu Thr 

                245                 250                 255     





Pro Ser Ser Phe Val Phe Asn Gly Phe Leu Asp Phe Ile Leu Arg Pro 

            260                 265                 270         





Asp Asp Pro Arg Ala Gln Thr Leu Arg Arg Leu Phe Val Phe Lys Leu 

        275                 280                 285             





Ile Pro Met Leu Asn Pro Asp Gly Val Val Arg Gly His Tyr Arg Thr 

    290                 295                 300                 





Asp Ser Arg Gly Val Asn Leu Asn Arg Gln Tyr Leu Lys Pro Asp Ala 

305                 310                 315                 320 





Val Leu His Pro Ala Ile Tyr Gly Ala Lys Ala Val Leu Leu Tyr His 

                325                 330                 335     





His Val His Ser Arg Leu Asn Ser Gln Ser Ser Ser Glu His Gln Pro 

            340                 345                 350         





Ser Ser Cys Leu Pro Pro Asp Ala Pro Val Ser Asp Leu Glu Lys Ala 

        355                 360                 365             





Asn Asn Leu Gln Asn Glu Ala Gln Cys Gly His Ser Ala Asp Arg His 

    370                 375                 380                 





Asn Ala Glu Ala Trp Lys Gln Thr Glu Pro Ala Glu Gln Lys Leu Asn 

385                 390                 395                 400 





Ser Val Trp Ile Met Pro Gln Gln Ser Ala Gly Leu Glu Glu Ser Ala 

                405                 410                 415     





Pro Asp Thr Ile Pro Pro Lys Glu Ser Gly Val Ala Tyr Tyr Val Asp 

            420                 425                 430         





Leu His Gly His Ala Ser Lys Arg Gly Cys Phe Met Tyr Gly Asn Ser 

        435                 440                 445             





Phe Ser Asp Glu Ser Thr Gln Val Glu Asn Met Leu Tyr Pro Lys Leu 

    450                 455                 460                 





Ile Ser Leu Asn Ser Ala His Phe Asp Phe Gln Gly Cys Asn Phe Ser 

465                 470                 475                 480 





Glu Lys Asn Met Tyr Ala Arg Asp Arg Arg Asp Gly Gln Ser Lys Glu 

                485                 490                 495     





Gly Ser Gly Arg Val Ala Ile Tyr Lys Ala Ser Gly Ile Ile His Ser 

            500                 505                 510         





Tyr Thr Leu Glu Cys Asn Tyr Asn Thr Gly Arg Ser Val Asn Ser Ile 

        515                 520                 525             





Pro Ala Ala Cys His Asp Asn Gly Arg Ala Ser Pro Pro Pro Pro Pro 

    530                 535                 540                 





Ala Phe Pro Ser Arg Tyr Thr Val Glu Leu Phe Glu Gln Val Gly Arg 

545                 550                 555                 560 





Ala Met Ala Ile Ala Ala Leu Asp Met Ala Glu Cys Asn Pro Trp Pro 

                565                 570                 575     





Arg Ile Val Leu Ser Glu His Ser Ser Leu Thr Asn Leu Arg Ala Trp 

            580                 585                 590         





Met Leu Lys His Val Arg Asn Ser Arg Gly Leu Ser Ser Thr Leu Asn 

        595                 600                 605             





Val Gly Val Asn Lys Lys Arg Gly Leu Arg Thr Pro Pro Lys Ser His 

    610                 615                 620                 





Asn Gly Leu Pro Val Ser Cys Ser Glu Asn Thr Leu Ser Arg Ala Arg 

625                 630                 635                 640 





Ser Phe Ser Thr Gly Thr Ser Ala Gly Gly Ser Ser Ser Ser Gln Gln 

                645                 650                 655     





Asn Ser Pro Gln Met Lys Asn Ser Pro Ser Phe Pro Phe His Gly Ser 

            660                 665                 670         





Arg Pro Ala Gly Leu Pro Gly Leu Gly Ser Ser Thr Gln Lys Val Thr 

        675                 680                 685             





His Arg Val Leu Gly Pro Val Arg Glu Pro Arg Ser Gln Asp Arg Arg 

    690                 695                 700                 





Arg Gln Gln Gln Pro Leu Asn His Arg Pro Ala Gly Ser Leu Ala Pro 

705                 710                 715                 720 





Ser Pro Ala Pro Thr Ser Ser Gly Pro Ala Ser Ser His Lys Leu Gly 

                725                 730                 735     





Ser Cys Leu Leu Pro Asp Ser Phe Asn Ile Pro Gly Ser Ser Cys Ser 

            740                 745                 750         





Leu Leu Ser Ser Gly Asp Lys Pro Glu Ala Val Met Val Ile Gly Lys 

        755                 760                 765             





Gly Leu Leu Gly Thr Gly Ala Arg Met Pro Cys Ile Lys Thr Arg Leu 

    770                 775                 780                 





Gln Ala Arg Pro Arg Leu Gly Arg Gly Ser Pro Pro Thr Arg Arg Gly 

785                 790                 795                 800 





Met Lys Gly Ser Ser Gly Pro Thr Ser Pro Thr Pro Arg Thr Arg Glu 

                805                 810                 815     





Ser Ser Glu Leu Glu Leu Gly Ser Cys Ser Ala Thr Pro Gly Leu Pro 

            820                 825                 830         





Gln Ala Arg Pro Pro Arg Pro Arg Ser Ala Pro Ala Phe Ser Pro Ile 

        835                 840                 845             





Ser Cys Ser Leu Ser Asp Ser Pro Ser Trp Asn Cys Tyr Ser Arg Gly 

    850                 855                 860                 





Pro Leu Gly Gln Pro Glu Val Cys Phe Val Pro Lys Ser Pro Pro Leu 

865                 870                 875                 880 





Thr Val Ser Pro Arg Val 

                885     





<210>  11

<211>  2794

<212>  DNA

<213>  Homo sapiens



<400>  11

cggcaggacc gagcgcggca ggcggctggc ccagcgcagc cagcgcggcc cgaaggacgg       60



gagcaggcgg ccgagcaccg agcgctgggc accgggcacc gagcggcggc ggcacgcgag      120



gcccggcccc gagcagcgcc cccgcccgcc gcggcctcca gcccggcccc gcccagcgcc      180



ggcccgcggg gatgcggagc ggcgggcgcc ggaggccgcg gcccggctag gcccgcgctc      240



gcgcccggac gcggcggccc gaggctgtgg ccaggccagc tgggctcggg gagcgccagc      300



ctgagaggag cgcgtgagcg tcgcgggagc ctcgggcacc atgagcgacg tggctattgt      360



gaaggagggt tggctgcaca aacgagggga gtacatcaag acctggcggc cacgctactt      420



cctcctcaag aatgatggca ccttcattgg ctacaaggag cggccgcagg atgtggacca      480



acgtgaggct cccctcaaca acttctctgt ggcgcagtgc cagctgatga agacggagcg      540



gccccggccc aacaccttca tcatccgctg cctgcagtgg accactgtca tcgaacgcac      600



cttccatgtg gagactcctg aggagcggga ggagtggaca accgccatcc agactgtggc      660



tgacggcctc aagaagcagg aggaggagga gatggacttc cggtcgggct cacccagtga      720



caactcaggg gctgaagaga tggaggtgtc cctggccaag cccaagcacc gcgtgaccat      780



gaacgagttt gagtacctga agctgctggg caagggcact ttcggcaagg tgatcctggt      840



gaaggagaag gccacaggcc gctactacgc catgaagatc ctcaagaagg aagtcatcgt      900



ggccaaggac gaggtggccc acacactcac cgagaaccgc gtcctgcaga actccaggca      960



ccccttcctc acagccctga agtactcttt ccagacccac gaccgcctct gctttgtcat     1020



ggagtacgcc aacgggggcg agctgttctt ccacctgtcc cgggagcgtg tgttctccga     1080



ggaccgggcc cgcttctatg gcgctgagat tgtgtcagcc ctggactacc tgcactcgga     1140



gaagaacgtg gtgtaccggg acctcaagct ggagaacctc atgctggaca aggacgggca     1200



cattaagatc acagacttcg ggctgtgcaa ggaggggatc aaggacggtg ccaccatgaa     1260



gaccttttgc ggcacacctg agtacctggc ccccgaggtg ctggaggaca atgactacgg     1320



ccgtgcagtg gactggtggg ggctgggcgt ggtcatgtac gagatgatgt gcggtcgcct     1380



gcccttctac aaccaggacc atgagaagct ttttgagctc atcctcatgg aggagatccg     1440



cttcccgcgc acgcttggtc ccgaggccaa gtccttgctt tcagggctgc tcaagaagga     1500



ccccaagcag aggcttggcg ggggctccga ggacgccaag gagatcatgc agcatcgctt     1560



ctttgccggt atcgtgtggc agcacgtgta cgagaagaag ctcagcccac ccttcaagcc     1620



ccaggtcacg tcggagactg acaccaggta ttttgatgag gagttcacgg cccagatgat     1680



caccatcaca ccacctgacc aagatgacag catggagtgt gtggacagcg agcgcaggcc     1740



ccacttcccc cagttctcct actcggccag cggcacggcc tgaggcggcg gtggactgcg     1800



ctggacgata gcttggaggg atggagaggc ggcctcgtgc catgatctgt atttaatggt     1860



ttttatttct cgggtgcatt tgagagaagc cacgctgtcc tctcgagccc agatggaaag     1920



acgtttttgt gctgtgggca gcaccctccc ccgcagcggg gtagggaaga aaactatcct     1980



gcgggtttta atttatttca tccagtttgt tctccgggtg tggcctcagc cctcagaaca     2040



atccgattca cgtagggaaa tgttaaggac ttctgcagct atgcgcaatg tggcattggg     2100



gggccgggca ggtcctgccc atgtgtcccc tcactctgtc agccagccgc cctgggctgt     2160



ctgtcaccag ctatctgtca tctctctggg gccctgggcc tcagttcaac ctggtggcac     2220



cagatgcaac ctcactatgg tatgctggcc agcaccctct cctgggggtg gcaggcacac     2280



agcagccccc cagcactaag gccgtgtctc tgaggacgtc atcggaggct gggcccctgg     2340



gatgggacca gggatggggg atgggccagg gtttacccag tgggacagag gagcaaggtt     2400



taaatttgtt attgtgtatt atgttgttca aatgcatttt gggggttttt aatctttgtg     2460



acaggaaagc cctccccctt ccccttctgt gtcacagttc ttggtgactg tcccaccggg     2520



agcctccccc tcagatgatc tctccacggt agcacttgac cttttcgacg cttaaccttt     2580



ccgctgtcgc cccaggccct ccctgactcc ctgtgggggt ggccatccct gggcccctcc     2640



acgcctcctg gccagacgct gccgctgccg ctgcaccacg gcgttttttt acaacattca     2700



actttagtat ttttactatt ataatataat atggaacctt ccctccaaat tcttcaataa     2760



aagttgcttt tcaaaaaaaa aaaaaaaaaa aaaa                                 2794





<210>  12

<211>  480

<212>  PRT

<213>  Homo sapiens



<400>  12



Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 

1               5                   10                  15      





Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 

            20                  25                  30          





Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 

        35                  40                  45              





Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 

    50                  55                  60                  





Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 

65                  70                  75                  80  





Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 

                85                  90                  95      





Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 

            100                 105                 110         





Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 

        115                 120                 125             





Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 

    130                 135                 140                 





Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 

145                 150                 155                 160 





Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 

                165                 170                 175     





Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 

            180                 185                 190         





Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 

        195                 200                 205             





Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 

    210                 215                 220                 





Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 

225                 230                 235                 240 





Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 

                245                 250                 255     





Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 

            260                 265                 270         





Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 

        275                 280                 285             





Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 

    290                 295                 300                 





Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 

305                 310                 315                 320 





Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 

                325                 330                 335     





Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 

            340                 345                 350         





Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 

        355                 360                 365             





Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 

    370                 375                 380                 





Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 

385                 390                 395                 400 





Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 

                405                 410                 415     





Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 

            420                 425                 430         





Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 

        435                 440                 445             





Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 

    450                 455                 460                 





Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 

465                 470                 475                 480 





<210>  13

<211>  2878

<212>  DNA

<213>  Homo sapiens



<400>  13

cggcaggacc gagcgcggca ggcggctggc ccagcgcagc cagcgcggcc cgaaggacgg       60



gagcaggcgg ccgagcaccg agcgctgggc accgggcacc gagcggcggc ggcacgcgag      120



gcccggcccc gagcagcgcc cccgcccgcc gcggcctcca gcccggcccc gcccagcgcc      180



ggcccgcggg gatgcggagc ggcgggcgcc ggaggccgcg gcccggctag gcccgcgctc      240



gcgcccggac gcggcggccc ggggcttagg gaaggccgag ccagcctggg tcaaagaagt      300



caaaggggct gcctggagga ggcagcctgt cagctggtgc atcagaggct gtggccaggc      360



cagctgggct cggggagcgc cagcctgaga ggagcgcgtg agcgtcgcgg gagcctcggg      420



caccatgagc gacgtggcta ttgtgaagga gggttggctg cacaaacgag gggagtacat      480



caagacctgg cggccacgct acttcctcct caagaatgat ggcaccttca ttggctacaa      540



ggagcggccg caggatgtgg accaacgtga ggctcccctc aacaacttct ctgtggcgca      600



gtgccagctg atgaagacgg agcggccccg gcccaacacc ttcatcatcc gctgcctgca      660



gtggaccact gtcatcgaac gcaccttcca tgtggagact cctgaggagc gggaggagtg      720



gacaaccgcc atccagactg tggctgacgg cctcaagaag caggaggagg aggagatgga      780



cttccggtcg ggctcaccca gtgacaactc aggggctgaa gagatggagg tgtccctggc      840



caagcccaag caccgcgtga ccatgaacga gtttgagtac ctgaagctgc tgggcaaggg      900



cactttcggc aaggtgatcc tggtgaagga gaaggccaca ggccgctact acgccatgaa      960



gatcctcaag aaggaagtca tcgtggccaa ggacgaggtg gcccacacac tcaccgagaa     1020



ccgcgtcctg cagaactcca ggcacccctt cctcacagcc ctgaagtact ctttccagac     1080



ccacgaccgc ctctgctttg tcatggagta cgccaacggg ggcgagctgt tcttccacct     1140



gtcccgggag cgtgtgttct ccgaggaccg ggcccgcttc tatggcgctg agattgtgtc     1200



agccctggac tacctgcact cggagaagaa cgtggtgtac cgggacctca agctggagaa     1260



cctcatgctg gacaaggacg ggcacattaa gatcacagac ttcgggctgt gcaaggaggg     1320



gatcaaggac ggtgccacca tgaagacctt ttgcggcaca cctgagtacc tggcccccga     1380



ggtgctggag gacaatgact acggccgtgc agtggactgg tgggggctgg gcgtggtcat     1440



gtacgagatg atgtgcggtc gcctgccctt ctacaaccag gaccatgaga agctttttga     1500



gctcatcctc atggaggaga tccgcttccc gcgcacgctt ggtcccgagg ccaagtcctt     1560



gctttcaggg ctgctcaaga aggaccccaa gcagaggctt ggcgggggct ccgaggacgc     1620



caaggagatc atgcagcatc gcttctttgc cggtatcgtg tggcagcacg tgtacgagaa     1680



gaagctcagc ccacccttca agccccaggt cacgtcggag actgacacca ggtattttga     1740



tgaggagttc acggcccaga tgatcaccat cacaccacct gaccaagatg acagcatgga     1800



gtgtgtggac agcgagcgca ggccccactt cccccagttc tcctactcgg ccagcggcac     1860



ggcctgaggc ggcggtggac tgcgctggac gatagcttgg agggatggag aggcggcctc     1920



gtgccatgat ctgtatttaa tggtttttat ttctcgggtg catttgagag aagccacgct     1980



gtcctctcga gcccagatgg aaagacgttt ttgtgctgtg ggcagcaccc tcccccgcag     2040



cggggtaggg aagaaaacta tcctgcgggt tttaatttat ttcatccagt ttgttctccg     2100



ggtgtggcct cagccctcag aacaatccga ttcacgtagg gaaatgttaa ggacttctgc     2160



agctatgcgc aatgtggcat tggggggccg ggcaggtcct gcccatgtgt cccctcactc     2220



tgtcagccag ccgccctggg ctgtctgtca ccagctatct gtcatctctc tggggccctg     2280



ggcctcagtt caacctggtg gcaccagatg caacctcact atggtatgct ggccagcacc     2340



ctctcctggg ggtggcaggc acacagcagc cccccagcac taaggccgtg tctctgagga     2400



cgtcatcgga ggctgggccc ctgggatggg accagggatg ggggatgggc cagggtttac     2460



ccagtgggac agaggagcaa ggtttaaatt tgttattgtg tattatgttg ttcaaatgca     2520



ttttgggggt ttttaatctt tgtgacagga aagccctccc ccttcccctt ctgtgtcaca     2580



gttcttggtg actgtcccac cgggagcctc cccctcagat gatctctcca cggtagcact     2640



tgaccttttc gacgcttaac ctttccgctg tcgccccagg ccctccctga ctccctgtgg     2700



gggtggccat ccctgggccc ctccacgcct cctggccaga cgctgccgct gccgctgcac     2760



cacggcgttt ttttacaaca ttcaacttta gtatttttac tattataata taatatggaa     2820



ccttccctcc aaattcttca ataaaagttg cttttcaaaa aaaaaaaaaa aaaaaaaa       2878





<210>  14

<211>  480

<212>  PRT

<213>  Homo sapiens



<400>  14



Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 

1               5                   10                  15      





Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 

            20                  25                  30          





Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 

        35                  40                  45              





Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 

    50                  55                  60                  





Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 

65                  70                  75                  80  





Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 

                85                  90                  95      





Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 

            100                 105                 110         





Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 

        115                 120                 125             





Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 

    130                 135                 140                 





Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 

145                 150                 155                 160 





Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 

                165                 170                 175     





Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 

            180                 185                 190         





Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 

        195                 200                 205             





Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 

    210                 215                 220                 





Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 

225                 230                 235                 240 





Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 

                245                 250                 255     





Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 

            260                 265                 270         





Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 

        275                 280                 285             





Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 

    290                 295                 300                 





Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 

305                 310                 315                 320 





Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 

                325                 330                 335     





Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 

            340                 345                 350         





Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 

        355                 360                 365             





Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 

    370                 375                 380                 





Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 

385                 390                 395                 400 





Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 

                405                 410                 415     





Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 

            420                 425                 430         





Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 

        435                 440                 445             





Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 

    450                 455                 460                 





Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 

465                 470                 475                 480 





<210>  15

<211>  3008

<212>  DNA

<213>  Homo sapiens



<400>  15

taattatggg tctgtaacca ccctggactg ggtgctcctc actgacggac ttgtctgaac       60



ctctctttgt ctccagcgcc cagcactggg cctggcaaaa cctgagacgc ccggtacatg      120



ttggccaaat gaatgaacca gattcagacc ggcaggggcg ctgtggttta ggaggggcct      180



ggggtttctc ccaggaggtt tttgggcttg cgctggaggg ctctggactc ccgtttgcgc      240



cagtggcctg catcctggtc ctgtcttcct catgtttgaa tttctttgct ttcctagtct      300



ggggagcagg gaggagccct gtgccctgtc ccaggatcca tgggtaggaa caccatggac      360



agggagagca aacggggcca tctgtcacca ggggcttagg gaaggccgag ccagcctggg      420



tcaaagaagt caaaggggct gcctggagga ggcagcctgt cagctggtgc atcagaggct      480



gtggccaggc cagctgggct cggggagcgc cagcctgaga ggagcgcgtg agcgtcgcgg      540



gagcctcggg caccatgagc gacgtggcta ttgtgaagga gggttggctg cacaaacgag      600



gggagtacat caagacctgg cggccacgct acttcctcct caagaatgat ggcaccttca      660



ttggctacaa ggagcggccg caggatgtgg accaacgtga ggctcccctc aacaacttct      720



ctgtggcgca gtgccagctg atgaagacgg agcggccccg gcccaacacc ttcatcatcc      780



gctgcctgca gtggaccact gtcatcgaac gcaccttcca tgtggagact cctgaggagc      840



gggaggagtg gacaaccgcc atccagactg tggctgacgg cctcaagaag caggaggagg      900



aggagatgga cttccggtcg ggctcaccca gtgacaactc aggggctgaa gagatggagg      960



tgtccctggc caagcccaag caccgcgtga ccatgaacga gtttgagtac ctgaagctgc     1020



tgggcaaggg cactttcggc aaggtgatcc tggtgaagga gaaggccaca ggccgctact     1080



acgccatgaa gatcctcaag aaggaagtca tcgtggccaa ggacgaggtg gcccacacac     1140



tcaccgagaa ccgcgtcctg cagaactcca ggcacccctt cctcacagcc ctgaagtact     1200



ctttccagac ccacgaccgc ctctgctttg tcatggagta cgccaacggg ggcgagctgt     1260



tcttccacct gtcccgggag cgtgtgttct ccgaggaccg ggcccgcttc tatggcgctg     1320



agattgtgtc agccctggac tacctgcact cggagaagaa cgtggtgtac cgggacctca     1380



agctggagaa cctcatgctg gacaaggacg ggcacattaa gatcacagac ttcgggctgt     1440



gcaaggaggg gatcaaggac ggtgccacca tgaagacctt ttgcggcaca cctgagtacc     1500



tggcccccga ggtgctggag gacaatgact acggccgtgc agtggactgg tgggggctgg     1560



gcgtggtcat gtacgagatg atgtgcggtc gcctgccctt ctacaaccag gaccatgaga     1620



agctttttga gctcatcctc atggaggaga tccgcttccc gcgcacgctt ggtcccgagg     1680



ccaagtcctt gctttcaggg ctgctcaaga aggaccccaa gcagaggctt ggcgggggct     1740



ccgaggacgc caaggagatc atgcagcatc gcttctttgc cggtatcgtg tggcagcacg     1800



tgtacgagaa gaagctcagc ccacccttca agccccaggt cacgtcggag actgacacca     1860



ggtattttga tgaggagttc acggcccaga tgatcaccat cacaccacct gaccaagatg     1920



acagcatgga gtgtgtggac agcgagcgca ggccccactt cccccagttc tcctactcgg     1980



ccagcggcac ggcctgaggc ggcggtggac tgcgctggac gatagcttgg agggatggag     2040



aggcggcctc gtgccatgat ctgtatttaa tggtttttat ttctcgggtg catttgagag     2100



aagccacgct gtcctctcga gcccagatgg aaagacgttt ttgtgctgtg ggcagcaccc     2160



tcccccgcag cggggtaggg aagaaaacta tcctgcgggt tttaatttat ttcatccagt     2220



ttgttctccg ggtgtggcct cagccctcag aacaatccga ttcacgtagg gaaatgttaa     2280



ggacttctgc agctatgcgc aatgtggcat tggggggccg ggcaggtcct gcccatgtgt     2340



cccctcactc tgtcagccag ccgccctggg ctgtctgtca ccagctatct gtcatctctc     2400



tggggccctg ggcctcagtt caacctggtg gcaccagatg caacctcact atggtatgct     2460



ggccagcacc ctctcctggg ggtggcaggc acacagcagc cccccagcac taaggccgtg     2520



tctctgagga cgtcatcgga ggctgggccc ctgggatggg accagggatg ggggatgggc     2580



cagggtttac ccagtgggac agaggagcaa ggtttaaatt tgttattgtg tattatgttg     2640



ttcaaatgca ttttgggggt ttttaatctt tgtgacagga aagccctccc ccttcccctt     2700



ctgtgtcaca gttcttggtg actgtcccac cgggagcctc cccctcagat gatctctcca     2760



cggtagcact tgaccttttc gacgcttaac ctttccgctg tcgccccagg ccctccctga     2820



ctccctgtgg gggtggccat ccctgggccc ctccacgcct cctggccaga cgctgccgct     2880



gccgctgcac cacggcgttt ttttacaaca ttcaacttta gtatttttac tattataata     2940



taatatggaa ccttccctcc aaattcttca ataaaagttg cttttcaaaa aaaaaaaaaa     3000



aaaaaaaa                                                              3008





<210>  16

<211>  480

<212>  PRT

<213>  Homo sapiens



<400>  16



Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 

1               5                   10                  15      





Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 

            20                  25                  30          





Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 

        35                  40                  45              





Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 

    50                  55                  60                  





Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 

65                  70                  75                  80  





Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 

                85                  90                  95      





Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 

            100                 105                 110         





Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 

        115                 120                 125             





Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 

    130                 135                 140                 





Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 

145                 150                 155                 160 





Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 

                165                 170                 175     





Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 

            180                 185                 190         





Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 

        195                 200                 205             





Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 

    210                 215                 220                 





Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 

225                 230                 235                 240 





Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 

                245                 250                 255     





Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 

            260                 265                 270         





Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 

        275                 280                 285             





Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 

    290                 295                 300                 





Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 

305                 310                 315                 320 





Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 

                325                 330                 335     





Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 

            340                 345                 350         





Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 

        355                 360                 365             





Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 

    370                 375                 380                 





Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 

385                 390                 395                 400 





Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 

                405                 410                 415     





Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 

            420                 425                 430         





Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 

        435                 440                 445             





Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 

    450                 455                 460                 





Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 

465                 470                 475                 480 





<210>  17

<211>  4405

<212>  DNA

<213>  Homo sapiens



<400>  17

ctagtctata ccagcaacga ctcctacatc gtccactctg gggatcttag aaagatccat       60



aaagctgcct cccggggaca agtccggaag ctggagaaga tgacaaagag gaagaagacc      120



atcaacctta atatacaaga cgcccagaag aggactgctc tacactgggc ctgtgtcaat      180



ggccatgagg aagtagtaac atttctggta gacagaaagt gccagcttga cgtccttgat      240



ggcgaacaca ggacacctct gatgaaggct ctacaatgcc atcaggaggc ttgtgcaaat      300



attctgatag attctggtgc cgatataaat ctcgtagatg tgtatggcaa cacggctctc      360



cattatgctg tttatagtga gattttgtca gtggtggcaa aactgctgtc ccatggtgca      420



gtcatcgaag tgcacaacaa ggctagcctc acaccacttt tactatccat aacgaaaaga      480



agtgagcaaa ttgtggaatt tttgctgata aaaaatgcaa atgcgaatgc agttaataag      540



tataaatgca cagccctcat gcttgctgta tgtcatggat catcagagat agttggcatg      600



cttcttcagc aaaatgttga cgtctttgct gcagatatat gtggagtaac tgcagaacat      660



tatgctgtta cttgtggatt tcatcacatt catgaacaaa ttatggaata tatacgaaaa      720



ttatctaaaa atcatcaaaa taccaatcca gaaggaacat ctgcaggaac acctgatgag      780



gctgcaccct tggcggaaag aacacctgac acagctgaaa gcttggtgga aaaaacacct      840



gatgaggctg cacccttggt ggaaagaaca cctgacacgg ctgaaagctt ggtggaaaaa      900



acacctgatg aggctgcatc cttggtggag ggaacatctg acaaaattca atgtttggag      960



aaagcgacat ctggaaagtt cgaacagtca gcagaagaaa cacctaggga aattacgagt     1020



cctgcaaaag aaacatctga gaaatttacg tggccagcaa aaggaagacc taggaagatc     1080



gcatgggaga aaaaagaaga cacacctagg gaaattatga gtcccgcaaa agaaacatct     1140



gagaaattta cgtgggcagc aaaaggaaga cctaggaaga tcgcatggga gaaaaaagaa     1200



acacctgtaa agactggatg cgtggcaaga gtaacatcta ataaaactaa agttttggaa     1260



aaaggaagat ctaagatgat tgcatgtcct acaaaagaat catctacaaa agcaagtgcc     1320



aatgatcaga ggttcccatc agaatccaaa caagaggaag atgaagaata ttcttgtgat     1380



tctcggagtc tctttgagag ttctgcaaag attcaagtgt gtatacctga gtctatatat     1440



caaaaagtaa tggagataaa tagagaagta gaagagcctc ctaagaagcc atctgccttc     1500



aagcctgcca ttgaaatgca aaactctgtt ccaaataaag cctttgaatt gaagaatgaa     1560



caaacattga gagcagatcc gatgttccca ccagaatcca aacaaaagga ctatgaagaa     1620



aattcttggg attctgagag tctctgtgag actgtttcac agaaggatgt gtgtttaccc     1680



aaggctacac atcaaaaaga aatagataaa ataaatggaa aattagaaga gtctcctaat     1740



aaagatggtc ttctgaaggc tacctgcgga atgaaagttt ctattccaac taaagcctta     1800



gaattgaagg acatgcaaac tttcaaagca gagcctccgg ggaagccatc tgccttcgag     1860



cctgccactg aaatgcaaaa gtctgtccca aataaagcct tggaattgaa aaatgaacaa     1920



acattgagag cagatgagat actcccatca gaatccaaac aaaaggacta tgaagaaaat     1980



tcttgggata ctgagagtct ctgtgagact gtttcacaga aggatgtgtg tttacccaag     2040



gctgcgcatc aaaaagaaat agataaaata aatggaaaat tagaagggtc tcctgttaaa     2100



gatggtcttc tgaaggctaa ctgcggaatg aaagtttcta ttccaactaa agccttagaa     2160



ttgatggaca tgcaaacttt caaagcagag cctcccgaga agccatctgc cttcgagcct     2220



gccattgaaa tgcaaaagtc tgttccaaat aaagccttgg aattgaagaa tgaacaaaca     2280



ttgagagcag atgagatact cccatcagaa tccaaacaaa aggactatga agaaagttct     2340



tgggattctg agagtctctg tgagactgtt tcacagaagg atgtgtgttt acccaaggct     2400



acgcatcaaa aagaaataga taaaataaat ggaaaattag aagagtctcc tgataatgat     2460



ggttttctga aggctccctg cagaatgaaa gtttctattc caactaaagc cttagaattg     2520



atggacatgc aaactttcaa agcagagcct cccgagaagc catctgcctt cgagcctgcc     2580



attgaaatgc aaaagtctgt tccaaataaa gccttggaat tgaagaatga acaaacattg     2640



agagcagatc agatgttccc ttcagaatca aaacaaaaga aggttgaaga aaattcttgg     2700



gattctgaga gtctccgtga gactgtttca cagaaggatg tgtgtgtacc caaggctaca     2760



catcaaaaag aaatggataa aataagtgga aaattagaag attcaactag cctatcaaaa     2820



atcttggata cagttcattc ttgtgaaaga gcaagggaac ttcaaaaaga tcactgtgaa     2880



caacgtacag gaaaaatgga acaaatgaaa aagaagtttt gtgtactgaa aaagaaactg     2940



tcagaagcaa aagaaataaa atcacagtta gagaaccaaa aagttaaatg ggaacaagag     3000



ctctgcagtg tgagattgac tttaaaccaa gaagaagaga agagaagaaa tgccgatata     3060



ttaaatgaaa aaattaggga agaattagga agaatcgaag agcagcatag gaaagagtta     3120



gaagtgaaac aacaacttga acaggctctc agaatacaag atatagaatt gaagagtgta     3180



gaaagtaatt tgaatcaggt ttctcacact catgaaaatg aaaattatct cttacatgaa     3240



aattgcatgt tgaaaaagga aattgccatg ctaaaactgg aaatagccac actgaaacac     3300



caataccagg aaaaggaaaa taaatacttt gaggacatta agattttaaa agaaaagaat     3360



gctgaacttc agatgaccct aaaactgaaa gaggaatcat taactaaaag ggcatctcaa     3420



tatagtgggc agcttaaagt tctgatagct gagaacacaa tgctcacttc taaattgaag     3480



gaaaaacaag acaaagaaat actagaggca gaaattgaat cacaccatcc tagactggct     3540



tctgctgtac aagaccatga tcaaattgtg acatcaagaa aaagtcaaga acctgctttc     3600



cacattgcag gagatgcttg tttgcaaaga aaaatgaatg ttgatgtgag tagtacgata     3660



tataacaatg aggtgctcca tcaaccactt tctgaagctc aaaggaaatc caaaagccta     3720



aaaattaatc tcaattatgc aggagatgct ctaagagaaa atacattggt ttcagaacat     3780



gcacaaagag accaacgtga aacacagtgt caaatgaagg aagctgaaca catgtatcaa     3840



aacgaacaag ataatgtgaa caaacacact gaacagcagg agtctctaga tcagaaatta     3900



tttcaactac aaagcaaaaa tatgtggctt caacagcaat tagttcatgc acataagaaa     3960



gctgacaaca aaagcaagat aacaattgat attcattttc ttgagaggaa aatgcaacat     4020



catctcctaa aagagaaaaa tgaggagata tttaattaca ataaccattt aaaaaaccgt     4080



atatatcaat atgaaaaaga gaaagcagaa acagaaaact catgagagac aagcagtaag     4140



aaacttcttt tggagaaaca acagaccaga tctttactca caactcatgc taggaggcca     4200



gtcctagcat caccttatgt tgaaaatctt accaatagtc tgtgtcaaca gaatacttat     4260



tttagaagaa aaattcatga tttcttcctg aagcctacag acataaaata acagtgtgaa     4320



gaattacttg ttcacgaatt gcataaagct gcacaggatt cccatctacc ctgatgatgc     4380



agcagacatc attcaatcca accag                                           4405





<210>  18

<211>  1341

<212>  PRT

<213>  Homo sapiens



<400>  18



Met Thr Lys Arg Lys Lys Thr Ile Asn Leu Asn Ile Gln Asp Ala Gln 

1               5                   10                  15      





Lys Arg Thr Ala Leu His Trp Ala Cys Val Asn Gly His Glu Glu Val 

            20                  25                  30          





Val Thr Phe Leu Val Asp Arg Lys Cys Gln Leu Asp Val Leu Asp Gly 

        35                  40                  45              





Glu His Arg Thr Pro Leu Met Lys Ala Leu Gln Cys His Gln Glu Ala 

    50                  55                  60                  





Cys Ala Asn Ile Leu Ile Asp Ser Gly Ala Asp Ile Asn Leu Val Asp 

65                  70                  75                  80  





Val Tyr Gly Asn Thr Ala Leu His Tyr Ala Val Tyr Ser Glu Ile Leu 

                85                  90                  95      





Ser Val Val Ala Lys Leu Leu Ser His Gly Ala Val Ile Glu Val His 

            100                 105                 110         





Asn Lys Ala Ser Leu Thr Pro Leu Leu Leu Ser Ile Thr Lys Arg Ser 

        115                 120                 125             





Glu Gln Ile Val Glu Phe Leu Leu Ile Lys Asn Ala Asn Ala Asn Ala 

    130                 135                 140                 





Val Asn Lys Tyr Lys Cys Thr Ala Leu Met Leu Ala Val Cys His Gly 

145                 150                 155                 160 





Ser Ser Glu Ile Val Gly Met Leu Leu Gln Gln Asn Val Asp Val Phe 

                165                 170                 175     





Ala Ala Asp Ile Cys Gly Val Thr Ala Glu His Tyr Ala Val Thr Cys 

            180                 185                 190         





Gly Phe His His Ile His Glu Gln Ile Met Glu Tyr Ile Arg Lys Leu 

        195                 200                 205             





Ser Lys Asn His Gln Asn Thr Asn Pro Glu Gly Thr Ser Ala Gly Thr 

    210                 215                 220                 





Pro Asp Glu Ala Ala Pro Leu Ala Glu Arg Thr Pro Asp Thr Ala Glu 

225                 230                 235                 240 





Ser Leu Val Glu Lys Thr Pro Asp Glu Ala Ala Pro Leu Val Glu Arg 

                245                 250                 255     





Thr Pro Asp Thr Ala Glu Ser Leu Val Glu Lys Thr Pro Asp Glu Ala 

            260                 265                 270         





Ala Ser Leu Val Glu Gly Thr Ser Asp Lys Ile Gln Cys Leu Glu Lys 

        275                 280                 285             





Ala Thr Ser Gly Lys Phe Glu Gln Ser Ala Glu Glu Thr Pro Arg Glu 

    290                 295                 300                 





Ile Thr Ser Pro Ala Lys Glu Thr Ser Glu Lys Phe Thr Trp Pro Ala 

305                 310                 315                 320 





Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Asp Thr Pro 

                325                 330                 335     





Arg Glu Ile Met Ser Pro Ala Lys Glu Thr Ser Glu Lys Phe Thr Trp 

            340                 345                 350         





Ala Ala Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Thr 

        355                 360                 365             





Pro Val Lys Thr Gly Cys Val Ala Arg Val Thr Ser Asn Lys Thr Lys 

    370                 375                 380                 





Val Leu Glu Lys Gly Arg Ser Lys Met Ile Ala Cys Pro Thr Lys Glu 

385                 390                 395                 400 





Ser Ser Thr Lys Ala Ser Ala Asn Asp Gln Arg Phe Pro Ser Glu Ser 

                405                 410                 415     





Lys Gln Glu Glu Asp Glu Glu Tyr Ser Cys Asp Ser Arg Ser Leu Phe 

            420                 425                 430         





Glu Ser Ser Ala Lys Ile Gln Val Cys Ile Pro Glu Ser Ile Tyr Gln 

        435                 440                 445             





Lys Val Met Glu Ile Asn Arg Glu Val Glu Glu Pro Pro Lys Lys Pro 

    450                 455                 460                 





Ser Ala Phe Lys Pro Ala Ile Glu Met Gln Asn Ser Val Pro Asn Lys 

465                 470                 475                 480 





Ala Phe Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp Pro Met Phe 

                485                 490                 495     





Pro Pro Glu Ser Lys Gln Lys Asp Tyr Glu Glu Asn Ser Trp Asp Ser 

            500                 505                 510         





Glu Ser Leu Cys Glu Thr Val Ser Gln Lys Asp Val Cys Leu Pro Lys 

        515                 520                 525             





Ala Thr His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu 

    530                 535                 540                 





Ser Pro Asn Lys Asp Gly Leu Leu Lys Ala Thr Cys Gly Met Lys Val 

545                 550                 555                 560 





Ser Ile Pro Thr Lys Ala Leu Glu Leu Lys Asp Met Gln Thr Phe Lys 

                565                 570                 575     





Ala Glu Pro Pro Gly Lys Pro Ser Ala Phe Glu Pro Ala Thr Glu Met 

            580                 585                 590         





Gln Lys Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Thr 

        595                 600                 605             





Leu Arg Ala Asp Glu Ile Leu Pro Ser Glu Ser Lys Gln Lys Asp Tyr 

    610                 615                 620                 





Glu Glu Asn Ser Trp Asp Thr Glu Ser Leu Cys Glu Thr Val Ser Gln 

625                 630                 635                 640 





Lys Asp Val Cys Leu Pro Lys Ala Ala His Gln Lys Glu Ile Asp Lys 

                645                 650                 655     





Ile Asn Gly Lys Leu Glu Gly Ser Pro Val Lys Asp Gly Leu Leu Lys 

            660                 665                 670         





Ala Asn Cys Gly Met Lys Val Ser Ile Pro Thr Lys Ala Leu Glu Leu 

        675                 680                 685             





Met Asp Met Gln Thr Phe Lys Ala Glu Pro Pro Glu Lys Pro Ser Ala 

    690                 695                 700                 





Phe Glu Pro Ala Ile Glu Met Gln Lys Ser Val Pro Asn Lys Ala Leu 

705                 710                 715                 720 





Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp Glu Ile Leu Pro Ser 

                725                 730                 735     





Glu Ser Lys Gln Lys Asp Tyr Glu Glu Ser Ser Trp Asp Ser Glu Ser 

            740                 745                 750         





Leu Cys Glu Thr Val Ser Gln Lys Asp Val Cys Leu Pro Lys Ala Thr 

        755                 760                 765             





His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu Ser Pro 

    770                 775                 780                 





Asp Asn Asp Gly Phe Leu Lys Ala Pro Cys Arg Met Lys Val Ser Ile 

785                 790                 795                 800 





Pro Thr Lys Ala Leu Glu Leu Met Asp Met Gln Thr Phe Lys Ala Glu 

                805                 810                 815     





Pro Pro Glu Lys Pro Ser Ala Phe Glu Pro Ala Ile Glu Met Gln Lys 

            820                 825                 830         





Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Thr Leu Arg 

        835                 840                 845             





Ala Asp Gln Met Phe Pro Ser Glu Ser Lys Gln Lys Lys Val Glu Glu 

    850                 855                 860                 





Asn Ser Trp Asp Ser Glu Ser Leu Arg Glu Thr Val Ser Gln Lys Asp 

865                 870                 875                 880 





Val Cys Val Pro Lys Ala Thr His Gln Lys Glu Met Asp Lys Ile Ser 

                885                 890                 895     





Gly Lys Leu Glu Asp Ser Thr Ser Leu Ser Lys Ile Leu Asp Thr Val 

            900                 905                 910         





His Ser Cys Glu Arg Ala Arg Glu Leu Gln Lys Asp His Cys Glu Gln 

        915                 920                 925             





Arg Thr Gly Lys Met Glu Gln Met Lys Lys Lys Phe Cys Val Leu Lys 

    930                 935                 940                 





Lys Lys Leu Ser Glu Ala Lys Glu Ile Lys Ser Gln Leu Glu Asn Gln 

945                 950                 955                 960 





Lys Val Lys Trp Glu Gln Glu Leu Cys Ser Val Arg Leu Thr Leu Asn 

                965                 970                 975     





Gln Glu Glu Glu Lys Arg Arg Asn Ala Asp Ile Leu Asn Glu Lys Ile 

            980                 985                 990         





Arg Glu Glu Leu Gly Arg Ile Glu  Glu Gln His Arg Lys  Glu Leu Glu 

        995                 1000                 1005             





Val Lys  Gln Gln Leu Glu Gln  Ala Leu Arg Ile Gln  Asp Ile Glu 

    1010                 1015                 1020             





Leu Lys  Ser Val Glu Ser Asn  Leu Asn Gln Val Ser  His Thr His 

    1025                 1030                 1035             





Glu Asn  Glu Asn Tyr Leu Leu  His Glu Asn Cys Met  Leu Lys Lys 

    1040                 1045                 1050             





Glu Ile  Ala Met Leu Lys Leu  Glu Ile Ala Thr Leu  Lys His Gln 

    1055                 1060                 1065             





Tyr Gln  Glu Lys Glu Asn Lys  Tyr Phe Glu Asp Ile  Lys Ile Leu 

    1070                 1075                 1080             





Lys Glu  Lys Asn Ala Glu Leu  Gln Met Thr Leu Lys  Leu Lys Glu 

    1085                 1090                 1095             





Glu Ser  Leu Thr Lys Arg Ala  Ser Gln Tyr Ser Gly  Gln Leu Lys 

    1100                 1105                 1110             





Val Leu  Ile Ala Glu Asn Thr  Met Leu Thr Ser Lys  Leu Lys Glu 

    1115                 1120                 1125             





Lys Gln  Asp Lys Glu Ile Leu  Glu Ala Glu Ile Glu  Ser His His 

    1130                 1135                 1140             





Pro Arg  Leu Ala Ser Ala Val  Gln Asp His Asp Gln  Ile Val Thr 

    1145                 1150                 1155             





Ser Arg  Lys Ser Gln Glu Pro  Ala Phe His Ile Ala  Gly Asp Ala 

    1160                 1165                 1170             





Cys Leu  Gln Arg Lys Met Asn  Val Asp Val Ser Ser  Thr Ile Tyr 

    1175                 1180                 1185             





Asn Asn  Glu Val Leu His Gln  Pro Leu Ser Glu Ala  Gln Arg Lys 

    1190                 1195                 1200             





Ser Lys  Ser Leu Lys Ile Asn  Leu Asn Tyr Ala Gly  Asp Ala Leu 

    1205                 1210                 1215             





Arg Glu  Asn Thr Leu Val Ser  Glu His Ala Gln Arg  Asp Gln Arg 

    1220                 1225                 1230             





Glu Thr  Gln Cys Gln Met Lys  Glu Ala Glu His Met  Tyr Gln Asn 

    1235                 1240                 1245             





Glu Gln  Asp Asn Val Asn Lys  His Thr Glu Gln Gln  Glu Ser Leu 

    1250                 1255                 1260             





Asp Gln  Lys Leu Phe Gln Leu  Gln Ser Lys Asn Met  Trp Leu Gln 

    1265                 1270                 1275             





Gln Gln  Leu Val His Ala His  Lys Lys Ala Asp Asn  Lys Ser Lys 

    1280                 1285                 1290             





Ile Thr  Ile Asp Ile His Phe  Leu Glu Arg Lys Met  Gln His His 

    1295                 1300                 1305             





Leu Leu  Lys Glu Lys Asn Glu  Glu Ile Phe Asn Tyr  Asn Asn His 

    1310                 1315                 1320             





Leu Lys  Asn Arg Ile Tyr Gln  Tyr Glu Lys Glu Lys  Ala Glu Thr 

    1325                 1330                 1335             





Glu Asn  Ser 

    1340     





<210>  19

<211>  3473

<212>  DNA

<213>  Homo sapiens



<400>  19

gcccattgga cagaatacaa aggcagaaac ctaccccgaa ggccggggcc cggcggggcg       60



ctgggggtgg gcgctccccg cggcccccgg cgcccttcgc cccgagacgc cccggcccag      120



cggcactggc gcgaccgagg tccagcttcg gggacacgcc cggctggccg cggggaaggc      180



accaggtgag cgcggccgcg cctcccggaa ccccgctccc gcgcgtcccg cggcgacgcg      240



gcgcccaccc gccccgggag ccaggaaccc agggccccac catggcgctg gccgccgccg      300



ccgccgctgc ggctgccggg gtgagccagg cggcggtgct gggcttcctg caggagcacg      360



gcgggaaggt gcgcaactcc gagctgctga gccgcttcaa gccgctgctc gatgccggcg      420



acccgcgggg ccgcgccgcc cgcagggacc gcttcaagca gttcgtcaac aacgtggcgg      480



tggtgaagga gctcgacggc gtcaagttcg tggtgctgag gaagaagccc cggcccccgg      540



agcccgagcc cgcacccttc ggccccccgg gggcagcggc ccagccgtcg aaacccactt      600



cgacggtctt gccgcggagc gcctctgccc cgggagctcc gcccttggtc cgggtgccgc      660



ggccagtgga gccgccaggg gacctgggtc tgccaacaga gccacaggac accccggggg      720



ggccggcctc cgagcccgct cagccgcccg gggagcggtc cgccgaccca ccgcttccag      780



cccttgagct agcccaggcc accgagagac cctccgcaga cgcggcccca ccgcctaggg      840



ccccttctga ggcggcatcg ccctgctctg atccgccaga cgcggagccc gggcccgggg      900



cagcgaaagg gccgccgcag cagaagccct gtatgctgcc ggtgcgctgc gtcccggccc      960



ccgccacgct ccgcctccgg gcggaggagc ccggcctgcg ccggcagctg tcggaggagc     1020



cgagcccgcg gagctcccct ctgctgctga ggcggctctc ggtggaagag tccggtctgg     1080



gcctcggcct gggcccgggc cgctccccgc acctgaggcg cctgtcgcgc gccggcccgc     1140



gtctgctgag ccctgacgcc gaggagttgc ccgccgcgcc gccgccgtcc gcggtgcccc     1200



tggagccgtc cgagcacgag tggctcgtgc ggactgccgg gggccgctgg acccaccagc     1260



tgcacgggct gctgctgcgc gaccgcggct tggcggccaa gcgcgacttc atgtctggct     1320



tcacggccct gcattgggcc gccaagagcg gcgacggcga gatggcgctg cagctggtgg     1380



aggtcgcgcg gcgcagtggc gcaccagtcg acgtgaacgc acgctcccac ggcggctaca     1440



cgccgctgca cctggctgca ctgcacggcc acgaggacgc tgccgtgctg ctggtggtgc     1500



gtctgggtgc ccaggtgcac gtgcgtgatc acagcgggcg tcgcgcctac cagtacctgc     1560



ggcccggctc ctcgtacgcg ctgcgccgcc ttcttggcga tccaggcctg cgaggcacca     1620



cggagccaga tgcgaccggt ggtggaagtg gcagtcttgc tgccaggcgc cccgtacagg     1680



tggccgccac catcctcagt tccaccacca gtgcatttct gggcgtcctg gctgacgacc     1740



tcatgctcca ggacctggcc cgaggcttga agaagtcgag ctccttcagc aagttcttga     1800



gcgcctcgcc catggctcca cgtaaaaaga caaagatccg cggtggtctg ccagccttct     1860



cagaaatctc tcgtcgacct actccggggc ctttagctgg tctagtgccc agttttcctc     1920



caacaacctg aaggtccctg gggctaccac ctggttgatc tatcgtggcc tgctcgtcgc     1980



agtccaaacc cgcccaagac tgcagcccaa tcaacgcctg gagcctcatt ctgtttccag     2040



ctttgtccag ggcagcctgt tttacccaga tgggcctgca cctccagctt ctttctgaag     2100



catgacccat ctccagagat gggatttgag aaatcagtga gagcttccta taaagaactc     2160



caggagacag gcctgaactc tagagggaac ttgaaatcca gggtcaaagg ttaaggggca     2220



gcagctggtc tggcccctga aagccttcac ctgatgcctc tgcagctaca caatcccaag     2280



acagagctag agcaagggtc tctttaaatg ttgaaagatg ttaggttgtc agctttaaga     2340



tatgtggtgg ttttgtaatt tgatgctttt attctgtttt taaattgaaa tgaggtaatg     2400



caactttcgt aataaccttt tggaattata tttttccact tttaggcaaa gtgcttagac     2460



attttcaatt ttttttttgc taaatacttt ggaattctat ttaaaaaata gatgatcaag     2520



atctaaagga aattaatccc aaccaacaaa cttaaaagtt tatctacctc gttttaggca     2580



atcaagattc tggagagtct tgaacacaga ataacgattg tgaccattat gaatgtaact     2640



aatttcagtt gtactgtgaa tgctaaatat ttgcaaacaa gtacatcttg aaagtaaagg     2700



tgacttagag aaaagagaca ttttgacaga tacttttaat ttgtggttgt ctccatcatg     2760



aaatagaaac gtgtttggca cttgtgggtg gctattttga tttggcatga ctacttaatt     2820



ttttaaaaaa attgtggttt gtgaattgca cctttgtgcc atgtttctga atctggtttt     2880



caaatccagt ggagcctttc agtgaaatag gtgactatta aaaaagtaat agtattacag     2940



aaaaatgagc gattaaatag taatggatac aattaaggag caactatttt atatgactgt     3000



tctgtacaaa caaaaagtat gtaataccca ttttaaaaaa ccatttgaaa gtagacaact     3060



tattccaaaa tagcaaatgc agaatctctg ctcagtgagc ttggatgagt ggcttaactt     3120



ctctgggcct ttgttcctat ctgtaaatga gaaagtttgt agatattgcc aagatttccc     3180



aggctcaata cagtgtaatt attttatgtt ttaaagatat gaaatctgtt tactcaacca     3240



attttttaaa tgtcatattg tgataatgct ctgcttttgc aaattgtgtt tgcatgtcat     3300



tagttatatc aaatagtttt gtggcatggg gtagtggagc ttccctcccc acccccatat     3360



gtatcagtga agcctttgaa attacttaag gcagtctttc atggaatgtt ttgattgagc     3420



aatgaaataa acagtcctcc attttgtttc tgcttgaaaa aaaaaaaaaa aaa            3473





<210>  20

<211>  549

<212>  PRT

<213>  Homo sapiens



<400>  20



Met Ala Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Ser Gln 

1               5                   10                  15      





Ala Ala Val Leu Gly Phe Leu Gln Glu His Gly Gly Lys Val Arg Asn 

            20                  25                  30          





Ser Glu Leu Leu Ser Arg Phe Lys Pro Leu Leu Asp Ala Gly Asp Pro 

        35                  40                  45              





Arg Gly Arg Ala Ala Arg Arg Asp Arg Phe Lys Gln Phe Val Asn Asn 

    50                  55                  60                  





Val Ala Val Val Lys Glu Leu Asp Gly Val Lys Phe Val Val Leu Arg 

65                  70                  75                  80  





Lys Lys Pro Arg Pro Pro Glu Pro Glu Pro Ala Pro Phe Gly Pro Pro 

                85                  90                  95      





Gly Ala Ala Ala Gln Pro Ser Lys Pro Thr Ser Thr Val Leu Pro Arg 

            100                 105                 110         





Ser Ala Ser Ala Pro Gly Ala Pro Pro Leu Val Arg Val Pro Arg Pro 

        115                 120                 125             





Val Glu Pro Pro Gly Asp Leu Gly Leu Pro Thr Glu Pro Gln Asp Thr 

    130                 135                 140                 





Pro Gly Gly Pro Ala Ser Glu Pro Ala Gln Pro Pro Gly Glu Arg Ser 

145                 150                 155                 160 





Ala Asp Pro Pro Leu Pro Ala Leu Glu Leu Ala Gln Ala Thr Glu Arg 

                165                 170                 175     





Pro Ser Ala Asp Ala Ala Pro Pro Pro Arg Ala Pro Ser Glu Ala Ala 

            180                 185                 190         





Ser Pro Cys Ser Asp Pro Pro Asp Ala Glu Pro Gly Pro Gly Ala Ala 

        195                 200                 205             





Lys Gly Pro Pro Gln Gln Lys Pro Cys Met Leu Pro Val Arg Cys Val 

    210                 215                 220                 





Pro Ala Pro Ala Thr Leu Arg Leu Arg Ala Glu Glu Pro Gly Leu Arg 

225                 230                 235                 240 





Arg Gln Leu Ser Glu Glu Pro Ser Pro Arg Ser Ser Pro Leu Leu Leu 

                245                 250                 255     





Arg Arg Leu Ser Val Glu Glu Ser Gly Leu Gly Leu Gly Leu Gly Pro 

            260                 265                 270         





Gly Arg Ser Pro His Leu Arg Arg Leu Ser Arg Ala Gly Pro Arg Leu 

        275                 280                 285             





Leu Ser Pro Asp Ala Glu Glu Leu Pro Ala Ala Pro Pro Pro Ser Ala 

    290                 295                 300                 





Val Pro Leu Glu Pro Ser Glu His Glu Trp Leu Val Arg Thr Ala Gly 

305                 310                 315                 320 





Gly Arg Trp Thr His Gln Leu His Gly Leu Leu Leu Arg Asp Arg Gly 

                325                 330                 335     





Leu Ala Ala Lys Arg Asp Phe Met Ser Gly Phe Thr Ala Leu His Trp 

            340                 345                 350         





Ala Ala Lys Ser Gly Asp Gly Glu Met Ala Leu Gln Leu Val Glu Val 

        355                 360                 365             





Ala Arg Arg Ser Gly Ala Pro Val Asp Val Asn Ala Arg Ser His Gly 

    370                 375                 380                 





Gly Tyr Thr Pro Leu His Leu Ala Ala Leu His Gly His Glu Asp Ala 

385                 390                 395                 400 





Ala Val Leu Leu Val Val Arg Leu Gly Ala Gln Val His Val Arg Asp 

                405                 410                 415     





His Ser Gly Arg Arg Ala Tyr Gln Tyr Leu Arg Pro Gly Ser Ser Tyr 

            420                 425                 430         





Ala Leu Arg Arg Leu Leu Gly Asp Pro Gly Leu Arg Gly Thr Thr Glu 

        435                 440                 445             





Pro Asp Ala Thr Gly Gly Gly Ser Gly Ser Leu Ala Ala Arg Arg Pro 

    450                 455                 460                 





Val Gln Val Ala Ala Thr Ile Leu Ser Ser Thr Thr Ser Ala Phe Leu 

465                 470                 475                 480 





Gly Val Leu Ala Asp Asp Leu Met Leu Gln Asp Leu Ala Arg Gly Leu 

                485                 490                 495     





Lys Lys Ser Ser Ser Phe Ser Lys Phe Leu Ser Ala Ser Pro Met Ala 

            500                 505                 510         





Pro Arg Lys Lys Thr Lys Ile Arg Gly Gly Leu Pro Ala Phe Ser Glu 

        515                 520                 525             





Ile Ser Arg Arg Pro Thr Pro Gly Pro Leu Ala Gly Leu Val Pro Ser 

    530                 535                 540                 





Phe Pro Pro Thr Thr 

545                 





<210>  21

<211>  1626

<212>  DNA

<213>  Homo sapiens



<400>  21

gacggtcccg ctgtcctgcc tggccggggc cgcactgcgc cgcccgccgc ccgccgcccg       60



ccgcccgccg ccggcgacgg caccgccgcc ctgcgatccg gccgcggcgg ctcagagcgc      120



ggctgcggcg ggcgcgggcg gcggtggctc cctcccgtgc gtccgtcgtg ggacctttgc      180



ccgctcgccc gcgggggaca gcgcgcgctc cggtccgcgg caggggcggg gacgcccggc      240



ctgtggcccc cgcgcccccc atggcctggc tctgccgtgg cttgctgacc ttggagaatt      300



ggagaagctt gtgccctgct ggaaagtggg atggcagtac ccgcttcatc tagtagtcgg      360



ggagatcaag agaggtatgg gacctgaaga ggatggcaga ctgtgcagtg cggtgcacac      420



cggtctccag gttgttttca ccctcctatc tcctcccagg agctaacgta taaagctgag      480



gctcggccag ggactgtgat atacccacat ccccggaact aggtgatcgc ggtgcaggaa      540



ccaggtgtgc cttcgcggga tccatgcctt gaggcccagg aacgccccgc cgccagcatg      600



ccgtgggacg cgcggcggcc tgggggtggc gcggacggcg ggcccgaggc ctcgggcgcg      660



gcgcgctcgc gagcgcagaa gcagtgccgc aagtcgtcgt tcgccttcta ccaggcggtg      720



cgcgacctgc tacccgtgtg gctgctggag gatatgcgcg ccagcgaggc cttccactgg      780



gacgagcgcg ggcgcgccgc cgcctactcg ccctctgagg cgctgctcta cgcgctcgtg      840



cacgaccacc aagcgtacgc gcattacctg ctggccacgt tcccgcggcg cgcgctcgca      900



ccgcccagtg ccggcttccg ctgctgcgcg gctcccgggc cgcacgtggc gctggcagtg      960



cgctacaacc gcgtgggcat tctgcgccgc atcctgcgca ccttgcgcga cttcccggcc     1020



gaggagcggg cgcgcgtgct ggaccggcgt ggctgcagcc gcgtggaggg cggtggcacg     1080



tcgctgcacg tggcctgtga gctggcgcgc cccgagtgcc tcttcctgct gctgggccac     1140



ggcgcctcgc ccggtctgcg ggacggcggc ggcctcacgc ctctcgagct gctgctgcgc     1200



cagctgggcc gcgacgccgg ggccactccc tccgccgccg gagcccccgc ctcagctccc     1260



ggggagccgc gccagcgccg cctgctgctg ctggacctcc tggcgctgta cacccccgtg     1320



ggtgccgccg gctcggcccg ccaggagctg ctgggcgacc ggccgcgctg gcagcggctg     1380



ctgggtgagg acaagttcca gtggctggcg ggcctggcgc cgccctcgct cttcgcgcgc     1440



gccatgcagg tgctggtcac cgccatctct ccaggccgct tccccgaggc cctggacgag     1500



ctgccgctgc ccccattcct gcagccgttg gacctcactg gcaaaggcta ggcccggagc     1560



accctaggcg ctggattttg ggacaaaact atttttcaga gcgttgtacc ggcactttat     1620



atatat                                                                1626





<210>  22

<211>  317

<212>  PRT

<213>  Homo sapiens



<400>  22



Met Pro Trp Asp Ala Arg Arg Pro Gly Gly Gly Ala Asp Gly Gly Pro 

1               5                   10                  15      





Glu Ala Ser Gly Ala Ala Arg Ser Arg Ala Gln Lys Gln Cys Arg Lys 

            20                  25                  30          





Ser Ser Phe Ala Phe Tyr Gln Ala Val Arg Asp Leu Leu Pro Val Trp 

        35                  40                  45              





Leu Leu Glu Asp Met Arg Ala Ser Glu Ala Phe His Trp Asp Glu Arg 

    50                  55                  60                  





Gly Arg Ala Ala Ala Tyr Ser Pro Ser Glu Ala Leu Leu Tyr Ala Leu 

65                  70                  75                  80  





Val His Asp His Gln Ala Tyr Ala His Tyr Leu Leu Ala Thr Phe Pro 

                85                  90                  95      





Arg Arg Ala Leu Ala Pro Pro Ser Ala Gly Phe Arg Cys Cys Ala Ala 

            100                 105                 110         





Pro Gly Pro His Val Ala Leu Ala Val Arg Tyr Asn Arg Val Gly Ile 

        115                 120                 125             





Leu Arg Arg Ile Leu Arg Thr Leu Arg Asp Phe Pro Ala Glu Glu Arg 

    130                 135                 140                 





Ala Arg Val Leu Asp Arg Arg Gly Cys Ser Arg Val Glu Gly Gly Gly 

145                 150                 155                 160 





Thr Ser Leu His Val Ala Cys Glu Leu Ala Arg Pro Glu Cys Leu Phe 

                165                 170                 175     





Leu Leu Leu Gly His Gly Ala Ser Pro Gly Leu Arg Asp Gly Gly Gly 

            180                 185                 190         





Leu Thr Pro Leu Glu Leu Leu Leu Arg Gln Leu Gly Arg Asp Ala Gly 

        195                 200                 205             





Ala Thr Pro Ser Ala Ala Gly Ala Pro Ala Ser Ala Pro Gly Glu Pro 

    210                 215                 220                 





Arg Gln Arg Arg Leu Leu Leu Leu Asp Leu Leu Ala Leu Tyr Thr Pro 

225                 230                 235                 240 





Val Gly Ala Ala Gly Ser Ala Arg Gln Glu Leu Leu Gly Asp Arg Pro 

                245                 250                 255     





Arg Trp Gln Arg Leu Leu Gly Glu Asp Lys Phe Gln Trp Leu Ala Gly 

            260                 265                 270         





Leu Ala Pro Pro Ser Leu Phe Ala Arg Ala Met Gln Val Leu Val Thr 

        275                 280                 285             





Ala Ile Ser Pro Gly Arg Phe Pro Glu Ala Leu Asp Glu Leu Pro Leu 

    290                 295                 300                 





Pro Pro Phe Leu Gln Pro Leu Asp Leu Thr Gly Lys Gly 

305                 310                 315         





<210>  23

<211>  1952

<212>  DNA

<213>  Homo sapiens



<400>  23

ggcggcggca ctgcggtgaa agccgaggca gcgggcagac gagcaggggg cgggcggaca       60



tcttgggatc cggagagtgg ccgggccggc agagcagggg gccgaggaca ccaggtctgt      120



tctcagagcg atgggccgcg gagactgatc tgccgccatg attggaggct tattcatcta      180



taatcacaag ggggaggtgc tcatctcccg agtctaccga gatgacatcg ggaggaacgc      240



agtggatgcc tttcgggtca atgttatcca tgcccggcag caggtgcgca gccccgtcac      300



caacattgct cgcaccagct tcttccacgt taagcggtcc aacatttggc tggcagcagt      360



caccaagcag aatgtcaacg ctgccatggt cttcgaattc ctctataaga tgtgtgacgt      420



gatggctgcc tactttggca agatcagcga ggaaaacatc aagaacaatt ttgtgctcat      480



atatgagctg ctggatgaga ttctagactt tggctaccca cagaattccg agacaggcgc      540



gctgaaaacc ttcatcacgc agcagggcat caagagtcag acaaaagaag agcagtcaca      600



gatcaccagc caggtaactg ggcagattgg ctggcggcga gagggtatca agtatcgtcg      660



gaatgagctc ttcctggatg tgctggagag tgtgaacctg ctcatgtccc cacaagggca      720



ggtgctgagt gcccatgtgt cgggccgggt ggtgatgaag agctacctga gtggcatgcc      780



tgaatgcaag tttgggatga atgacaagat tgttattgaa aagcagggca aaggcacagc      840



tgatgaaaca agcaagagcg ggaagcaatc aattgccatt gatgactgca ccttccacca      900



gtgtgtgcga ctcagcaagt ttgactctga acgcagcatc agctttatcc cgccagatgg      960



agagtttgag cttatgaggt atcgcacaac caaggacatc atccttccct tccgggtgat     1020



cccgctagtg cgagaagtgg gacgcaccaa actggaggtc aaggtggtca tcaagtccaa     1080



ctttaaaccc tcactgctgg ctcagaagat cgaggtgagg atcccaaccc cactgaacac     1140



aagcggggtg caggtgatct gcatgaaggg gaaggccaag tacaaggcca gcgagaatgc     1200



catcgtgtgg aagatcaagc gcatggcagg catgaaggaa tcgcagatca gcgcagagat     1260



tgagcttctg cctaccaacg acaagaagaa atgggctcga ccccccattt ccatgaactt     1320



tgaggtgcca ttcgcgccct ctggcctcaa ggtgcgctac ttgaaggtgt ttgaaccgaa     1380



gctgaactac agcgaccatg atgtcatcaa atgggtgcgc tacattggcc gcagtggcat     1440



ttatgaaact cgctgctagc tgccactagg cagctagccc acctccccag ccaccctcct     1500



ccacaggtcc aggtgccgct ccctccccca ccacacatca gtgtctcctc cctcctgctt     1560



tgctgccttc cctttgcacc agcccgagtc taggtctggg ccaagcacat tacaagtggg     1620



accggtggag cagcccctgg gctccctggg caggggagtt ctgaggctcc tgctctccca     1680



tccacctgtc tgtcctggcc taatgccagg ctctgagttc tgtgaccaaa gccaggtggg     1740



ttccctttcc ttcccacccc tgtggccaca gctctggagt gggagggttg gttgcccctc     1800



acctcagagc tcccccaaag gccagtaatg gatccccggc ctcagtccct actctgcttt     1860



gggatagtgt gagcttcatt ttgtacacgt gtgacttcgt ccagttacaa acccaataaa     1920



ctctgtagag tggaaaaaaa aaaaaaaaaa aa                                   1952





<210>  24

<211>  433

<212>  PRT

<213>  Homo sapiens



<400>  24



Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 

1               5                   10                  15      





Ser Arg Val Tyr Arg Asp Asp Ile Gly Arg Asn Ala Val Asp Ala Phe 

            20                  25                  30          





Arg Val Asn Val Ile His Ala Arg Gln Gln Val Arg Ser Pro Val Thr 

        35                  40                  45              





Asn Ile Ala Arg Thr Ser Phe Phe His Val Lys Arg Ser Asn Ile Trp 

    50                  55                  60                  





Leu Ala Ala Val Thr Lys Gln Asn Val Asn Ala Ala Met Val Phe Glu 

65                  70                  75                  80  





Phe Leu Tyr Lys Met Cys Asp Val Met Ala Ala Tyr Phe Gly Lys Ile 

                85                  90                  95      





Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Leu Ile Tyr Glu Leu Leu 

            100                 105                 110         





Asp Glu Ile Leu Asp Phe Gly Tyr Pro Gln Asn Ser Glu Thr Gly Ala 

        115                 120                 125             





Leu Lys Thr Phe Ile Thr Gln Gln Gly Ile Lys Ser Gln Thr Lys Glu 

    130                 135                 140                 





Glu Gln Ser Gln Ile Thr Ser Gln Val Thr Gly Gln Ile Gly Trp Arg 

145                 150                 155                 160 





Arg Glu Gly Ile Lys Tyr Arg Arg Asn Glu Leu Phe Leu Asp Val Leu 

                165                 170                 175     





Glu Ser Val Asn Leu Leu Met Ser Pro Gln Gly Gln Val Leu Ser Ala 

            180                 185                 190         





His Val Ser Gly Arg Val Val Met Lys Ser Tyr Leu Ser Gly Met Pro 

        195                 200                 205             





Glu Cys Lys Phe Gly Met Asn Asp Lys Ile Val Ile Glu Lys Gln Gly 

    210                 215                 220                 





Lys Gly Thr Ala Asp Glu Thr Ser Lys Ser Gly Lys Gln Ser Ile Ala 

225                 230                 235                 240 





Ile Asp Asp Cys Thr Phe His Gln Cys Val Arg Leu Ser Lys Phe Asp 

                245                 250                 255     





Ser Glu Arg Ser Ile Ser Phe Ile Pro Pro Asp Gly Glu Phe Glu Leu 

            260                 265                 270         





Met Arg Tyr Arg Thr Thr Lys Asp Ile Ile Leu Pro Phe Arg Val Ile 

        275                 280                 285             





Pro Leu Val Arg Glu Val Gly Arg Thr Lys Leu Glu Val Lys Val Val 

    290                 295                 300                 





Ile Lys Ser Asn Phe Lys Pro Ser Leu Leu Ala Gln Lys Ile Glu Val 

305                 310                 315                 320 





Arg Ile Pro Thr Pro Leu Asn Thr Ser Gly Val Gln Val Ile Cys Met 

                325                 330                 335     





Lys Gly Lys Ala Lys Tyr Lys Ala Ser Glu Asn Ala Ile Val Trp Lys 

            340                 345                 350         





Ile Lys Arg Met Ala Gly Met Lys Glu Ser Gln Ile Ser Ala Glu Ile 

        355                 360                 365             





Glu Leu Leu Pro Thr Asn Asp Lys Lys Lys Trp Ala Arg Pro Pro Ile 

    370                 375                 380                 





Ser Met Asn Phe Glu Val Pro Phe Ala Pro Ser Gly Leu Lys Val Arg 

385                 390                 395                 400 





Tyr Leu Lys Val Phe Glu Pro Lys Leu Asn Tyr Ser Asp His Asp Val 

                405                 410                 415     





Ile Lys Trp Val Arg Tyr Ile Gly Arg Ser Gly Ile Tyr Glu Thr Arg 

            420                 425                 430         





Cys 

    





<210>  25

<211>  1958

<212>  DNA

<213>  Homo sapiens



<400>  25

ggcggcggca ctgcggtgaa agccgaggca gcgggcagac gagcaggggg cgggcggaca       60



tcttgggatc cggagagtgg ccgggccggc agagcagggg gccgaggaca ccaggtctgt      120



tctcagagcg atgggccgcg gagactgatc tgccgccatg attggaggct tattcatcta      180



taatcacaag ggggaggtgc tcatctcccg agtctaccga gatgacatcg ggaggaacgc      240



agtggatgcc tttcgggtca atgttatcca tgcccggcag caggtgcgca gccccgtcac      300



caacattgct cgcaccagct tcttccacgt taagcggtcc aacatttggc tggcagcagt      360



caccaagcag aatgtcaacg ctgccatggt cttcgaattc ctctataaga tgtgtgacgt      420



gatggctgcc tactttggca agatcagcga ggaaaacatc aagaacaatt ttgtgctcat      480



atatgagctg ctggatgaga ttctagactt tggctaccca cagaattccg agacaggcgc      540



gctgaaaacc ttcatcacgc agcagggcat caagagtcag catcagacaa aagaagagca      600



gtcacagatc accagccagg taactgggca gattggctgg cggcgagagg gtatcaagta      660



tcgtcggaat gagctcttcc tggatgtgct ggagagtgtg aacctgctca tgtccccaca      720



agggcaggtg ctgagtgccc atgtgtcggg ccgggtggtg atgaagagct acctgagtgg      780



catgcctgaa tgcaagtttg ggatgaatga caagattgtt attgaaaagc agggcaaagg      840



cacagctgat gaaacaagca agagcgggaa gcaatcaatt gccattgatg actgcacctt      900



ccaccagtgt gtgcgactca gcaagtttga ctctgaacgc agcatcagct ttatcccgcc      960



agatggagag tttgagctta tgaggtatcg cacaaccaag gacatcatcc ttcccttccg     1020



ggtgatcccg ctagtgcgag aagtgggacg caccaaactg gaggtcaagg tggtcatcaa     1080



gtccaacttt aaaccctcac tgctggctca gaagatcgag gtgaggatcc caaccccact     1140



gaacacaagc ggggtgcagg tgatctgcat gaaggggaag gccaagtaca aggccagcga     1200



gaatgccatc gtgtggaaga tcaagcgcat ggcaggcatg aaggaatcgc agatcagcgc     1260



agagattgag cttctgccta ccaacgacaa gaagaaatgg gctcgacccc ccatttccat     1320



gaactttgag gtgccattcg cgccctctgg cctcaaggtg cgctacttga aggtgtttga     1380



accgaagctg aactacagcg accatgatgt catcaaatgg gtgcgctaca ttggccgcag     1440



tggcatttat gaaactcgct gctagctgcc actaggcagc tagcccacct ccccagccac     1500



cctcctccac aggtccaggt gccgctccct cccccaccac acatcagtgt ctcctccctc     1560



ctgctttgct gccttccctt tgcaccagcc cgagtctagg tctgggccaa gcacattaca     1620



agtgggaccg gtggagcagc ccctgggctc cctgggcagg ggagttctga ggctcctgct     1680



ctcccatcca cctgtctgtc ctggcctaat gccaggctct gagttctgtg accaaagcca     1740



ggtgggttcc ctttccttcc cacccctgtg gccacagctc tggagtggga gggttggttg     1800



cccctcacct cagagctccc ccaaaggcca gtaatggatc cccggcctca gtccctactc     1860



tgctttggga tagtgtgagc ttcattttgt acacgtgtga cttcgtccag ttacaaaccc     1920



aataaactct gtagagtgga aaaaaaaaaa aaaaaaaa                             1958





<210>  26

<211>  435

<212>  PRT

<213>  Homo sapiens



<400>  26



Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 

1               5                   10                  15      





Ser Arg Val Tyr Arg Asp Asp Ile Gly Arg Asn Ala Val Asp Ala Phe 

            20                  25                  30          





Arg Val Asn Val Ile His Ala Arg Gln Gln Val Arg Ser Pro Val Thr 

        35                  40                  45              





Asn Ile Ala Arg Thr Ser Phe Phe His Val Lys Arg Ser Asn Ile Trp 

    50                  55                  60                  





Leu Ala Ala Val Thr Lys Gln Asn Val Asn Ala Ala Met Val Phe Glu 

65                  70                  75                  80  





Phe Leu Tyr Lys Met Cys Asp Val Met Ala Ala Tyr Phe Gly Lys Ile 

                85                  90                  95      





Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Leu Ile Tyr Glu Leu Leu 

            100                 105                 110         





Asp Glu Ile Leu Asp Phe Gly Tyr Pro Gln Asn Ser Glu Thr Gly Ala 

        115                 120                 125             





Leu Lys Thr Phe Ile Thr Gln Gln Gly Ile Lys Ser Gln His Gln Thr 

    130                 135                 140                 





Lys Glu Glu Gln Ser Gln Ile Thr Ser Gln Val Thr Gly Gln Ile Gly 

145                 150                 155                 160 





Trp Arg Arg Glu Gly Ile Lys Tyr Arg Arg Asn Glu Leu Phe Leu Asp 

                165                 170                 175     





Val Leu Glu Ser Val Asn Leu Leu Met Ser Pro Gln Gly Gln Val Leu 

            180                 185                 190         





Ser Ala His Val Ser Gly Arg Val Val Met Lys Ser Tyr Leu Ser Gly 

        195                 200                 205             





Met Pro Glu Cys Lys Phe Gly Met Asn Asp Lys Ile Val Ile Glu Lys 

    210                 215                 220                 





Gln Gly Lys Gly Thr Ala Asp Glu Thr Ser Lys Ser Gly Lys Gln Ser 

225                 230                 235                 240 





Ile Ala Ile Asp Asp Cys Thr Phe His Gln Cys Val Arg Leu Ser Lys 

                245                 250                 255     





Phe Asp Ser Glu Arg Ser Ile Ser Phe Ile Pro Pro Asp Gly Glu Phe 

            260                 265                 270         





Glu Leu Met Arg Tyr Arg Thr Thr Lys Asp Ile Ile Leu Pro Phe Arg 

        275                 280                 285             





Val Ile Pro Leu Val Arg Glu Val Gly Arg Thr Lys Leu Glu Val Lys 

    290                 295                 300                 





Val Val Ile Lys Ser Asn Phe Lys Pro Ser Leu Leu Ala Gln Lys Ile 

305                 310                 315                 320 





Glu Val Arg Ile Pro Thr Pro Leu Asn Thr Ser Gly Val Gln Val Ile 

                325                 330                 335     





Cys Met Lys Gly Lys Ala Lys Tyr Lys Ala Ser Glu Asn Ala Ile Val 

            340                 345                 350         





Trp Lys Ile Lys Arg Met Ala Gly Met Lys Glu Ser Gln Ile Ser Ala 

        355                 360                 365             





Glu Ile Glu Leu Leu Pro Thr Asn Asp Lys Lys Lys Trp Ala Arg Pro 

    370                 375                 380                 





Pro Ile Ser Met Asn Phe Glu Val Pro Phe Ala Pro Ser Gly Leu Lys 

385                 390                 395                 400 





Val Arg Tyr Leu Lys Val Phe Glu Pro Lys Leu Asn Tyr Ser Asp His 

                405                 410                 415     





Asp Val Ile Lys Trp Val Arg Tyr Ile Gly Arg Ser Gly Ile Tyr Glu 

            420                 425                 430         





Thr Arg Cys 

        435 





<210>  27

<211>  1986

<212>  DNA

<213>  Homo sapiens



<400>  27

ccttacccgg cgtgccccgc gcccggaggc gctgacgtgg ccgccgtcag agccgccatc       60



ttgtgggagc aaaaccaacg cctggctcgg agcagcagcc tctgaggtga gggcgagggg      120



cgcgggccgg tgtgggccgc agagacgttg gagccggcgg gggctgggga ctggcctcgg      180



ggcgacttga ggtgtccctg gccagtgtcc ttccacctgt ccacaagcat ggggaacatc      240



ttcgccaacc tcttcaaggg cctttttggc aaaaaagaaa tgcgcatcct catggtgggc      300



ctggatgctg cagggaagac cacgatcctc tacaagctta agctgggtga gatcgtgacc      360



accattccca ccataggctt caacgtggaa accgtggagt acaagaacat cagcttcact      420



gtgtgggacg tgggtggcca ggacaagatc cggcccctgt ggcgccacta cttccagaac      480



acacaaggcc tgatcttcgt ggtggacagc aatgacagag agcgtgtgaa cgaggcccgt      540



gaggagctca tgaggatgct ggccgaggac gagctccggg atgctgtcct cctggtgttc      600



gccaacaagc aggacctccc caacgccatg aatgcggccg agatcacaga caagctgggg      660



ctgcactcac tacgccacag gaactggtac attcaggcca cctgcgccac cagcggcgac      720



gggctctatg aaggactgga ctggctgtcc aatcagctcc ggaaccagaa gtgaacgcga      780



cccccctccc tctcactcct cttgccctct gctttactct catgtggcaa acgtgcggct      840



cgtggtgtga gtgccagaag ctgcctccgt ggtttggtca ccgtgtgcat cgcaccgtgc      900



tgtaaatgtg gcagacgcag cctgcggcca ggctttttat ttaatgtaaa tagtttttgt      960



ttccaatgag gcagtttctg gtactcctat gcaatattac tcagcttttt ttattgtaaa     1020



aagaaaaatc aactcactgt tcagtgctga gaggggatgt aggcccatgg gcacctggcc     1080



tccaggagtc gctgtgttgg gagagccggc cacgcccttg gctttagagc tgtgttgaaa     1140



tccattttgg tggttggttt ttaacccaaa ctcagtgcat tttttaaaat agttaagaat     1200



ccaagtcgag aacacttgaa cacacagaag ggagaccccg cctagcatag atttgcagtt     1260



acggcctgga tgccagtcgc cagcccagct gttcccctcg ggaacatgag gtggtggtgg     1320



cgcagcagac tgcgatcaat tctgcatggt cacagtagag atccccgcaa ctcgcttgtc     1380



cttgggtcac cctgcattcc atagccatgt gcttgtccct gtgctcccac ggttcccagg     1440



ggccaggctg ggagcccaca gccaccccac tatgccgcag gccgccctac ccaccttcag     1500



gcagcctatg ggacgcaggg ccccatctgt ccctcggtcg ccgtgtggcc agagtgggtc     1560



cgtcgtcccc aacactcgtg ctcgctcaga cactttggca ggatgtctgg ggcctcacca     1620



gcaggagcgc gtgcaagccg ggcaggcggt ccacctagac ccacagcccc tcgggagcac     1680



cccacctctg tgtgtgatgt agctttctct ccctcagcct gcaagggtcc gatttgccat     1740



cgaaaaagac aacctctact tttttctttt gtattttgat aaacactgaa gctggagctg     1800



ttaaatttat cttggggaaa cctcagaact ggtctatttg gtgtcgtgga acctcttact     1860



gctttcaata cacgattagt aatcaactgt tttgtatact tgttttcagt tttcatttcg     1920



acaaacaagc actgtaatta tagctattag aataaaatct cttaactatt tcaaaaaaaa     1980



aaaaaa                                                                1986





<210>  28

<211>  181

<212>  PRT

<213>  Homo sapiens



<400>  28



Met Gly Asn Ile Phe Ala Asn Leu Phe Lys Gly Leu Phe Gly Lys Lys 

1               5                   10                  15      





Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr 

            20                  25                  30          





Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr 

        35                  40                  45              





Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Ser Phe Thr 

    50                  55                  60                  





Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 

65                  70                  75                  80  





Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 

                85                  90                  95      





Arg Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala 

            100                 105                 110         





Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln 

        115                 120                 125             





Asp Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Thr Asp Lys Leu Gly 

    130                 135                 140                 





Leu His Ser Leu Arg His Arg Asn Trp Tyr Ile Gln Ala Thr Cys Ala 

145                 150                 155                 160 





Thr Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Gln 

                165                 170                 175     





Leu Arg Asn Gln Lys 

            180     





<210>  29

<211>  2020

<212>  DNA

<213>  Homo sapiens



<400>  29

gcccgcgcgt ggacggttgg gattagcggc cgcgggggcc ggtgggggtc gtggggcctc       60



ccccacccga gtacaggcga gcgagcggca tccgggcgga cccccgcctc ggggaccggg      120



aaactgaggc tcgggcggcc tgagacgccg tcaaggtcat gtaggtggtg ggggcttgca      180



tcttcgcctc ccgactccat ccagttcgtg tttgctgtga agacggtgtc cctggccagt      240



gtccttccac ctgtccacaa gcatggggaa catcttcgcc aacctcttca agggcctttt      300



tggcaaaaaa gaaatgcgca tcctcatggt gggcctggat gctgcaggga agaccacgat      360



cctctacaag cttaagctgg gtgagatcgt gaccaccatt cccaccatag gcttcaacgt      420



ggaaaccgtg gagtacaaga acatcagctt cactgtgtgg gacgtgggtg gccaggacaa      480



gatccggccc ctgtggcgcc actacttcca gaacacacaa ggcctgatct tcgtggtgga      540



cagcaatgac agagagcgtg tgaacgaggc ccgtgaggag ctcatgagga tgctggccga      600



ggacgagctc cgggatgctg tcctcctggt gttcgccaac aagcaggacc tccccaacgc      660



catgaatgcg gccgagatca cagacaagct ggggctgcac tcactacgcc acaggaactg      720



gtacattcag gccacctgcg ccaccagcgg cgacgggctc tatgaaggac tggactggct      780



gtccaatcag ctccggaacc agaagtgaac gcgacccccc tccctctcac tcctcttgcc      840



ctctgcttta ctctcatgtg gcaaacgtgc ggctcgtggt gtgagtgcca gaagctgcct      900



ccgtggtttg gtcaccgtgt gcatcgcacc gtgctgtaaa tgtggcagac gcagcctgcg      960



gccaggcttt ttatttaatg taaatagttt ttgtttccaa tgaggcagtt tctggtactc     1020



ctatgcaata ttactcagct ttttttattg taaaaagaaa aatcaactca ctgttcagtg     1080



ctgagagggg atgtaggccc atgggcacct ggcctccagg agtcgctgtg ttgggagagc     1140



cggccacgcc cttggcttta gagctgtgtt gaaatccatt ttggtggttg gtttttaacc     1200



caaactcagt gcatttttta aaatagttaa gaatccaagt cgagaacact tgaacacaca     1260



gaagggagac cccgcctagc atagatttgc agttacggcc tggatgccag tcgccagccc     1320



agctgttccc ctcgggaaca tgaggtggtg gtggcgcagc agactgcgat caattctgca     1380



tggtcacagt agagatcccc gcaactcgct tgtccttggg tcaccctgca ttccatagcc     1440



atgtgcttgt ccctgtgctc ccacggttcc caggggccag gctgggagcc cacagccacc     1500



ccactatgcc gcaggccgcc ctacccacct tcaggcagcc tatgggacgc agggccccat     1560



ctgtccctcg gtcgccgtgt ggccagagtg ggtccgtcgt ccccaacact cgtgctcgct     1620



cagacacttt ggcaggatgt ctggggcctc accagcagga gcgcgtgcaa gccgggcagg     1680



cggtccacct agacccacag cccctcggga gcaccccacc tctgtgtgtg atgtagcttt     1740



ctctccctca gcctgcaagg gtccgatttg ccatcgaaaa agacaacctc tacttttttc     1800



ttttgtattt tgataaacac tgaagctgga gctgttaaat ttatcttggg gaaacctcag     1860



aactggtcta tttggtgtcg tggaacctct tactgctttc aatacacgat tagtaatcaa     1920



ctgttttgta tacttgtttt cagttttcat ttcgacaaac aagcactgta attatagcta     1980



ttagaataaa atctcttaac tatttcaaaa aaaaaaaaaa                           2020





<210>  30

<211>  181

<212>  PRT

<213>  Homo sapiens



<400>  30



Met Gly Asn Ile Phe Ala Asn Leu Phe Lys Gly Leu Phe Gly Lys Lys 

1               5                   10                  15      





Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr 

            20                  25                  30          





Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr 

        35                  40                  45              





Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Ser Phe Thr 

    50                  55                  60                  





Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 

65                  70                  75                  80  





Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 

                85                  90                  95      





Arg Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala 

            100                 105                 110         





Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln 

        115                 120                 125             





Asp Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Thr Asp Lys Leu Gly 

    130                 135                 140                 





Leu His Ser Leu Arg His Arg Asn Trp Tyr Ile Gln Ala Thr Cys Ala 

145                 150                 155                 160 





Thr Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Gln 

                165                 170                 175     





Leu Arg Asn Gln Lys 

            180     





<210>  31

<211>  1998

<212>  DNA

<213>  Homo sapiens



<400>  31

gcccgcgcgt ggacggttgg gattagcggc cgcgggggcc ggtgggggtc gtggggcctc       60



ccccacccga gtacaggcga gcgagcggca tccgggcgga cccccgcctc ggggaccggg      120



aaactgaggc tcgggcggcc tgagacgccg tcaaggtcat gtaggtggtg ggggcttgca      180



tcttcgcctc ccgactccat ccagtgtccc tggccagtgt ccttccacct gtccacaagc      240



atggggaaca tcttcgccaa cctcttcaag ggcctttttg gcaaaaaaga aatgcgcatc      300



ctcatggtgg gcctggatgc tgcagggaag accacgatcc tctacaagct taagctgggt      360



gagatcgtga ccaccattcc caccataggc ttcaacgtgg aaaccgtgga gtacaagaac      420



atcagcttca ctgtgtggga cgtgggtggc caggacaaga tccggcccct gtggcgccac      480



tacttccaga acacacaagg cctgatcttc gtggtggaca gcaatgacag agagcgtgtg      540



aacgaggccc gtgaggagct catgaggatg ctggccgagg acgagctccg ggatgctgtc      600



ctcctggtgt tcgccaacaa gcaggacctc cccaacgcca tgaatgcggc cgagatcaca      660



gacaagctgg ggctgcactc actacgccac aggaactggt acattcaggc cacctgcgcc      720



accagcggcg acgggctcta tgaaggactg gactggctgt ccaatcagct ccggaaccag      780



aagtgaacgc gacccccctc cctctcactc ctcttgccct ctgctttact ctcatgtggc      840



aaacgtgcgg ctcgtggtgt gagtgccaga agctgcctcc gtggtttggt caccgtgtgc      900



atcgcaccgt gctgtaaatg tggcagacgc agcctgcggc caggcttttt atttaatgta      960



aatagttttt gtttccaatg aggcagtttc tggtactcct atgcaatatt actcagcttt     1020



ttttattgta aaaagaaaaa tcaactcact gttcagtgct gagaggggat gtaggcccat     1080



gggcacctgg cctccaggag tcgctgtgtt gggagagccg gccacgccct tggctttaga     1140



gctgtgttga aatccatttt ggtggttggt ttttaaccca aactcagtgc attttttaaa     1200



atagttaaga atccaagtcg agaacacttg aacacacaga agggagaccc cgcctagcat     1260



agatttgcag ttacggcctg gatgccagtc gccagcccag ctgttcccct cgggaacatg     1320



aggtggtggt ggcgcagcag actgcgatca attctgcatg gtcacagtag agatccccgc     1380



aactcgcttg tccttgggtc accctgcatt ccatagccat gtgcttgtcc ctgtgctccc     1440



acggttccca ggggccaggc tgggagccca cagccacccc actatgccgc aggccgccct     1500



acccaccttc aggcagccta tgggacgcag ggccccatct gtccctcggt cgccgtgtgg     1560



ccagagtggg tccgtcgtcc ccaacactcg tgctcgctca gacactttgg caggatgtct     1620



ggggcctcac cagcaggagc gcgtgcaagc cgggcaggcg gtccacctag acccacagcc     1680



cctcgggagc accccacctc tgtgtgtgat gtagctttct ctccctcagc ctgcaagggt     1740



ccgatttgcc atcgaaaaag acaacctcta cttttttctt ttgtattttg ataaacactg     1800



aagctggagc tgttaaattt atcttgggga aacctcagaa ctggtctatt tggtgtcgtg     1860



gaacctctta ctgctttcaa tacacgatta gtaatcaact gttttgtata cttgttttca     1920



gttttcattt cgacaaacaa gcactgtaat tatagctatt agaataaaat ctcttaacta     1980



tttcaaaaaa aaaaaaaa                                                   1998





<210>  32

<211>  181

<212>  PRT

<213>  Homo sapiens



<400>  32



Met Gly Asn Ile Phe Ala Asn Leu Phe Lys Gly Leu Phe Gly Lys Lys 

1               5                   10                  15      





Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr 

            20                  25                  30          





Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr 

        35                  40                  45              





Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Ser Phe Thr 

    50                  55                  60                  





Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 

65                  70                  75                  80  





Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 

                85                  90                  95      





Arg Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala 

            100                 105                 110         





Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln 

        115                 120                 125             





Asp Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Thr Asp Lys Leu Gly 

    130                 135                 140                 





Leu His Ser Leu Arg His Arg Asn Trp Tyr Ile Gln Ala Thr Cys Ala 

145                 150                 155                 160 





Thr Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Gln 

                165                 170                 175     





Leu Arg Asn Gln Lys 

            180     





<210>  33

<211>  1901

<212>  DNA

<213>  Homo sapiens



<400>  33

ccttacccgg cgtgccccgc gcccggaggc gctgacgtgg ccgccgtcag agccgccatc       60



ttgtgggagc aaaaccaacg cctggctcgg agcagcagcc tctgaggtgt ccctggccag      120



tgtccttcca cctgtccaca agcatgggga acatcttcgc caacctcttc aagggccttt      180



ttggcaaaaa agaaatgcgc atcctcatgg tgggcctgga tgctgcaggg aagaccacga      240



tcctctacaa gcttaagctg ggtgagatcg tgaccaccat tcccaccata ggcttcaacg      300



tggaaaccgt ggagtacaag aacatcagct tcactgtgtg ggacgtgggt ggccaggaca      360



agatccggcc cctgtggcgc cactacttcc agaacacaca aggcctgatc ttcgtggtgg      420



acagcaatga cagagagcgt gtgaacgagg cccgtgagga gctcatgagg atgctggccg      480



aggacgagct ccgggatgct gtcctcctgg tgttcgccaa caagcaggac ctccccaacg      540



ccatgaatgc ggccgagatc acagacaagc tggggctgca ctcactacgc cacaggaact      600



ggtacattca ggccacctgc gccaccagcg gcgacgggct ctatgaagga ctggactggc      660



tgtccaatca gctccggaac cagaagtgaa cgcgaccccc ctccctctca ctcctcttgc      720



cctctgcttt actctcatgt ggcaaacgtg cggctcgtgg tgtgagtgcc agaagctgcc      780



tccgtggttt ggtcaccgtg tgcatcgcac cgtgctgtaa atgtggcaga cgcagcctgc      840



ggccaggctt tttatttaat gtaaatagtt tttgtttcca atgaggcagt ttctggtact      900



cctatgcaat attactcagc tttttttatt gtaaaaagaa aaatcaactc actgttcagt      960



gctgagaggg gatgtaggcc catgggcacc tggcctccag gagtcgctgt gttgggagag     1020



ccggccacgc ccttggcttt agagctgtgt tgaaatccat tttggtggtt ggtttttaac     1080



ccaaactcag tgcatttttt aaaatagtta agaatccaag tcgagaacac ttgaacacac     1140



agaagggaga ccccgcctag catagatttg cagttacggc ctggatgcca gtcgccagcc     1200



cagctgttcc cctcgggaac atgaggtggt ggtggcgcag cagactgcga tcaattctgc     1260



atggtcacag tagagatccc cgcaactcgc ttgtccttgg gtcaccctgc attccatagc     1320



catgtgcttg tccctgtgct cccacggttc ccaggggcca ggctgggagc ccacagccac     1380



cccactatgc cgcaggccgc cctacccacc ttcaggcagc ctatgggacg cagggcccca     1440



tctgtccctc ggtcgccgtg tggccagagt gggtccgtcg tccccaacac tcgtgctcgc     1500



tcagacactt tggcaggatg tctggggcct caccagcagg agcgcgtgca agccgggcag     1560



gcggtccacc tagacccaca gcccctcggg agcaccccac ctctgtgtgt gatgtagctt     1620



tctctccctc agcctgcaag ggtccgattt gccatcgaaa aagacaacct ctactttttt     1680



cttttgtatt ttgataaaca ctgaagctgg agctgttaaa tttatcttgg ggaaacctca     1740



gaactggtct atttggtgtc gtggaacctc ttactgcttt caatacacga ttagtaatca     1800



actgttttgt atacttgttt tcagttttca tttcgacaaa caagcactgt aattatagct     1860



attagaataa aatctcttaa ctatttcaaa aaaaaaaaaa a                         1901





<210>  34

<211>  181

<212>  PRT

<213>  Homo sapiens



<400>  34



Met Gly Asn Ile Phe Ala Asn Leu Phe Lys Gly Leu Phe Gly Lys Lys 

1               5                   10                  15      





Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr 

            20                  25                  30          





Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr 

        35                  40                  45              





Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Ser Phe Thr 

    50                  55                  60                  





Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 

65                  70                  75                  80  





Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 

                85                  90                  95      





Arg Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala 

            100                 105                 110         





Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln 

        115                 120                 125             





Asp Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Thr Asp Lys Leu Gly 

    130                 135                 140                 





Leu His Ser Leu Arg His Arg Asn Trp Tyr Ile Gln Ala Thr Cys Ala 

145                 150                 155                 160 





Thr Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Gln 

                165                 170                 175     





Leu Arg Asn Gln Lys 

            180     





<210>  35

<211>  9501

<212>  DNA

<213>  Homo sapiens



<400>  35

ggccccaatg agtggcacac agtctactat caccgacagg tttcccctca aaaaacctat       60



aaggcatgga agtattttga accgagagtc accaacagat aagaagcaga aagttgagcg      120



cattgcatca catgattttg accccacaga tagctcctcc aagaagacaa agtctagttc      180



agaggagagt agatccgaga tatatggtct tgttcagcgt tgcgtaatca tccagaaaga      240



tgacaatgga tttgggctga cggtcagtgg agacaatcca gtcttcgtac agtctgtcaa      300



agaagatgga gcagccatgc gggctggagt acagacaggt gatcgaatca tcaaggtgaa      360



tggaactctg gtgactcatt caaatcatct ggaggtggtg aagctaatca aatctggttc      420



ctatgtagct ctcactgttc agggacgccc acctgggtcg ccccagattc cacttgccga      480



ctctgaagta gagccgtcag tcattggaca tatgtctccc atcatgacat ctcctcattc      540



acctggagca tctgggaata tggagagaat cactagtcct gtgctcatgg gggaggaaaa      600



caatgtggtt cataaccaga aagtagaaat tctgagaaaa atgttacaga aagaacagga      660



acggctacag ttattgcagg aagattacaa ccgaacacct gcccaaagat tgctaaaaga      720



gatccaagag gccaagaaac acattcctca gctgcaagag cagttatcca aagccacagg      780



ctctgctcag gatggagctg tagttacacc ctccagacct ttaggggaca ccctaacagt      840



cagtgaggca gaaacagatc ctggagatgt actgggcagg actgactgta gcagtggaga      900



tgcttctcgg cccagtagtg acaatgcaga tagtcccaag agtggcccaa aagagagaat      960



ttatctagag gaaaacccag agaaaagtga aacaattcag gacactgaca ctcaatcact     1020



tgtcggaagt ccctcaaccc gtatagcacc tcatattatt ggagcagaag atgatgattt     1080



tggtactgaa catgaacaga tcaatggaca gtgcagctgt ttccagagca ttgaattact     1140



aaaatctcgc ccggctcatt tggctgtttt cttacaccat gtagtttcac aatttgaccc     1200



tgcgactttg ctctgttatc tctattcaga cctgtataaa cataccaatt ccaaagaaac     1260



tcgtcgcatc ttccttgagt ttcatcagtt ctttctagat cgatcagcac acctgaaagt     1320



ttctgttcct gatgaaatgt ctgcagatct agaaaagaga agacctgagc tcattcctga     1380



ggatctgcat cgccactata tccaaactat gcaagaaaga gtccatccag aagttcaaag     1440



gcacttagaa gattttcggc agaaacgtag tatgggactg accttggctg aaagcgagct     1500



gactaaactt gatgcagagc gagacaagga ccgattgact ttggagaagg agcggacatg     1560



tgcagaacag attgttgcca aaattgaaga agtattgatg actgctcagg ctgtagagga     1620



agataagagc tccaccatgc agtatgttat tctcatgtat atgaagcatt tgggagtaaa     1680



agtgaaagag cctcgaaatt tggagcacaa acggggtcgg attggatttc ttcccaaaat     1740



caagcaaagt atgaagaaag ataaagaagg ggaagaaaaa gggaagcgaa gaggattccc     1800



cagcatcctg ggacccccac ggagaccaag ccgtcatgac aacagtgcaa ttggcagagc     1860



catggaacta cagaaggcgc gccaccctaa gcacttatcc acaccctcat ctgtgagtcc     1920



tgaacctcag gactctgcca agttgcgcca gagtgggtta gcaaatgaag gaacagacgc     1980



tggatacctg cctgccaatt ccatgtcttc tgtagcttca ggggcctctt tttcccagga     2040



aggagggaaa gagaatgata caggatcaaa gcaagttgga gaaacatcag cacctggaga     2100



caccttagat ggcacacctc gtactctcaa tactgtcttt gatttcccac cacctccatt     2160



agaccaagtg caggaggagg aatgtgaagt agaaagggtg actgaacatg ggacaccaaa     2220



gccctttcga aagtttgaca gtgtagcttt tggagaaagt caaagtgagg atgaacaatt     2280



tgaaaatgac ttagagacag acccacccaa ctggcagcag cttgttagtc gagaagtgtt     2340



actgggacta aaaccttgtg aaatcaaaag acaggaagtg attaatgaat tgttctacac     2400



tgaaagagct catgttcgaa cactgaaggt tcttgatcaa gtgttctatc agcgagtatc     2460



cagagaagga attctgtcac cctcagagct acggaaaatt ttttcaaact tggaagatat     2520



tcttcaactt catattggat tgaatgaaca aatgaaggct gttcgaaaga gaaatgagac     2580



ctctgttatc gatcagattg gggaagattt gctgacatgg ttcagcggac caggagagga     2640



gaaattgaaa catgctgctg ctaccttttg cagtaaccaa cctttcgccc tggaaatgat     2700



caaatctcgt cagaaaaagg attctcgatt tcagactttt gtgcaagatg ctgaaagtaa     2760



tccactgtgt cgtcgtcttc aactgaagga tattattccc actcaaatgc aaaggcttac     2820



taagtaccca cttctgttgg ataatattgc caaatacaca gaatggccaa cagaaaggga     2880



gaaggtgaag aaagctgcag atcactgtcg tcagatctta aattatgtaa atcaggctgt     2940



caaggaggca gaaaacaagc agcgcctaga agattatcag cgtcgccttg atacctccag     3000



cctgaagttg tcagagtacc caaatgttga agagctcagg aatttggatt taacaaaaag     3060



gaagatgatt catgaagggc cattggtttg gaaggtgaat agagataaaa ctattgattt     3120



atacacgttg ctgctggaag acattcttgt attgttacaa aagcaggatg atagactggt     3180



tttaaggtgt catagtaaga ttctggcatc tacagctgat agcaaacaca cgtttagccc     3240



tgtcattaag ttgagtacag tgttggttcg acaagtggca acagataaca aagctttatt     3300



cgtcatttcc atgtcagaca atggcgctca gatttatgaa ctggtggcac agacagtttc     3360



tgaaaagact gtctggcagg acctaatctg tcggatggct gcatcagtga aggagcaatc     3420



cacaaagcca attccattac cacagtcaac acctggcgaa ggagataatg atgaagaaga     3480



tccttcaaaa ttaaaagagg agcagcatgg catttcagtc actggtttgc agagtccaga     3540



cagagatttg ggattagaat ctaccttaat atcgtcaaaa cctcagtctc attcactgag     3600



tacctctggg aaatcagagg tacgtgatct gtttgtggct gagagacagt ttgcaaagga     3660



acaacataca gatgggacac taaaggaagt tggagaagat tatcaaatcg caatcccaga     3720



ttcacacctg cctgtctcag aagaacggtg ggcattggat gcactaagaa atttgggttt     3780



gttgaagcag ttgctggtgc aacagctagg tttgactgag aagagcgttc aggaagactg     3840



gcaacatttc ccaagataca gaacagcctc tcaggggccg cagacagaca gtgtcatcca     3900



gaactctgaa aatattaagg cctatcattc tggtgaagga catatgccct ttagaactgg     3960



aactggtgac attgcaactt gttacagtcc acggacttca actgaatctt ttgctccacg     4020



ggattcagtg ggactggcac cccaggatag ccaggcaagt aacattttag taatggacca     4080



catgattatg accccagaga tgcctaccat ggagccagaa gggggtcttg atgacagtgg     4140



agagcacttt tttgatgccc gtgaagcaca tagtgatgag aatccatcag aaggtgatgg     4200



agcagttaac aaggaagaga aggatgttaa tttacgcatc tcaggaaact atttgatcct     4260



tgatggctat gacccagtgc aggagagttc cacagatgag gaggttgctt cctcacttac     4320



cctgcagccc atgacaggca tccctgctgt ggaatccacc caccagcagc aacattctcc     4380



tcagaatact cactccgatg gggcaatttc accattcacc cccgaatttc tggtccagca     4440



gcgctgggga gctatggagt attcctgttt tgagatccag agtccctcct cttgtgcaga     4500



ttcacagagc cagatcatgg agtacattca taagatagag gctgaccttg aacacttaaa     4560



gaaggtggag gaaagttaca ccattctttg ccaaaggctg gctggatcag ccctcacaga     4620



caagcactca gataaaagtt agagccgcat gtcctggagg tgactgcagg ttgttggatt     4680



tggagtatcg gccgtgtctc accacatcct ggctccagtg tggatgcaga gagagtgtga     4740



cagaggatct gcctgtgaac cacctgggat tagtcaagtc ccaaggtgcc cagagtggga     4800



ctagttcttc acagtgtggc agctgcacta atctgtttgt gagggaatat ccattccctc     4860



actctactct cctcactatc ggaaattcat tttgattcag aataaaaacc aaatgtatag     4920



agctttgggt gtaggatatg aaattgtact tagatttaag aaaaagagaa aatcagatgt     4980



atttatttga cttcattccg tatttgaaag cacattttaa tttttatttg ccttgttttg     5040



ttttaattga gtagtgagag ttttagacct ttgtctttag tacacccaag gatcaactgc     5100



tcctgaagca aagaggtcag gatggagtat gcagaagttg ggtagagagg ttaagaagag     5160



gaggaagtga gacggggaag ggaggagcac cttgcttcac tatacagtat tccaagctct     5220



ctgctgtcca gtaggctgct tctctgaggg tcacctcaaa ggtatgctat gccgtgtggc     5280



tcttatgtgc ccaggtggtg tggtcagaga gtggatgggc ttcctcccgc cctgaggcaa     5340



gcacctcttc tctgtagctg ggatcaacca caattaatag gaatcctcaa catactaaat     5400



agcaggcact tgaaaatggg tgtgttttct tccattgtcg tcttttctat tgagggttgg     5460



gatttgggtg ggagaggaaa gcaaatttta ttttcttgac tataaatttg ttattcttgg     5520



tatcatttca tttttataat tatacattag acattggcac ttgtgtaaaa ctgtccctgc     5580



agattgagca ggaagtaaaa acaaatggaa atgcttcgga tagtggcagg ggtgggggtt     5640



gctaaggaaa gggtgggatg ggagtgggta aagagtttgg gaaggttatc taactgaatc     5700



actactgagt tgaatcatgg ctatcattag ccacaggtac tgctgattat aaggccagta     5760



aaattttagt acctggaggt ttgactctaa tttttgcact gatggtgcca aagggccctg     5820



agtcaaaagg atagccaagg gtggagtgga aaaagatatg gtgaaggcag aactgctcac     5880



accagctcca gaagcacgtc ctctgacttc actgccgcag ctctttccac acggggccgt     5940



gattgaccct aaaaattgca gaccagcaca tacactggac actgcaggca aggtgttggt     6000



aactgcctgc tctaggatga atagtagcgt tagcagcacc ctacagaggg taagtttcag     6060



aattgtaatt tgagaactcc ttcaattata ttgactttct ttggttttcc ttgtgcatta     6120



ggtatatatt ttttgaagta tttttgccaa ctaaaatgaa gtctgtaaat tctgttaata     6180



aacaaggagt tcatccgttg ctcacatctt tcattggtgc cctctgaact ctgtgggttg     6240



ctaggatgta attttaatgc ttccctgcag tccaaagatg attttttcac cacaaatggt     6300



aagggatgcc cacctacttt tataaacacc actgcaactt aacaagttta tttatctatg     6360



tccagatttc tgtttctgtc ctaaattgat ctgtgttttt aggtggatca acttggatct     6420



ttagacctca tctataaatt gaaattatat ttttagtcat aagccaagta caatctaact     6480



cagaatggga ttaaaaattt tagaagcaga agctaatata taaatgaagt ttgggatttg     6540



gaactttctg tatctcttag gaggaacaag taaaaaccaa atggttacat tgtgctgcta     6600



gaaataatgt cattctcaat taaaagggtt acacctgtag ccacttgaca ctaacaccat     6660



cgagggcaat taatcaggag aaaagtaaat ataaaaactt tgctcttaac gtcacacact     6720



acagggtaat tatgtaattc tctagcactc aattaagaag cttgtaggtt agcaaaattt     6780



cagtttctct agttcagcca gtgtcttgtc cttagtaatt atttgctttc cctgcagttc     6840



aatttctcct tggaactcta acaggactaa ctggaaaaat actttgacca tagctctagt     6900



acttccaaat aaattcatat ctagattttc aaacaaagcc ccaagatgaa gtctaattct     6960



gaaaatatct cacaattttt gaatgttctt tttatcttac cgacctaact tctcttttcc     7020



ctcccaactt ggcctcccac acgttccatt tcattttggc cattatagtc acatccgttt     7080



gactttggtt gtgacatctt cctttcagga tgatggaatt agatgcagtc tgtctttgag     7140



tgagactggt caccatcaga ggagtttttt ctaagtgacg tgactagaag ttgaaatcta     7200



cttccctgct aaagggcaca ggggtggtgt acaaagaaag ctaccttccc agagcaagca     7260



ggctgcattt tagctatgga agtgacctgc tgtgacactg tgctctcttc tgtgggctta     7320



atggttcctt tgctatgaag tggcaaatta catgtagagt gtctccttcc ttttcagaga     7380



acagttaatc aaggcaaatc agcaagcccc caaagtgctg taatttaaca tcatgattac     7440



caccttcgaa gctatatatt ttgcatactt taaaatcacc taacttggac tgcttgaatt     7500



acattggctt ttagaaccga aattgtaact atgtattgta tttcatggga ggtatatttt     7560



atgagctttt tggctttctt ttttcccaca gcaactgcca atgaaggatg aatccccttt     7620



ttaaaaagtt gttgttgttg ttgtttattt gattttgagt taggagggat aatagagaag     7680



tccatttaaa aattattttt agaagctaaa gaaagtaatt atgcttcctg tgaattgtct     7740



tttactggca tctttgtttt cctctttgat gttagtaaat ttggtgtaat acgtggggct     7800



tccatatttc aaagtggaag ctttcttctc tgaagtcgat atatggtttt gaattactag     7860



agctttggtc agtatttcct tccctatatg tcacagaggg caccactgag aactgcgtgc     7920



ataggacctc aaaatacaaa attagcaggg cctcacagtc agcttcctca tggctagttt     7980



ttccccctta tattacaatt tttgttttat aagtcatttt tttcctgata tttccaccac     8040



ttttcagagt catctacaaa atttttcttt cctcaagaaa agagttcctt ttgccttatt     8100



ccttatgcct tccccactgg tattgagggt tttgataata aattggtagg aaaaaaaagt     8160



acctcctaga aggaagcctt ccccaccatt tccaggtgcc aactgctaag cagatatatt     8220



ccaaaaatgg taactgtcat gtgcacactg ttggttattt ttaataagcc tcttcctact     8280



agaacatttt attttccttg ttcaccatac aatcatgtac tctttaacag aaattgcttt     8340



taaaaaatat ctggaactat ctttaaaaaa actttattaa taatcatgta tttttactga     8400



tcacattttg aaatgcctaa aagactttat tgttctaatt atccagatgt acctttgtaa     8460



aatagctctt ttatgaatta gctgataagg ctgtatgttt ctggaacaaa atattggtca     8520



tctaaaaact ttctgttttc tggggtctgg gaaaatagaa aataagattt caaatattaa     8580



ataagcttaa aggaaccaag catgtgactt ttactttgta ttctggttga tttgtcttgt     8640



ccaagttata ttagaaaagt tgaggagtcg aggagcctgt aattaatttt cctgtcagtg     8700



actgtcagac atcttcctgc ttattagagc atccctagca acaaggctaa accttcatga     8760



cagtgctggc aggtgggctt gccctagcat gtggggcagg tttgttgttt ttttaatagc     8820



tttattgaga tattcacata tcatataatt catccattta aagtgtataa tcagatgggt     8880



tttggtatat tattgatttt taattgtggt gaaatatata tataacaaaa tttgctattg     8940



taactatttt taagtataaa gttcagtgag gtaggccagc ttttatgacg cacctgaaga     9000



taactttggt tttaatccta ccctaaatga agcatatgcc tctatttttc ctgtccccag     9060



tgctgggctt cttcacatac caacatttct gtgcttttac caacagcatt ttagctcaga     9120



aggctcgctt actttgggca tttgctgtat tttggttttg aaatacttgt aatttgactt     9180



attcttggga taatatttta gttttcagtc attcaagggc acatttggct gacggagcta     9240



ataagcgtaa taaaatgctt agtagtttat accatctttt agttaaacat tttaaagatt     9300



aagactattc aaatgtactt tgcggaaatt aacctgtttg tatgcctggc tttgtttaca     9360



aacatatatc tatatctata tatatagata cagatacaga tacatatctg gtggaacaaa     9420



gaaatacctg taccattccc acttgctctt tgatagccac ctcctaggaa tggagacaat     9480



aaaactctgt atttgcatgt g                                               9501





<210>  36

<211>  1544

<212>  PRT

<213>  Homo sapiens



<400>  36



Met Ser Gly Thr Gln Ser Thr Ile Thr Asp Arg Phe Pro Leu Lys Lys 

1               5                   10                  15      





Pro Ile Arg His Gly Ser Ile Leu Asn Arg Glu Ser Pro Thr Asp Lys 

            20                  25                  30          





Lys Gln Lys Val Glu Arg Ile Ala Ser His Asp Phe Asp Pro Thr Asp 

        35                  40                  45              





Ser Ser Ser Lys Lys Thr Lys Ser Ser Ser Glu Glu Ser Arg Ser Glu 

    50                  55                  60                  





Ile Tyr Gly Leu Val Gln Arg Cys Val Ile Ile Gln Lys Asp Asp Asn 

65                  70                  75                  80  





Gly Phe Gly Leu Thr Val Ser Gly Asp Asn Pro Val Phe Val Gln Ser 

                85                  90                  95      





Val Lys Glu Asp Gly Ala Ala Met Arg Ala Gly Val Gln Thr Gly Asp 

            100                 105                 110         





Arg Ile Ile Lys Val Asn Gly Thr Leu Val Thr His Ser Asn His Leu 

        115                 120                 125             





Glu Val Val Lys Leu Ile Lys Ser Gly Ser Tyr Val Ala Leu Thr Val 

    130                 135                 140                 





Gln Gly Arg Pro Pro Gly Ser Pro Gln Ile Pro Leu Ala Asp Ser Glu 

145                 150                 155                 160 





Val Glu Pro Ser Val Ile Gly His Met Ser Pro Ile Met Thr Ser Pro 

                165                 170                 175     





His Ser Pro Gly Ala Ser Gly Asn Met Glu Arg Ile Thr Ser Pro Val 

            180                 185                 190         





Leu Met Gly Glu Glu Asn Asn Val Val His Asn Gln Lys Val Glu Ile 

        195                 200                 205             





Leu Arg Lys Met Leu Gln Lys Glu Gln Glu Arg Leu Gln Leu Leu Gln 

    210                 215                 220                 





Glu Asp Tyr Asn Arg Thr Pro Ala Gln Arg Leu Leu Lys Glu Ile Gln 

225                 230                 235                 240 





Glu Ala Lys Lys His Ile Pro Gln Leu Gln Glu Gln Leu Ser Lys Ala 

                245                 250                 255     





Thr Gly Ser Ala Gln Asp Gly Ala Val Val Thr Pro Ser Arg Pro Leu 

            260                 265                 270         





Gly Asp Thr Leu Thr Val Ser Glu Ala Glu Thr Asp Pro Gly Asp Val 

        275                 280                 285             





Leu Gly Arg Thr Asp Cys Ser Ser Gly Asp Ala Ser Arg Pro Ser Ser 

    290                 295                 300                 





Asp Asn Ala Asp Ser Pro Lys Ser Gly Pro Lys Glu Arg Ile Tyr Leu 

305                 310                 315                 320 





Glu Glu Asn Pro Glu Lys Ser Glu Thr Ile Gln Asp Thr Asp Thr Gln 

                325                 330                 335     





Ser Leu Val Gly Ser Pro Ser Thr Arg Ile Ala Pro His Ile Ile Gly 

            340                 345                 350         





Ala Glu Asp Asp Asp Phe Gly Thr Glu His Glu Gln Ile Asn Gly Gln 

        355                 360                 365             





Cys Ser Cys Phe Gln Ser Ile Glu Leu Leu Lys Ser Arg Pro Ala His 

    370                 375                 380                 





Leu Ala Val Phe Leu His His Val Val Ser Gln Phe Asp Pro Ala Thr 

385                 390                 395                 400 





Leu Leu Cys Tyr Leu Tyr Ser Asp Leu Tyr Lys His Thr Asn Ser Lys 

                405                 410                 415     





Glu Thr Arg Arg Ile Phe Leu Glu Phe His Gln Phe Phe Leu Asp Arg 

            420                 425                 430         





Ser Ala His Leu Lys Val Ser Val Pro Asp Glu Met Ser Ala Asp Leu 

        435                 440                 445             





Glu Lys Arg Arg Pro Glu Leu Ile Pro Glu Asp Leu His Arg His Tyr 

    450                 455                 460                 





Ile Gln Thr Met Gln Glu Arg Val His Pro Glu Val Gln Arg His Leu 

465                 470                 475                 480 





Glu Asp Phe Arg Gln Lys Arg Ser Met Gly Leu Thr Leu Ala Glu Ser 

                485                 490                 495     





Glu Leu Thr Lys Leu Asp Ala Glu Arg Asp Lys Asp Arg Leu Thr Leu 

            500                 505                 510         





Glu Lys Glu Arg Thr Cys Ala Glu Gln Ile Val Ala Lys Ile Glu Glu 

        515                 520                 525             





Val Leu Met Thr Ala Gln Ala Val Glu Glu Asp Lys Ser Ser Thr Met 

    530                 535                 540                 





Gln Tyr Val Ile Leu Met Tyr Met Lys His Leu Gly Val Lys Val Lys 

545                 550                 555                 560 





Glu Pro Arg Asn Leu Glu His Lys Arg Gly Arg Ile Gly Phe Leu Pro 

                565                 570                 575     





Lys Ile Lys Gln Ser Met Lys Lys Asp Lys Glu Gly Glu Glu Lys Gly 

            580                 585                 590         





Lys Arg Arg Gly Phe Pro Ser Ile Leu Gly Pro Pro Arg Arg Pro Ser 

        595                 600                 605             





Arg His Asp Asn Ser Ala Ile Gly Arg Ala Met Glu Leu Gln Lys Ala 

    610                 615                 620                 





Arg His Pro Lys His Leu Ser Thr Pro Ser Ser Val Ser Pro Glu Pro 

625                 630                 635                 640 





Gln Asp Ser Ala Lys Leu Arg Gln Ser Gly Leu Ala Asn Glu Gly Thr 

                645                 650                 655     





Asp Ala Gly Tyr Leu Pro Ala Asn Ser Met Ser Ser Val Ala Ser Gly 

            660                 665                 670         





Ala Ser Phe Ser Gln Glu Gly Gly Lys Glu Asn Asp Thr Gly Ser Lys 

        675                 680                 685             





Gln Val Gly Glu Thr Ser Ala Pro Gly Asp Thr Leu Asp Gly Thr Pro 

    690                 695                 700                 





Arg Thr Leu Asn Thr Val Phe Asp Phe Pro Pro Pro Pro Leu Asp Gln 

705                 710                 715                 720 





Val Gln Glu Glu Glu Cys Glu Val Glu Arg Val Thr Glu His Gly Thr 

                725                 730                 735     





Pro Lys Pro Phe Arg Lys Phe Asp Ser Val Ala Phe Gly Glu Ser Gln 

            740                 745                 750         





Ser Glu Asp Glu Gln Phe Glu Asn Asp Leu Glu Thr Asp Pro Pro Asn 

        755                 760                 765             





Trp Gln Gln Leu Val Ser Arg Glu Val Leu Leu Gly Leu Lys Pro Cys 

    770                 775                 780                 





Glu Ile Lys Arg Gln Glu Val Ile Asn Glu Leu Phe Tyr Thr Glu Arg 

785                 790                 795                 800 





Ala His Val Arg Thr Leu Lys Val Leu Asp Gln Val Phe Tyr Gln Arg 

                805                 810                 815     





Val Ser Arg Glu Gly Ile Leu Ser Pro Ser Glu Leu Arg Lys Ile Phe 

            820                 825                 830         





Ser Asn Leu Glu Asp Ile Leu Gln Leu His Ile Gly Leu Asn Glu Gln 

        835                 840                 845             





Met Lys Ala Val Arg Lys Arg Asn Glu Thr Ser Val Ile Asp Gln Ile 

    850                 855                 860                 





Gly Glu Asp Leu Leu Thr Trp Phe Ser Gly Pro Gly Glu Glu Lys Leu 

865                 870                 875                 880 





Lys His Ala Ala Ala Thr Phe Cys Ser Asn Gln Pro Phe Ala Leu Glu 

                885                 890                 895     





Met Ile Lys Ser Arg Gln Lys Lys Asp Ser Arg Phe Gln Thr Phe Val 

            900                 905                 910         





Gln Asp Ala Glu Ser Asn Pro Leu Cys Arg Arg Leu Gln Leu Lys Asp 

        915                 920                 925             





Ile Ile Pro Thr Gln Met Gln Arg Leu Thr Lys Tyr Pro Leu Leu Leu 

    930                 935                 940                 





Asp Asn Ile Ala Lys Tyr Thr Glu Trp Pro Thr Glu Arg Glu Lys Val 

945                 950                 955                 960 





Lys Lys Ala Ala Asp His Cys Arg Gln Ile Leu Asn Tyr Val Asn Gln 

                965                 970                 975     





Ala Val Lys Glu Ala Glu Asn Lys Gln Arg Leu Glu Asp Tyr Gln Arg 

            980                 985                 990         





Arg Leu Asp Thr Ser Ser Leu Lys  Leu Ser Glu Tyr Pro  Asn Val Glu 

        995                 1000                 1005             





Glu Leu  Arg Asn Leu Asp Leu  Thr Lys Arg Lys Met  Ile His Glu 

    1010                 1015                 1020             





Gly Pro  Leu Val Trp Lys Val  Asn Arg Asp Lys Thr  Ile Asp Leu 

    1025                 1030                 1035             





Tyr Thr  Leu Leu Leu Glu Asp  Ile Leu Val Leu Leu  Gln Lys Gln 

    1040                 1045                 1050             





Asp Asp  Arg Leu Val Leu Arg  Cys His Ser Lys Ile  Leu Ala Ser 

    1055                 1060                 1065             





Thr Ala  Asp Ser Lys His Thr  Phe Ser Pro Val Ile  Lys Leu Ser 

    1070                 1075                 1080             





Thr Val  Leu Val Arg Gln Val  Ala Thr Asp Asn Lys  Ala Leu Phe 

    1085                 1090                 1095             





Val Ile  Ser Met Ser Asp Asn  Gly Ala Gln Ile Tyr  Glu Leu Val 

    1100                 1105                 1110             





Ala Gln  Thr Val Ser Glu Lys  Thr Val Trp Gln Asp  Leu Ile Cys 

    1115                 1120                 1125             





Arg Met  Ala Ala Ser Val Lys  Glu Gln Ser Thr Lys  Pro Ile Pro 

    1130                 1135                 1140             





Leu Pro  Gln Ser Thr Pro Gly  Glu Gly Asp Asn Asp  Glu Glu Asp 

    1145                 1150                 1155             





Pro Ser  Lys Leu Lys Glu Glu  Gln His Gly Ile Ser  Val Thr Gly 

    1160                 1165                 1170             





Leu Gln  Ser Pro Asp Arg Asp  Leu Gly Leu Glu Ser  Thr Leu Ile 

    1175                 1180                 1185             





Ser Ser  Lys Pro Gln Ser His  Ser Leu Ser Thr Ser  Gly Lys Ser 

    1190                 1195                 1200             





Glu Val  Arg Asp Leu Phe Val  Ala Glu Arg Gln Phe  Ala Lys Glu 

    1205                 1210                 1215             





Gln His  Thr Asp Gly Thr Leu  Lys Glu Val Gly Glu  Asp Tyr Gln 

    1220                 1225                 1230             





Ile Ala  Ile Pro Asp Ser His  Leu Pro Val Ser Glu  Glu Arg Trp 

    1235                 1240                 1245             





Ala Leu  Asp Ala Leu Arg Asn  Leu Gly Leu Leu Lys  Gln Leu Leu 

    1250                 1255                 1260             





Val Gln  Gln Leu Gly Leu Thr  Glu Lys Ser Val Gln  Glu Asp Trp 

    1265                 1270                 1275             





Gln His  Phe Pro Arg Tyr Arg  Thr Ala Ser Gln Gly  Pro Gln Thr 

    1280                 1285                 1290             





Asp Ser  Val Ile Gln Asn Ser  Glu Asn Ile Lys Ala  Tyr His Ser 

    1295                 1300                 1305             





Gly Glu  Gly His Met Pro Phe  Arg Thr Gly Thr Gly  Asp Ile Ala 

    1310                 1315                 1320             





Thr Cys  Tyr Ser Pro Arg Thr  Ser Thr Glu Ser Phe  Ala Pro Arg 

    1325                 1330                 1335             





Asp Ser  Val Gly Leu Ala Pro  Gln Asp Ser Gln Ala  Ser Asn Ile 

    1340                 1345                 1350             





Leu Val  Met Asp His Met Ile  Met Thr Pro Glu Met  Pro Thr Met 

    1355                 1360                 1365             





Glu Pro  Glu Gly Gly Leu Asp  Asp Ser Gly Glu His  Phe Phe Asp 

    1370                 1375                 1380             





Ala Arg  Glu Ala His Ser Asp  Glu Asn Pro Ser Glu  Gly Asp Gly 

    1385                 1390                 1395             





Ala Val  Asn Lys Glu Glu Lys  Asp Val Asn Leu Arg  Ile Ser Gly 

    1400                 1405                 1410             





Asn Tyr  Leu Ile Leu Asp Gly  Tyr Asp Pro Val Gln  Glu Ser Ser 

    1415                 1420                 1425             





Thr Asp  Glu Glu Val Ala Ser  Ser Leu Thr Leu Gln  Pro Met Thr 

    1430                 1435                 1440             





Gly Ile  Pro Ala Val Glu Ser  Thr His Gln Gln Gln  His Ser Pro 

    1445                 1450                 1455             





Gln Asn  Thr His Ser Asp Gly  Ala Ile Ser Pro Phe  Thr Pro Glu 

    1460                 1465                 1470             





Phe Leu  Val Gln Gln Arg Trp  Gly Ala Met Glu Tyr  Ser Cys Phe 

    1475                 1480                 1485             





Glu Ile  Gln Ser Pro Ser Ser  Cys Ala Asp Ser Gln  Ser Gln Ile 

    1490                 1495                 1500             





Met Glu  Tyr Ile His Lys Ile  Glu Ala Asp Leu Glu  His Leu Lys 

    1505                 1510                 1515             





Lys Val  Glu Glu Ser Tyr Thr  Ile Leu Cys Gln Arg  Leu Ala Gly 

    1520                 1525                 1530             





Ser Ala  Leu Thr Asp Lys His  Ser Asp Lys Ser 

    1535                 1540                 





<210>  37

<211>  3044

<212>  DNA

<213>  Homo sapiens



<400>  37

ctgacatgct gacatcgccc cctgaggact tggctgcaac cccagagccc ccagggtgtc       60



ccggagccct ggaccgtgct ggcagctgga cggagctccc tggctgaggg ccaggtgggt      120



ggcagagcaa aagaggaatg gactgtgggc cacctgctac cctccagccc cacctgactg      180



ggccacctgg cactgcccac caccctgtag cagtgtgcca gcaggagagt ctgtcctttg      240



cagagctgcc cgccctgaag cccccgagcc cagtgtgtct ggaccttttc cctgttgccc      300



cagaggagct tcgggctcct ggcagccgct ggtccctggg gacccctgcc cctctccaag      360



ggttgctatg gccattatcc ccaggaggct cagatacaga gatcaccagc ggggggatgc      420



ggcccagcag ggctggcagc tggccacact gtcctggtgc ccagccccca gctctggagg      480



gaccctggag tccccgacac acacagccac agcgccgggc cagccacggc tcggagaaga      540



agtctgcctg gcgcaagatg cgggtgtacc agcgtgaaga ggtccccggc tgccccgagg      600



cccacgctgt cttcctagag cctggccagg tagtgcaaga gcaggccctg agcacagagg      660



agcccagggt ggagttgtct gggtccaccc gagtgagcct cgaaggtcct gagcggaggc      720



gcttctcggc atcggagctg atgacccggc tgcactcttc tctgcgcctg gggcggaatt      780



cagcagcccg ggcactcatc tctgggtcag gcaccggagc agcccgggaa gggaaagcat      840



ctggaatgga ggctcgaagt gtagagatga gcggggaccg ggtgtcgcgg ccagcccctg      900



gtgactcacg agagggcgat tggtccgagc ccaggctaga cacacaggaa gagccgcctt      960



tggggtccag gagcaccaac gagcggcgcc agtctcgatt cctccttaac tccgtcctct     1020



atcaggaata cagcgacgtg gccagcgccc gcgaactgcg gcggcagcag cgcgaggagg     1080



agggcccggg ggacgaggcc gagggcgcag aggaggggcc ggggccgccg cgggccaacc     1140



tctcccccag cagctccttc cgggcgcagc gctcggcgcg aggctccacc ttctcgctgt     1200



ggcaggatat ccccgacgta cgcggcagcg gcgtcctggc cacgctgagc ctgcgggact     1260



gcaagctgca ggaggccaag tttgagctga tcacctccga ggcctcctac atccacagcc     1320



tgtcggtggc tgtgggccac ttcttaggct ctgccgagct gagcgagtgt ctgggggcgc     1380



aggacaagca gtggctgttt tccaaactgc ccgaggtcaa gagcaccagc gagaggttcc     1440



tgcaggacct ggagcagcgg ctggaggcag atgtgctgcg cttcagcgtg tgcgacgtgg     1500



tgctggacca ctgcccggcc ttccgcagag tctacctgcc ctatgtcacc aaccaggcct     1560



accaggagcg cacctaccag cgcctgctcc tggagaaccc caggttccct ggcatcctgg     1620



ctcgcctgga ggagtctcct gtgtgccagc gtctgcccct tacctccttc cttatcctgc     1680



ccttccagag gatcacccgc ctcaagatgt tggtggagaa catcctgaag cggacagcac     1740



agggctctga agacgaagac atggccacca aggccttcaa tgcgctcaag gagctggtgc     1800



aggagtgcaa tgctagtgta cagtccatga agaggacaga ggaactcatc cacctgagca     1860



agaagatcca ctttgagggc aagattttcc cgctgatctc tcaggcccgc tggctggttc     1920



ggcatggaga gttggtagag ctggcaccac tgcctgcagc accccctgcc aagctgaagc     1980



tgtccagcaa ggcagtctac ctccacctct tcaatgactg cttgctgctc tctcggcgga     2040



aggagctagg gaagtttgcc gttttcgtcc atgccaagat ggctgagctg caggtgcggg     2100



acctgagcct gaagctgcag ggcatccccg gccacgtgtt cctcctccag ctcctccacg     2160



ggcagcacat gaagcaccag ttcctgctgc gggcccggac ggaaagtgag aagcagcgat     2220



ggatctcagc cttgtgcccc tccagccccc aggaggacaa ggaggtcatc agtgaggggg     2280



aagattgccc ccaggttcag tgtgttagga catacaaggc actgcaccca gatgagctga     2340



ccttggagaa gactgacatc ctgtcagtga ggacctggac cagtgacggc tggctggaag     2400



gggtccgcct ggcagatggt gagaaggggt gggtgcccca ggcctatgtg gaagagatca     2460



gcagcctcag cgcccgcctc cgaaacctcc gggagaataa gcgagtcaca agtgccacca     2520



gcaaactggg ggaggctcct gtgtgatggg cagccatggc ctaggacccc acctccatgc     2580



ctggctcctg gatggtcctg gaggggcctg cagtgtctcc attccccaag ctgctcctgc     2640



tggcacttcg cttctgtggc cttggcattg agggcacagg ctggacacag gaatgggggc     2700



gcctccagag ggtctctccg tcctcatgct cctcagtgtc cacacttcaa ggccaaggat     2760



agtttcttcc tctgacatgg ggaccataac aggtgatcac tgatacctgg caaagactgg     2820



ggccctctcc tttctatgtc ctcaatcctg cctgactctt ggtccttctg gcagggacct     2880



ggctggggaa cgttctggtg ctgatggtgc tgggacctat atgtatattt atatatatct     2940



ggggtcttgt ctaccacctc ccctggtcag agcctgagtg ggtgctggtt gctgtgtctt     3000



gtctgtaaat aaactcctat catgcctttt aaaaaaaaaa aaaa                      3044





<210>  38

<211>  802

<212>  PRT

<213>  Homo sapiens



<400>  38



Met Asp Cys Gly Pro Pro Ala Thr Leu Gln Pro His Leu Thr Gly Pro 

1               5                   10                  15      





Pro Gly Thr Ala His His Pro Val Ala Val Cys Gln Gln Glu Ser Leu 

            20                  25                  30          





Ser Phe Ala Glu Leu Pro Ala Leu Lys Pro Pro Ser Pro Val Cys Leu 

        35                  40                  45              





Asp Leu Phe Pro Val Ala Pro Glu Glu Leu Arg Ala Pro Gly Ser Arg 

    50                  55                  60                  





Trp Ser Leu Gly Thr Pro Ala Pro Leu Gln Gly Leu Leu Trp Pro Leu 

65                  70                  75                  80  





Ser Pro Gly Gly Ser Asp Thr Glu Ile Thr Ser Gly Gly Met Arg Pro 

                85                  90                  95      





Ser Arg Ala Gly Ser Trp Pro His Cys Pro Gly Ala Gln Pro Pro Ala 

            100                 105                 110         





Leu Glu Gly Pro Trp Ser Pro Arg His Thr Gln Pro Gln Arg Arg Ala 

        115                 120                 125             





Ser His Gly Ser Glu Lys Lys Ser Ala Trp Arg Lys Met Arg Val Tyr 

    130                 135                 140                 





Gln Arg Glu Glu Val Pro Gly Cys Pro Glu Ala His Ala Val Phe Leu 

145                 150                 155                 160 





Glu Pro Gly Gln Val Val Gln Glu Gln Ala Leu Ser Thr Glu Glu Pro 

                165                 170                 175     





Arg Val Glu Leu Ser Gly Ser Thr Arg Val Ser Leu Glu Gly Pro Glu 

            180                 185                 190         





Arg Arg Arg Phe Ser Ala Ser Glu Leu Met Thr Arg Leu His Ser Ser 

        195                 200                 205             





Leu Arg Leu Gly Arg Asn Ser Ala Ala Arg Ala Leu Ile Ser Gly Ser 

    210                 215                 220                 





Gly Thr Gly Ala Ala Arg Glu Gly Lys Ala Ser Gly Met Glu Ala Arg 

225                 230                 235                 240 





Ser Val Glu Met Ser Gly Asp Arg Val Ser Arg Pro Ala Pro Gly Asp 

                245                 250                 255     





Ser Arg Glu Gly Asp Trp Ser Glu Pro Arg Leu Asp Thr Gln Glu Glu 

            260                 265                 270         





Pro Pro Leu Gly Ser Arg Ser Thr Asn Glu Arg Arg Gln Ser Arg Phe 

        275                 280                 285             





Leu Leu Asn Ser Val Leu Tyr Gln Glu Tyr Ser Asp Val Ala Ser Ala 

    290                 295                 300                 





Arg Glu Leu Arg Arg Gln Gln Arg Glu Glu Glu Gly Pro Gly Asp Glu 

305                 310                 315                 320 





Ala Glu Gly Ala Glu Glu Gly Pro Gly Pro Pro Arg Ala Asn Leu Ser 

                325                 330                 335     





Pro Ser Ser Ser Phe Arg Ala Gln Arg Ser Ala Arg Gly Ser Thr Phe 

            340                 345                 350         





Ser Leu Trp Gln Asp Ile Pro Asp Val Arg Gly Ser Gly Val Leu Ala 

        355                 360                 365             





Thr Leu Ser Leu Arg Asp Cys Lys Leu Gln Glu Ala Lys Phe Glu Leu 

    370                 375                 380                 





Ile Thr Ser Glu Ala Ser Tyr Ile His Ser Leu Ser Val Ala Val Gly 

385                 390                 395                 400 





His Phe Leu Gly Ser Ala Glu Leu Ser Glu Cys Leu Gly Ala Gln Asp 

                405                 410                 415     





Lys Gln Trp Leu Phe Ser Lys Leu Pro Glu Val Lys Ser Thr Ser Glu 

            420                 425                 430         





Arg Phe Leu Gln Asp Leu Glu Gln Arg Leu Glu Ala Asp Val Leu Arg 

        435                 440                 445             





Phe Ser Val Cys Asp Val Val Leu Asp His Cys Pro Ala Phe Arg Arg 

    450                 455                 460                 





Val Tyr Leu Pro Tyr Val Thr Asn Gln Ala Tyr Gln Glu Arg Thr Tyr 

465                 470                 475                 480 





Gln Arg Leu Leu Leu Glu Asn Pro Arg Phe Pro Gly Ile Leu Ala Arg 

                485                 490                 495     





Leu Glu Glu Ser Pro Val Cys Gln Arg Leu Pro Leu Thr Ser Phe Leu 

            500                 505                 510         





Ile Leu Pro Phe Gln Arg Ile Thr Arg Leu Lys Met Leu Val Glu Asn 

        515                 520                 525             





Ile Leu Lys Arg Thr Ala Gln Gly Ser Glu Asp Glu Asp Met Ala Thr 

    530                 535                 540                 





Lys Ala Phe Asn Ala Leu Lys Glu Leu Val Gln Glu Cys Asn Ala Ser 

545                 550                 555                 560 





Val Gln Ser Met Lys Arg Thr Glu Glu Leu Ile His Leu Ser Lys Lys 

                565                 570                 575     





Ile His Phe Glu Gly Lys Ile Phe Pro Leu Ile Ser Gln Ala Arg Trp 

            580                 585                 590         





Leu Val Arg His Gly Glu Leu Val Glu Leu Ala Pro Leu Pro Ala Ala 

        595                 600                 605             





Pro Pro Ala Lys Leu Lys Leu Ser Ser Lys Ala Val Tyr Leu His Leu 

    610                 615                 620                 





Phe Asn Asp Cys Leu Leu Leu Ser Arg Arg Lys Glu Leu Gly Lys Phe 

625                 630                 635                 640 





Ala Val Phe Val His Ala Lys Met Ala Glu Leu Gln Val Arg Asp Leu 

                645                 650                 655     





Ser Leu Lys Leu Gln Gly Ile Pro Gly His Val Phe Leu Leu Gln Leu 

            660                 665                 670         





Leu His Gly Gln His Met Lys His Gln Phe Leu Leu Arg Ala Arg Thr 

        675                 680                 685             





Glu Ser Glu Lys Gln Arg Trp Ile Ser Ala Leu Cys Pro Ser Ser Pro 

    690                 695                 700                 





Gln Glu Asp Lys Glu Val Ile Ser Glu Gly Glu Asp Cys Pro Gln Val 

705                 710                 715                 720 





Gln Cys Val Arg Thr Tyr Lys Ala Leu His Pro Asp Glu Leu Thr Leu 

                725                 730                 735     





Glu Lys Thr Asp Ile Leu Ser Val Arg Thr Trp Thr Ser Asp Gly Trp 

            740                 745                 750         





Leu Glu Gly Val Arg Leu Ala Asp Gly Glu Lys Gly Trp Val Pro Gln 

        755                 760                 765             





Ala Tyr Val Glu Glu Ile Ser Ser Leu Ser Ala Arg Leu Arg Asn Leu 

    770                 775                 780                 





Arg Glu Asn Lys Arg Val Thr Ser Ala Thr Ser Lys Leu Gly Glu Ala 

785                 790                 795                 800 





Pro Val 

        





<210>  39

<211>  1619

<212>  DNA

<213>  Homo sapiens



<400>  39

tcagccgctc cctctgggct tccgtcctcc gcccgcgccc gacggagcct gttcgcgtcg       60



actgcccaga gtccgcgaat cctccgctcc gagcccgtcc ggactccccc gatcccagct      120



ttctctcctt tgaaaacact aagaataatg tcactgcatc agtttttact agagccaatc      180



acctgtcatg cctggaacag ggatcgtact cagattgccc tcagtcccaa taatcacgaa      240



gtgcacatct ataagaagaa cgggagccag tgggtgaaag ctcatgaact caaggagcac      300



aacggacaca tcacaggtat tgactgggct cccaagagcg accgcattgt cacttgtggg      360



gcagaccgca atgcctatgt ctggagtcag aaagatggtg tttggaagcc aaccctggtg      420



atcctgagaa ttaatcgcgc agctactttt gtgaagtggt cccccctaga gaacaaattt      480



gctgtgggaa gtggagcacg actcatttct gtttgttact ttgagtctga aaatgactgg      540



tgggtgagca agcacattaa aaagccgatt cgctccacag tcctcagctt ggattggcat      600



cccaacaacg ttttgctggc agcaggatca tgtgacttca aatgcagagt gttttctgcc      660



tacattaaag aagtggatga aaagccagcc agcacgccct ggggcagcaa gatgcctttt      720



gggcagctga tgtcagagtt tggtggcagt ggcactggtg gctgggtcca cggggtaagc      780



ttctctgcca gtgggagccg cctggcctgg gtcagccacg acagcaccgt gtctgttgct      840



gatgcctcaa aaagtgtgca ggtctcgact ctgaagacag agttcctgcc gctcctaagt      900



gtgtcatttg tctcagagaa cagcgtcgtg gctgctggcc atgactgctg cccaatgctc      960



tttaactacg atgaccgcgg ctgcctgacc ttcgtctcca agttagatat tccaaaacag     1020



agcatccaac gcaacatgtc tgccatggaa cgcttccgca acatggacaa gagagccaca     1080



actgaggacc gcaacacggc cttggagacg ctgcaccaga atagcatcac tcaagtctct     1140



atttatgagg tggacaagca agattgtcgc aaattttgca ctactggcat cgatggagcc     1200



atgacaattt gggatttcaa gaccctcgag tcttccatcc agggcctccg gataatgtga     1260



agctgagtga gcctccgcca tccagcatga caaactgtgg ccgaccgcag ctgtgccgtg     1320



gcacgatggc gaggaagcca gccccaagga aacactgaaa acacatatca cgccaatgcc     1380



gtgtggtttt gtttgaatat aaaattggtg aaagtgttgg tttttttaag gcagtaattt     1440



ttttgtttgt ttttttgcga tttcattcca ttcttgacca aagcttctct ttaagtagtt     1500



tattatggaa aattgtcaca ctaacttaaa agacagggtg agggagatat gtaaattgtc     1560



cactagaaaa ttaaataaaa gaactgaatg tggaaaaaaa aaaaaaaaaa aaaaaaaaa      1619





<210>  40

<211>  370

<212>  PRT

<213>  Homo sapiens



<400>  40



Met Ser Leu His Gln Phe Leu Leu Glu Pro Ile Thr Cys His Ala Trp 

1               5                   10                  15      





Asn Arg Asp Arg Thr Gln Ile Ala Leu Ser Pro Asn Asn His Glu Val 

            20                  25                  30          





His Ile Tyr Lys Lys Asn Gly Ser Gln Trp Val Lys Ala His Glu Leu 

        35                  40                  45              





Lys Glu His Asn Gly His Ile Thr Gly Ile Asp Trp Ala Pro Lys Ser 

    50                  55                  60                  





Asp Arg Ile Val Thr Cys Gly Ala Asp Arg Asn Ala Tyr Val Trp Ser 

65                  70                  75                  80  





Gln Lys Asp Gly Val Trp Lys Pro Thr Leu Val Ile Leu Arg Ile Asn 

                85                  90                  95      





Arg Ala Ala Thr Phe Val Lys Trp Ser Pro Leu Glu Asn Lys Phe Ala 

            100                 105                 110         





Val Gly Ser Gly Ala Arg Leu Ile Ser Val Cys Tyr Phe Glu Ser Glu 

        115                 120                 125             





Asn Asp Trp Trp Val Ser Lys His Ile Lys Lys Pro Ile Arg Ser Thr 

    130                 135                 140                 





Val Leu Ser Leu Asp Trp His Pro Asn Asn Val Leu Leu Ala Ala Gly 

145                 150                 155                 160 





Ser Cys Asp Phe Lys Cys Arg Val Phe Ser Ala Tyr Ile Lys Glu Val 

                165                 170                 175     





Asp Glu Lys Pro Ala Ser Thr Pro Trp Gly Ser Lys Met Pro Phe Gly 

            180                 185                 190         





Gln Leu Met Ser Glu Phe Gly Gly Ser Gly Thr Gly Gly Trp Val His 

        195                 200                 205             





Gly Val Ser Phe Ser Ala Ser Gly Ser Arg Leu Ala Trp Val Ser His 

    210                 215                 220                 





Asp Ser Thr Val Ser Val Ala Asp Ala Ser Lys Ser Val Gln Val Ser 

225                 230                 235                 240 





Thr Leu Lys Thr Glu Phe Leu Pro Leu Leu Ser Val Ser Phe Val Ser 

                245                 250                 255     





Glu Asn Ser Val Val Ala Ala Gly His Asp Cys Cys Pro Met Leu Phe 

            260                 265                 270         





Asn Tyr Asp Asp Arg Gly Cys Leu Thr Phe Val Ser Lys Leu Asp Ile 

        275                 280                 285             





Pro Lys Gln Ser Ile Gln Arg Asn Met Ser Ala Met Glu Arg Phe Arg 

    290                 295                 300                 





Asn Met Asp Lys Arg Ala Thr Thr Glu Asp Arg Asn Thr Ala Leu Glu 

305                 310                 315                 320 





Thr Leu His Gln Asn Ser Ile Thr Gln Val Ser Ile Tyr Glu Val Asp 

                325                 330                 335     





Lys Gln Asp Cys Arg Lys Phe Cys Thr Thr Gly Ile Asp Gly Ala Met 

            340                 345                 350         





Thr Ile Trp Asp Phe Lys Thr Leu Glu Ser Ser Ile Gln Gly Leu Arg 

        355                 360                 365             





Ile Met 

    370 





<210>  41

<211>  7174

<212>  DNA

<213>  Homo sapiens



<400>  41

agcggcggta gcagtggcaa cggcagcaag aggaccggcc gccccataga cccccccgcg       60



caccaccccc gccgcttcct ctgcttgggt gcccccccgg tctgacttcc cttttctccc      120



acctttcccg gcaccgcggg aaaagcagcg cagggcagag caggcaggga gggcggccgg      180



agcccggaca cgggagcctc ccagtcagtt caagacccga catgagggaa aagggacgta      240



ggaagaaggg caggacctgg gcggaggccg ccaagacggt cttagaaaaa taccccaata      300



cacccatgag tcataaagaa attcttcaag ttatccagag agaaggacta aaagaaatca      360



gaagtgggac ttctcctctt gcatgcctga atgcaatgct tcacacaaac tccagaggtg      420



aagagggcat cttctataag gttccaggta gaatgggagt atatactttg aagaaagatg      480



tgccggatgg ggtgaaagag ctgtcagaag gttcagaaga aagcagtgat ggtcagtcag      540



attcccagag ttctgagaac agcagcagca gcagtgatgg tggcagcaac aaggagggaa      600



aaaagagcag gtggaaaagg aaagtatcgt cgtcctcccc gcagtcaggc tgcccatcac      660



ccaccattcc agcaggtaaa gtcatttctc catcacagaa gcacagcaag aaggcactaa      720



agcaggcgct aaagcagcaa cagcagaaga agcagcagca gcaatgcagg ccaagcatat      780



ccatctcctc caaccagcat ctctcactaa agactgtcaa agcagccagt gactctgtac      840



ctgccaaacc tgcaacatgg gaaggaaagc aatctgatgg acagacaggc agccctcaaa      900



actcaaactc cagcttttct tcctcagtta aagtggaaaa tactttacta ggcttgggga      960



agaagtcatt ccagagatct gagagactcc ataccagaca aatgaaaaga actaaatgtg     1020



ctgacattga cgttgagaca ccggactcca ttctggttaa tacaaatctg cgagcactga     1080



tcaacaagca cacattttca gtccttcctg gagattgcca gcaacgactg cttttactac     1140



tcccagaggt agatcgacag gttggtccag atggtttaat gaagttaaat ggctcagccc     1200



ttaacaatga attcttcact tcagcagccc aaggctggaa ggaaagactc tcagaaggtg     1260



agtttacacc tgagatgcag gtgagaattc gacaagagat tgagaaggag aaaaaagtgg     1320



agccatggaa agaacaattc tttgaaagct actatgggca gagttctggc ctgagccttg     1380



aagattctaa gaaattgaca gcttctccca gtgatcccaa agtaaagaaa accccagctg     1440



aacaaccaaa atccatgcct gtgtcagagg cctctcttat cagaatagtt ccagtagtct     1500



cccagtcaga gtgtaaagaa gaagcattgc aaatgtcatc accaggcaga aaagaagagt     1560



gtgaaagcca aggtgaagtg cagccgaact tctccacatc ttcagagccc ctgctttcct     1620



cagctctcaa tacacatgag cttagcagca ttcttcccat caagtgccca aaggatgagg     1680



atctcttgga gcagaagcca gtcacctctg ctgaacagga atctgagaag aaccatctca     1740



ccacagcttc taattataac aaaagtgaaa gccaagaatc tttagttaca tcgccaagca     1800



aacccaagag tcctggggtt gaaaaaccaa tagtgaagcc cacagcagga gcgggtccac     1860



aggagactaa tatgaaagaa cctctagcaa ctcttgttga tcagagccca gaaagcctca     1920



agaggaagtc ttccctcacc caagaagagg cccctgtgag ctgggagaag aggccacgtg     1980



tcactgagaa tcgccagcac cagcagccat ttcaggtctc accacagccc tttctcaata     2040



gaggggacag aatccaggtg cgaaaagtac cacctctcaa gatcccggtc tccagaatct     2100



cccccatgcc gtttcatcca tcgcaggtct ctcccagggc tcgttttcca gtctccatca     2160



ctagtcctaa cagaacagga gccagaactc ttgcagacat caaagcaaaa gcccaactgg     2220



tcaaagcaca gagggcagca gctgccgctg ccgccgcagc tgctgcagcc gcctcagttg     2280



gagggaccat tccaggacct ggcccagggg gtggacaagg tccaggagag ggtggtgaag     2340



ggcagactgc tagaggaggc agtccaggct cagacagagt cagtgaaact ggaaagggcc     2400



ccacactgga actggcagga actggaagca ggggaggtac gagagagctt ttaccctgtg     2460



gtccagagac tcagccccag tctgagacca agaccacccc aagccaggca cagcctcata     2520



gtgtctctgg agcacaacta cagcaaaccc ccccagtgcc tccaacacct gccgtcagtg     2580



gagcatgcac aagtgtccca tcaccagccc acatagagaa attggataat gaaaaactga     2640



accccaccag agcaacagcc acagtggcct ctgtcagcca tccacaaggg cccagtagtt     2700



gcagacagga gaaagcacct tctccaacag gtcctgctct aatctcaggt gcctcacctg     2760



ttcattgtgc agctgatggc acagttgagc tcaaagcagg tcctagtaag aatataccta     2820



acccttcagc ctcatcaaag acagatgcta gtgtgccagt ggctgtaact ccctcccctt     2880



taacatcttt attgaccaca gccactttag aaaagcttcc tgtaccccag gtcagtgcaa     2940



ctacagcacc tgctggatca gctccaccct cgagcacttt gccagcagct tctagcctta     3000



aaaccccagg aacttcttta aacatgaatg gacccacttt aagaccaacc tctagtatcc     3060



ctgctaataa tcctttagtg actcagctgc ttcaaggcaa agatgttccc atggagcaaa     3120



ttctgcctaa acctctcacc aaagttgaaa tgaaaacggt tccactgact gcaaaagagg     3180



aaagggggat gggagcgctc atagctacca acacaacaga aaatagcacc agagaggaag     3240



ttaatgagag acagtcccat ccagctacgc agcagcagct gggcaaaacc ttgcaaagta     3300



agcagctccc ccaggttcca aggccccttc agctcttttc agctaaggag ctgagggact     3360



ccagcattga cacacaccaa taccacgaag gactaagtaa agcaacccaa gatcagatcc     3420



ttcagactct cattcagagg gttcggaggc agaatcttct ctcagttgtg ccgccctcac     3480



agttcaactt cgctcactca ggtttccagc tggaagacat ctccacaagc cagaggttca     3540



tgctgggttt tgctggcaga aggacatcca aacctgcaat ggcagggcac tacttactga     3600



atatttctac ctacggccgg ggctcagaga gctttaggag gacccattct gtaaaccctg     3660



aagatcgttt ttgtctaagc agccccactg aagccttgaa aatgggatat acagactgta     3720



aaaatgcaac aggagagagt agcagcagca aagaagatga cactgatgag gaaagtactg     3780



gtgatgagca ggaatctgtc acagtgaaag aggagcccca ggtttcccag agtgctggca     3840



agggtgacac aagttcagga cctcacagca gggaaactct atctaccagt gattgcttag     3900



ctagcaagaa tgtgaaggct gagataccat tgaatgagca aaccacttta agtaaggaga     3960



attacctgtt cactagaggc caaacatttg atgaaaagac cctagccaga gatttaattc     4020



aggcagcaca gaagcagatg gctcatgcag tgagaggtaa ggcaatccgt agcagccccg     4080



agcttttcag ttctactgtt cttcctctgc ctgcagacag ccccacccac cagcccctac     4140



tccttccacc cctgcaaacc ccgaagttgt atggaagccc cacccagata gggccaagct     4200



atagaggcat gatcaatgtc tccacctcat ctgacatgga ccataactct gctgtaccag     4260



gtagccaggt atctagcaat gtaggtgatg tcatgtcatt ttcagtgact gtcactacca     4320



tccctgctag ccaagctatg aatcccagca gccatggcca gaccattcct gttcaggcgt     4380



tctccgaaga gaacagcata gagggcacgc cttcgaaatg ttactgccgc ttgaaagcca     4440



tgatcatgtg caaaggctgt ggcgctttct gccatgatga ttgcatcggc ccctccaaac     4500



tgtgcgtctc ctgccttgtc gttcggtaat gagactagaa agagatacac tgtaaaggag     4560



ggggaaggga agggttgacc agttgggttt tttgcgtcct tttggaatca cagaaataaa     4620



caagtaggtt tcagttgtct tcagagacaa atgttactta atcaggaata caaagtacag     4680



attttttaca ttttagagga agagcacctt gtatagtaag tctaagtcaa gcaagacttt     4740



gtgaatttgt gacaagtttg cacttacaaa atcatgtaaa tatgtcacat tttgtttaac     4800



attatttttc caagtgttta ggtaataatg tattactttg aattcagatt aatgttctac     4860



tacttgtgac tgagaaaagt ttaatgccgg catggtaaaa ggaagctgtc tcccttctga     4920



catttcctag gaagctagga aaaggaaagt gaaggaatgg tctaaagaaa tgaccattca     4980



cactgatttt gtctggacag tctggccgca ggttattcat agattattca gcctttgcag     5040



gacttggatt cagggtttta ctcagtccct ttaccttagg tggaatcttc ttaaattgaa     5100



atttttggta aggaattcat ttcacaggta gtgtttcaga ctctgaaagc cctgacttgg     5160



ttcttggctt ctactgtact agttactagt tactggtact gttgccaagc aatctgcttg     5220



gaatttgtgg atccctgctg ttccctaatc ccaccccctg ccctgagaca gtgaatgtag     5280



tccgtgaagg gagtgcctct ctgggacccc ctgtgttgtt acaggctgtg cagtgcaaca     5340



attccagcaa aaatacccta tccccgcact tagtcattcg tggtaactaa caattttgaa     5400



atactcatat aaaatgaaca ggaaagtgtt agtgattggg tgatttgagc tacatcttgt     5460



tgagcaaggg gagtgaaacc acagaaactg ttaaattgaa cgtaaataac tttggaaaac     5520



agttttgaca ctagaacaag gtcgcttctc ttttcctctt ctctcccaac ctgttaacct     5580



agtgctagat agtcagctgc tgttgcaggt agaaaagctc accaatgcca catttgttca     5640



ttctgttcaa cctgttttga cctcccaggc atctgaacag gatgacatca tcttattata     5700



tcttacttta cacatacgtg tatgtacaca cacacacaca atacaagaca tttttcctgt     5760



tttagaaaat atagcccttg tttggattac tgctgtctga gcactagaaa tttctaatgg     5820



aaagaggcct ctgaatggct aagggaacat ctggaaagga aggaaaatga gccctaaagg     5880



ttttttggtt gcttgttttt gtttcttttt ctttcttgtt tccttttttg tttttaaatc     5940



cttctctagt gactgaagaa attgtgagta cataatattt aggtcatggt taaggaacat     6000



taaaataaac ctgcagttta acagaatttt gtattaaatg ggggagtgtc aatttgcatc     6060



atttgcatat tgatttcaag tctcctaatt tggaatgggt aaagtacaaa tgttaatgca     6120



acatagtaca gttgtatttg tccttcatat tcaggatgtg atatttacaa aatgcagaac     6180



agtttaaact tgttaagtca cattccagat taggagaaaa tgggcaataa tcatctctgt     6240



tttgccccca ttctactacc caccactgcc caccccaccc ccacatcaca cactcttcga     6300



tgctttccca cagcccctgc tccgctcctc tccgtaagaa actcacttca ctgtttttca     6360



cttttcactt ctggcttttt tgtggcccaa ggccaatata ggattaatat ctgtgttcca     6420



gcttcagcca gaacgatatg tctgtccatc tttctccttt cttccagcac acacagctaa     6480



gagataagaa ggctgcaagg attggggata aggagtatat tttcaagcca agaaccagta     6540



gaaaacagaa ataatggtgc tcccaaatat tcagtacctt gggcaatcca ggaagggttt     6600



aaagagacct gttgctgcat agaactctcc ctgccctacc ccttaactcc accttagtgc     6660



cagggccgag ggctggtctg catgctggaa gaggttgaga gttttggaat tgattccatg     6720



ctaaatgtca gttaccagtt tggattgatg aaagtgattt ttctgcttta cctttttcct     6780



gtcagaaagg ttttcctctg tgctaccctt aacttaggga tgaacagact ataactagga     6840



aaggaggaaa ggtatcaggg atttttaagt ccgtttagag agcaaaccat attgtgcctc     6900



ttcatcttga cccaggctct tatagatagg tcctaaacat tgctgttcac tagattatct     6960



taacaaataa tactcagcta aatatttgca tttaggaata ctcctaaaac agatattgcc     7020



aactagatac actgcctcaa tcttgaccag acaagagaac agttaagttc tctcagttgg     7080



gtagtaactt gaataccagt ctatttatca gttggtttca acacagaggt ttcaagtgga     7140



aagccattca tcttaaaagc tgaacagaaa aatt                                 7174





<210>  42

<211>  1435

<212>  PRT

<213>  Homo sapiens



<400>  42



Met Arg Glu Lys Gly Arg Arg Lys Lys Gly Arg Thr Trp Ala Glu Ala 

1               5                   10                  15      





Ala Lys Thr Val Leu Glu Lys Tyr Pro Asn Thr Pro Met Ser His Lys 

            20                  25                  30          





Glu Ile Leu Gln Val Ile Gln Arg Glu Gly Leu Lys Glu Ile Arg Ser 

        35                  40                  45              





Gly Thr Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Thr Asn Ser 

    50                  55                  60                  





Arg Gly Glu Glu Gly Ile Phe Tyr Lys Val Pro Gly Arg Met Gly Val 

65                  70                  75                  80  





Tyr Thr Leu Lys Lys Asp Val Pro Asp Gly Val Lys Glu Leu Ser Glu 

                85                  90                  95      





Gly Ser Glu Glu Ser Ser Asp Gly Gln Ser Asp Ser Gln Ser Ser Glu 

            100                 105                 110         





Asn Ser Ser Ser Ser Ser Asp Gly Gly Ser Asn Lys Glu Gly Lys Lys 

        115                 120                 125             





Ser Arg Trp Lys Arg Lys Val Ser Ser Ser Ser Pro Gln Ser Gly Cys 

    130                 135                 140                 





Pro Ser Pro Thr Ile Pro Ala Gly Lys Val Ile Ser Pro Ser Gln Lys 

145                 150                 155                 160 





His Ser Lys Lys Ala Leu Lys Gln Ala Leu Lys Gln Gln Gln Gln Lys 

                165                 170                 175     





Lys Gln Gln Gln Gln Cys Arg Pro Ser Ile Ser Ile Ser Ser Asn Gln 

            180                 185                 190         





His Leu Ser Leu Lys Thr Val Lys Ala Ala Ser Asp Ser Val Pro Ala 

        195                 200                 205             





Lys Pro Ala Thr Trp Glu Gly Lys Gln Ser Asp Gly Gln Thr Gly Ser 

    210                 215                 220                 





Pro Gln Asn Ser Asn Ser Ser Phe Ser Ser Ser Val Lys Val Glu Asn 

225                 230                 235                 240 





Thr Leu Leu Gly Leu Gly Lys Lys Ser Phe Gln Arg Ser Glu Arg Leu 

                245                 250                 255     





His Thr Arg Gln Met Lys Arg Thr Lys Cys Ala Asp Ile Asp Val Glu 

            260                 265                 270         





Thr Pro Asp Ser Ile Leu Val Asn Thr Asn Leu Arg Ala Leu Ile Asn 

        275                 280                 285             





Lys His Thr Phe Ser Val Leu Pro Gly Asp Cys Gln Gln Arg Leu Leu 

    290                 295                 300                 





Leu Leu Leu Pro Glu Val Asp Arg Gln Val Gly Pro Asp Gly Leu Met 

305                 310                 315                 320 





Lys Leu Asn Gly Ser Ala Leu Asn Asn Glu Phe Phe Thr Ser Ala Ala 

                325                 330                 335     





Gln Gly Trp Lys Glu Arg Leu Ser Glu Gly Glu Phe Thr Pro Glu Met 

            340                 345                 350         





Gln Val Arg Ile Arg Gln Glu Ile Glu Lys Glu Lys Lys Val Glu Pro 

        355                 360                 365             





Trp Lys Glu Gln Phe Phe Glu Ser Tyr Tyr Gly Gln Ser Ser Gly Leu 

    370                 375                 380                 





Ser Leu Glu Asp Ser Lys Lys Leu Thr Ala Ser Pro Ser Asp Pro Lys 

385                 390                 395                 400 





Val Lys Lys Thr Pro Ala Glu Gln Pro Lys Ser Met Pro Val Ser Glu 

                405                 410                 415     





Ala Ser Leu Ile Arg Ile Val Pro Val Val Ser Gln Ser Glu Cys Lys 

            420                 425                 430         





Glu Glu Ala Leu Gln Met Ser Ser Pro Gly Arg Lys Glu Glu Cys Glu 

        435                 440                 445             





Ser Gln Gly Glu Val Gln Pro Asn Phe Ser Thr Ser Ser Glu Pro Leu 

    450                 455                 460                 





Leu Ser Ser Ala Leu Asn Thr His Glu Leu Ser Ser Ile Leu Pro Ile 

465                 470                 475                 480 





Lys Cys Pro Lys Asp Glu Asp Leu Leu Glu Gln Lys Pro Val Thr Ser 

                485                 490                 495     





Ala Glu Gln Glu Ser Glu Lys Asn His Leu Thr Thr Ala Ser Asn Tyr 

            500                 505                 510         





Asn Lys Ser Glu Ser Gln Glu Ser Leu Val Thr Ser Pro Ser Lys Pro 

        515                 520                 525             





Lys Ser Pro Gly Val Glu Lys Pro Ile Val Lys Pro Thr Ala Gly Ala 

    530                 535                 540                 





Gly Pro Gln Glu Thr Asn Met Lys Glu Pro Leu Ala Thr Leu Val Asp 

545                 550                 555                 560 





Gln Ser Pro Glu Ser Leu Lys Arg Lys Ser Ser Leu Thr Gln Glu Glu 

                565                 570                 575     





Ala Pro Val Ser Trp Glu Lys Arg Pro Arg Val Thr Glu Asn Arg Gln 

            580                 585                 590         





His Gln Gln Pro Phe Gln Val Ser Pro Gln Pro Phe Leu Asn Arg Gly 

        595                 600                 605             





Asp Arg Ile Gln Val Arg Lys Val Pro Pro Leu Lys Ile Pro Val Ser 

    610                 615                 620                 





Arg Ile Ser Pro Met Pro Phe His Pro Ser Gln Val Ser Pro Arg Ala 

625                 630                 635                 640 





Arg Phe Pro Val Ser Ile Thr Ser Pro Asn Arg Thr Gly Ala Arg Thr 

                645                 650                 655     





Leu Ala Asp Ile Lys Ala Lys Ala Gln Leu Val Lys Ala Gln Arg Ala 

            660                 665                 670         





Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Val Gly Gly 

        675                 680                 685             





Thr Ile Pro Gly Pro Gly Pro Gly Gly Gly Gln Gly Pro Gly Glu Gly 

    690                 695                 700                 





Gly Glu Gly Gln Thr Ala Arg Gly Gly Ser Pro Gly Ser Asp Arg Val 

705                 710                 715                 720 





Ser Glu Thr Gly Lys Gly Pro Thr Leu Glu Leu Ala Gly Thr Gly Ser 

                725                 730                 735     





Arg Gly Gly Thr Arg Glu Leu Leu Pro Cys Gly Pro Glu Thr Gln Pro 

            740                 745                 750         





Gln Ser Glu Thr Lys Thr Thr Pro Ser Gln Ala Gln Pro His Ser Val 

        755                 760                 765             





Ser Gly Ala Gln Leu Gln Gln Thr Pro Pro Val Pro Pro Thr Pro Ala 

    770                 775                 780                 





Val Ser Gly Ala Cys Thr Ser Val Pro Ser Pro Ala His Ile Glu Lys 

785                 790                 795                 800 





Leu Asp Asn Glu Lys Leu Asn Pro Thr Arg Ala Thr Ala Thr Val Ala 

                805                 810                 815     





Ser Val Ser His Pro Gln Gly Pro Ser Ser Cys Arg Gln Glu Lys Ala 

            820                 825                 830         





Pro Ser Pro Thr Gly Pro Ala Leu Ile Ser Gly Ala Ser Pro Val His 

        835                 840                 845             





Cys Ala Ala Asp Gly Thr Val Glu Leu Lys Ala Gly Pro Ser Lys Asn 

    850                 855                 860                 





Ile Pro Asn Pro Ser Ala Ser Ser Lys Thr Asp Ala Ser Val Pro Val 

865                 870                 875                 880 





Ala Val Thr Pro Ser Pro Leu Thr Ser Leu Leu Thr Thr Ala Thr Leu 

                885                 890                 895     





Glu Lys Leu Pro Val Pro Gln Val Ser Ala Thr Thr Ala Pro Ala Gly 

            900                 905                 910         





Ser Ala Pro Pro Ser Ser Thr Leu Pro Ala Ala Ser Ser Leu Lys Thr 

        915                 920                 925             





Pro Gly Thr Ser Leu Asn Met Asn Gly Pro Thr Leu Arg Pro Thr Ser 

    930                 935                 940                 





Ser Ile Pro Ala Asn Asn Pro Leu Val Thr Gln Leu Leu Gln Gly Lys 

945                 950                 955                 960 





Asp Val Pro Met Glu Gln Ile Leu Pro Lys Pro Leu Thr Lys Val Glu 

                965                 970                 975     





Met Lys Thr Val Pro Leu Thr Ala Lys Glu Glu Arg Gly Met Gly Ala 

            980                 985                 990         





Leu Ile Ala Thr Asn Thr Thr Glu  Asn Ser Thr Arg Glu  Glu Val Asn 

        995                 1000                 1005             





Glu Arg  Gln Ser His Pro Ala  Thr Gln Gln Gln Leu  Gly Lys Thr 

    1010                 1015                 1020             





Leu Gln  Ser Lys Gln Leu Pro  Gln Val Pro Arg Pro  Leu Gln Leu 

    1025                 1030                 1035             





Phe Ser  Ala Lys Glu Leu Arg  Asp Ser Ser Ile Asp  Thr His Gln 

    1040                 1045                 1050             





Tyr His  Glu Gly Leu Ser Lys  Ala Thr Gln Asp Gln  Ile Leu Gln 

    1055                 1060                 1065             





Thr Leu  Ile Gln Arg Val Arg  Arg Gln Asn Leu Leu  Ser Val Val 

    1070                 1075                 1080             





Pro Pro  Ser Gln Phe Asn Phe  Ala His Ser Gly Phe  Gln Leu Glu 

    1085                 1090                 1095             





Asp Ile  Ser Thr Ser Gln Arg  Phe Met Leu Gly Phe  Ala Gly Arg 

    1100                 1105                 1110             





Arg Thr  Ser Lys Pro Ala Met  Ala Gly His Tyr Leu  Leu Asn Ile 

    1115                 1120                 1125             





Ser Thr  Tyr Gly Arg Gly Ser  Glu Ser Phe Arg Arg  Thr His Ser 

    1130                 1135                 1140             





Val Asn  Pro Glu Asp Arg Phe  Cys Leu Ser Ser Pro  Thr Glu Ala 

    1145                 1150                 1155             





Leu Lys  Met Gly Tyr Thr Asp  Cys Lys Asn Ala Thr  Gly Glu Ser 

    1160                 1165                 1170             





Ser Ser  Ser Lys Glu Asp Asp  Thr Asp Glu Glu Ser  Thr Gly Asp 

    1175                 1180                 1185             





Glu Gln  Glu Ser Val Thr Val  Lys Glu Glu Pro Gln  Val Ser Gln 

    1190                 1195                 1200             





Ser Ala  Gly Lys Gly Asp Thr  Ser Ser Gly Pro His  Ser Arg Glu 

    1205                 1210                 1215             





Thr Leu  Ser Thr Ser Asp Cys  Leu Ala Ser Lys Asn  Val Lys Ala 

    1220                 1225                 1230             





Glu Ile  Pro Leu Asn Glu Gln  Thr Thr Leu Ser Lys  Glu Asn Tyr 

    1235                 1240                 1245             





Leu Phe  Thr Arg Gly Gln Thr  Phe Asp Glu Lys Thr  Leu Ala Arg 

    1250                 1255                 1260             





Asp Leu  Ile Gln Ala Ala Gln  Lys Gln Met Ala His  Ala Val Arg 

    1265                 1270                 1275             





Gly Lys  Ala Ile Arg Ser Ser  Pro Glu Leu Phe Ser  Ser Thr Val 

    1280                 1285                 1290             





Leu Pro  Leu Pro Ala Asp Ser  Pro Thr His Gln Pro  Leu Leu Leu 

    1295                 1300                 1305             





Pro Pro  Leu Gln Thr Pro Lys  Leu Tyr Gly Ser Pro  Thr Gln Ile 

    1310                 1315                 1320             





Gly Pro  Ser Tyr Arg Gly Met  Ile Asn Val Ser Thr  Ser Ser Asp 

    1325                 1330                 1335             





Met Asp  His Asn Ser Ala Val  Pro Gly Ser Gln Val  Ser Ser Asn 

    1340                 1345                 1350             





Val Gly  Asp Val Met Ser Phe  Ser Val Thr Val Thr  Thr Ile Pro 

    1355                 1360                 1365             





Ala Ser  Gln Ala Met Asn Pro  Ser Ser His Gly Gln  Thr Ile Pro 

    1370                 1375                 1380             





Val Gln  Ala Phe Ser Glu Glu  Asn Ser Ile Glu Gly  Thr Pro Ser 

    1385                 1390                 1395             





Lys Cys  Tyr Cys Arg Leu Lys  Ala Met Ile Met Cys  Lys Gly Cys 

    1400                 1405                 1410             





Gly Ala  Phe Cys His Asp Asp  Cys Ile Gly Pro Ser  Lys Leu Cys 

    1415                 1420                 1425             





Val Ser  Cys Leu Val Val Arg  

    1430                 1435 





<210>  43

<211>  4544

<212>  DNA

<213>  Homo sapiens



<400>  43

cagcccggcc ggggcctgcg ggcgcccaga gccgcgccgt ccgcgccgcc cgttctggtt       60



ggaagtactc catgacacac actcggagaa agtcccttcc catgctgagt tcgggcctca      120



ctggccgccg agagcccctg cagatggaag acagcaacat ggagcagggg gttgagggtg      180



tggagccagg catgcccgag agcccaggtc acctcacagg gcgccgcaag aattacccac      240



ttcgtaagcg cccattggtt cctgagaagc ccaaggcctg caaagtgctg ctgactcgcc      300



tggagaatgt ggccggtccc cggagtgcag atgaggctga tgagctaccg cctgacctgc      360



ccaagccccc cagcccggcc ccatccagtg aagaccctgg ccttgcccag ccccgcaagc      420



ggcgcctggc ctccctcaat gctgaagctc tcaataacct gctgctggag cgagaggaca      480



ccagcagcct ggcaggcacc cgccgcagtc gagcagggga tccccaccgc agccgtgacc      540



gtgatcgtgc tactgggggc tggtcctcct ccaagaagcg gccccggctg ggggaccttg      600



gaggaggaag tcgggacctg tctccagagc cagcacccga tgaaggtccc cgccgagatg      660



gagacccagc tcccaagaga ctggctagcc tgaacgcagc tgctttccta aaactgagcc      720



aggagcggga gctacccctg cggctgcctc gtgcccatgc agaagtagat gggcgctcca      780



ctgagccccc agcacccaag gccccgaggc caaagtggcc caaggtcaat ggcaagaact      840



atcccaaggc ttggcagggg gccagctctg gggaggctgc aggcccacct ggctggcaag      900



gctgccctga tgaaccatgg ccatctgcaa ctccttgtgg gccatccgtc cagccatctc      960



atcagcccct gagcaaggct ctggagagcc ctttggggct gcgccctcac ctgcccctgc     1020



tgatgggtgg acaggcggct ctgaagccgg agcctgggcg cccaggcgag gagtcacctg     1080



cccctaagca ggaactgcat cagccctctt tccccacacc tcagctgtcg ccgctgccga     1140



tgcctggcaa ccccgccgac tacaatggcc tgtgtgttgg gcctgagctc actgcactag     1200



gcagcttcta cctgtactgt ggccaagagg ggctgcagtg tgggggctac tcgccctgcc     1260



ccatgcttcc tgagggcaag ctgtccccag tggctgcacc tcacgaggag gggctcctct     1320



tagctccgag ctcagtgccc tcaggcaccc ctttccagca ccctccctgg ggctcctctc     1380



gctactgctc tagcgaggac actggagtga atggctacag catctgcgga gtgttgcccc     1440



tgtctgttac ccacgctggc actacctgtg gcggctgccc atacaaaatg ccttttgcag     1500



cagaaggctg cagatccctg ggccagttgg aatttcctct cccggaagct ggccacccag     1560



cctcacccgc ccacccactc ctggggtgcc ctgtacccag tgtgccacct gcagcagagc     1620



ccgtccccca tcttcagaca cccacctcgg agccccagac agtagcccgt gcgtgccctc     1680



agagcgccaa acctcccagc ggttctaagt caggtctgcg cacaggctcc agctgcaggc     1740



acactgcaag gagcaaggct gcccgcaggc ctagccaccc caagcagcca cgtgtccagc     1800



gcccacgccc tcgccgccgc cgtcgccgcc gcactaatgg ctgggtacct gttggggctg     1860



cgtgtgagaa ggctgtgtat gtcttggatg agccggagcc agccatccga aagagctacc     1920



aggcggtaga gcggcatggg gagacaatcc gagtccggga caccgtcctt ctcaaatcag     1980



gcccacgaaa gacctccaca ccttatgtgg ccaagatctc tgccctctgg gagaaccccg     2040



agtcaggaga gctgatgatg agcctcctgt ggtattacag acctgagcac ttacagggag     2100



gccgcagtcc cagcatgcac gagcccttgc agaatgaagt gtttgcatcg cgacatcagg     2160



accagaacag tgtggcctgc attgaggaga agtgctatgt gctgactttt gccgagtact     2220



gcaggttctg tgccatggcc aagcgccgag gtgaaggcct ccccagccga aagacagcac     2280



tggttccccc ctctgcagac tattccaccc caccccaccg cacagtgcca gaggacacgg     2340



accctgagct ggtgttcctt tgccgccatg tctatgactt ccgccacggg cgcatcctta     2400



agaaccccca gtagcctcct catgcccatg ctggggctac ccatgggcaa gtggggctcg     2460



gggtaggggg cactgcttga agcacagcac ttggttaggg ggccacagag gcctaagttt     2520



gctggcctgt ggttttcttg ggggggaggg caggggcccc tgtgggttct gggctccagg     2580



ggagggagct ggggaggcca gggtataaga aaagcatcag aactctcagc ttggcccaag     2640



gtaccttctg tggttcccct gggtggagat ttccgaaaag tagtcttctc tgaggctggg     2700



ccaagcctga gggaaatggg gccctaggag ggtgggggcg ggaaggaggg gcaaggtctt     2760



tcaggaacca gacccaacag gcccttctgt agcctccccc ttgccctcaa agggggagtg     2820



ggggccagct ttacctcacc cactgtgacc cgccgcttcc ccttcagcct gggaccaggc     2880



tttcctagat cccagcacag ctctgagctt gttcctttga ggcatagaga gccagagtct     2940



ggcttccaga gcattgactt cctcttccta gacttgaggc cttttctctg gctttcctcc     3000



tttgccctgc agtagcaact ggtgctggga caagttgacc cacctctcac agtcatgggt     3060



gtggcccact tgtgggagtc tcctgtccac ctcccagaga cggccaccca gcgggtctgg     3120



cttcccagaa agttaactga tgattgtggg gtttgtcata tctgggaggg aagatgggtg     3180



ctgggagagg gttgggggca gggggcaagg aaaattgcta cctgatttgt tgaagatttt     3240



tcctcttgcc ttacacatgg aggttccagg aaacctcttg cagaacttca cacgtgattc     3300



ttcaagccac acccacctga aatcaaacca aaggagtgct gtggctcccc ttgccctgcc     3360



accctttccc tagtcttttg tagattgcac taatttacat cctagcaaga atcaacactg     3420



tatcagtcca cggacctgct gagctgcagc cacttgctct aggagctaag gacttgcatt     3480



ttcagtttgt tcctgttgcc cagaggccct gttctcacct catgctgctc cccagagtag     3540



actaacaggc tcagtcccct gttgtccttg tggagactag gccttggccc tggccctgag     3600



actctgtgag ggggctggag cagcctggtt atttcctatc tgtaccaaag aggagtatgg     3660



tgggagaggg agtggagtgc agtgtggctt gggcctggtg ctgggaacct gctagctgag     3720



cacttccaca agggcatacc cctgggggca ggggctgggg ctgagaactg cagccctggg     3780



tcttccctta gggaggaagg gcagatgaac ccagcaggct taggaggtgg cactgggtga     3840



ggacagctgg gcaggggctg cagagggagg tggaaatgaa ccctgagggc tcccccaact     3900



tgccatgccc tgtcccttag tagatgagtt gctcctgatt ggtcattggg tttgggtgag     3960



gcctggaggc ttcagaggtg aatttatgct tgggaagcct gatcccaaac ctgaagggaa     4020



gggacttgga tctccttata ttgaataagc tgtttggagg aaggtgtctg tctgggagga     4080



tggggcagta aatgaggttg gcagagtggc agtgggggct ctgcagagcc agccttggag     4140



cctgctcatt ctgggccctt gctgccaagg agcccagcct cacctagcag gaaaggagat     4200



gaaggccctc ctcccaggag gtagggtctt ggctgccccg aacttaaatg cttttgaaat     4260



ctcttagatg tggaaatatt ttttcgaacc tgaaaatgca gctggtagaa tttcaatgga     4320



agcataatcc atgtaaaata tattttagtt gatattttgt aaaatgcact ttttgtgtgt     4380



gttgatcctg gtttcccaga tctgtatttc agtgtttaca agggaggaag gacctttcct     4440



cacctccctt ttgacagaga ttagaagtac ttctttaaga aaaaaataaa tttgagaaat     4500



tgtattgatt tagaaaagga tcgtttaaaa aaaaaaaaaa aaaa                      4544





<210>  44

<211>  780

<212>  PRT

<213>  Homo sapiens



<400>  44



Met Thr His Thr Arg Arg Lys Ser Leu Pro Met Leu Ser Ser Gly Leu 

1               5                   10                  15      





Thr Gly Arg Arg Glu Pro Leu Gln Met Glu Asp Ser Asn Met Glu Gln 

            20                  25                  30          





Gly Val Glu Gly Val Glu Pro Gly Met Pro Glu Ser Pro Gly His Leu 

        35                  40                  45              





Thr Gly Arg Arg Lys Asn Tyr Pro Leu Arg Lys Arg Pro Leu Val Pro 

    50                  55                  60                  





Glu Lys Pro Lys Ala Cys Lys Val Leu Leu Thr Arg Leu Glu Asn Val 

65                  70                  75                  80  





Ala Gly Pro Arg Ser Ala Asp Glu Ala Asp Glu Leu Pro Pro Asp Leu 

                85                  90                  95      





Pro Lys Pro Pro Ser Pro Ala Pro Ser Ser Glu Asp Pro Gly Leu Ala 

            100                 105                 110         





Gln Pro Arg Lys Arg Arg Leu Ala Ser Leu Asn Ala Glu Ala Leu Asn 

        115                 120                 125             





Asn Leu Leu Leu Glu Arg Glu Asp Thr Ser Ser Leu Ala Gly Thr Arg 

    130                 135                 140                 





Arg Ser Arg Ala Gly Asp Pro His Arg Ser Arg Asp Arg Asp Arg Ala 

145                 150                 155                 160 





Thr Gly Gly Trp Ser Ser Ser Lys Lys Arg Pro Arg Leu Gly Asp Leu 

                165                 170                 175     





Gly Gly Gly Ser Arg Asp Leu Ser Pro Glu Pro Ala Pro Asp Glu Gly 

            180                 185                 190         





Pro Arg Arg Asp Gly Asp Pro Ala Pro Lys Arg Leu Ala Ser Leu Asn 

        195                 200                 205             





Ala Ala Ala Phe Leu Lys Leu Ser Gln Glu Arg Glu Leu Pro Leu Arg 

    210                 215                 220                 





Leu Pro Arg Ala His Ala Glu Val Asp Gly Arg Ser Thr Glu Pro Pro 

225                 230                 235                 240 





Ala Pro Lys Ala Pro Arg Pro Lys Trp Pro Lys Val Asn Gly Lys Asn 

                245                 250                 255     





Tyr Pro Lys Ala Trp Gln Gly Ala Ser Ser Gly Glu Ala Ala Gly Pro 

            260                 265                 270         





Pro Gly Trp Gln Gly Cys Pro Asp Glu Pro Trp Pro Ser Ala Thr Pro 

        275                 280                 285             





Cys Gly Pro Ser Val Gln Pro Ser His Gln Pro Leu Ser Lys Ala Leu 

    290                 295                 300                 





Glu Ser Pro Leu Gly Leu Arg Pro His Leu Pro Leu Leu Met Gly Gly 

305                 310                 315                 320 





Gln Ala Ala Leu Lys Pro Glu Pro Gly Arg Pro Gly Glu Glu Ser Pro 

                325                 330                 335     





Ala Pro Lys Gln Glu Leu His Gln Pro Ser Phe Pro Thr Pro Gln Leu 

            340                 345                 350         





Ser Pro Leu Pro Met Pro Gly Asn Pro Ala Asp Tyr Asn Gly Leu Cys 

        355                 360                 365             





Val Gly Pro Glu Leu Thr Ala Leu Gly Ser Phe Tyr Leu Tyr Cys Gly 

    370                 375                 380                 





Gln Glu Gly Leu Gln Cys Gly Gly Tyr Ser Pro Cys Pro Met Leu Pro 

385                 390                 395                 400 





Glu Gly Lys Leu Ser Pro Val Ala Ala Pro His Glu Glu Gly Leu Leu 

                405                 410                 415     





Leu Ala Pro Ser Ser Val Pro Ser Gly Thr Pro Phe Gln His Pro Pro 

            420                 425                 430         





Trp Gly Ser Ser Arg Tyr Cys Ser Ser Glu Asp Thr Gly Val Asn Gly 

        435                 440                 445             





Tyr Ser Ile Cys Gly Val Leu Pro Leu Ser Val Thr His Ala Gly Thr 

    450                 455                 460                 





Thr Cys Gly Gly Cys Pro Tyr Lys Met Pro Phe Ala Ala Glu Gly Cys 

465                 470                 475                 480 





Arg Ser Leu Gly Gln Leu Glu Phe Pro Leu Pro Glu Ala Gly His Pro 

                485                 490                 495     





Ala Ser Pro Ala His Pro Leu Leu Gly Cys Pro Val Pro Ser Val Pro 

            500                 505                 510         





Pro Ala Ala Glu Pro Val Pro His Leu Gln Thr Pro Thr Ser Glu Pro 

        515                 520                 525             





Gln Thr Val Ala Arg Ala Cys Pro Gln Ser Ala Lys Pro Pro Ser Gly 

    530                 535                 540                 





Ser Lys Ser Gly Leu Arg Thr Gly Ser Ser Cys Arg His Thr Ala Arg 

545                 550                 555                 560 





Ser Lys Ala Ala Arg Arg Pro Ser His Pro Lys Gln Pro Arg Val Gln 

                565                 570                 575     





Arg Pro Arg Pro Arg Arg Arg Arg Arg Arg Arg Thr Asn Gly Trp Val 

            580                 585                 590         





Pro Val Gly Ala Ala Cys Glu Lys Ala Val Tyr Val Leu Asp Glu Pro 

        595                 600                 605             





Glu Pro Ala Ile Arg Lys Ser Tyr Gln Ala Val Glu Arg His Gly Glu 

    610                 615                 620                 





Thr Ile Arg Val Arg Asp Thr Val Leu Leu Lys Ser Gly Pro Arg Lys 

625                 630                 635                 640 





Thr Ser Thr Pro Tyr Val Ala Lys Ile Ser Ala Leu Trp Glu Asn Pro 

                645                 650                 655     





Glu Ser Gly Glu Leu Met Met Ser Leu Leu Trp Tyr Tyr Arg Pro Glu 

            660                 665                 670         





His Leu Gln Gly Gly Arg Ser Pro Ser Met His Glu Pro Leu Gln Asn 

        675                 680                 685             





Glu Val Phe Ala Ser Arg His Gln Asp Gln Asn Ser Val Ala Cys Ile 

    690                 695                 700                 





Glu Glu Lys Cys Tyr Val Leu Thr Phe Ala Glu Tyr Cys Arg Phe Cys 

705                 710                 715                 720 





Ala Met Ala Lys Arg Arg Gly Glu Gly Leu Pro Ser Arg Lys Thr Ala 

                725                 730                 735     





Leu Val Pro Pro Ser Ala Asp Tyr Ser Thr Pro Pro His Arg Thr Val 

            740                 745                 750         





Pro Glu Asp Thr Asp Pro Glu Leu Val Phe Leu Cys Arg His Val Tyr 

        755                 760                 765             





Asp Phe Arg His Gly Arg Ile Leu Lys Asn Pro Gln 

    770                 775                 780 





<210>  45

<211>  1821

<212>  DNA

<213>  Homo sapiens



<400>  45

ctcagcgtag ggctgtgagg gcgcagtcca ccgccaggag ccttccggtt tctgcgcggt       60



gcgcgacctc gtcccgaagc ctggggatac accctctcga gagcccgctg tcgccctccg      120



ttaaggtcga acccctcaca gttgctgtgg gcaactccag cccaacattc cctcgctctg      180



gttctcgccc cattgggaaa ctcggcccca cgcttcccac ttttctggat gaggtgtccc      240



ctttctcccc actaaaatgt caaataacct acggagggtc ttcctgaaac ccgcagagga      300



aaattcaggc aacgcctcgc gttgatccat aatgagatgg catcaacatc agataaaggt      360



gcccaaggaa gaaatgacaa gaaagattct caaggaagaa gtaataaggc attacatctg      420



aagagtgatg ctgaatttaa aaagatattt ggccttacta aggatttgag agtgtgcctt      480



actcgaattc ctgaccattt gacctctgga gaaggtttcg attcctttag cagtttggta      540



aagagtggta cttacaaaga gacagagttt atggtgaagg aaggagagag aaaacagcag      600



aattttgata agaaaagaaa agcaaaaact aataagaaga tggatcacat aaagaagaga      660



aaaacagaga atgcttataa cgcaatcata aatggggaag ctaatgtcac cggttcccaa      720



ctcctaagca gtattttacc aacttcagat gtgtcacaac ataacattct cacgagtcac      780



agcaaaacca gacaagaaaa gagaactgag atggaatact atacccatga gaagcaagag      840



aaaggcactt tgaattcaaa tgcagcttat gaacaaagtc atttcttcaa taaaaattat      900



accgaagata ttttcccagt gacaccaccg gagttagaag aaaccattcg agatgaaaaa      960



ataagaagac ttaagcaggt gctgagagag aaagaagcag ctcttgaaga aatgcgtaag     1020



aagatgcacc aaaaataaaa tctcctgtaa agacttcagt gaaatagctg ttttttaaaa     1080



tatacttcag cattaataag ttaattgtag gtgtgttctg aaagtgtctt tgaatatgaa     1140



gcttgttttt tcatcagtcg attgtacaac tttaaggaat acagaaaagg ttgattcaca     1200



tatgacttgt gaataattta catggggtat ctataccttt gtcttagata cctttttttg     1260



gaaggataaa ttttatattt ttctattatt ttaactagaa ttctccaagt ttgaatattt     1320



gggcagggtt tttgttattg tttgtatctt tacctaaatt gctcaggcat tattccagca     1380



gtagatagtg actgtgtatt actgaaattt tacaattcaa gagaggaaat cagctccaaa     1440



cttagctttt ccagtggatt tgtatatgta cttgctttat ctctttaccc ttaaaatgat     1500



gataccttgt attcaccatt gtttttttta atgtcgtgaa ataatatgta ttatggcaac     1560



attatttaaa cattcaaaca tttctcaaga atgagcaaca tttgtaactt tacaatgtaa     1620



ttttatataa tccaaaggta ttttagaatt caggccattt gatgttttgt ttgcttatag     1680



tgatgtgttc ccaggcaaat gctgcttttt ttttttttgg gactatgtac atacgttact     1740



gagattgtgt aaaaagtaga tcctgaacag ttatcacatt taatatttct taaactgtaa     1800



aagtgtaaaa aaaaaaaaaa a                                               1821





<210>  46

<211>  233

<212>  PRT

<213>  Homo sapiens



<400>  46



Met Ala Ser Thr Ser Asp Lys Gly Ala Gln Gly Arg Asn Asp Lys Lys 

1               5                   10                  15      





Asp Ser Gln Gly Arg Ser Asn Lys Ala Leu His Leu Lys Ser Asp Ala 

            20                  25                  30          





Glu Phe Lys Lys Ile Phe Gly Leu Thr Lys Asp Leu Arg Val Cys Leu 

        35                  40                  45              





Thr Arg Ile Pro Asp His Leu Thr Ser Gly Glu Gly Phe Asp Ser Phe 

    50                  55                  60                  





Ser Ser Leu Val Lys Ser Gly Thr Tyr Lys Glu Thr Glu Phe Met Val 

65                  70                  75                  80  





Lys Glu Gly Glu Arg Lys Gln Gln Asn Phe Asp Lys Lys Arg Lys Ala 

                85                  90                  95      





Lys Thr Asn Lys Lys Met Asp His Ile Lys Lys Arg Lys Thr Glu Asn 

            100                 105                 110         





Ala Tyr Asn Ala Ile Ile Asn Gly Glu Ala Asn Val Thr Gly Ser Gln 

        115                 120                 125             





Leu Leu Ser Ser Ile Leu Pro Thr Ser Asp Val Ser Gln His Asn Ile 

    130                 135                 140                 





Leu Thr Ser His Ser Lys Thr Arg Gln Glu Lys Arg Thr Glu Met Glu 

145                 150                 155                 160 





Tyr Tyr Thr His Glu Lys Gln Glu Lys Gly Thr Leu Asn Ser Asn Ala 

                165                 170                 175     





Ala Tyr Glu Gln Ser His Phe Phe Asn Lys Asn Tyr Thr Glu Asp Ile 

            180                 185                 190         





Phe Pro Val Thr Pro Pro Glu Leu Glu Glu Thr Ile Arg Asp Glu Lys 

        195                 200                 205             





Ile Arg Arg Leu Lys Gln Val Leu Arg Glu Lys Glu Ala Ala Leu Glu 

    210                 215                 220                 





Glu Met Arg Lys Lys Met His Gln Lys 

225                 230             





<210>  47

<211>  3349

<212>  DNA

<213>  Homo sapiens



<400>  47

ctcagcgtag ggctgtgagg gcgcagtcca ccgccaggag ccttccggtt tctgcgcggt       60



gcgcgacctc gtcccgaagc ctggggatac accctctcga gagcccgctg tcgccctccg      120



ttaaggtcga acccctcaca gttgctgtgg gcaactccag cccaacattc cctcgctctg      180



gttctcgccc cattgggaaa ctcggcccca cgcttcccac ttttctggat gaggtgtccc      240



ctttctcccc actaaaatgt caaataacct acggagggtc ttcctgaaac ccgcagagga      300



aaattcaggc aacgcctcgc gttgtgtttc aggctgcatg taccaagtag ttcagacgat      360



tggctcggat ggaaaaaatc ttctgcaatt acttccaatt cctaagtctt ctggaaatct      420



tataccacta gttcaatctt cagtcatgtc tgatgctttg aaagggaata caggaaaacc      480



agttcaagtt acttttcaga ctcagatttc cagctcttcc acaagtgcat cagttcaatt      540



gcccattttt cagccagcca gttcttcaaa ctattttctt acaagaacag tagatacatc      600



agaaaaaggt agagttactt ctgtgggaac tggaaatttt tcttcatcag tttctaaagt      660



tcagagtcat ggtgtgaaaa ttgatggact caccatgcaa acatttgctg ttcctccctc      720



aacacaaaaa gactcatctt ttattgtagt taatacccag agtcttccag tgactgtgaa      780



gtctccagtt ttgccttctg ggcatcattt acagattcca gcccatgctg aagtgaaatc      840



tgtaccagcg tcatcattgc ctccttcagt gcagcaaaag atacttgcaa ctgccaccac      900



cagtacctca ggaatggttg aggcctccca aatgccaacc gttatttatg tatctcctgt      960



aaatacagtg aaaaatgtag ttaccaagaa ctttcaaaac atttacccaa aacctgttac     1020



agaaatagca aagccagtaa tactaaatac cacacaaatt ccaaagaatg ttgctacaga     1080



gacacaattg aaaggtggtc agcattctca agctgctcca gtgaaatgga ttttccaaga     1140



taatctacag ccttttacgc catctcttgt tcctgttaag tcttcaaata atgtggcttc     1200



aaagatttta aaaacttttg tagataggaa aaatttggga gataatacta taaatatgcc     1260



accattgagt accatcgatc ctagtgggac gcgatccaaa aatatgccta ttaaagataa     1320



tgctttggtt atgtttaatg ggaaagtcta tctgttggct aaaaagggga cagatgttct     1380



gccatcacaa attgaccaac agaattctgt ttctcctgat actccagtaa gaaaagacac     1440



gttacagaca gtgagttcaa gtccagtcac agaaatatcc agagaggttg taaatattgt     1500



tttggctaaa agtaaatctt cccagatgga gacaaaatca ctttccaata cccagcttgc     1560



ttccatggcc aatctaaggg cagagaagaa taaagtggag aaaccatctc cttctaccac     1620



aaatccacat atgaaccaat ccagtaacta cttaaaacag agtaagactt tattcacaaa     1680



tccaatcttt ccagttggat ttagtacagg acacaatgcc cccagaaaag taacagccgt     1740



catttatgct agaaaaggaa gtgtcctcca gagcatagag aaaataagtt cctctgttga     1800



tgcaacaact gttacttcac aacagtgtgt tttcagagac caagaaccaa agatccataa     1860



tgagatggca tcaacatcag ataaaggtgc ccaaggaaga aatgacaaga aagattctca     1920



aggaagaagt aataaggcat tacatctgaa gagtgatgct gaatttaaaa agatatttgg     1980



ccttactaag gatttgagag tgtgccttac tcgaattcct gaccatttga cctctggaga     2040



aggtttcgat tcctttagca gtttggtaaa gagtggtact tacaaagaga cagagtttat     2100



ggtgaaggaa ggagagagaa aacagcagaa ttttgataag aaaagaaaag caaaaactaa     2160



taagaagatg gatcacataa agaagagaaa aacagagaat gcttataacg caatcataaa     2220



tggggaagct aatgtcaccg gttcccaact cctaagcagt attttaccaa cttcagatgt     2280



gtcacaacat aacattctca cgagtcacag caaaaccaga caagaaaaga gaactgagat     2340



ggaatactat acccatgaga agcaagagaa aggcactttg aattcaaatg cagcttatga     2400



acaaagtcat ttcttcaata aaaattatac cgaagatatt ttcccagtga caccaccgga     2460



gttagaagaa accattcgag atgaaaaaat aagaagactt aagcaggtgc tgagagagaa     2520



agaagcagct cttgaagaaa tgcgtaagaa gatgcaccaa aaataaaatc tcctgtaaag     2580



acttcagtga aatagctgtt ttttaaaata tacttcagca ttaataagtt aattgtaggt     2640



gtgttctgaa agtgtctttg aatatgaagc ttgttttttc atcagtcgat tgtacaactt     2700



taaggaatac agaaaaggtt gattcacata tgacttgtga ataatttaca tggggtatct     2760



atacctttgt cttagatacc tttttttgga aggataaatt ttatattttt ctattatttt     2820



aactagaatt ctccaagttt gaatatttgg gcagggtttt tgttattgtt tgtatcttta     2880



cctaaattgc tcaggcatta ttccagcagt agatagtgac tgtgtattac tgaaatttta     2940



caattcaaga gaggaaatca gctccaaact tagcttttcc agtggatttg tatatgtact     3000



tgctttatct ctttaccctt aaaatgatga taccttgtat tcaccattgt tttttttaat     3060



gtcgtgaaat aatatgtatt atggcaacat tatttaaaca ttcaaacatt tctcaagaat     3120



gagcaacatt tgtaacttta caatgtaatt ttatataatc caaaggtatt ttagaattca     3180



ggccatttga tgttttgttt gcttatagtg atgtgttccc aggcaaatgc tgcttttttt     3240



ttttttggga ctatgtacat acgttactga gattgtgtaa aaagtagatc ctgaacagtt     3300



atcacattta atatttctta aactgtaaaa gtgtaaaaaa aaaaaaaaa                 3349





<210>  48

<211>  769

<212>  PRT

<213>  Homo sapiens



<400>  48



Met Ser Asn Asn Leu Arg Arg Val Phe Leu Lys Pro Ala Glu Glu Asn 

1               5                   10                  15      





Ser Gly Asn Ala Ser Arg Cys Val Ser Gly Cys Met Tyr Gln Val Val 

            20                  25                  30          





Gln Thr Ile Gly Ser Asp Gly Lys Asn Leu Leu Gln Leu Leu Pro Ile 

        35                  40                  45              





Pro Lys Ser Ser Gly Asn Leu Ile Pro Leu Val Gln Ser Ser Val Met 

    50                  55                  60                  





Ser Asp Ala Leu Lys Gly Asn Thr Gly Lys Pro Val Gln Val Thr Phe 

65                  70                  75                  80  





Gln Thr Gln Ile Ser Ser Ser Ser Thr Ser Ala Ser Val Gln Leu Pro 

                85                  90                  95      





Ile Phe Gln Pro Ala Ser Ser Ser Asn Tyr Phe Leu Thr Arg Thr Val 

            100                 105                 110         





Asp Thr Ser Glu Lys Gly Arg Val Thr Ser Val Gly Thr Gly Asn Phe 

        115                 120                 125             





Ser Ser Ser Val Ser Lys Val Gln Ser His Gly Val Lys Ile Asp Gly 

    130                 135                 140                 





Leu Thr Met Gln Thr Phe Ala Val Pro Pro Ser Thr Gln Lys Asp Ser 

145                 150                 155                 160 





Ser Phe Ile Val Val Asn Thr Gln Ser Leu Pro Val Thr Val Lys Ser 

                165                 170                 175     





Pro Val Leu Pro Ser Gly His His Leu Gln Ile Pro Ala His Ala Glu 

            180                 185                 190         





Val Lys Ser Val Pro Ala Ser Ser Leu Pro Pro Ser Val Gln Gln Lys 

        195                 200                 205             





Ile Leu Ala Thr Ala Thr Thr Ser Thr Ser Gly Met Val Glu Ala Ser 

    210                 215                 220                 





Gln Met Pro Thr Val Ile Tyr Val Ser Pro Val Asn Thr Val Lys Asn 

225                 230                 235                 240 





Val Val Thr Lys Asn Phe Gln Asn Ile Tyr Pro Lys Pro Val Thr Glu 

                245                 250                 255     





Ile Ala Lys Pro Val Ile Leu Asn Thr Thr Gln Ile Pro Lys Asn Val 

            260                 265                 270         





Ala Thr Glu Thr Gln Leu Lys Gly Gly Gln His Ser Gln Ala Ala Pro 

        275                 280                 285             





Val Lys Trp Ile Phe Gln Asp Asn Leu Gln Pro Phe Thr Pro Ser Leu 

    290                 295                 300                 





Val Pro Val Lys Ser Ser Asn Asn Val Ala Ser Lys Ile Leu Lys Thr 

305                 310                 315                 320 





Phe Val Asp Arg Lys Asn Leu Gly Asp Asn Thr Ile Asn Met Pro Pro 

                325                 330                 335     





Leu Ser Thr Ile Asp Pro Ser Gly Thr Arg Ser Lys Asn Met Pro Ile 

            340                 345                 350         





Lys Asp Asn Ala Leu Val Met Phe Asn Gly Lys Val Tyr Leu Leu Ala 

        355                 360                 365             





Lys Lys Gly Thr Asp Val Leu Pro Ser Gln Ile Asp Gln Gln Asn Ser 

    370                 375                 380                 





Val Ser Pro Asp Thr Pro Val Arg Lys Asp Thr Leu Gln Thr Val Ser 

385                 390                 395                 400 





Ser Ser Pro Val Thr Glu Ile Ser Arg Glu Val Val Asn Ile Val Leu 

                405                 410                 415     





Ala Lys Ser Lys Ser Ser Gln Met Glu Thr Lys Ser Leu Ser Asn Thr 

            420                 425                 430         





Gln Leu Ala Ser Met Ala Asn Leu Arg Ala Glu Lys Asn Lys Val Glu 

        435                 440                 445             





Lys Pro Ser Pro Ser Thr Thr Asn Pro His Met Asn Gln Ser Ser Asn 

    450                 455                 460                 





Tyr Leu Lys Gln Ser Lys Thr Leu Phe Thr Asn Pro Ile Phe Pro Val 

465                 470                 475                 480 





Gly Phe Ser Thr Gly His Asn Ala Pro Arg Lys Val Thr Ala Val Ile 

                485                 490                 495     





Tyr Ala Arg Lys Gly Ser Val Leu Gln Ser Ile Glu Lys Ile Ser Ser 

            500                 505                 510         





Ser Val Asp Ala Thr Thr Val Thr Ser Gln Gln Cys Val Phe Arg Asp 

        515                 520                 525             





Gln Glu Pro Lys Ile His Asn Glu Met Ala Ser Thr Ser Asp Lys Gly 

    530                 535                 540                 





Ala Gln Gly Arg Asn Asp Lys Lys Asp Ser Gln Gly Arg Ser Asn Lys 

545                 550                 555                 560 





Ala Leu His Leu Lys Ser Asp Ala Glu Phe Lys Lys Ile Phe Gly Leu 

                565                 570                 575     





Thr Lys Asp Leu Arg Val Cys Leu Thr Arg Ile Pro Asp His Leu Thr 

            580                 585                 590         





Ser Gly Glu Gly Phe Asp Ser Phe Ser Ser Leu Val Lys Ser Gly Thr 

        595                 600                 605             





Tyr Lys Glu Thr Glu Phe Met Val Lys Glu Gly Glu Arg Lys Gln Gln 

    610                 615                 620                 





Asn Phe Asp Lys Lys Arg Lys Ala Lys Thr Asn Lys Lys Met Asp His 

625                 630                 635                 640 





Ile Lys Lys Arg Lys Thr Glu Asn Ala Tyr Asn Ala Ile Ile Asn Gly 

                645                 650                 655     





Glu Ala Asn Val Thr Gly Ser Gln Leu Leu Ser Ser Ile Leu Pro Thr 

            660                 665                 670         





Ser Asp Val Ser Gln His Asn Ile Leu Thr Ser His Ser Lys Thr Arg 

        675                 680                 685             





Gln Glu Lys Arg Thr Glu Met Glu Tyr Tyr Thr His Glu Lys Gln Glu 

    690                 695                 700                 





Lys Gly Thr Leu Asn Ser Asn Ala Ala Tyr Glu Gln Ser His Phe Phe 

705                 710                 715                 720 





Asn Lys Asn Tyr Thr Glu Asp Ile Phe Pro Val Thr Pro Pro Glu Leu 

                725                 730                 735     





Glu Glu Thr Ile Arg Asp Glu Lys Ile Arg Arg Leu Lys Gln Val Leu 

            740                 745                 750         





Arg Glu Lys Glu Ala Ala Leu Glu Glu Met Arg Lys Lys Met His Gln 

        755                 760                 765             





Lys 

    





<210>  49

<211>  9404

<212>  DNA

<213>  Homo sapiens



<400>  49

atggaggttc cagaacccac ctgccctgcc cctcctgcga gggaccagcc agctcccact       60



cctggccctc caggggcccc aggtggccag gcctcacctc acctgaccct gggccctgtc      120



cttctgccgc cagagcaggg cctggccccc cccactgtgt tcctgaaggc cctgcccatc      180



ccactgtacc acacggtgcc tcccgggggc ctccagcccc gcgccccgct agtgacgggc      240



agcctagatg ggggcaacgt gcccttcata ctcagccctg tgctgcagcc tgaagggcct      300



ggccccaccc aggtggggaa gccggcggcc cctacgctga cggtgaacat cgtgggcact      360



ctgcctgtcc tgtcgccggg cctgggcccc acgctgggca gcccaggcaa ggtgcggaat      420



gcgggcaagt acctgtgtcc gcactgtggt cgcgactgcc tgaagcccag tgttctagag      480



aagcacatcc ggtcccacac gggtgagagg cccttcccgt gtgccacctg cggcatcgcc      540



tttaagaccc agagcaatct ctacaagcac aggcggacgc agacgcacct caacaactcc      600



cggctgtcct cagagtccga gggcgccggg ggcggcctcc tggaggaagg ggacaaggcc      660



ggagagcccc ccagaccaga gggcaggggc gagagcaggt gccaggggat gcacgaaggc      720



gcctcggaga gacccctttc tccgggtgcc cacgtgcccc tacttgccaa gaacctggat      780



gtgaggaccg aagctgctcc ctgtccaggg tccgcatttg ccgacagaga ggctccttgg      840



gactctgccc ccatggcgtc acctgggctc ccagcggcca gcacacaacc ctggcgtaag      900



ttgccagagc agaagtcgcc gaccgccggg aagccgtgcg ccctgcagcg gcagcaggcg      960



acggcagcgg agaagccctg ggatgccaag gcccccgagg gccggctgcg gaagtgtgag     1020



agcaccgact cggggtacct gtcgcgctcc gacagcgcgg agcagccgca tgcgccctgc     1080



agccccctgc acagcctttc ggagcacagc gccgagtccg agggggaggg cggcccgggc     1140



ccggggccag gggtcgcagg ggccgagccc ggggcgcgag aagccggcct ggagctggag     1200



aagaagcggc tggaggagcg catcgcccag ctcatctccc acaaccaggc ggtggtggac     1260



gatgcccagc tggacaacgt gcggccccgg aagaccgggc tgtccaaaca gggcagcatc     1320



gacctgccca cgccctacac ctacaaggac tccttccact ttgacatccg cgcgctggag     1380



ccaggccgta ggagggcccc gggccccgtg cgctccacct ggacgccccc agacaagtct     1440



cggcccctct tcttccactc cgtccccact cagctctcca ccaccgtgga atgtgtcccc     1500



gtcaccagga gcaactcgct gcccttcgtc gagggctcca ggacgtggct ggagcccagg     1560



gagccccggg acccctggtc caggacgcag aagcctctga gccccaggcc cggcccagcc     1620



cgcctgggct gccgctcggg actaagctcg actgacgttc ccagtgggca tccccgggcc     1680



ctggtcagac aggccgcggt ggaggacctg ccaggcaccc ccattggcga tgccctggtg     1740



cccgcagagg acacagacgc aaagagaact gctgcgcggg aggccatggc cggcaagggc     1800



agagcgggcg gcaggaagtg cggccagaga aggctgaaga tgttctccca ggagaagtgg     1860



caggtgtacg gggatgagac gttcaaaagg atctaccaga aaatgaaagc cagtccccat     1920



ggaggcaaga aagccaggga ggtgggaatg ggcagtgggg cagaactggg ctttcctctg     1980



cagaaagagg cagcagggag ctcaggcaca gtccccaccc aagacaggag gacccctgtc     2040



catgaggaca tatccgcagg ggcaacgcca gagccttggg gaaatccacc agccctggag     2100



gcctccttgg tgactgaacc cactaagcat ggggagacgg tggccaggag aggagacagt     2160



gaccgaccca gggtggaaga ggctgtgtca tcccctgcac tgggtggcag agacagtccc     2220



tgttcaggca gtaggagccc cctggtctct ccaaatggga ggctggaact ggggtggcag     2280



atgcccccag cacctggccc cctcaaaggg ggtgatgtag aggctcccag gccagtttgg     2340



ccggacccca agctggaagg aggtgcccga ggtgtggggg atgttcagga gacctgcctg     2400



tgggcccaga ctgtcctgag atggcccagc aggggctcag gggaggacaa gctcccctca     2460



gagaggaaga agctgaaagt ggaggacctg cacagctgga agcaaccaga gcctgtgagc     2520



gcagagaccc caggtgggcc cacgcagcct gcctctttgt catcccagaa gcaggatgcc     2580



gatcccgggg aggtgccagg gggctcaaag gagagtgcca ggcaggtggg cgagcctctg     2640



gagtcctctg gagcctcctt ggctgctgct tctgttgccc tgaagagggt ggggccaagg     2700



gacaaggcta ccccactgca tcctgcagcc ccagcccccg cagagcaccc ctcgctggcc     2760



accccacctc aggctcctag agtgctctct gccctggcag ataatgcctt ttcccccaag     2820



tacctcctca ggttacctca ggcagagacc cccttaccac tgcccattcc ctggggacca     2880



aggcacagcc aggactctct ctgcagcagt gggtggcctg aagaacgggc atcatttgtt     2940



gggtcaggac tggggacccc tctttctccc agcccagcct caggcccctc cccaggtgag     3000



gcggacagca tcctggagga ccccagctgt tccaggccac aggatgggag aaaaggggca     3060



cagttggggg gggacaaggg ggacaggatg gccactagca ggccagcagc cagggagttg     3120



cccatctcag caccaggggc tcccagggag gctacctcct ccccgcccac tccaacgtgt     3180



gaggcacact tagttcagga catggagggt gacagccacc gtatccatcg cctctgcatg     3240



ggcagcactt tggcaagggc caggctctct ggggatgtcc tgaatccctg ggtacccaac     3300



tgggagctgg gggagcctcc tgggaatgcc ccagaagatc cttcttcagg gcccctggtg     3360



ggccccgacc cgtgttcccc cctccagcct ggctccttcc tcactgccct cactcggcct     3420



cagggtgtgc ccccaggctg gccagagctg gccttgtctt cccactcagg gacgtcccgg     3480



agccacagca cccgcagtcc ccacagcacc caaaacccct ttccctcact gaaggctgag     3540



ccgcggctca cgtggtgttg cctgagccgc agtgtccctc tgcccgcgga gcagaaggca     3600



aaggcggcat ctgtgtactt ggcggtgcac tttcctggta gcagcctccg agatgagggt     3660



cccaatggcc ctcctgggag caatggagga tggacctgga caagccctgg agaaggaggg     3720



ccggcgcaga tgtccaagtt ctcctaccca acagtcccag gggtgatgcc ccagcaccag     3780



gtgtctgagc cagaatggaa gaaaggcctg ccttggaggg caaagatgtc tcgtgggaac     3840



agcaagcaga gaaaactgaa gatcaaccct aaaaggtaca aagggaattt cttgcagagc     3900



tgtgttcagc tgagagccag tagacttcgc acaccaacct gggtgcgaag aagaagccgc     3960



caccctcccg cacttgaggg actgaagcca tgcaggaccc ctgggcagac ctcttcagaa     4020



atagcaggtc tgaatctgca agaggagcca tcttgtgcca cctcagaatc acctccttgt     4080



tgtgggaagg aagagaagaa ggaaggtgac tgcagacaaa ccttaggaac cctctctctt     4140



ggtacaagtt caagaattgt cagggaaatg gacaaacgaa ctgtgaagga tatttctcca     4200



tctgctggtg agcatggtga ctgtactact cacagcactg ctgccacatc aggattatct     4260



ctgcaatctg acacctgcct ggcagtggtt aatgacgtgc ctctaccccc tggcaaaggt     4320



cttgaccttg ggttgctgga gactcagctg ctggcctccc aggattcagt ctcaacagat     4380



cccaaaccat acatcttctc agatgctcaa aggccttctt cctttgggtc caaaggaact     4440



tttccccacc atgacattgc tacctctgtg gctgccgttt gtatttctct gccagtgaga     4500



acagatcaca tagcccagga aattcacagt gctgaatcac gagaccacag ccagactgca     4560



gggaggactc tgacatcaag ctccccagac agcaaagtca cagaagaggg cagagcacag     4620



accctcttgc cagggagacc ttcatctgga caaagaattt cagattcggt tccactggag     4680



tcaactgaaa aaactcatct tgaaatacca gcttcaggac caagttcagc tagttcacac     4740



cacaaggaag ggagacacaa gacgtttttt ccttccagag gccagtatgg gtgtggggaa     4800



atgactgtcc cctgcccctc tttaggaagt gacggtagga aacgtcaggt atctggatta     4860



atcactcgga aagattctgt ggttccttct aagccagagc agcccataga aattcctgaa     4920



gccccttcta aatccctcaa gaagaggagt ctggaaggaa tgagaaagca aactcgagta     4980



gagttcagtg acaccagcag cgacgatgaa gaccgattag ttatagaaat atgaagcttc     5040



cagagaaaca tggtgtctgg tcaaaaagac tgttgacgct tcacaagtaa atgttgtcag     5100



gctggcggaa gaactaaact ctatctgtga aacacctaca gattaggaaa gccattttga     5160



gttatttaca agccaactcc aaccaacttc tgacccccaa ctcagccgca gcgttcccca     5220



gctccccttg ggagtgctct gctcatcttc aaatggtgcc aggcagggca gacatggcaa     5280



ggaagcaaac tctgcaaatg gtcaacgtgc acagtgactg ggccttgact cccagcctcg     5340



tcttctgcac ctgtccccca ctgcctctct gcaatcaaat ggcactaacc aagaaagcca     5400



ccatcaacac atttctccac aagtggaccc cacacagtcg aggcaactgg ctttctccat     5460



tagtaaactg aggatttgct tccaaggtgg agagcacact tgggataatt ggagtagctt     5520



gacaaagaga cgggggtgtg aactgggcac aaagatactt ctgttcattt tggagacaaa     5580



attcagatac attaaaaaac tgaagcttgt tcagagtaat tcacgtcctt ggtggagttg     5640



taaatacact tcaaaatgcc tatgatccgg tgacatgctg attactttta aatgttgcac     5700



aaatggtcaa tgcttattta tggtcagatg atgcaagcac atgctcttgt gcctggtgcg     5760



tttgctgtgg agatctctga gactgtcggt ttttctagtt cttgcaaagg aacggtgtta     5820



aaagttaata gaactgtctc tctgtaatga gtcatttttt gagagggaaa aattcactta     5880



ttttcctctg attcttcttg tcatattgtg ctctgagcaa tttcaattag agggttacat     5940



tttagtaatc tgtacagctt caactgatgc ctgctcgtcg tgacgggagc cttttagatt     6000



tccttcagaa gcttcaagga tacaaaacta attggagttt tgacgctgtt ttacatctcg     6060



gtaattttat tttcggggct tagtgttact ttgctgtcaa attaaatcag cctctgtatt     6120



gtgcacgtca gaactgcaca gagaaaattc cccagtattc caagccggtg cgcccctgtg     6180



cagaagaaaa cagatctacg tcagccagcc cggggggcaa agcctcagtt ccactgcctt     6240



cctctccctc tccttccacg ggagaggaga aacttaaaga ggtttacatt gctgcatttc     6300



aataaaattt tatacttgct tttggtatga ttttgtacaa tttgaaattt gtagctgagc     6360



tcttttggtg taactttgat gtaatgatgt tcatatgaca tcttgtactt cagagacaca     6420



gcagcaatgc agagcatctc acacatgtga atacacttca gtcagtctgt gcctgtgact     6480



aagtatggtc aaatttcaag tatcttcatg tgaattttcc aattttggtg tttttcatag     6540



aaaacttcaa tgccagacca gcttccctgg ttacttagca tatatttgtg accatttcat     6600



atgcactcat aaatatccaa ggatttcagg cccagccaag aaaaacataa gaagggaggt     6660



aaaaaggatg ttggacattg acttagtgta ctttttaaac ccaacaaaag cgatgtggtg     6720



attatctccc ttttcgaagg attcatgcca ctgtaatgag agaggcagtg taggcaaatg     6780



gtctgagcct tggatggaga ttgaagtcct gactttagct gggaaatctt ggttaagagt     6840



ctttctgtac cttagtttcc ctaagtgaga ataagagagt tggacaagac gaatgtatct     6900



ccaggttcca atttttctga gaatggttga tagagaagct gctctctcct taaaatgcat     6960



ggactcaatg gcttgaagat attccccatg gggaaccatt gccacggagg ccttgcatgc     7020



aagaagtttg ggtggggaca gtgaggaact gaaacacaag caccttccac caattattgc     7080



tgtgaagaac ctgagcctga agaagctcca tctaattttt tccccagagt tccagatttt     7140



agggtgcaat catccagcct atacatgtgg ctcatagttc aaaaaattaa aagcaaaacc     7200



agaactctcc agtaggaatg gagaaaacct atctgtaggc tgaactggct cctttgtctt     7260



aggaggcact ggtcagggga aaaaagctgt cttccagacc cctcctttct gggtggctac     7320



tgtggaatca acggggtcac tggctgtaaa tcagtaagtc atagctccaa acagcaccaa     7380



cttcaggatg atggtggaag ctctgtccct ataggagcca ccgttgccag ctgtcacatc     7440



ccaacctagg tcaaatatgg cggaatattg atttcgtctc taactccctg tatctcttac     7500



aaaggtaaag caggtagcga agccaccttg cttccctggt ctttgcctag tggctggcaa     7560



tgtttacaag tgtaccttac tttatatcaa catgaatttg tgaaaaagct gtatgtcaat     7620



ggatttttta aaaattaaaa atgtattttg aatgacccta agggagctgg ctctttaaaa     7680



gcatcctaag gtaaagattt tttttaaatg aagaatcttt ttataaagca atgaacaatc     7740



tctgatttta taaatcttaa ttttcctatg ggttttctta aagtgaaata caattataag     7800



aatacatttt aagggtaaca ttaacaacct agaacccagt ttgggttact aaaaataaaa     7860



tgtcagtatt atcaattgat aactaccaca gttttatact ctgcaagtgt gtactgcatg     7920



atggttaagg aaaaacaaat ttattttaga acaaagcaaa ccagagttta aagatcaggg     7980



atttccttct ttccccagtg ctaattttcc cagtgttaat tttattatat ctttaggtaa     8040



gggtcttaac caactgatgc ctcagtttct tccacagaga atagttagag ggatgctgtc     8100



atgaactaag ggaagggcac tgaatttttt tttgccaata tcaaaagtga catttcccca     8160



tgatgttcaa gactcaccag gtttctctct ccacctgtac ctacacccag ctagatcttg     8220



tcgttaaaga tgtatggagg gaagaggttt caatccttcc ctccttggca acctacattg     8280



ttaagtgact caaagtcatg tgatttttgg tggacaactg gaatcctcct tcttgtaaaa     8340



cacattgaaa aacagctcat ctctcctgtt aggcttaacc cttgagattt gagacaaagc     8400



taataatccc ctttggttca catctcacag taaccaggag aacctatggt tcatttgcca     8460



agtgattaaa aaaaaagatg gaggagggtg tctctgaatt ttaatggaaa cactgccaat     8520



agcatggtgg gtaacctagg gcaagacaga ctttttcttc ctgaaatcac tcttctaaag     8580



ctgagaccgg aagaggaacc ttgcagaagt gcactgtgac cacagttctt ggcatgaaag     8640



ataaacaatt tgcagtctca tgccaaaaag tatttccttg catttacatt cattacttag     8700



aatgatcaca ttattcattt ttttccccag cacagaaatt tgcattttgc acagaatttg     8760



cctggtgcag cagatcttta tagttatgga aactgtcatc attatcggaa tgtgctgctg     8820



ctcaactccc cagacataat ttaatatggt gaggagaata tgacctgcct ggctctatgg     8880



gtgatcatat ttctactgct gcagcaagct gggcttgtgt atttttcctc acttcagttg     8940



ttcttcccat agttcatgta gggaggcact ttggcttttg aaacactaca tttctcaata     9000



tttaagcaca atttattgtc cttatttttc agaacccatt aaatataagg gtcagaacct     9060



agaaaatctt atgtgctgga tttctaccct gtatgattct tttcatccat gctttgcact     9120



tacgtaggaa tatacataat ttggtctgaa gaagtatagg aacagttgag cacattactt     9180



caccactgga agaataggaa ccagggaaaa acatcagcct ctgccacttg gagcactaga     9240



ggatgacgga atgtcttgta tatgcggtca actgttcagg atttactact caattggttg     9300



ttcacaatca gggaaatgat tggcttcttg gttgtttgtt gaactttctt tctttatatg     9360



gttaaattat tttgttttga taaaaataaa acttaaaatg caaa                      9404





<210>  50

<211>  1677

<212>  PRT

<213>  Homo sapiens



<400>  50



Met Glu Val Pro Glu Pro Thr Cys Pro Ala Pro Pro Ala Arg Asp Gln 

1               5                   10                  15      





Pro Ala Pro Thr Pro Gly Pro Pro Gly Ala Pro Gly Gly Gln Ala Ser 

            20                  25                  30          





Pro His Leu Thr Leu Gly Pro Val Leu Leu Pro Pro Glu Gln Gly Leu 

        35                  40                  45              





Ala Pro Pro Thr Val Phe Leu Lys Ala Leu Pro Ile Pro Leu Tyr His 

    50                  55                  60                  





Thr Val Pro Pro Gly Gly Leu Gln Pro Arg Ala Pro Leu Val Thr Gly 

65                  70                  75                  80  





Ser Leu Asp Gly Gly Asn Val Pro Phe Ile Leu Ser Pro Val Leu Gln 

                85                  90                  95      





Pro Glu Gly Pro Gly Pro Thr Gln Val Gly Lys Pro Ala Ala Pro Thr 

            100                 105                 110         





Leu Thr Val Asn Ile Val Gly Thr Leu Pro Val Leu Ser Pro Gly Leu 

        115                 120                 125             





Gly Pro Thr Leu Gly Ser Pro Gly Lys Val Arg Asn Ala Gly Lys Tyr 

    130                 135                 140                 





Leu Cys Pro His Cys Gly Arg Asp Cys Leu Lys Pro Ser Val Leu Glu 

145                 150                 155                 160 





Lys His Ile Arg Ser His Thr Gly Glu Arg Pro Phe Pro Cys Ala Thr 

                165                 170                 175     





Cys Gly Ile Ala Phe Lys Thr Gln Ser Asn Leu Tyr Lys His Arg Arg 

            180                 185                 190         





Thr Gln Thr His Leu Asn Asn Ser Arg Leu Ser Ser Glu Ser Glu Gly 

        195                 200                 205             





Ala Gly Gly Gly Leu Leu Glu Glu Gly Asp Lys Ala Gly Glu Pro Pro 

    210                 215                 220                 





Arg Pro Glu Gly Arg Gly Glu Ser Arg Cys Gln Gly Met His Glu Gly 

225                 230                 235                 240 





Ala Ser Glu Arg Pro Leu Ser Pro Gly Ala His Val Pro Leu Leu Ala 

                245                 250                 255     





Lys Asn Leu Asp Val Arg Thr Glu Ala Ala Pro Cys Pro Gly Ser Ala 

            260                 265                 270         





Phe Ala Asp Arg Glu Ala Pro Trp Asp Ser Ala Pro Met Ala Ser Pro 

        275                 280                 285             





Gly Leu Pro Ala Ala Ser Thr Gln Pro Trp Arg Lys Leu Pro Glu Gln 

    290                 295                 300                 





Lys Ser Pro Thr Ala Gly Lys Pro Cys Ala Leu Gln Arg Gln Gln Ala 

305                 310                 315                 320 





Thr Ala Ala Glu Lys Pro Trp Asp Ala Lys Ala Pro Glu Gly Arg Leu 

                325                 330                 335     





Arg Lys Cys Glu Ser Thr Asp Ser Gly Tyr Leu Ser Arg Ser Asp Ser 

            340                 345                 350         





Ala Glu Gln Pro His Ala Pro Cys Ser Pro Leu His Ser Leu Ser Glu 

        355                 360                 365             





His Ser Ala Glu Ser Glu Gly Glu Gly Gly Pro Gly Pro Gly Pro Gly 

    370                 375                 380                 





Val Ala Gly Ala Glu Pro Gly Ala Arg Glu Ala Gly Leu Glu Leu Glu 

385                 390                 395                 400 





Lys Lys Arg Leu Glu Glu Arg Ile Ala Gln Leu Ile Ser His Asn Gln 

                405                 410                 415     





Ala Val Val Asp Asp Ala Gln Leu Asp Asn Val Arg Pro Arg Lys Thr 

            420                 425                 430         





Gly Leu Ser Lys Gln Gly Ser Ile Asp Leu Pro Thr Pro Tyr Thr Tyr 

        435                 440                 445             





Lys Asp Ser Phe His Phe Asp Ile Arg Ala Leu Glu Pro Gly Arg Arg 

    450                 455                 460                 





Arg Ala Pro Gly Pro Val Arg Ser Thr Trp Thr Pro Pro Asp Lys Ser 

465                 470                 475                 480 





Arg Pro Leu Phe Phe His Ser Val Pro Thr Gln Leu Ser Thr Thr Val 

                485                 490                 495     





Glu Cys Val Pro Val Thr Arg Ser Asn Ser Leu Pro Phe Val Glu Gly 

            500                 505                 510         





Ser Arg Thr Trp Leu Glu Pro Arg Glu Pro Arg Asp Pro Trp Ser Arg 

        515                 520                 525             





Thr Gln Lys Pro Leu Ser Pro Arg Pro Gly Pro Ala Arg Leu Gly Cys 

    530                 535                 540                 





Arg Ser Gly Leu Ser Ser Thr Asp Val Pro Ser Gly His Pro Arg Ala 

545                 550                 555                 560 





Leu Val Arg Gln Ala Ala Val Glu Asp Leu Pro Gly Thr Pro Ile Gly 

                565                 570                 575     





Asp Ala Leu Val Pro Ala Glu Asp Thr Asp Ala Lys Arg Thr Ala Ala 

            580                 585                 590         





Arg Glu Ala Met Ala Gly Lys Gly Arg Ala Gly Gly Arg Lys Cys Gly 

        595                 600                 605             





Gln Arg Arg Leu Lys Met Phe Ser Gln Glu Lys Trp Gln Val Tyr Gly 

    610                 615                 620                 





Asp Glu Thr Phe Lys Arg Ile Tyr Gln Lys Met Lys Ala Ser Pro His 

625                 630                 635                 640 





Gly Gly Lys Lys Ala Arg Glu Val Gly Met Gly Ser Gly Ala Glu Leu 

                645                 650                 655     





Gly Phe Pro Leu Gln Lys Glu Ala Ala Gly Ser Ser Gly Thr Val Pro 

            660                 665                 670         





Thr Gln Asp Arg Arg Thr Pro Val His Glu Asp Ile Ser Ala Gly Ala 

        675                 680                 685             





Thr Pro Glu Pro Trp Gly Asn Pro Pro Ala Leu Glu Ala Ser Leu Val 

    690                 695                 700                 





Thr Glu Pro Thr Lys His Gly Glu Thr Val Ala Arg Arg Gly Asp Ser 

705                 710                 715                 720 





Asp Arg Pro Arg Val Glu Glu Ala Val Ser Ser Pro Ala Leu Gly Gly 

                725                 730                 735     





Arg Asp Ser Pro Cys Ser Gly Ser Arg Ser Pro Leu Val Ser Pro Asn 

            740                 745                 750         





Gly Arg Leu Glu Leu Gly Trp Gln Met Pro Pro Ala Pro Gly Pro Leu 

        755                 760                 765             





Lys Gly Gly Asp Val Glu Ala Pro Arg Pro Val Trp Pro Asp Pro Lys 

    770                 775                 780                 





Leu Glu Gly Gly Ala Arg Gly Val Gly Asp Val Gln Glu Thr Cys Leu 

785                 790                 795                 800 





Trp Ala Gln Thr Val Leu Arg Trp Pro Ser Arg Gly Ser Gly Glu Asp 

                805                 810                 815     





Lys Leu Pro Ser Glu Arg Lys Lys Leu Lys Val Glu Asp Leu His Ser 

            820                 825                 830         





Trp Lys Gln Pro Glu Pro Val Ser Ala Glu Thr Pro Gly Gly Pro Thr 

        835                 840                 845             





Gln Pro Ala Ser Leu Ser Ser Gln Lys Gln Asp Ala Asp Pro Gly Glu 

    850                 855                 860                 





Val Pro Gly Gly Ser Lys Glu Ser Ala Arg Gln Val Gly Glu Pro Leu 

865                 870                 875                 880 





Glu Ser Ser Gly Ala Ser Leu Ala Ala Ala Ser Val Ala Leu Lys Arg 

                885                 890                 895     





Val Gly Pro Arg Asp Lys Ala Thr Pro Leu His Pro Ala Ala Pro Ala 

            900                 905                 910         





Pro Ala Glu His Pro Ser Leu Ala Thr Pro Pro Gln Ala Pro Arg Val 

        915                 920                 925             





Leu Ser Ala Leu Ala Asp Asn Ala Phe Ser Pro Lys Tyr Leu Leu Arg 

    930                 935                 940                 





Leu Pro Gln Ala Glu Thr Pro Leu Pro Leu Pro Ile Pro Trp Gly Pro 

945                 950                 955                 960 





Arg His Ser Gln Asp Ser Leu Cys Ser Ser Gly Trp Pro Glu Glu Arg 

                965                 970                 975     





Ala Ser Phe Val Gly Ser Gly Leu Gly Thr Pro Leu Ser Pro Ser Pro 

            980                 985                 990         





Ala Ser Gly Pro Ser Pro Gly Glu  Ala Asp Ser Ile Leu  Glu Asp Pro 

        995                 1000                 1005             





Ser Cys  Ser Arg Pro Gln Asp  Gly Arg Lys Gly Ala  Gln Leu Gly 

    1010                 1015                 1020             





Gly Asp  Lys Gly Asp Arg Met  Ala Thr Ser Arg Pro  Ala Ala Arg 

    1025                 1030                 1035             





Glu Leu  Pro Ile Ser Ala Pro  Gly Ala Pro Arg Glu  Ala Thr Ser 

    1040                 1045                 1050             





Ser Pro  Pro Thr Pro Thr Cys  Glu Ala His Leu Val  Gln Asp Met 

    1055                 1060                 1065             





Glu Gly  Asp Ser His Arg Ile  His Arg Leu Cys Met  Gly Ser Thr 

    1070                 1075                 1080             





Leu Ala  Arg Ala Arg Leu Ser  Gly Asp Val Leu Asn  Pro Trp Val 

    1085                 1090                 1095             





Pro Asn  Trp Glu Leu Gly Glu  Pro Pro Gly Asn Ala  Pro Glu Asp 

    1100                 1105                 1110             





Pro Ser  Ser Gly Pro Leu Val  Gly Pro Asp Pro Cys  Ser Pro Leu 

    1115                 1120                 1125             





Gln Pro  Gly Ser Phe Leu Thr  Ala Leu Thr Arg Pro  Gln Gly Val 

    1130                 1135                 1140             





Pro Pro  Gly Trp Pro Glu Leu  Ala Leu Ser Ser His  Ser Gly Thr 

    1145                 1150                 1155             





Ser Arg  Ser His Ser Thr Arg  Ser Pro His Ser Thr  Gln Asn Pro 

    1160                 1165                 1170             





Phe Pro  Ser Leu Lys Ala Glu  Pro Arg Leu Thr Trp  Cys Cys Leu 

    1175                 1180                 1185             





Ser Arg  Ser Val Pro Leu Pro  Ala Glu Gln Lys Ala  Lys Ala Ala 

    1190                 1195                 1200             





Ser Val  Tyr Leu Ala Val His  Phe Pro Gly Ser Ser  Leu Arg Asp 

    1205                 1210                 1215             





Glu Gly  Pro Asn Gly Pro Pro  Gly Ser Asn Gly Gly  Trp Thr Trp 

    1220                 1225                 1230             





Thr Ser  Pro Gly Glu Gly Gly  Pro Ala Gln Met Ser  Lys Phe Ser 

    1235                 1240                 1245             





Tyr Pro  Thr Val Pro Gly Val  Met Pro Gln His Gln  Val Ser Glu 

    1250                 1255                 1260             





Pro Glu  Trp Lys Lys Gly Leu  Pro Trp Arg Ala Lys  Met Ser Arg 

    1265                 1270                 1275             





Gly Asn  Ser Lys Gln Arg Lys  Leu Lys Ile Asn Pro  Lys Arg Tyr 

    1280                 1285                 1290             





Lys Gly  Asn Phe Leu Gln Ser  Cys Val Gln Leu Arg  Ala Ser Arg 

    1295                 1300                 1305             





Leu Arg  Thr Pro Thr Trp Val  Arg Arg Arg Ser Arg  His Pro Pro 

    1310                 1315                 1320             





Ala Leu  Glu Gly Leu Lys Pro  Cys Arg Thr Pro Gly  Gln Thr Ser 

    1325                 1330                 1335             





Ser Glu  Ile Ala Gly Leu Asn  Leu Gln Glu Glu Pro  Ser Cys Ala 

    1340                 1345                 1350             





Thr Ser  Glu Ser Pro Pro Cys  Cys Gly Lys Glu Glu  Lys Lys Glu 

    1355                 1360                 1365             





Gly Asp  Cys Arg Gln Thr Leu  Gly Thr Leu Ser Leu  Gly Thr Ser 

    1370                 1375                 1380             





Ser Arg  Ile Val Arg Glu Met  Asp Lys Arg Thr Val  Lys Asp Ile 

    1385                 1390                 1395             





Ser Pro  Ser Ala Gly Glu His  Gly Asp Cys Thr Thr  His Ser Thr 

    1400                 1405                 1410             





Ala Ala  Thr Ser Gly Leu Ser  Leu Gln Ser Asp Thr  Cys Leu Ala 

    1415                 1420                 1425             





Val Val  Asn Asp Val Pro Leu  Pro Pro Gly Lys Gly  Leu Asp Leu 

    1430                 1435                 1440             





Gly Leu  Leu Glu Thr Gln Leu  Leu Ala Ser Gln Asp  Ser Val Ser 

    1445                 1450                 1455             





Thr Asp  Pro Lys Pro Tyr Ile  Phe Ser Asp Ala Gln  Arg Pro Ser 

    1460                 1465                 1470             





Ser Phe  Gly Ser Lys Gly Thr  Phe Pro His His Asp  Ile Ala Thr 

    1475                 1480                 1485             





Ser Val  Ala Ala Val Cys Ile  Ser Leu Pro Val Arg  Thr Asp His 

    1490                 1495                 1500             





Ile Ala  Gln Glu Ile His Ser  Ala Glu Ser Arg Asp  His Ser Gln 

    1505                 1510                 1515             





Thr Ala  Gly Arg Thr Leu Thr  Ser Ser Ser Pro Asp  Ser Lys Val 

    1520                 1525                 1530             





Thr Glu  Glu Gly Arg Ala Gln  Thr Leu Leu Pro Gly  Arg Pro Ser 

    1535                 1540                 1545             





Ser Gly  Gln Arg Ile Ser Asp  Ser Val Pro Leu Glu  Ser Thr Glu 

    1550                 1555                 1560             





Lys Thr  His Leu Glu Ile Pro  Ala Ser Gly Pro Ser  Ser Ala Ser 

    1565                 1570                 1575             





Ser His  His Lys Glu Gly Arg  His Lys Thr Phe Phe  Pro Ser Arg 

    1580                 1585                 1590             





Gly Gln  Tyr Gly Cys Gly Glu  Met Thr Val Pro Cys  Pro Ser Leu 

    1595                 1600                 1605             





Gly Ser  Asp Gly Arg Lys Arg  Gln Val Ser Gly Leu  Ile Thr Arg 

    1610                 1615                 1620             





Lys Asp  Ser Val Val Pro Ser  Lys Pro Glu Gln Pro  Ile Glu Ile 

    1625                 1630                 1635             





Pro Glu  Ala Pro Ser Lys Ser  Leu Lys Lys Arg Ser  Leu Glu Gly 

    1640                 1645                 1650             





Met Arg  Lys Gln Thr Arg Val  Glu Phe Ser Asp Thr  Ser Ser Asp 

    1655                 1660                 1665             





Asp Glu  Asp Arg Leu Val Ile  Glu Ile 

    1670                 1675         





<210>  51

<211>  1466

<212>  DNA

<213>  Homo sapiens



<400>  51

gcgcgtgcgc atcatcgttt cgacgcgctc ggaagcaact tcctttgcct gctcaccgcc       60



agcgtaggtg ctaccaccgc tgccgtcgcc gccgccattt tgatggcagg aagagtccgg      120



ttctgggaca gctggagaca gtggtggtga ctgaaataac tttaccaaag gaaagctatt      180



ttgcgaacta tcttctccag cggagatggc caatgtgctt tgtaacagag ccagactggt      240



ttcctatctc ccaggatttt gctctttagt taaaagggtt gtcaatccca aagccttttc      300



gactgcagga tcatcaggtt cggatgagtc tcatgtggct gctgcacctc cagatatatg      360



ctctcgaaca gtgtggcctg atgaaactat gggacccttt ggacctcaag atcagaggtt      420



ccagcttcct gggaacatag gttttgattg tcacctcaat gggactgctt cacagaagaa      480



aagcctggtt cataaaactt tgcctgatgt tctagcagaa cctttatcaa gtgaaagaca      540



tgagtttgtg atggcacaat atgtgaatga atttcagggt aatgatgcac ctgttgaaca      600



agaaattaac agtgcagaaa cttactttga aagtgccaga gtagagtgtg caatacagac      660



atgtccagaa ttgctgcgaa aagattttga atcactgttt ccagaagtag ctaatggcaa      720



actaatgatt ctgactgtaa cacaaaaaac taagaatgat atgactgttt ggagtgaaga      780



agtagaaatt gaaagagaag tgctcttaga aaagttcatc aatggtgcta aggaaatttg      840



ctatgctctt cgagctgagg gttattgggc tgactttatt gacccatcat ctggtttggc      900



attttttgga ccatatacaa acaacactct ttttgaaact gatgaacgct accgacattt      960



aggattctct gttgatgacc ttggatgctg taaagtgatt cgtcatagtc tctggggtac     1020



ccatgtagtt gtagggagta tcttcactaa tgcaacacca gacagccata ttatgaagaa     1080



attaagtgga aattagcaga aatatccatt catttgctgt actatttgta tgtaatattt     1140



gggttgatct ataaacactg tcagactaaa gtttttaaaa tatatttatt tctaagtatt     1200



tatttcagca tttatgaatt tacaacattg gcaagtgatt tgggatttta aaattgcaaa     1260



tgttcattta ttcatatcat tgaatacacg ttgaacacat ccacattgta taggatgtgg     1320



taattagctt gtaaccaggg tatgatctgc tattgttatt tctcctcttt attggaaaaa     1380



ggcctcagtt ttaattattt tcttcccaaa ataaatcaca catttggtta caataataaa     1440



aaaaaaaaaa aaaaaaaaaa aaaaaa                                          1466





<210>  52

<211>  296

<212>  PRT

<213>  Homo sapiens



<400>  52



Met Ala Asn Val Leu Cys Asn Arg Ala Arg Leu Val Ser Tyr Leu Pro 

1               5                   10                  15      





Gly Phe Cys Ser Leu Val Lys Arg Val Val Asn Pro Lys Ala Phe Ser 

            20                  25                  30          





Thr Ala Gly Ser Ser Gly Ser Asp Glu Ser His Val Ala Ala Ala Pro 

        35                  40                  45              





Pro Asp Ile Cys Ser Arg Thr Val Trp Pro Asp Glu Thr Met Gly Pro 

    50                  55                  60                  





Phe Gly Pro Gln Asp Gln Arg Phe Gln Leu Pro Gly Asn Ile Gly Phe 

65                  70                  75                  80  





Asp Cys His Leu Asn Gly Thr Ala Ser Gln Lys Lys Ser Leu Val His 

                85                  90                  95      





Lys Thr Leu Pro Asp Val Leu Ala Glu Pro Leu Ser Ser Glu Arg His 

            100                 105                 110         





Glu Phe Val Met Ala Gln Tyr Val Asn Glu Phe Gln Gly Asn Asp Ala 

        115                 120                 125             





Pro Val Glu Gln Glu Ile Asn Ser Ala Glu Thr Tyr Phe Glu Ser Ala 

    130                 135                 140                 





Arg Val Glu Cys Ala Ile Gln Thr Cys Pro Glu Leu Leu Arg Lys Asp 

145                 150                 155                 160 





Phe Glu Ser Leu Phe Pro Glu Val Ala Asn Gly Lys Leu Met Ile Leu 

                165                 170                 175     





Thr Val Thr Gln Lys Thr Lys Asn Asp Met Thr Val Trp Ser Glu Glu 

            180                 185                 190         





Val Glu Ile Glu Arg Glu Val Leu Leu Glu Lys Phe Ile Asn Gly Ala 

        195                 200                 205             





Lys Glu Ile Cys Tyr Ala Leu Arg Ala Glu Gly Tyr Trp Ala Asp Phe 

    210                 215                 220                 





Ile Asp Pro Ser Ser Gly Leu Ala Phe Phe Gly Pro Tyr Thr Asn Asn 

225                 230                 235                 240 





Thr Leu Phe Glu Thr Asp Glu Arg Tyr Arg His Leu Gly Phe Ser Val 

                245                 250                 255     





Asp Asp Leu Gly Cys Cys Lys Val Ile Arg His Ser Leu Trp Gly Thr 

            260                 265                 270         





His Val Val Val Gly Ser Ile Phe Thr Asn Ala Thr Pro Asp Ser His 

        275                 280                 285             





Ile Met Lys Lys Leu Ser Gly Asn 

    290                 295     





<210>  53

<211>  1740

<212>  DNA

<213>  Homo sapiens



<400>  53

agtggtctcc tgccgccacc tggaccgggg acagtaacgc ctagggagcc ccaagacctc       60



ttgagagagc atttcagctc tgttgacaaa cctcaaccac ttgagggact tcgctggaaa      120



gaaacgttct agaaagacca agtggatacc aggagccccg tgaggtgcgt gtggcctcag      180



cttgcagagg agtgcacttg ccagacactt cggggctttg aagagcacag ctcatttaag      240



atgggcacag gtgcatcaga gaaacaagca gagcagaagg tccgccgtgc cttcgaggcc      300



tccgaggaag cccacgggac tctggcagcc tcaaccccct gggtggccat gggctctgcc      360



tatggttcct gtacctgctt gggagcccag cctgtaactg acctggccct ctggcctgtc      420



atctactcct gcatgggatt ttccccacaa gcttacccag ccttctgggc ttacccgtgg      480



gtgctctatg gtgggtatct ctggatgggt tatccccctc cagctgcctt ggtgccttca      540



gtgtggctgt attggagggg cgcctccagc tttgaccccc tcataggaag tccgtatctg      600



gcagccttgg cccccaacct atttcctttc cccatgaaat tcccacccac ctactccttg      660



gcttctccca ctctgggcgg ggccacctcc agccactgtc cccaggtggg atgctggact      720



ccagccagct cagcccccag ggctgccgta gaggggccat ccagaggagc tccctacttg      780



aagacatgca aagcccctcc ctcagaatgg gcctccaggt tcggtatttg ggcacctttg      840



ccctgctgca gttcagagct ccgccctctg cccccttccc ccattgaaga ttctcagctg      900



gacccgggct gctcccgctc ctcctcccgg tcaccctgca gggcccgccg ccgcctcttt      960



gagtgctaat cagccctcta gacccagacc cacccaacaa tcagagacat gtctggtgga     1020



gcccagccag ctgtggactt taagtttttg gaagagtctc agatgtaggt tgtttactat     1080



tcctcagtac agagtacacc tcctggactc atgcaaggcc cctctatttg ctatttctct     1140



ttactttctt gtttttctgt ttgcccttca accctgatac tggcaccttt tctcctcccc     1200



agactgtcct gggcccgccc tctagtagat ttgctgtgag tcctcaaaca tgcatgcatg     1260



caaccttgta aaatgagctt atttaagctc aatccaacct gtagaagcgc tcagttagaa     1320



taggcctcca ggtttggtat ttgggcacct gtgccaccct ccagcccagg actctctctg     1380



cccctcctca gcaaagaccc tcagcaggat ccccgcatcc ctggccaccc tgtggggcct     1440



gctgctgtct cttccagcat tggtgtgtcc tccagggaac cacacactca agcactttgg     1500



aacccatgga atccagtgag cacgtgctgt gggctctgcc tagaagcttc caaaacctgt     1560



ttgttccagt ggacacagag taggaaatgc tgactcgttc agagcgctag tgcccttggg     1620



tccttgcggg tgtgctcttc tcactcctca ccccatcagc accttctggg gtaatgcaca     1680



caccagtaaa atgtacagtg catgctttta aaaattttta aataaatgat actatgctat     1740





<210>  54

<211>  992

<212>  DNA

<213>  Homo sapiens



<400>  54

aggccaccgg ctttccgcta ccggattggc tgcgtccggg tgctgaggcc cggcccattt       60



ccccgggtcc tttgatcacg cgcctgacgg cttttccggg gcccgggagc caaccgaggg      120



cgttcctgtc ggggctgcag cggcgggagg gagcccagtg gaggcgccct cccgaagcgc      180



cactgcccat gctgaccacc cagccctccg gctgctgatg tcatgagtaa caccactgtg      240



cccaatgccc cccaggccaa cagcgactcc atggtgggct atgtgttggg gcccttcttc      300



ctcatcaccc tggtcggggt ggtggtggct gtggtaatgt atgtacagaa gaaaaagcgg      360



gtggaccggc tgcgccatca cctgctcccc atgtacagct atgacccagc tgaggaactg      420



catgaggctg agcaggagct gctctctgac atgggagacc ccaaggtggt acatggctgg      480



cagagtggct accagcacaa gcggatgcca ctgctggatg tcaagacgtg acctgacccc      540



cttgccccac ccttcagagc ctggggtcct ggactgcctg gggccctgcc atctgcttcc      600



cctgctgtca cctggctccc cctgctgggt gctgggtctc catttctccc tccacccacc      660



ctcagcagca tctgcttccc atgccctcac catcacctca ctgcccccag gccttctgcc      720



ctttgtgggt gttgagctca ccgcccaccc acaggcactc atgggaagag gctttccttc      780



tgggatgggg gcggctggta gacacctttg ctttctctag ccctcctggg ctgggcttgg      840



gcacaaatcc ccaggcaggc tttggagttg tttccatggt gatggggcca gatgtatagt      900



attcagtata tattttgtaa ataaaatgtt ttgtggctag gggttttgat ttcaaaaaaa      960



aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                    992





<210>  55

<211>  159

<212>  PRT

<213>  Homo sapiens



<400>  55



Met Tyr Arg Arg Lys Ser Gly Trp Thr Gly Cys Ala Ile Thr Cys Ser 

1               5                   10                  15      





Pro Cys Thr Ala Met Thr Gln Leu Arg Asn Cys Met Arg Leu Ser Arg 

            20                  25                  30          





Ser Cys Ser Leu Thr Trp Glu Thr Pro Arg Trp Tyr Met Ala Gly Arg 

        35                  40                  45              





Val Ala Thr Ser Thr Ser Gly Cys His Cys Trp Met Ser Arg Arg Asp 

    50                  55                  60                  





Leu Thr Pro Leu Pro His Pro Ser Glu Pro Gly Val Leu Asp Cys Leu 

65                  70                  75                  80  





Gly Pro Cys His Leu Leu Pro Leu Leu Ser Pro Gly Ser Pro Cys Trp 

                85                  90                  95      





Val Leu Gly Leu His Phe Ser Leu His Pro Pro Ser Ala Ala Ser Ala 

            100                 105                 110         





Ser His Ala Leu Thr Ile Thr Ser Leu Pro Pro Gly Leu Leu Pro Phe 

        115                 120                 125             





Val Gly Val Glu Leu Thr Ala His Pro Gln Ala Leu Met Gly Arg Gly 

    130                 135                 140                 





Phe Pro Ser Gly Met Gly Ala Ala Gly Arg His Leu Cys Phe Leu 

145                 150                 155                 





<210>  56

<211>  932

<212>  DNA

<213>  Homo sapiens



<400>  56

aggccaccgg ctttccgcta ccggattggc tgcgtccggg tgctgaggcc cggcccattt       60



ccccgggtcc tttgatcacg cgcctgacgg cttttccggg gcccgggagc caaccgaggg      120



cgttcctgtc ggggctgcag cggcgggagg gagcccagtg gaggcgccct cccgaagcgc      180



cactgcccat gctgaccacc cagccctccg gctgctgatg tcatgagtaa caccactgtg      240



cccaatgccc cccaggccaa cagcgactcc atggtaatgt atgtacagaa gaaaaagcgg      300



gtggaccggc tgcgccatca cctgctcccc atgtacagct atgacccagc tgaggaactg      360



catgaggctg agcaggagct gctctctgac atgggagacc ccaaggtggt acatggctgg      420



cagagtggct accagcacaa gcggatgcca ctgctggatg tcaagacgtg acctgacccc      480



cttgccccac ccttcagagc ctggggtcct ggactgcctg gggccctgcc atctgcttcc      540



cctgctgtca cctggctccc cctgctgggt gctgggtctc catttctccc tccacccacc      600



ctcagcagca tctgcttccc atgccctcac catcacctca ctgcccccag gccttctgcc      660



ctttgtgggt gttgagctca ccgcccaccc acaggcactc atgggaagag gctttccttc      720



tgggatgggg gcggctggta gacacctttg ctttctctag ccctcctggg ctgggcttgg      780



gcacaaatcc ccaggcaggc tttggagttg tttccatggt gatggggcca gatgtatagt      840



attcagtata tattttgtaa ataaaatgtt ttgtggctag gggttttgat ttcaaaaaaa      900



aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                    932





<210>  57

<211>  159

<212>  PRT

<213>  Homo sapiens



<400>  57



Met Tyr Arg Arg Lys Ser Gly Trp Thr Gly Cys Ala Ile Thr Cys Ser 

1               5                   10                  15      





Pro Cys Thr Ala Met Thr Gln Leu Arg Asn Cys Met Arg Leu Ser Arg 

            20                  25                  30          





Ser Cys Ser Leu Thr Trp Glu Thr Pro Arg Trp Tyr Met Ala Gly Arg 

        35                  40                  45              





Val Ala Thr Ser Thr Ser Gly Cys His Cys Trp Met Ser Arg Arg Asp 

    50                  55                  60                  





Leu Thr Pro Leu Pro His Pro Ser Glu Pro Gly Val Leu Asp Cys Leu 

65                  70                  75                  80  





Gly Pro Cys His Leu Leu Pro Leu Leu Ser Pro Gly Ser Pro Cys Trp 

                85                  90                  95      





Val Leu Gly Leu His Phe Ser Leu His Pro Pro Ser Ala Ala Ser Ala 

            100                 105                 110         





Ser His Ala Leu Thr Ile Thr Ser Leu Pro Pro Gly Leu Leu Pro Phe 

        115                 120                 125             





Val Gly Val Glu Leu Thr Ala His Pro Gln Ala Leu Met Gly Arg Gly 

    130                 135                 140                 





Phe Pro Ser Gly Met Gly Ala Ala Gly Arg His Leu Cys Phe Leu 

145                 150                 155                 





<210>  58

<211>  1244

<212>  DNA

<213>  Homo sapiens



<400>  58

aggccaccgg ctttccgcta ccggattggc tgcgtccggg tgctgaggcc cggcccattt       60



ccccgggtcc tttgatcacg cgcctgacgg cttttccggg gcccgggagc caaccgaggg      120



cgttcctgtc ggggctgcag cggcgggagg taaggcatgg ccaggccggc tgggctgcag      180



agcgccggca cgggtccacg cctcgggtga cgggcttcca ggatgttcgg gcgcggggcg      240



gcccatccgc atcccccaac acccccacct ccggcctgag cctcccagcg ccgtgggaac      300



cacctcctgt ccgctgttgc tggcccgcat cctagcagcg gcctgacgcc ctccccaccc      360



tggcatgccc ccttgacctg ggacgatgag catacgactg gggagcccag tggaggcgcc      420



ctcccgaagc gccactgccc atgctgacca cccagccctc cggctgctga tgtcatgagt      480



aacaccactg tgcccaatgc cccccaggcc aacagcgact ccatggtggg ctatgtgttg      540



gggcccttct tcctcatcac cctggtcggg gtggtggtgg ctgtggtaat gtatgtacag      600



aagaaaaagc gggtggaccg gctgcgccat cacctgctcc ccatgtacag ctatgaccca      660



gctgaggaac tgcatgaggc tgagcaggag ctgctctctg acatgggaga ccccaaggtg      720



gtacatggct ggcagagtgg ctaccagcac aagcggatgc cactgctgga tgtcaagacg      780



tgacctgacc cccttgcccc acccttcaga gcctggggtc ctggactgcc tggggccctg      840



ccatctgctt cccctgctgt cacctggctc cccctgctgg gtgctgggtc tccatttctc      900



cctccaccca ccctcagcag catctgcttc ccatgccctc accatcacct cactgccccc      960



aggccttctg ccctttgtgg gtgttgagct caccgcccac ccacaggcac tcatgggaag     1020



aggctttcct tctgggatgg gggcggctgg tagacacctt tgctttctct agccctcctg     1080



ggctgggctt gggcacaaat ccccaggcag gctttggagt tgtttccatg gtgatggggc     1140



cagatgtata gtattcagta tatattttgt aaataaaatg ttttgtggct aggggttttg     1200



atttcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      1244





<210>  59

<211>  159

<212>  PRT

<213>  Homo sapiens



<400>  59



Met Tyr Arg Arg Lys Ser Gly Trp Thr Gly Cys Ala Ile Thr Cys Ser 

1               5                   10                  15      





Pro Cys Thr Ala Met Thr Gln Leu Arg Asn Cys Met Arg Leu Ser Arg 

            20                  25                  30          





Ser Cys Ser Leu Thr Trp Glu Thr Pro Arg Trp Tyr Met Ala Gly Arg 

        35                  40                  45              





Val Ala Thr Ser Thr Ser Gly Cys His Cys Trp Met Ser Arg Arg Asp 

    50                  55                  60                  





Leu Thr Pro Leu Pro His Pro Ser Glu Pro Gly Val Leu Asp Cys Leu 

65                  70                  75                  80  





Gly Pro Cys His Leu Leu Pro Leu Leu Ser Pro Gly Ser Pro Cys Trp 

                85                  90                  95      





Val Leu Gly Leu His Phe Ser Leu His Pro Pro Ser Ala Ala Ser Ala 

            100                 105                 110         





Ser His Ala Leu Thr Ile Thr Ser Leu Pro Pro Gly Leu Leu Pro Phe 

        115                 120                 125             





Val Gly Val Glu Leu Thr Ala His Pro Gln Ala Leu Met Gly Arg Gly 

    130                 135                 140                 





Phe Pro Ser Gly Met Gly Ala Ala Gly Arg His Leu Cys Phe Leu 

145                 150                 155                 





<210>  60

<211>  3301

<212>  DNA

<213>  Homo sapiens



<400>  60

cagggtaaac tgccagaagg ctaagggaaa tggaatggct gctggaggac ctgcttgggg       60



ctaaggggga tatggggctt ctctggggcc aactgaccca tgccctagcc tgcagacact      120



gcggcagcag ctgcttccag agtccaggaa atctggaact accacttctg caccgtgtgg      180



ccttccttga tcacctgtgt aagcagaaat cagaagtgga ggaagaaggg gaagaagagg      240



aagaggggga agacgaggca tctctggatc cactgaagcc atgttctcct accaaagaag      300



ctcccactgg agagcaagcc actccagccc caccccagcc atcctgtggt tctgagggcc      360



tcctcaaggc tatagggata ccagagcaaa cagtcatgca gcccgtgagc ccttccagat      420



ccttccccat cttccagatt ctgaccagct ttcctgtgag gcacaagata gcatcaggga      480



accgccagca gcagagaaaa agccagctct tctggggtct cccctctctg cacagcgagt      540



ccttggaggc catcttcctg agctcaggtg gcccctctcc tctgaagtgg tctgtttgtt      600



cttctgtctt cttcaacaag cttgccttcc tacctaggtc caacctgttg cttccccagt      660



atcactcctc agcccagttt tctacccatg gggcccatac tatggaagat ctagaaggga      720



tggcccccga tcctcagctg cttccacctc catcttctcc ttctgtctca tcactactcc      780



tccatctgag gcccttccct gtggaccaca agggagtttt atctggcgct gaggcaccca      840



cacagtcccc tggaactagc cccctggaag ttctccctgg atatgagact catttggaaa      900



ccacaggaca caaaaagatg ccccaagctt ttgagcctcc gatgccaccc ccctgccaat      960



ccccagcttc tctgtcagaa cccagaaaag ttagccctga aggaggactt gctatatcta     1020



aggacttctg gggaaccgtg ggatacagag agaaacctca ggcctctgag tcttcaatgc     1080



cagtcccttg ccctccccta gactccctgc cagaactcca gagagagagt tccctggaag     1140



atccatccag atataagccc cagtgggaat gcagagaaaa ctcaggaaac ctctgggctt     1200



ttgagtctcc agtcttggac ctcaacccag agctctctgg aaccagccct gaatgtgtcc     1260



caccagcatc tgagacacca tggaagggca tgcaaagtag agaaaatatt tgggtccctg     1320



cagacccagt ttcacctccc agccttccct cagtccctct cctggagtct ctagtaatgg     1380



gcccccaggg agtcctgtct gaatccaaag ctttgtggga gaccatgggg cagaaagaga     1440



acctctgggc atctgattcc ccagaccctg ttcatagcac acctccaacc acccttatgg     1500



aaccacacag aatcaatcct ggggaatgcc tcgctacatc agaagctaca tggaaggata     1560



ctgagcattc caggaattcc tcggcttcta ggtctccatc tctggccctc agcccacccc     1620



cagctcttgc accggagctg ctcagagtta gatccatggg ggtcctgtct gattctgaag     1680



ctagatgtgg ggacatacaa aagacaaaaa actcctgggc ctctaagcac ccagcttgta     1740



acttacccca agacctgcat ggagccagcc ctctgggagt cttgtctgat tctcagtcta     1800



ttgtagggga aatggagcaa aaagaaaact gtgttcctgt gttcccaggt aggggctcca     1860



gcccatcctc aaactctgtt tcaaagtccc acgtaagtga gcctatcgca gaccaaagca     1920



actataagcc tgacggggag gcagtggagc aaagaaagaa ccactgggcc actgagctcc     1980



cagcccccag ctcactctct actcctctac cagagccaca cattgacctt gaacttgtgt     2040



ggagaaatgt gcaacaaaga gaagttcccc aaggccccag ccctctggca gtggatcccc     2100



tacacccagt accccagcct cccaccctag ctgaagctgt gaagattgaa cgcactcatc     2160



ctggtctacc caagggagta acgtgcccag gggttaaggc agaggcccca ctctcccaga     2220



gatggactgt cccagagttg ctcacccatc ctgggatcca tgcctggcag tggagtagag     2280



agctgaaact caggctgaag aaactgcggc agagccctgc ctccagagcc cctggcccaa     2340



gtcaatcatt ttgcagctcc cctattctga gctccacaat tccagacttc tggggactcc     2400



cttcctgccc accacagcag atttatcccc ccaatccatg cccccactct tcaagttgtc     2460



atcctcaaga agttcagcgc acagtacctc agcctgtcca gtcctcccac tgtcatcact     2520



tccaatcctc ttcccagctt cagccacagg agtctggcag ggcggaacaa gggtctcaga     2580



gaggggagaa aatgaagggg aagatggtga gccaggtccc atcccaaggg ccatgtgtac     2640



acatggaggc tggtgtggac tatctatctc caggcccagg agaaccctca aactctaagg     2700



ttctggtctc aggcaagaga aaggacaagg cttcagcctc atcctcagcc aaaaagagag     2760



agcaccctag gaaacccaaa gcaggagacc atagaagagg gactgcaagg ttggggttat     2820



ccacagtcac agggaagaac caccctgccc aggccagaag cctagtagag gcccctgtaa     2880



gcacatttcc ccaaaggtct caacacaggg gccagagctc tcaacacact gctcttcccc     2940



agctgcttct ccccaaagct tcgggtcccc aggatcagcc agaggcaggg cgaagagcaa     3000



gtgacatcct gacccctcgc cactgtaagc actgtccttg ggcccacatg gagaagtatc     3060



tctccttccc taccctcaag gcttccctta ccaggggttt gcaaaaggtg ttagccaaat     3120



gcctggataa ccatcgaccc ctacccacca aatctagtca gtagagaaaa ggctggtaat     3180



actagcactt ggtatgccaa gacctgaagc caaaccaggg ggaaggtggg gatgtggaga     3240



caagaaatgg aaattctaat aaactagctg aattagataa atcccaaaaa aaaaaaaaaa     3300



a                                                                     3301





<210>  61

<211>  1044

<212>  PRT

<213>  Homo sapiens



<400>  61



Met Glu Trp Leu Leu Glu Asp Leu Leu Gly Ala Lys Gly Asp Met Gly 

1               5                   10                  15      





Leu Leu Trp Gly Gln Leu Thr His Ala Leu Ala Cys Arg His Cys Gly 

            20                  25                  30          





Ser Ser Cys Phe Gln Ser Pro Gly Asn Leu Glu Leu Pro Leu Leu His 

        35                  40                  45              





Arg Val Ala Phe Leu Asp His Leu Cys Lys Gln Lys Ser Glu Val Glu 

    50                  55                  60                  





Glu Glu Gly Glu Glu Glu Glu Glu Gly Glu Asp Glu Ala Ser Leu Asp 

65                  70                  75                  80  





Pro Leu Lys Pro Cys Ser Pro Thr Lys Glu Ala Pro Thr Gly Glu Gln 

                85                  90                  95      





Ala Thr Pro Ala Pro Pro Gln Pro Ser Cys Gly Ser Glu Gly Leu Leu 

            100                 105                 110         





Lys Ala Ile Gly Ile Pro Glu Gln Thr Val Met Gln Pro Val Ser Pro 

        115                 120                 125             





Ser Arg Ser Phe Pro Ile Phe Gln Ile Leu Thr Ser Phe Pro Val Arg 

    130                 135                 140                 





His Lys Ile Ala Ser Gly Asn Arg Gln Gln Gln Arg Lys Ser Gln Leu 

145                 150                 155                 160 





Phe Trp Gly Leu Pro Ser Leu His Ser Glu Ser Leu Glu Ala Ile Phe 

                165                 170                 175     





Leu Ser Ser Gly Gly Pro Ser Pro Leu Lys Trp Ser Val Cys Ser Ser 

            180                 185                 190         





Val Phe Phe Asn Lys Leu Ala Phe Leu Pro Arg Ser Asn Leu Leu Leu 

        195                 200                 205             





Pro Gln Tyr His Ser Ser Ala Gln Phe Ser Thr His Gly Ala His Thr 

    210                 215                 220                 





Met Glu Asp Leu Glu Gly Met Ala Pro Asp Pro Gln Leu Leu Pro Pro 

225                 230                 235                 240 





Pro Ser Ser Pro Ser Val Ser Ser Leu Leu Leu His Leu Arg Pro Phe 

                245                 250                 255     





Pro Val Asp His Lys Gly Val Leu Ser Gly Ala Glu Ala Pro Thr Gln 

            260                 265                 270         





Ser Pro Gly Thr Ser Pro Leu Glu Val Leu Pro Gly Tyr Glu Thr His 

        275                 280                 285             





Leu Glu Thr Thr Gly His Lys Lys Met Pro Gln Ala Phe Glu Pro Pro 

    290                 295                 300                 





Met Pro Pro Pro Cys Gln Ser Pro Ala Ser Leu Ser Glu Pro Arg Lys 

305                 310                 315                 320 





Val Ser Pro Glu Gly Gly Leu Ala Ile Ser Lys Asp Phe Trp Gly Thr 

                325                 330                 335     





Val Gly Tyr Arg Glu Lys Pro Gln Ala Ser Glu Ser Ser Met Pro Val 

            340                 345                 350         





Pro Cys Pro Pro Leu Asp Ser Leu Pro Glu Leu Gln Arg Glu Ser Ser 

        355                 360                 365             





Leu Glu Asp Pro Ser Arg Tyr Lys Pro Gln Trp Glu Cys Arg Glu Asn 

    370                 375                 380                 





Ser Gly Asn Leu Trp Ala Phe Glu Ser Pro Val Leu Asp Leu Asn Pro 

385                 390                 395                 400 





Glu Leu Ser Gly Thr Ser Pro Glu Cys Val Pro Pro Ala Ser Glu Thr 

                405                 410                 415     





Pro Trp Lys Gly Met Gln Ser Arg Glu Asn Ile Trp Val Pro Ala Asp 

            420                 425                 430         





Pro Val Ser Pro Pro Ser Leu Pro Ser Val Pro Leu Leu Glu Ser Leu 

        435                 440                 445             





Val Met Gly Pro Gln Gly Val Leu Ser Glu Ser Lys Ala Leu Trp Glu 

    450                 455                 460                 





Thr Met Gly Gln Lys Glu Asn Leu Trp Ala Ser Asp Ser Pro Asp Pro 

465                 470                 475                 480 





Val His Ser Thr Pro Pro Thr Thr Leu Met Glu Pro His Arg Ile Asn 

                485                 490                 495     





Pro Gly Glu Cys Leu Ala Thr Ser Glu Ala Thr Trp Lys Asp Thr Glu 

            500                 505                 510         





His Ser Arg Asn Ser Ser Ala Ser Arg Ser Pro Ser Leu Ala Leu Ser 

        515                 520                 525             





Pro Pro Pro Ala Leu Ala Pro Glu Leu Leu Arg Val Arg Ser Met Gly 

    530                 535                 540                 





Val Leu Ser Asp Ser Glu Ala Arg Cys Gly Asp Ile Gln Lys Thr Lys 

545                 550                 555                 560 





Asn Ser Trp Ala Ser Lys His Pro Ala Cys Asn Leu Pro Gln Asp Leu 

                565                 570                 575     





His Gly Ala Ser Pro Leu Gly Val Leu Ser Asp Ser Gln Ser Ile Val 

            580                 585                 590         





Gly Glu Met Glu Gln Lys Glu Asn Cys Val Pro Val Phe Pro Gly Arg 

        595                 600                 605             





Gly Ser Ser Pro Ser Ser Asn Ser Val Ser Lys Ser His Val Ser Glu 

    610                 615                 620                 





Pro Ile Ala Asp Gln Ser Asn Tyr Lys Pro Asp Gly Glu Ala Val Glu 

625                 630                 635                 640 





Gln Arg Lys Asn His Trp Ala Thr Glu Leu Pro Ala Pro Ser Ser Leu 

                645                 650                 655     





Ser Thr Pro Leu Pro Glu Pro His Ile Asp Leu Glu Leu Val Trp Arg 

            660                 665                 670         





Asn Val Gln Gln Arg Glu Val Pro Gln Gly Pro Ser Pro Leu Ala Val 

        675                 680                 685             





Asp Pro Leu His Pro Val Pro Gln Pro Pro Thr Leu Ala Glu Ala Val 

    690                 695                 700                 





Lys Ile Glu Arg Thr His Pro Gly Leu Pro Lys Gly Val Thr Cys Pro 

705                 710                 715                 720 





Gly Val Lys Ala Glu Ala Pro Leu Ser Gln Arg Trp Thr Val Pro Glu 

                725                 730                 735     





Leu Leu Thr His Pro Gly Ile His Ala Trp Gln Trp Ser Arg Glu Leu 

            740                 745                 750         





Lys Leu Arg Leu Lys Lys Leu Arg Gln Ser Pro Ala Ser Arg Ala Pro 

        755                 760                 765             





Gly Pro Ser Gln Ser Phe Cys Ser Ser Pro Ile Leu Ser Ser Thr Ile 

    770                 775                 780                 





Pro Asp Phe Trp Gly Leu Pro Ser Cys Pro Pro Gln Gln Ile Tyr Pro 

785                 790                 795                 800 





Pro Asn Pro Cys Pro His Ser Ser Ser Cys His Pro Gln Glu Val Gln 

                805                 810                 815     





Arg Thr Val Pro Gln Pro Val Gln Ser Ser His Cys His His Phe Gln 

            820                 825                 830         





Ser Ser Ser Gln Leu Gln Pro Gln Glu Ser Gly Arg Ala Glu Gln Gly 

        835                 840                 845             





Ser Gln Arg Gly Glu Lys Met Lys Gly Lys Met Val Ser Gln Val Pro 

    850                 855                 860                 





Ser Gln Gly Pro Cys Val His Met Glu Ala Gly Val Asp Tyr Leu Ser 

865                 870                 875                 880 





Pro Gly Pro Gly Glu Pro Ser Asn Ser Lys Val Leu Val Ser Gly Lys 

                885                 890                 895     





Arg Lys Asp Lys Ala Ser Ala Ser Ser Ser Ala Lys Lys Arg Glu His 

            900                 905                 910         





Pro Arg Lys Pro Lys Ala Gly Asp His Arg Arg Gly Thr Ala Arg Leu 

        915                 920                 925             





Gly Leu Ser Thr Val Thr Gly Lys Asn His Pro Ala Gln Ala Arg Ser 

    930                 935                 940                 





Leu Val Glu Ala Pro Val Ser Thr Phe Pro Gln Arg Ser Gln His Arg 

945                 950                 955                 960 





Gly Gln Ser Ser Gln His Thr Ala Leu Pro Gln Leu Leu Leu Pro Lys 

                965                 970                 975     





Ala Ser Gly Pro Gln Asp Gln Pro Glu Ala Gly Arg Arg Ala Ser Asp 

            980                 985                 990         





Ile Leu Thr Pro Arg His Cys Lys  His Cys Pro Trp Ala  His Met Glu 

        995                 1000                 1005             





Lys Tyr  Leu Ser Phe Pro Thr  Leu Lys Ala Ser Leu  Thr Arg Gly 

    1010                 1015                 1020             





Leu Gln  Lys Val Leu Ala Lys  Cys Leu Asp Asn His  Arg Pro Leu 

    1025                 1030                 1035             





Pro Thr  Lys Ser Ser Gln 

    1040                 





<210>  62

<211>  3198

<212>  DNA

<213>  Homo sapiens



<400>  62

aaaggcagag aacaaaggaa ggaggaagtt aacttgtgga atgctgagaa aggaactacc       60



acttctgcac cgtgtggcct tccttgatca cctgtgtaag cagaaatcag aagtggagga      120



agaaggggaa gaagaggaag agggggaaga cgaggcatct ctggatccac tgaagccatg      180



ttctcctacc aaagaagctc ccactggaga gcaagccact ccagccccac cccagccatc      240



ctgtggttct gagggcctcc tcaaggctat agggatacca gagcaaacag tcatgcagcc      300



cgtgagccct tccagatcct tccccatctt ccagattctg accagctttc ctgtgaggca      360



caagatagca tcagggaacc gccagcagca gagaaaaagc cagctcttct ggggtctccc      420



ctctctgcac agcgagtcct tggaggccat cttcctgagc tcaggtggcc cctctcctct      480



gaagtggtct gtttgttctt ctgtcttctt caacaagctt gccttcctac ctaggtccaa      540



cctgttgctt ccccagtatc actcctcagc ccagttttct acccatgggg cccatactat      600



ggaagatcta gaagggatgg cccccgatcc tcagctgctt ccacctccat cttctccttc      660



tgtctcatca ctactcctcc atctgaggcc cttccctgtg gaccacaagg gagttttatc      720



tggcgctgag gcacccacac agtcccctgg aactagcccc ctggaagttc tccctggata      780



tgagactcat ttggaaacca caggacacaa aaagatgccc caagcttttg agcctccgat      840



gccacccccc tgccaatccc cagcttctct gtcagaaccc agaaaagtta gccctgaagg      900



aggacttgct atatctaagg acttctgggg aaccgtggga tacagagaga aacctcaggc      960



ctctgagtct tcaatgccag tcccttgccc tcccctagac tccctgccag aactccagag     1020



agagagttcc ctggaagatc catccagata taagccccag tgggaatgca gagaaaactc     1080



aggaaacctc tgggcttttg agtctccagt cttggacctc aacccagagc tctctggaac     1140



cagccctgaa tgtgtcccac cagcatctga gacaccatgg aagggcatgc aaagtagaga     1200



aaatatttgg gtccctgcag acccagtttc acctcccagc cttccctcag tccctctcct     1260



ggagtctcta gtaatgggcc cccagggagt cctgtctgaa tccaaagctt tgtgggagac     1320



catggggcag aaagagaacc tctgggcatc tgattcccca gaccctgttc atagcacacc     1380



tccaaccacc cttatggaac cacacagaat caatcctggg gaatgcctcg ctacatcaga     1440



agctacatgg aaggatactg agcattccag gaattcctcg gcttctaggt ctccatctct     1500



ggccctcagc ccacccccag ctcttgcacc ggagctgctc agagttagat ccatgggggt     1560



cctgtctgat tctgaagcta gatgtgggga catacaaaag acaaaaaact cctgggcctc     1620



taagcaccca gcttgtaact taccccaaga cctgcatgga gccagccctc tgggagtctt     1680



gtctgattct cagtctattg taggggaaat ggagcaaaaa gaaaactgtg ttcctgtgtt     1740



cccaggtagg ggctccagcc catcctcaaa ctctgtttca aagtcccacg taagtgagcc     1800



tatcgcagac caaagcaact ataagcctga cggggaggca gtggagcaaa gaaagaacca     1860



ctgggccact gagctcccag cccccagctc actctctact cctctaccag agccacacat     1920



tgaccttgaa cttgtgtgga gaaatgtgca acaaagagaa gttccccaag gccccagccc     1980



tctggcagtg gatcccctac acccagtacc ccagcctccc accctagctg aagctgtgaa     2040



gattgaacgc actcatcctg gtctacccaa gggagtaacg tgcccagggg ttaaggcaga     2100



ggccccactc tcccagagat ggactgtccc agagttgctc acccatcctg ggatccatgc     2160



ctggcagtgg agtagagagc tgaaactcag gctgaagaaa ctgcggcaga gccctgcctc     2220



cagagcccct ggcccaagtc aatcattttg cagctcccct attctgagct ccacaattcc     2280



agacttctgg ggactccctt cctgcccacc acagcagatt tatcccccca atccatgccc     2340



ccactcttca agttgtcatc ctcaagaagt tcagcgcaca gtacctcagc ctgtccagtc     2400



ctcccactgt catcacttcc aatcctcttc ccagcttcag ccacaggagt ctggcagggc     2460



ggaacaaggg tctcagagag gggagaaaat gaaggggaag atggtgagcc aggtcccatc     2520



ccaagggcca tgtgtacaca tggaggctgg tgtggactat ctatctccag gcccaggaga     2580



accctcaaac tctaaggttc tggtctcagg caagagaaag gacaaggctt cagcctcatc     2640



ctcagccaaa aagagagagc accctaggaa acccaaagca ggagaccata gaagagggac     2700



tgcaaggttg gggttatcca cagtcacagg gaagaaccac cctgcccagg ccagaagcct     2760



agtagaggcc cctgtaagca catttcccca aaggtctcaa cacaggggcc agagctctca     2820



acacactgct cttccccagc tgcttctccc caaagcttcg ggtccccagg atcagccaga     2880



ggcagggcga agagcaagtg acatcctgac ccctcgccac tgtaagcact gtccttgggc     2940



ccacatggag aagtatctct ccttccctac cctcaaggct tcccttacca ggggtttgca     3000



aaaggtgtta gccaaatgcc tggataacca tcgaccccta cccaccaaat ctagtcagta     3060



gagaaaaggc tggtaatact agcacttggt atgccaagac ctgaagccaa accaggggga     3120



aggtggggat gtggagacaa gaaatggaaa ttctaataaa ctagctgaat tagataaatc     3180



ccaaaaaaaa aaaaaaaa                                                   3198





<210>  63

<211>  1006

<212>  PRT

<213>  Homo sapiens



<400>  63



Met Leu Arg Lys Glu Leu Pro Leu Leu His Arg Val Ala Phe Leu Asp 

1               5                   10                  15      





His Leu Cys Lys Gln Lys Ser Glu Val Glu Glu Glu Gly Glu Glu Glu 

            20                  25                  30          





Glu Glu Gly Glu Asp Glu Ala Ser Leu Asp Pro Leu Lys Pro Cys Ser 

        35                  40                  45              





Pro Thr Lys Glu Ala Pro Thr Gly Glu Gln Ala Thr Pro Ala Pro Pro 

    50                  55                  60                  





Gln Pro Ser Cys Gly Ser Glu Gly Leu Leu Lys Ala Ile Gly Ile Pro 

65                  70                  75                  80  





Glu Gln Thr Val Met Gln Pro Val Ser Pro Ser Arg Ser Phe Pro Ile 

                85                  90                  95      





Phe Gln Ile Leu Thr Ser Phe Pro Val Arg His Lys Ile Ala Ser Gly 

            100                 105                 110         





Asn Arg Gln Gln Gln Arg Lys Ser Gln Leu Phe Trp Gly Leu Pro Ser 

        115                 120                 125             





Leu His Ser Glu Ser Leu Glu Ala Ile Phe Leu Ser Ser Gly Gly Pro 

    130                 135                 140                 





Ser Pro Leu Lys Trp Ser Val Cys Ser Ser Val Phe Phe Asn Lys Leu 

145                 150                 155                 160 





Ala Phe Leu Pro Arg Ser Asn Leu Leu Leu Pro Gln Tyr His Ser Ser 

                165                 170                 175     





Ala Gln Phe Ser Thr His Gly Ala His Thr Met Glu Asp Leu Glu Gly 

            180                 185                 190         





Met Ala Pro Asp Pro Gln Leu Leu Pro Pro Pro Ser Ser Pro Ser Val 

        195                 200                 205             





Ser Ser Leu Leu Leu His Leu Arg Pro Phe Pro Val Asp His Lys Gly 

    210                 215                 220                 





Val Leu Ser Gly Ala Glu Ala Pro Thr Gln Ser Pro Gly Thr Ser Pro 

225                 230                 235                 240 





Leu Glu Val Leu Pro Gly Tyr Glu Thr His Leu Glu Thr Thr Gly His 

                245                 250                 255     





Lys Lys Met Pro Gln Ala Phe Glu Pro Pro Met Pro Pro Pro Cys Gln 

            260                 265                 270         





Ser Pro Ala Ser Leu Ser Glu Pro Arg Lys Val Ser Pro Glu Gly Gly 

        275                 280                 285             





Leu Ala Ile Ser Lys Asp Phe Trp Gly Thr Val Gly Tyr Arg Glu Lys 

    290                 295                 300                 





Pro Gln Ala Ser Glu Ser Ser Met Pro Val Pro Cys Pro Pro Leu Asp 

305                 310                 315                 320 





Ser Leu Pro Glu Leu Gln Arg Glu Ser Ser Leu Glu Asp Pro Ser Arg 

                325                 330                 335     





Tyr Lys Pro Gln Trp Glu Cys Arg Glu Asn Ser Gly Asn Leu Trp Ala 

            340                 345                 350         





Phe Glu Ser Pro Val Leu Asp Leu Asn Pro Glu Leu Ser Gly Thr Ser 

        355                 360                 365             





Pro Glu Cys Val Pro Pro Ala Ser Glu Thr Pro Trp Lys Gly Met Gln 

    370                 375                 380                 





Ser Arg Glu Asn Ile Trp Val Pro Ala Asp Pro Val Ser Pro Pro Ser 

385                 390                 395                 400 





Leu Pro Ser Val Pro Leu Leu Glu Ser Leu Val Met Gly Pro Gln Gly 

                405                 410                 415     





Val Leu Ser Glu Ser Lys Ala Leu Trp Glu Thr Met Gly Gln Lys Glu 

            420                 425                 430         





Asn Leu Trp Ala Ser Asp Ser Pro Asp Pro Val His Ser Thr Pro Pro 

        435                 440                 445             





Thr Thr Leu Met Glu Pro His Arg Ile Asn Pro Gly Glu Cys Leu Ala 

    450                 455                 460                 





Thr Ser Glu Ala Thr Trp Lys Asp Thr Glu His Ser Arg Asn Ser Ser 

465                 470                 475                 480 





Ala Ser Arg Ser Pro Ser Leu Ala Leu Ser Pro Pro Pro Ala Leu Ala 

                485                 490                 495     





Pro Glu Leu Leu Arg Val Arg Ser Met Gly Val Leu Ser Asp Ser Glu 

            500                 505                 510         





Ala Arg Cys Gly Asp Ile Gln Lys Thr Lys Asn Ser Trp Ala Ser Lys 

        515                 520                 525             





His Pro Ala Cys Asn Leu Pro Gln Asp Leu His Gly Ala Ser Pro Leu 

    530                 535                 540                 





Gly Val Leu Ser Asp Ser Gln Ser Ile Val Gly Glu Met Glu Gln Lys 

545                 550                 555                 560 





Glu Asn Cys Val Pro Val Phe Pro Gly Arg Gly Ser Ser Pro Ser Ser 

                565                 570                 575     





Asn Ser Val Ser Lys Ser His Val Ser Glu Pro Ile Ala Asp Gln Ser 

            580                 585                 590         





Asn Tyr Lys Pro Asp Gly Glu Ala Val Glu Gln Arg Lys Asn His Trp 

        595                 600                 605             





Ala Thr Glu Leu Pro Ala Pro Ser Ser Leu Ser Thr Pro Leu Pro Glu 

    610                 615                 620                 





Pro His Ile Asp Leu Glu Leu Val Trp Arg Asn Val Gln Gln Arg Glu 

625                 630                 635                 640 





Val Pro Gln Gly Pro Ser Pro Leu Ala Val Asp Pro Leu His Pro Val 

                645                 650                 655     





Pro Gln Pro Pro Thr Leu Ala Glu Ala Val Lys Ile Glu Arg Thr His 

            660                 665                 670         





Pro Gly Leu Pro Lys Gly Val Thr Cys Pro Gly Val Lys Ala Glu Ala 

        675                 680                 685             





Pro Leu Ser Gln Arg Trp Thr Val Pro Glu Leu Leu Thr His Pro Gly 

    690                 695                 700                 





Ile His Ala Trp Gln Trp Ser Arg Glu Leu Lys Leu Arg Leu Lys Lys 

705                 710                 715                 720 





Leu Arg Gln Ser Pro Ala Ser Arg Ala Pro Gly Pro Ser Gln Ser Phe 

                725                 730                 735     





Cys Ser Ser Pro Ile Leu Ser Ser Thr Ile Pro Asp Phe Trp Gly Leu 

            740                 745                 750         





Pro Ser Cys Pro Pro Gln Gln Ile Tyr Pro Pro Asn Pro Cys Pro His 

        755                 760                 765             





Ser Ser Ser Cys His Pro Gln Glu Val Gln Arg Thr Val Pro Gln Pro 

    770                 775                 780                 





Val Gln Ser Ser His Cys His His Phe Gln Ser Ser Ser Gln Leu Gln 

785                 790                 795                 800 





Pro Gln Glu Ser Gly Arg Ala Glu Gln Gly Ser Gln Arg Gly Glu Lys 

                805                 810                 815     





Met Lys Gly Lys Met Val Ser Gln Val Pro Ser Gln Gly Pro Cys Val 

            820                 825                 830         





His Met Glu Ala Gly Val Asp Tyr Leu Ser Pro Gly Pro Gly Glu Pro 

        835                 840                 845             





Ser Asn Ser Lys Val Leu Val Ser Gly Lys Arg Lys Asp Lys Ala Ser 

    850                 855                 860                 





Ala Ser Ser Ser Ala Lys Lys Arg Glu His Pro Arg Lys Pro Lys Ala 

865                 870                 875                 880 





Gly Asp His Arg Arg Gly Thr Ala Arg Leu Gly Leu Ser Thr Val Thr 

                885                 890                 895     





Gly Lys Asn His Pro Ala Gln Ala Arg Ser Leu Val Glu Ala Pro Val 

            900                 905                 910         





Ser Thr Phe Pro Gln Arg Ser Gln His Arg Gly Gln Ser Ser Gln His 

        915                 920                 925             





Thr Ala Leu Pro Gln Leu Leu Leu Pro Lys Ala Ser Gly Pro Gln Asp 

    930                 935                 940                 





Gln Pro Glu Ala Gly Arg Arg Ala Ser Asp Ile Leu Thr Pro Arg His 

945                 950                 955                 960 





Cys Lys His Cys Pro Trp Ala His Met Glu Lys Tyr Leu Ser Phe Pro 

                965                 970                 975     





Thr Leu Lys Ala Ser Leu Thr Arg Gly Leu Gln Lys Val Leu Ala Lys 

            980                 985                 990         





Cys Leu Asp Asn His Arg Pro Leu  Pro Thr Lys Ser Ser  Gln 

        995                 1000                 1005     





<210>  64

<211>  3273

<212>  DNA

<213>  Homo sapiens



<400>  64

aaaggcagag aacaaaggaa ggaggaagtt aacttgtgga atgctgagaa agattcagag       60



atggtggcag cttgggaggt tgcgacagct tcatccctgg tgctctggga atatggtgca      120



aggcaaggaa ctaccacttc tgcaccgtgt ggccttcctt gatcacctgt gtaagcagaa      180



atcagaagtg gaggaagaag gggaagaaga ggaagagggg gaagacgagg catctctgga      240



tccactgaag ccatgttctc ctaccaaaga agctcccact ggagagcaag ccactccagc      300



cccaccccag ccatcctgtg gttctgaggg cctcctcaag gctataggga taccagagca      360



aacagtcatg cagcccgtga gcccttccag atccttcccc atcttccaga ttctgaccag      420



ctttcctgtg aggcacaaga tagcatcagg gaaccgccag cagcagagaa aaagccagct      480



cttctggggt ctcccctctc tgcacagcga gtccttggag gccatcttcc tgagctcagg      540



tggcccctct cctctgaagt ggtctgtttg ttcttctgtc ttcttcaaca agcttgcctt      600



cctacctagg tccaacctgt tgcttcccca gtatcactcc tcagcccagt tttctaccca      660



tggggcccat actatggaag atctagaagg gatggccccc gatcctcagc tgcttccacc      720



tccatcttct ccttctgtct catcactact cctccatctg aggcccttcc ctgtggacca      780



caagggagtt ttatctggcg ctgaggcacc cacacagtcc cctggaacta gccccctgga      840



agttctccct ggatatgaga ctcatttgga aaccacagga cacaaaaaga tgccccaagc      900



ttttgagcct ccgatgccac ccccctgcca atccccagct tctctgtcag aacccagaaa      960



agttagccct gaaggaggac ttgctatatc taaggacttc tggggaaccg tgggatacag     1020



agagaaacct caggcctctg agtcttcaat gccagtccct tgccctcccc tagactccct     1080



gccagaactc cagagagaga gttccctgga agatccatcc agatataagc cccagtggga     1140



atgcagagaa aactcaggaa acctctgggc ttttgagtct ccagtcttgg acctcaaccc     1200



agagctctct ggaaccagcc ctgaatgtgt cccaccagca tctgagacac catggaaggg     1260



catgcaaagt agagaaaata tttgggtccc tgcagaccca gtttcacctc ccagccttcc     1320



ctcagtccct ctcctggagt ctctagtaat gggcccccag ggagtcctgt ctgaatccaa     1380



agctttgtgg gagaccatgg ggcagaaaga gaacctctgg gcatctgatt ccccagaccc     1440



tgttcatagc acacctccaa ccacccttat ggaaccacac agaatcaatc ctggggaatg     1500



cctcgctaca tcagaagcta catggaagga tactgagcat tccaggaatt cctcggcttc     1560



taggtctcca tctctggccc tcagcccacc cccagctctt gcaccggagc tgctcagagt     1620



tagatccatg ggggtcctgt ctgattctga agctagatgt ggggacatac aaaagacaaa     1680



aaactcctgg gcctctaagc acccagcttg taacttaccc caagacctgc atggagccag     1740



ccctctggga gtcttgtctg attctcagtc tattgtaggg gaaatggagc aaaaagaaaa     1800



ctgtgttcct gtgttcccag gtaggggctc cagcccatcc tcaaactctg tttcaaagtc     1860



ccacgtaagt gagcctatcg cagaccaaag caactataag cctgacgggg aggcagtgga     1920



gcaaagaaag aaccactggg ccactgagct cccagccccc agctcactct ctactcctct     1980



accagagcca cacattgacc ttgaacttgt gtggagaaat gtgcaacaaa gagaagttcc     2040



ccaaggcccc agccctctgg cagtggatcc cctacaccca gtaccccagc ctcccaccct     2100



agctgaagct gtgaagattg aacgcactca tcctggtcta cccaagggag taacgtgccc     2160



aggggttaag gcagaggccc cactctccca gagatggact gtcccagagt tgctcaccca     2220



tcctgggatc catgcctggc agtggagtag agagctgaaa ctcaggctga agaaactgcg     2280



gcagagccct gcctccagag cccctggccc aagtcaatca ttttgcagct cccctattct     2340



gagctccaca attccagact tctggggact cccttcctgc ccaccacagc agatttatcc     2400



ccccaatcca tgcccccact cttcaagttg tcatcctcaa gaagttcagc gcacagtacc     2460



tcagcctgtc cagtcctccc actgtcatca cttccaatcc tcttcccagc ttcagccaca     2520



ggagtctggc agggcggaac aagggtctca gagaggggag aaaatgaagg ggaagatggt     2580



gagccaggtc ccatcccaag ggccatgtgt acacatggag gctggtgtgg actatctatc     2640



tccaggccca ggagaaccct caaactctaa ggttctggtc tcaggcaaga gaaaggacaa     2700



ggcttcagcc tcatcctcag ccaaaaagag agagcaccct aggaaaccca aagcaggaga     2760



ccatagaaga gggactgcaa ggttggggtt atccacagtc acagggaaga accaccctgc     2820



ccaggccaga agcctagtag aggcccctgt aagcacattt ccccaaaggt ctcaacacag     2880



gggccagagc tctcaacaca ctgctcttcc ccagctgctt ctccccaaag cttcgggtcc     2940



ccaggatcag ccagaggcag ggcgaagagc aagtgacatc ctgacccctc gccactgtaa     3000



gcactgtcct tgggcccaca tggagaagta tctctccttc cctaccctca aggcttccct     3060



taccaggggt ttgcaaaagg tgttagccaa atgcctggat aaccatcgac ccctacccac     3120



caaatctagt cagtagagaa aaggctggta atactagcac ttggtatgcc aagacctgaa     3180



gccaaaccag ggggaaggtg gggatgtgga gacaagaaat ggaaattcta ataaactagc     3240



tgaattagat aaatcccaaa aaaaaaaaaa aaa                                  3273





<210>  65

<211>  1031

<212>  PRT

<213>  Homo sapiens



<400>  65



Met Leu Arg Lys Ile Gln Arg Trp Trp Gln Leu Gly Arg Leu Arg Gln 

1               5                   10                  15      





Leu His Pro Trp Cys Ser Gly Asn Met Val Gln Gly Lys Glu Leu Pro 

            20                  25                  30          





Leu Leu His Arg Val Ala Phe Leu Asp His Leu Cys Lys Gln Lys Ser 

        35                  40                  45              





Glu Val Glu Glu Glu Gly Glu Glu Glu Glu Glu Gly Glu Asp Glu Ala 

    50                  55                  60                  





Ser Leu Asp Pro Leu Lys Pro Cys Ser Pro Thr Lys Glu Ala Pro Thr 

65                  70                  75                  80  





Gly Glu Gln Ala Thr Pro Ala Pro Pro Gln Pro Ser Cys Gly Ser Glu 

                85                  90                  95      





Gly Leu Leu Lys Ala Ile Gly Ile Pro Glu Gln Thr Val Met Gln Pro 

            100                 105                 110         





Val Ser Pro Ser Arg Ser Phe Pro Ile Phe Gln Ile Leu Thr Ser Phe 

        115                 120                 125             





Pro Val Arg His Lys Ile Ala Ser Gly Asn Arg Gln Gln Gln Arg Lys 

    130                 135                 140                 





Ser Gln Leu Phe Trp Gly Leu Pro Ser Leu His Ser Glu Ser Leu Glu 

145                 150                 155                 160 





Ala Ile Phe Leu Ser Ser Gly Gly Pro Ser Pro Leu Lys Trp Ser Val 

                165                 170                 175     





Cys Ser Ser Val Phe Phe Asn Lys Leu Ala Phe Leu Pro Arg Ser Asn 

            180                 185                 190         





Leu Leu Leu Pro Gln Tyr His Ser Ser Ala Gln Phe Ser Thr His Gly 

        195                 200                 205             





Ala His Thr Met Glu Asp Leu Glu Gly Met Ala Pro Asp Pro Gln Leu 

    210                 215                 220                 





Leu Pro Pro Pro Ser Ser Pro Ser Val Ser Ser Leu Leu Leu His Leu 

225                 230                 235                 240 





Arg Pro Phe Pro Val Asp His Lys Gly Val Leu Ser Gly Ala Glu Ala 

                245                 250                 255     





Pro Thr Gln Ser Pro Gly Thr Ser Pro Leu Glu Val Leu Pro Gly Tyr 

            260                 265                 270         





Glu Thr His Leu Glu Thr Thr Gly His Lys Lys Met Pro Gln Ala Phe 

        275                 280                 285             





Glu Pro Pro Met Pro Pro Pro Cys Gln Ser Pro Ala Ser Leu Ser Glu 

    290                 295                 300                 





Pro Arg Lys Val Ser Pro Glu Gly Gly Leu Ala Ile Ser Lys Asp Phe 

305                 310                 315                 320 





Trp Gly Thr Val Gly Tyr Arg Glu Lys Pro Gln Ala Ser Glu Ser Ser 

                325                 330                 335     





Met Pro Val Pro Cys Pro Pro Leu Asp Ser Leu Pro Glu Leu Gln Arg 

            340                 345                 350         





Glu Ser Ser Leu Glu Asp Pro Ser Arg Tyr Lys Pro Gln Trp Glu Cys 

        355                 360                 365             





Arg Glu Asn Ser Gly Asn Leu Trp Ala Phe Glu Ser Pro Val Leu Asp 

    370                 375                 380                 





Leu Asn Pro Glu Leu Ser Gly Thr Ser Pro Glu Cys Val Pro Pro Ala 

385                 390                 395                 400 





Ser Glu Thr Pro Trp Lys Gly Met Gln Ser Arg Glu Asn Ile Trp Val 

                405                 410                 415     





Pro Ala Asp Pro Val Ser Pro Pro Ser Leu Pro Ser Val Pro Leu Leu 

            420                 425                 430         





Glu Ser Leu Val Met Gly Pro Gln Gly Val Leu Ser Glu Ser Lys Ala 

        435                 440                 445             





Leu Trp Glu Thr Met Gly Gln Lys Glu Asn Leu Trp Ala Ser Asp Ser 

    450                 455                 460                 





Pro Asp Pro Val His Ser Thr Pro Pro Thr Thr Leu Met Glu Pro His 

465                 470                 475                 480 





Arg Ile Asn Pro Gly Glu Cys Leu Ala Thr Ser Glu Ala Thr Trp Lys 

                485                 490                 495     





Asp Thr Glu His Ser Arg Asn Ser Ser Ala Ser Arg Ser Pro Ser Leu 

            500                 505                 510         





Ala Leu Ser Pro Pro Pro Ala Leu Ala Pro Glu Leu Leu Arg Val Arg 

        515                 520                 525             





Ser Met Gly Val Leu Ser Asp Ser Glu Ala Arg Cys Gly Asp Ile Gln 

    530                 535                 540                 





Lys Thr Lys Asn Ser Trp Ala Ser Lys His Pro Ala Cys Asn Leu Pro 

545                 550                 555                 560 





Gln Asp Leu His Gly Ala Ser Pro Leu Gly Val Leu Ser Asp Ser Gln 

                565                 570                 575     





Ser Ile Val Gly Glu Met Glu Gln Lys Glu Asn Cys Val Pro Val Phe 

            580                 585                 590         





Pro Gly Arg Gly Ser Ser Pro Ser Ser Asn Ser Val Ser Lys Ser His 

        595                 600                 605             





Val Ser Glu Pro Ile Ala Asp Gln Ser Asn Tyr Lys Pro Asp Gly Glu 

    610                 615                 620                 





Ala Val Glu Gln Arg Lys Asn His Trp Ala Thr Glu Leu Pro Ala Pro 

625                 630                 635                 640 





Ser Ser Leu Ser Thr Pro Leu Pro Glu Pro His Ile Asp Leu Glu Leu 

                645                 650                 655     





Val Trp Arg Asn Val Gln Gln Arg Glu Val Pro Gln Gly Pro Ser Pro 

            660                 665                 670         





Leu Ala Val Asp Pro Leu His Pro Val Pro Gln Pro Pro Thr Leu Ala 

        675                 680                 685             





Glu Ala Val Lys Ile Glu Arg Thr His Pro Gly Leu Pro Lys Gly Val 

    690                 695                 700                 





Thr Cys Pro Gly Val Lys Ala Glu Ala Pro Leu Ser Gln Arg Trp Thr 

705                 710                 715                 720 





Val Pro Glu Leu Leu Thr His Pro Gly Ile His Ala Trp Gln Trp Ser 

                725                 730                 735     





Arg Glu Leu Lys Leu Arg Leu Lys Lys Leu Arg Gln Ser Pro Ala Ser 

            740                 745                 750         





Arg Ala Pro Gly Pro Ser Gln Ser Phe Cys Ser Ser Pro Ile Leu Ser 

        755                 760                 765             





Ser Thr Ile Pro Asp Phe Trp Gly Leu Pro Ser Cys Pro Pro Gln Gln 

    770                 775                 780                 





Ile Tyr Pro Pro Asn Pro Cys Pro His Ser Ser Ser Cys His Pro Gln 

785                 790                 795                 800 





Glu Val Gln Arg Thr Val Pro Gln Pro Val Gln Ser Ser His Cys His 

                805                 810                 815     





His Phe Gln Ser Ser Ser Gln Leu Gln Pro Gln Glu Ser Gly Arg Ala 

            820                 825                 830         





Glu Gln Gly Ser Gln Arg Gly Glu Lys Met Lys Gly Lys Met Val Ser 

        835                 840                 845             





Gln Val Pro Ser Gln Gly Pro Cys Val His Met Glu Ala Gly Val Asp 

    850                 855                 860                 





Tyr Leu Ser Pro Gly Pro Gly Glu Pro Ser Asn Ser Lys Val Leu Val 

865                 870                 875                 880 





Ser Gly Lys Arg Lys Asp Lys Ala Ser Ala Ser Ser Ser Ala Lys Lys 

                885                 890                 895     





Arg Glu His Pro Arg Lys Pro Lys Ala Gly Asp His Arg Arg Gly Thr 

            900                 905                 910         





Ala Arg Leu Gly Leu Ser Thr Val Thr Gly Lys Asn His Pro Ala Gln 

        915                 920                 925             





Ala Arg Ser Leu Val Glu Ala Pro Val Ser Thr Phe Pro Gln Arg Ser 

    930                 935                 940                 





Gln His Arg Gly Gln Ser Ser Gln His Thr Ala Leu Pro Gln Leu Leu 

945                 950                 955                 960 





Leu Pro Lys Ala Ser Gly Pro Gln Asp Gln Pro Glu Ala Gly Arg Arg 

                965                 970                 975     





Ala Ser Asp Ile Leu Thr Pro Arg His Cys Lys His Cys Pro Trp Ala 

            980                 985                 990         





His Met Glu Lys Tyr Leu Ser Phe  Pro Thr Leu Lys Ala  Ser Leu Thr 

        995                 1000                 1005             





Arg Gly  Leu Gln Lys Val Leu  Ala Lys Cys Leu Asp  Asn His Arg 

    1010                 1015                 1020             





Pro Leu  Pro Thr Lys Ser Ser  Gln 

    1025                 1030     





<210>  66

<211>  3406

<212>  DNA

<213>  Homo sapiens



<400>  66

cagggtaaac tgccagaagg ctaagggaaa tggaatggct gctggaggac ctgcttgggg       60



ctaaggggga tatggggctt ctctggggcc aactgaccca tgccctagcc tgcagacact      120



gcggcagcag ctgcttccag agtccaggaa atctggtgac actattctta ttcgtggttt      180



ggcagattca gagatggtgg cagcttggga ggttgcgaca gcttcatccc tggtgctctg      240



ggaatatggt gcaaggcaag gaactaccac ttctgcaccg tgtggccttc cttgatcacc      300



tgtgtaagca gaaatcagaa gtggaggaag aaggggaaga agaggaagag ggggaagacg      360



aggcatctct ggatccactg aagccatgtt ctcctaccaa agaagctccc actggagagc      420



aagccactcc agccccaccc cagccatcct gtggttctga gggcctcctc aaggctatag      480



ggataccaga gcaaacagtc atgcagcccg tgagcccttc cagatccttc cccatcttcc      540



agattctgac cagctttcct gtgaggcaca agatagcatc agggaaccgc cagcagcaga      600



gaaaaagcca gctcttctgg ggtctcccct ctctgcacag cgagtccttg gaggccatct      660



tcctgagctc aggtggcccc tctcctctga agtggtctgt ttgttcttct gtcttcttca      720



acaagcttgc cttcctacct aggtccaacc tgttgcttcc ccagtatcac tcctcagccc      780



agttttctac ccatggggcc catactatgg aagatctaga agggatggcc cccgatcctc      840



agctgcttcc acctccatct tctccttctg tctcatcact actcctccat ctgaggccct      900



tccctgtgga ccacaaggga gttttatctg gcgctgaggc acccacacag tcccctggaa      960



ctagccccct ggaagttctc cctggatatg agactcattt ggaaaccaca ggacacaaaa     1020



agatgcccca agcttttgag cctccgatgc cacccccctg ccaatcccca gcttctctgt     1080



cagaacccag aaaagttagc cctgaaggag gacttgctat atctaaggac ttctggggaa     1140



ccgtgggata cagagagaaa cctcaggcct ctgagtcttc aatgccagtc ccttgccctc     1200



ccctagactc cctgccagaa ctccagagag agagttccct ggaagatcca tccagatata     1260



agccccagtg ggaatgcaga gaaaactcag gaaacctctg ggcttttgag tctccagtct     1320



tggacctcaa cccagagctc tctggaacca gccctgaatg tgtcccacca gcatctgaga     1380



caccatggaa gggcatgcaa agtagagaaa atatttgggt ccctgcagac ccagtttcac     1440



ctcccagcct tccctcagtc cctctcctgg agtctctagt aatgggcccc cagggagtcc     1500



tgtctgaatc caaagctttg tgggagacca tggggcagaa agagaacctc tgggcatctg     1560



attccccaga ccctgttcat agcacacctc caaccaccct tatggaacca cacagaatca     1620



atcctgggga atgcctcgct acatcagaag ctacatggaa ggatactgag cattccagga     1680



attcctcggc ttctaggtct ccatctctgg ccctcagccc acccccagct cttgcaccgg     1740



agctgctcag agttagatcc atgggggtcc tgtctgattc tgaagctaga tgtggggaca     1800



tacaaaagac aaaaaactcc tgggcctcta agcacccagc ttgtaactta ccccaagacc     1860



tgcatggagc cagccctctg ggagtcttgt ctgattctca gtctattgta ggggaaatgg     1920



agcaaaaaga aaactgtgtt cctgtgttcc caggtagggg ctccagccca tcctcaaact     1980



ctgtttcaaa gtcccacgta agtgagccta tcgcagacca aagcaactat aagcctgacg     2040



gggaggcagt ggagcaaaga aagaaccact gggccactga gctcccagcc cccagctcac     2100



tctctactcc tctaccagag ccacacattg accttgaact tgtgtggaga aatgtgcaac     2160



aaagagaagt tccccaaggc cccagccctc tggcagtgga tcccctacac ccagtacccc     2220



agcctcccac cctagctgaa gctgtgaaga ttgaacgcac tcatcctggt ctacccaagg     2280



gagtaacgtg cccaggggtt aaggcagagg ccccactctc ccagagatgg actgtcccag     2340



agttgctcac ccatcctggg atccatgcct ggcagtggag tagagagctg aaactcaggc     2400



tgaagaaact gcggcagagc cctgcctcca gagcccctgg cccaagtcaa tcattttgca     2460



gctcccctat tctgagctcc acaattccag acttctgggg actcccttcc tgcccaccac     2520



agcagattta tccccccaat ccatgccccc actcttcaag ttgtcatcct caagaagttc     2580



agcgcacagt acctcagcct gtccagtcct cccactgtca tcacttccaa tcctcttccc     2640



agcttcagcc acaggagtct ggcagggcgg aacaagggtc tcagagaggg gagaaaatga     2700



aggggaagat ggtgagccag gtcccatccc aagggccatg tgtacacatg gaggctggtg     2760



tggactatct atctccaggc ccaggagaac cctcaaactc taaggttctg gtctcaggca     2820



agagaaagga caaggcttca gcctcatcct cagccaaaaa gagagagcac cctaggaaac     2880



ccaaagcagg agaccataga agagggactg caaggttggg gttatccaca gtcacaggga     2940



agaaccaccc tgcccaggcc agaagcctag tagaggcccc tgtaagcaca tttccccaaa     3000



ggtctcaaca caggggccag agctctcaac acactgctct tccccagctg cttctcccca     3060



aagcttcggg tccccaggat cagccagagg cagggcgaag agcaagtgac atcctgaccc     3120



ctcgccactg taagcactgt ccttgggccc acatggagaa gtatctctcc ttccctaccc     3180



tcaaggcttc ccttaccagg ggtttgcaaa aggtgttagc caaatgcctg gataaccatc     3240



gacccctacc caccaaatct agtcagtaga gaaaaggctg gtaatactag cacttggtat     3300



gccaagacct gaagccaaac cagggggaag gtggggatgt ggagacaaga aatggaaatt     3360



ctaataaact agctgaatta gataaatccc aaaaaaaaaa aaaaaa                    3406





<210>  67

<211>  1079

<212>  PRT

<213>  Homo sapiens



<400>  67



Met Glu Trp Leu Leu Glu Asp Leu Leu Gly Ala Lys Gly Asp Met Gly 

1               5                   10                  15      





Leu Leu Trp Gly Gln Leu Thr His Ala Leu Ala Cys Arg His Cys Gly 

            20                  25                  30          





Ser Ser Cys Phe Gln Ser Pro Gly Asn Leu Val Thr Leu Phe Leu Phe 

        35                  40                  45              





Val Val Trp Gln Ile Gln Arg Trp Trp Gln Leu Gly Arg Leu Arg Gln 

    50                  55                  60                  





Leu His Pro Trp Cys Ser Gly Asn Met Val Gln Gly Lys Glu Leu Pro 

65                  70                  75                  80  





Leu Leu His Arg Val Ala Phe Leu Asp His Leu Cys Lys Gln Lys Ser 

                85                  90                  95      





Glu Val Glu Glu Glu Gly Glu Glu Glu Glu Glu Gly Glu Asp Glu Ala 

            100                 105                 110         





Ser Leu Asp Pro Leu Lys Pro Cys Ser Pro Thr Lys Glu Ala Pro Thr 

        115                 120                 125             





Gly Glu Gln Ala Thr Pro Ala Pro Pro Gln Pro Ser Cys Gly Ser Glu 

    130                 135                 140                 





Gly Leu Leu Lys Ala Ile Gly Ile Pro Glu Gln Thr Val Met Gln Pro 

145                 150                 155                 160 





Val Ser Pro Ser Arg Ser Phe Pro Ile Phe Gln Ile Leu Thr Ser Phe 

                165                 170                 175     





Pro Val Arg His Lys Ile Ala Ser Gly Asn Arg Gln Gln Gln Arg Lys 

            180                 185                 190         





Ser Gln Leu Phe Trp Gly Leu Pro Ser Leu His Ser Glu Ser Leu Glu 

        195                 200                 205             





Ala Ile Phe Leu Ser Ser Gly Gly Pro Ser Pro Leu Lys Trp Ser Val 

    210                 215                 220                 





Cys Ser Ser Val Phe Phe Asn Lys Leu Ala Phe Leu Pro Arg Ser Asn 

225                 230                 235                 240 





Leu Leu Leu Pro Gln Tyr His Ser Ser Ala Gln Phe Ser Thr His Gly 

                245                 250                 255     





Ala His Thr Met Glu Asp Leu Glu Gly Met Ala Pro Asp Pro Gln Leu 

            260                 265                 270         





Leu Pro Pro Pro Ser Ser Pro Ser Val Ser Ser Leu Leu Leu His Leu 

        275                 280                 285             





Arg Pro Phe Pro Val Asp His Lys Gly Val Leu Ser Gly Ala Glu Ala 

    290                 295                 300                 





Pro Thr Gln Ser Pro Gly Thr Ser Pro Leu Glu Val Leu Pro Gly Tyr 

305                 310                 315                 320 





Glu Thr His Leu Glu Thr Thr Gly His Lys Lys Met Pro Gln Ala Phe 

                325                 330                 335     





Glu Pro Pro Met Pro Pro Pro Cys Gln Ser Pro Ala Ser Leu Ser Glu 

            340                 345                 350         





Pro Arg Lys Val Ser Pro Glu Gly Gly Leu Ala Ile Ser Lys Asp Phe 

        355                 360                 365             





Trp Gly Thr Val Gly Tyr Arg Glu Lys Pro Gln Ala Ser Glu Ser Ser 

    370                 375                 380                 





Met Pro Val Pro Cys Pro Pro Leu Asp Ser Leu Pro Glu Leu Gln Arg 

385                 390                 395                 400 





Glu Ser Ser Leu Glu Asp Pro Ser Arg Tyr Lys Pro Gln Trp Glu Cys 

                405                 410                 415     





Arg Glu Asn Ser Gly Asn Leu Trp Ala Phe Glu Ser Pro Val Leu Asp 

            420                 425                 430         





Leu Asn Pro Glu Leu Ser Gly Thr Ser Pro Glu Cys Val Pro Pro Ala 

        435                 440                 445             





Ser Glu Thr Pro Trp Lys Gly Met Gln Ser Arg Glu Asn Ile Trp Val 

    450                 455                 460                 





Pro Ala Asp Pro Val Ser Pro Pro Ser Leu Pro Ser Val Pro Leu Leu 

465                 470                 475                 480 





Glu Ser Leu Val Met Gly Pro Gln Gly Val Leu Ser Glu Ser Lys Ala 

                485                 490                 495     





Leu Trp Glu Thr Met Gly Gln Lys Glu Asn Leu Trp Ala Ser Asp Ser 

            500                 505                 510         





Pro Asp Pro Val His Ser Thr Pro Pro Thr Thr Leu Met Glu Pro His 

        515                 520                 525             





Arg Ile Asn Pro Gly Glu Cys Leu Ala Thr Ser Glu Ala Thr Trp Lys 

    530                 535                 540                 





Asp Thr Glu His Ser Arg Asn Ser Ser Ala Ser Arg Ser Pro Ser Leu 

545                 550                 555                 560 





Ala Leu Ser Pro Pro Pro Ala Leu Ala Pro Glu Leu Leu Arg Val Arg 

                565                 570                 575     





Ser Met Gly Val Leu Ser Asp Ser Glu Ala Arg Cys Gly Asp Ile Gln 

            580                 585                 590         





Lys Thr Lys Asn Ser Trp Ala Ser Lys His Pro Ala Cys Asn Leu Pro 

        595                 600                 605             





Gln Asp Leu His Gly Ala Ser Pro Leu Gly Val Leu Ser Asp Ser Gln 

    610                 615                 620                 





Ser Ile Val Gly Glu Met Glu Gln Lys Glu Asn Cys Val Pro Val Phe 

625                 630                 635                 640 





Pro Gly Arg Gly Ser Ser Pro Ser Ser Asn Ser Val Ser Lys Ser His 

                645                 650                 655     





Val Ser Glu Pro Ile Ala Asp Gln Ser Asn Tyr Lys Pro Asp Gly Glu 

            660                 665                 670         





Ala Val Glu Gln Arg Lys Asn His Trp Ala Thr Glu Leu Pro Ala Pro 

        675                 680                 685             





Ser Ser Leu Ser Thr Pro Leu Pro Glu Pro His Ile Asp Leu Glu Leu 

    690                 695                 700                 





Val Trp Arg Asn Val Gln Gln Arg Glu Val Pro Gln Gly Pro Ser Pro 

705                 710                 715                 720 





Leu Ala Val Asp Pro Leu His Pro Val Pro Gln Pro Pro Thr Leu Ala 

                725                 730                 735     





Glu Ala Val Lys Ile Glu Arg Thr His Pro Gly Leu Pro Lys Gly Val 

            740                 745                 750         





Thr Cys Pro Gly Val Lys Ala Glu Ala Pro Leu Ser Gln Arg Trp Thr 

        755                 760                 765             





Val Pro Glu Leu Leu Thr His Pro Gly Ile His Ala Trp Gln Trp Ser 

    770                 775                 780                 





Arg Glu Leu Lys Leu Arg Leu Lys Lys Leu Arg Gln Ser Pro Ala Ser 

785                 790                 795                 800 





Arg Ala Pro Gly Pro Ser Gln Ser Phe Cys Ser Ser Pro Ile Leu Ser 

                805                 810                 815     





Ser Thr Ile Pro Asp Phe Trp Gly Leu Pro Ser Cys Pro Pro Gln Gln 

            820                 825                 830         





Ile Tyr Pro Pro Asn Pro Cys Pro His Ser Ser Ser Cys His Pro Gln 

        835                 840                 845             





Glu Val Gln Arg Thr Val Pro Gln Pro Val Gln Ser Ser His Cys His 

    850                 855                 860                 





His Phe Gln Ser Ser Ser Gln Leu Gln Pro Gln Glu Ser Gly Arg Ala 

865                 870                 875                 880 





Glu Gln Gly Ser Gln Arg Gly Glu Lys Met Lys Gly Lys Met Val Ser 

                885                 890                 895     





Gln Val Pro Ser Gln Gly Pro Cys Val His Met Glu Ala Gly Val Asp 

            900                 905                 910         





Tyr Leu Ser Pro Gly Pro Gly Glu Pro Ser Asn Ser Lys Val Leu Val 

        915                 920                 925             





Ser Gly Lys Arg Lys Asp Lys Ala Ser Ala Ser Ser Ser Ala Lys Lys 

    930                 935                 940                 





Arg Glu His Pro Arg Lys Pro Lys Ala Gly Asp His Arg Arg Gly Thr 

945                 950                 955                 960 





Ala Arg Leu Gly Leu Ser Thr Val Thr Gly Lys Asn His Pro Ala Gln 

                965                 970                 975     





Ala Arg Ser Leu Val Glu Ala Pro Val Ser Thr Phe Pro Gln Arg Ser 

            980                 985                 990         





Gln His Arg Gly Gln Ser Ser Gln  His Thr Ala Leu Pro  Gln Leu Leu 

        995                 1000                 1005             





Leu Pro  Lys Ala Ser Gly Pro  Gln Asp Gln Pro Glu  Ala Gly Arg 

    1010                 1015                 1020             





Arg Ala  Ser Asp Ile Leu Thr  Pro Arg His Cys Lys  His Cys Pro 

    1025                 1030                 1035             





Trp Ala  His Met Glu Lys Tyr  Leu Ser Phe Pro Thr  Leu Lys Ala 

    1040                 1045                 1050             





Ser Leu  Thr Arg Gly Leu Gln  Lys Val Leu Ala Lys  Cys Leu Asp 

    1055                 1060                 1065             





Asn His  Arg Pro Leu Pro Thr  Lys Ser Ser Gln 

    1070                 1075                 





<210>  68

<211>  1266

<212>  DNA

<213>  Homo sapiens



<400>  68

cggcttgtca cctgccctag gagacgcagc cgccggaccc tgcccagggc acccacgcct       60



cggcgaccac catgtcccag accaaaatgc tgaaggtccg cgtgaccctc ttctgcatcc      120



tggcaggcat cgtgctggcc atgacagccg tggtaaccga ccactgggct gtgctgagcc      180



cccacatgga gcaccacaac actacctgcg aggcggccca cttcggcctc tggcggattt      240



gtaccaagcg catccccatg gacgacagca agacctgcgg gcccatcacc ctgcccgggg      300



agaagaactg ttcctacttc aggcatttta accccggcga gagctcggag atcttcgaat      360



tcaccactca gaaggagtac agcatctcgg cagccgccat cgccatcttc agccttggct      420



tcatcatcct gggcagcctc tgtgtcctcc tgtccctcgg gaagaagagg gactatctgc      480



tgcgacccgc gtccatgttc tatgcctttg caggtctctg catcctcgtc tcggtggagg      540



tcatgcggca gtcggtgaag cgcatgattg acagtgagga caccgtctgg atcgagtact      600



attactcctg gtcctttgcc tgcgcctgtg ccgccttcat cctcctcttt ctcggcggtc      660



tcgccctcct gctgttctcc ctgcctcgaa tgccccggaa cccatgggag tcctgcatgg      720



atgctgagcc cgagcactaa ccctcctgcg gccctagcga ccctcaggct tcttccccag      780



gaagcggggt cttggcctgg aaccttccag agaggaggcg ggagcaattt tagccccacc      840



ctgctcccat ctgcccccct gcaacagtcg caggctgctt cctctctctg agttcctctg      900



ggctgccgca ggctcccctg ggaatagagc aagacgtgag tcctaacctg gccacagttg      960



ggggaggcag agccagcagg tggacaggtg tttgcagggg cccaacttcc cctggagctc     1020



agaggtgtcc ccactgtacc agcctctgat aagctgcctc cagttgtcct ttatgaacat     1080



tgcagggaca acctgtgttt gccagctggg tgttccgtgt aaatagccag cctgtctctt     1140



tctcggtgat aaaacacacc ctctctggtg agcccagcgt cccctccttg gcttccagga     1200



gccctgggaa gcatttttaa ctgggtagaa tctgactgtg gcttgaaata aaaagctctc     1260



agaaaa                                                                1266





<210>  69

<211>  222

<212>  PRT

<213>  Homo sapiens



<400>  69



Met Ser Gln Thr Lys Met Leu Lys Val Arg Val Thr Leu Phe Cys Ile 

1               5                   10                  15      





Leu Ala Gly Ile Val Leu Ala Met Thr Ala Val Val Thr Asp His Trp 

            20                  25                  30          





Ala Val Leu Ser Pro His Met Glu His His Asn Thr Thr Cys Glu Ala 

        35                  40                  45              





Ala His Phe Gly Leu Trp Arg Ile Cys Thr Lys Arg Ile Pro Met Asp 

    50                  55                  60                  





Asp Ser Lys Thr Cys Gly Pro Ile Thr Leu Pro Gly Glu Lys Asn Cys 

65                  70                  75                  80  





Ser Tyr Phe Arg His Phe Asn Pro Gly Glu Ser Ser Glu Ile Phe Glu 

                85                  90                  95      





Phe Thr Thr Gln Lys Glu Tyr Ser Ile Ser Ala Ala Ala Ile Ala Ile 

            100                 105                 110         





Phe Ser Leu Gly Phe Ile Ile Leu Gly Ser Leu Cys Val Leu Leu Ser 

        115                 120                 125             





Leu Gly Lys Lys Arg Asp Tyr Leu Leu Arg Pro Ala Ser Met Phe Tyr 

    130                 135                 140                 





Ala Phe Ala Gly Leu Cys Ile Leu Val Ser Val Glu Val Met Arg Gln 

145                 150                 155                 160 





Ser Val Lys Arg Met Ile Asp Ser Glu Asp Thr Val Trp Ile Glu Tyr 

                165                 170                 175     





Tyr Tyr Ser Trp Ser Phe Ala Cys Ala Cys Ala Ala Phe Ile Leu Leu 

            180                 185                 190         





Phe Leu Gly Gly Leu Ala Leu Leu Leu Phe Ser Leu Pro Arg Met Pro 

        195                 200                 205             





Arg Asn Pro Trp Glu Ser Cys Met Asp Ala Glu Pro Glu His 

    210                 215                 220         





<210>  70

<211>  3568

<212>  DNA

<213>  Homo sapiens



<400>  70

atagttttca ggttaagaaa gccagaatct ttgttcagcc acactgactg aacagacttt       60



tagtggggtt acctggctaa cagcagcagc ggcaacggca gcagcagcag cagcagcagc      120



agcagcagca gcagggctcc tgggataact caggcatagt tcaacactat gggtcctcct      180



ctgaagctct tcaaaaacca gaaataccag gaactgaagc aggaatgcat caaagacagc      240



agacttttct gtgatccaac atttctgcct gagaatgatt ctcttttcta caaccgactg      300



cttcctggaa aggtggtgtg gaaacgtccc caggacatct gtgatgaccc ccatctgatt      360



gtgggcaaca ttagcaacca ccagctgacc caagggagac tggggcacaa gccaatggtt      420



tctgcatttt cctgtttggc tgttcaggag tctcattgga caaagacaat tcccaaccat      480



aaggaacagg aatgggaccc tcaaaaaaca gaaaaatacg ctgggatatt tcactttcgt      540



ttctggcatt ttggagaatg gactgaagtg gtgattgatg acttgttgcc caccattaac      600



ggagatctgg tcttctcttt ctccacttcc atgaatgagt tttggaatgc tctgctggaa      660



aaagcttatg caaagctgct aggctgttat gaggccctgg atggtttgac catcactgat      720



attattgtgg acttcacggg cacattggct gaaactgttg acatgcagaa aggaagatac      780



actgagcttg ttgaggagaa gtacaagcta ttcggagaac tgtacaaaac atttaccaaa      840



ggtggtctga tctgctgttc cattgagtct cccaatcagg aggagcaaga agttgaaact      900



gattggggtc tgctgaaggg ccatacctat accatgactg atattcgcaa aattcgtctt      960



ggagagagac ttgtggaagt cttcagtgct gagaaggtgt atatggttcg cctgagaaac     1020



cccttgggaa gacaggaatg gagtggcccc tggagtgaaa tttctgaaga gtggcagcaa     1080



ctgactgcat cagatcgcaa gaacctgggg cttgttatgt ctgatgatgg agagttttgg     1140



atgagcttgg aggacttttg ccgcaacttt cacaaactga atgtctgccg caatgtgaac     1200



aaccctattt ttggccgaaa ggagctggaa tcggtgttgg gatgctggac tgtggatgat     1260



gatcccctga tgaaccgctc aggaggctgc tataacaacc gtgatacctt cctgcagaat     1320



ccccagtaca tcttcactgt gcctgaggat gggcacaagg tcattatgtc actgcagcag     1380



aaggacctgc gcacttaccg ccgaatggga agacctgaca attacatcat tggctttgag     1440



ctcttcaagg tggagatgaa ccgcaaattc cgcctccacc acctctacat ccaggagcgt     1500



gctgggactt ccacctatat tgacacccgc acagtgtttc tgagcaagta cctgaagaag     1560



ggcaactatg tgcttgtccc aaccatgttc cagcatggtc gcaccagcga gtttctcctg     1620



agaatcttct ctgaagtgcc tgtccagctc agggaactga ctctggacat gcccaaaatg     1680



tcctgctgga acctggctcg tggctacccg aaagtagtta ctcagatcac tgttcacagt     1740



gctgaggacc tggagaagaa gtatgccaat gaaactgtaa acccatattt ggtcatcaaa     1800



tgtggaaagg aggaagtccg ttctcctgtc cagaagaata cagttcatgc catttttgac     1860



acccaggcca ttttctacag aaggaccact gacattccta ttatagtaca ggtctggaac     1920



agccgaaaat tctgtgatca gttcttgggg caggttactc tggatgctga ccccagcgac     1980



tgccgtgatc tgaagtctct gtacctgcgt aagaagggtg gtccaactgc caaagtcaag     2040



caaggccaca tcagcttcaa ggttatttcc agcgatgatc tcactgagct ctaaatctgc     2100



aatcccagag aatcctgaca aagcgtgcca cccttttatt ttccgtcagg tgccaggtct     2160



tagttaagat tcacaatctt tagaaagaat gagattcaca ataattaact cttcctctct     2220



tctgataaat tccccatacc tcccaatcca agtagcatct gtagctacat aacctatata     2280



cctccagcag ctggacatgg ggaggcgaca gtcctatcta gacatcatac acatttgcca     2340



agaaaggatc tctggggctt ccgggggtga gattcaagca ggacaataac aagaggctgg     2400



acaccctaca gatgtctttg atgttttcag ttgtttgata tatctcccct gtagggcatg     2460



ttgaggaagg aggagggctg atcaaggcca agctggtcta gcctgacatc ctagctcctg     2520



actgaacact atagacttcc cagcagcatt tcacccagca gccagagccg gctttaagtc     2580



cccaaccctt acagacacca ctgccaccac caccaaccac gaccaccacc accaccacca     2640



ctcaccacca tcatcacctc cggaaagtgt agtcctgccc taacccaagt cacccccgac     2700



agtaaatttt accttcatgt tgagaaagct tcctggtgct taatcaagag ctggagttca     2760



atgagtccta gacagtgaga ggggcctgag cttcagctca atggaagcct gctgtgtgcc     2820



acaagacgga aaagtggaag aagctgcagt gggagacaaa gcctcggtcc cccacccatc     2880



cacacacacc tacactcaca cacgcgcaca tgggcgcgca cgaactacca ttcaggcagt     2940



cagtgggcaa gaggaaagat aagtaagtac catacacacc taaaagatga gagaattcat     3000



ccagacatat tacagccagt ttggggcccc tgactgcaat gtgaaacctc tcgctgctgc     3060



taggtttaca aacaagccca ttgtcctgtg cctcctaata tcatttgtac tgaagacccc     3120



atctggggac ttgagacttt ggtcccagcc cagactcctc agacttttct ctcagttggg     3180



atgcttcact cgctgggggt gtttgtttgc cctctcattt ttcagtactt ctacagaatt     3240



ttctctagag tcagtcatta tgaaatgtac ttccctccat cttaacctat caactttctg     3300



cccctccttc aaggcccagt ataaatgcca cctcctccat gaagccttcc ctaattccac     3360



cccaaacccc caccttcaac aatatttcaa cgcttctgca atgatgaaaa agaaacatag     3420



ttgtagtact tagcctacct agaccagcaa gcattcattt ttagctcgct cattttttac     3480



catgttttcc agtctgttta acttctgcag tgccttcact acactgcctt acataaacca     3540



aatcacaata aagttcatat tcagtaca                                        3568





<210>  71

<211>  641

<212>  PRT

<213>  Homo sapiens



<400>  71



Met Gly Pro Pro Leu Lys Leu Phe Lys Asn Gln Lys Tyr Gln Glu Leu 

1               5                   10                  15      





Lys Gln Glu Cys Ile Lys Asp Ser Arg Leu Phe Cys Asp Pro Thr Phe 

            20                  25                  30          





Leu Pro Glu Asn Asp Ser Leu Phe Tyr Asn Arg Leu Leu Pro Gly Lys 

        35                  40                  45              





Val Val Trp Lys Arg Pro Gln Asp Ile Cys Asp Asp Pro His Leu Ile 

    50                  55                  60                  





Val Gly Asn Ile Ser Asn His Gln Leu Thr Gln Gly Arg Leu Gly His 

65                  70                  75                  80  





Lys Pro Met Val Ser Ala Phe Ser Cys Leu Ala Val Gln Glu Ser His 

                85                  90                  95      





Trp Thr Lys Thr Ile Pro Asn His Lys Glu Gln Glu Trp Asp Pro Gln 

            100                 105                 110         





Lys Thr Glu Lys Tyr Ala Gly Ile Phe His Phe Arg Phe Trp His Phe 

        115                 120                 125             





Gly Glu Trp Thr Glu Val Val Ile Asp Asp Leu Leu Pro Thr Ile Asn 

    130                 135                 140                 





Gly Asp Leu Val Phe Ser Phe Ser Thr Ser Met Asn Glu Phe Trp Asn 

145                 150                 155                 160 





Ala Leu Leu Glu Lys Ala Tyr Ala Lys Leu Leu Gly Cys Tyr Glu Ala 

                165                 170                 175     





Leu Asp Gly Leu Thr Ile Thr Asp Ile Ile Val Asp Phe Thr Gly Thr 

            180                 185                 190         





Leu Ala Glu Thr Val Asp Met Gln Lys Gly Arg Tyr Thr Glu Leu Val 

        195                 200                 205             





Glu Glu Lys Tyr Lys Leu Phe Gly Glu Leu Tyr Lys Thr Phe Thr Lys 

    210                 215                 220                 





Gly Gly Leu Ile Cys Cys Ser Ile Glu Ser Pro Asn Gln Glu Glu Gln 

225                 230                 235                 240 





Glu Val Glu Thr Asp Trp Gly Leu Leu Lys Gly His Thr Tyr Thr Met 

                245                 250                 255     





Thr Asp Ile Arg Lys Ile Arg Leu Gly Glu Arg Leu Val Glu Val Phe 

            260                 265                 270         





Ser Ala Glu Lys Val Tyr Met Val Arg Leu Arg Asn Pro Leu Gly Arg 

        275                 280                 285             





Gln Glu Trp Ser Gly Pro Trp Ser Glu Ile Ser Glu Glu Trp Gln Gln 

    290                 295                 300                 





Leu Thr Ala Ser Asp Arg Lys Asn Leu Gly Leu Val Met Ser Asp Asp 

305                 310                 315                 320 





Gly Glu Phe Trp Met Ser Leu Glu Asp Phe Cys Arg Asn Phe His Lys 

                325                 330                 335     





Leu Asn Val Cys Arg Asn Val Asn Asn Pro Ile Phe Gly Arg Lys Glu 

            340                 345                 350         





Leu Glu Ser Val Leu Gly Cys Trp Thr Val Asp Asp Asp Pro Leu Met 

        355                 360                 365             





Asn Arg Ser Gly Gly Cys Tyr Asn Asn Arg Asp Thr Phe Leu Gln Asn 

    370                 375                 380                 





Pro Gln Tyr Ile Phe Thr Val Pro Glu Asp Gly His Lys Val Ile Met 

385                 390                 395                 400 





Ser Leu Gln Gln Lys Asp Leu Arg Thr Tyr Arg Arg Met Gly Arg Pro 

                405                 410                 415     





Asp Asn Tyr Ile Ile Gly Phe Glu Leu Phe Lys Val Glu Met Asn Arg 

            420                 425                 430         





Lys Phe Arg Leu His His Leu Tyr Ile Gln Glu Arg Ala Gly Thr Ser 

        435                 440                 445             





Thr Tyr Ile Asp Thr Arg Thr Val Phe Leu Ser Lys Tyr Leu Lys Lys 

    450                 455                 460                 





Gly Asn Tyr Val Leu Val Pro Thr Met Phe Gln His Gly Arg Thr Ser 

465                 470                 475                 480 





Glu Phe Leu Leu Arg Ile Phe Ser Glu Val Pro Val Gln Leu Arg Glu 

                485                 490                 495     





Leu Thr Leu Asp Met Pro Lys Met Ser Cys Trp Asn Leu Ala Arg Gly 

            500                 505                 510         





Tyr Pro Lys Val Val Thr Gln Ile Thr Val His Ser Ala Glu Asp Leu 

        515                 520                 525             





Glu Lys Lys Tyr Ala Asn Glu Thr Val Asn Pro Tyr Leu Val Ile Lys 

    530                 535                 540                 





Cys Gly Lys Glu Glu Val Arg Ser Pro Val Gln Lys Asn Thr Val His 

545                 550                 555                 560 





Ala Ile Phe Asp Thr Gln Ala Ile Phe Tyr Arg Arg Thr Thr Asp Ile 

                565                 570                 575     





Pro Ile Ile Val Gln Val Trp Asn Ser Arg Lys Phe Cys Asp Gln Phe 

            580                 585                 590         





Leu Gly Gln Val Thr Leu Asp Ala Asp Pro Ser Asp Cys Arg Asp Leu 

        595                 600                 605             





Lys Ser Leu Tyr Leu Arg Lys Lys Gly Gly Pro Thr Ala Lys Val Lys 

    610                 615                 620                 





Gln Gly His Ile Ser Phe Lys Val Ile Ser Ser Asp Asp Leu Thr Glu 

625                 630                 635                 640 





Leu 

    





<210>  72

<211>  2568

<212>  DNA

<213>  Homo sapiens



<400>  72

gggaagatac acggttttta agaaagaact tctaacccca ctccaccgcc caacggtcac       60



gtgacgcgcc tgcgtcctcg cctcaaggtt ttttctggtc gcatattggc tgttaactcg      120



gctacggggt gtagcgaggt gcattccgga agtaggtcct ttgacttttg cttcctctac      180



ggaggcaagt aacaacccgg cggtcgacgc ttagcggaag ttcgtcaagt cgcagttgcc      240



cccgcacagc ggatgtgggt cgcctcttag gtgacgctgg gaagtgcctg caaccttcgc      300



cgctgccttc tggttgaagc actatggagg gagagaggaa gaacaacaac aaacggtggt      360



atttcactcg agaacagctg gaaaatagcc catcccgtcg ttttggcgtg gacccagata      420



aagaactttc ttatcgccag caggcggcca atctgcttca ggacatgggg cagcgtctta      480



acgtctcaca attgactatc aacactgcta tagtatacat gcatcgattc tacatgattc      540



agtccttcac acagttccct ggaaattctg tggctccagc agccttgttt ctagcagcta      600



aagtggagga gcagcccaaa aaattggaac atgtcatcaa ggtagcacat acttgtctcc      660



atcctcagga atcccttcct gatactagaa gtgaggctta tttgcaacaa gttcaagatc      720



tggtcatttt agaaagcata attttgcaga ctttaggctt tgaactaaca attgatcacc      780



cacatactca tgtagtaaag tgcactcaac ttgttcgagc aagcaaggac ttagcacaga      840



cttcttactt catggcaacc aacagcctgc atttgaccac atttagcctg cagtacacac      900



ctcctgtggt ggcctgtgtc tgcattcacc tggcttgcaa gtggtccaat tgggagatcc      960



cagtctcaac tgacgggaag cactggtggg agtatgttga cgccactgtg accttggaac     1020



ttttagatga actgacacat gagtttctac agattttgga gaaaactccc aacaggctca     1080



aacgcatttg gaattggagg gcatgcgagg ctgccaagaa aacaaaagca gatgaccgag     1140



gaacagatga aaagacttca gagcagacaa tcctcaatat gatttcccag agctcttcag     1200



acacaaccat tgcaggttta atgagcatgt caacttctac cacaagtgca gtgccttccc     1260



tgccagtctc cgaagagtca tccagcaact taaccagtgt ggagatgttg ccgggcaagc     1320



gttggctgtc ctcccaacct tctttcaaac tagaacctac tcagggtcat cggactagtg     1380



agaatttagc acttacagga gttgatcatt ccttaccaca ggatggttca aatgcattta     1440



tttcccagaa gcagaatagt aagagtgtgc catcagctaa agtgtcactg aaagaatacc     1500



gcgcgaagca tgcagaagaa ttggctgccc agaagaggca actggagaac atggaagcca     1560



atgtgaagtc acaatatgca tatgctgccc agaatctcct ttctcatcat gatagccatt     1620



cttcagtcat tctaaaaatg cccatagagg gttcagaaaa ccccgagcgg ccttttctgg     1680



aaaaggctga caaaacagct ctcaaaatga gaatcccagt ggcaggtgga gataaagctg     1740



cgtcttcaaa accagaggag ataaaaatgc gcataaaagt ccatgctgca gctgataagc     1800



acaattctgt agaggacagt gttacaaaga gccgagagca caaagaaaag cacaagactc     1860



acccatctaa tcatcatcat catcataatc accactcaca caagcactct cattcccaac     1920



ttccagttgg tactgggaac aaacgtcctg gtgatccaaa acatagtagc cagacaagca     1980



acttagcaca taaaacctat agcttgtcta gttctttttc ctcttccagt tctactcgta     2040



aaaggggacc ctctgaagag actggagggg ctgtgtttga tcatccagcc aagattgcca     2100



agagtactaa atcctcttcc ctaaatttct ccttcccttc acttcctaca atgggtcaga     2160



tgcctgggca tagctcagac acaagtggcc tttccttttc acagcccagc tgtaaaactc     2220



gtgtccctca ttcgaaactg gataaagggc ccactggggc caatggtcac aacacgaccc     2280



agacaataga ctatcaagac actgtgaata tgcttcactc cctgctcagt gcccagggtg     2340



ttcagcccac tcagcccact gcatttgaat ttgttcgtcc ttatagtgac tatctgaatc     2400



ctcggtctgg tggaatctcc tcgagatctg gcaatacaga caaaccccgg ccaccacctc     2460



tgccatcaga acctcctcca ccacttccac cccttcctaa gtaaaaaaag aaaaagaaga     2520



ggagaaaaaa acttctttaa aaaaacacat aatttttctt tttttttt                  2568





<210>  73

<211>  726

<212>  PRT

<213>  Homo sapiens



<400>  73



Met Glu Gly Glu Arg Lys Asn Asn Asn Lys Arg Trp Tyr Phe Thr Arg 

1               5                   10                  15      





Glu Gln Leu Glu Asn Ser Pro Ser Arg Arg Phe Gly Val Asp Pro Asp 

            20                  25                  30          





Lys Glu Leu Ser Tyr Arg Gln Gln Ala Ala Asn Leu Leu Gln Asp Met 

        35                  40                  45              





Gly Gln Arg Leu Asn Val Ser Gln Leu Thr Ile Asn Thr Ala Ile Val 

    50                  55                  60                  





Tyr Met His Arg Phe Tyr Met Ile Gln Ser Phe Thr Gln Phe Pro Gly 

65                  70                  75                  80  





Asn Ser Val Ala Pro Ala Ala Leu Phe Leu Ala Ala Lys Val Glu Glu 

                85                  90                  95      





Gln Pro Lys Lys Leu Glu His Val Ile Lys Val Ala His Thr Cys Leu 

            100                 105                 110         





His Pro Gln Glu Ser Leu Pro Asp Thr Arg Ser Glu Ala Tyr Leu Gln 

        115                 120                 125             





Gln Val Gln Asp Leu Val Ile Leu Glu Ser Ile Ile Leu Gln Thr Leu 

    130                 135                 140                 





Gly Phe Glu Leu Thr Ile Asp His Pro His Thr His Val Val Lys Cys 

145                 150                 155                 160 





Thr Gln Leu Val Arg Ala Ser Lys Asp Leu Ala Gln Thr Ser Tyr Phe 

                165                 170                 175     





Met Ala Thr Asn Ser Leu His Leu Thr Thr Phe Ser Leu Gln Tyr Thr 

            180                 185                 190         





Pro Pro Val Val Ala Cys Val Cys Ile His Leu Ala Cys Lys Trp Ser 

        195                 200                 205             





Asn Trp Glu Ile Pro Val Ser Thr Asp Gly Lys His Trp Trp Glu Tyr 

    210                 215                 220                 





Val Asp Ala Thr Val Thr Leu Glu Leu Leu Asp Glu Leu Thr His Glu 

225                 230                 235                 240 





Phe Leu Gln Ile Leu Glu Lys Thr Pro Asn Arg Leu Lys Arg Ile Trp 

                245                 250                 255     





Asn Trp Arg Ala Cys Glu Ala Ala Lys Lys Thr Lys Ala Asp Asp Arg 

            260                 265                 270         





Gly Thr Asp Glu Lys Thr Ser Glu Gln Thr Ile Leu Asn Met Ile Ser 

        275                 280                 285             





Gln Ser Ser Ser Asp Thr Thr Ile Ala Gly Leu Met Ser Met Ser Thr 

    290                 295                 300                 





Ser Thr Thr Ser Ala Val Pro Ser Leu Pro Val Ser Glu Glu Ser Ser 

305                 310                 315                 320 





Ser Asn Leu Thr Ser Val Glu Met Leu Pro Gly Lys Arg Trp Leu Ser 

                325                 330                 335     





Ser Gln Pro Ser Phe Lys Leu Glu Pro Thr Gln Gly His Arg Thr Ser 

            340                 345                 350         





Glu Asn Leu Ala Leu Thr Gly Val Asp His Ser Leu Pro Gln Asp Gly 

        355                 360                 365             





Ser Asn Ala Phe Ile Ser Gln Lys Gln Asn Ser Lys Ser Val Pro Ser 

    370                 375                 380                 





Ala Lys Val Ser Leu Lys Glu Tyr Arg Ala Lys His Ala Glu Glu Leu 

385                 390                 395                 400 





Ala Ala Gln Lys Arg Gln Leu Glu Asn Met Glu Ala Asn Val Lys Ser 

                405                 410                 415     





Gln Tyr Ala Tyr Ala Ala Gln Asn Leu Leu Ser His His Asp Ser His 

            420                 425                 430         





Ser Ser Val Ile Leu Lys Met Pro Ile Glu Gly Ser Glu Asn Pro Glu 

        435                 440                 445             





Arg Pro Phe Leu Glu Lys Ala Asp Lys Thr Ala Leu Lys Met Arg Ile 

    450                 455                 460                 





Pro Val Ala Gly Gly Asp Lys Ala Ala Ser Ser Lys Pro Glu Glu Ile 

465                 470                 475                 480 





Lys Met Arg Ile Lys Val His Ala Ala Ala Asp Lys His Asn Ser Val 

                485                 490                 495     





Glu Asp Ser Val Thr Lys Ser Arg Glu His Lys Glu Lys His Lys Thr 

            500                 505                 510         





His Pro Ser Asn His His His His His Asn His His Ser His Lys His 

        515                 520                 525             





Ser His Ser Gln Leu Pro Val Gly Thr Gly Asn Lys Arg Pro Gly Asp 

    530                 535                 540                 





Pro Lys His Ser Ser Gln Thr Ser Asn Leu Ala His Lys Thr Tyr Ser 

545                 550                 555                 560 





Leu Ser Ser Ser Phe Ser Ser Ser Ser Ser Thr Arg Lys Arg Gly Pro 

                565                 570                 575     





Ser Glu Glu Thr Gly Gly Ala Val Phe Asp His Pro Ala Lys Ile Ala 

            580                 585                 590         





Lys Ser Thr Lys Ser Ser Ser Leu Asn Phe Ser Phe Pro Ser Leu Pro 

        595                 600                 605             





Thr Met Gly Gln Met Pro Gly His Ser Ser Asp Thr Ser Gly Leu Ser 

    610                 615                 620                 





Phe Ser Gln Pro Ser Cys Lys Thr Arg Val Pro His Ser Lys Leu Asp 

625                 630                 635                 640 





Lys Gly Pro Thr Gly Ala Asn Gly His Asn Thr Thr Gln Thr Ile Asp 

                645                 650                 655     





Tyr Gln Asp Thr Val Asn Met Leu His Ser Leu Leu Ser Ala Gln Gly 

            660                 665                 670         





Val Gln Pro Thr Gln Pro Thr Ala Phe Glu Phe Val Arg Pro Tyr Ser 

        675                 680                 685             





Asp Tyr Leu Asn Pro Arg Ser Gly Gly Ile Ser Ser Arg Ser Gly Asn 

    690                 695                 700                 





Thr Asp Lys Pro Arg Pro Pro Pro Leu Pro Ser Glu Pro Pro Pro Pro 

705                 710                 715                 720 





Leu Pro Pro Leu Pro Lys 

                725     





<210>  74

<211>  2751

<212>  DNA

<213>  Homo sapiens



<400>  74

gggagcttcc ggattgagcc ggaagtcccc ccagagcgga tgccgcggcg ggcctgtggg       60



agcggggtca tcttctctct gctgctgtag ctgccatggg caaaagagac cgagcggacc      120



gcgacaagaa gaaatccagg aagcggcact atgaggatga agaggatgat gaagaggacg      180



ccccggggaa cgaccctcag gaagcggttc cctcggcggc ggggaagcag gtggatgagt      240



caggcaccaa agtggatgaa tatggagcca aggactacag gctgcaaatg ccgctgaagg      300



acgaccacac ctccaggccc ctctgggtgg ctcccgatgg ccatatcttc ttggaagcct      360



tctctccagt ttacaaatat gcccaagact tcttggtggc tattgcagag ccagtgtgcc      420



gaccaaccca tgtgcatgag tacaaactaa ctgcctactc cttgtatgca gctgtcagcg      480



ttgggctgca aaccagtgac atcaccgagt acctcaggaa gctcagcaag actggagtcc      540



ctgatggaat tatgcagttt attaagttgt gtactgtcag ctatggaaaa gtcaagctgg      600



tcttgaagca caacagatac ttcgttgaaa gttgccaccc tgatgtaatc cagcatcttc      660



tccaggaccc cgtgatccga gaatgccgct taagaaactc tgaaggggag gccactgagc      720



tcatcacaga gactttcaca agcaaatctg ccatttctaa gactgctgaa agcagtggtg      780



ggccctccac ttcccgagtg acagatccac agggtaaatc tgacatcccc atggacctgt      840



ttgacttcta tgagcaaatg gacaaggatg aagaagaaga agaagagaca cagacagtgt      900



cttttgaagt caagcaggaa atgattgagg aactccagaa acgttgcatc cacctggagt      960



accctctgtt ggcagaatat gacttccgga atgattctgt caaccctgat atcaacattg     1020



acctaaagcc cacagctgtc ctcagaccct atcaggagaa gagcttgcga aagatgtttg     1080



gaaacgggcg tgcacgttcg ggggtcattg ttcttccctg cggtgctgga aagtccctgg     1140



ttggtgtgac tgctgcatgc actgtcagaa aacgctgtct ggtgctgggc aactcagctg     1200



tttctgtgga gcagtggaaa gcccagttca agatgtggtc caccattgac gacagccaga     1260



tctgccggtt cacctccgat gccaaggaca agcccatcgg ctgctccgtt gccattagca     1320



cctactccat gctgggccac accaccaaaa ggtcctggga ggccgagcga gtcatggagt     1380



ggctcaagac ccaggagtgg ggcctcatga tcctggatga agtgcacacc ataccagcca     1440



agatgttccg aagggtgctc accatcgtgc aggcccactg taagctgggt ttgactgcga     1500



ccctcgtccg cgaagatgac aaaattgtgg atttaaattt tctgattggg cctaagctct     1560



acgaagccaa ctggatggag ctgcagaata atggctacat cgccaaagtc cagtgtgctg     1620



aggtctggtg ccctatgtct cctgaatttt accgggaata tgtggcaatc aaaaccaaga     1680



aacgaatctt gctgtacacc atgaacccca acaaatttag agcttgccag tttctgatca     1740



agtttcatga aaggaggaat gacaagatta ttgtctttgc tgacaatgtg tttgccctaa     1800



aggaatatgc cattcgactg aacaaaccct atatctacgg acctacgtct cagggggaaa     1860



ggatgcaaat tctccagaat ttcaagcaca accccaaaat taacaccatc ttcatatcca     1920



aggtaggtga cacttcgttt gatctgccgg aagcaaatgt cctcattcag atctcatccc     1980



atggtggctc caggcgtcag gaagcccaaa ggctagggcg ggtgcttcga gctaaaaaag     2040



ggatggttgc agaagagtac aatgcctttt tctactcact ggtatcccag gacacacagg     2100



aaatggctta ctcaaccaag cggcagagat tcttggtaga tcaaggttat agcttcaagg     2160



tgatcacgaa actcgctggc atggaggagg aagacttggc gttttcgaca aaagaagagc     2220



aacagcagct cttacagaaa gtcctggcag ccactgacct ggatgccgag gaggaggtgg     2280



tggctgggga atttggctcc agatccagcc aggcatctcg gcgctttggc accatgagtt     2340



ctatgtctgg ggccgacgac actgtgtaca tggagtacca ctcatcgcgg agcaaggcgc     2400



ccagcaaaca tgtacacccg ctcttcaagc gctttaggaa atgatgctta ggcagggtac     2460



ttcgttcaag accggcgctt ggcacccttg ttggaaaggg attttcagca taacattttc     2520



cttccacctc tttgaccttc cctccagcgt tggccaaatt gtgctgagga agatgcatca     2580



agggcttggc tgtgccttca taggtcatct agggttttat aaaggaggag gagacaatat     2640



tttttcaaac tttttgggga gtggggtcat ttctgtatat aaaaaatgtt aatatttaag     2700



gtgtatttat gttaccgttc tgaataaaca gaatggacca ttgaaccagt a              2751





<210>  75

<211>  782

<212>  PRT

<213>  Homo sapiens



<400>  75



Met Gly Lys Arg Asp Arg Ala Asp Arg Asp Lys Lys Lys Ser Arg Lys 

1               5                   10                  15      





Arg His Tyr Glu Asp Glu Glu Asp Asp Glu Glu Asp Ala Pro Gly Asn 

            20                  25                  30          





Asp Pro Gln Glu Ala Val Pro Ser Ala Ala Gly Lys Gln Val Asp Glu 

        35                  40                  45              





Ser Gly Thr Lys Val Asp Glu Tyr Gly Ala Lys Asp Tyr Arg Leu Gln 

    50                  55                  60                  





Met Pro Leu Lys Asp Asp His Thr Ser Arg Pro Leu Trp Val Ala Pro 

65                  70                  75                  80  





Asp Gly His Ile Phe Leu Glu Ala Phe Ser Pro Val Tyr Lys Tyr Ala 

                85                  90                  95      





Gln Asp Phe Leu Val Ala Ile Ala Glu Pro Val Cys Arg Pro Thr His 

            100                 105                 110         





Val His Glu Tyr Lys Leu Thr Ala Tyr Ser Leu Tyr Ala Ala Val Ser 

        115                 120                 125             





Val Gly Leu Gln Thr Ser Asp Ile Thr Glu Tyr Leu Arg Lys Leu Ser 

    130                 135                 140                 





Lys Thr Gly Val Pro Asp Gly Ile Met Gln Phe Ile Lys Leu Cys Thr 

145                 150                 155                 160 





Val Ser Tyr Gly Lys Val Lys Leu Val Leu Lys His Asn Arg Tyr Phe 

                165                 170                 175     





Val Glu Ser Cys His Pro Asp Val Ile Gln His Leu Leu Gln Asp Pro 

            180                 185                 190         





Val Ile Arg Glu Cys Arg Leu Arg Asn Ser Glu Gly Glu Ala Thr Glu 

        195                 200                 205             





Leu Ile Thr Glu Thr Phe Thr Ser Lys Ser Ala Ile Ser Lys Thr Ala 

    210                 215                 220                 





Glu Ser Ser Gly Gly Pro Ser Thr Ser Arg Val Thr Asp Pro Gln Gly 

225                 230                 235                 240 





Lys Ser Asp Ile Pro Met Asp Leu Phe Asp Phe Tyr Glu Gln Met Asp 

                245                 250                 255     





Lys Asp Glu Glu Glu Glu Glu Glu Thr Gln Thr Val Ser Phe Glu Val 

            260                 265                 270         





Lys Gln Glu Met Ile Glu Glu Leu Gln Lys Arg Cys Ile His Leu Glu 

        275                 280                 285             





Tyr Pro Leu Leu Ala Glu Tyr Asp Phe Arg Asn Asp Ser Val Asn Pro 

    290                 295                 300                 





Asp Ile Asn Ile Asp Leu Lys Pro Thr Ala Val Leu Arg Pro Tyr Gln 

305                 310                 315                 320 





Glu Lys Ser Leu Arg Lys Met Phe Gly Asn Gly Arg Ala Arg Ser Gly 

                325                 330                 335     





Val Ile Val Leu Pro Cys Gly Ala Gly Lys Ser Leu Val Gly Val Thr 

            340                 345                 350         





Ala Ala Cys Thr Val Arg Lys Arg Cys Leu Val Leu Gly Asn Ser Ala 

        355                 360                 365             





Val Ser Val Glu Gln Trp Lys Ala Gln Phe Lys Met Trp Ser Thr Ile 

    370                 375                 380                 





Asp Asp Ser Gln Ile Cys Arg Phe Thr Ser Asp Ala Lys Asp Lys Pro 

385                 390                 395                 400 





Ile Gly Cys Ser Val Ala Ile Ser Thr Tyr Ser Met Leu Gly His Thr 

                405                 410                 415     





Thr Lys Arg Ser Trp Glu Ala Glu Arg Val Met Glu Trp Leu Lys Thr 

            420                 425                 430         





Gln Glu Trp Gly Leu Met Ile Leu Asp Glu Val His Thr Ile Pro Ala 

        435                 440                 445             





Lys Met Phe Arg Arg Val Leu Thr Ile Val Gln Ala His Cys Lys Leu 

    450                 455                 460                 





Gly Leu Thr Ala Thr Leu Val Arg Glu Asp Asp Lys Ile Val Asp Leu 

465                 470                 475                 480 





Asn Phe Leu Ile Gly Pro Lys Leu Tyr Glu Ala Asn Trp Met Glu Leu 

                485                 490                 495     





Gln Asn Asn Gly Tyr Ile Ala Lys Val Gln Cys Ala Glu Val Trp Cys 

            500                 505                 510         





Pro Met Ser Pro Glu Phe Tyr Arg Glu Tyr Val Ala Ile Lys Thr Lys 

        515                 520                 525             





Lys Arg Ile Leu Leu Tyr Thr Met Asn Pro Asn Lys Phe Arg Ala Cys 

    530                 535                 540                 





Gln Phe Leu Ile Lys Phe His Glu Arg Arg Asn Asp Lys Ile Ile Val 

545                 550                 555                 560 





Phe Ala Asp Asn Val Phe Ala Leu Lys Glu Tyr Ala Ile Arg Leu Asn 

                565                 570                 575     





Lys Pro Tyr Ile Tyr Gly Pro Thr Ser Gln Gly Glu Arg Met Gln Ile 

            580                 585                 590         





Leu Gln Asn Phe Lys His Asn Pro Lys Ile Asn Thr Ile Phe Ile Ser 

        595                 600                 605             





Lys Val Gly Asp Thr Ser Phe Asp Leu Pro Glu Ala Asn Val Leu Ile 

    610                 615                 620                 





Gln Ile Ser Ser His Gly Gly Ser Arg Arg Gln Glu Ala Gln Arg Leu 

625                 630                 635                 640 





Gly Arg Val Leu Arg Ala Lys Lys Gly Met Val Ala Glu Glu Tyr Asn 

                645                 650                 655     





Ala Phe Phe Tyr Ser Leu Val Ser Gln Asp Thr Gln Glu Met Ala Tyr 

            660                 665                 670         





Ser Thr Lys Arg Gln Arg Phe Leu Val Asp Gln Gly Tyr Ser Phe Lys 

        675                 680                 685             





Val Ile Thr Lys Leu Ala Gly Met Glu Glu Glu Asp Leu Ala Phe Ser 

    690                 695                 700                 





Thr Lys Glu Glu Gln Gln Gln Leu Leu Gln Lys Val Leu Ala Ala Thr 

705                 710                 715                 720 





Asp Leu Asp Ala Glu Glu Glu Val Val Ala Gly Glu Phe Gly Ser Arg 

                725                 730                 735     





Ser Ser Gln Ala Ser Arg Arg Phe Gly Thr Met Ser Ser Met Ser Gly 

            740                 745                 750         





Ala Asp Asp Thr Val Tyr Met Glu Tyr His Ser Ser Arg Ser Lys Ala 

        755                 760                 765             





Pro Ser Lys His Val His Pro Leu Phe Lys Arg Phe Arg Lys 

    770                 775                 780         





<210>  76

<211>  3713

<212>  DNA

<213>  Homo sapiens



<400>  76

aagtgatgtc acaggcccca tgtgagcgga ttgcaacaca tgcagctgcc tggagagagg       60



gagccggtgt cctacgtcag agccgccgcc gccgcggagc cgccgccggg gaggagcagc      120



cgctgccgcc caggactggg cccttaggga ggaggaggcg agaagatggc ggacgacccc      180



agtgctgccg acaggaacgt ggagatctgg aagatcaaga agctcattaa gagcttggag      240



gcggcccgcg gcaatggcac cagcatgata tcattgatca ttcctcccaa agaccagatt      300



tcacgagtgg caaaaatgtt agcggatgag tttggaactg catctaacat taagtcacga      360



gtaaaccgcc tttcagtcct gggagccatt acatctgtac aacaaagact caaactttat      420



aacaaagtac ctccaaatgg tctggttgta tactgtggaa caattgtaac agaagaagga      480



aaggaaaaga aagtcaacat tgactttgaa cctttcaaac caattaatac gtcattgtat      540



ttgtgtgaca acaaattcca tacagaggct cttacagcac tactttcaga tgatagcaag      600



tttggattca ttgtaataga tggtagtggt gcactttttg gcacactcca aggaaacaca      660



agagaagtcc tgcacaaatt cactgtggat ctcccaaaga aacacggtag aggaggtcag      720



tcagccttgc gttttgcccg tttaagaatg gaaaagcgac ataactatgt tcggaaagta      780



gcagagactg ctgtgcagct gtttatttct ggggacaaag tgaatgtggc tggtctagtt      840



ttagctggat ccgctgactt taaaactgaa ctaagtcaat ctgatatgtt tgatcagagg      900



ttacaatcaa aagttttaaa attagttgat atatcctatg gtggtgaaaa tggattcaac      960



caagctattg agttatctac tgaagtcctc tccaacgtga aattcattca agagaagaaa     1020



ttaataggac gatactttga tgaaatcagc caggacacgg gcaagtactg ttttggcgtt     1080



gaagatacac taaaggcttt ggaaatggga gctgtagaaa ttctaatagt ctatgaaaat     1140



ctggatataa tgagatatgt tcttcattgc caaggcacag aagaggagaa aattctctat     1200



ctaactccag agcaagaaaa ggataaatct catttcacag acaaagagac cggacaggaa     1260



catgagctta tcgagagcat gcccctgttg gaatggtttg ctaacaacta taaaaaattt     1320



ggagctacgt tggaaattgt cacagataaa tcacaagaag ggtctcagtt tgtgaaagga     1380



tttggtggaa ttggaggtat cttgcggtac cgagtagatt tccagggaat ggaataccaa     1440



ggaggagacg atgaattttt tgaccttgat gactactagg tagtcgacat gggtccggca     1500



aaacgtgcct caccctccag catccaaccc aaggagcata cccatggtgg aatccaaaca     1560



gatccctgcc ttacaattgg aacatttcca gaacttaatc catgagcatt ggatattgaa     1620



aagaaaaccg aaacaaaacc agacccagcc ctacactttg gtttgtcatg gtgtcagcgc     1680



agcagcctac aactaagttc ctaaacgcca ctttggacta atttaaaaaa gaatcccagt     1740



ttttactttt actggatggt gaaattggtt gctcttgtat tttatgaaaa aaaatgattt     1800



ttttaacctt catacataga agcaaaaata ctttaactgc tgtaaacctt caaaagttaa     1860



tagaagtgag atcatactgg tttgtttctt attttgattg gagaaaaatt aaattgctgc     1920



atttcgcagt gacccattta catggcattc tcagcttaga ctgcgtaaga agaaatatat     1980



gtggtgaaat gttggaacca tttctctctt ggtctctgtt taatgttgaa agggtgagct     2040



aataggaggc actttcaact tcactccctc acgctacccc gtccccctcc agactggcag     2100



tttcaaggat gcaaattgca ttgcaaaatc aaactgactc atgaagcatt tgggccagtg     2160



cactgtttac ttccatctgt ttgcagacac atttgtgccc ggcgtttggg agccctttgt     2220



atcaatgttc tgacaagggt ccctataacc ttaacctact cgaaaccggt ttgggatgga     2280



tatgatgggg cttctgtgct attgctggga ttgggagaaa taaaacatgc aatttaagtg     2340



gaagcgaaga aatttaaaga ggattttatt ttgcttgggt caatccttgt taaaagggag     2400



gtggatgtgt tttccttgtg ttggatggca tgagattatg tgaatgtttt gatttattaa     2460



aatgaactgc aaggtttttc acaggaacga cagacatgta tgactgcatg taattataaa     2520



ctcctgacct cctggtgggg ttggagcatc tgtttcaaat gtgggactta caagcacttc     2580



tcacatgaga aattaggggc gggtgggaag ggatgggaca cagcttctgg caccatggat     2640



ttaagaccat gttggatcca aaagttggcc tgaaaccctg aagcttatgc ttcacagctg     2700



ggctgtaagt cagacttgaa cccagctgat atgcaaggtc atggcgtgcc cagggtggtg     2760



acagttgaac aaagtgtata gtacgtgccc agtggtagcg atggaaaaaa gtataccaaa     2820



tggactttga aggaccaaag gttttaaaag tcaattggta tcacctccac actgactagg     2880



gtagtggggt gcatttggtt ttcaaattgg gtacttttaa cactttagtg cctgactgct     2940



gttctttact gacttgattc agtcactcgt agctttattg gtctgaacca gctccttgtt     3000



cccaggttac agacctgcct atcgttccaa taatcctgtt tcacttgaat gaagggagta     3060



tgtcttaaat gtaaagtttc tggttctcac actgtactct gaggtccaaa tactgtctgt     3120



caatgtgtaa cctgatgtct caaccccctg tgagaagagt ccattatttg gtgttcacca     3180



acgtgggaga cttcaccgga acaggctttt ttgctttggg ctctgctatt tgtttgcaga     3240



acacccaaga gcgagcaaac atgctctctt cacagcagta ccttagggtt ttgccattgt     3300



aaatgggtct gatgtgatat gacaagacca gagaaattgg atgtaaattt acatttttga     3360



atatgcttgt tgtttcacat gatacattta gggtatgcag ctccttttgt agtttttatt     3420



tttactattt aagtttggaa atgatgccaa atttttgtat ttctttaatc aatgtgttct     3480



cttcggtgat atatattgca ttatatattg atgtgtgtat caatatatat tgatatgtat     3540



tacacttaca catacaaaca catataagag ggggtgaaaa ccgtagcctt tgcattctct     3600



atagcctctg cagagagata ctaagcagca aaatcttggt gttgtgatgt acagaaatgg     3660



agaagagtat taaaccatat ttaagaataa aaaaaaaaaa aaaaaaaaaa aaa            3713





<210>  77

<211>  437

<212>  PRT

<213>  Homo sapiens



<400>  77



Met Ala Asp Asp Pro Ser Ala Ala Asp Arg Asn Val Glu Ile Trp Lys 

1               5                   10                  15      





Ile Lys Lys Leu Ile Lys Ser Leu Glu Ala Ala Arg Gly Asn Gly Thr 

            20                  25                  30          





Ser Met Ile Ser Leu Ile Ile Pro Pro Lys Asp Gln Ile Ser Arg Val 

        35                  40                  45              





Ala Lys Met Leu Ala Asp Glu Phe Gly Thr Ala Ser Asn Ile Lys Ser 

    50                  55                  60                  





Arg Val Asn Arg Leu Ser Val Leu Gly Ala Ile Thr Ser Val Gln Gln 

65                  70                  75                  80  





Arg Leu Lys Leu Tyr Asn Lys Val Pro Pro Asn Gly Leu Val Val Tyr 

                85                  90                  95      





Cys Gly Thr Ile Val Thr Glu Glu Gly Lys Glu Lys Lys Val Asn Ile 

            100                 105                 110         





Asp Phe Glu Pro Phe Lys Pro Ile Asn Thr Ser Leu Tyr Leu Cys Asp 

        115                 120                 125             





Asn Lys Phe His Thr Glu Ala Leu Thr Ala Leu Leu Ser Asp Asp Ser 

    130                 135                 140                 





Lys Phe Gly Phe Ile Val Ile Asp Gly Ser Gly Ala Leu Phe Gly Thr 

145                 150                 155                 160 





Leu Gln Gly Asn Thr Arg Glu Val Leu His Lys Phe Thr Val Asp Leu 

                165                 170                 175     





Pro Lys Lys His Gly Arg Gly Gly Gln Ser Ala Leu Arg Phe Ala Arg 

            180                 185                 190         





Leu Arg Met Glu Lys Arg His Asn Tyr Val Arg Lys Val Ala Glu Thr 

        195                 200                 205             





Ala Val Gln Leu Phe Ile Ser Gly Asp Lys Val Asn Val Ala Gly Leu 

    210                 215                 220                 





Val Leu Ala Gly Ser Ala Asp Phe Lys Thr Glu Leu Ser Gln Ser Asp 

225                 230                 235                 240 





Met Phe Asp Gln Arg Leu Gln Ser Lys Val Leu Lys Leu Val Asp Ile 

                245                 250                 255     





Ser Tyr Gly Gly Glu Asn Gly Phe Asn Gln Ala Ile Glu Leu Ser Thr 

            260                 265                 270         





Glu Val Leu Ser Asn Val Lys Phe Ile Gln Glu Lys Lys Leu Ile Gly 

        275                 280                 285             





Arg Tyr Phe Asp Glu Ile Ser Gln Asp Thr Gly Lys Tyr Cys Phe Gly 

    290                 295                 300                 





Val Glu Asp Thr Leu Lys Ala Leu Glu Met Gly Ala Val Glu Ile Leu 

305                 310                 315                 320 





Ile Val Tyr Glu Asn Leu Asp Ile Met Arg Tyr Val Leu His Cys Gln 

                325                 330                 335     





Gly Thr Glu Glu Glu Lys Ile Leu Tyr Leu Thr Pro Glu Gln Glu Lys 

            340                 345                 350         





Asp Lys Ser His Phe Thr Asp Lys Glu Thr Gly Gln Glu His Glu Leu 

        355                 360                 365             





Ile Glu Ser Met Pro Leu Leu Glu Trp Phe Ala Asn Asn Tyr Lys Lys 

    370                 375                 380                 





Phe Gly Ala Thr Leu Glu Ile Val Thr Asp Lys Ser Gln Glu Gly Ser 

385                 390                 395                 400 





Gln Phe Val Lys Gly Phe Gly Gly Ile Gly Gly Ile Leu Arg Tyr Arg 

                405                 410                 415     





Val Asp Phe Gln Gly Met Glu Tyr Gln Gly Gly Asp Asp Glu Phe Phe 

            420                 425                 430         





Asp Leu Asp Asp Tyr 

        435         





<210>  78

<211>  1006

<212>  DNA

<213>  Homo sapiens



<400>  78

cagccgcacg tgggctcggc gcgatggagg aggagacgca tactgacgcc aaaatccgtg       60



ctgaaaatgg aacagggtcc agccctcggg gtcctggctg cagcctccgg cactttgcct      120



gcgaacagaa cctgctgtcg cggccagatg gctctgcttc cttcctgcaa ggtgacacct      180



ctgtcctggc gggtgtgtac gggccggccg aggtgaaggt cagcaaagag attttcaaca      240



aggccacact cgaagtgatc ctgaggccga agattgggct gcctggtgtt gcagagaaga      300



gccgggagcg gctgatcagg aacacgtgcg aggcggtggt gctgggcacg ttgcaccccc      360



gcacctccat caccgtggtg ctgcaggttg tcagcgatgc cggctctctc ctggcctgtt      420



gtctgaatgc cgcctgcatg gcattggtgg atgcaggtgt gcccatgcgg gctctcttct      480



gtggggtcgc ctgcgccctg gactctgatg ggaccctcgt gctggatcct acatccaagc      540



aagaaaagga ggcccgggca gtcctgacct ttgccctgga cagcgtggaa cggaagctgc      600



tgatgtccag caccaagggg ctctactcag acactgagct ccagcagtgc ctggctgcgg      660



cccaggccgc ttcgcaacac gtcttccgtt tctaccggga atcgctgcag aggcgttact      720



ccaagagctg aggcaagctg gggcaagggg ccgctcccat tgcctccacc cactcacccc      780



ctacagcctg aagcaaacca gcagcccagc cttgcctctc tgacccatgg gctccttgag      840



cctgcagctc tgtaaccaca gggctcctgt ggggaggcct tggcctgtga cagcccccag      900



gcctgggggc acagatcccc ccagcaagga taacattcaa aggagctcac atttatggaa      960



tggatgaatc aataaattaa ttcactttaa caaaaaaaaa aaaaaa                    1006





<210>  79

<211>  235

<212>  PRT

<213>  Homo sapiens



<400>  79



Met Glu Glu Glu Thr His Thr Asp Ala Lys Ile Arg Ala Glu Asn Gly 

1               5                   10                  15      





Thr Gly Ser Ser Pro Arg Gly Pro Gly Cys Ser Leu Arg His Phe Ala 

            20                  25                  30          





Cys Glu Gln Asn Leu Leu Ser Arg Pro Asp Gly Ser Ala Ser Phe Leu 

        35                  40                  45              





Gln Gly Asp Thr Ser Val Leu Ala Gly Val Tyr Gly Pro Ala Glu Val 

    50                  55                  60                  





Lys Val Ser Lys Glu Ile Phe Asn Lys Ala Thr Leu Glu Val Ile Leu 

65                  70                  75                  80  





Arg Pro Lys Ile Gly Leu Pro Gly Val Ala Glu Lys Ser Arg Glu Arg 

                85                  90                  95      





Leu Ile Arg Asn Thr Cys Glu Ala Val Val Leu Gly Thr Leu His Pro 

            100                 105                 110         





Arg Thr Ser Ile Thr Val Val Leu Gln Val Val Ser Asp Ala Gly Ser 

        115                 120                 125             





Leu Leu Ala Cys Cys Leu Asn Ala Ala Cys Met Ala Leu Val Asp Ala 

    130                 135                 140                 





Gly Val Pro Met Arg Ala Leu Phe Cys Gly Val Ala Cys Ala Leu Asp 

145                 150                 155                 160 





Ser Asp Gly Thr Leu Val Leu Asp Pro Thr Ser Lys Gln Glu Lys Glu 

                165                 170                 175     





Ala Arg Ala Val Leu Thr Phe Ala Leu Asp Ser Val Glu Arg Lys Leu 

            180                 185                 190         





Leu Met Ser Ser Thr Lys Gly Leu Tyr Ser Asp Thr Glu Leu Gln Gln 

        195                 200                 205             





Cys Leu Ala Ala Ala Gln Ala Ala Ser Gln His Val Phe Arg Phe Tyr 

    210                 215                 220                 





Arg Glu Ser Leu Gln Arg Arg Tyr Ser Lys Ser 

225                 230                 235 





<210>  80

<211>  3727

<212>  DNA

<213>  Homo sapiens



<400>  80

ctgctttcaa ggtgtctaga tacagagtga agaatgtcac agtaggaagt gcactggact       60



aggggagtca ggagacccgg gttcttgtgt tggcaccatc actcatgagc tacgaggtga      120



cttcaggctg ccattggacc tgtcaagtgc ctgagtcatg tgataatggg ctacattgcg      180



cagggcccct gggccatctc cacaggagat gccagaggac gagtgcccac ttgctggtct      240



tcacagagca cgctgaaatg agacggttta agcggaagca tcttactgcc attgactgcc      300



agcatttggc tcggagtcac ttggctgtga cccagccctt cggtcaaaga tggacaaaca      360



gagatccgaa ccatggtctc tatcctaaac cgagaacaaa aagagggagt aggggtcagg      420



gaagtcaaag atgcatccct gagttcttcc tagcaggcaa gcagccgtgc accaatgaca      480



tggccaaaag caattctgtt ggccaggaca gctgtcagga ctctgagggt gacatgatct      540



ttcctgcaga gagcagctgt gcactgcctc aggaaggcag tgcagggccg ggctcaccag      600



ggtctgcccc gccctccagg aagcggtctt ggtcctctga ggaagagagt aaccaggcta      660



ccgggaccag ccggtgggat ggagtttcta agaaagctcc acggcaccat ttgtctgtgc      720



catgcacaag gcctagggag gccaggcaag aagcagagga cagtacgtct cggctctctg      780



cggagtctgg tgaaaccgac caagatgctg gggacgtggg tcctgatccc attcctgact      840



catactatgg gcttcttggg accttgccct gccaggaagc actgagccac atttgcagcc      900



tgcctagtga ggtcctgagg cacgtgtttg ccttcctccc ggtggaagac ctctattgga      960



acctgagctt ggtgtgccac ttgtggaggg agatcatcag tgacccgctg ttcattcctt     1020



ggaagaagct gtaccatcga tacctgatga atgaagagca agctgtcagc aaagtggacg     1080



gcatcctgtc taactgtggc atagaaaagg agtcagacct gtgtgtgctg aacctcatac     1140



gatacacagc caccactaag tgctctccga gtgtggatcc cgagagggtg ctgtggagtc     1200



tgagggacca ccccctcctc cccgaggctg aggcgtgtgt gcggcaacac ctccccgacc     1260



tctacgctgc tgccgggggt gtcaacatct gggccctggt ggcggctgtg gtgctcctct     1320



ccagcagtgt gaatgacatc cagcgactgc tcttctgcct ccggagaccc agctccacgg     1380



tgaccatgcc agatgtcacc gagaccctgt actgcatagc cgtgcttctc tacgccatga     1440



gggagaaggg gattaacatc agcaatagga ttcactacaa cattttctat tgcctatatc     1500



ttcaggagaa ttcctgcact caggccacaa aagttaaaga ggagccatct gtctggccag     1560



gcaagaaaac catccaactt acacatgaac aacagctgat tctgaatcac aagatggaac     1620



ctctccaggt ggtgaaaatt atggcctttg ccggcactgg gaagacctca acgctggtca     1680



agtatgcaga gaagtggtct cagagcaggt ttctgtatgt gacattcaac aagagcatcg     1740



caaagcaggc cgaacgcgtc ttccccagca acgtcatctg caaaaccttc cactccatgg     1800



cctacgggca catagggcgg aagtaccagt caaagaagaa gttgaatctc ttcaagttaa     1860



cacccttcat ggtcaactcc gtccttgctg aagggaaggg tggattcata agagccaagc     1920



ttgtgtgtaa gactctagaa aacttctttg cctcggctga cgaagagctg accattgatc     1980



acgtgcctat ttggtgtaag aacagccaag gacagagagt catggttgag cagagtgaaa     2040



aactgaatgg tgtccttgaa gcgagccgcc tctgggataa catgcggaag ctgggggagt     2100



gcacagaaga ggcgcaccag atgactcatg acggctactt gaaactctgg cagctgagca     2160



agccttcgct ggcctctttt gacgccatct ttgtggatga ggcccaggac tgcacaccag     2220



ctatcatgaa catagttctg tctcagccat gtgggaaaat ctttgtaggg gacccgcacc     2280



agcagatcta taccttccgg ggtgcggtca acgccctgtt cacagtgccc cacacccacg     2340



tcttctatct cacgcagagt tttcggtttg gtgtggaaat agcttatgtg ggagctacta     2400



tcttggatgt ttgcaagaga gtcaggaaaa agactttggt tggaggaaac catcagagtg     2460



gcattagagg tgacgcaaag gggcaagtgg ccttgttgtc ccggaccaac gccaacgtgt     2520



ttgatgaggc cgtacgggtg acggaagggg aattcccttc aaggatacat ttgattgggg     2580



ggattaaatc atttggattg gacagaatca ttgatatttg gatccttctt cagccagagg     2640



aagaacggag gaaacaaaac ctcgtcatta aagacaaatt tatcagaaga tgggtgcaca     2700



aagaaggctt tagtggcttc aagaggtatg tgaccgctgc cgaggacaag gagcttgaag     2760



ccaagatcgc agttgttgaa aagtataaca tcaggattcc agagctggtg caaaggatag     2820



aaaaatgcca tatagaagat ttggactttg cagagtacat tctgggcact gtgcacaaag     2880



ccaaaggcct ggagtttgac actgtgcatg ttttggatga ttttgtgaaa gtgccttgtg     2940



cccggcataa cctgccccag cttccgcact tcagagttga gtcattttct gaggatgaat     3000



ggaatttact gtatgttgca gtaactcgag ccaagaagcg tctcatcatg accaaatcat     3060



tggaaaacat tttgactttg gctggggagt acttcttgca agcagagctg acaagcaacg     3120



tcttaaaaac aggcgtggtg cgctgctgcg tgggacagtg caacaatgcc atccctgttg     3180



acaccgtcct taccatgaag aagctgccca tcacctatag caacaggaag gaaaacaagg     3240



ggggctacct ctgccactcc tgtgcggagc agcgcatcgg gcccctggcg ttcctgacag     3300



cctccccgga gcaggtgcgc gccatggagc gcactgtgga gaacatcgta ctgccccggc     3360



atgaggccct gctcttcctc gtcttctgag gacaaggcgc acgttctccg cagtgcagag     3420



cagcttgccg aggaccccgc gtgaagaaag ccagcgaggg gggcttctgc tccctgagac     3480



tctgggttca cccacagcac tttctgagga agaggacacc agcccaagct ggacctgcca     3540



tttctccact ccctacagac agccagtctc cacttgcctc ccctctggat gtatctggtc     3600



agggaagtgg gggatgttct tttgataaaa aaaaaaaaaa aaatttatgt atttaaactt     3660



ttattacaag atttcaatta aacaggcacc atagcactgg caaaaaaaaa aaaaaaaaaa     3720



aaaaaaa                                                               3727





<210>  81

<211>  1094

<212>  PRT

<213>  Homo sapiens



<400>  81



Met Ser Tyr Glu Val Thr Ser Gly Cys His Trp Thr Cys Gln Val Pro 

1               5                   10                  15      





Glu Ser Cys Asp Asn Gly Leu His Cys Ala Gly Pro Leu Gly His Leu 

            20                  25                  30          





His Arg Arg Cys Gln Arg Thr Ser Ala His Leu Leu Val Phe Thr Glu 

        35                  40                  45              





His Ala Glu Met Arg Arg Phe Lys Arg Lys His Leu Thr Ala Ile Asp 

    50                  55                  60                  





Cys Gln His Leu Ala Arg Ser His Leu Ala Val Thr Gln Pro Phe Gly 

65                  70                  75                  80  





Gln Arg Trp Thr Asn Arg Asp Pro Asn His Gly Leu Tyr Pro Lys Pro 

                85                  90                  95      





Arg Thr Lys Arg Gly Ser Arg Gly Gln Gly Ser Gln Arg Cys Ile Pro 

            100                 105                 110         





Glu Phe Phe Leu Ala Gly Lys Gln Pro Cys Thr Asn Asp Met Ala Lys 

        115                 120                 125             





Ser Asn Ser Val Gly Gln Asp Ser Cys Gln Asp Ser Glu Gly Asp Met 

    130                 135                 140                 





Ile Phe Pro Ala Glu Ser Ser Cys Ala Leu Pro Gln Glu Gly Ser Ala 

145                 150                 155                 160 





Gly Pro Gly Ser Pro Gly Ser Ala Pro Pro Ser Arg Lys Arg Ser Trp 

                165                 170                 175     





Ser Ser Glu Glu Glu Ser Asn Gln Ala Thr Gly Thr Ser Arg Trp Asp 

            180                 185                 190         





Gly Val Ser Lys Lys Ala Pro Arg His His Leu Ser Val Pro Cys Thr 

        195                 200                 205             





Arg Pro Arg Glu Ala Arg Gln Glu Ala Glu Asp Ser Thr Ser Arg Leu 

    210                 215                 220                 





Ser Ala Glu Ser Gly Glu Thr Asp Gln Asp Ala Gly Asp Val Gly Pro 

225                 230                 235                 240 





Asp Pro Ile Pro Asp Ser Tyr Tyr Gly Leu Leu Gly Thr Leu Pro Cys 

                245                 250                 255     





Gln Glu Ala Leu Ser His Ile Cys Ser Leu Pro Ser Glu Val Leu Arg 

            260                 265                 270         





His Val Phe Ala Phe Leu Pro Val Glu Asp Leu Tyr Trp Asn Leu Ser 

        275                 280                 285             





Leu Val Cys His Leu Trp Arg Glu Ile Ile Ser Asp Pro Leu Phe Ile 

    290                 295                 300                 





Pro Trp Lys Lys Leu Tyr His Arg Tyr Leu Met Asn Glu Glu Gln Ala 

305                 310                 315                 320 





Val Ser Lys Val Asp Gly Ile Leu Ser Asn Cys Gly Ile Glu Lys Glu 

                325                 330                 335     





Ser Asp Leu Cys Val Leu Asn Leu Ile Arg Tyr Thr Ala Thr Thr Lys 

            340                 345                 350         





Cys Ser Pro Ser Val Asp Pro Glu Arg Val Leu Trp Ser Leu Arg Asp 

        355                 360                 365             





His Pro Leu Leu Pro Glu Ala Glu Ala Cys Val Arg Gln His Leu Pro 

    370                 375                 380                 





Asp Leu Tyr Ala Ala Ala Gly Gly Val Asn Ile Trp Ala Leu Val Ala 

385                 390                 395                 400 





Ala Val Val Leu Leu Ser Ser Ser Val Asn Asp Ile Gln Arg Leu Leu 

                405                 410                 415     





Phe Cys Leu Arg Arg Pro Ser Ser Thr Val Thr Met Pro Asp Val Thr 

            420                 425                 430         





Glu Thr Leu Tyr Cys Ile Ala Val Leu Leu Tyr Ala Met Arg Glu Lys 

        435                 440                 445             





Gly Ile Asn Ile Ser Asn Arg Ile His Tyr Asn Ile Phe Tyr Cys Leu 

    450                 455                 460                 





Tyr Leu Gln Glu Asn Ser Cys Thr Gln Ala Thr Lys Val Lys Glu Glu 

465                 470                 475                 480 





Pro Ser Val Trp Pro Gly Lys Lys Thr Ile Gln Leu Thr His Glu Gln 

                485                 490                 495     





Gln Leu Ile Leu Asn His Lys Met Glu Pro Leu Gln Val Val Lys Ile 

            500                 505                 510         





Met Ala Phe Ala Gly Thr Gly Lys Thr Ser Thr Leu Val Lys Tyr Ala 

        515                 520                 525             





Glu Lys Trp Ser Gln Ser Arg Phe Leu Tyr Val Thr Phe Asn Lys Ser 

    530                 535                 540                 





Ile Ala Lys Gln Ala Glu Arg Val Phe Pro Ser Asn Val Ile Cys Lys 

545                 550                 555                 560 





Thr Phe His Ser Met Ala Tyr Gly His Ile Gly Arg Lys Tyr Gln Ser 

                565                 570                 575     





Lys Lys Lys Leu Asn Leu Phe Lys Leu Thr Pro Phe Met Val Asn Ser 

            580                 585                 590         





Val Leu Ala Glu Gly Lys Gly Gly Phe Ile Arg Ala Lys Leu Val Cys 

        595                 600                 605             





Lys Thr Leu Glu Asn Phe Phe Ala Ser Ala Asp Glu Glu Leu Thr Ile 

    610                 615                 620                 





Asp His Val Pro Ile Trp Cys Lys Asn Ser Gln Gly Gln Arg Val Met 

625                 630                 635                 640 





Val Glu Gln Ser Glu Lys Leu Asn Gly Val Leu Glu Ala Ser Arg Leu 

                645                 650                 655     





Trp Asp Asn Met Arg Lys Leu Gly Glu Cys Thr Glu Glu Ala His Gln 

            660                 665                 670         





Met Thr His Asp Gly Tyr Leu Lys Leu Trp Gln Leu Ser Lys Pro Ser 

        675                 680                 685             





Leu Ala Ser Phe Asp Ala Ile Phe Val Asp Glu Ala Gln Asp Cys Thr 

    690                 695                 700                 





Pro Ala Ile Met Asn Ile Val Leu Ser Gln Pro Cys Gly Lys Ile Phe 

705                 710                 715                 720 





Val Gly Asp Pro His Gln Gln Ile Tyr Thr Phe Arg Gly Ala Val Asn 

                725                 730                 735     





Ala Leu Phe Thr Val Pro His Thr His Val Phe Tyr Leu Thr Gln Ser 

            740                 745                 750         





Phe Arg Phe Gly Val Glu Ile Ala Tyr Val Gly Ala Thr Ile Leu Asp 

        755                 760                 765             





Val Cys Lys Arg Val Arg Lys Lys Thr Leu Val Gly Gly Asn His Gln 

    770                 775                 780                 





Ser Gly Ile Arg Gly Asp Ala Lys Gly Gln Val Ala Leu Leu Ser Arg 

785                 790                 795                 800 





Thr Asn Ala Asn Val Phe Asp Glu Ala Val Arg Val Thr Glu Gly Glu 

                805                 810                 815     





Phe Pro Ser Arg Ile His Leu Ile Gly Gly Ile Lys Ser Phe Gly Leu 

            820                 825                 830         





Asp Arg Ile Ile Asp Ile Trp Ile Leu Leu Gln Pro Glu Glu Glu Arg 

        835                 840                 845             





Arg Lys Gln Asn Leu Val Ile Lys Asp Lys Phe Ile Arg Arg Trp Val 

    850                 855                 860                 





His Lys Glu Gly Phe Ser Gly Phe Lys Arg Tyr Val Thr Ala Ala Glu 

865                 870                 875                 880 





Asp Lys Glu Leu Glu Ala Lys Ile Ala Val Val Glu Lys Tyr Asn Ile 

                885                 890                 895     





Arg Ile Pro Glu Leu Val Gln Arg Ile Glu Lys Cys His Ile Glu Asp 

            900                 905                 910         





Leu Asp Phe Ala Glu Tyr Ile Leu Gly Thr Val His Lys Ala Lys Gly 

        915                 920                 925             





Leu Glu Phe Asp Thr Val His Val Leu Asp Asp Phe Val Lys Val Pro 

    930                 935                 940                 





Cys Ala Arg His Asn Leu Pro Gln Leu Pro His Phe Arg Val Glu Ser 

945                 950                 955                 960 





Phe Ser Glu Asp Glu Trp Asn Leu Leu Tyr Val Ala Val Thr Arg Ala 

                965                 970                 975     





Lys Lys Arg Leu Ile Met Thr Lys Ser Leu Glu Asn Ile Leu Thr Leu 

            980                 985                 990         





Ala Gly Glu Tyr Phe Leu Gln Ala  Glu Leu Thr Ser Asn  Val Leu Lys 

        995                 1000                 1005             





Thr Gly  Val Val Arg Cys Cys  Val Gly Gln Cys Asn  Asn Ala Ile 

    1010                 1015                 1020             





Pro Val  Asp Thr Val Leu Thr  Met Lys Lys Leu Pro  Ile Thr Tyr 

    1025                 1030                 1035             





Ser Asn  Arg Lys Glu Asn Lys  Gly Gly Tyr Leu Cys  His Ser Cys 

    1040                 1045                 1050             





Ala Glu  Gln Arg Ile Gly Pro  Leu Ala Phe Leu Thr  Ala Ser Pro 

    1055                 1060                 1065             





Glu Gln  Val Arg Ala Met Glu  Arg Thr Val Glu Asn  Ile Val Leu 

    1070                 1075                 1080             





Pro Arg  His Glu Ala Leu Leu  Phe Leu Val Phe 

    1085                 1090                 





<210>  82

<211>  3540

<212>  DNA

<213>  Homo sapiens



<400>  82

cagaggagga gctcgctgcc gggggacgct gggctgagcg gccggcggcg cgggcccggc       60



ggcggcggca gcggggtccg ggtccggagc gccacatgag acggtttaag cggaagcatc      120



ttactgccat tgactgccag catttggctc ggagtcactt ggctgtgacc cagcccttcg      180



gtcaaagatg gacaaacaga gatccgaacc atggtctcta tcctaaaccg agaacaaaaa      240



gagggagtag gggtcaggga agtcaaagat gcatccctga gttcttccta gcaggcaagc      300



agccgtgcac caatgacatg gccaaaagca attctgttgg ccaggacagc tgtcaggact      360



ctgagggtga catgatcttt cctgcagaga gcagctgtgc actgcctcag gaaggcagtg      420



cagggccggg ctcaccaggg tctgccccgc cctccaggaa gcggtcttgg tcctctgagg      480



aagagagtaa ccaggctacc gggaccagcc ggtgggatgg agtttctaag aaagctccac      540



ggcaccattt gtctgtgcca tgcacaaggc ctagggaggc caggcaagaa gcagaggaca      600



gtacgtctcg gctctctgcg gagtctggtg aaaccgacca agatgctggg gacgtgggtc      660



ctgatcccat tcctgactca tactatgggc ttcttgggac cttgccctgc caggaagcac      720



tgagccacat ttgcagcctg cctagtgagg tcctgaggca cgtgtttgcc ttcctcccgg      780



tggaagacct ctattggaac ctgagcttgg tgtgccactt gtggagggag atcatcagtg      840



acccgctgtt cattccttgg aagaagctgt accatcgata cctgatgaat gaagagcaag      900



ctgtcagcaa agtggacggc atcctgtcta actgtggcat agaaaaggag tcagacctgt      960



gtgtgctgaa cctcatacga tacacagcca ccactaagtg ctctccgagt gtggatcccg     1020



agagggtgct gtggagtctg agggaccacc ccctcctccc cgaggctgag gcgtgtgtgc     1080



ggcaacacct ccccgacctc tacgctgctg ccgggggtgt caacatctgg gccctggtgg     1140



cggctgtggt gctcctctcc agcagtgtga atgacatcca gcgactgctc ttctgcctcc     1200



ggagacccag ctccacggtg accatgccag atgtcaccga gaccctgtac tgcatagccg     1260



tgcttctcta cgccatgagg gagaagggga ttaacatcag caataggatt cactacaaca     1320



ttttctattg cctatatctt caggagaatt cctgcactca ggccacaaaa gttaaagagg     1380



agccatctgt ctggccaggc aagaaaacca tccaacttac acatgaacaa cagctgattc     1440



tgaatcacaa gatggaacct ctccaggtgg tgaaaattat ggcctttgcc ggcactggga     1500



agacctcaac gctggtcaag tatgcagaga agtggtctca gagcaggttt ctgtatgtga     1560



cattcaacaa gagcatcgca aagcaggccg aacgcgtctt ccccagcaac gtcatctgca     1620



aaaccttcca ctccatggcc tacgggcaca tagggcggaa gtaccagtca aagaagaagt     1680



tgaatctctt caagttaaca cccttcatgg tcaactccgt ccttgctgaa gggaagggtg     1740



gattcataag agccaagctt gtgtgtaaga ctctagaaaa cttctttgcc tcggctgacg     1800



aagagctgac cattgatcac gtgcctattt ggtgtaagaa cagccaagga cagagagtca     1860



tggttgagca gagtgaaaaa ctgaatggtg tccttgaagc gagccgcctc tgggataaca     1920



tgcggaagct gggggagtgc acagaagagg cgcaccagat gactcatgac ggctacttga     1980



aactctggca gctgagcaag ccttcgctgg cctcttttga cgccatcttt gtggatgagg     2040



cccaggactg cacaccagct atcatgaaca tagttctgtc tcagccatgt gggaaaatct     2100



ttgtagggga cccgcaccag cagatctata ccttccgggg tgcggtcaac gccctgttca     2160



cagtgcccca cacccacgtc ttctatctca cgcagagttt tcggtttggt gtggaaatag     2220



cttatgtggg agctactatc ttggatgttt gcaagagagt caggaaaaag actttggttg     2280



gaggaaacca tcagagtggc attagaggtg acgcaaaggg gcaagtggcc ttgttgtccc     2340



ggaccaacgc caacgtgttt gatgaggccg tacgggtgac ggaaggggaa ttcccttcaa     2400



ggatacattt gattgggggg attaaatcat ttggattgga cagaatcatt gatatttgga     2460



tccttcttca gccagaggaa gaacggagga aacaaaacct cgtcattaaa gacaaattta     2520



tcagaagatg ggtgcacaaa gaaggcttta gtggcttcaa gaggtatgtg accgctgccg     2580



aggacaagga gcttgaagcc aagatcgcag ttgttgaaaa gtataacatc aggattccag     2640



agctggtgca aaggatagaa aaatgccata tagaagattt ggactttgca gagtacattc     2700



tgggcactgt gcacaaagcc aaaggcctgg agtttgacac tgtgcatgtt ttggatgatt     2760



ttgtgaaagt gccttgtgcc cggcataacc tgccccagct tccgcacttc agagttgagt     2820



cattttctga ggatgaatgg aatttactgt atgttgcagt aactcgagcc aagaagcgtc     2880



tcatcatgac caaatcattg gaaaacattt tgactttggc tggggagtac ttcttgcaag     2940



cagagctgac aagcaacgtc ttaaaaacag gcgtggtgcg ctgctgcgtg ggacagtgca     3000



acaatgccat ccctgttgac accgtcctta ccatgaagaa gctgcccatc acctatagca     3060



acaggaagga aaacaagggg ggctacctct gccactcctg tgcggagcag cgcatcgggc     3120



ccctggcgtt cctgacagcc tccccggagc aggtgcgcgc catggagcgc actgtggaga     3180



acatcgtact gccccggcat gaggccctgc tcttcctcgt cttctgagga caaggcgcac     3240



gttctccgca gtgcagagca gcttgccgag gaccccgcgt gaagaaagcc agcgaggggg     3300



gcttctgctc cctgagactc tgggttcacc cacagcactt tctgaggaag aggacaccag     3360



cccaagctgg acctgccatt tctccactcc ctacagacag ccagtctcca cttgcctccc     3420



ctctggatgt atctggtcag ggaagtgggg gatgttcttt tgataaaaaa aaaaaaaaaa     3480



atttatgtat ttaaactttt attacaagat ttcaattaaa caggcaccat agcactggca     3540





<210>  83

<211>  1043

<212>  PRT

<213>  Homo sapiens



<400>  83



Met Arg Arg Phe Lys Arg Lys His Leu Thr Ala Ile Asp Cys Gln His 

1               5                   10                  15      





Leu Ala Arg Ser His Leu Ala Val Thr Gln Pro Phe Gly Gln Arg Trp 

            20                  25                  30          





Thr Asn Arg Asp Pro Asn His Gly Leu Tyr Pro Lys Pro Arg Thr Lys 

        35                  40                  45              





Arg Gly Ser Arg Gly Gln Gly Ser Gln Arg Cys Ile Pro Glu Phe Phe 

    50                  55                  60                  





Leu Ala Gly Lys Gln Pro Cys Thr Asn Asp Met Ala Lys Ser Asn Ser 

65                  70                  75                  80  





Val Gly Gln Asp Ser Cys Gln Asp Ser Glu Gly Asp Met Ile Phe Pro 

                85                  90                  95      





Ala Glu Ser Ser Cys Ala Leu Pro Gln Glu Gly Ser Ala Gly Pro Gly 

            100                 105                 110         





Ser Pro Gly Ser Ala Pro Pro Ser Arg Lys Arg Ser Trp Ser Ser Glu 

        115                 120                 125             





Glu Glu Ser Asn Gln Ala Thr Gly Thr Ser Arg Trp Asp Gly Val Ser 

    130                 135                 140                 





Lys Lys Ala Pro Arg His His Leu Ser Val Pro Cys Thr Arg Pro Arg 

145                 150                 155                 160 





Glu Ala Arg Gln Glu Ala Glu Asp Ser Thr Ser Arg Leu Ser Ala Glu 

                165                 170                 175     





Ser Gly Glu Thr Asp Gln Asp Ala Gly Asp Val Gly Pro Asp Pro Ile 

            180                 185                 190         





Pro Asp Ser Tyr Tyr Gly Leu Leu Gly Thr Leu Pro Cys Gln Glu Ala 

        195                 200                 205             





Leu Ser His Ile Cys Ser Leu Pro Ser Glu Val Leu Arg His Val Phe 

    210                 215                 220                 





Ala Phe Leu Pro Val Glu Asp Leu Tyr Trp Asn Leu Ser Leu Val Cys 

225                 230                 235                 240 





His Leu Trp Arg Glu Ile Ile Ser Asp Pro Leu Phe Ile Pro Trp Lys 

                245                 250                 255     





Lys Leu Tyr His Arg Tyr Leu Met Asn Glu Glu Gln Ala Val Ser Lys 

            260                 265                 270         





Val Asp Gly Ile Leu Ser Asn Cys Gly Ile Glu Lys Glu Ser Asp Leu 

        275                 280                 285             





Cys Val Leu Asn Leu Ile Arg Tyr Thr Ala Thr Thr Lys Cys Ser Pro 

    290                 295                 300                 





Ser Val Asp Pro Glu Arg Val Leu Trp Ser Leu Arg Asp His Pro Leu 

305                 310                 315                 320 





Leu Pro Glu Ala Glu Ala Cys Val Arg Gln His Leu Pro Asp Leu Tyr 

                325                 330                 335     





Ala Ala Ala Gly Gly Val Asn Ile Trp Ala Leu Val Ala Ala Val Val 

            340                 345                 350         





Leu Leu Ser Ser Ser Val Asn Asp Ile Gln Arg Leu Leu Phe Cys Leu 

        355                 360                 365             





Arg Arg Pro Ser Ser Thr Val Thr Met Pro Asp Val Thr Glu Thr Leu 

    370                 375                 380                 





Tyr Cys Ile Ala Val Leu Leu Tyr Ala Met Arg Glu Lys Gly Ile Asn 

385                 390                 395                 400 





Ile Ser Asn Arg Ile His Tyr Asn Ile Phe Tyr Cys Leu Tyr Leu Gln 

                405                 410                 415     





Glu Asn Ser Cys Thr Gln Ala Thr Lys Val Lys Glu Glu Pro Ser Val 

            420                 425                 430         





Trp Pro Gly Lys Lys Thr Ile Gln Leu Thr His Glu Gln Gln Leu Ile 

        435                 440                 445             





Leu Asn His Lys Met Glu Pro Leu Gln Val Val Lys Ile Met Ala Phe 

    450                 455                 460                 





Ala Gly Thr Gly Lys Thr Ser Thr Leu Val Lys Tyr Ala Glu Lys Trp 

465                 470                 475                 480 





Ser Gln Ser Arg Phe Leu Tyr Val Thr Phe Asn Lys Ser Ile Ala Lys 

                485                 490                 495     





Gln Ala Glu Arg Val Phe Pro Ser Asn Val Ile Cys Lys Thr Phe His 

            500                 505                 510         





Ser Met Ala Tyr Gly His Ile Gly Arg Lys Tyr Gln Ser Lys Lys Lys 

        515                 520                 525             





Leu Asn Leu Phe Lys Leu Thr Pro Phe Met Val Asn Ser Val Leu Ala 

    530                 535                 540                 





Glu Gly Lys Gly Gly Phe Ile Arg Ala Lys Leu Val Cys Lys Thr Leu 

545                 550                 555                 560 





Glu Asn Phe Phe Ala Ser Ala Asp Glu Glu Leu Thr Ile Asp His Val 

                565                 570                 575     





Pro Ile Trp Cys Lys Asn Ser Gln Gly Gln Arg Val Met Val Glu Gln 

            580                 585                 590         





Ser Glu Lys Leu Asn Gly Val Leu Glu Ala Ser Arg Leu Trp Asp Asn 

        595                 600                 605             





Met Arg Lys Leu Gly Glu Cys Thr Glu Glu Ala His Gln Met Thr His 

    610                 615                 620                 





Asp Gly Tyr Leu Lys Leu Trp Gln Leu Ser Lys Pro Ser Leu Ala Ser 

625                 630                 635                 640 





Phe Asp Ala Ile Phe Val Asp Glu Ala Gln Asp Cys Thr Pro Ala Ile 

                645                 650                 655     





Met Asn Ile Val Leu Ser Gln Pro Cys Gly Lys Ile Phe Val Gly Asp 

            660                 665                 670         





Pro His Gln Gln Ile Tyr Thr Phe Arg Gly Ala Val Asn Ala Leu Phe 

        675                 680                 685             





Thr Val Pro His Thr His Val Phe Tyr Leu Thr Gln Ser Phe Arg Phe 

    690                 695                 700                 





Gly Val Glu Ile Ala Tyr Val Gly Ala Thr Ile Leu Asp Val Cys Lys 

705                 710                 715                 720 





Arg Val Arg Lys Lys Thr Leu Val Gly Gly Asn His Gln Ser Gly Ile 

                725                 730                 735     





Arg Gly Asp Ala Lys Gly Gln Val Ala Leu Leu Ser Arg Thr Asn Ala 

            740                 745                 750         





Asn Val Phe Asp Glu Ala Val Arg Val Thr Glu Gly Glu Phe Pro Ser 

        755                 760                 765             





Arg Ile His Leu Ile Gly Gly Ile Lys Ser Phe Gly Leu Asp Arg Ile 

    770                 775                 780                 





Ile Asp Ile Trp Ile Leu Leu Gln Pro Glu Glu Glu Arg Arg Lys Gln 

785                 790                 795                 800 





Asn Leu Val Ile Lys Asp Lys Phe Ile Arg Arg Trp Val His Lys Glu 

                805                 810                 815     





Gly Phe Ser Gly Phe Lys Arg Tyr Val Thr Ala Ala Glu Asp Lys Glu 

            820                 825                 830         





Leu Glu Ala Lys Ile Ala Val Val Glu Lys Tyr Asn Ile Arg Ile Pro 

        835                 840                 845             





Glu Leu Val Gln Arg Ile Glu Lys Cys His Ile Glu Asp Leu Asp Phe 

    850                 855                 860                 





Ala Glu Tyr Ile Leu Gly Thr Val His Lys Ala Lys Gly Leu Glu Phe 

865                 870                 875                 880 





Asp Thr Val His Val Leu Asp Asp Phe Val Lys Val Pro Cys Ala Arg 

                885                 890                 895     





His Asn Leu Pro Gln Leu Pro His Phe Arg Val Glu Ser Phe Ser Glu 

            900                 905                 910         





Asp Glu Trp Asn Leu Leu Tyr Val Ala Val Thr Arg Ala Lys Lys Arg 

        915                 920                 925             





Leu Ile Met Thr Lys Ser Leu Glu Asn Ile Leu Thr Leu Ala Gly Glu 

    930                 935                 940                 





Tyr Phe Leu Gln Ala Glu Leu Thr Ser Asn Val Leu Lys Thr Gly Val 

945                 950                 955                 960 





Val Arg Cys Cys Val Gly Gln Cys Asn Asn Ala Ile Pro Val Asp Thr 

                965                 970                 975     





Val Leu Thr Met Lys Lys Leu Pro Ile Thr Tyr Ser Asn Arg Lys Glu 

            980                 985                 990         





Asn Lys Gly Gly Tyr Leu Cys His  Ser Cys Ala Glu Gln  Arg Ile Gly 

        995                 1000                 1005             





Pro Leu  Ala Phe Leu Thr Ala  Ser Pro Glu Gln Val  Arg Ala Met 

    1010                 1015                 1020             





Glu Arg  Thr Val Glu Asn Ile  Val Leu Pro Arg His  Glu Ala Leu 

    1025                 1030                 1035             





Leu Phe  Leu Val Phe 

    1040             





<210>  84

<211>  9288

<212>  DNA

<213>  Homo sapiens



<400>  84

agtgctcgcc cgcccgaccc cggcggctcg cgcccgggag cgccgcaggg tcgctagagt       60



cggccgcgtc ctttgtgtgg cgctcaggct gcgccgcggg gcggcgggac ggaatgtggg      120



cgctgcgggg gcttttctct cctacccgaa ctgtgggaac aatggactga aaggggaaga      180



tggattgagg ggccgagcgg ggaagcgagc tgcaccgggg aatcatgact tctgcagccg      240



agataaagaa gccaccagtg gcccccaagc ccaagtttgt tgtggcaaat aataagccag      300



ccccacctcc tattgcacct aaacccgaca ttgtgatttc tagtgttcca cagtcgacaa      360



agaaaatgaa accagcaata gccccaaaac caaaagtcct gaagacctca cctgttcgag      420



agattgggca gtcgccatca aggaaaatca tgttgaacct ggaagggcat aaacaggaat      480



tagctgaaag cactgacaac tttaattgta aatatgaagg caatcagagc aatgattata      540



tttcaccaat gtgttcctgc agttctgagt gtatccataa gctgggccat agagagaatt      600



tgtgtgtaaa gcagcttgtt ttagagcccc tggaaatgaa tgaaaattta gaaaacagta      660



aaattgatga gactttgact ataaaaacta ggagtaaatg tgatttgtat ggtgaaaaag      720



ccaagaacca gggtggggtt gttttaaagg caagcgtttt agaagaggag ctcaaagatg      780



ccttaataca ccaaatgcca ccttttattt ctgcacagaa gcacaggccc acagacagcc      840



cagaaatgaa tggtggctgt aattcaaatg gacaattcag aattgaattt gcggatttgt      900



caccttcccc atccagcttt gaaaaagttc ctgatcatca cagttgccac ttacagcttc      960



ctagtgatga atgtgaacat tttgaaactt gccaggatga cagtgaaaaa agcaataatt     1020



gctttcagtc atctgaacta gaggctctgg aaaatgggaa aaggagtact ttaatatctt     1080



cagatggagt tagtaagaaa tcagaagtca aagaccttgg tcccttagaa attcatttag     1140



taccatatac cccaaaattt ccaactccca agcccagaaa gacacgaact gctcgtctgt     1200



tacgccaaaa gtgtgtagat actcctagtg aaagcactga agaaccgggg aattcagaca     1260



gtagctcttc ctgtcttact gaaaatagtt tgaaaatcaa taaaatcagt gttctgcatc     1320



agaatgtttt gtgtaagcag gaacaggtgg ataaaatgaa gctaggaaat aaaagtgaat     1380



tgaatatgga atccaacagt gatgcacagg acttagtcaa ttcacagaaa gccatgtgta     1440



atgaaacaac ttcctttgaa aaaatggcac cttcttttga taaagactct aatttgagtt     1500



ctgacagcac aactgtagat ggttctagta tgtcgcttgc tgtggacgaa gggaccggtt     1560



ttataagatg tactgtatct atgagcctgc ctaagcagct caaattaact tgcaatgaac     1620



atttgcaatc tgggagaaac ctgggagttt ctgcccctca aatgcaaaag gaatctgtta     1680



taaaagagga aaattctcta cgaattgtcc ccaaaaaacc tcaaagacat agcttgcctg     1740



ctacaggagt gcttaaaaag gctgcctccg aggagctttt ggaaaaaagt tcttatcctt     1800



caagtgaaga aaaaagttca gagaagagtc tagaaagaaa tcaccttcag catttgtgtg     1860



cccaaaaccg tggtgtgtca tcctcctttg atatgcctaa acgggcttca gaaaagccag     1920



tgtggaagtt acctcatcct attttaccct tttcagggaa cccagaattc ttaaagtctg     1980



tcaccgtatc gtcaaacagt gagccttcaa cagccctaac caagcccaga gcaaaatcgt     2040



tatctgctat ggatgtggaa aagtgcacta agccttgcaa agactctaca aagaaaaact     2100



cttttaaaaa gttgctcagc atgaaactgt ccatctgttt catgaagagt gactttcaaa     2160



aattttggtc caagagtagc caactcggag acaccaccac aggccacctc tccagtgggg     2220



agcagaaggg gattgaaagt gattggcaag gcttgttggt aggagaggag aagagaagta     2280



aacccatcaa ggcatattcc acagaaaact atagcctgga atctcaaaag aagaggaaga     2340



agtctcgggg ccagaccagt gcagctaatg gtctgagagc tgagtctttg gatgaccaaa     2400



tgctctcccg ggagtcatca tctcaggcac cttacaagtc tgttacaagc ctctgtgcac     2460



cggagtatga aaatatacgc cattatgagg aaataccaga gtacgagaac ttgccattta     2520



ttatggctat acggaaaact caagagttgg aatggcagaa ttccagcagc atggaggacg     2580



ctgatgcaaa tgtgtatgag gtagaagagc cgtatgaagc tccagatggc cagctgcagc     2640



ttggacccag acatcagcat tccagttcag gagcatccca ggaggaacag aatgatcttg     2700



gtcttggtga ccttccctct gatgaggagg aaatcatcaa cagttctgat gaagatgatg     2760



tcagctctga gtcaagtaaa ggagagcctg acccactgga agataaacag gatgaagata     2820



atggaatgaa aagtaaagtt catcatattg ccaaggagat catgagctca gagaaagtgt     2880



ttgtggatgt gttaaaactt ttgcatattg atttccggga tgcagtagct catgcttcca     2940



ggcaacttgg gaaaccagtg attgaggacc ggattctaaa tcagatccta tactacttgc     3000



ctcagctgta tgagctcaac cgggatctct tgaaggaact ggaggaaaga atgttgcact     3060



ggactgaaca acaaagaatt gctgatatct ttgtaaagaa gggaccatat ctaaaaatgt     3120



attccacata catcaaagaa tttgataaga atatagcctt gctggatgaa cagtgcaaga     3180



aaaatccagg ttttgctgct gttgttagag aatttgagat gagccctcgc tgtgctaatc     3240



tggccctcaa gcactacctg ctcaagccgg ttcagaggat cccccagtac aggctgttgc     3300



tgacagatta tttgaagaat ctcatagaag atgctggaga ttacagagac actcaagatg     3360



cccttgctgt tgttatagag gtagccaacc acgccaatga caccatgaag caaggagaca     3420



actttcagaa acttatgcaa attcagtaca gcttaaatgg acaccatgaa attgtgcagc     3480



ctggtcgggt ttttctcaaa gaaggaattc tgatgaagct gtctcggaaa gtgatgcaac     3540



ctcgaatgtt tttcctgttt aatgatgccc tgctgtatac aacaccagtg cagtctggga     3600



tgtataaact gaacaacatg ctctcactgg ctggaatgaa ggtcagaaaa cctacccaag     3660



aagcctatca gaatgaatta aagattgaaa gtgtagaacg ttccttcatt ctctcagcca     3720



gttctgccac agaaagggat gaatggctag aagcgatttc cagggcaata gaagagtatg     3780



ccaagaaaag aatcaccttc tgtcctagta ggagtcttga tgaggcagac tcagaaaata     3840



aagaagaagt tagtcctctt ggatcgaagg ctcccatctg gattcctgat accagagcca     3900



caatgtgtat gatctgcaca agcgaattca ctctcacctg gagacgacac cactgccggg     3960



cctgtggaaa gattgtatgc caagcttgtt cgtctaataa gtatggctta gattacctga     4020



aaaatcaacc agcaagagta tgtgaacatt gtttccaaga actgcagaaa ttagatcacc     4080



agcactcccc taggattgga tctcctggaa atcacaaatc tccttcaagt gccttatcat     4140



cagtcttaca tagcattcca tcagggagga aacagaaaaa aatcccagct gctctcaaag     4200



aagtatcagc aaacacagag gattcttcta tgagtggcta cttgtacaga tcaaagggca     4260



ataaaaaacc ctggaaacac ttttggtttg tcataaaaaa taaagtacta tatacatatg     4320



ctgcaagtga ggacgtggcc gctttggaga gtcagccttt attaggattc actgttattc     4380



aagttaaaga tgagaattcc gagtctaaag tatttcagtt actgcacaaa aacatgttat     4440



tttatgtatt caaagcagag gatgctcatt cggctcagaa gtggatagaa gcatttcagg     4500



aaggcacaat attgtagcag tattggtttc atctcttctg tgattccaaa gaggtggaat     4560



ttcatcagaa tggagtaaat gcaattcaaa aattgtataa aaatgaacac tgccaagata     4620



aagccaacca gacccttcat caaagaaatt gttttgttag gtataagcaa tttttaaaag     4680



gtgtttgttt tttcatttat gttatttatt aaaattttga tgtttactta atggtcagaa     4740



ttatttctga gacacactga attctaaagt accatttctt tagagaccag aaaaactatc     4800



ttaatactgt atactgtatt aactattcgt gacatagttc acactgtttt cttaccttac     4860



attgtaacaa tcttactggt ggaaagtctt tgtaaggaaa aaacacatag caaggagcaa     4920



atttccacaa agtgcttggt ttaggaattg tgattattat aaaactgctg atgaaaaaaa     4980



tgcatgtctt tgaatcaata aacttgggtg aatatttgta tcttttagtg gaaaaacatg     5040



gccagcttct acctcagtaa ctgtgaactg aaatttcagt aaattatcta aagtatttct     5100



gttgttaggt acctctttgg caggagttaa tattacatca tcaaagaatt atagcaaaga     5160



gatagaatct gaatttttta aaactgtgag taggaatgaa gatgttttta tttgcagaat     5220



accacaaata accaactctt ccggctttta agtccaatct tttaaaaaat ctaccacttc     5280



gaaacaaaca taaatgtatc attttttaaa atagcaaaat atagcaagca ttatgtcaca     5340



taatattccc tgctattata agagttctga gcccaagtca atgatgatat ttgtatctat     5400



aagtaatgtt acatttccaa aaatattgtg cattacaaat ggaactggaa ttactatatc     5460



agaaaagcat aattataagc cagtaataac tgaaattcta tagtattcat tttcaaaagg     5520



tctttttctg ccagtttgtg atatcctccc tcctaattaa aaaaaaaaac aacaaatcct     5580



ttctctataa gcagctatca gcacacctcc ttaggaaaga tttagattca taattctggt     5640



gcacttactg tttaacatat gaactacctt gcacatacaa ttgttgatta gcagaagaaa     5700



atgaaataac actgtgataa aagccatccc tgatgttcac aatacacaat ttattaacta     5760



agtttaaact ataaattatc ttaactgcca tgagcggtgg ctcacaccta caatctcagc     5820



attttgggag gccgaggccg ttggaccacc tgaggtcagg agatcgagac cagcctggcc     5880



aatatggtga aaccccatct ctattaaaaa tacaagaatt agccggtcgt ggtggtacat     5940



ggctgtagtc ctagctattc agcaggctga ggcaggagca tcgcttgaac ccaggaggca     6000



gaggttgcag tgagccgaga tggtgccact gcactccagc ctgggatgac agagcgagac     6060



tccatctcaa aaaaaaaaaa aaaaaaaaaa ttgaacagca aggttatcca tataatattt     6120



ctttaaaggg tacaagaatt ttcctttctg cctctaaata aaggatttcc taattcagtg     6180



tgatccttaa cagcaaccat gaggattact gagtgccttt ctggggcctt ttgaatgctg     6240



tttggtacag caccagagtc cctactagat ctagagttgg ctgctatagt tttttgtggc     6300



gattttttgc catggagtca tttgaacctc atacacaatc ctaacatgcc atcccctttc     6360



tgtcatagca ggtacactaa aatttctttg tagctcaatt ttatataatc aagatcacat     6420



aaataaggct tccatgttag aatcgttgca gtttttagtg tattcctttt tggaggctaa     6480



agttgtacct tataaactgt ttctgcgtct ggcatttagc aagacaagtt atttgggttt     6540



tctttccctc ctcttgagct ctcagccttc tgactacaag gtttggctta agccttataa     6600



tctaaaaaat atcagccagg ctattctatc ttctaagacc tggctgaatc atgagccagt     6660



tctaaatcta aagagagtga gagagggaag aaatctggca caaacttaca gtctctttaa     6720



ttacatgtaa aatgcatgtg actgtattac ctattggctt agccccatgg agggtttaga     6780



aaaatgtgta gtctttgtgg aagctatcca attatccttc tcccaaaaag atgttttaaa     6840



tgtggaatag tattacattc ccctgcccct ttatgagtcc ttcataactt actaaagctg     6900



accaattgtt atttatgtaa cctggctcat tcattgtcaa ctaagaacct aattatatgc     6960



aatttattgt aaaaaaagct ataaaaatat attttgctag tattttagag gaaaaatgat     7020



attgggcaca gtctataaat ggggagaaaa gttaagtagt atctagattc caaggatact     7080



atatttatta tacagatatg tgtgcctgtg cttccatcaa accctttttc aggtatctcc     7140



ttttaattca taaggaggaa agagtagggc atttataaag ctaagctaaa aatgatgcta     7200



agcataacgt agatgagacg ccaggctgaa ccaggggaag gctggcattg ttagtgtccc     7260



caactagcag tccaccttta tctgtggcag ctataaatgt acaggaccca tcagagtcct     7320



aagaaaatga gagtaattat ctctggcatc atccacattt ccgactcttt ccaatctctt     7380



ttcccttttt ctgtaatgta cccagcatcc ccctattgta ttttggttgc ccaagattct     7440



tgattctttg agtgtgtagt agcatttctt aaaatgagat catcagacca acccttgatt     7500



cacatgaaag ctgtaatgac acaacaaaga gaaggcgaca gttttaaagt ataattgtca     7560



gccaaatgtg tattttatat ttggttcata gaatatatct agatgtgggg aaagtctcct     7620



atttggtaat ttagttaaaa tgtaaatgtt atatcacagc atatgttggt atgttttgga     7680



gtgtgcttcc attgtgctca gcttttgaaa agtttgaaat ccactttagt caaatgtagt     7740



caatgggatt tccagagata catattgttt ttcttagtgt accacacact ccttgaaggc     7800



agatactgta cttaatatat cactgtcttc cataatactg ccctaggtct ttttagtttt     7860



taagagaccg ggtctcgcta tgtttcccat gctgaactca aatgcctggg cttaagcaat     7920



cctcccacct cagcctctgg agtagctggg actacagggg catgcaccac caggcctggc     7980



ttcctaggag ggtctttaaa gagaaaatat ttgttcaatt gaaaacagga ttcttgtcat     8040



ctacaactcc aacacagcct gaaaatatcc acattataac ctggacctta gacctacttt     8100



ctccactatc ctgcaaagct acatctgtaa ctacctattg gctatctata tgagtcctca     8160



agcatctcag actttacatg aataaaactc aacttccttc ccattcaaat ctgtttattt     8220



tcttctgtaa gagaaagata ccatttgaga ctccagaatc tgcctctaac tctcaacaag     8280



actctgcaat tactcaagta tcctttccat cctcattgcc ctgctgttat tacataggcc     8340



ctggttcaag tccttgttac ttgttcccat tattgcaata acttctaatt ccaatgccgt     8400



tgtgtgatcc cattttaaac acggccagag cagtcttcca acaacatagc tctaatctag     8460



tttcatcccc acttttacat gcctcagtgg ctttcccagt gacttggcat ggaacacgtc     8520



ctcagttgcc atacattcca gctaactctt acccaacctt tctttgttca cacagtttcc     8580



ttttccttcc tcattgaccc atccgcatct ctgtttatcc aagacttctc tgtgatagct     8640



gacccttagt ctttctctcc cctattcctc cagactagat cctgtctcct tcctgcagcc     8700



ccgacacagc cttcagttca tatcttttgc atgatgctta gcaccttcta tccctaagga     8760



caacttactc atttgagatt tctggcaggg taccttgcat gcagtggaca ctcagtattt     8820



gctgaattaa attccttcct atggatccct tctgattttt tttaagtgcc tctaatacac     8880



atatcattct agggctcatg ccacttttaa tgtcattttc taaaggaaaa tcttatctat     8940



gatattttcc cttataagag atagttgttt tgagtagggt tttttaaaag ataaaggtag     9000



taggaaattt tttaaagcct aaatatcaaa ttcctttccc tttggagttg ggggaaggaa     9060



tgaaggggga gcaacttgct ctttcatatg agttggtcat agcatgtaag aaccaatctt     9120



gaaatatcgt ttttttttta atggcttata atgtatttct agaaatactt tgtacttaaa     9180



atgataacag tttgtatctt tttgtccata tatactttat aaataaaaaa attagcattg     9240



taaataatgt taatatgtat ttatacaaaa taaatttact ataatata                  9288





<210>  85

<211>  1430

<212>  PRT

<213>  Homo sapiens



<400>  85



Met Thr Ser Ala Ala Glu Ile Lys Lys Pro Pro Val Ala Pro Lys Pro 

1               5                   10                  15      





Lys Phe Val Val Ala Asn Asn Lys Pro Ala Pro Pro Pro Ile Ala Pro 

            20                  25                  30          





Lys Pro Asp Ile Val Ile Ser Ser Val Pro Gln Ser Thr Lys Lys Met 

        35                  40                  45              





Lys Pro Ala Ile Ala Pro Lys Pro Lys Val Leu Lys Thr Ser Pro Val 

    50                  55                  60                  





Arg Glu Ile Gly Gln Ser Pro Ser Arg Lys Ile Met Leu Asn Leu Glu 

65                  70                  75                  80  





Gly His Lys Gln Glu Leu Ala Glu Ser Thr Asp Asn Phe Asn Cys Lys 

                85                  90                  95      





Tyr Glu Gly Asn Gln Ser Asn Asp Tyr Ile Ser Pro Met Cys Ser Cys 

            100                 105                 110         





Ser Ser Glu Cys Ile His Lys Leu Gly His Arg Glu Asn Leu Cys Val 

        115                 120                 125             





Lys Gln Leu Val Leu Glu Pro Leu Glu Met Asn Glu Asn Leu Glu Asn 

    130                 135                 140                 





Ser Lys Ile Asp Glu Thr Leu Thr Ile Lys Thr Arg Ser Lys Cys Asp 

145                 150                 155                 160 





Leu Tyr Gly Glu Lys Ala Lys Asn Gln Gly Gly Val Val Leu Lys Ala 

                165                 170                 175     





Ser Val Leu Glu Glu Glu Leu Lys Asp Ala Leu Ile His Gln Met Pro 

            180                 185                 190         





Pro Phe Ile Ser Ala Gln Lys His Arg Pro Thr Asp Ser Pro Glu Met 

        195                 200                 205             





Asn Gly Gly Cys Asn Ser Asn Gly Gln Phe Arg Ile Glu Phe Ala Asp 

    210                 215                 220                 





Leu Ser Pro Ser Pro Ser Ser Phe Glu Lys Val Pro Asp His His Ser 

225                 230                 235                 240 





Cys His Leu Gln Leu Pro Ser Asp Glu Cys Glu His Phe Glu Thr Cys 

                245                 250                 255     





Gln Asp Asp Ser Glu Lys Ser Asn Asn Cys Phe Gln Ser Ser Glu Leu 

            260                 265                 270         





Glu Ala Leu Glu Asn Gly Lys Arg Ser Thr Leu Ile Ser Ser Asp Gly 

        275                 280                 285             





Val Ser Lys Lys Ser Glu Val Lys Asp Leu Gly Pro Leu Glu Ile His 

    290                 295                 300                 





Leu Val Pro Tyr Thr Pro Lys Phe Pro Thr Pro Lys Pro Arg Lys Thr 

305                 310                 315                 320 





Arg Thr Ala Arg Leu Leu Arg Gln Lys Cys Val Asp Thr Pro Ser Glu 

                325                 330                 335     





Ser Thr Glu Glu Pro Gly Asn Ser Asp Ser Ser Ser Ser Cys Leu Thr 

            340                 345                 350         





Glu Asn Ser Leu Lys Ile Asn Lys Ile Ser Val Leu His Gln Asn Val 

        355                 360                 365             





Leu Cys Lys Gln Glu Gln Val Asp Lys Met Lys Leu Gly Asn Lys Ser 

    370                 375                 380                 





Glu Leu Asn Met Glu Ser Asn Ser Asp Ala Gln Asp Leu Val Asn Ser 

385                 390                 395                 400 





Gln Lys Ala Met Cys Asn Glu Thr Thr Ser Phe Glu Lys Met Ala Pro 

                405                 410                 415     





Ser Phe Asp Lys Asp Ser Asn Leu Ser Ser Asp Ser Thr Thr Val Asp 

            420                 425                 430         





Gly Ser Ser Met Ser Leu Ala Val Asp Glu Gly Thr Gly Phe Ile Arg 

        435                 440                 445             





Cys Thr Val Ser Met Ser Leu Pro Lys Gln Leu Lys Leu Thr Cys Asn 

    450                 455                 460                 





Glu His Leu Gln Ser Gly Arg Asn Leu Gly Val Ser Ala Pro Gln Met 

465                 470                 475                 480 





Gln Lys Glu Ser Val Ile Lys Glu Glu Asn Ser Leu Arg Ile Val Pro 

                485                 490                 495     





Lys Lys Pro Gln Arg His Ser Leu Pro Ala Thr Gly Val Leu Lys Lys 

            500                 505                 510         





Ala Ala Ser Glu Glu Leu Leu Glu Lys Ser Ser Tyr Pro Ser Ser Glu 

        515                 520                 525             





Glu Lys Ser Ser Glu Lys Ser Leu Glu Arg Asn His Leu Gln His Leu 

    530                 535                 540                 





Cys Ala Gln Asn Arg Gly Val Ser Ser Ser Phe Asp Met Pro Lys Arg 

545                 550                 555                 560 





Ala Ser Glu Lys Pro Val Trp Lys Leu Pro His Pro Ile Leu Pro Phe 

                565                 570                 575     





Ser Gly Asn Pro Glu Phe Leu Lys Ser Val Thr Val Ser Ser Asn Ser 

            580                 585                 590         





Glu Pro Ser Thr Ala Leu Thr Lys Pro Arg Ala Lys Ser Leu Ser Ala 

        595                 600                 605             





Met Asp Val Glu Lys Cys Thr Lys Pro Cys Lys Asp Ser Thr Lys Lys 

    610                 615                 620                 





Asn Ser Phe Lys Lys Leu Leu Ser Met Lys Leu Ser Ile Cys Phe Met 

625                 630                 635                 640 





Lys Ser Asp Phe Gln Lys Phe Trp Ser Lys Ser Ser Gln Leu Gly Asp 

                645                 650                 655     





Thr Thr Thr Gly His Leu Ser Ser Gly Glu Gln Lys Gly Ile Glu Ser 

            660                 665                 670         





Asp Trp Gln Gly Leu Leu Val Gly Glu Glu Lys Arg Ser Lys Pro Ile 

        675                 680                 685             





Lys Ala Tyr Ser Thr Glu Asn Tyr Ser Leu Glu Ser Gln Lys Lys Arg 

    690                 695                 700                 





Lys Lys Ser Arg Gly Gln Thr Ser Ala Ala Asn Gly Leu Arg Ala Glu 

705                 710                 715                 720 





Ser Leu Asp Asp Gln Met Leu Ser Arg Glu Ser Ser Ser Gln Ala Pro 

                725                 730                 735     





Tyr Lys Ser Val Thr Ser Leu Cys Ala Pro Glu Tyr Glu Asn Ile Arg 

            740                 745                 750         





His Tyr Glu Glu Ile Pro Glu Tyr Glu Asn Leu Pro Phe Ile Met Ala 

        755                 760                 765             





Ile Arg Lys Thr Gln Glu Leu Glu Trp Gln Asn Ser Ser Ser Met Glu 

    770                 775                 780                 





Asp Ala Asp Ala Asn Val Tyr Glu Val Glu Glu Pro Tyr Glu Ala Pro 

785                 790                 795                 800 





Asp Gly Gln Leu Gln Leu Gly Pro Arg His Gln His Ser Ser Ser Gly 

                805                 810                 815     





Ala Ser Gln Glu Glu Gln Asn Asp Leu Gly Leu Gly Asp Leu Pro Ser 

            820                 825                 830         





Asp Glu Glu Glu Ile Ile Asn Ser Ser Asp Glu Asp Asp Val Ser Ser 

        835                 840                 845             





Glu Ser Ser Lys Gly Glu Pro Asp Pro Leu Glu Asp Lys Gln Asp Glu 

    850                 855                 860                 





Asp Asn Gly Met Lys Ser Lys Val His His Ile Ala Lys Glu Ile Met 

865                 870                 875                 880 





Ser Ser Glu Lys Val Phe Val Asp Val Leu Lys Leu Leu His Ile Asp 

                885                 890                 895     





Phe Arg Asp Ala Val Ala His Ala Ser Arg Gln Leu Gly Lys Pro Val 

            900                 905                 910         





Ile Glu Asp Arg Ile Leu Asn Gln Ile Leu Tyr Tyr Leu Pro Gln Leu 

        915                 920                 925             





Tyr Glu Leu Asn Arg Asp Leu Leu Lys Glu Leu Glu Glu Arg Met Leu 

    930                 935                 940                 





His Trp Thr Glu Gln Gln Arg Ile Ala Asp Ile Phe Val Lys Lys Gly 

945                 950                 955                 960 





Pro Tyr Leu Lys Met Tyr Ser Thr Tyr Ile Lys Glu Phe Asp Lys Asn 

                965                 970                 975     





Ile Ala Leu Leu Asp Glu Gln Cys Lys Lys Asn Pro Gly Phe Ala Ala 

            980                 985                 990         





Val Val Arg Glu Phe Glu Met Ser  Pro Arg Cys Ala Asn  Leu Ala Leu 

        995                 1000                 1005             





Lys His  Tyr Leu Leu Lys Pro  Val Gln Arg Ile Pro  Gln Tyr Arg 

    1010                 1015                 1020             





Leu Leu  Leu Thr Asp Tyr Leu  Lys Asn Leu Ile Glu  Asp Ala Gly 

    1025                 1030                 1035             





Asp Tyr  Arg Asp Thr Gln Asp  Ala Leu Ala Val Val  Ile Glu Val 

    1040                 1045                 1050             





Ala Asn  His Ala Asn Asp Thr  Met Lys Gln Gly Asp  Asn Phe Gln 

    1055                 1060                 1065             





Lys Leu  Met Gln Ile Gln Tyr  Ser Leu Asn Gly His  His Glu Ile 

    1070                 1075                 1080             





Val Gln  Pro Gly Arg Val Phe  Leu Lys Glu Gly Ile  Leu Met Lys 

    1085                 1090                 1095             





Leu Ser  Arg Lys Val Met Gln  Pro Arg Met Phe Phe  Leu Phe Asn 

    1100                 1105                 1110             





Asp Ala  Leu Leu Tyr Thr Thr  Pro Val Gln Ser Gly  Met Tyr Lys 

    1115                 1120                 1125             





Leu Asn  Asn Met Leu Ser Leu  Ala Gly Met Lys Val  Arg Lys Pro 

    1130                 1135                 1140             





Thr Gln  Glu Ala Tyr Gln Asn  Glu Leu Lys Ile Glu  Ser Val Glu 

    1145                 1150                 1155             





Arg Ser  Phe Ile Leu Ser Ala  Ser Ser Ala Thr Glu  Arg Asp Glu 

    1160                 1165                 1170             





Trp Leu  Glu Ala Ile Ser Arg  Ala Ile Glu Glu Tyr  Ala Lys Lys 

    1175                 1180                 1185             





Arg Ile  Thr Phe Cys Pro Ser  Arg Ser Leu Asp Glu  Ala Asp Ser 

    1190                 1195                 1200             





Glu Asn  Lys Glu Glu Val Ser  Pro Leu Gly Ser Lys  Ala Pro Ile 

    1205                 1210                 1215             





Trp Ile  Pro Asp Thr Arg Ala  Thr Met Cys Met Ile  Cys Thr Ser 

    1220                 1225                 1230             





Glu Phe  Thr Leu Thr Trp Arg  Arg His His Cys Arg  Ala Cys Gly 

    1235                 1240                 1245             





Lys Ile  Val Cys Gln Ala Cys  Ser Ser Asn Lys Tyr  Gly Leu Asp 

    1250                 1255                 1260             





Tyr Leu  Lys Asn Gln Pro Ala  Arg Val Cys Glu His  Cys Phe Gln 

    1265                 1270                 1275             





Glu Leu  Gln Lys Leu Asp His  Gln His Ser Pro Arg  Ile Gly Ser 

    1280                 1285                 1290             





Pro Gly  Asn His Lys Ser Pro  Ser Ser Ala Leu Ser  Ser Val Leu 

    1295                 1300                 1305             





His Ser  Ile Pro Ser Gly Arg  Lys Gln Lys Lys Ile  Pro Ala Ala 

    1310                 1315                 1320             





Leu Lys  Glu Val Ser Ala Asn  Thr Glu Asp Ser Ser  Met Ser Gly 

    1325                 1330                 1335             





Tyr Leu  Tyr Arg Ser Lys Gly  Asn Lys Lys Pro Trp  Lys His Phe 

    1340                 1345                 1350             





Trp Phe  Val Ile Lys Asn Lys  Val Leu Tyr Thr Tyr  Ala Ala Ser 

    1355                 1360                 1365             





Glu Asp  Val Ala Ala Leu Glu  Ser Gln Pro Leu Leu  Gly Phe Thr 

    1370                 1375                 1380             





Val Ile  Gln Val Lys Asp Glu  Asn Ser Glu Ser Lys  Val Phe Gln 

    1385                 1390                 1395             





Leu Leu  His Lys Asn Met Leu  Phe Tyr Val Phe Lys  Ala Glu Asp 

    1400                 1405                 1410             





Ala His  Ser Ala Gln Lys Trp  Ile Glu Ala Phe Gln  Glu Gly Thr 

    1415                 1420                 1425             





Ile Leu  

    1430 





<210>  86

<211>  1738

<212>  DNA

<213>  Homo sapiens



<400>  86

ggcgggcccg cgctcacttc ctcggggagg ggttggggcc gcgctcccac tcgcccacac       60



ggtccgtctg cagtcggcag cctcgccggc agctcgctcg gcccccgctt ggcccggccc      120



gcaggtagga gccgccgagg gacgcggcgc ccggttcccg gccccgcctg cgccgcgcgc      180



tccccgctcc cgccgcccgc ttcgagggtt ctctcccctt gccaccatga gcgagtcatt      240



tgactgtgca aaatgcaacg agtccctgta tggacgcaag tacatccaga cagacagcgg      300



cccctactgt gtgccctgct atgacaatac ctttgccaac acctgtgctg agtgccagca      360



gcttatcggg catgactcga gggagctgtt ctatgaagac cgccatttcc acgagggctg      420



cttccgctgc tgccgctgcc agcgctcact agccgatgaa cccttcacct gccaggacag      480



tgagctgctc tgcaatgact gctactgcag tgcgttttcc tcgcagtgct ccgcttgtgg      540



ggagactgtc atgcctgggt cccggaagct ggaatatgga ggccagacat ggcatgagca      600



ctgcttcctg tgcagtggct gtgaacagcc actgggctcc cgttcttttg tgcccgacaa      660



gggtgctcac tactgcgtgc cctgctatga gaacaagttt gctcctcgct gcgcccgctg      720



cagcaagacg ctgacacagg gtggagtgac ataccgtgat cagccgtggc atcgagaatg      780



tctggtctgt accggatgcc agacgcccct ggcagggcag cagttcacct cccgggatga      840



agatccctac tgtgtggcct gttttggaga actctttgca cctaagtgca gcagctgcaa      900



gcgccccatc gtaggactcg gtggaggcaa gtatgtgtcc tttgaagacc gacactggca      960



ccacaactgc ttctcctgcg cccgctgctc tacctccctg gtgggccagg gcttcgtacc     1020



ggatggagac caagtgctct gccagggctg tagccaggca gggccctaag ccagggctcc     1080



tggacccagg ctttcccata ccacgggccc aggactgtgg ctccttttct aaaccacctc     1140



tgggactcag ctccccccgc caaaaaaaat gggtctcctt ctgggctcca ggattgtctc     1200



cccactccag catccccaaa ctggtactcc ctgacccagg cccccaatcc tgggctctta     1260



cagagcctcc atgagtcaag ccccctcccc acacctggac tccagaattc accctctccc     1320



ctgcagtctg ggttcccaga ctgagtcctc tccccaaatc agggctctag acccgagccc     1380



tccaaacctg gactctggga cttaggcccc cttaaatcta gacttctctt tataggtttc     1440



aggtctccta tgggtgcctg ggaagtcctt gaaagtggac tgttctcagg cttgacctgc     1500



cccaccccat ccccgcggtt gaggctgtgg gggcagcaga tcaggagccc actgataagg     1560



ggccctaggg tacagggtgc tgcccagcag gtcgccaccg agtgtcttct cattttattt     1620



cagctccatt ttgcccatag atgggcagag gggtgagatt ggctcatccc ccttccagat     1680



tctgcaataa agcggtgtga ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa       1738





<210>  87

<211>  280

<212>  PRT

<213>  Homo sapiens



<400>  87



Met Ser Glu Ser Phe Asp Cys Ala Lys Cys Asn Glu Ser Leu Tyr Gly 

1               5                   10                  15      





Arg Lys Tyr Ile Gln Thr Asp Ser Gly Pro Tyr Cys Val Pro Cys Tyr 

            20                  25                  30          





Asp Asn Thr Phe Ala Asn Thr Cys Ala Glu Cys Gln Gln Leu Ile Gly 

        35                  40                  45              





His Asp Ser Arg Glu Leu Phe Tyr Glu Asp Arg His Phe His Glu Gly 

    50                  55                  60                  





Cys Phe Arg Cys Cys Arg Cys Gln Arg Ser Leu Ala Asp Glu Pro Phe 

65                  70                  75                  80  





Thr Cys Gln Asp Ser Glu Leu Leu Cys Asn Asp Cys Tyr Cys Ser Ala 

                85                  90                  95      





Phe Ser Ser Gln Cys Ser Ala Cys Gly Glu Thr Val Met Pro Gly Ser 

            100                 105                 110         





Arg Lys Leu Glu Tyr Gly Gly Gln Thr Trp His Glu His Cys Phe Leu 

        115                 120                 125             





Cys Ser Gly Cys Glu Gln Pro Leu Gly Ser Arg Ser Phe Val Pro Asp 

    130                 135                 140                 





Lys Gly Ala His Tyr Cys Val Pro Cys Tyr Glu Asn Lys Phe Ala Pro 

145                 150                 155                 160 





Arg Cys Ala Arg Cys Ser Lys Thr Leu Thr Gln Gly Gly Val Thr Tyr 

                165                 170                 175     





Arg Asp Gln Pro Trp His Arg Glu Cys Leu Val Cys Thr Gly Cys Gln 

            180                 185                 190         





Thr Pro Leu Ala Gly Gln Gln Phe Thr Ser Arg Asp Glu Asp Pro Tyr 

        195                 200                 205             





Cys Val Ala Cys Phe Gly Glu Leu Phe Ala Pro Lys Cys Ser Ser Cys 

    210                 215                 220                 





Lys Arg Pro Ile Val Gly Leu Gly Gly Gly Lys Tyr Val Ser Phe Glu 

225                 230                 235                 240 





Asp Arg His Trp His His Asn Cys Phe Ser Cys Ala Arg Cys Ser Thr 

                245                 250                 255     





Ser Leu Val Gly Gln Gly Phe Val Pro Asp Gly Asp Gln Val Leu Cys 

            260                 265                 270         





Gln Gly Cys Ser Gln Ala Gly Pro 

        275                 280 





<210>  88

<211>  521

<212>  DNA

<213>  Homo sapiens



<400>  88

acgattatct tccaggacct catcagccac aatgagatgt tctctgacat ttacaagatc       60



tgggagatca caaatgggct gtgcctggaa gtggagcaga agatgctcag taagacaaca      120



gggaacactg atgactcact cattggcaga aattcctcct ctgaaagtac tgaggatgaa      180



gttactgaaa gcacgataat cactagtgtt gatattgtta caaaccatca cttgcaggaa      240



agcatcttca caaaagaagc ctacaagaag tatatcaaag attacatgaa atcaatcaac      300



gaaaaacttg aagaacagag accagaaaga gtgaaacttt ttataacagg aatgaagaac      360



aaatcaagca catctttgct aattttcaaa actaccagtt ctttattggt gaaaacctaa      420



atccacctgg catggttgct ctgctgaact accgtaagga tggtcagtat gaccccatat      480



atgatttttt aaggaatggt ttagaaatta aaagatgtta a                          521





<210>  89

<211>  127

<212>  PRT

<213>  Homo sapiens



<400>  89



Met Phe Ser Asp Ile Tyr Lys Ile Trp Glu Ile Thr Asn Gly Leu Cys 

1               5                   10                  15      





Leu Glu Val Glu Gln Lys Met Leu Ser Lys Thr Thr Gly Asn Thr Asp 

            20                  25                  30          





Asp Ser Leu Ile Gly Arg Asn Ser Ser Ser Glu Ser Thr Glu Asp Glu 

        35                  40                  45              





Val Thr Glu Ser Thr Ile Ile Thr Ser Val Asp Ile Val Thr Asn His 

    50                  55                  60                  





His Leu Gln Glu Ser Ile Phe Thr Lys Glu Ala Tyr Lys Lys Tyr Ile 

65                  70                  75                  80  





Lys Asp Tyr Met Lys Ser Ile Asn Glu Lys Leu Glu Glu Gln Arg Pro 

                85                  90                  95      





Glu Arg Val Lys Leu Phe Ile Thr Gly Met Lys Asn Lys Ser Ser Thr 

            100                 105                 110         





Ser Leu Leu Ile Phe Lys Thr Thr Ser Ser Leu Leu Val Lys Thr 

        115                 120                 125         





<210>  90

<211>  1772

<212>  DNA

<213>  Homo sapiens



<400>  90

gcattgtggg aagggcggcc ggtgcagccg cagctgccat cttaggggcg cctggcgcta       60



cgggtttctc gttggaggcg gccttcgtgg cagctgtaga cgccgggaaa aggcataaag      120



tccgttggcc gacacctttc tttcctccgg cctcggtaga accgccagcc cgcgtccgaa      180



ggcggaggcg aggggaactg gccgcgtgag gggcctgagg cgagcggtta gagcgtctcc      240



cggaaggatg ggccggtctc ggagccggag ctcgtcccgc tccaagcaca ccaagagcag      300



caagcacaac aagaagcgca gccggtcccg gtcgcgatcc cgggacaagg agcgcgtgcg      360



gaagcgttcc aaatctcggg aaagtaaacg gaaccggcgg cgggagtcgc ggtcccgttc      420



gcgctccacc aacacggccg tgtcccggcg cgagcgggac cgggagcgcg cctcgtcccc      480



gcccgaccgc atcgacatct tcgggcgcac ggtgagcaag cgcagcagcc tggacgagaa      540



gcagaagcga gaggaggagg agaagaaagc ggagttcgag cggcagcgaa aaattcgaca      600



gcaagaaata gaagaaaaac tcatcgagga agaaacagca cgaagagtag aagaattggt      660



agcaaaaagg gtggaggaag aactggagaa aaggaaggat gaaattgaac gagaagttct      720



ccgaagggtg gaggaagcca aacgcatcat ggaaaagcag ttgctcgaag aactcgagcg      780



acagagacaa gctgagcttg ccgcacaaaa agctagagag gaggaagaac gtgcaaaacg      840



tgaggagcta gagcgaatac tggaagagaa taaccgaaaa attgcagaag cacaagccaa      900



actggccgaa gaacagttga gaattgttga agaacaaaga aagattcatg aggaaaggat      960



gaaactagaa caagaacgac aacgtcaaca aaaagaagaa caaaaaatta tcctgggcaa     1020



ggggaagtcc aggccaaaac tgtccttctc attaaaaacc caggattaaa ttgcaaactc     1080



tgaacttttt acaaagaaaa atggaaaaac tttgtatggt agcttcatgt tgaagtggtt     1140



ttttgttttt gtttttgttt ttttaatttg taaaatctgg aaagttagct tgttctaata     1200



ggggctatgc tctgcaattc cctttttttt tttttttttc cttccactaa gtcaaatcct     1260



tatcagatca ttgttgtatt ctaaggagtg acgtattttt cacctgtttg gattctatat     1320



tagtggtctg aggaagagca gatcacattg taaaactatg gatggtctga taaggctttt     1380



actgacccca ctgacttcag agttatactc tgtttgctac atcataatgc tggttttgct     1440



gactttttgt ttttttatat atttataaaa aaagaaaaag ttggtgattg cattgggaaa     1500



ttcccagggt attactggac ctatgtggtg tattgttaaa ccagtgtcct tgtgatactg     1560



ttgctcttga tgttcctgat acaggtaagg aaacagttgg tcaactctga tacaaagtat     1620



atatacagtt cagtattgtc tctgttcatt ttgtttttat ttcattgaca aaatcaaacc     1680



agcattcccc attgtgtaaa taaatgattt tgctgaataa agtaaagtct taaattcata     1740



tgttgaagca aaaaaaaaaa aaaaaaaaaa aa                                   1772





<210>  91

<211>  273

<212>  PRT

<213>  Homo sapiens



<400>  91



Met Gly Arg Ser Arg Ser Arg Ser Ser Ser Arg Ser Lys His Thr Lys 

1               5                   10                  15      





Ser Ser Lys His Asn Lys Lys Arg Ser Arg Ser Arg Ser Arg Ser Arg 

            20                  25                  30          





Asp Lys Glu Arg Val Arg Lys Arg Ser Lys Ser Arg Glu Ser Lys Arg 

        35                  40                  45              





Asn Arg Arg Arg Glu Ser Arg Ser Arg Ser Arg Ser Thr Asn Thr Ala 

    50                  55                  60                  





Val Ser Arg Arg Glu Arg Asp Arg Glu Arg Ala Ser Ser Pro Pro Asp 

65                  70                  75                  80  





Arg Ile Asp Ile Phe Gly Arg Thr Val Ser Lys Arg Ser Ser Leu Asp 

                85                  90                  95      





Glu Lys Gln Lys Arg Glu Glu Glu Glu Lys Lys Ala Glu Phe Glu Arg 

            100                 105                 110         





Gln Arg Lys Ile Arg Gln Gln Glu Ile Glu Glu Lys Leu Ile Glu Glu 

        115                 120                 125             





Glu Thr Ala Arg Arg Val Glu Glu Leu Val Ala Lys Arg Val Glu Glu 

    130                 135                 140                 





Glu Leu Glu Lys Arg Lys Asp Glu Ile Glu Arg Glu Val Leu Arg Arg 

145                 150                 155                 160 





Val Glu Glu Ala Lys Arg Ile Met Glu Lys Gln Leu Leu Glu Glu Leu 

                165                 170                 175     





Glu Arg Gln Arg Gln Ala Glu Leu Ala Ala Gln Lys Ala Arg Glu Glu 

            180                 185                 190         





Glu Glu Arg Ala Lys Arg Glu Glu Leu Glu Arg Ile Leu Glu Glu Asn 

        195                 200                 205             





Asn Arg Lys Ile Ala Glu Ala Gln Ala Lys Leu Ala Glu Glu Gln Leu 

    210                 215                 220                 





Arg Ile Val Glu Glu Gln Arg Lys Ile His Glu Glu Arg Met Lys Leu 

225                 230                 235                 240 





Glu Gln Glu Arg Gln Arg Gln Gln Lys Glu Glu Gln Lys Ile Ile Leu 

                245                 250                 255     





Gly Lys Gly Lys Ser Arg Pro Lys Leu Ser Phe Ser Leu Lys Thr Gln 

            260                 265                 270         





Asp 

    





<210>  92

<211>  2265

<212>  DNA

<213>  Homo sapiens



<400>  92

gtcagaacta ccccggtagc ctgacagcag gagctcgaga gaagcatggc tcagcggtgc       60



gtttgcgtgc tggccctggt ggctatgctg ctcctagttt tccctaccgt ctccagatcg      120



atgggcccga ggagcgggga gcatcaaagg gcgtcgcgaa tcccttctca gttcagcaaa      180



gaggaacgcg tcgcgatgaa agaggcgctg aaaggtgcca tccagattcc aacagtgact      240



tttagctctg agaagtccaa tactacagcc ctggctgagt tcggaaaata cattcataaa      300



gtctttccta cagtggtcag caccagcttt atccagcatg aagtcgtgga agagtatagc      360



cacctgttca ctatccaagg ctcggacccc agcttgcagc cctacctgct gatggctcac      420



tttgatgtgg tgcctgcccc tgaagaaggc tgggaggtgc ccccattctc tgggttggag      480



cgtgatggcg tcatctatgg tcggggcaca ctggacgaca agaactctgt gatggcatta      540



ctgcaggcct tggagctcct gctgatcagg aagtacatcc cccgaagatc tttcttcatt      600



tctctgggcc atgatgagga gtcatcaggg acaggggctc agaggatctc agccctgcta      660



cagtcaaggg gcgtccagct agccttcatt gtggacgagg ggggcttcat cttggatgat      720



ttcattccta acttcaagaa gcccatcgcc ttgattgcag tctcagagaa gggttccatg      780



aacctcatgc tgcaagtaaa catgacttca ggccactctt cagctcctcc aaaggagaca      840



agcattggca tccttgcagc tgctgtcagc cgattggagc agacaccaat gcctatcata      900



tttggaagcg ggacagtggt gactgtattg cagcaactgg caaatgagtt tcccttccct      960



gtcaatataa tcctgagcaa cccatggcta tttgaaccac ttataagcag gtttatggag     1020



agaaatccct taaccaatgc aataatcagg accaccacgg cactcaccat attcaaagca     1080



ggggtcaagt tcaatgtcat ccccccagtg gcccaggcca cagtcaactt ccggattcac     1140



cctggacaga cagtccaaga ggtcctagaa ctcacgaaga acattgtggc tgataacaga     1200



gtccagttcc atgtgttgag tgcctttgac cccctccccg tcagcccttc tgatgacaag     1260



gccttgggct accagctgct ccgccagacc gtacagtccg tcttcccgga agtcaatatt     1320



actgccccag ttacttctat tggcaacaca gacagccgat tctttacaaa cctcaccact     1380



ggcatctaca ggttctaccc catctacata cagcctgaag acttcaaacg catccatgga     1440



gtcaacgaga aaatctcagt ccaagcctat gagacccaag tgaaattcat ctttgagttg     1500



attcagaatg ctgacacaga ccaggagcca gtttctcacc tgcacaaact gtgaggtcaa     1560



ggggcctgct gggttaggca tgcccgaccc cgggacagga ctaacccaag ggggaaagct     1620



agtgttgatg aaacttttga tcaaaaccac attgtaaaac attgcccatc tgtcttgctc     1680



actcttaaac tctcccaaga acaaggccgg ggtaaggtaa agtcagcaga aatctggctt     1740



ctcccttcct cccgacatct gcatcccttg atccactggc atttgctgcc ctcttgtccc     1800



ttatctgtct tatgctggtt atttcactgc ttcaccttcc aggcttgact taacaaatgt     1860



agatttgaga aatctcaacc agttgttacc tgataggagt ctttaattta gggcactctt     1920



gctgggatgc tttctccaga gcttatatat ttcttcttac tagaactttc ttcccccttt     1980



tattcccctc tcttcttgga ctcatgagct gtctcttcat ctctcctctc tctcctgcat     2040



ctctcccctt actcttcaat ttattctact tctggacctg gacttaccca aactgtgata     2100



ctaccataat tgtcaccata atcagtcaaa taaagtgatc tgtgcatcaa aaaaaaaaaa     2160



aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2220



aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                     2265





<210>  93

<211>  502

<212>  PRT

<213>  Homo sapiens



<400>  93



Met Ala Gln Arg Cys Val Cys Val Leu Ala Leu Val Ala Met Leu Leu 

1               5                   10                  15      





Leu Val Phe Pro Thr Val Ser Arg Ser Met Gly Pro Arg Ser Gly Glu 

            20                  25                  30          





His Gln Arg Ala Ser Arg Ile Pro Ser Gln Phe Ser Lys Glu Glu Arg 

        35                  40                  45              





Val Ala Met Lys Glu Ala Leu Lys Gly Ala Ile Gln Ile Pro Thr Val 

    50                  55                  60                  





Thr Phe Ser Ser Glu Lys Ser Asn Thr Thr Ala Leu Ala Glu Phe Gly 

65                  70                  75                  80  





Lys Tyr Ile His Lys Val Phe Pro Thr Val Val Ser Thr Ser Phe Ile 

                85                  90                  95      





Gln His Glu Val Val Glu Glu Tyr Ser His Leu Phe Thr Ile Gln Gly 

            100                 105                 110         





Ser Asp Pro Ser Leu Gln Pro Tyr Leu Leu Met Ala His Phe Asp Val 

        115                 120                 125             





Val Pro Ala Pro Glu Glu Gly Trp Glu Val Pro Pro Phe Ser Gly Leu 

    130                 135                 140                 





Glu Arg Asp Gly Val Ile Tyr Gly Arg Gly Thr Leu Asp Asp Lys Asn 

145                 150                 155                 160 





Ser Val Met Ala Leu Leu Gln Ala Leu Glu Leu Leu Leu Ile Arg Lys 

                165                 170                 175     





Tyr Ile Pro Arg Arg Ser Phe Phe Ile Ser Leu Gly His Asp Glu Glu 

            180                 185                 190         





Ser Ser Gly Thr Gly Ala Gln Arg Ile Ser Ala Leu Leu Gln Ser Arg 

        195                 200                 205             





Gly Val Gln Leu Ala Phe Ile Val Asp Glu Gly Gly Phe Ile Leu Asp 

    210                 215                 220                 





Asp Phe Ile Pro Asn Phe Lys Lys Pro Ile Ala Leu Ile Ala Val Ser 

225                 230                 235                 240 





Glu Lys Gly Ser Met Asn Leu Met Leu Gln Val Asn Met Thr Ser Gly 

                245                 250                 255     





His Ser Ser Ala Pro Pro Lys Glu Thr Ser Ile Gly Ile Leu Ala Ala 

            260                 265                 270         





Ala Val Ser Arg Leu Glu Gln Thr Pro Met Pro Ile Ile Phe Gly Ser 

        275                 280                 285             





Gly Thr Val Val Thr Val Leu Gln Gln Leu Ala Asn Glu Phe Pro Phe 

    290                 295                 300                 





Pro Val Asn Ile Ile Leu Ser Asn Pro Trp Leu Phe Glu Pro Leu Ile 

305                 310                 315                 320 





Ser Arg Phe Met Glu Arg Asn Pro Leu Thr Asn Ala Ile Ile Arg Thr 

                325                 330                 335     





Thr Thr Ala Leu Thr Ile Phe Lys Ala Gly Val Lys Phe Asn Val Ile 

            340                 345                 350         





Pro Pro Val Ala Gln Ala Thr Val Asn Phe Arg Ile His Pro Gly Gln 

        355                 360                 365             





Thr Val Gln Glu Val Leu Glu Leu Thr Lys Asn Ile Val Ala Asp Asn 

    370                 375                 380                 





Arg Val Gln Phe His Val Leu Ser Ala Phe Asp Pro Leu Pro Val Ser 

385                 390                 395                 400 





Pro Ser Asp Asp Lys Ala Leu Gly Tyr Gln Leu Leu Arg Gln Thr Val 

                405                 410                 415     





Gln Ser Val Phe Pro Glu Val Asn Ile Thr Ala Pro Val Thr Ser Ile 

            420                 425                 430         





Gly Asn Thr Asp Ser Arg Phe Phe Thr Asn Leu Thr Thr Gly Ile Tyr 

        435                 440                 445             





Arg Phe Tyr Pro Ile Tyr Ile Gln Pro Glu Asp Phe Lys Arg Ile His 

    450                 455                 460                 





Gly Val Asn Glu Lys Ile Ser Val Gln Ala Tyr Glu Thr Gln Val Lys 

465                 470                 475                 480 





Phe Ile Phe Glu Leu Ile Gln Asn Ala Asp Thr Asp Gln Glu Pro Val 

                485                 490                 495     





Ser His Leu His Lys Leu 

            500         





<210>  94

<211>  6906

<212>  DNA

<213>  Homo sapiens



<400>  94

aagccaacag gcgagtggcg aaggtggcgg cagcggcggc gggggcagtc accggctagg       60



gcgacggctc cgaggccgag tggcggtccg acagagtcct ccgtgtcctc ccccgcatga      120



cccccttgtg atcagccttt gagcctttcc cacattgaag atggtgaaac tagatattca      180



tactctggct catcacctca agcaggaacg cttatatgta aactctgaga aacagctcat      240



tcagaggctc aatgcagatg tacttaagac agctgaaaag ttgtatcgta cagcatggat      300



tgcgaagcaa cagagaatca atttggatcg gcttatcata accagtgctg aagcttcccc      360



tgctgaatgt tgccaacatg ccaaaatttt ggaagataca caatttgttg atgggtataa      420



gcaattggga tttcaggaga ctgcttatgg agaattcttg agtcgattga gggaaaatcc      480



tcgtcttatt gcctcctctt tggttgctgg agagaaactt aatcaggaga acacacaaag      540



tgttatttac acagttttta cctccctgta tggcaattgc atcatgcaag aagatgaaag      600



ctacctcctt caggttttgc gatacttgat tgaatttgaa cttaaagaaa gtgacaaccc      660



taggcgactt ttgaggagag gaacttgtgc cttcagcatc ttatttaaac ttttttctga      720



aggactgttt tctgccaaac ttttcctcac agccacttta catgagccaa ttatgcaact      780



gcttgttgaa gatgaagatc acctggaaac agatccaaac aagctaattg agaggttctc      840



tccatctcag caggaaaaac tctttggaga gaagggctca gatagattca ggcaaaaagt      900



tcaagaaatg gtggagtcca atgaagcaaa gctagtggct ttggtgaaca aatttattgg      960



ttatctcaaa cagaacacat attgttttcc acatagttta aggtggatcg tgtctcagat     1020



gtacaaaacc ctctcctgtg tagataggct ggaagttggg gaggtcaggg caatgtgtac     1080



tgatctcctg ttggcctgct tcatttgtcc tgcagttgtc aatccagaac aatatggaat     1140



aatttccgat gctcctatta atgaagtagc acgatttaat ctgatgcagg taggccgcct     1200



tttgcagcag ttagcaatga ctggctctga agagggagat ccccgaacaa agagcagcct     1260



tggaaagttt gacaaaagct gtgttgccgc tttccttgat gttgtgattg ggggccgtgc     1320



agtggagacc cctccattgt cttccgtcaa tcttctggaa ggattgagca gaactgtggt     1380



ttatataacc tacagtcagc ttattactct ggtgaatttt atgaagagtg tgatgtctgg     1440



agatcaactg agagaagata gaatggctct tgacaattta ttggcaaacc tacccccggc     1500



caagccagga aaaagtagca gtttagaaat gactccctac aatacacctc agctatctcc     1560



agcaaccact ccagcaaata aaaagaatcg attacctata gcaactcgga gcagaagccg     1620



caccaatatg ctaatggacc tacatatgga ccatgaagga tcatctcaag aaaccatcca     1680



ggaggtgcaa ccagaagagg tgttggtcat ttccttaggt acaggtcccc agcttactcc     1740



agggatgatg tcagaaaatg aggtcctaaa catgcagctt tcggatggag gacaaggaga     1800



tgtccctgtt gatgaaaaca aactccatgg taaacctgat aaaaccttgc gcttttccct     1860



ctgcagtgat aatctggaag gaatatctga aggtccttca aatcgctcca attcagtgtc     1920



ctccctagac ctagaaggag agtctgtgtc agaacttgga gcaggacctt ctggcagtaa     1980



tggagttgaa gctctacagc tgttagaaca tgagcaagct acaacacagg ataaccttga     2040



tgataagcta aggaagtttg aaattcgtga catgatggga ttaacagatg atagggacat     2100



atcagaaaca gtgagtgaga cctggagtac agacgtcttg ggaagtgact ttgaccctaa     2160



tattgatgaa gatcgcttgc aagaaattgc aggtgctgca gcagagaaca tgttaggcag     2220



tttgctgtgc ctcccaggtt cagggtcagt gcttcttgac ccctgcactg gttctaccat     2280



atcagagaca acaagtgaag cttggagtgt agaggtattg ccaagtgact cagaggcccc     2340



agacctaaag caggaggagc gtctgcaaga actggagagc tgttctggac tgggtagcac     2400



atctgatgat acggatgtca gggaggtcag ttcccgcccc agcacaccag gcctcagtgt     2460



tgtgtccggc ataagtgcaa cctctgagga tattcccaat aagattgaag acctgagatc     2520



tgagtgcagc tctgattttg ggggtaaaga ttctgtcact agtccagaca tggatgaaat     2580



aactcacgat tttctttata tacttcagcc aaaacaacat tttcaacaca ttgaagcaga     2640



agcagacatg agaatccagc tgtcttctag tgcccaccag ctgacctctc ctccttctca     2700



gtcagagtct ctgctggcca tgtttgatcc actgtcttca catgaagggg cttctgctgt     2760



ggtaaggcca aaggttcact atgctaggcc atcgcatcca ccaccagatc ccccaatcct     2820



ggaaggagct gtgggaggaa atgaggccag gttgccaaac tttggttccc atgttttaac     2880



tccagctgaa atggaggcat tcaagcaaag gcattcttac cctgagagac tagttcgaag     2940



caggagctct gatatagtat cttctgtccg gagacccatg agtgacccca gctggaaccg     3000



gcgtccagga aatgaagagc gagaactccc tccagctgca gccattggtg ctacttcttt     3060



ggtggctgca cctcattcat catcttcatc cccgagtaag gactcctcaa gaggagagac     3120



tgaagaacgc aaagatagcg atgatgagaa atcagacagg aacagacctt ggtggagaaa     3180



acgttttgtt tcagccatgc ctaaagctcc tataccattt agaaagaaag aaaaacaaga     3240



aaaagacaaa gatgatctgg ggcctgacag attctcaaca ctcacagatg atcccagccc     3300



tagactcagt gcacaagctc aggtggctga ggatattctg gacaaataca ggaatgccat     3360



taaacggacc agccccagtg atggagcaat ggcaaactat gaaagtacag aggttatggg     3420



tgatggtgaa agtgcacatg attctccccg tgacgaagca ctgcagaaca tctcggctga     3480



tgatctccca gactctgcaa gccaagcagc ccacccgcag gattcagctt tctcttacag     3540



agatgcaaaa aagaaactga ggcttgctct ttgctctgcg gactctgttg ccttcccagt     3600



gctgacccat tcaacaagga atggtttacc agaccacaca gacccagaag acaatgaaat     3660



tgtatgcttc ttaaaagttc aaatagctga agcaattaat ttacaagata agaatctaat     3720



ggctcaactt caagaaacaa tgcgctgtgt gtgccgtttt gataatagga cttgtaggaa     3780



actgctggct tcgattgctg aggactacag aaaaagagcc ccatatattg cttatctcac     3840



tcgttgtcga caaggactac agaccacaca ggctcacctg gaaaggctat tgcaaagagt     3900



tttgcgggac aaagaagtgg ccaatcgata ctttaccact gtctgtgtga gattactgct     3960



tgagagcaaa gaaaagaaga tcagggaatt cattcaagac tttcagaaac tcaccgcagc     4020



tgacgataaa actgctcagg tagaagattt tctgcagttt ctttatggtg caatggccca     4080



ggatgtcata tggcaaaacg cgagtgaaga acagcttcaa gatgcacagc tggccattga     4140



gcgaagcgtg atgaaccgga ttttcaagct cgccttctac cctaatcaag atggggacat     4200



acttcgcgac caggttcttc atgaacatat ccagagattg tctaaagtag tgactgcaaa     4260



tcacagagct cttcagatac cagaggttta tcttcgagaa gcaccatggc catctgcaca     4320



atcagaaatc aggacaataa gtgcttataa aaccccccgg gacaaagtgc agtgcatcct     4380



gagaatgtgc tctacgatta tgaacctcct gagcctggcc aatgaggact ctgtccctgg     4440



agcggatgac tttgttcctg tgttggtgtt tgtgttgata aaggcaaatc caccctgttt     4500



gctgtctact gtgcagtata tcagtagctt ttatgctagc tgtctgtctg gagaggagtc     4560



ctattggtgg atgcagttca cagcagcagt agaattcatt aaaaccatcg atgaccgaaa     4620



gtgaccaaga ccaaggccca ccaaggcagc agactgttaa tcagacaaac agatctctga     4680



gaaggtgcat cagctgcttt gaaggctgaa gattgttttg tatgatactg cacagcatca     4740



ggcattttaa agcagatctt tactaaacag gttaatgagc taacaagcag gttctctcgt     4800



ctttgggctc tttcctttct gagttgcata ttctattttc ttgtccccaa gtagagacta     4860



gtactacaaa aagggaccac atttttcaag tatttctaag tataaaaaac aaaacaaaaa     4920



tctcttagga aatgtctaga cctccattct tggattccct ttctttcctt ttattttaaa     4980



aaagaacagt acccctcttt taagatgctg tcttacatta atgagcatct aatggaaaga     5040



aggtatgagt tgcactgagg attagaatag tggtgcgtta gtggcattat ctataaatac     5100



actcacctaa attgaaagct aagaaggaaa tgtaaatata atatatattt atatttgatg     5160



taatatggac atctgcagat tctaataaac aaggactatt gctgatagta ggctgtgaca     5220



tactgtcttg tgaaatggtt tccttgacaa aatttaagct gagcttaaaa gcaaaaaaca     5280



aaaagtacac agaaatattt attaaaatgt aatacagttt attgaacttt ctaggtatgg     5340



agtttgatgg acagggctgc ctttaatgag tgtgaaggtc actaagtcac ttagacatct     5400



caccgtggaa gtttgtgagc ctgcattagg agatagactg attaccatac atgacataaa     5460



aaggaacagt ggatagctca tactttatgg tggttcttct cctccgaaat aatatactgc     5520



agaaatccca gacagagctc cttacaaacc tttaattgta atatattttt gatgattatt     5580



cacattgaat gcacagacca agaattcagt gaatgtcatt ttttaaaaaa ctaatttgta     5640



ttgtctgctc tagtgataca agttttacta gtgataaact attttaatca accatactat     5700



tcttatggaa aaaaatatct attttggcag gtttctgtgc ctttatttcc ctcttctgaa     5760



aaaaagtctg tgttttcata gtttggtttg cattgtatat caataattaa tcaggaatgg     5820



gttttggtgc ctgaaaaatt ggccatggag gcacaccaaa gcttcaagca caagtcttgt     5880



acatgggcca tcactgtctg gtttcacttc gtgtgtttcc taaacacatt tagctgcttt     5940



tttaacaaac tcagccccat acttgagtcc cttgttgttg ggagcatttc caggcatctt     6000



ttaagggaac tgtgacaaac agcctcgggc agatgaacac ggaggctctc tgttgtctgt     6060



ctctgagatc tttgtgtctg ggaatgccta aagattttat ttttttttct ttgtttttat     6120



tttattttat tttatttttt tgagacagag tctcaccctg ttgcccaggc tggagtgcaa     6180



tggtgcgatc ttggctcact gcaacctcca cctcccagtt caagtgattc ccctgcctca     6240



gcctcgcgag tagctaggac tacaggcgca tgtcaccaag cccggctaat ttttgtattt     6300



ttagtagaaa cggggtttca ccatgttggc caggatgatc ctcaatctcc tgacctcgtg     6360



atccacccgc cttggcctcc caaagtgcgg gattacaagc gtgaaccacc ctgcccagcc     6420



agaaactaga ttttctttat gcctccaccc cttcttattc atttacttta caataccaaa     6480



ataacaaatt gcataggagt gtgggatgtg gtttctgcct tctagagaga gatcagaatt     6540



aaactagtac tatgaaatgt ccttttgaat gttaggtcaa gaaatccatg tacagagtcg     6600



tgcacttcat tggctgtaac tgtcaaactt gccttgtatt agaagttaaa tcccatcgta     6660



aatacatcac gaggccagct gtgtgatttc tgagacctag atgagagtcc atttacttca     6720



gcctttgatt cagtaaatgt taagcagcag aagacttcga atggttgaaa ttcattgtta     6780



caggatttaa ctcataaacc aatgagagat tttttttttc tctgcaatgg ttgctaagtc     6840



tattccatgt taacactgtg gaaataaata tgaagatgtg gacattgcaa aaaaaaaaaa     6900



aaaaaa                                                                6906





<210>  95

<211>  1487

<212>  PRT

<213>  Homo sapiens



<400>  95



Met Val Lys Leu Asp Ile His Thr Leu Ala His His Leu Lys Gln Glu 

1               5                   10                  15      





Arg Leu Tyr Val Asn Ser Glu Lys Gln Leu Ile Gln Arg Leu Asn Ala 

            20                  25                  30          





Asp Val Leu Lys Thr Ala Glu Lys Leu Tyr Arg Thr Ala Trp Ile Ala 

        35                  40                  45              





Lys Gln Gln Arg Ile Asn Leu Asp Arg Leu Ile Ile Thr Ser Ala Glu 

    50                  55                  60                  





Ala Ser Pro Ala Glu Cys Cys Gln His Ala Lys Ile Leu Glu Asp Thr 

65                  70                  75                  80  





Gln Phe Val Asp Gly Tyr Lys Gln Leu Gly Phe Gln Glu Thr Ala Tyr 

                85                  90                  95      





Gly Glu Phe Leu Ser Arg Leu Arg Glu Asn Pro Arg Leu Ile Ala Ser 

            100                 105                 110         





Ser Leu Val Ala Gly Glu Lys Leu Asn Gln Glu Asn Thr Gln Ser Val 

        115                 120                 125             





Ile Tyr Thr Val Phe Thr Ser Leu Tyr Gly Asn Cys Ile Met Gln Glu 

    130                 135                 140                 





Asp Glu Ser Tyr Leu Leu Gln Val Leu Arg Tyr Leu Ile Glu Phe Glu 

145                 150                 155                 160 





Leu Lys Glu Ser Asp Asn Pro Arg Arg Leu Leu Arg Arg Gly Thr Cys 

                165                 170                 175     





Ala Phe Ser Ile Leu Phe Lys Leu Phe Ser Glu Gly Leu Phe Ser Ala 

            180                 185                 190         





Lys Leu Phe Leu Thr Ala Thr Leu His Glu Pro Ile Met Gln Leu Leu 

        195                 200                 205             





Val Glu Asp Glu Asp His Leu Glu Thr Asp Pro Asn Lys Leu Ile Glu 

    210                 215                 220                 





Arg Phe Ser Pro Ser Gln Gln Glu Lys Leu Phe Gly Glu Lys Gly Ser 

225                 230                 235                 240 





Asp Arg Phe Arg Gln Lys Val Gln Glu Met Val Glu Ser Asn Glu Ala 

                245                 250                 255     





Lys Leu Val Ala Leu Val Asn Lys Phe Ile Gly Tyr Leu Lys Gln Asn 

            260                 265                 270         





Thr Tyr Cys Phe Pro His Ser Leu Arg Trp Ile Val Ser Gln Met Tyr 

        275                 280                 285             





Lys Thr Leu Ser Cys Val Asp Arg Leu Glu Val Gly Glu Val Arg Ala 

    290                 295                 300                 





Met Cys Thr Asp Leu Leu Leu Ala Cys Phe Ile Cys Pro Ala Val Val 

305                 310                 315                 320 





Asn Pro Glu Gln Tyr Gly Ile Ile Ser Asp Ala Pro Ile Asn Glu Val 

                325                 330                 335     





Ala Arg Phe Asn Leu Met Gln Val Gly Arg Leu Leu Gln Gln Leu Ala 

            340                 345                 350         





Met Thr Gly Ser Glu Glu Gly Asp Pro Arg Thr Lys Ser Ser Leu Gly 

        355                 360                 365             





Lys Phe Asp Lys Ser Cys Val Ala Ala Phe Leu Asp Val Val Ile Gly 

    370                 375                 380                 





Gly Arg Ala Val Glu Thr Pro Pro Leu Ser Ser Val Asn Leu Leu Glu 

385                 390                 395                 400 





Gly Leu Ser Arg Thr Val Val Tyr Ile Thr Tyr Ser Gln Leu Ile Thr 

                405                 410                 415     





Leu Val Asn Phe Met Lys Ser Val Met Ser Gly Asp Gln Leu Arg Glu 

            420                 425                 430         





Asp Arg Met Ala Leu Asp Asn Leu Leu Ala Asn Leu Pro Pro Ala Lys 

        435                 440                 445             





Pro Gly Lys Ser Ser Ser Leu Glu Met Thr Pro Tyr Asn Thr Pro Gln 

    450                 455                 460                 





Leu Ser Pro Ala Thr Thr Pro Ala Asn Lys Lys Asn Arg Leu Pro Ile 

465                 470                 475                 480 





Ala Thr Arg Ser Arg Ser Arg Thr Asn Met Leu Met Asp Leu His Met 

                485                 490                 495     





Asp His Glu Gly Ser Ser Gln Glu Thr Ile Gln Glu Val Gln Pro Glu 

            500                 505                 510         





Glu Val Leu Val Ile Ser Leu Gly Thr Gly Pro Gln Leu Thr Pro Gly 

        515                 520                 525             





Met Met Ser Glu Asn Glu Val Leu Asn Met Gln Leu Ser Asp Gly Gly 

    530                 535                 540                 





Gln Gly Asp Val Pro Val Asp Glu Asn Lys Leu His Gly Lys Pro Asp 

545                 550                 555                 560 





Lys Thr Leu Arg Phe Ser Leu Cys Ser Asp Asn Leu Glu Gly Ile Ser 

                565                 570                 575     





Glu Gly Pro Ser Asn Arg Ser Asn Ser Val Ser Ser Leu Asp Leu Glu 

            580                 585                 590         





Gly Glu Ser Val Ser Glu Leu Gly Ala Gly Pro Ser Gly Ser Asn Gly 

        595                 600                 605             





Val Glu Ala Leu Gln Leu Leu Glu His Glu Gln Ala Thr Thr Gln Asp 

    610                 615                 620                 





Asn Leu Asp Asp Lys Leu Arg Lys Phe Glu Ile Arg Asp Met Met Gly 

625                 630                 635                 640 





Leu Thr Asp Asp Arg Asp Ile Ser Glu Thr Val Ser Glu Thr Trp Ser 

                645                 650                 655     





Thr Asp Val Leu Gly Ser Asp Phe Asp Pro Asn Ile Asp Glu Asp Arg 

            660                 665                 670         





Leu Gln Glu Ile Ala Gly Ala Ala Ala Glu Asn Met Leu Gly Ser Leu 

        675                 680                 685             





Leu Cys Leu Pro Gly Ser Gly Ser Val Leu Leu Asp Pro Cys Thr Gly 

    690                 695                 700                 





Ser Thr Ile Ser Glu Thr Thr Ser Glu Ala Trp Ser Val Glu Val Leu 

705                 710                 715                 720 





Pro Ser Asp Ser Glu Ala Pro Asp Leu Lys Gln Glu Glu Arg Leu Gln 

                725                 730                 735     





Glu Leu Glu Ser Cys Ser Gly Leu Gly Ser Thr Ser Asp Asp Thr Asp 

            740                 745                 750         





Val Arg Glu Val Ser Ser Arg Pro Ser Thr Pro Gly Leu Ser Val Val 

        755                 760                 765             





Ser Gly Ile Ser Ala Thr Ser Glu Asp Ile Pro Asn Lys Ile Glu Asp 

    770                 775                 780                 





Leu Arg Ser Glu Cys Ser Ser Asp Phe Gly Gly Lys Asp Ser Val Thr 

785                 790                 795                 800 





Ser Pro Asp Met Asp Glu Ile Thr His Asp Phe Leu Tyr Ile Leu Gln 

                805                 810                 815     





Pro Lys Gln His Phe Gln His Ile Glu Ala Glu Ala Asp Met Arg Ile 

            820                 825                 830         





Gln Leu Ser Ser Ser Ala His Gln Leu Thr Ser Pro Pro Ser Gln Ser 

        835                 840                 845             





Glu Ser Leu Leu Ala Met Phe Asp Pro Leu Ser Ser His Glu Gly Ala 

    850                 855                 860                 





Ser Ala Val Val Arg Pro Lys Val His Tyr Ala Arg Pro Ser His Pro 

865                 870                 875                 880 





Pro Pro Asp Pro Pro Ile Leu Glu Gly Ala Val Gly Gly Asn Glu Ala 

                885                 890                 895     





Arg Leu Pro Asn Phe Gly Ser His Val Leu Thr Pro Ala Glu Met Glu 

            900                 905                 910         





Ala Phe Lys Gln Arg His Ser Tyr Pro Glu Arg Leu Val Arg Ser Arg 

        915                 920                 925             





Ser Ser Asp Ile Val Ser Ser Val Arg Arg Pro Met Ser Asp Pro Ser 

    930                 935                 940                 





Trp Asn Arg Arg Pro Gly Asn Glu Glu Arg Glu Leu Pro Pro Ala Ala 

945                 950                 955                 960 





Ala Ile Gly Ala Thr Ser Leu Val Ala Ala Pro His Ser Ser Ser Ser 

                965                 970                 975     





Ser Pro Ser Lys Asp Ser Ser Arg Gly Glu Thr Glu Glu Arg Lys Asp 

            980                 985                 990         





Ser Asp Asp Glu Lys Ser Asp Arg  Asn Arg Pro Trp Trp  Arg Lys Arg 

        995                 1000                 1005             





Phe Val  Ser Ala Met Pro Lys  Ala Pro Ile Pro Phe  Arg Lys Lys 

    1010                 1015                 1020             





Glu Lys  Gln Glu Lys Asp Lys  Asp Asp Leu Gly Pro  Asp Arg Phe 

    1025                 1030                 1035             





Ser Thr  Leu Thr Asp Asp Pro  Ser Pro Arg Leu Ser  Ala Gln Ala 

    1040                 1045                 1050             





Gln Val  Ala Glu Asp Ile Leu  Asp Lys Tyr Arg Asn  Ala Ile Lys 

    1055                 1060                 1065             





Arg Thr  Ser Pro Ser Asp Gly  Ala Met Ala Asn Tyr  Glu Ser Thr 

    1070                 1075                 1080             





Glu Val  Met Gly Asp Gly Glu  Ser Ala His Asp Ser  Pro Arg Asp 

    1085                 1090                 1095             





Glu Ala  Leu Gln Asn Ile Ser  Ala Asp Asp Leu Pro  Asp Ser Ala 

    1100                 1105                 1110             





Ser Gln  Ala Ala His Pro Gln  Asp Ser Ala Phe Ser  Tyr Arg Asp 

    1115                 1120                 1125             





Ala Lys  Lys Lys Leu Arg Leu  Ala Leu Cys Ser Ala  Asp Ser Val 

    1130                 1135                 1140             





Ala Phe  Pro Val Leu Thr His  Ser Thr Arg Asn Gly  Leu Pro Asp 

    1145                 1150                 1155             





His Thr  Asp Pro Glu Asp Asn  Glu Ile Val Cys Phe  Leu Lys Val 

    1160                 1165                 1170             





Gln Ile  Ala Glu Ala Ile Asn  Leu Gln Asp Lys Asn  Leu Met Ala 

    1175                 1180                 1185             





Gln Leu  Gln Glu Thr Met Arg  Cys Val Cys Arg Phe  Asp Asn Arg 

    1190                 1195                 1200             





Thr Cys  Arg Lys Leu Leu Ala  Ser Ile Ala Glu Asp  Tyr Arg Lys 

    1205                 1210                 1215             





Arg Ala  Pro Tyr Ile Ala Tyr  Leu Thr Arg Cys Arg  Gln Gly Leu 

    1220                 1225                 1230             





Gln Thr  Thr Gln Ala His Leu  Glu Arg Leu Leu Gln  Arg Val Leu 

    1235                 1240                 1245             





Arg Asp  Lys Glu Val Ala Asn  Arg Tyr Phe Thr Thr  Val Cys Val 

    1250                 1255                 1260             





Arg Leu  Leu Leu Glu Ser Lys  Glu Lys Lys Ile Arg  Glu Phe Ile 

    1265                 1270                 1275             





Gln Asp  Phe Gln Lys Leu Thr  Ala Ala Asp Asp Lys  Thr Ala Gln 

    1280                 1285                 1290             





Val Glu  Asp Phe Leu Gln Phe  Leu Tyr Gly Ala Met  Ala Gln Asp 

    1295                 1300                 1305             





Val Ile  Trp Gln Asn Ala Ser  Glu Glu Gln Leu Gln  Asp Ala Gln 

    1310                 1315                 1320             





Leu Ala  Ile Glu Arg Ser Val  Met Asn Arg Ile Phe  Lys Leu Ala 

    1325                 1330                 1335             





Phe Tyr  Pro Asn Gln Asp Gly  Asp Ile Leu Arg Asp  Gln Val Leu 

    1340                 1345                 1350             





His Glu  His Ile Gln Arg Leu  Ser Lys Val Val Thr  Ala Asn His 

    1355                 1360                 1365             





Arg Ala  Leu Gln Ile Pro Glu  Val Tyr Leu Arg Glu  Ala Pro Trp 

    1370                 1375                 1380             





Pro Ser  Ala Gln Ser Glu Ile  Arg Thr Ile Ser Ala  Tyr Lys Thr 

    1385                 1390                 1395             





Pro Arg  Asp Lys Val Gln Cys  Ile Leu Arg Met Cys  Ser Thr Ile 

    1400                 1405                 1410             





Met Asn  Leu Leu Ser Leu Ala  Asn Glu Asp Ser Val  Pro Gly Ala 

    1415                 1420                 1425             





Asp Asp  Phe Val Pro Val Leu  Val Phe Val Leu Ile  Lys Ala Asn 

    1430                 1435                 1440             





Pro Pro  Cys Leu Leu Ser Thr  Val Gln Tyr Ile Ser  Ser Phe Tyr 

    1445                 1450                 1455             





Ala Ser  Cys Leu Ser Gly Glu  Glu Ser Tyr Trp Trp  Met Gln Phe 

    1460                 1465                 1470             





Thr Ala  Ala Val Glu Phe Ile  Lys Thr Ile Asp Asp  Arg Lys 

    1475                 1480                 1485         





<210>  96

<211>  1975

<212>  DNA

<213>  Homo sapiens



<400>  96

ggagcaagat ggcggcgcga gtgctgcgcg cccgcggagc ggcctgggcc ggcggcctcc       60



tgcagcgggc ggccccctgc agcctcctgc ccaggctccg gacatggaca tcttccagca      120



acagatctcg agaagacagc tggctaaaat ccttatttgt ccggaaagtt gatccaagaa      180



aagatgccca ctccaatctc ctagccaaaa aggaaacaag caatctatac aaattacagt      240



ttcacaatgt taaaccggaa tgcctagaag catacaacaa aatttgtcaa gaggtgttgc      300



caaagattca cgaagataaa cactaccctt gtactttggt ggggacttgg aacacgtggt      360



atggcgagca ggaccaagct gtccacctct ggaggtatga aggaggctat ccagccctca      420



cagaagtcat gaataaactc agagaaaata aggaattttt ggaatttcgt aaggcaagaa      480



gtgacatgct tctctccagg aagaatcagc tcctgttgga gttcagtttc tggaatgagc      540



ctgtgccaag atccggacct aatatatatg aactcaggtc ttaccaactc cgaccaggaa      600



ccatgattga atggggcaat tactgggctc gtgcaatccg cttcagacag gatggtaacg      660



aagccgtcgg aggattcttc tctcagattg ggcagctgta catggtgcac catctttggg      720



cttacaggga tcttcagacc agggaagaca tacggaatgc agcatggcac aaacatggct      780



gggaggaatt ggtatattac acagttccac ttattcagga aatggaatcc agaatcatga      840



tcccactgaa gacctcgccc ctccagtaaa gctgtagagt ttctatgtgc ctacatacat      900



ttctgtgaca agtatttgtc gtaaattaat tttaattgtg tatcaagtga aaaagaaaca      960



ctgaggtttt aagctgctgt atatagcttg tgagaaacct cttttcttta aaatttacat     1020



aatcacaaga aaggaaagaa ttacagttgg actgattgtg acagtgcctt gtcgtcctct     1080



ttgaaacacc ccgtgttgtc cagtatacct tataacactt agccacttct ccccaccctc     1140



cagaaggggt ccacgttgaa ttctgaatca tcttgaaaat aagattccaa ccacaaaaaa     1200



aatttagcca tttctttact aaaaaaaacc aaaaaacaaa tctgttttat aatcacagat     1260



ttttagacaa atttcttgta tcaggaagaa atacaaattt tgtcatgttt ctcaagcagt     1320



ttttctgagt agtttctgag gaggaacaaa ttacaagtgt acccaataac tgaaaatgtt     1380



ttaactcact ctcatttgta agcagtccac atagtagaca atgggttttc caagctgggc     1440



aaggtacatt taatcagtaa atcagtttca catcatgtat tgtgatgttt caatgtgaga     1500



cacaaaaaca atggcttgaa acttgtgtat catatgtgat tttgaaatga acaccttgaa     1560



tagcactaat ttttatttgt ggtatttttc tataacaaaa caagtagctc taggaaaaga     1620



ggttttattt tgtaaacgat catttgtgac ctcagacact ctctggctaa tattttaata     1680



agctcacagc agataattct gagatcatgg gtgaggggtg gtgcatgttg agatttaaat     1740



tggcataaag ctgcatactt tttgtctagc tgtttgattt cattttttaa tatagtatgc     1800



caattttgtg actgttacca tgtgaaagtc ctgttgaaat gaacaattgt ctgccccaca     1860



atcaagaatg tatgtgtaaa gtgtgaataa atctcatatc aaatgtcaaa cttttacatg     1920



tgaatgattt tctcaaagaa catagaaaag gcaataaaat cctcttaatt tccac          1975





<210>  97

<211>  286

<212>  PRT

<213>  Homo sapiens



<400>  97



Met Ala Ala Arg Val Leu Arg Ala Arg Gly Ala Ala Trp Ala Gly Gly 

1               5                   10                  15      





Leu Leu Gln Arg Ala Ala Pro Cys Ser Leu Leu Pro Arg Leu Arg Thr 

            20                  25                  30          





Trp Thr Ser Ser Ser Asn Arg Ser Arg Glu Asp Ser Trp Leu Lys Ser 

        35                  40                  45              





Leu Phe Val Arg Lys Val Asp Pro Arg Lys Asp Ala His Ser Asn Leu 

    50                  55                  60                  





Leu Ala Lys Lys Glu Thr Ser Asn Leu Tyr Lys Leu Gln Phe His Asn 

65                  70                  75                  80  





Val Lys Pro Glu Cys Leu Glu Ala Tyr Asn Lys Ile Cys Gln Glu Val 

                85                  90                  95      





Leu Pro Lys Ile His Glu Asp Lys His Tyr Pro Cys Thr Leu Val Gly 

            100                 105                 110         





Thr Trp Asn Thr Trp Tyr Gly Glu Gln Asp Gln Ala Val His Leu Trp 

        115                 120                 125             





Arg Tyr Glu Gly Gly Tyr Pro Ala Leu Thr Glu Val Met Asn Lys Leu 

    130                 135                 140                 





Arg Glu Asn Lys Glu Phe Leu Glu Phe Arg Lys Ala Arg Ser Asp Met 

145                 150                 155                 160 





Leu Leu Ser Arg Lys Asn Gln Leu Leu Leu Glu Phe Ser Phe Trp Asn 

                165                 170                 175     





Glu Pro Val Pro Arg Ser Gly Pro Asn Ile Tyr Glu Leu Arg Ser Tyr 

            180                 185                 190         





Gln Leu Arg Pro Gly Thr Met Ile Glu Trp Gly Asn Tyr Trp Ala Arg 

        195                 200                 205             





Ala Ile Arg Phe Arg Gln Asp Gly Asn Glu Ala Val Gly Gly Phe Phe 

    210                 215                 220                 





Ser Gln Ile Gly Gln Leu Tyr Met Val His His Leu Trp Ala Tyr Arg 

225                 230                 235                 240 





Asp Leu Gln Thr Arg Glu Asp Ile Arg Asn Ala Ala Trp His Lys His 

                245                 250                 255     





Gly Trp Glu Glu Leu Val Tyr Tyr Thr Val Pro Leu Ile Gln Glu Met 

            260                 265                 270         





Glu Ser Arg Ile Met Ile Pro Leu Lys Thr Ser Pro Leu Gln 

        275                 280                 285     





<210>  98

<211>  3127

<212>  DNA

<213>  Homo sapiens



<400>  98

ggttgcccat gcggccctag ggctgggagc gcggcgccgc tctccgctgc gggggaggcc       60



atggcggaac cttcccaggc cccgaccccg gccccggctg cgcagccccg gccccttcag      120



tccccagccc ctgccccaac tccgactcct gcacccagcc cggcttcagc cccgattccg      180



actcccaccc cggcaccagc ccctgcccca gctgcagccc cagccggcag cacagggact      240



ggggggcccg gggtaggaag tgggggggcc gggagcgggg gggatccggc tcgacctggc      300



ctgagccagc agcagcgcgc cagtcagagg aaggcgcaag tccgggggct gccgcgcgcc      360



aagaagcttg agaagctagg ggtcttctcg gcttgcaagg ccaatgaaac ctgtaagtgt      420



aatggctgga aaaaccccaa gccccccact gcaccccgca tggatctgca gcagccagct      480



gccaacctga gtgagctgtg ccgcagttgt gagcacccct tggctgacca cgtatcccac      540



ttggagaatg tgtcagagga tgagataaac cgactgctgg ggatggtggt ggatgtggag      600



aatctcttca tgtctgttca caaggaagag gacacagaca ccaagcaggt ctatttctac      660



ctcttcaagc tactgcggaa atgcatcctg cagatgaccc ggcctgtggt ggaggggtcc      720



ctgggcagcc ctccatttga gaaacctaat attgagcagg gtgtgctgaa ctttgtgcag      780



tacaagttta gtcacctggc tccccgggag cggcagacga tgttcgagct ctcaaagatg      840



ttcttgctct gccttaacta ctggaagctt gagacacctg cccagtttcg gcagaggtct      900



caggctgagg acgtggctac ctacaaggtc aattacacca gatggctctg ttactgccac      960



gtgccccaga gctgtgatag cctcccccgc tacgaaacca ctcatgtctt tgggcgaagc     1020



cttctccggt ccattttcac cgttacccgc cggcagctgc tggaaaagtt ccgagtggag     1080



aaggacaaat tggtgcccga gaagaggacc ctcatcctca ctcacttccc caaattcctg     1140



tccatgctgg aggaggagat ctatggggca aactctccaa tctgggagtc aggcttcacc     1200



atgccaccct cagaggggac acagctggtt ccccggccag cttcagtcag tgcagcggtt     1260



gttcccagca cccccatctt cagccccagc atgggtgggg gcagcaacag ctccctgagt     1320



ctggattctg caggggccga gcctatgcca ggcgagaaga ggacgctccc agagaacctg     1380



accctggagg atgccaagcg gctccgtgtg atgggtgaca tccccatgga gctggtcaat     1440



gaggtcatgc tgaccatcac tgaccctgct gccatgctgg ggcctgagac gagcctgctt     1500



tcggccaatg cggcccggga tgagacagcc cgcctggagg agcgccgcgg catcatcgag     1560



ttccatgtca tcggcaactc actgacgccc aaggccaacc ggcgggtgtt gctgtggctc     1620



gtggggctgc agaatgtctt ttcccaccag ctgccgcgca tgcctaagga gtatatcgcc     1680



cgcctcgtct ttgacccgaa gcacaagact ctggccttga tcaaggatgg gcgggtcatc     1740



ggtggcatct gcttccgcat gtttcccacc cagggcttca cggagattgt cttctgtgct     1800



gtcacctcga atgagcaggt caagggttat gggacccacc tgatgaacca cctgaaggag     1860



tatcacatca agcacaacat tctctacttc ctcacctacg ccgacgagta cgccatcggc     1920



tacttcaaaa agcagggttt ctccaaggac atcaaggtgc ccaagagccg ctacctgggc     1980



tacatcaagg actacgaggg agcgacgctg atggagtgtg agctgaatcc ccgcatcccc     2040



tacacggagc tgtcccacat catcaagaag cagaaagaga tcatcaagaa gctgattgag     2100



cgcaaacagg cccagatccg caaggtctac ccggggctca gctgcttcaa ggagggcgtg     2160



aggcagatcc ctgtggagag cgttcctggc attcgagaga caggctggaa gccattgggg     2220



aaggagaagg ggaaggagct gaaggacccc gaccagctct acacaaccct caaaaacctg     2280



ctggcccaaa tcaagtctca ccccagtgcc tggcccttca tggagcctgt gaagaagtcg     2340



gaggcccctg actactacga ggtcatccgc ttccccattg acctgaagac catgactgag     2400



cggctgcgaa gccgctacta cgtgacccgg aagctctttg tggccgacct gcagcgggtc     2460



atcgccaact gtcgcgagta caaccccccg gacagcgagt actgccgctg tgccagcgcc     2520



ctggagaagt tcttctactt caagctcaag gagggaggcc tcattgacaa gtaggcccat     2580



ctttgggccg cagccctgac ctggaatgtc tccacctcgg attctgatct gatccttagg     2640



gggtgccctg gccccacgga cccgactcag cttgagacac tccagccaag ggtcctccgg     2700



acccgatcct gcagctcttt ctggaccttc aggcaccccc aagcgtgcag ctctgtccca     2760



gccttcactg tgtgtgagag gtctcctggg ttggggccca gcccctctag agtagctggt     2820



ggccagggat gaaccttgcc cagccgtggt ggcccccagg cctggtcccc aagagctttg     2880



gaggcttgga ttcctgggcc tggcccaggt ggctgtttcc ctgaggacca gaactgctca     2940



ttttagcttg agtgatggct tcaggggttg gaagttcagc ccaaactgaa gggggccatg     3000



ccttgtccag cactgttctg tcagtctccc ccaggggtgg ggggtatggg gaccattcat     3060



tccctggcat taatccctta gagggaataa taaagctttt tatttctctg tgaaaaaaaa     3120



aaaaaaa                                                               3127





<210>  99

<211>  837

<212>  PRT

<213>  Homo sapiens



<400>  99



Met Ala Glu Pro Ser Gln Ala Pro Thr Pro Ala Pro Ala Ala Gln Pro 

1               5                   10                  15      





Arg Pro Leu Gln Ser Pro Ala Pro Ala Pro Thr Pro Thr Pro Ala Pro 

            20                  25                  30          





Ser Pro Ala Ser Ala Pro Ile Pro Thr Pro Thr Pro Ala Pro Ala Pro 

        35                  40                  45              





Ala Pro Ala Ala Ala Pro Ala Gly Ser Thr Gly Thr Gly Gly Pro Gly 

    50                  55                  60                  





Val Gly Ser Gly Gly Ala Gly Ser Gly Gly Asp Pro Ala Arg Pro Gly 

65                  70                  75                  80  





Leu Ser Gln Gln Gln Arg Ala Ser Gln Arg Lys Ala Gln Val Arg Gly 

                85                  90                  95      





Leu Pro Arg Ala Lys Lys Leu Glu Lys Leu Gly Val Phe Ser Ala Cys 

            100                 105                 110         





Lys Ala Asn Glu Thr Cys Lys Cys Asn Gly Trp Lys Asn Pro Lys Pro 

        115                 120                 125             





Pro Thr Ala Pro Arg Met Asp Leu Gln Gln Pro Ala Ala Asn Leu Ser 

    130                 135                 140                 





Glu Leu Cys Arg Ser Cys Glu His Pro Leu Ala Asp His Val Ser His 

145                 150                 155                 160 





Leu Glu Asn Val Ser Glu Asp Glu Ile Asn Arg Leu Leu Gly Met Val 

                165                 170                 175     





Val Asp Val Glu Asn Leu Phe Met Ser Val His Lys Glu Glu Asp Thr 

            180                 185                 190         





Asp Thr Lys Gln Val Tyr Phe Tyr Leu Phe Lys Leu Leu Arg Lys Cys 

        195                 200                 205             





Ile Leu Gln Met Thr Arg Pro Val Val Glu Gly Ser Leu Gly Ser Pro 

    210                 215                 220                 





Pro Phe Glu Lys Pro Asn Ile Glu Gln Gly Val Leu Asn Phe Val Gln 

225                 230                 235                 240 





Tyr Lys Phe Ser His Leu Ala Pro Arg Glu Arg Gln Thr Met Phe Glu 

                245                 250                 255     





Leu Ser Lys Met Phe Leu Leu Cys Leu Asn Tyr Trp Lys Leu Glu Thr 

            260                 265                 270         





Pro Ala Gln Phe Arg Gln Arg Ser Gln Ala Glu Asp Val Ala Thr Tyr 

        275                 280                 285             





Lys Val Asn Tyr Thr Arg Trp Leu Cys Tyr Cys His Val Pro Gln Ser 

    290                 295                 300                 





Cys Asp Ser Leu Pro Arg Tyr Glu Thr Thr His Val Phe Gly Arg Ser 

305                 310                 315                 320 





Leu Leu Arg Ser Ile Phe Thr Val Thr Arg Arg Gln Leu Leu Glu Lys 

                325                 330                 335     





Phe Arg Val Glu Lys Asp Lys Leu Val Pro Glu Lys Arg Thr Leu Ile 

            340                 345                 350         





Leu Thr His Phe Pro Lys Phe Leu Ser Met Leu Glu Glu Glu Ile Tyr 

        355                 360                 365             





Gly Ala Asn Ser Pro Ile Trp Glu Ser Gly Phe Thr Met Pro Pro Ser 

    370                 375                 380                 





Glu Gly Thr Gln Leu Val Pro Arg Pro Ala Ser Val Ser Ala Ala Val 

385                 390                 395                 400 





Val Pro Ser Thr Pro Ile Phe Ser Pro Ser Met Gly Gly Gly Ser Asn 

                405                 410                 415     





Ser Ser Leu Ser Leu Asp Ser Ala Gly Ala Glu Pro Met Pro Gly Glu 

            420                 425                 430         





Lys Arg Thr Leu Pro Glu Asn Leu Thr Leu Glu Asp Ala Lys Arg Leu 

        435                 440                 445             





Arg Val Met Gly Asp Ile Pro Met Glu Leu Val Asn Glu Val Met Leu 

    450                 455                 460                 





Thr Ile Thr Asp Pro Ala Ala Met Leu Gly Pro Glu Thr Ser Leu Leu 

465                 470                 475                 480 





Ser Ala Asn Ala Ala Arg Asp Glu Thr Ala Arg Leu Glu Glu Arg Arg 

                485                 490                 495     





Gly Ile Ile Glu Phe His Val Ile Gly Asn Ser Leu Thr Pro Lys Ala 

            500                 505                 510         





Asn Arg Arg Val Leu Leu Trp Leu Val Gly Leu Gln Asn Val Phe Ser 

        515                 520                 525             





His Gln Leu Pro Arg Met Pro Lys Glu Tyr Ile Ala Arg Leu Val Phe 

    530                 535                 540                 





Asp Pro Lys His Lys Thr Leu Ala Leu Ile Lys Asp Gly Arg Val Ile 

545                 550                 555                 560 





Gly Gly Ile Cys Phe Arg Met Phe Pro Thr Gln Gly Phe Thr Glu Ile 

                565                 570                 575     





Val Phe Cys Ala Val Thr Ser Asn Glu Gln Val Lys Gly Tyr Gly Thr 

            580                 585                 590         





His Leu Met Asn His Leu Lys Glu Tyr His Ile Lys His Asn Ile Leu 

        595                 600                 605             





Tyr Phe Leu Thr Tyr Ala Asp Glu Tyr Ala Ile Gly Tyr Phe Lys Lys 

    610                 615                 620                 





Gln Gly Phe Ser Lys Asp Ile Lys Val Pro Lys Ser Arg Tyr Leu Gly 

625                 630                 635                 640 





Tyr Ile Lys Asp Tyr Glu Gly Ala Thr Leu Met Glu Cys Glu Leu Asn 

                645                 650                 655     





Pro Arg Ile Pro Tyr Thr Glu Leu Ser His Ile Ile Lys Lys Gln Lys 

            660                 665                 670         





Glu Ile Ile Lys Lys Leu Ile Glu Arg Lys Gln Ala Gln Ile Arg Lys 

        675                 680                 685             





Val Tyr Pro Gly Leu Ser Cys Phe Lys Glu Gly Val Arg Gln Ile Pro 

    690                 695                 700                 





Val Glu Ser Val Pro Gly Ile Arg Glu Thr Gly Trp Lys Pro Leu Gly 

705                 710                 715                 720 





Lys Glu Lys Gly Lys Glu Leu Lys Asp Pro Asp Gln Leu Tyr Thr Thr 

                725                 730                 735     





Leu Lys Asn Leu Leu Ala Gln Ile Lys Ser His Pro Ser Ala Trp Pro 

            740                 745                 750         





Phe Met Glu Pro Val Lys Lys Ser Glu Ala Pro Asp Tyr Tyr Glu Val 

        755                 760                 765             





Ile Arg Phe Pro Ile Asp Leu Lys Thr Met Thr Glu Arg Leu Arg Ser 

    770                 775                 780                 





Arg Tyr Tyr Val Thr Arg Lys Leu Phe Val Ala Asp Leu Gln Arg Val 

785                 790                 795                 800 





Ile Ala Asn Cys Arg Glu Tyr Asn Pro Pro Asp Ser Glu Tyr Cys Arg 

                805                 810                 815     





Cys Ala Ser Ala Leu Glu Lys Phe Phe Tyr Phe Lys Leu Lys Glu Gly 

            820                 825                 830         





Gly Leu Ile Asp Lys 

        835         





<210>  100

<211>  723

<212>  DNA

<213>  Homo sapiens



<400>  100

gtcggcgcgg gaggctcaga tggctggagg cggcgggcac gcacactgcg gggctccgag       60



gggcacaggt ccaggctcct gcgtgaagtg atgctcctct ttgccttact cctagccatg      120



gagctcccat tggtggcagc cagtgccacc atgcgcgctc agtggactta cagtttgaga      180



tgccatgact gtgcggtcat aaatgacttc aactgtccca acattagagt atgtccgtat      240



catattaggc gctgtatgac aatctccatt cgcataaatt ctcgtgaact acttgtttat      300



aagaactgta caaacaactg cacatttgta tatgcagctg aacagcctcc tgaagcccca      360



ggaaaaatct tcaaaactaa tagcttctac tgggtttgtt gttgtaatag catggtttgc      420



aatgcaggag gacctactaa tcttgaaagg gacatgttac ccgatgaagt aactgaggag      480



gagcttccag aaggaactgt gaggctgggg gtatcaaaac tgttgctgag ttttgcctct      540



atcatagtca gcaatatatt gccatgagga ccccaccttg gagggtctga ccatcttcac      600



ctgttccgca gagaaatgtt gctctccatt attcccttct aagccagaga cccttatcca      660



ctgctcctct aggtggccca tttatggttt gttgtaagag aaaaattaaa aaaatattgt      720



tta                                                                    723





<210>  101

<211>  158

<212>  PRT

<213>  Homo sapiens



<400>  101



Met Leu Leu Phe Ala Leu Leu Leu Ala Met Glu Leu Pro Leu Val Ala 

1               5                   10                  15      





Ala Ser Ala Thr Met Arg Ala Gln Trp Thr Tyr Ser Leu Arg Cys His 

            20                  25                  30          





Asp Cys Ala Val Ile Asn Asp Phe Asn Cys Pro Asn Ile Arg Val Cys 

        35                  40                  45              





Pro Tyr His Ile Arg Arg Cys Met Thr Ile Ser Ile Arg Ile Asn Ser 

    50                  55                  60                  





Arg Glu Leu Leu Val Tyr Lys Asn Cys Thr Asn Asn Cys Thr Phe Val 

65                  70                  75                  80  





Tyr Ala Ala Glu Gln Pro Pro Glu Ala Pro Gly Lys Ile Phe Lys Thr 

                85                  90                  95      





Asn Ser Phe Tyr Trp Val Cys Cys Cys Asn Ser Met Val Cys Asn Ala 

            100                 105                 110         





Gly Gly Pro Thr Asn Leu Glu Arg Asp Met Leu Pro Asp Glu Val Thr 

        115                 120                 125             





Glu Glu Glu Leu Pro Glu Gly Thr Val Arg Leu Gly Val Ser Lys Leu 

    130                 135                 140                 





Leu Leu Ser Phe Ala Ser Ile Ile Val Ser Asn Ile Leu Pro 

145                 150                 155             





<210>  102

<211>  2676

<212>  DNA

<213>  Homo sapiens



<400>  102

atattggaaa ggcgccgccg ccgcctccgc cttggagctc ggggtgtttc ggggactgcg       60



gccacaggca ggaaggcgct cctctcctgc cccgccgacg cccggccagc ccgcttcgcc      120



ctgacctgtt tcctcatgac tgcccccggc cctgctgccg acggacgtcg ccccggcgtc      180



cggatttaac acggaaaccc ggatcggagg ccgcgcgggg aggaggaggg cgacccggtc      240



ggtcctgcga ccctctcggc ccggctcggc gcctcggcgg gagccatgac ctcgctgacc      300



cagcgcagct ccggcctggt gcagcggcgc accgaggcct cccgcaacgc cgccgacaag      360



gagcgggcgg cgggcggcgg cgccggcagc agcgaggacg acgcgcagag ccgccgcgac      420



gagcaggacg acgacgacaa gggcgactcc aaggaaacgc ggctgaccct gatggaggaa      480



gtgctcctgc tgggcctcaa ggaccgcgag ggttacacat cattttggaa tgactgtata      540



tcatctggat tacgtggctg tatgttaatt gaattagcat tgagaggaag gttacaacta      600



gaggcttgtg gaatgagacg taaaagtcta ttaacaagaa aggtaatctg taagtcagat      660



gctccaacag gggatgttct tcttgatgaa gctctgaagc atgttaagga aactcagcct      720



ccagaaacgg tccagaactg gattgaatta cttagtggtg agacatggaa tccattaaaa      780



ttgcattatc agttaagaaa tgtacgggaa cgattagcta aaaacctggt ggaaaagggt      840



gtattgacaa cagagaaaca gaacttccta ctttttgaca tgacaacaca tcccctcacc      900



aataacaaca ttaagcagcg cctcatcaag aaagtacagg aagccgttct tgacaaatgg      960



gtgaatgacc ctcaccgcat ggacaggcgc ttgctggccc tcatttacct ggctcatgcc     1020



tcggacgtcc tggagaatgc ttttgctcct cttctggacg agcagtatga tttggctacc     1080



aagagagtgc ggcagcttct cgacttagac cctgaagtgg aatgtctgaa ggccaacacc     1140



aatgaggttc tgtgggcggt ggtggcggcg ttcaccaagt aactctgctc ggggtgaacc     1200



attctccttt ctctcaagta aaccagtagt ttttcttctg ttgacttctg gttttctgta     1260



atttgtactt tcccacacta taattggctt ctgttttaca aaatggtggg tggctttttc     1320



ttttttgtac gtgtacagga ttctgctggt acgagaggcc ttcctctttc tgtttttaaa     1380



aaaagtttta ctgccatatt ggcattccat tccctgttgc catcctcact gttacctgtt     1440



ttgggtttct ggtctacttt gactttcaaa gtacctccag cctcctcata cgcacagctt     1500



ttggatgacc tcagcttgag tttctccata tgtgcatgta catctagcat tctgcctaca     1560



gttcagacag aagtcacaaa aaggccttca actcaccaaa ggtaaatatc tgtatctatt     1620



aggacatttt ttacatagac ttcagttgag atgtatactt agcaaaatta tttttaaatt     1680



gaaacagcac agtaaatact taatataaaa tgtcccttgg attttgcttc ccatgtaaat     1740



ctattgtatt attacacttg ttataatttt aactataaag gtccaattgt ttcacagagc     1800



cagtttggga tgggctgcat tccatttatg ctgtatatag tttgaattat atataaatta     1860



ccccttcttc tggccacccc tgctcccatc ttagtatttt gcaagatcta atcagttgta     1920



cacctggtgc ccctcgcttg cttcaatcat ggttatttga tggcaaaatc gacctcttgt     1980



cgctgaagga gagagaaaag atgtgtgtct gattggtcct gggatttttt gagctgtgcc     2040



atttatggta ctctttgcct atgcatcccc ttgttagatt ttttttaaat tttatcttac     2100



tgtttttata atttctattg ggaagaggct tgtgaccagt accaatcttg agtttctttt     2160



tctgtccaca agtaaattaa tatctgctct gaaatgtcat ttatctactc acacattctt     2220



ggggaaaaaa atcaaatgtc agtcctagca gatgttgcat gtaaattggt agcaagtaat     2280



gattacaacc cagaggatta agaattttgt aacagaaagc tctatgtttt aattttttat     2340



atacaattag gataattagc attgtcagac tataaacctt tgctttttaa agtttatttt     2400



tactatttct ttatcacttt attgtatcat caccattggt ttcataatgt aaatactata     2460



tgttgaacaa attaaatgtc aaaatttttt attaccatag tccatgttaa tagtggggct     2520



ttcaggtgtt tagagatttt ttttgttgtt gttaacattc attgcaaaag tactagatgg     2580



tgtataactc tagagttgaa ttttaaggga ttccctaata tgtatactat ctttttatct     2640



gaagtaataa ataaacaatg atcttgaaag tgcctg                               2676





<210>  103

<211>  298

<212>  PRT

<213>  Homo sapiens



<400>  103



Met Thr Ser Leu Thr Gln Arg Ser Ser Gly Leu Val Gln Arg Arg Thr 

1               5                   10                  15      





Glu Ala Ser Arg Asn Ala Ala Asp Lys Glu Arg Ala Ala Gly Gly Gly 

            20                  25                  30          





Ala Gly Ser Ser Glu Asp Asp Ala Gln Ser Arg Arg Asp Glu Gln Asp 

        35                  40                  45              





Asp Asp Asp Lys Gly Asp Ser Lys Glu Thr Arg Leu Thr Leu Met Glu 

    50                  55                  60                  





Glu Val Leu Leu Leu Gly Leu Lys Asp Arg Glu Gly Tyr Thr Ser Phe 

65                  70                  75                  80  





Trp Asn Asp Cys Ile Ser Ser Gly Leu Arg Gly Cys Met Leu Ile Glu 

                85                  90                  95      





Leu Ala Leu Arg Gly Arg Leu Gln Leu Glu Ala Cys Gly Met Arg Arg 

            100                 105                 110         





Lys Ser Leu Leu Thr Arg Lys Val Ile Cys Lys Ser Asp Ala Pro Thr 

        115                 120                 125             





Gly Asp Val Leu Leu Asp Glu Ala Leu Lys His Val Lys Glu Thr Gln 

    130                 135                 140                 





Pro Pro Glu Thr Val Gln Asn Trp Ile Glu Leu Leu Ser Gly Glu Thr 

145                 150                 155                 160 





Trp Asn Pro Leu Lys Leu His Tyr Gln Leu Arg Asn Val Arg Glu Arg 

                165                 170                 175     





Leu Ala Lys Asn Leu Val Glu Lys Gly Val Leu Thr Thr Glu Lys Gln 

            180                 185                 190         





Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Leu Thr Asn Asn Asn 

        195                 200                 205             





Ile Lys Gln Arg Leu Ile Lys Lys Val Gln Glu Ala Val Leu Asp Lys 

    210                 215                 220                 





Trp Val Asn Asp Pro His Arg Met Asp Arg Arg Leu Leu Ala Leu Ile 

225                 230                 235                 240 





Tyr Leu Ala His Ala Ser Asp Val Leu Glu Asn Ala Phe Ala Pro Leu 

                245                 250                 255     





Leu Asp Glu Gln Tyr Asp Leu Ala Thr Lys Arg Val Arg Gln Leu Leu 

            260                 265                 270         





Asp Leu Asp Pro Glu Val Glu Cys Leu Lys Ala Asn Thr Asn Glu Val 

        275                 280                 285             





Leu Trp Ala Val Val Ala Ala Phe Thr Lys 

    290                 295             





<210>  104

<211>  2220

<212>  DNA

<213>  Homo sapiens



<400>  104

aaccggaagg ggggctgtga ggacgtgttc cgaggaagcc agagccggag ccgtggcctg       60



cggggccggc gacatggatc ccctgttcca gcaaacgcac aagcaggtcc acgagatcca      120



gtcttgcatg ggacgcctgg agacggcaga caagcagtct gtgcacatag tagaaaacga      180



aatccaagca agcatagacc agatattcag ccgtctagaa cgtctggaga ttttgtccag      240



caaggagccc cctaacaaaa ggcaaaatgc cagacttcgg gttgaccagt taaagtatga      300



tgtccagcac ctgcagactg cgctcagaaa cttccagcat cggcgccatg caagggagca      360



gcaggagaga cagcgagaag agcttctgtc tcgaaccttc accactaacg actctgacac      420



caccatacca atggacgaat cactgcagtt taactcctcc ctccagaaag ttcacaacgg      480



catggatgac ctcattttag atgggcacaa tattttagat ggactgagga cccagagact      540



gaccttgaag gtggggtccc tgctggggga cagagagaag gcctcttgtt ttagcctcat      600



ccaacagttt agtaactgtg tttatatttt gattacgtgt cctcaaattg tgatattttg      660



atgacaagac agagcccttg agtttgggat cctttctgtt ggagttgagt tattgtgagc      720



ctgaaagtac ccagttcctt tgccagtgct tgaaacaaac catgaagtgg cctctcttag      780



gatccaggtc ttttcccatt tactgaactt atcatgaaag tgagtgctac tacgaggggt      840



ccaatcacag gctgagaaat tgtgttacag aatctactct tggaagaatg aagacgtggc      900



tgtcctttgg tacctcgctt taaggtggct ttcccttagg acccctactg tggactgcct      960



tataactaaa accttttgta ttttagtaac tgaatcccca ctgtgcagtg ttagggctgc     1020



ctggttgttt gcagtagatt agagctttag aagcttctag agcttctaaa gcccgtgctg     1080



gtgatcccag cgactcttca ctccctagcc ttaggtattc ctagaagccc tgaccagttg     1140



gcactgctga gactccagcc cctgggagtg gtttacagaa acattacaca gactctgatg     1200



tcagtcatga tgtttcagcc tctgcccttt tcctgtatca accctgatgg ataatagggc     1260



gtgggttctg tctgttatca gggtgtggtc ccctgtgaat gaagcactcc cagccactga     1320



gctgtgagaa acagtcactc ggaagtgtga gctttatctt agtttttgtt ggatcatgtt     1380



gagtctgtca gctccacagg acttcagtac gtttctgaac agtccctgcc atctctacgg     1440



gggagagggt caggcaagct gcaagtgaca ctcacctcct gctgacagtt gcagtgtctc     1500



agatggcctg gaagggtggt ctccagcagc ctgctgggcg ctcccctttc atgagagcca     1560



cctgcagtga cctgaactga tacatgttga ttagtctgcc ctttctttag aaaactgcta     1620



ctctcctttt catatctcag aaaaacagta gaggcctttt aggaccaaac tccatgtcac     1680



actgatgaag agccagtggg ggttagagcg tcctgttaag gcacatgcta acttcccact     1740



caagtctggc agcgctgggg catcagcaca cctcttgcca cccacactga taccagaggg     1800



gaaggctgtg aggtggctgg gggttgagac ttgaggtttc taactttcct ctgcacacct     1860



gtggctacct ggtgtttgtc tcttgattcc ctccacctgc ctcacaccct gcctccgtcg     1920



ggattttcca cctacaccat tcaaaaggaa cataggagag ggcatgaagg ggctaggctg     1980



aagcactctg atgactgggg ccaatttgtg gctgaaaatg aatacatttt ttgaaattta     2040



tggtcatttt caagtgattt agaaggttga tccttagcct catacagtga tgaaataatc     2100



tgtgtgttca gagccaagca ggactttagc aagagtctga ttgtattgtc actatctcgg     2160



ggaaaaaaaa atacaaatac atttctctga tctctgatgg caatgaagtt tgacttgtaa     2220





<210>  105

<211>  195

<212>  PRT

<213>  Homo sapiens



<400>  105



Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln 

1               5                   10                  15      





Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile 

            20                  25                  30          





Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu 

        35                  40                  45              





Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln 

    50                  55                  60                  





Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu 

65                  70                  75                  80  





Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln 

                85                  90                  95      





Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn 

            100                 105                 110         





Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser 

        115                 120                 125             





Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly 

    130                 135                 140                 





His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Val 

145                 150                 155                 160 





Gly Ser Leu Leu Gly Asp Arg Glu Lys Ala Ser Cys Phe Ser Leu Ile 

                165                 170                 175     





Gln Gln Phe Ser Asn Cys Val Tyr Ile Leu Ile Thr Cys Pro Gln Ile 

            180                 185                 190         





Val Ile Phe 

        195 





<210>  106

<211>  3319

<212>  DNA

<213>  Homo sapiens



<400>  106

aaccggaagg ggggctgtga ggacgtgttc cgaggaagcc agagccggag ccgtggcctg       60



cggggccggc gacatggatc ccctgttcca gcaaacgcac aagcaggtcc acgagatcca      120



gtcttgcatg ggacgcctgg agacggcaga caagcagtct gtgcacatag tagaaaacga      180



aatccaagca agcatagacc agatattcag ccgtctagaa cgtctggaga ttttgtccag      240



caaggagccc cctaacaaaa ggcaaaatgc cagacttcgg gttgaccagt taaagtatga      300



tgtccagcac ctgcagactg cgctcagaaa cttccagcat cggcgccatg caagggagca      360



gcaggagaga cagcgagaag agcttctgtc tcgaaccttc accactaacg actctgacac      420



caccatacca atggacgaat cactgcagtt taactcctcc ctccagaaag ttcacaacgg      480



catggatgac ctcattttag atgggcacaa tattttagat ggactgagga cccagagact      540



gaccttgaag gggactcaga agaagatcct tgacattgcc aacatgctgg gcttgtccaa      600



cacagtgatg cggctcatcg agaagcgggc tttccaggac aagtacttta tgataggtgg      660



gatgctgctg acctgtgtgg tcatgttcct cgtggtgcag tacctgacat gagccagcca      720



cgctcagtgg ctgaacagca ttcccacagc ctgcaagtgt gtgtgtgtgt gaaagagaga      780



ggggggccca gaggccgcct tttgaaatgt ttgcctgtct gaactgtgaa gacacttggg      840



agtgattgtg gtctaatttc caacctgctc tgttttctgt gacatcttgg agggggagct      900



agtgccacca ccatgcgcgg tgcttaggaa atgaaagaag tcccgggtct gtctctctca      960



ctctcgctct cactggggga gggaaagaat ggctttggtg gctttgttca catagctgat     1020



gcgtgccctg ggaaggtgtc cacagtgagc cctgtgtgca ggactgtcca cacggttcac     1080



accttgtcac catcaggcct ttctggctcc tgatagggtg gagcaaaagt ggaaaggaaa     1140



ggaaagaggc cttttctcac agccattata ttaaatagta ggtcgattca catcctcgtg     1200



ctcctggcca ccctcccctg tgcctcagtg acatgtagat gactgactgc caatacttgt     1260



caccattccc tggaagcagc tacctagggg aaacaagatg tagtgctatt gccgataaca     1320



agtaagattt tccacactac agctgggtgt ttctcttttc taaagtgagg ccagtgttat     1380



ttcccgggag tgttcagtct tgaccctagt cactgatttt ttctagttgt taatagagtg     1440



gttggctttt aaggttcaga gactgtggct tggcacctgc gcccaggctt tgtgggcctt     1500



tgccccttag aaagtagctg taggcaaaga tttgtgattt tccaattaca gtctcagctc     1560



tagttttagt atctctaatt ctttggttcc cttctcttcc ctgaaatata ttagcacctg     1620



ccagccaggc cctcattttg cccagccagt gtgggcagat cccaccgtgg agacatctgt     1680



agtgtgtatg tccttgtaac actctgtttt cagggactac aacctttttc cttctgtgac     1740



cagccccgga ttcaggctgt actaatacca ggtatattgt ggaatttagt ataaaggcca     1800



atctgtcctg aagtccatct aatgtggtga atcactgaaa gtctcagaaa gacctggtta     1860



gtgtatgttc tcatttacca caggcctacc agccctgggc acagcagctt catggcaaga     1920



cataaaatga cactcaaaat ccttcagatc tggaaaccgg ctcagtatta accctacctt     1980



tggttgtcct gccctacctg ctctgttagt ttcttgttgc ttgaactgtc ttctgtctta     2040



tttcccttcc tttctgtgtt cctcttcacc tctcttgttc ccctccccgc tgctctgtag     2100



tcatgttggt cctttcaggc acctctgtgg catagctccc ctttggtaag ttttcttaat     2160



tgtcatagat taactgagtt tcctggatgc taatttcaca ctttcggttg gaggagatct     2220



ccattgttcc tacccctccg ggccaaatgg gccccaggtt tccaaggaag gagcaatctg     2280



tgactcctaa aatgggttgg ggccctgcca gagttaaagc agtgactgga gggtggactg     2340



gggggttgca gcatctttag acctagatct gtctaactct ggggaggcac attgacattt     2400



ccattacaca cagcactgct gcggtgccag ggacctagcg caggactttt ggtaatccat     2460



aaaatggatt ctgagactgc gacggcaagg ctgtcctgtc ccccaggcac ccaaggatcc     2520



tgccagacag cacactttgg aggaaggtct gcagggagca gctgagccat ttgttcttga     2580



actctgggag gcagaagtcc ccgcacccat catgcgtgga ctgataggac atcttttcgt     2640



ggtgtgcacc agtgctttcc acacttgaca gtggttggct ttgatgaacc ctcatgctgc     2700



accttcagag ccagtcctct agtttggaat aaaaattgca gaggtggttt ttgggtcttt     2760



accacctgcg gctggtggac agcagccagt gtgtctggac acccaggggc attgagactg     2820



catgttgtca catgaccact tctcttcaca catctgcttt cagtgcctgg tgaaaaatag     2880



accttggcct aacagtgtga ctctctccac cgcctcagtg tagggaaggg tccaggccag     2940



ggaaggagca ccctctagtg gaggcggggg tgaattctta ggtcgagctg atgcaagaaa     3000



ctccggtagc cagcctctgt gaccttgtac atgagtttgg tgtgcctatt gtgatttaaa     3060



acaggtgggt tatcaagagg aacttgagat ctctttatta catggacatt tacttcaggg     3120



ggaccactgt aagaaaagcc aaactccaag accaagtaag ttagaggagt cttgattttt     3180



tagacttcac tgcggagttc tgtacaccct ttgccctgat gaatttgaat gggtttgatt     3240



tgcaaatttg gatttacacc cattgttttg gaagcacatc agctgaataa agttgaggtt     3300



tattttattt agaaaatca                                                  3319





<210>  107

<211>  212

<212>  PRT

<213>  Homo sapiens



<400>  107



Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln 

1               5                   10                  15      





Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile 

            20                  25                  30          





Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu 

        35                  40                  45              





Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln 

    50                  55                  60                  





Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu 

65                  70                  75                  80  





Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln 

                85                  90                  95      





Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn 

            100                 105                 110         





Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser 

        115                 120                 125             





Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly 

    130                 135                 140                 





His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Gly 

145                 150                 155                 160 





Thr Gln Lys Lys Ile Leu Asp Ile Ala Asn Met Leu Gly Leu Ser Asn 

                165                 170                 175     





Thr Val Met Arg Leu Ile Glu Lys Arg Ala Phe Gln Asp Lys Tyr Phe 

            180                 185                 190         





Met Ile Gly Gly Met Leu Leu Thr Cys Val Val Met Phe Leu Val Val 

        195                 200                 205             





Gln Tyr Leu Thr 

    210         





<210>  108

<211>  1469

<212>  DNA

<213>  Homo sapiens



<400>  108

aaccggaagg ggggctgtga ggacgtgttc cgaggaagcc agagccggag ccgtggcctg       60



cggggccggc gacatggatc ccctgttcca gcaaacgcac aagcaggtcc acgagatcca      120



gtcttgcatg ggacgcctgg agacggcaga caagcagtct gtgcacatag tagaaaacga      180



aatccaagca agcatagacc agatattcag ccgtctagaa cgtctggaga ttttgtccag      240



caaggagccc cctaacaaaa ggcaaaatgc cagacttcgg gttgaccagt taaagtatga      300



tgtccagcac ctgcagactg cgctcagaaa cttccagcat cggcgccatg caagggagca      360



gcaggagaga cagcgagaag agcttctgtc tcgaaccttc accactaacg actctgacac      420



caccatacca atggacgaat cactgcagtt taactcctcc ctccagaaag ttcacaacgg      480



catggatgac ctcattttag atgggcacaa tattttagat ggactgagga cccagagact      540



gaccttgaag gggactcaga agaagatcct tgacattgcc aacatgctgg gcttgtccaa      600



cacagtgatg cggctcatcg agaagcgggc tttccaggac aagtacttta tgataggcac      660



ccaaggatcc tgccagacag cacactttgg aggaaggtct gcagggagca gctgagccat      720



ttgttcttga actctgggag gcagaagtcc ccgcacccat catgcgtgga ctgataggac      780



atcttttcgt ggtgtgcacc agtgctttcc acacttgaca gtggttggct ttgatgaacc      840



ctcatgctgc accttcagag ccagtcctct agtttggaat aaaaattgca gaggtggttt      900



ttgggtcttt accacctgcg gctggtggac agcagccagt gtgtctggac acccaggggc      960



attgagactg catgttgtca catgaccact tctcttcaca catctgcttt cagtgcctgg     1020



tgaaaaatag accttggcct aacagtgtga ctctctccac cgcctcagtg tagggaaggg     1080



tccaggccag ggaaggagca ccctctagtg gaggcggggg tgaattctta ggtcgagctg     1140



atgcaagaaa ctccggtagc cagcctctgt gaccttgtac atgagtttgg tgtgcctatt     1200



gtgatttaaa acaggtgggt tatcaagagg aacttgagat ctctttatta catggacatt     1260



tacttcaggg ggaccactgt aagaaaagcc aaactccaag accaagtaag ttagaggagt     1320



cttgattttt tagacttcac tgcggagttc tgtacaccct ttgccctgat gaatttgaat     1380



gggtttgatt tgcaaatttg gatttacacc cattgttttg gaagcacatc agctgaataa     1440



agttgaggtt tattttattt agaaaatca                                       1469





<210>  109

<211>  213

<212>  PRT

<213>  Homo sapiens



<400>  109



Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln 

1               5                   10                  15      





Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile 

            20                  25                  30          





Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu 

        35                  40                  45              





Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln 

    50                  55                  60                  





Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu 

65                  70                  75                  80  





Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln 

                85                  90                  95      





Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn 

            100                 105                 110         





Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser 

        115                 120                 125             





Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly 

    130                 135                 140                 





His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Gly 

145                 150                 155                 160 





Thr Gln Lys Lys Ile Leu Asp Ile Ala Asn Met Leu Gly Leu Ser Asn 

                165                 170                 175     





Thr Val Met Arg Leu Ile Glu Lys Arg Ala Phe Gln Asp Lys Tyr Phe 

            180                 185                 190         





Met Ile Gly Thr Gln Gly Ser Cys Gln Thr Ala His Phe Gly Gly Arg 

        195                 200                 205             





Ser Ala Gly Ser Ser 

    210             





<210>  110

<211>  2926

<212>  DNA

<213>  Homo sapiens



<400>  110

cggaagcgga agtcgggggg cgcgccagct cgtagcaggg gagcgcccgc ggcgtcgggt       60



ttgggctgga ggtcgccatg gggcgaggca gcggcacctt cgagcgtctc ctagacaagg      120



cgaccagcca gctcctgttg gagacagatt gggagtccat tttgcagatc tgcgacctga      180



tccgccaagg ggacacacaa gcaaaatatg ctgtgaattc catcaagaag aaagtcaacg      240



acaagaaccc acacgtcgcc ttgtatgccc tggaggtcat ggaatctgtg gtaaagaact      300



gtggccagac agttcatgat gaggtggcca acaagcagac catggaggag ctgaaggacc      360



tgctgaagag acaagtggag gtaaacgtcc gtaacaagat cctgtacctg atccaggcct      420



gggcgcatgc cttccggaac gagcccaagt acaaggtggt ccaggacacc taccagatca      480



tgaaggtgga ggggcacgtc tttccagaat tcaaagagag cgatgccatg tttgctgccg      540



agagagcccc agactgggtg gacgctgagg aatgccaccg ctgcagggtg cagttcgggg      600



tgatgacccg taagcaccac tgccgggcgt gtgggcagat attctgtgga aagtgttctt      660



ccaagtactc caccatcccc aagtttggca tcgagaagga ggtgcgcgtg tgtgagccct      720



gctacgagca gctgaacagg aaagcggagg gaaaggccac ttccaccact gagctgcccc      780



ccgagtacct gaccagcccc ctgtctcagc agtcccagct gccccccaag agggacgaga      840



cggccctgca ggaggaggag gagctgcagc tggccctggc gctgtcacag tcagaggcgg      900



aggagaagga gaggctgaga cagaagtcca cgtacacttc gtaccccaag gcggagccca      960



tgccctcggc ctcctcagcg ccccccgcca gcagcctgta ctcttcacct gtgaactcgt     1020



cggcgcctct ggctgaggac atcgaccctg agctcgcacg gtatctcaac cggaactact     1080



gggagaagaa gcaggaggag gctcgcaaga gccccacgcc atctgcgccc gtgcccctga     1140



cggagccggc tgcacagcct ggggaagggc acgcagcccc caccaacgtg gtggagaacc     1200



ccctcccgga gacagactct cagcccattc ctccctctgg tggccccttt agtgagccac     1260



agttccacaa tggcgagtct gaggagagcc acgagcagtt cctgaaggcg ctgcagaacg     1320



ccgtcaccac cttcgtgaac cgcatgaaga gtaaccacat gcggggccgc agcatcacca     1380



atgactcggc cgtgctctca ctcttccagt ccatcaacgg catgcacccg cagctgctgg     1440



agctgctcaa ccagctggac gagcgcaggc tgtactatga ggggctgcag gacaagctgg     1500



cacagatccg cgatgcccgg ggggcgctga gtgccctgcg cgaagagcac cgggagaagc     1560



ttcgccgggc agccgaggag gcagagcgcc agcgccagat ccagctggcc cagaagctgg     1620



agataatgcg gcagaagaag caggagtacc tggaggtgca gaggcagctg gccatccagc     1680



gcctgcagga gcaggagaag gagcggcaga tgcggctgga gcagcagaag cagacggtcc     1740



agatgcgcgc gcagatgccc gccttccccc tgccctacgc ccagctccag gccatgcccg     1800



cagccggagg tgtgctctac cagccctcgg gaccagccag cttccccagc accttcagcc     1860



ctgccggctc ggtggagggc tccccaatgc acggcgtgta catgagccag ccggcccctg     1920



ccgctggccc ctaccccagc atgcccagca ctgcggctga tcccagcatg gtgagtgcct     1980



acatgtaccc agcaggggcc actggggcgc aggcggcccc ccaggcccag gccggaccca     2040



ccgccagccc cgcttactca tcctaccagc ctactcccac agcgggctac cagaacgtgg     2100



cctcccaggc cccacagagc ctcccggcca tctctcagcc tccgcagtcc agcaccatgg     2160



gctacatggg gagccagtca gtctccatgg gctaccagcc ttacaacatg cagaatctca     2220



tgaccaccct cccaagccag gatgcgtctc tgccacccca gcagccctac atcgcggggc     2280



agcagcccat gtaccagcag atggcaccct ctggcggtcc cccccagcag cagccccccg     2340



tggcccagca accgcaggca caggggccgc cggcacaggg cagcgaggcc cagctcattt     2400



cattcgactg acccaggcca tgctcacgtc cggagtaaca ctacatacag ttcacctgaa     2460



acgcctcgtc tctaactgcc gtcgtcctgc ctccctgtcc tctactgccg gtagtgtccc     2520



ttctctgcga gtgagggggg gccttcaccc caagcccacc tcccttgtcc tcagcctact     2580



gcagtccctg agttagtctc tgctttcttt ccccagggct gggccatggg gagggaagga     2640



ctttctccca ggggaagccc ccagccctgt gggtcatggt ctgtgagagg tggcaggaat     2700



ggggaccctc accccccaag cagcctgtgc cctctggccg cactgtgagc tggctgtggt     2760



gtctgggtgt ggcctggggc tccctctgca ggggcctctc tcggcagcca cagccaaggg     2820



tggaggcttc aggtctccag cttctctgct tctcagctgc catctccagt gccccagaat     2880



ggtacagcga taataaaatg tatttcagaa aaaaaaaaaa aaaaaa                    2926





<210>  111

<211>  777

<212>  PRT

<213>  Homo sapiens



<400>  111



Met Gly Arg Gly Ser Gly Thr Phe Glu Arg Leu Leu Asp Lys Ala Thr 

1               5                   10                  15      





Ser Gln Leu Leu Leu Glu Thr Asp Trp Glu Ser Ile Leu Gln Ile Cys 

            20                  25                  30          





Asp Leu Ile Arg Gln Gly Asp Thr Gln Ala Lys Tyr Ala Val Asn Ser 

        35                  40                  45              





Ile Lys Lys Lys Val Asn Asp Lys Asn Pro His Val Ala Leu Tyr Ala 

    50                  55                  60                  





Leu Glu Val Met Glu Ser Val Val Lys Asn Cys Gly Gln Thr Val His 

65                  70                  75                  80  





Asp Glu Val Ala Asn Lys Gln Thr Met Glu Glu Leu Lys Asp Leu Leu 

                85                  90                  95      





Lys Arg Gln Val Glu Val Asn Val Arg Asn Lys Ile Leu Tyr Leu Ile 

            100                 105                 110         





Gln Ala Trp Ala His Ala Phe Arg Asn Glu Pro Lys Tyr Lys Val Val 

        115                 120                 125             





Gln Asp Thr Tyr Gln Ile Met Lys Val Glu Gly His Val Phe Pro Glu 

    130                 135                 140                 





Phe Lys Glu Ser Asp Ala Met Phe Ala Ala Glu Arg Ala Pro Asp Trp 

145                 150                 155                 160 





Val Asp Ala Glu Glu Cys His Arg Cys Arg Val Gln Phe Gly Val Met 

                165                 170                 175     





Thr Arg Lys His His Cys Arg Ala Cys Gly Gln Ile Phe Cys Gly Lys 

            180                 185                 190         





Cys Ser Ser Lys Tyr Ser Thr Ile Pro Lys Phe Gly Ile Glu Lys Glu 

        195                 200                 205             





Val Arg Val Cys Glu Pro Cys Tyr Glu Gln Leu Asn Arg Lys Ala Glu 

    210                 215                 220                 





Gly Lys Ala Thr Ser Thr Thr Glu Leu Pro Pro Glu Tyr Leu Thr Ser 

225                 230                 235                 240 





Pro Leu Ser Gln Gln Ser Gln Leu Pro Pro Lys Arg Asp Glu Thr Ala 

                245                 250                 255     





Leu Gln Glu Glu Glu Glu Leu Gln Leu Ala Leu Ala Leu Ser Gln Ser 

            260                 265                 270         





Glu Ala Glu Glu Lys Glu Arg Leu Arg Gln Lys Ser Thr Tyr Thr Ser 

        275                 280                 285             





Tyr Pro Lys Ala Glu Pro Met Pro Ser Ala Ser Ser Ala Pro Pro Ala 

    290                 295                 300                 





Ser Ser Leu Tyr Ser Ser Pro Val Asn Ser Ser Ala Pro Leu Ala Glu 

305                 310                 315                 320 





Asp Ile Asp Pro Glu Leu Ala Arg Tyr Leu Asn Arg Asn Tyr Trp Glu 

                325                 330                 335     





Lys Lys Gln Glu Glu Ala Arg Lys Ser Pro Thr Pro Ser Ala Pro Val 

            340                 345                 350         





Pro Leu Thr Glu Pro Ala Ala Gln Pro Gly Glu Gly His Ala Ala Pro 

        355                 360                 365             





Thr Asn Val Val Glu Asn Pro Leu Pro Glu Thr Asp Ser Gln Pro Ile 

    370                 375                 380                 





Pro Pro Ser Gly Gly Pro Phe Ser Glu Pro Gln Phe His Asn Gly Glu 

385                 390                 395                 400 





Ser Glu Glu Ser His Glu Gln Phe Leu Lys Ala Leu Gln Asn Ala Val 

                405                 410                 415     





Thr Thr Phe Val Asn Arg Met Lys Ser Asn His Met Arg Gly Arg Ser 

            420                 425                 430         





Ile Thr Asn Asp Ser Ala Val Leu Ser Leu Phe Gln Ser Ile Asn Gly 

        435                 440                 445             





Met His Pro Gln Leu Leu Glu Leu Leu Asn Gln Leu Asp Glu Arg Arg 

    450                 455                 460                 





Leu Tyr Tyr Glu Gly Leu Gln Asp Lys Leu Ala Gln Ile Arg Asp Ala 

465                 470                 475                 480 





Arg Gly Ala Leu Ser Ala Leu Arg Glu Glu His Arg Glu Lys Leu Arg 

                485                 490                 495     





Arg Ala Ala Glu Glu Ala Glu Arg Gln Arg Gln Ile Gln Leu Ala Gln 

            500                 505                 510         





Lys Leu Glu Ile Met Arg Gln Lys Lys Gln Glu Tyr Leu Glu Val Gln 

        515                 520                 525             





Arg Gln Leu Ala Ile Gln Arg Leu Gln Glu Gln Glu Lys Glu Arg Gln 

    530                 535                 540                 





Met Arg Leu Glu Gln Gln Lys Gln Thr Val Gln Met Arg Ala Gln Met 

545                 550                 555                 560 





Pro Ala Phe Pro Leu Pro Tyr Ala Gln Leu Gln Ala Met Pro Ala Ala 

                565                 570                 575     





Gly Gly Val Leu Tyr Gln Pro Ser Gly Pro Ala Ser Phe Pro Ser Thr 

            580                 585                 590         





Phe Ser Pro Ala Gly Ser Val Glu Gly Ser Pro Met His Gly Val Tyr 

        595                 600                 605             





Met Ser Gln Pro Ala Pro Ala Ala Gly Pro Tyr Pro Ser Met Pro Ser 

    610                 615                 620                 





Thr Ala Ala Asp Pro Ser Met Val Ser Ala Tyr Met Tyr Pro Ala Gly 

625                 630                 635                 640 





Ala Thr Gly Ala Gln Ala Ala Pro Gln Ala Gln Ala Gly Pro Thr Ala 

                645                 650                 655     





Ser Pro Ala Tyr Ser Ser Tyr Gln Pro Thr Pro Thr Ala Gly Tyr Gln 

            660                 665                 670         





Asn Val Ala Ser Gln Ala Pro Gln Ser Leu Pro Ala Ile Ser Gln Pro 

        675                 680                 685             





Pro Gln Ser Ser Thr Met Gly Tyr Met Gly Ser Gln Ser Val Ser Met 

    690                 695                 700                 





Gly Tyr Gln Pro Tyr Asn Met Gln Asn Leu Met Thr Thr Leu Pro Ser 

705                 710                 715                 720 





Gln Asp Ala Ser Leu Pro Pro Gln Gln Pro Tyr Ile Ala Gly Gln Gln 

                725                 730                 735     





Pro Met Tyr Gln Gln Met Ala Pro Ser Gly Gly Pro Pro Gln Gln Gln 

            740                 745                 750         





Pro Pro Val Ala Gln Gln Pro Gln Ala Gln Gly Pro Pro Ala Gln Gly 

        755                 760                 765             





Ser Glu Ala Gln Leu Ile Ser Phe Asp 

    770                 775         





<210>  112

<211>  1744

<212>  DNA

<213>  Homo sapiens



<400>  112

cggcggtggg cggggctcac gcgaggcgct ggaacggtcc gggagattct cgctctgctg       60



ctttagcttc ggagtgtttg gcgatggggc agcgcgagat gtggaggctc atgtcgaggt      120



ttaatgcatt caaaaggact aataccatac tgcaccattt gagaatgtcc aagcacacag      180



atgcagcaga agaggtgcta ttggaaaaaa aaggttgcac gggagtcata acactaaaca      240



gaccaaagtt cctcaatgca ctgactctta atatgattcg gcagatttat ccacagctaa      300



agaagtggga acaagatcct gaaactttcc tgatcattat aaagggagca ggaggaaagg      360



ctttctgtgc cgggggtgat atcagagtga tctcggaagc tgaaaaggca aaacagaaga      420



tagctccagt tttcttcaga gaagaatata tgctgaataa tgctgttggt tcttgccaga      480



aaccttatgt tgcacttatt catggaatta caatgggtgg gggagttggt ctctcagtcc      540



atgggcaatt tcgagtggct acagaaaagt gtctttttgc tatgccagaa actgcaatag      600



gactgttccc tgatgtgggt ggaggttatt tcttgccacg actccaagga aaacttggtt      660



acttccttgc attaacagga ttcagactaa aaggaagaga tgtgtacaga gcaggaattg      720



ctacacactt tgtagattct gaaaagttgg ccatgttaga ggaagatttg ttagccttga      780



aatctccttc aaaagaaaat attgcatctg tcttagaaaa ttaccataca gagtctaaga      840



ttgatcgaga caagtctttt atacttgagg aacacatgga caaaataaac agttgttttt      900



cagccaatac tgtggaagaa attattgaaa acttacagca agatggttca tcttttgccc      960



tagagcaatt gaaggtaatt aataaaatgt ctccaacatc tctaaagatc acactaaggc     1020



aactcatgga ggggtcttca aagaccttgc aagaagtact aactatggag tatcggctaa     1080



gtcaagcttg tatgagaggt catgactttc atgaaggcgt tagagctgtt ttaattgata     1140



aagaccagag tccaaaatgg aaaccagctg atctaaaaga agttactgag gaagatttga     1200



ataatcactt taagtctttg ggaagcagtg atttgaaatt ttgaggtgac aggcttttaa     1260



ggtatatttt gtagcatggg ttggcaatct acagcatgtg ggccaaatcc agcctgctgc     1320



ctgtttttat ataccctgta agctaagaat ggtttccgca tttttaaatg gttgggaaaa     1380



gaaatcaaag actaataatt catgacgtga aaattatcag aattcacaaa taaagcttta     1440



ttggaactag ctatactcat ctgtttatat attatctgtg gctgctttga aatgagtagt     1500



tgcaatagag atggtaaagc ctacaaagcc taattattta ctgtctggtt tttgtcagaa     1560



aaaagtttgt caatccttgt tttagaagat ggaaaaatgt gaagatcttt ggagattctc     1620



ttgagtggta tatctaattg aaatgggatc ttcgtttggc ttgtatgttg atgaaatcaa     1680



cttaggtata caatataaaa aataaagacc ctgaaaattg ttttggaaaa aaaaaaaaaa     1740



aaaa                                                                  1744





<210>  113

<211>  386

<212>  PRT

<213>  Homo sapiens



<400>  113



Met Gly Gln Arg Glu Met Trp Arg Leu Met Ser Arg Phe Asn Ala Phe 

1               5                   10                  15      





Lys Arg Thr Asn Thr Ile Leu His His Leu Arg Met Ser Lys His Thr 

            20                  25                  30          





Asp Ala Ala Glu Glu Val Leu Leu Glu Lys Lys Gly Cys Thr Gly Val 

        35                  40                  45              





Ile Thr Leu Asn Arg Pro Lys Phe Leu Asn Ala Leu Thr Leu Asn Met 

    50                  55                  60                  





Ile Arg Gln Ile Tyr Pro Gln Leu Lys Lys Trp Glu Gln Asp Pro Glu 

65                  70                  75                  80  





Thr Phe Leu Ile Ile Ile Lys Gly Ala Gly Gly Lys Ala Phe Cys Ala 

                85                  90                  95      





Gly Gly Asp Ile Arg Val Ile Ser Glu Ala Glu Lys Ala Lys Gln Lys 

            100                 105                 110         





Ile Ala Pro Val Phe Phe Arg Glu Glu Tyr Met Leu Asn Asn Ala Val 

        115                 120                 125             





Gly Ser Cys Gln Lys Pro Tyr Val Ala Leu Ile His Gly Ile Thr Met 

    130                 135                 140                 





Gly Gly Gly Val Gly Leu Ser Val His Gly Gln Phe Arg Val Ala Thr 

145                 150                 155                 160 





Glu Lys Cys Leu Phe Ala Met Pro Glu Thr Ala Ile Gly Leu Phe Pro 

                165                 170                 175     





Asp Val Gly Gly Gly Tyr Phe Leu Pro Arg Leu Gln Gly Lys Leu Gly 

            180                 185                 190         





Tyr Phe Leu Ala Leu Thr Gly Phe Arg Leu Lys Gly Arg Asp Val Tyr 

        195                 200                 205             





Arg Ala Gly Ile Ala Thr His Phe Val Asp Ser Glu Lys Leu Ala Met 

    210                 215                 220                 





Leu Glu Glu Asp Leu Leu Ala Leu Lys Ser Pro Ser Lys Glu Asn Ile 

225                 230                 235                 240 





Ala Ser Val Leu Glu Asn Tyr His Thr Glu Ser Lys Ile Asp Arg Asp 

                245                 250                 255     





Lys Ser Phe Ile Leu Glu Glu His Met Asp Lys Ile Asn Ser Cys Phe 

            260                 265                 270         





Ser Ala Asn Thr Val Glu Glu Ile Ile Glu Asn Leu Gln Gln Asp Gly 

        275                 280                 285             





Ser Ser Phe Ala Leu Glu Gln Leu Lys Val Ile Asn Lys Met Ser Pro 

    290                 295                 300                 





Thr Ser Leu Lys Ile Thr Leu Arg Gln Leu Met Glu Gly Ser Ser Lys 

305                 310                 315                 320 





Thr Leu Gln Glu Val Leu Thr Met Glu Tyr Arg Leu Ser Gln Ala Cys 

                325                 330                 335     





Met Arg Gly His Asp Phe His Glu Gly Val Arg Ala Val Leu Ile Asp 

            340                 345                 350         





Lys Asp Gln Ser Pro Lys Trp Lys Pro Ala Asp Leu Lys Glu Val Thr 

        355                 360                 365             





Glu Glu Asp Leu Asn Asn His Phe Lys Ser Leu Gly Ser Ser Asp Leu 

    370                 375                 380                 





Lys Phe 

385     





<210>  114

<211>  1710

<212>  DNA

<213>  Homo sapiens



<400>  114

cggcggtggg cggggctcac gcgaggcgct ggaacggtcc gggagattct cgctctgctg       60



ctttagcttc ggagtgtttg gcgatggggc agcgcgagat gtggaggctc atgtcgaggt      120



ttaatgcatt caaaaggact aataccatac tgcaccattt gagaatgtcc aagcacacag      180



atgcagcaga agaggtgcta ttggaaaaaa aaggttgcac gggagtcata acactaaaca      240



gaccaaagtt cctcaatgca ctgactctta atatgattcg gcagatttat ccacagctaa      300



agaagtggga acaagatcct gaaactttcc tgatcattat aaagggagca ggaggaaagg      360



ctttctgtgc cgggggtgat atcagagtga tctcggaagc tgaaaaggca aaacagaaga      420



tagctccagt tttcttcaga gaagaatata tgctgaataa tgctgttggt tcttgccaga      480



aaccttatgt tgcacttatt catggaatta caatgggtgg gggagttggt ctctcagtcc      540



atgggcaatt tcgagtggct acagaaaagt gtctttttgc tatgccagaa actgcaatag      600



gactgttccc tgatgtgggt ggaggttatt tcttgccacg actccaagga aaacttggtt      660



acttccttgc attaacagga ttcagactaa aaggaagaga tgtgtacaga gcaggaattg      720



ctacacactt tgtagattct gaaaagttgg ccatgttaga ggaagatttg ttagccttga      780



aatctccttc aaaagaaaat attgcatctg tcttagaaaa ttaccataca gagtctaaga      840



ttgatcgaga caagtctttt atacttgagg aacacatgga caaaataaac agttgttttt      900



cagccaatac tgtggaagaa attattgaaa acttacagca agatggttca tcttttgccc      960



tagagcaatt gaaggtaatt aataaaatgt ctccaacatc tctaaagatc acactaaggc     1020



aactcatgga ggggtcttca aagaccttgc aagaagtact aactatggag tatcggctaa     1080



gtcaagcttg tatgttttaa ttgataaaga ccagagtcca aaatggaaac cagctgatct     1140



aaaagaagtt actgaggaag atttgaataa tcactttaag tctttgggaa gcagtgattt     1200



gaaattttga ggtgacaggc ttttaaggta tattttgtag catgggttgg caatctacag     1260



catgtgggcc aaatccagcc tgctgcctgt ttttatatac cctgtaagct aagaatggtt     1320



tccgcatttt taaatggttg ggaaaagaaa tcaaagacta ataattcatg acgtgaaaat     1380



tatcagaatt cacaaataaa gctttattgg aactagctat actcatctgt ttatatatta     1440



tctgtggctg ctttgaaatg agtagttgca atagagatgg taaagcctac aaagcctaat     1500



tatttactgt ctggtttttg tcagaaaaaa gtttgtcaat ccttgtttta gaagatggaa     1560



aaatgtgaag atctttggag attctcttga gtggtatatc taattgaaat gggatcttcg     1620



tttggcttgt atgttgatga aatcaactta ggtatacaat ataaaaaata aagaccctga     1680



aaattgtttt ggaaaaaaaa aaaaaaaaaa                                      1710





<210>  115

<211>  338

<212>  PRT

<213>  Homo sapiens



<400>  115



Met Gly Gln Arg Glu Met Trp Arg Leu Met Ser Arg Phe Asn Ala Phe 

1               5                   10                  15      





Lys Arg Thr Asn Thr Ile Leu His His Leu Arg Met Ser Lys His Thr 

            20                  25                  30          





Asp Ala Ala Glu Glu Val Leu Leu Glu Lys Lys Gly Cys Thr Gly Val 

        35                  40                  45              





Ile Thr Leu Asn Arg Pro Lys Phe Leu Asn Ala Leu Thr Leu Asn Met 

    50                  55                  60                  





Ile Arg Gln Ile Tyr Pro Gln Leu Lys Lys Trp Glu Gln Asp Pro Glu 

65                  70                  75                  80  





Thr Phe Leu Ile Ile Ile Lys Gly Ala Gly Gly Lys Ala Phe Cys Ala 

                85                  90                  95      





Gly Gly Asp Ile Arg Val Ile Ser Glu Ala Glu Lys Ala Lys Gln Lys 

            100                 105                 110         





Ile Ala Pro Val Phe Phe Arg Glu Glu Tyr Met Leu Asn Asn Ala Val 

        115                 120                 125             





Gly Ser Cys Gln Lys Pro Tyr Val Ala Leu Ile His Gly Ile Thr Met 

    130                 135                 140                 





Gly Gly Gly Val Gly Leu Ser Val His Gly Gln Phe Arg Val Ala Thr 

145                 150                 155                 160 





Glu Lys Cys Leu Phe Ala Met Pro Glu Thr Ala Ile Gly Leu Phe Pro 

                165                 170                 175     





Asp Val Gly Gly Gly Tyr Phe Leu Pro Arg Leu Gln Gly Lys Leu Gly 

            180                 185                 190         





Tyr Phe Leu Ala Leu Thr Gly Phe Arg Leu Lys Gly Arg Asp Val Tyr 

        195                 200                 205             





Arg Ala Gly Ile Ala Thr His Phe Val Asp Ser Glu Lys Leu Ala Met 

    210                 215                 220                 





Leu Glu Glu Asp Leu Leu Ala Leu Lys Ser Pro Ser Lys Glu Asn Ile 

225                 230                 235                 240 





Ala Ser Val Leu Glu Asn Tyr His Thr Glu Ser Lys Ile Asp Arg Asp 

                245                 250                 255     





Lys Ser Phe Ile Leu Glu Glu His Met Asp Lys Ile Asn Ser Cys Phe 

            260                 265                 270         





Ser Ala Asn Thr Val Glu Glu Ile Ile Glu Asn Leu Gln Gln Asp Gly 

        275                 280                 285             





Ser Ser Phe Ala Leu Glu Gln Leu Lys Val Ile Asn Lys Met Ser Pro 

    290                 295                 300                 





Thr Ser Leu Lys Ile Thr Leu Arg Gln Leu Met Glu Gly Ser Ser Lys 

305                 310                 315                 320 





Thr Leu Gln Glu Val Leu Thr Met Glu Tyr Arg Leu Ser Gln Ala Cys 

                325                 330                 335     





Met Phe 

        





<210>  116

<211>  3037

<212>  DNA

<213>  Homo sapiens



<400>  116

agtggccctc gccccgcccc aaacccgacc ccggtgggcg tcgacgcgca gcagcagcgg       60



gtccccccaa ccccggcgcc ccgcctcccc gggcctcgcg ccgcatgccg gcgtcggcgc      120



tttttgacgc catagtgggc gtgtcggcgc gacccgcgac gtcgccacgc gccgacaatg      180



gcggctgcgt cggcctgagc agggcttagt ttagaagtaa tttcctgacg ttgccgaggg      240



agccgcagtc gcctcagatc cggtcggcgg cggcggcggt ggcggcggcg gcagcgcgcc      300



tgcgcgctcc cgcagcgccc tggacctagc ggcggtgccg aggcccggcg gagcaagcca      360



gctccagcgt catttcggcc tcttagttct tctgaaccct gctcctgagc taggtaggaa      420



acatgagcgg caccaacttg gatgggaacg atgagtttga tgagcagttg cgaatgcaag      480



aattgtacgg agacggcaag gatggtgaca cccagaccga tgccggcgga gaacccgatt      540



ctctcgggca gcagccgacg gacactccct acgagtggga cctggacaaa aaggcttggt      600



tccccaagat tactgaagat ttcattgcta catatcaggc caattatggc ttctctaacg      660



atggcgcatc tagttctacc gcaaatgttg aagatgtcca tgctaggact gcagaggaac      720



ctccacaaga aaaagccccg gaacccactg atgccagaaa gaagggagaa aaaagaaagg      780



ctgagtcagg atggtttcat gttgaagaag acagaaatac aaatgtatac gtgtctggtt      840



tgcctccaga tattacagtg gatgaattta tacaacttat gtccaagttt ggcattatta      900



tgagagatcc tcagacagaa gaatttaagg tcaaacttta caaagataat caaggaaatc      960



ttaaaggaga cggtctttgc tgttatttga aaagagaatc tgtggaactt gcattaaaac     1020



ttttggatga agatgaaatt agaggctaca aattacatgt tgaggtggca aagtttcaac     1080



tgaagggaga atatgatgcc tcaaagaaga agaagaagtg caaagactat aagaagaagc     1140



tgtctatgca acaaaagcag ttggattgga gacctgagag gcgagccgga ccatcccgga     1200



tgcgccatga gcgagttgtc atcatcaaga atatgtttca tcctatggat tttgaggatg     1260



atccgttggt gctgaatgag atcagagaag accttcgagt agagtgttcg aagtttggac     1320



aaattaggaa actccttctc tttgataggc acccagatgg tgtggcctct gtgtcctttc     1380



gggatccaga ggaagctgat tattgtattc agactctcga tggaagatgg tttggtggcc     1440



gtcaaatcac tgcccaggca tgggatggga ctacagatta tcaggtggag gaaacctcaa     1500



gagaaaggga ggaaaggctg agaggatggg aggctttcct caatgctcct gaggccaaca     1560



gaggccttag gcgttcagat tctgtctctg cttccgaaag ggcagggcct tctagagcaa     1620



ggcatttttc agagcacccc agcacatcta aaatgaatgc tcaagaaact gcaactggaa     1680



tggcgtttga agaacctata gatgagaaga agtttgaaaa gacagaagat gggggagaat     1740



ttgaagaagg tgcttctgaa aacaatgcta aggaaagtag ccccgaaaaa gaggctgaag     1800



aaggctgccc tgaaaaagaa tctgaagagg gctgccccaa aagagggttt gaaggcagct     1860



gctcccaaaa agagtctgaa gaaggcaatc ccgtaagagg atctgaagag gatagtccta     1920



aaaaagagtc taaaaagaag acactcaaaa atgattgtga agagaatggc cttgcaaagg     1980



aatctgaaga tgacctcaac aaggagtctg aagaggaggt tggccccaca aaagagtccg     2040



aagaagatga ctcagagaaa gagtctgatg aagactgctc tgaaaaacag tctgaagatg     2100



gctccgaaag agaatttgaa gaaaatggtc tcgagaaaga tttggacgag gaaggttctg     2160



aaaaggagct tcatgaaaat gttcttgaca aagagttaga agaaaatgac tctgaaaact     2220



ccgaatttga agatgacggc tctgaaaaag tgttagatga ggaaggctct gagagagagt     2280



ttgacgaaga ttcagatgaa aaggaagaag aggaggatac atatgaaaaa gtatttgatg     2340



atgagtctga tgagaaagag gatgaagaat atgcagatga aaaggggctt gaagctgctg     2400



ataaaaaggc ggaagaaggt gatgcagatg aaaagctgtt tgaagagtca gatgacaagg     2460



aagatgaaga tgcagatgga aaggaagttg aagatgctga cgaaaagttg ttcgaagatg     2520



atgattccaa tgagaagttg tttgatgagg aggaagattc cagtgagaag ttgtttgacg     2580



attctgatga gagggggact ttgggtggtt ttgggagtgt tgaagaaggg cccctatcca     2640



ctggcagcag ctttattctc agtagcgatg atgatgacga tgatatttaa tcccttaaac     2700



ttgcttttta gggagagtcc tccatctaca tttgcctgtg cttcagggta attactagta     2760



gtgttacatg aacatgtgca tagtggtagg atgccatcag attaaagcat tgaagtgttt     2820



cattgttacc tgtacctaat ggttttaaat atatgttaat tgattgttta gttaaaatgt     2880



catagttaca atgcaagtaa actggatact tgttcttttg tcagatttgt taaatgcatg     2940



cagaataata tttttaagag tattgattga agtttgtgat attcatcaat aaaaatgagt     3000



tgataatatg cagaaactga aaaaaaaaaa aaaaaaa                              3037





<210>  117

<211>  755

<212>  PRT

<213>  Homo sapiens



<400>  117



Met Ser Gly Thr Asn Leu Asp Gly Asn Asp Glu Phe Asp Glu Gln Leu 

1               5                   10                  15      





Arg Met Gln Glu Leu Tyr Gly Asp Gly Lys Asp Gly Asp Thr Gln Thr 

            20                  25                  30          





Asp Ala Gly Gly Glu Pro Asp Ser Leu Gly Gln Gln Pro Thr Asp Thr 

        35                  40                  45              





Pro Tyr Glu Trp Asp Leu Asp Lys Lys Ala Trp Phe Pro Lys Ile Thr 

    50                  55                  60                  





Glu Asp Phe Ile Ala Thr Tyr Gln Ala Asn Tyr Gly Phe Ser Asn Asp 

65                  70                  75                  80  





Gly Ala Ser Ser Ser Thr Ala Asn Val Glu Asp Val His Ala Arg Thr 

                85                  90                  95      





Ala Glu Glu Pro Pro Gln Glu Lys Ala Pro Glu Pro Thr Asp Ala Arg 

            100                 105                 110         





Lys Lys Gly Glu Lys Arg Lys Ala Glu Ser Gly Trp Phe His Val Glu 

        115                 120                 125             





Glu Asp Arg Asn Thr Asn Val Tyr Val Ser Gly Leu Pro Pro Asp Ile 

    130                 135                 140                 





Thr Val Asp Glu Phe Ile Gln Leu Met Ser Lys Phe Gly Ile Ile Met 

145                 150                 155                 160 





Arg Asp Pro Gln Thr Glu Glu Phe Lys Val Lys Leu Tyr Lys Asp Asn 

                165                 170                 175     





Gln Gly Asn Leu Lys Gly Asp Gly Leu Cys Cys Tyr Leu Lys Arg Glu 

            180                 185                 190         





Ser Val Glu Leu Ala Leu Lys Leu Leu Asp Glu Asp Glu Ile Arg Gly 

        195                 200                 205             





Tyr Lys Leu His Val Glu Val Ala Lys Phe Gln Leu Lys Gly Glu Tyr 

    210                 215                 220                 





Asp Ala Ser Lys Lys Lys Lys Lys Cys Lys Asp Tyr Lys Lys Lys Leu 

225                 230                 235                 240 





Ser Met Gln Gln Lys Gln Leu Asp Trp Arg Pro Glu Arg Arg Ala Gly 

                245                 250                 255     





Pro Ser Arg Met Arg His Glu Arg Val Val Ile Ile Lys Asn Met Phe 

            260                 265                 270         





His Pro Met Asp Phe Glu Asp Asp Pro Leu Val Leu Asn Glu Ile Arg 

        275                 280                 285             





Glu Asp Leu Arg Val Glu Cys Ser Lys Phe Gly Gln Ile Arg Lys Leu 

    290                 295                 300                 





Leu Leu Phe Asp Arg His Pro Asp Gly Val Ala Ser Val Ser Phe Arg 

305                 310                 315                 320 





Asp Pro Glu Glu Ala Asp Tyr Cys Ile Gln Thr Leu Asp Gly Arg Trp 

                325                 330                 335     





Phe Gly Gly Arg Gln Ile Thr Ala Gln Ala Trp Asp Gly Thr Thr Asp 

            340                 345                 350         





Tyr Gln Val Glu Glu Thr Ser Arg Glu Arg Glu Glu Arg Leu Arg Gly 

        355                 360                 365             





Trp Glu Ala Phe Leu Asn Ala Pro Glu Ala Asn Arg Gly Leu Arg Arg 

    370                 375                 380                 





Ser Asp Ser Val Ser Ala Ser Glu Arg Ala Gly Pro Ser Arg Ala Arg 

385                 390                 395                 400 





His Phe Ser Glu His Pro Ser Thr Ser Lys Met Asn Ala Gln Glu Thr 

                405                 410                 415     





Ala Thr Gly Met Ala Phe Glu Glu Pro Ile Asp Glu Lys Lys Phe Glu 

            420                 425                 430         





Lys Thr Glu Asp Gly Gly Glu Phe Glu Glu Gly Ala Ser Glu Asn Asn 

        435                 440                 445             





Ala Lys Glu Ser Ser Pro Glu Lys Glu Ala Glu Glu Gly Cys Pro Glu 

    450                 455                 460                 





Lys Glu Ser Glu Glu Gly Cys Pro Lys Arg Gly Phe Glu Gly Ser Cys 

465                 470                 475                 480 





Ser Gln Lys Glu Ser Glu Glu Gly Asn Pro Val Arg Gly Ser Glu Glu 

                485                 490                 495     





Asp Ser Pro Lys Lys Glu Ser Lys Lys Lys Thr Leu Lys Asn Asp Cys 

            500                 505                 510         





Glu Glu Asn Gly Leu Ala Lys Glu Ser Glu Asp Asp Leu Asn Lys Glu 

        515                 520                 525             





Ser Glu Glu Glu Val Gly Pro Thr Lys Glu Ser Glu Glu Asp Asp Ser 

    530                 535                 540                 





Glu Lys Glu Ser Asp Glu Asp Cys Ser Glu Lys Gln Ser Glu Asp Gly 

545                 550                 555                 560 





Ser Glu Arg Glu Phe Glu Glu Asn Gly Leu Glu Lys Asp Leu Asp Glu 

                565                 570                 575     





Glu Gly Ser Glu Lys Glu Leu His Glu Asn Val Leu Asp Lys Glu Leu 

            580                 585                 590         





Glu Glu Asn Asp Ser Glu Asn Ser Glu Phe Glu Asp Asp Gly Ser Glu 

        595                 600                 605             





Lys Val Leu Asp Glu Glu Gly Ser Glu Arg Glu Phe Asp Glu Asp Ser 

    610                 615                 620                 





Asp Glu Lys Glu Glu Glu Glu Asp Thr Tyr Glu Lys Val Phe Asp Asp 

625                 630                 635                 640 





Glu Ser Asp Glu Lys Glu Asp Glu Glu Tyr Ala Asp Glu Lys Gly Leu 

                645                 650                 655     





Glu Ala Ala Asp Lys Lys Ala Glu Glu Gly Asp Ala Asp Glu Lys Leu 

            660                 665                 670         





Phe Glu Glu Ser Asp Asp Lys Glu Asp Glu Asp Ala Asp Gly Lys Glu 

        675                 680                 685             





Val Glu Asp Ala Asp Glu Lys Leu Phe Glu Asp Asp Asp Ser Asn Glu 

    690                 695                 700                 





Lys Leu Phe Asp Glu Glu Glu Asp Ser Ser Glu Lys Leu Phe Asp Asp 

705                 710                 715                 720 





Ser Asp Glu Arg Gly Thr Leu Gly Gly Phe Gly Ser Val Glu Glu Gly 

                725                 730                 735     





Pro Leu Ser Thr Gly Ser Ser Phe Ile Leu Ser Ser Asp Asp Asp Asp 

            740                 745                 750         





Asp Asp Ile 

        755 





<210>  118

<211>  2788

<212>  DNA

<213>  Homo sapiens



<400>  118

cagccgccga gcggccgcga tttcccgggg actgctgggg cgcagcgggg aggcgggccg       60



gggggcggcg gggcgcgagc agagcgcggt tgacctccct ttctctgctc agctccagcg      120



tcatttcggc ctcttagttc ttctgaaccc tgctcctgag ctaggtagga aacatgagcg      180



gcaccaactt ggatgggaac gatgagtttg atgagcagtt gcgaatgcaa gaattgtacg      240



gagacggcaa ggatggtgac acccagaccg atgccggcgg agaacccgat tctctcgggc      300



agcagccgac ggacactccc tacgagtggg acctggacaa aaaggcttgg ttccccaaga      360



ttactgaaga tttcattgct acatatcagg ccaattatgg cttctctaac gatggcgcat      420



ctagttctac cgcaaatgtt gaagatgtcc atgctaggac tgcagaggaa cctccacaag      480



aaaaagcccc ggaacccact gatgccagaa agaagggaga aaaaagaaag gctgagtcag      540



gatggtttca tgttgaagaa gacagaaata caaatgtata cgtgtctggt ttgcctccag      600



atattacagt ggatgaattt atacaactta tgtccaagtt tggcattatt atgagagatc      660



ctcagacaga agaatttaag gtcaaacttt acaaagataa tcaaggaaat cttaaaggag      720



acggtctttg ctgttatttg aaaagagaat ctgtggaact tgcattaaaa cttttggatg      780



aagatgaaat tagaggctac aaattacatg ttgaggtggc aaagtttcaa ctgaagggag      840



aatatgatgc ctcaaagaag aagaagaagt gcaaagacta taagaagaag ctgtctatgc      900



aacaaaagca gttggattgg agacctgaga ggcgagccgg accatcccgg atgcgccatg      960



agcgagttgt catcatcaag aatatgtttc atcctatgga ttttgaggat gatccgttgg     1020



tgctgaatga gatcagagaa gaccttcgag tagagtgttc gaagtttgga caaattagga     1080



aactccttct ctttgatagg cacccagatg gtgtggcctc tgtgtccttt cgggatccag     1140



aggaagctga ttattgtatt cagactctcg atggaagatg gtttggtggc cgtcaaatca     1200



ctgcccaggc atgggatggg actacagatt atcaggtgga ggaaacctca agagaaaggg     1260



aggaaaggct gagaggatgg gaggctttcc tcaatgctcc tgaggccaac agaggcctta     1320



ggcgttcaga ttctgtctct gcttccgaaa gggcagggcc ttctagagca aggcattttt     1380



cagagcaccc cagcacatct aaaatgaatg ctcaagaaac tgcaactgga atggcgtttg     1440



aagaacctat agatgagaag aagtttgaaa agacagaaga tgggggagaa tttgaagaag     1500



gtgcttctga aaacaatgct aaggaaagta gccccgaaaa agaggctgaa gaaggctgcc     1560



ctgaaaaaga atctgaagag ggctgcccca aaagagggtt tgaaggcagc tgctcccaaa     1620



aagagtctga agaaggcaat cccgtaagag gatctgaaga ggatagtcct aaaaaagagt     1680



ctaaaaagaa gacactcaaa aatgattgtg aagagaatgg ccttgcaaag gaatctgaag     1740



atgacctcaa caaggagtct gaagaggagg ttggccccac aaaagagtcc gaagaagatg     1800



actcagagaa agagtctgat gaagactgct ctgaaaaaca gtctgaagat ggctccgaaa     1860



gagaatttga agaaaatggt ctcgagaaag atttggacga ggaaggttct gaaaaggagc     1920



ttcatgaaaa tgttcttgac aaagagttag aagaaaatga ctctgaaaac tccgaatttg     1980



aagatgacgg ctctgaaaaa gtgttagatg aggaaggctc tgagagagag tttgacgaag     2040



attcagatga aaaggaagaa gaggaggata catatgaaaa agtatttgat gatgagtctg     2100



atgagaaaga ggatgaagaa tatgcagatg aaaaggggct tgaagctgct gataaaaagg     2160



cggaagaagg tgatgcagat gaaaagctgt ttgaagagtc agatgacaag gaagatgaag     2220



atgcagatgg aaaggaagtt gaagatgctg acgaaaagtt gttcgaagat gatgattcca     2280



atgagaagtt gtttgatgag gaggaagatt ccagtgagaa gttgtttgac gattctgatg     2340



agagggggac tttgggtggt tttgggagtg ttgaagaagg gcccctatcc actggcagca     2400



gctttattct cagtagcgat gatgatgacg atgatattta atcccttaaa cttgcttttt     2460



agggagagtc ctccatctac atttgcctgt gcttcagggt aattactagt agtgttacat     2520



gaacatgtgc atagtggtag gatgccatca gattaaagca ttgaagtgtt tcattgttac     2580



ctgtacctaa tggttttaaa tatatgttaa ttgattgttt agttaaaatg tcatagttac     2640



aatgcaagta aactggatac ttgttctttt gtcagatttg ttaaatgcat gcagaataat     2700



atttttaaga gtattgattg aagtttgtga tattcatcaa taaaaatgag ttgataatat     2760



gcagaaactg aaaaaaaaaa aaaaaaaa                                        2788





<210>  119

<211>  755

<212>  PRT

<213>  Homo sapiens



<400>  119



Met Ser Gly Thr Asn Leu Asp Gly Asn Asp Glu Phe Asp Glu Gln Leu 

1               5                   10                  15      





Arg Met Gln Glu Leu Tyr Gly Asp Gly Lys Asp Gly Asp Thr Gln Thr 

            20                  25                  30          





Asp Ala Gly Gly Glu Pro Asp Ser Leu Gly Gln Gln Pro Thr Asp Thr 

        35                  40                  45              





Pro Tyr Glu Trp Asp Leu Asp Lys Lys Ala Trp Phe Pro Lys Ile Thr 

    50                  55                  60                  





Glu Asp Phe Ile Ala Thr Tyr Gln Ala Asn Tyr Gly Phe Ser Asn Asp 

65                  70                  75                  80  





Gly Ala Ser Ser Ser Thr Ala Asn Val Glu Asp Val His Ala Arg Thr 

                85                  90                  95      





Ala Glu Glu Pro Pro Gln Glu Lys Ala Pro Glu Pro Thr Asp Ala Arg 

            100                 105                 110         





Lys Lys Gly Glu Lys Arg Lys Ala Glu Ser Gly Trp Phe His Val Glu 

        115                 120                 125             





Glu Asp Arg Asn Thr Asn Val Tyr Val Ser Gly Leu Pro Pro Asp Ile 

    130                 135                 140                 





Thr Val Asp Glu Phe Ile Gln Leu Met Ser Lys Phe Gly Ile Ile Met 

145                 150                 155                 160 





Arg Asp Pro Gln Thr Glu Glu Phe Lys Val Lys Leu Tyr Lys Asp Asn 

                165                 170                 175     





Gln Gly Asn Leu Lys Gly Asp Gly Leu Cys Cys Tyr Leu Lys Arg Glu 

            180                 185                 190         





Ser Val Glu Leu Ala Leu Lys Leu Leu Asp Glu Asp Glu Ile Arg Gly 

        195                 200                 205             





Tyr Lys Leu His Val Glu Val Ala Lys Phe Gln Leu Lys Gly Glu Tyr 

    210                 215                 220                 





Asp Ala Ser Lys Lys Lys Lys Lys Cys Lys Asp Tyr Lys Lys Lys Leu 

225                 230                 235                 240 





Ser Met Gln Gln Lys Gln Leu Asp Trp Arg Pro Glu Arg Arg Ala Gly 

                245                 250                 255     





Pro Ser Arg Met Arg His Glu Arg Val Val Ile Ile Lys Asn Met Phe 

            260                 265                 270         





His Pro Met Asp Phe Glu Asp Asp Pro Leu Val Leu Asn Glu Ile Arg 

        275                 280                 285             





Glu Asp Leu Arg Val Glu Cys Ser Lys Phe Gly Gln Ile Arg Lys Leu 

    290                 295                 300                 





Leu Leu Phe Asp Arg His Pro Asp Gly Val Ala Ser Val Ser Phe Arg 

305                 310                 315                 320 





Asp Pro Glu Glu Ala Asp Tyr Cys Ile Gln Thr Leu Asp Gly Arg Trp 

                325                 330                 335     





Phe Gly Gly Arg Gln Ile Thr Ala Gln Ala Trp Asp Gly Thr Thr Asp 

            340                 345                 350         





Tyr Gln Val Glu Glu Thr Ser Arg Glu Arg Glu Glu Arg Leu Arg Gly 

        355                 360                 365             





Trp Glu Ala Phe Leu Asn Ala Pro Glu Ala Asn Arg Gly Leu Arg Arg 

    370                 375                 380                 





Ser Asp Ser Val Ser Ala Ser Glu Arg Ala Gly Pro Ser Arg Ala Arg 

385                 390                 395                 400 





His Phe Ser Glu His Pro Ser Thr Ser Lys Met Asn Ala Gln Glu Thr 

                405                 410                 415     





Ala Thr Gly Met Ala Phe Glu Glu Pro Ile Asp Glu Lys Lys Phe Glu 

            420                 425                 430         





Lys Thr Glu Asp Gly Gly Glu Phe Glu Glu Gly Ala Ser Glu Asn Asn 

        435                 440                 445             





Ala Lys Glu Ser Ser Pro Glu Lys Glu Ala Glu Glu Gly Cys Pro Glu 

    450                 455                 460                 





Lys Glu Ser Glu Glu Gly Cys Pro Lys Arg Gly Phe Glu Gly Ser Cys 

465                 470                 475                 480 





Ser Gln Lys Glu Ser Glu Glu Gly Asn Pro Val Arg Gly Ser Glu Glu 

                485                 490                 495     





Asp Ser Pro Lys Lys Glu Ser Lys Lys Lys Thr Leu Lys Asn Asp Cys 

            500                 505                 510         





Glu Glu Asn Gly Leu Ala Lys Glu Ser Glu Asp Asp Leu Asn Lys Glu 

        515                 520                 525             





Ser Glu Glu Glu Val Gly Pro Thr Lys Glu Ser Glu Glu Asp Asp Ser 

    530                 535                 540                 





Glu Lys Glu Ser Asp Glu Asp Cys Ser Glu Lys Gln Ser Glu Asp Gly 

545                 550                 555                 560 





Ser Glu Arg Glu Phe Glu Glu Asn Gly Leu Glu Lys Asp Leu Asp Glu 

                565                 570                 575     





Glu Gly Ser Glu Lys Glu Leu His Glu Asn Val Leu Asp Lys Glu Leu 

            580                 585                 590         





Glu Glu Asn Asp Ser Glu Asn Ser Glu Phe Glu Asp Asp Gly Ser Glu 

        595                 600                 605             





Lys Val Leu Asp Glu Glu Gly Ser Glu Arg Glu Phe Asp Glu Asp Ser 

    610                 615                 620                 





Asp Glu Lys Glu Glu Glu Glu Asp Thr Tyr Glu Lys Val Phe Asp Asp 

625                 630                 635                 640 





Glu Ser Asp Glu Lys Glu Asp Glu Glu Tyr Ala Asp Glu Lys Gly Leu 

                645                 650                 655     





Glu Ala Ala Asp Lys Lys Ala Glu Glu Gly Asp Ala Asp Glu Lys Leu 

            660                 665                 670         





Phe Glu Glu Ser Asp Asp Lys Glu Asp Glu Asp Ala Asp Gly Lys Glu 

        675                 680                 685             





Val Glu Asp Ala Asp Glu Lys Leu Phe Glu Asp Asp Asp Ser Asn Glu 

    690                 695                 700                 





Lys Leu Phe Asp Glu Glu Glu Asp Ser Ser Glu Lys Leu Phe Asp Asp 

705                 710                 715                 720 





Ser Asp Glu Arg Gly Thr Leu Gly Gly Phe Gly Ser Val Glu Glu Gly 

                725                 730                 735     





Pro Leu Ser Thr Gly Ser Ser Phe Ile Leu Ser Ser Asp Asp Asp Asp 

            740                 745                 750         





Asp Asp Ile 

        755 





<210>  120

<211>  2339

<212>  DNA

<213>  Homo sapiens



<400>  120

cctgtggtcc cgggtttctg cagagtctac ttcagaagcg gaggcactgg gagtccggtt       60



tgggattgcc aggctgtggt tgtgagtctg agcttgtgag cggctgtggc gccccaactc      120



ttcgccagca tatcatcccg gcaggcgata aactacattc agttgagtct gcaagactgg      180



gaggaactgg ggtgataaga aatctattca ctgtcaaggt ttattgaagt caaaatgtcc      240



aaaaaaatca gtggcggttc tgtggtagag atgcaaggag atgaaatgac acgaatcatt      300



tgggaattga ttaaagagaa actcattttt ccctacgtgg aattggatct acatagctat      360



gatttaggca tagagaatcg tgatgccacc aacgaccaag tcaccaagga tgctgcagaa      420



gctataaaga agcataatgt tggcgtcaaa tgtgccacta tcactcctga tgagaagagg      480



gttgaggagt tcaagttgaa acaaatgtgg aaatcaccaa atggcaccat acgaaatatt      540



ctgggtggca cggtcttcag agaagccatt atctgcaaaa atatcccccg gcttgtgagt      600



ggatgggtaa aacctatcat cataggtcgt catgcttatg gggatcaata cagagcaact      660



gattttgttg ttcctgggcc tggaaaagta gagataacct acacaccaag tgacggaacc      720



caaaaggtga catacctggt acataacttt gaagaaggtg gtggtgttgc catggggatg      780



tataatcaag ataagtcaat tgaagatttt gcacacagtt ccttccaaat ggctctgtct      840



aagggttggc ctttgtatct gagcaccaaa aacactattc tgaagaaata tgatgggcgt      900



tttaaagaca tctttcagga gatatatgac aagcagtaca agtcccagtt tgaagctcaa      960



aagatctggt atgagcatag gctcatcgac gacatggtgg cccaagctat gaaatcagag     1020



ggaggcttca tctgggcctg taaaaactat gatggtgacg tgcagtcgga ctctgtggcc     1080



caagggtatg gctctctcgg catgatgacc agcgtgctgg tttgtccaga tggcaagaca     1140



gtagaagcag aggctgccca cgggactgta acccgtcact accgcatgta ccagaaagga     1200



caggagacgt ccaccaatcc cattgcttcc atttttgcct ggaccagagg gttagcccac     1260



agagcaaagc ttgataacaa taaagagctt gccttctttg caaatgcttt ggaagaagtc     1320



tctattgaga caattgaggc tggcttcatg accaaggact tggctgcttg cattaaaggt     1380



ttacccaatg tgcaacgttc tgactacttg aatacatttg agttcatgga taaacttgga     1440



gaaaacttga agatcaaact agctcaggcc aaactttaag ttcatacctg agctaagaag     1500



gataattgtc ttttggtaac taggtctaca ggtttacatt tttctgtgtt acactcaagg     1560



ataaaggcaa aatcaatttt gtaatttgtt tagaagccag agtttatctt ttctataagt     1620



ttacagcctt tttcttatat atacagttat tgccaccttt gtgaacatgg caagggactt     1680



ttttacaatt tttattttat tttctagtac cagcctagga attcggttag tactcatttg     1740



tattcactgt cactttttct catgttctaa ttataaatga ccaaaatcaa gattgctcaa     1800



aagggtaaat gatagccaca gtattgctcc ctaaaatatg cataaagtag aaattcactg     1860



ccttcccctc ctgtccatga ccttgggcac agggaagttc tggtgtcata gatatcccgt     1920



tttgtgaggt agagctgtgc attaaacttg cacatgactg gaacgaagta tgagtgcaac     1980



tcaaatgtgt tgaagatact gcagtcattt ttgtaaagac cttgctgaat gtttccaata     2040



gactaaatac tgtttaggcc gcaggagagt ttggaatccg gaataaatac tacctggagg     2100



tttgtcctct ccatttttct ctttctcctc ctggcctggc ctgaatatta tactactcta     2160



aatagcatat ttcatccaag tgcaataatg taagctgaat cttttttgga cttctgctgg     2220



cctgttttat ttcttttata taaatgtgat ttctcagaaa ttgatattaa acactatctt     2280



atcttctcct gaactgttga ttttaattaa aattaagtgc taattaccaa aaaaaaaaa      2339





<210>  121

<211>  414

<212>  PRT

<213>  Homo sapiens



<400>  121



Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp 

1               5                   10                  15      





Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Phe 

            20                  25                  30          





Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn 

        35                  40                  45              





Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile 

    50                  55                  60                  





Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 

65                  70                  75                  80  





Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn 

                85                  90                  95      





Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile 

            100                 105                 110         





Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Lys Pro Ile 

        115                 120                 125             





Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe 

    130                 135                 140                 





Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp 

145                 150                 155                 160 





Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly 

                165                 170                 175     





Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe 

            180                 185                 190         





Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr 

        195                 200                 205             





Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys 

    210                 215                 220                 





Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu 

225                 230                 235                 240 





Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 

                245                 250                 255     





Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr 

            260                 265                 270         





Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu 

        275                 280                 285             





Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu 

    290                 295                 300                 





Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln 

305                 310                 315                 320 





Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp 

                325                 330                 335     





Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu 

            340                 345                 350         





Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu 

        355                 360                 365             





Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro 

    370                 375                 380                 





Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys 

385                 390                 395                 400 





Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu 

                405                 410                 





<210>  122

<211>  3955

<212>  DNA

<213>  Homo sapiens



<400>  122

gtgcgtaacg cacgggcccg gcggggaaca ccggtccgct gtaacaccgg cccggcgcag       60



aagcgggacg tcggcttcta ggggcccagg ccggcggcgg cgatggcctc ggcagctgtg      120



gagagcttcg tgaccaagca actggacctg ctggagcttg agagagacgc ggaggtggag      180



gagcgcaggt cctggcagga gaacatctct ctgaaagagc tccagagccg aggcgtgtgt      240



ttgctgaagc tgcaggtatc cagccagcgc actgggctgt acggacggct gctggtcacc      300



tttgagccca ggcgatacgg gtccgcggca gctcttccca gtaacagctt tacttctggt      360



gatatcgtgg gcctgtacga tgctgctaat gagggcagtc agctggccac tgggatcttg      420



acccgggtca cccagaagtc ggtcacggtg gcctttgatg agtcccacga tttccagttg      480



agcttggacc gagagaattc ctacagactg ttaaaacttg ccaatgatgt cacttacagg      540



cgactgaaaa aagccctgat tgctctaaag aagtatcatt ctggcccagc ctcctcactc      600



atagaagtgc tctttggcag atctgctccc agtcctgcca gtgaaataca cccgctgaca      660



ttcttcaaca cctgcctgga cacctcccag aaagaagcgg ttttatttgc gctgtctcag      720



aaagaacttg ccatcatcca tggacctcct ggcactggga aaaccacgac tgtggttgag      780



atcattcttc aagctgtgaa acaaggctta aaggttctgt gctgcgcccc ctccaacatc      840



gccgtggaca atctggtgga gcgcctggct ctgtgtaagc agcggattct gcgcctggga      900



caccctgccc gcctcctgga gtccattcag cagcactccc tggatgcggt tttagcgcgg      960



agcgacagtg cccagattgt tgcagatatc aggaaggaca tcgaccaggt ctttgtgaaa     1020



aacaaaaaga cccaggataa gagagagaaa agtaattttc gaaatgaaat taagctgtta     1080



agaaaagaac tgaaggagag ggaagaagca gctatgctcg agagcctcac ttcggcaaac     1140



gtggtccttg caacaaacac aggtgcgtct gccgatggcc ccctgaagtt gctgcccgag     1200



agctacttcg acgtggtggt cattgacgag tgtgcccagg ccctcgaggc gagctgctgg     1260



atccccctgc tgaaggccag aaagtgcatc ctggcgggcg atcacaagca gctgcccccc     1320



accacagtct ctcacaaggc tgcgctggca ggactgtcac tcagcctgat ggaacgcctg     1380



gctgaggagt acggcgcgag ggtggtgcgg acactgacgg tgcagtaccg catgcaccag     1440



gctatcatgc gctgggcctc agacaccatg taccttgggc agctcacagc ccactcttcc     1500



gtggcaaggc acctcctgag ggacctccca ggtgtggctg ccacagaaga gacgggtgtg     1560



cccctgctct tggtggacac cgccggctgc gggctgtttg agctggagga ggaggacgaa     1620



cagtcgaaag ggaaccctgg cgaagtccgc ctcgtcagtt tgcacatcca ggctctggtg     1680



gacgctggtg ttccagcccg tgacattgct gtggtctcgc catacaacct ccaggtggac     1740



ctgctcagac agagccttgt gcacaggcac cctgagcttg aaatcaagtc tgtcgatggc     1800



ttccaaggcc gagagaagga ggccgtgata ctgtccttcg tcagatccaa caggaaaggt     1860



gaagttggtt ttcttgctga ggaccggagg atcaacgtgg ctgtcacccg tgcccgacgc     1920



cacgtggcgg tcatctgtga ctcccgtact gtcaacaacc atgcattttt gaagaccctg     1980



gtggagtatt tcacacagca tggggaagta cgcacggcct ttgagtatct tgacgatatt     2040



gtcccagaaa actattccca tgagaactcc cagggttcca gccacgctgc caccaagccc     2100



cagggacctg ctacgtccac caggaccgga agccagcggc aggagggagg ccaggaggct     2160



gcagcacctg ccagacaggg ccggaagaag ccggctggga agtctctggc ctctgaagct     2220



ccatctcagc ccagcctcaa cggaggcagc ccagagggag tggagagcca agatggcgtg     2280



gaccacttcc gggccatgat agtggagttc atggccagca agaagatgca gttggagttt     2340



cctccttccc tcaattccca cgacaggctg cgggtccacc aaatagccga ggagcacggg     2400



ctgaggcacg acagttccgg ggaagggaag aggaggttca tcactgtgag caagagggcc     2460



ccgcgacccc gagcagccct gggaccccca gcagggaccg gtggcccagc ccctctccag     2520



ccagtgcccc ctacccctgc gcagacagag cagcctccca gggagcagcg tggcccagac     2580



cagcctgatc tgaggacgct gcacctggag agactgcaga gggtcaggag cgcgcagggg     2640



cagcccgcca gcaaggagca gcaggcctca gggcagcaga aacttccaga aaagaaaaag     2700



aaaaaagcca aaggacatcc ggccacagat ctgcccacgg aggaggactt tgaggccctg     2760



gtttctgccg ccgttaaggc tgataacacc tgcggctttg ccaagtgcac agccggcgtc     2820



acaaccctgg gccagttctg ccagctctgc agccgccgct actgcctcag ccaccacctg     2880



cccgagatcc atggctgcgg tgagagggct cgcgcccatg cccggcagag aatcagccgg     2940



gaaggggtcc tctatgccgg cagcgggacc aagaacggat ccctggaccc agccaagagg     3000



gcccagctgc agaggaggct ggataagaag ctgagtgagc tcagcaacca gaggaccagc     3060



cggaggaagg agagggggac gtgaccggcc gcatccttgc acgccccgcg gagctctctc     3120



catggtagcc cagggcgctg gcagaccatg ctccgcctcc accagggcca cagaggagcg     3180



gaggggccta tgggggagga gcggagggcc ctgttgggga aggttgggtt tttggacccc     3240



agggataagc ttttccgatg tcacaatgtg gaggaaagca cctgggggac aacagtgctc     3300



gtgcaggtgg ggcttgggaa atgcacgtcc cttcccctta ctccccgcca aaacccacat     3360



cccagcctct ggatcctggg gaaggttcca gtccctggag aatacccagg gcctcaaact     3420



tgaagtcact cctccaatgt ctgggacttg ccagctcagc ccgttaggat gagggtgctg     3480



agaggaaaca ggaaacaaga ctgcgaatgg cgctcaggca gggagcaggg agtggcgttt     3540



ggcttgcacg ttcccatgtg gccagatgct ggggccactt tccttctgtc tgctggtgac     3600



tgcagtgttc cccctcctcc tcaccacggg gctcctgtga gtctgggggg cacctctttc     3660



tggcctgtgc acctctctct ggcttataaa ggtgcctggc ctgtgccagc ccctccttgt     3720



tgcgcctcac cgtggggacc aggtgagccg gctctcccac gtggttgtcc cgggaaagct     3780



gccccacagc ctcagcatct tcagcactta ccgatccaga gcctcccggc cttctccggt     3840



gtcctgtacc aactcttcta tttaagagaa cctcagatga tgtacctgag cctcagggtt     3900



ttgtttcaga gggatataaa ttatttaaaa attaaatgaa aacgttgcac actga          3955





<210>  123

<211>  993

<212>  PRT

<213>  Homo sapiens



<400>  123



Met Ala Ser Ala Ala Val Glu Ser Phe Val Thr Lys Gln Leu Asp Leu 

1               5                   10                  15      





Leu Glu Leu Glu Arg Asp Ala Glu Val Glu Glu Arg Arg Ser Trp Gln 

            20                  25                  30          





Glu Asn Ile Ser Leu Lys Glu Leu Gln Ser Arg Gly Val Cys Leu Leu 

        35                  40                  45              





Lys Leu Gln Val Ser Ser Gln Arg Thr Gly Leu Tyr Gly Arg Leu Leu 

    50                  55                  60                  





Val Thr Phe Glu Pro Arg Arg Tyr Gly Ser Ala Ala Ala Leu Pro Ser 

65                  70                  75                  80  





Asn Ser Phe Thr Ser Gly Asp Ile Val Gly Leu Tyr Asp Ala Ala Asn 

                85                  90                  95      





Glu Gly Ser Gln Leu Ala Thr Gly Ile Leu Thr Arg Val Thr Gln Lys 

            100                 105                 110         





Ser Val Thr Val Ala Phe Asp Glu Ser His Asp Phe Gln Leu Ser Leu 

        115                 120                 125             





Asp Arg Glu Asn Ser Tyr Arg Leu Leu Lys Leu Ala Asn Asp Val Thr 

    130                 135                 140                 





Tyr Arg Arg Leu Lys Lys Ala Leu Ile Ala Leu Lys Lys Tyr His Ser 

145                 150                 155                 160 





Gly Pro Ala Ser Ser Leu Ile Glu Val Leu Phe Gly Arg Ser Ala Pro 

                165                 170                 175     





Ser Pro Ala Ser Glu Ile His Pro Leu Thr Phe Phe Asn Thr Cys Leu 

            180                 185                 190         





Asp Thr Ser Gln Lys Glu Ala Val Leu Phe Ala Leu Ser Gln Lys Glu 

        195                 200                 205             





Leu Ala Ile Ile His Gly Pro Pro Gly Thr Gly Lys Thr Thr Thr Val 

    210                 215                 220                 





Val Glu Ile Ile Leu Gln Ala Val Lys Gln Gly Leu Lys Val Leu Cys 

225                 230                 235                 240 





Cys Ala Pro Ser Asn Ile Ala Val Asp Asn Leu Val Glu Arg Leu Ala 

                245                 250                 255     





Leu Cys Lys Gln Arg Ile Leu Arg Leu Gly His Pro Ala Arg Leu Leu 

            260                 265                 270         





Glu Ser Ile Gln Gln His Ser Leu Asp Ala Val Leu Ala Arg Ser Asp 

        275                 280                 285             





Ser Ala Gln Ile Val Ala Asp Ile Arg Lys Asp Ile Asp Gln Val Phe 

    290                 295                 300                 





Val Lys Asn Lys Lys Thr Gln Asp Lys Arg Glu Lys Ser Asn Phe Arg 

305                 310                 315                 320 





Asn Glu Ile Lys Leu Leu Arg Lys Glu Leu Lys Glu Arg Glu Glu Ala 

                325                 330                 335     





Ala Met Leu Glu Ser Leu Thr Ser Ala Asn Val Val Leu Ala Thr Asn 

            340                 345                 350         





Thr Gly Ala Ser Ala Asp Gly Pro Leu Lys Leu Leu Pro Glu Ser Tyr 

        355                 360                 365             





Phe Asp Val Val Val Ile Asp Glu Cys Ala Gln Ala Leu Glu Ala Ser 

    370                 375                 380                 





Cys Trp Ile Pro Leu Leu Lys Ala Arg Lys Cys Ile Leu Ala Gly Asp 

385                 390                 395                 400 





His Lys Gln Leu Pro Pro Thr Thr Val Ser His Lys Ala Ala Leu Ala 

                405                 410                 415     





Gly Leu Ser Leu Ser Leu Met Glu Arg Leu Ala Glu Glu Tyr Gly Ala 

            420                 425                 430         





Arg Val Val Arg Thr Leu Thr Val Gln Tyr Arg Met His Gln Ala Ile 

        435                 440                 445             





Met Arg Trp Ala Ser Asp Thr Met Tyr Leu Gly Gln Leu Thr Ala His 

    450                 455                 460                 





Ser Ser Val Ala Arg His Leu Leu Arg Asp Leu Pro Gly Val Ala Ala 

465                 470                 475                 480 





Thr Glu Glu Thr Gly Val Pro Leu Leu Leu Val Asp Thr Ala Gly Cys 

                485                 490                 495     





Gly Leu Phe Glu Leu Glu Glu Glu Asp Glu Gln Ser Lys Gly Asn Pro 

            500                 505                 510         





Gly Glu Val Arg Leu Val Ser Leu His Ile Gln Ala Leu Val Asp Ala 

        515                 520                 525             





Gly Val Pro Ala Arg Asp Ile Ala Val Val Ser Pro Tyr Asn Leu Gln 

    530                 535                 540                 





Val Asp Leu Leu Arg Gln Ser Leu Val His Arg His Pro Glu Leu Glu 

545                 550                 555                 560 





Ile Lys Ser Val Asp Gly Phe Gln Gly Arg Glu Lys Glu Ala Val Ile 

                565                 570                 575     





Leu Ser Phe Val Arg Ser Asn Arg Lys Gly Glu Val Gly Phe Leu Ala 

            580                 585                 590         





Glu Asp Arg Arg Ile Asn Val Ala Val Thr Arg Ala Arg Arg His Val 

        595                 600                 605             





Ala Val Ile Cys Asp Ser Arg Thr Val Asn Asn His Ala Phe Leu Lys 

    610                 615                 620                 





Thr Leu Val Glu Tyr Phe Thr Gln His Gly Glu Val Arg Thr Ala Phe 

625                 630                 635                 640 





Glu Tyr Leu Asp Asp Ile Val Pro Glu Asn Tyr Ser His Glu Asn Ser 

                645                 650                 655     





Gln Gly Ser Ser His Ala Ala Thr Lys Pro Gln Gly Pro Ala Thr Ser 

            660                 665                 670         





Thr Arg Thr Gly Ser Gln Arg Gln Glu Gly Gly Gln Glu Ala Ala Ala 

        675                 680                 685             





Pro Ala Arg Gln Gly Arg Lys Lys Pro Ala Gly Lys Ser Leu Ala Ser 

    690                 695                 700                 





Glu Ala Pro Ser Gln Pro Ser Leu Asn Gly Gly Ser Pro Glu Gly Val 

705                 710                 715                 720 





Glu Ser Gln Asp Gly Val Asp His Phe Arg Ala Met Ile Val Glu Phe 

                725                 730                 735     





Met Ala Ser Lys Lys Met Gln Leu Glu Phe Pro Pro Ser Leu Asn Ser 

            740                 745                 750         





His Asp Arg Leu Arg Val His Gln Ile Ala Glu Glu His Gly Leu Arg 

        755                 760                 765             





His Asp Ser Ser Gly Glu Gly Lys Arg Arg Phe Ile Thr Val Ser Lys 

    770                 775                 780                 





Arg Ala Pro Arg Pro Arg Ala Ala Leu Gly Pro Pro Ala Gly Thr Gly 

785                 790                 795                 800 





Gly Pro Ala Pro Leu Gln Pro Val Pro Pro Thr Pro Ala Gln Thr Glu 

                805                 810                 815     





Gln Pro Pro Arg Glu Gln Arg Gly Pro Asp Gln Pro Asp Leu Arg Thr 

            820                 825                 830         





Leu His Leu Glu Arg Leu Gln Arg Val Arg Ser Ala Gln Gly Gln Pro 

        835                 840                 845             





Ala Ser Lys Glu Gln Gln Ala Ser Gly Gln Gln Lys Leu Pro Glu Lys 

    850                 855                 860                 





Lys Lys Lys Lys Ala Lys Gly His Pro Ala Thr Asp Leu Pro Thr Glu 

865                 870                 875                 880 





Glu Asp Phe Glu Ala Leu Val Ser Ala Ala Val Lys Ala Asp Asn Thr 

                885                 890                 895     





Cys Gly Phe Ala Lys Cys Thr Ala Gly Val Thr Thr Leu Gly Gln Phe 

            900                 905                 910         





Cys Gln Leu Cys Ser Arg Arg Tyr Cys Leu Ser His His Leu Pro Glu 

        915                 920                 925             





Ile His Gly Cys Gly Glu Arg Ala Arg Ala His Ala Arg Gln Arg Ile 

    930                 935                 940                 





Ser Arg Glu Gly Val Leu Tyr Ala Gly Ser Gly Thr Lys Asn Gly Ser 

945                 950                 955                 960 





Leu Asp Pro Ala Lys Arg Ala Gln Leu Gln Arg Arg Leu Asp Lys Lys 

                965                 970                 975     





Leu Ser Glu Leu Ser Asn Gln Arg Thr Ser Arg Arg Lys Glu Arg Gly 

            980                 985                 990         





Thr 

    





<210>  124

<211>  2086

<212>  DNA

<213>  Homo sapiens



<400>  124

cctgaacgcc catcaagccc atggcccttg tgatccaggt ggggaaacta aggcccagag       60



aagtgaggac cccgcagact atcaatccca gtctcttccc ctcactccct gtgaagctct      120



ccagcatcat cgaggtccca tcaggtgggg aaagatgctg ttccaggcgc acactagtct      180



acaaggccag agctttctgg aagggggcac ccttgccctg ttggatgaat aggcacctct      240



ggaagagcca actgtgtgag atggtgcagc ccagtggtgg cccggcagca gatcaggacg      300



tactgggcga agagtctcct ctggggaagc cagccatgct gcacctgcct tcagaacagg      360



gcgctcctga gaccctccag cgctgcctgg aggagaatca agagctccga gatgccatcc      420



ggcagagcaa ccagattctg cgggagcgct gcgaggagct tctgcatttc caagccagcc      480



agagggagga gaaggagttc ctcatgtgca agttccagga ggccaggaaa ctggtggaga      540



gactcggcct ggagaagctc gatctgaaga ggcagaagga gcaggctctg cgggaggtgg      600



agcacctgaa gagatgccag cagcagatgg ctgaggacaa ggcctctgtg aaagcccagg      660



tgacgtcctt gctcggggag ctgcaggaga gccagagtcg cttggaggct gccactaagg      720



aatgccaggc tctggagggt cgggcccggg cggccagcga gcaggcgcgg cagctggaga      780



gtgagcgcga ggcgctgcag cagcagcaca gcgtgcaggt ggaccagctg cgcatgcagg      840



gccagagcgt ggaggccgcg ctccgcatgg agcgccaggc cgcctcggag gagaagagga      900



agctggccca gttgcaggtg gcctatcacc agctcttcca agaatacgac aaccacatca      960



agagcagcgt ggtgggcagt gagcggaagc gaggaatgca gctggaagat ctcaaacagc     1020



agctccagca ggccgaggag gccctggtgg ccaaacagga ggtgatcgat aagctgaagg     1080



aggaggccga gcagcacaag attgtgatgg agaccgttcc ggtgctgaag gcccaggcgg     1140



atatctacaa ggcggacttc caggctgaga ggcaggcccg ggagaagctg gccgagaaga     1200



aggagctcct gcaggagcag ctggagcagc tgcagaggga gtacagcaaa ctgaaggcca     1260



gctgtcagga gtcggccagg atcgaggaca tgaggaagcg gcatgtcgag gtctcccagg     1320



cccccttgcc ccccgcccct gcctacctct cctctcccct ggccctgccc agccagagga     1380



ggagcccccc cgaggagcca cctgacttct gctgtcccaa gtgccagtat caggcccctg     1440



atatggacac cctgcagata catgtcatgg agtgcattga gtagggccgg ccagtgcaag     1500



gccactgcct gccgaggacg tgcccgggac cgtgcagtct gcgctttcct ctcccgcctg     1560



cctagcccag gatgaagggc tgggtggcca caactgggat gccacctgga gccccaccca     1620



ggagctggcc gcggcacctt acgcttcagc tgttgatccg ctggtcccct cttttggggt     1680



agatgcggcc ccgatcaggc ctgactcgct gctctttttg ttcccttctg tctgctcgaa     1740



ccacttgcct cgggctaatc cctccctctt cctccacccg gcactgggga agtcaagaat     1800



ggggcctggg gctctcaggg agaactgctt cccctggcag agctgggtgg cagctcttcc     1860



tcccaccgga caccgacccg cccgctgctg tgccctggga gtgctgccct cttaccatgc     1920



acacgggtgc tctccttttg ggctgcatgc tattccattt tgcagccaga ccgatgtgta     1980



tttaaccagt cactattgat ggacatttgg gttgtttccc atctttttgt taccataaat     2040



aatggcatag taaaaatcct tgtgcattaa aaaaaaaaaa aaaaaa                    2086





<210>  125

<211>  487

<212>  PRT

<213>  Homo sapiens



<400>  125



Met Ala Leu Val Ile Gln Val Gly Lys Leu Arg Pro Arg Glu Val Arg 

1               5                   10                  15      





Thr Pro Gln Thr Ile Asn Pro Ser Leu Phe Pro Ser Leu Pro Val Lys 

            20                  25                  30          





Leu Ser Ser Ile Ile Glu Val Pro Ser Gly Gly Glu Arg Cys Cys Ser 

        35                  40                  45              





Arg Arg Thr Leu Val Tyr Lys Ala Arg Ala Phe Trp Lys Gly Ala Pro 

    50                  55                  60                  





Leu Pro Cys Trp Met Asn Arg His Leu Trp Lys Ser Gln Leu Cys Glu 

65                  70                  75                  80  





Met Val Gln Pro Ser Gly Gly Pro Ala Ala Asp Gln Asp Val Leu Gly 

                85                  90                  95      





Glu Glu Ser Pro Leu Gly Lys Pro Ala Met Leu His Leu Pro Ser Glu 

            100                 105                 110         





Gln Gly Ala Pro Glu Thr Leu Gln Arg Cys Leu Glu Glu Asn Gln Glu 

        115                 120                 125             





Leu Arg Asp Ala Ile Arg Gln Ser Asn Gln Ile Leu Arg Glu Arg Cys 

    130                 135                 140                 





Glu Glu Leu Leu His Phe Gln Ala Ser Gln Arg Glu Glu Lys Glu Phe 

145                 150                 155                 160 





Leu Met Cys Lys Phe Gln Glu Ala Arg Lys Leu Val Glu Arg Leu Gly 

                165                 170                 175     





Leu Glu Lys Leu Asp Leu Lys Arg Gln Lys Glu Gln Ala Leu Arg Glu 

            180                 185                 190         





Val Glu His Leu Lys Arg Cys Gln Gln Gln Met Ala Glu Asp Lys Ala 

        195                 200                 205             





Ser Val Lys Ala Gln Val Thr Ser Leu Leu Gly Glu Leu Gln Glu Ser 

    210                 215                 220                 





Gln Ser Arg Leu Glu Ala Ala Thr Lys Glu Cys Gln Ala Leu Glu Gly 

225                 230                 235                 240 





Arg Ala Arg Ala Ala Ser Glu Gln Ala Arg Gln Leu Glu Ser Glu Arg 

                245                 250                 255     





Glu Ala Leu Gln Gln Gln His Ser Val Gln Val Asp Gln Leu Arg Met 

            260                 265                 270         





Gln Gly Gln Ser Val Glu Ala Ala Leu Arg Met Glu Arg Gln Ala Ala 

        275                 280                 285             





Ser Glu Glu Lys Arg Lys Leu Ala Gln Leu Gln Val Ala Tyr His Gln 

    290                 295                 300                 





Leu Phe Gln Glu Tyr Asp Asn His Ile Lys Ser Ser Val Val Gly Ser 

305                 310                 315                 320 





Glu Arg Lys Arg Gly Met Gln Leu Glu Asp Leu Lys Gln Gln Leu Gln 

                325                 330                 335     





Gln Ala Glu Glu Ala Leu Val Ala Lys Gln Glu Val Ile Asp Lys Leu 

            340                 345                 350         





Lys Glu Glu Ala Glu Gln His Lys Ile Val Met Glu Thr Val Pro Val 

        355                 360                 365             





Leu Lys Ala Gln Ala Asp Ile Tyr Lys Ala Asp Phe Gln Ala Glu Arg 

    370                 375                 380                 





Gln Ala Arg Glu Lys Leu Ala Glu Lys Lys Glu Leu Leu Gln Glu Gln 

385                 390                 395                 400 





Leu Glu Gln Leu Gln Arg Glu Tyr Ser Lys Leu Lys Ala Ser Cys Gln 

                405                 410                 415     





Glu Ser Ala Arg Ile Glu Asp Met Arg Lys Arg His Val Glu Val Ser 

            420                 425                 430         





Gln Ala Pro Leu Pro Pro Ala Pro Ala Tyr Leu Ser Ser Pro Leu Ala 

        435                 440                 445             





Leu Pro Ser Gln Arg Arg Ser Pro Pro Glu Glu Pro Pro Asp Phe Cys 

    450                 455                 460                 





Cys Pro Lys Cys Gln Tyr Gln Ala Pro Asp Met Asp Thr Leu Gln Ile 

465                 470                 475                 480 





His Val Met Glu Cys Ile Glu 

                485         





<210>  126

<211>  2279

<212>  DNA

<213>  Homo sapiens



<400>  126

gattcctccc ccggagaggg cggggcggcc gagcgccccg aggctagacg ccgccgtccg       60



agagacgagg gggcgtgtag gcggtgacgc cctgcaaagt ggccggcgtg cttatcatta      120



ccgagcttcc gcgggcctgc agagcctggc ggactcagac ttctctccgg agcgggatgc      180



ggccctaccg cggcctcaca cttctcgccg gcttcccgag ttctcggggg cggggcttgt      240



gtttttactt ccggatccca cagctatgac accggaagcc ggaagcgtgg tagggaaggg      300



cgaccgcgaa actgggactt tctcggagcg ccggggccct accagcgttc acagtccgcc      360



gctcccaccc ttctcacgtc tgacggactc tgctgacagc ccttgccctg ttggatgaat      420



aggcacctct ggaagagcca actgtgtgag atggtgcagc ccagtggtgg cccggcagca      480



gatcaggacg tactgggcga agagtctcct ctggggaagc cagccatgct gcacctgcct      540



tcagaacagg gcgctcctga gaccctccag cgctgcctgg aggagaatca agagctccga      600



gatgccatcc ggcagagcaa ccagattctg cgggagcgct gcgaggagct tctgcatttc      660



caagccagcc agagggagga gaaggagttc ctcatgtgca agttccagga ggccaggaaa      720



ctggtggaga gactcggcct ggagaagctc gatctgaaga ggcagaagga gcaggctctg      780



cgggaggtgg agcacctgaa gagatgccag cagcagatgg ctgaggacaa ggcctctgtg      840



aaagcccagg tgacgtcctt gctcggggag ctgcaggaga gccagagtcg cttggaggct      900



gccactaagg aatgccaggc tctggagggt cgggcccggg cggccagcga gcaggcgcgg      960



cagctggaga gtgagcgcga ggcgctgcag cagcagcaca gcgtgcaggt ggaccagctg     1020



cgcatgcagg gccagagcgt ggaggccgcg ctccgcatgg agcgccaggc cgcctcggag     1080



gagaagagga agctggccca gttgcaggtg gcctatcacc agctcttcca agaatacgac     1140



aaccacatca agagcagcgt ggtgggcagt gagcggaagc gaggaatgca gctggaagat     1200



ctcaaacagc agctccagca ggccgaggag gccctggtgg ccaaacagga ggtgatcgat     1260



aagctgaagg aggaggccga gcagcacaag attgtgatgg agaccgttcc ggtgctgaag     1320



gcccaggcgg atatctacaa ggcggacttc caggctgaga ggcaggcccg ggagaagctg     1380



gccgagaaga aggagctcct gcaggagcag ctggagcagc tgcagaggga gtacagcaaa     1440



ctgaaggcca gctgtcagga gtcggccagg atcgaggaca tgaggaagcg gcatgtcgag     1500



gtctcccagg cccccttgcc ccccgcccct gcctacctct cctctcccct ggccctgccc     1560



agccagagga ggagcccccc cgaggagcca cctgacttct gctgtcccaa gtgccagtat     1620



caggcccctg atatggacac cctgcagata catgtcatgg agtgcattga gtagggccgg     1680



ccagtgcaag gccactgcct gccgaggacg tgcccgggac cgtgcagtct gcgctttcct     1740



ctcccgcctg cctagcccag gatgaagggc tgggtggcca caactgggat gccacctgga     1800



gccccaccca ggagctggcc gcggcacctt acgcttcagc tgttgatccg ctggtcccct     1860



cttttggggt agatgcggcc ccgatcaggc ctgactcgct gctctttttg ttcccttctg     1920



tctgctcgaa ccacttgcct cgggctaatc cctccctctt cctccacccg gcactgggga     1980



agtcaagaat ggggcctggg gctctcaggg agaactgctt cccctggcag agctgggtgg     2040



cagctcttcc tcccaccgga caccgacccg cccgctgctg tgccctggga gtgctgccct     2100



cttaccatgc acacgggtgc tctccttttg ggctgcatgc tattccattt tgcagccaga     2160



ccgatgtgta tttaaccagt cactattgat ggacatttgg gttgtttccc atctttttgt     2220



taccataaat aatggcatag taaaaatcct tgtgcattaa aaaaaaaaaa aaaaaaaaa      2279





<210>  127

<211>  419

<212>  PRT

<213>  Homo sapiens



<400>  127



Met Asn Arg His Leu Trp Lys Ser Gln Leu Cys Glu Met Val Gln Pro 

1               5                   10                  15      





Ser Gly Gly Pro Ala Ala Asp Gln Asp Val Leu Gly Glu Glu Ser Pro 

            20                  25                  30          





Leu Gly Lys Pro Ala Met Leu His Leu Pro Ser Glu Gln Gly Ala Pro 

        35                  40                  45              





Glu Thr Leu Gln Arg Cys Leu Glu Glu Asn Gln Glu Leu Arg Asp Ala 

    50                  55                  60                  





Ile Arg Gln Ser Asn Gln Ile Leu Arg Glu Arg Cys Glu Glu Leu Leu 

65                  70                  75                  80  





His Phe Gln Ala Ser Gln Arg Glu Glu Lys Glu Phe Leu Met Cys Lys 

                85                  90                  95      





Phe Gln Glu Ala Arg Lys Leu Val Glu Arg Leu Gly Leu Glu Lys Leu 

            100                 105                 110         





Asp Leu Lys Arg Gln Lys Glu Gln Ala Leu Arg Glu Val Glu His Leu 

        115                 120                 125             





Lys Arg Cys Gln Gln Gln Met Ala Glu Asp Lys Ala Ser Val Lys Ala 

    130                 135                 140                 





Gln Val Thr Ser Leu Leu Gly Glu Leu Gln Glu Ser Gln Ser Arg Leu 

145                 150                 155                 160 





Glu Ala Ala Thr Lys Glu Cys Gln Ala Leu Glu Gly Arg Ala Arg Ala 

                165                 170                 175     





Ala Ser Glu Gln Ala Arg Gln Leu Glu Ser Glu Arg Glu Ala Leu Gln 

            180                 185                 190         





Gln Gln His Ser Val Gln Val Asp Gln Leu Arg Met Gln Gly Gln Ser 

        195                 200                 205             





Val Glu Ala Ala Leu Arg Met Glu Arg Gln Ala Ala Ser Glu Glu Lys 

    210                 215                 220                 





Arg Lys Leu Ala Gln Leu Gln Val Ala Tyr His Gln Leu Phe Gln Glu 

225                 230                 235                 240 





Tyr Asp Asn His Ile Lys Ser Ser Val Val Gly Ser Glu Arg Lys Arg 

                245                 250                 255     





Gly Met Gln Leu Glu Asp Leu Lys Gln Gln Leu Gln Gln Ala Glu Glu 

            260                 265                 270         





Ala Leu Val Ala Lys Gln Glu Val Ile Asp Lys Leu Lys Glu Glu Ala 

        275                 280                 285             





Glu Gln His Lys Ile Val Met Glu Thr Val Pro Val Leu Lys Ala Gln 

    290                 295                 300                 





Ala Asp Ile Tyr Lys Ala Asp Phe Gln Ala Glu Arg Gln Ala Arg Glu 

305                 310                 315                 320 





Lys Leu Ala Glu Lys Lys Glu Leu Leu Gln Glu Gln Leu Glu Gln Leu 

                325                 330                 335     





Gln Arg Glu Tyr Ser Lys Leu Lys Ala Ser Cys Gln Glu Ser Ala Arg 

            340                 345                 350         





Ile Glu Asp Met Arg Lys Arg His Val Glu Val Ser Gln Ala Pro Leu 

        355                 360                 365             





Pro Pro Ala Pro Ala Tyr Leu Ser Ser Pro Leu Ala Leu Pro Ser Gln 

    370                 375                 380                 





Arg Arg Ser Pro Pro Glu Glu Pro Pro Asp Phe Cys Cys Pro Lys Cys 

385                 390                 395                 400 





Gln Tyr Gln Ala Pro Asp Met Asp Thr Leu Gln Ile His Val Met Glu 

                405                 410                 415     





Cys Ile Glu 

            





<210>  128

<211>  1982

<212>  DNA

<213>  Homo sapiens



<400>  128

gattcctccc ccggagaggg cggggcggcc gagcgccccg aggctagacg ccgccgtccg       60



agagacgagg gggcgtgtag gcggtgacgc cctgcaaagt ggccggcgtg cttatcatta      120



ccgagcttcc gcgggcctgc agagcctggc ggactcagac ttctctccgg agcgggatgc      180



ggccctaccg cggcctcaca cttctcgccg gcttcccgag ttctcggggg cggggcttgt      240



gtttttactt ccggatccca cagctatgac accggaagcc ggaagcgtgg tagggaaggg      300



cgaccgcgaa actgggactt tctcggagcg ccggggccct accagcgttc acagtccgcc      360



gctcccaccc ttctcacgtc tgacggactc tgctgacagc ccttgccctg ttggatgaat      420



aggcacctct ggaagagcca actgtgtgag atggtgcagc ccagtggtgg cccggcagca      480



gatcaggacg tactgggcga agagtctcct ctggggaagc cagccatgct gcacctgcct      540



tcagaacagg gcgctcctga gaccctccag cgctgcctgg aggagaatca agagctccga      600



gatgccatcc ggcagagcaa ccagattctg cgggagcgct gcgaggagct tctgcatttc      660



caagccagcc agagggagga gaaggagttc ctcatgtgca agttccagga ggccaggaaa      720



ctggtggaga gactcggcct ggagaagctc gatctgaaga ggcagaagga gcaggctctg      780



cgggaggtgg agcacctgaa gagatgccag cagcagatgg ctgaggacaa ggcctctgtg      840



aaagcccagg tgacgtcctt gctcggggag ctgcaggaga gccagagtcg cttggaggct      900



gccactaagg aatgccaggc tctggagggt cggaggaagc tggcccagtt gcaggtggcc      960



tatcaccagc tcttccaaga atacgacaac cacatcaaga gcagcgtggt gggcagtgag     1020



cggaagcgag cggatatcta caaggcggac ttccaggctg agaggcaggc ccgggagaag     1080



ctggccgaga agaaggagct cctgcaggag cagctggagc agctgcagag ggagtacagc     1140



aaactgaagg ccagctgtca ggagtcggcc aggatcgagg acatgaggaa gcggcatgtc     1200



gaggtctccc aggccccctt gccccccgcc cctgcctacc tctcctctcc cctggccctg     1260



cccagccaga ggaggagccc ccccgaggag ccacctgact tctgctgtcc caagtgccag     1320



tatcaggccc ctgatatgga caccctgcag atacatgtca tggagtgcat tgagtagggc     1380



cggccagtgc aaggccactg cctgccgagg acgtgcccgg gaccgtgcag tctgcgcttt     1440



cctctcccgc ctgcctagcc caggatgaag ggctgggtgg ccacaactgg gatgccacct     1500



ggagccccac ccaggagctg gccgcggcac cttacgcttc agctgttgat ccgctggtcc     1560



cctcttttgg ggtagatgcg gccccgatca ggcctgactc gctgctcttt ttgttccctt     1620



ctgtctgctc gaaccacttg cctcgggcta atccctccct cttcctccac ccggcactgg     1680



ggaagtcaag aatggggcct ggggctctca gggagaactg cttcccctgg cagagctggg     1740



tggcagctct tcctcccacc ggacaccgac ccgcccgctg ctgtgccctg ggagtgctgc     1800



cctcttacca tgcacacggg tgctctcctt ttgggctgca tgctattcca ttttgcagcc     1860



agaccgatgt gtatttaacc agtcactatt gatggacatt tgggttgttt cccatctttt     1920



tgttaccata aataatggca tagtaaaaat ccttgtgcat taaaaaaaaa aaaaaaaaaa     1980



aa                                                                    1982





<210>  129

<211>  320

<212>  PRT

<213>  Homo sapiens



<400>  129



Met Asn Arg His Leu Trp Lys Ser Gln Leu Cys Glu Met Val Gln Pro 

1               5                   10                  15      





Ser Gly Gly Pro Ala Ala Asp Gln Asp Val Leu Gly Glu Glu Ser Pro 

            20                  25                  30          





Leu Gly Lys Pro Ala Met Leu His Leu Pro Ser Glu Gln Gly Ala Pro 

        35                  40                  45              





Glu Thr Leu Gln Arg Cys Leu Glu Glu Asn Gln Glu Leu Arg Asp Ala 

    50                  55                  60                  





Ile Arg Gln Ser Asn Gln Ile Leu Arg Glu Arg Cys Glu Glu Leu Leu 

65                  70                  75                  80  





His Phe Gln Ala Ser Gln Arg Glu Glu Lys Glu Phe Leu Met Cys Lys 

                85                  90                  95      





Phe Gln Glu Ala Arg Lys Leu Val Glu Arg Leu Gly Leu Glu Lys Leu 

            100                 105                 110         





Asp Leu Lys Arg Gln Lys Glu Gln Ala Leu Arg Glu Val Glu His Leu 

        115                 120                 125             





Lys Arg Cys Gln Gln Gln Met Ala Glu Asp Lys Ala Ser Val Lys Ala 

    130                 135                 140                 





Gln Val Thr Ser Leu Leu Gly Glu Leu Gln Glu Ser Gln Ser Arg Leu 

145                 150                 155                 160 





Glu Ala Ala Thr Lys Glu Cys Gln Ala Leu Glu Gly Arg Arg Lys Leu 

                165                 170                 175     





Ala Gln Leu Gln Val Ala Tyr His Gln Leu Phe Gln Glu Tyr Asp Asn 

            180                 185                 190         





His Ile Lys Ser Ser Val Val Gly Ser Glu Arg Lys Arg Ala Asp Ile 

        195                 200                 205             





Tyr Lys Ala Asp Phe Gln Ala Glu Arg Gln Ala Arg Glu Lys Leu Ala 

    210                 215                 220                 





Glu Lys Lys Glu Leu Leu Gln Glu Gln Leu Glu Gln Leu Gln Arg Glu 

225                 230                 235                 240 





Tyr Ser Lys Leu Lys Ala Ser Cys Gln Glu Ser Ala Arg Ile Glu Asp 

                245                 250                 255     





Met Arg Lys Arg His Val Glu Val Ser Gln Ala Pro Leu Pro Pro Ala 

            260                 265                 270         





Pro Ala Tyr Leu Ser Ser Pro Leu Ala Leu Pro Ser Gln Arg Arg Ser 

        275                 280                 285             





Pro Pro Glu Glu Pro Pro Asp Phe Cys Cys Pro Lys Cys Gln Tyr Gln 

    290                 295                 300                 





Ala Pro Asp Met Asp Thr Leu Gln Ile His Val Met Glu Cys Ile Glu 

305                 310                 315                 320 





<210>  130

<211>  2120

<212>  DNA

<213>  Homo sapiens



<400>  130

agcccgttcc tgctccgcgc ttctggagca ctggccaagg cgggccgatt caggacccag       60



gttacttggg cggcgagctg gactgtttct actcctccct cctcctccac tgcggggtct      120



gaccctactc cttgtgtgag gactcctcta gttcagagac atattctgtt caccaaactt      180



gactgcgctc tatcgaggtc gttaaattct tcggaaatgc ctcacatata gtttggcagc      240



tagcccttgc cctgttggat gaataggcac ctctggaaga gccaactgtg tgagatggtg      300



cagcccagtg gtggcccggc agcagatcag gacgtactgg gcgaagagtc tcctctgggg      360



aagccagcca tgctgcacct gccttcagaa cagggcgctc ctgagaccct ccagcgctgc      420



ctggaggaga atcaagagct ccgagatgcc atccggcaga gcaaccagat tctgcgggag      480



cgctgcgagg agcttctgca tttccaagcc agccagaggg aggagaagga gttcctcatg      540



tgcaagttcc aggaggccag gaaactggtg gagagactcg gcctggagaa gctcgatctg      600



aagaggcaga aggagcaggc tctgcgggag gtggagcacc tgaagagatg ccagcagcag      660



atggctgagg acaaggcctc tgtgaaagcc caggtgacgt ccttgctcgg ggagctgcag      720



gagagccaga gtcgcttgga ggctgccact aaggaatgcc aggctctgga gggtcgggcc      780



cgggcggcca gcgagcaggc gcggcagctg gagagtgagc gcgaggcgct gcagcagcag      840



cacagcgtgc aggtggacca gctgcgcatg cagggccaga gcgtggaggc cgcgctccgc      900



atggagcgcc aggccgcctc ggaggagaag aggaagctgg cccagttgca ggtggcctat      960



caccagctct tccaagaata cgacaaccac atcaagagca gcgtggtggg cagtgagcgg     1020



aagcgaggaa tgcagctgga agatctcaaa cagcagctcc agcaggccga ggaggccctg     1080



gtggccaaac aggaggtgat cgataagctg aaggaggagg ccgagcagca caagattgtg     1140



atggagaccg ttccggtgct gaaggcccag gcggatatct acaaggcgga cttccaggct     1200



gagaggcagg cccgggagaa gctggccgag aagaaggagc tcctgcagga gcagctggag     1260



cagctgcaga gggagtacag caaactgaag gccagctgtc aggagtcggc caggatcgag     1320



gacatgagga agcggcatgt cgaggtctcc caggccccct tgccccccgc ccctgcctac     1380



ctctcctctc ccctggccct gcccagccag aggaggagcc cccccgagga gccacctgac     1440



ttctgctgtc ccaagtgcca gtatcaggcc cctgatatgg acaccctgca gatacatgtc     1500



atggagtgca ttgagtaggg ccggccagtg caaggccact gcctgccgag gacgtgcccg     1560



ggaccgtgca gtctgcgctt tcctctcccg cctgcctagc ccaggatgaa gggctgggtg     1620



gccacaactg ggatgccacc tggagcccca cccaggagct ggccgcggca ccttacgctt     1680



cagctgttga tccgctggtc ccctcttttg gggtagatgc ggccccgatc aggcctgact     1740



cgctgctctt tttgttccct tctgtctgct cgaaccactt gcctcgggct aatccctccc     1800



tcttcctcca cccggcactg gggaagtcaa gaatggggcc tggggctctc agggagaact     1860



gcttcccctg gcagagctgg gtggcagctc ttcctcccac cggacaccga cccgcccgct     1920



gctgtgccct gggagtgctg ccctcttacc atgcacacgg gtgctctcct tttgggctgc     1980



atgctattcc attttgcagc cagaccgatg tgtatttaac cagtcactat tgatggacat     2040



ttgggttgtt tcccatcttt ttgttaccat aaataatggc atagtaaaaa tccttgtgca     2100



ttaaaaaaaa aaaaaaaaaa                                                 2120





<210>  131

<211>  419

<212>  PRT

<213>  Homo sapiens



<400>  131



Met Asn Arg His Leu Trp Lys Ser Gln Leu Cys Glu Met Val Gln Pro 

1               5                   10                  15      





Ser Gly Gly Pro Ala Ala Asp Gln Asp Val Leu Gly Glu Glu Ser Pro 

            20                  25                  30          





Leu Gly Lys Pro Ala Met Leu His Leu Pro Ser Glu Gln Gly Ala Pro 

        35                  40                  45              





Glu Thr Leu Gln Arg Cys Leu Glu Glu Asn Gln Glu Leu Arg Asp Ala 

    50                  55                  60                  





Ile Arg Gln Ser Asn Gln Ile Leu Arg Glu Arg Cys Glu Glu Leu Leu 

65                  70                  75                  80  





His Phe Gln Ala Ser Gln Arg Glu Glu Lys Glu Phe Leu Met Cys Lys 

                85                  90                  95      





Phe Gln Glu Ala Arg Lys Leu Val Glu Arg Leu Gly Leu Glu Lys Leu 

            100                 105                 110         





Asp Leu Lys Arg Gln Lys Glu Gln Ala Leu Arg Glu Val Glu His Leu 

        115                 120                 125             





Lys Arg Cys Gln Gln Gln Met Ala Glu Asp Lys Ala Ser Val Lys Ala 

    130                 135                 140                 





Gln Val Thr Ser Leu Leu Gly Glu Leu Gln Glu Ser Gln Ser Arg Leu 

145                 150                 155                 160 





Glu Ala Ala Thr Lys Glu Cys Gln Ala Leu Glu Gly Arg Ala Arg Ala 

                165                 170                 175     





Ala Ser Glu Gln Ala Arg Gln Leu Glu Ser Glu Arg Glu Ala Leu Gln 

            180                 185                 190         





Gln Gln His Ser Val Gln Val Asp Gln Leu Arg Met Gln Gly Gln Ser 

        195                 200                 205             





Val Glu Ala Ala Leu Arg Met Glu Arg Gln Ala Ala Ser Glu Glu Lys 

    210                 215                 220                 





Arg Lys Leu Ala Gln Leu Gln Val Ala Tyr His Gln Leu Phe Gln Glu 

225                 230                 235                 240 





Tyr Asp Asn His Ile Lys Ser Ser Val Val Gly Ser Glu Arg Lys Arg 

                245                 250                 255     





Gly Met Gln Leu Glu Asp Leu Lys Gln Gln Leu Gln Gln Ala Glu Glu 

            260                 265                 270         





Ala Leu Val Ala Lys Gln Glu Val Ile Asp Lys Leu Lys Glu Glu Ala 

        275                 280                 285             





Glu Gln His Lys Ile Val Met Glu Thr Val Pro Val Leu Lys Ala Gln 

    290                 295                 300                 





Ala Asp Ile Tyr Lys Ala Asp Phe Gln Ala Glu Arg Gln Ala Arg Glu 

305                 310                 315                 320 





Lys Leu Ala Glu Lys Lys Glu Leu Leu Gln Glu Gln Leu Glu Gln Leu 

                325                 330                 335     





Gln Arg Glu Tyr Ser Lys Leu Lys Ala Ser Cys Gln Glu Ser Ala Arg 

            340                 345                 350         





Ile Glu Asp Met Arg Lys Arg His Val Glu Val Ser Gln Ala Pro Leu 

        355                 360                 365             





Pro Pro Ala Pro Ala Tyr Leu Ser Ser Pro Leu Ala Leu Pro Ser Gln 

    370                 375                 380                 





Arg Arg Ser Pro Pro Glu Glu Pro Pro Asp Phe Cys Cys Pro Lys Cys 

385                 390                 395                 400 





Gln Tyr Gln Ala Pro Asp Met Asp Thr Leu Gln Ile His Val Met Glu 

                405                 410                 415     





Cys Ile Glu 

            





<210>  132

<211>  3462

<212>  DNA

<213>  Homo sapiens



<400>  132

agcgcgcgga agaaaaacca gcaagaaggc ggcgggggaa gatggcggtc ctggggtaga       60



gtttgcaagc tttctgacta ggctagtcga gtaactattc gggtcatggc gtcaaactca      120



actaagtctt tcctggcaga tgccggctat ggcgaacagg aactggatgc caactctgcc      180



cttatggaat tggacaaagg cctaagatct ggcaaacttg gtgaacagtg tgaagcagtt      240



gttcgctttc ccagactttt tcagaagtat ccattcccta ttcttatcaa ttctgcattc      300



ctaaagttag ctgatgtttt cagagttgga aataatttcc tgaggctatg tgttcttaaa      360



gttacccaac aaagtgagaa acatttggag aagattctaa atgtggatga atttgtgaag      420



agaatttttt ctgtgattca tagtaatgat cctgtggcaa gagccatcac cctccggatg      480



ttgggaagtc tggcatcaat aattcctgag aggaagaatg ctcatcatag tattcgtcag      540



agtttagatt cacatgataa tgtagaagtt gaagctgctg tttttgctgc tgcaaacttc      600



tctgcacagt caaaggattt tgctgtagga atctgtaaca aaatcagtga aatgattcaa      660



ggtttagcga caccagtaga cttgaagcta aaattgatac ccattctaca gcacatgcac      720



catgatgcaa tcttggcttc cagtgctcgt cagcttttac aacagctggt cacatcctat      780



ccgtccacca aaatggtgat tgtgtctttg cacactttca ctctgcttgc agcgtcatct      840



ttggttgata cacctaagca gattcagctt ctgttgcagt atttgaagaa tgatcccagg      900



aaggcagtaa agagacttgc tattcaagat ctgaaattac ttgctaataa aacaccacat      960



acttggagta gggagaatat tcaggcactt tgtgagtgtg ccctccagac tccttatgac     1020



agcttaaaac tagggatgtt gtctgtcctt tccacactat cagggaccat cgccatcaaa     1080



cattacttca gtatagttcc aggaaatgtg agttcttctc ccagatcttc tgatttagtc     1140



aaattagccc aagagtgctg ttaccataat aacaggggca ttgcagctca tggagttaga     1200



gtcctaacta atataactgt ttcttgtcaa gaaaaggatc ttttggcact ggaacaagat     1260



gctgtctttg gcctggaatc cctactggta ctttgtagtc aagatgatag tccaggtgct     1320



caggccactt taaagattgc tctaaactgt atggtgaagt tggccaaggg caggccccat     1380



cttagccagt cagtagttga gaccttgttg actcaattgc acagtgctca agacgctgcc     1440



cggattttga tgtgccattg cctggcagcc attgccatgc aactgccggt gctgggtgat     1500



gggatgcttg gtgacctcat ggagctgtac aaggtgattg gacgatcagc cacagacaag     1560



caacaagaac ttctggtgag tttggctact gtgatttttg ttgcaagtca gaaggcattg     1620



tctgtggaaa gtaaggcagt aattaagcag cagcttgaaa gtgtctccaa tggatggact     1680



gtataccgta ttgccagaca ggcttccaga atgggtaatc atgacatggc caaagagctt     1740



tatcagagtt tgctgactca ggttgcctca gaacatttct acttctggct aaatagtttg     1800



aaggagtttt cacatgcaga acagtgtctc actgggttgc aagaggaaaa ttatagttca     1860



gcactttctt gcattgctga atctttaaaa ttctatcaca aagggattgc ttccttaaca     1920



gcagctagta caccactgaa tcctttaagc tttcagtgtg aatttgtaaa actcaggatt     1980



gaccttttac aagccttctc tcaacttatc tgtacttgta atagcctgaa gacaagccca     2040



ccacctgcaa ttgccacaac aattgccatg accttaggaa atgacctcca gaggtgtggt     2100



cgcatctcca atcagatgaa acagtccatg gaagaatttc gaagccttgc ttctcgatat     2160



ggagatcttt accaggcatc ttttgatgct gactcagcaa ctttgaggaa tgttgaacta     2220



cagcagcaga gctgtttact gatatctcat gcaatagaag ccctgatttt ggatccagaa     2280



tcagcaagtt tccaggaata tggatctact ggaacagccc atgctgatag tgaatatgaa     2340



agaagaatga tgtctgtata taatcatgtc ttggaggagg tagaatcact caatcggaaa     2400



tatacccctg tttcttatat gcacacagca tgcctctgca atgccatcat tgctttgctg     2460



aaagttcccc tttctttcca gagatatttt ttccagaaac tacagtctac cagcatcaag     2520



cttgctctgt caccatcgcc ccggaatcct gcagagccca ttgctgtcca gaataaccag     2580



cagctggcgc taaaggtaga gggagtggtt cagcacggat ctaaaccagg actcttccgc     2640



aaaattcagt ctgtctgtct gaatgtttct tccacactgc agagtaaatc tggacaagac     2700



tacaagatac ccattgacaa catgaccaat gagatggagc aaagggttga acctcataat     2760



gattacttca gtactcaatt tctgttgaac tttgctatcc ttggaacaca caacattaca     2820



gtggaatctt ctgtgaaaga tgccaatggt atagtatgga agactggtcc cagaactacc     2880



atatttgtaa aatccctgga agacccttat tcccagcaaa ttcgcttaca acagcagcaa     2940



gcccagcagc cattacagca gcagcagcaa cgcaatgcct acacacggtt ttaaccatgg     3000



aatgaatgca ctgcagactc tcaagagatc aatcaaattg ccagaaacag tttggttttt     3060



catatggaat aagtattaaa gttacagtgt agttcattta ttcattgatt tttgtaatgt     3120



aatattctgg aaaaaatttt gttttcttaa aaattttgtc tgacagctgg gcgtggttgc     3180



tcacgcctgt aatcccagca ctttgggagg ctgaggtggg cggctcacga ggagatcaag     3240



accatcctgg ctaacacagt gaaaccccgt ctccactaaa aaatacaaaa aaattagcca     3300



agcatggtgg caggcgcctg tagtcccagc tacttgggag gctgaggcag gagaatggtg     3360



tgaacctggg aggcggagct tgcagtgagc cgagactgtg ctccagcctg ggcgacagag     3420



cgagactccg tctcaaaaaa ataaataaat acattttgtc tg                        3462





<210>  133

<211>  962

<212>  PRT

<213>  Homo sapiens



<400>  133



Met Ala Ser Asn Ser Thr Lys Ser Phe Leu Ala Asp Ala Gly Tyr Gly 

1               5                   10                  15      





Glu Gln Glu Leu Asp Ala Asn Ser Ala Leu Met Glu Leu Asp Lys Gly 

            20                  25                  30          





Leu Arg Ser Gly Lys Leu Gly Glu Gln Cys Glu Ala Val Val Arg Phe 

        35                  40                  45              





Pro Arg Leu Phe Gln Lys Tyr Pro Phe Pro Ile Leu Ile Asn Ser Ala 

    50                  55                  60                  





Phe Leu Lys Leu Ala Asp Val Phe Arg Val Gly Asn Asn Phe Leu Arg 

65                  70                  75                  80  





Leu Cys Val Leu Lys Val Thr Gln Gln Ser Glu Lys His Leu Glu Lys 

                85                  90                  95      





Ile Leu Asn Val Asp Glu Phe Val Lys Arg Ile Phe Ser Val Ile His 

            100                 105                 110         





Ser Asn Asp Pro Val Ala Arg Ala Ile Thr Leu Arg Met Leu Gly Ser 

        115                 120                 125             





Leu Ala Ser Ile Ile Pro Glu Arg Lys Asn Ala His His Ser Ile Arg 

    130                 135                 140                 





Gln Ser Leu Asp Ser His Asp Asn Val Glu Val Glu Ala Ala Val Phe 

145                 150                 155                 160 





Ala Ala Ala Asn Phe Ser Ala Gln Ser Lys Asp Phe Ala Val Gly Ile 

                165                 170                 175     





Cys Asn Lys Ile Ser Glu Met Ile Gln Gly Leu Ala Thr Pro Val Asp 

            180                 185                 190         





Leu Lys Leu Lys Leu Ile Pro Ile Leu Gln His Met His His Asp Ala 

        195                 200                 205             





Ile Leu Ala Ser Ser Ala Arg Gln Leu Leu Gln Gln Leu Val Thr Ser 

    210                 215                 220                 





Tyr Pro Ser Thr Lys Met Val Ile Val Ser Leu His Thr Phe Thr Leu 

225                 230                 235                 240 





Leu Ala Ala Ser Ser Leu Val Asp Thr Pro Lys Gln Ile Gln Leu Leu 

                245                 250                 255     





Leu Gln Tyr Leu Lys Asn Asp Pro Arg Lys Ala Val Lys Arg Leu Ala 

            260                 265                 270         





Ile Gln Asp Leu Lys Leu Leu Ala Asn Lys Thr Pro His Thr Trp Ser 

        275                 280                 285             





Arg Glu Asn Ile Gln Ala Leu Cys Glu Cys Ala Leu Gln Thr Pro Tyr 

    290                 295                 300                 





Asp Ser Leu Lys Leu Gly Met Leu Ser Val Leu Ser Thr Leu Ser Gly 

305                 310                 315                 320 





Thr Ile Ala Ile Lys His Tyr Phe Ser Ile Val Pro Gly Asn Val Ser 

                325                 330                 335     





Ser Ser Pro Arg Ser Ser Asp Leu Val Lys Leu Ala Gln Glu Cys Cys 

            340                 345                 350         





Tyr His Asn Asn Arg Gly Ile Ala Ala His Gly Val Arg Val Leu Thr 

        355                 360                 365             





Asn Ile Thr Val Ser Cys Gln Glu Lys Asp Leu Leu Ala Leu Glu Gln 

    370                 375                 380                 





Asp Ala Val Phe Gly Leu Glu Ser Leu Leu Val Leu Cys Ser Gln Asp 

385                 390                 395                 400 





Asp Ser Pro Gly Ala Gln Ala Thr Leu Lys Ile Ala Leu Asn Cys Met 

                405                 410                 415     





Val Lys Leu Ala Lys Gly Arg Pro His Leu Ser Gln Ser Val Val Glu 

            420                 425                 430         





Thr Leu Leu Thr Gln Leu His Ser Ala Gln Asp Ala Ala Arg Ile Leu 

        435                 440                 445             





Met Cys His Cys Leu Ala Ala Ile Ala Met Gln Leu Pro Val Leu Gly 

    450                 455                 460                 





Asp Gly Met Leu Gly Asp Leu Met Glu Leu Tyr Lys Val Ile Gly Arg 

465                 470                 475                 480 





Ser Ala Thr Asp Lys Gln Gln Glu Leu Leu Val Ser Leu Ala Thr Val 

                485                 490                 495     





Ile Phe Val Ala Ser Gln Lys Ala Leu Ser Val Glu Ser Lys Ala Val 

            500                 505                 510         





Ile Lys Gln Gln Leu Glu Ser Val Ser Asn Gly Trp Thr Val Tyr Arg 

        515                 520                 525             





Ile Ala Arg Gln Ala Ser Arg Met Gly Asn His Asp Met Ala Lys Glu 

    530                 535                 540                 





Leu Tyr Gln Ser Leu Leu Thr Gln Val Ala Ser Glu His Phe Tyr Phe 

545                 550                 555                 560 





Trp Leu Asn Ser Leu Lys Glu Phe Ser His Ala Glu Gln Cys Leu Thr 

                565                 570                 575     





Gly Leu Gln Glu Glu Asn Tyr Ser Ser Ala Leu Ser Cys Ile Ala Glu 

            580                 585                 590         





Ser Leu Lys Phe Tyr His Lys Gly Ile Ala Ser Leu Thr Ala Ala Ser 

        595                 600                 605             





Thr Pro Leu Asn Pro Leu Ser Phe Gln Cys Glu Phe Val Lys Leu Arg 

    610                 615                 620                 





Ile Asp Leu Leu Gln Ala Phe Ser Gln Leu Ile Cys Thr Cys Asn Ser 

625                 630                 635                 640 





Leu Lys Thr Ser Pro Pro Pro Ala Ile Ala Thr Thr Ile Ala Met Thr 

                645                 650                 655     





Leu Gly Asn Asp Leu Gln Arg Cys Gly Arg Ile Ser Asn Gln Met Lys 

            660                 665                 670         





Gln Ser Met Glu Glu Phe Arg Ser Leu Ala Ser Arg Tyr Gly Asp Leu 

        675                 680                 685             





Tyr Gln Ala Ser Phe Asp Ala Asp Ser Ala Thr Leu Arg Asn Val Glu 

    690                 695                 700                 





Leu Gln Gln Gln Ser Cys Leu Leu Ile Ser His Ala Ile Glu Ala Leu 

705                 710                 715                 720 





Ile Leu Asp Pro Glu Ser Ala Ser Phe Gln Glu Tyr Gly Ser Thr Gly 

                725                 730                 735     





Thr Ala His Ala Asp Ser Glu Tyr Glu Arg Arg Met Met Ser Val Tyr 

            740                 745                 750         





Asn His Val Leu Glu Glu Val Glu Ser Leu Asn Arg Lys Tyr Thr Pro 

        755                 760                 765             





Val Ser Tyr Met His Thr Ala Cys Leu Cys Asn Ala Ile Ile Ala Leu 

    770                 775                 780                 





Leu Lys Val Pro Leu Ser Phe Gln Arg Tyr Phe Phe Gln Lys Leu Gln 

785                 790                 795                 800 





Ser Thr Ser Ile Lys Leu Ala Leu Ser Pro Ser Pro Arg Asn Pro Ala 

                805                 810                 815     





Glu Pro Ile Ala Val Gln Asn Asn Gln Gln Leu Ala Leu Lys Val Glu 

            820                 825                 830         





Gly Val Val Gln His Gly Ser Lys Pro Gly Leu Phe Arg Lys Ile Gln 

        835                 840                 845             





Ser Val Cys Leu Asn Val Ser Ser Thr Leu Gln Ser Lys Ser Gly Gln 

    850                 855                 860                 





Asp Tyr Lys Ile Pro Ile Asp Asn Met Thr Asn Glu Met Glu Gln Arg 

865                 870                 875                 880 





Val Glu Pro His Asn Asp Tyr Phe Ser Thr Gln Phe Leu Leu Asn Phe 

                885                 890                 895     





Ala Ile Leu Gly Thr His Asn Ile Thr Val Glu Ser Ser Val Lys Asp 

            900                 905                 910         





Ala Asn Gly Ile Val Trp Lys Thr Gly Pro Arg Thr Thr Ile Phe Val 

        915                 920                 925             





Lys Ser Leu Glu Asp Pro Tyr Ser Gln Gln Ile Arg Leu Gln Gln Gln 

    930                 935                 940                 





Gln Ala Gln Gln Pro Leu Gln Gln Gln Gln Gln Arg Asn Ala Tyr Thr 

945                 950                 955                 960 





Arg Phe 

        





<210>  134

<211>  3115

<212>  DNA

<213>  Homo sapiens



<400>  134

ccacccgcct ctggctcctc tccttcccac ccctgccgtg ctccggcagg aagaggtggt       60



gccagggccg ttgctaggat acgaccaaca gctgagaacg cggcgagtat ggaagctgcg      120



tcttaggagc ctgggaaagc acttcgacga gaatagtttg gtttcgtaca caggaaaatg      180



tctaatcaac aggagaagta tgaagctcag aatatagtca attcaacaga agagagtgat      240



gatgcttttg atactgtcac tattccagtt ccctcagaag agcctcaaga gtcagatcaa      300



actgaagagc atgaatctgg aatagaacaa ttcagtgaga gccatgcaat acatgttgag      360



gagcagagtg accaaagctt ttcaagcctg gaaccagaca atgaacaact catggaagag      420



gttatatcac caagacaagt ttcatatact ccgcaacatc atgaaaagca atatgcaatg      480



cagaggccaa atgatgatag tttggcattt ctggataaaa taaagtctgt aaaggaatct      540



ttgcaagaat cagtggaaga ttctctagca acagtaaaag ttgtacttat tccagtgggc      600



caggaaattg taataccttt taaggttgat accattctta aatatcttaa ggaccatttt      660



tcacacttat taggtatccc acattctgta ctgcagataa gatactcagg aaaaattctt      720



aaaaataatg agactctagt acaacatgga gttaagccac aggaaattgt acaagtggaa      780



atcttttcta caaatccaga tctgtatcca gtcagaagaa tagatggatt aactgatgtc      840



tctcaaatca taactgtcac tgtccaaact ggacttgatc aataccagca ggtacctgtt      900



gagattgtca aatctgactt tcacaaacca tttcttggtg gattcagaca taaagtaaca      960



ggagtagagt atcacaatgc tggaacacaa actgtaccta aaaggattcc cgaaagactc     1020



agtatatttt gtagggatac gcagacagtt tttcagaaaa aaaatctcca acaaactaca     1080



aatacaacat ccacacagat gactaacatt ggtgtatatg tatcaaatat gactgataaa     1140



ctggtaacac caggaaagta tttttcagca gcagaatacc atgctcaaag actaaaggcg     1200



gtgatagtga tacagactta ctacaggcaa tggcatgcta aaatcttcgt agagaattta     1260



agaagacaga aaagcttaag actggaatgg gaaacacagc aagaactaag gaagataaga     1320



gaaaaagaag aatggataaa attggactat caccggaggc ataatcctaa aacaaatgaa     1380



gattttgaat ttctttataa tgcattagaa ttctggcggc aagaagaact tacacgtatt     1440



aaccaatctt ttactggagc tgaaaggaaa gctgctctgt gtgaacttct ggaaaaagag     1500



actcagataa ttgcttccat tgggagacat agatacattg cttatatggc aaatcaggaa     1560



gcagcaatac aagctttttt ggataagtgt tcagctccaa aaatatggag aacccctaat     1620



ggcaaaacaa ttgagatgga tacgcagttc accatcagag ccagagagct gcaaaatatc     1680



tataagtgca ttatgctgaa aaatatctcc caagatgaga ggctggatgt gctgttaact     1740



cttaaacaca ctgtaaagga acatgaatgt aaactaactc aggaaattct agaattgatt     1800



gacagagagg ttgaccttat gatgagagga gtcaaacatc ataaccttga aggactcaga     1860



aaaagaattg cgacactctt ttttcattat atcaaaacac ctctgtttaa tcctgaagtt     1920



gcaaaatacc ttaaggtccc tcaagaccca ttgaaatttt ataagaagat ttacttttgc     1980



cacagttgcc agctttattt gccttctaca gaattttctg tatcatccac ctcacgccgc     2040



atataccggt gtcgtaactg cattaacctt cagaatgagg ctcaaaaacg agaatcattt     2100



ttgaagtaca aatgtttact tcaacagctc tactatacag aagctgatta tgaagatgat     2160



tctaaaattg ctttcttgat gcagctacaa gacattcagt acctgacaga gaacatctgg     2220



gcgtcccagt cagtcctcag tgcttgcgac aatctcagtg atctggtcat ggtcagatgg     2280



aataaatccc tggagtggtc cccctggaac tgcattcttc ttaccaaaga tgaagcagct     2340



gctcatctca agctaacaag tattgaagag ggatatgaac gctcatttat tcacaagatc     2400



aaacacaaac atatcctggc taagaactat ttttctcagg ttccagtgct ggcttcattt     2460



atacttgatg atggtgaaat tgatgagatc agatggaagt atcactcaga cacaacacct     2520



aagattatag aatcccagag gcctcctcat taggtgatcc aggagtattt gtttgatgat     2580



cggcattttg ttcactgcta atagggtaat acagaggtca cagagtatgg aaatggaatt     2640



taatctgttt attgattttg ttttttgttt ttcatagtat tttgagttat ataaagagaa     2700



aacatttcta tataagtaag tattctttgt taggaagttg gtgctaaatt gaaatgcaat     2760



tttgttactg aaattaatat tttggggtaa agaaaacatt ttaaaatgtg ttttcacatt     2820



aaatttttta aattttttca agtatattag agttaaaatc taacaaacag ccaaataaaa     2880



actagacaac tttcaagtta tttattttag atagaatgta gttataggaa gctaatcagt     2940



atgtggaggg gaggaaacat tataaagtgc tctttcttga aaacttcttt aagtaggata     3000



aaaaaattta tattttagta taggcatttg aatctttgca gtttatcgtc tgctttcacc     3060



ttccatcctt ctcataatcc caataaaaca acacttgaaa ctatttataa ataaa          3115





<210>  135

<211>  791

<212>  PRT

<213>  Homo sapiens



<400>  135



Met Ser Asn Gln Gln Glu Lys Tyr Glu Ala Gln Asn Ile Val Asn Ser 

1               5                   10                  15      





Thr Glu Glu Ser Asp Asp Ala Phe Asp Thr Val Thr Ile Pro Val Pro 

            20                  25                  30          





Ser Glu Glu Pro Gln Glu Ser Asp Gln Thr Glu Glu His Glu Ser Gly 

        35                  40                  45              





Ile Glu Gln Phe Ser Glu Ser His Ala Ile His Val Glu Glu Gln Ser 

    50                  55                  60                  





Asp Gln Ser Phe Ser Ser Leu Glu Pro Asp Asn Glu Gln Leu Met Glu 

65                  70                  75                  80  





Glu Val Ile Ser Pro Arg Gln Val Ser Tyr Thr Pro Gln His His Glu 

                85                  90                  95      





Lys Gln Tyr Ala Met Gln Arg Pro Asn Asp Asp Ser Leu Ala Phe Leu 

            100                 105                 110         





Asp Lys Ile Lys Ser Val Lys Glu Ser Leu Gln Glu Ser Val Glu Asp 

        115                 120                 125             





Ser Leu Ala Thr Val Lys Val Val Leu Ile Pro Val Gly Gln Glu Ile 

    130                 135                 140                 





Val Ile Pro Phe Lys Val Asp Thr Ile Leu Lys Tyr Leu Lys Asp His 

145                 150                 155                 160 





Phe Ser His Leu Leu Gly Ile Pro His Ser Val Leu Gln Ile Arg Tyr 

                165                 170                 175     





Ser Gly Lys Ile Leu Lys Asn Asn Glu Thr Leu Val Gln His Gly Val 

            180                 185                 190         





Lys Pro Gln Glu Ile Val Gln Val Glu Ile Phe Ser Thr Asn Pro Asp 

        195                 200                 205             





Leu Tyr Pro Val Arg Arg Ile Asp Gly Leu Thr Asp Val Ser Gln Ile 

    210                 215                 220                 





Ile Thr Val Thr Val Gln Thr Gly Leu Asp Gln Tyr Gln Gln Val Pro 

225                 230                 235                 240 





Val Glu Ile Val Lys Ser Asp Phe His Lys Pro Phe Leu Gly Gly Phe 

                245                 250                 255     





Arg His Lys Val Thr Gly Val Glu Tyr His Asn Ala Gly Thr Gln Thr 

            260                 265                 270         





Val Pro Lys Arg Ile Pro Glu Arg Leu Ser Ile Phe Cys Arg Asp Thr 

        275                 280                 285             





Gln Thr Val Phe Gln Lys Lys Asn Leu Gln Gln Thr Thr Asn Thr Thr 

    290                 295                 300                 





Ser Thr Gln Met Thr Asn Ile Gly Val Tyr Val Ser Asn Met Thr Asp 

305                 310                 315                 320 





Lys Leu Val Thr Pro Gly Lys Tyr Phe Ser Ala Ala Glu Tyr His Ala 

                325                 330                 335     





Gln Arg Leu Lys Ala Val Ile Val Ile Gln Thr Tyr Tyr Arg Gln Trp 

            340                 345                 350         





His Ala Lys Ile Phe Val Glu Asn Leu Arg Arg Gln Lys Ser Leu Arg 

        355                 360                 365             





Leu Glu Trp Glu Thr Gln Gln Glu Leu Arg Lys Ile Arg Glu Lys Glu 

    370                 375                 380                 





Glu Trp Ile Lys Leu Asp Tyr His Arg Arg His Asn Pro Lys Thr Asn 

385                 390                 395                 400 





Glu Asp Phe Glu Phe Leu Tyr Asn Ala Leu Glu Phe Trp Arg Gln Glu 

                405                 410                 415     





Glu Leu Thr Arg Ile Asn Gln Ser Phe Thr Gly Ala Glu Arg Lys Ala 

            420                 425                 430         





Ala Leu Cys Glu Leu Leu Glu Lys Glu Thr Gln Ile Ile Ala Ser Ile 

        435                 440                 445             





Gly Arg His Arg Tyr Ile Ala Tyr Met Ala Asn Gln Glu Ala Ala Ile 

    450                 455                 460                 





Gln Ala Phe Leu Asp Lys Cys Ser Ala Pro Lys Ile Trp Arg Thr Pro 

465                 470                 475                 480 





Asn Gly Lys Thr Ile Glu Met Asp Thr Gln Phe Thr Ile Arg Ala Arg 

                485                 490                 495     





Glu Leu Gln Asn Ile Tyr Lys Cys Ile Met Leu Lys Asn Ile Ser Gln 

            500                 505                 510         





Asp Glu Arg Leu Asp Val Leu Leu Thr Leu Lys His Thr Val Lys Glu 

        515                 520                 525             





His Glu Cys Lys Leu Thr Gln Glu Ile Leu Glu Leu Ile Asp Arg Glu 

    530                 535                 540                 





Val Asp Leu Met Met Arg Gly Val Lys His His Asn Leu Glu Gly Leu 

545                 550                 555                 560 





Arg Lys Arg Ile Ala Thr Leu Phe Phe His Tyr Ile Lys Thr Pro Leu 

                565                 570                 575     





Phe Asn Pro Glu Val Ala Lys Tyr Leu Lys Val Pro Gln Asp Pro Leu 

            580                 585                 590         





Lys Phe Tyr Lys Lys Ile Tyr Phe Cys His Ser Cys Gln Leu Tyr Leu 

        595                 600                 605             





Pro Ser Thr Glu Phe Ser Val Ser Ser Thr Ser Arg Arg Ile Tyr Arg 

    610                 615                 620                 





Cys Arg Asn Cys Ile Asn Leu Gln Asn Glu Ala Gln Lys Arg Glu Ser 

625                 630                 635                 640 





Phe Leu Lys Tyr Lys Cys Leu Leu Gln Gln Leu Tyr Tyr Thr Glu Ala 

                645                 650                 655     





Asp Tyr Glu Asp Asp Ser Lys Ile Ala Phe Leu Met Gln Leu Gln Asp 

            660                 665                 670         





Ile Gln Tyr Leu Thr Glu Asn Ile Trp Ala Ser Gln Ser Val Leu Ser 

        675                 680                 685             





Ala Cys Asp Asn Leu Ser Asp Leu Val Met Val Arg Trp Asn Lys Ser 

    690                 695                 700                 





Leu Glu Trp Ser Pro Trp Asn Cys Ile Leu Leu Thr Lys Asp Glu Ala 

705                 710                 715                 720 





Ala Ala His Leu Lys Leu Thr Ser Ile Glu Glu Gly Tyr Glu Arg Ser 

                725                 730                 735     





Phe Ile His Lys Ile Lys His Lys His Ile Leu Ala Lys Asn Tyr Phe 

            740                 745                 750         





Ser Gln Val Pro Val Leu Ala Ser Phe Ile Leu Asp Asp Gly Glu Ile 

        755                 760                 765             





Asp Glu Ile Arg Trp Lys Tyr His Ser Asp Thr Thr Pro Lys Ile Ile 

    770                 775                 780                 





Glu Ser Gln Arg Pro Pro His 

785                 790     





<210>  136

<211>  1782

<212>  DNA

<213>  Homo sapiens



<400>  136

gaattccgga aatgaccctg cccgggggcc caacgggcat ggcgcggccg gggggcgcga       60



ggccctgcag cccggggctg gagcgggccc cgcgccggag tgtcggggag ctgcgcctgc      120



tcttcgaggc gcgctgtgcg gcggtcgctg cggccgccgc cgcgggggag ccccgggccc      180



gcggggccaa gcggcgtggg ggacaggtcc ccaacgggct tccgcgggct cccccggccc      240



cggtgatccc tcagctgacc gtgacagccg aggagcccga cgtgcccccg accagccctg      300



ggccgccgga gcgggagagg gactgcctcc cggcagcggg ctcttcgcac ctgcagcagc      360



cgcgccgcct ttccacctcg tcggtctcct ccactggctc ctcgtcgctg ctcgaggact      420



cggaggacga cctgctgagc gacagtgaga gccggagccg cggcaacgtg cagctggaag      480



cgggcgagga cgtgggtcag aaaaaccact ggcagaagat ccggaccatg gtcaatctgc      540



cggtcataag ccctttcaag aagcgctacg cctgggtgca gctggcaggg cacactggga      600



gttttaaggc ggcgggcacc agcgggctga tcctgaagcg ctgctcggag ccggagcgct      660



actgcctggc gcggctgatg gctgacgcgc tgcgcggctg cgtgcctgcc ttccacggcg      720



tggtggagcg cgacggcgaa agctacctgc agctgcagga cctgctcgat ggcttcgacg      780



gaccttgtgt gctcgactgc aaaatgggcg tcaggactta cctagaggag gagctgacca      840



aggcccgtga gcggcccaag ctgcggaagg acatgtacaa gaaaatgctg gcggtggatc      900



ctgaagctcc cacggaggag gagcacgcgc agcgcgccgt caccaagccg cgctacatgc      960



agtggcggga aggcatcagc tccagcacca ccctcggctt ccgcatcgag ggcatcaaga     1020



aagcggacgg ctcctgcagc accgacttca agactacgcg aagccgagag caggtgcttc     1080



gcgtctttga agagtttgtg caaggagatg aggaagtgct gaggcggtat ctgaaccgcc     1140



tgcagcagat ccgggacacc ctggaggtat ccgagttctt caggaggcac gaggtgatcg     1200



gcagctcgct cctctttgtg cacgatcact gccatcgcgc cggcgtgtgg ctcatcgact     1260



tcggcaagac cacgcccctc cccgatggcc agatcctgga ccaccggcgg ccctgggagg     1320



agggcaaccg cgaggacggc tatttgctgg ggctggacaa tctcattggc atcctggcca     1380



gcctggctga gagatgaggc tggactcctg tccccgcggg ccgctcacct gacatgtgga     1440



cctgcagctt tgtccccact gtgcatgccg gcttgagact ggagccccgc ggtgcagggc     1500



agttcaccgg gtcctgcagg accaggtgcc agccactaag ggggggcacc gccgatgcca     1560



ggggttttgc ccacccgggc cccagcgttc ccagagccaa atgacactaa cttatagaag     1620



gggagggggc aaagggcttc ttcctcaggc cagctcttct gaggaggctc tgccctctcc     1680



agaggtgcca gaccgcggat tttatttagc aagcccagac cttccggtct aacgtctcac     1740



accacgacgg actccccttc ctaataaaac tcaaagacaa aa                        1782





<210>  137

<211>  461

<212>  PRT

<213>  Homo sapiens



<400>  137



Met Thr Leu Pro Gly Gly Pro Thr Gly Met Ala Arg Pro Gly Gly Ala 

1               5                   10                  15      





Arg Pro Cys Ser Pro Gly Leu Glu Arg Ala Pro Arg Arg Ser Val Gly 

            20                  25                  30          





Glu Leu Arg Leu Leu Phe Glu Ala Arg Cys Ala Ala Val Ala Ala Ala 

        35                  40                  45              





Ala Ala Ala Gly Glu Pro Arg Ala Arg Gly Ala Lys Arg Arg Gly Gly 

    50                  55                  60                  





Gln Val Pro Asn Gly Leu Pro Arg Ala Pro Pro Ala Pro Val Ile Pro 

65                  70                  75                  80  





Gln Leu Thr Val Thr Ala Glu Glu Pro Asp Val Pro Pro Thr Ser Pro 

                85                  90                  95      





Gly Pro Pro Glu Arg Glu Arg Asp Cys Leu Pro Ala Ala Gly Ser Ser 

            100                 105                 110         





His Leu Gln Gln Pro Arg Arg Leu Ser Thr Ser Ser Val Ser Ser Thr 

        115                 120                 125             





Gly Ser Ser Ser Leu Leu Glu Asp Ser Glu Asp Asp Leu Leu Ser Asp 

    130                 135                 140                 





Ser Glu Ser Arg Ser Arg Gly Asn Val Gln Leu Glu Ala Gly Glu Asp 

145                 150                 155                 160 





Val Gly Gln Lys Asn His Trp Gln Lys Ile Arg Thr Met Val Asn Leu 

                165                 170                 175     





Pro Val Ile Ser Pro Phe Lys Lys Arg Tyr Ala Trp Val Gln Leu Ala 

            180                 185                 190         





Gly His Thr Gly Ser Phe Lys Ala Ala Gly Thr Ser Gly Leu Ile Leu 

        195                 200                 205             





Lys Arg Cys Ser Glu Pro Glu Arg Tyr Cys Leu Ala Arg Leu Met Ala 

    210                 215                 220                 





Asp Ala Leu Arg Gly Cys Val Pro Ala Phe His Gly Val Val Glu Arg 

225                 230                 235                 240 





Asp Gly Glu Ser Tyr Leu Gln Leu Gln Asp Leu Leu Asp Gly Phe Asp 

                245                 250                 255     





Gly Pro Cys Val Leu Asp Cys Lys Met Gly Val Arg Thr Tyr Leu Glu 

            260                 265                 270         





Glu Glu Leu Thr Lys Ala Arg Glu Arg Pro Lys Leu Arg Lys Asp Met 

        275                 280                 285             





Tyr Lys Lys Met Leu Ala Val Asp Pro Glu Ala Pro Thr Glu Glu Glu 

    290                 295                 300                 





His Ala Gln Arg Ala Val Thr Lys Pro Arg Tyr Met Gln Trp Arg Glu 

305                 310                 315                 320 





Gly Ile Ser Ser Ser Thr Thr Leu Gly Phe Arg Ile Glu Gly Ile Lys 

                325                 330                 335     





Lys Ala Asp Gly Ser Cys Ser Thr Asp Phe Lys Thr Thr Arg Ser Arg 

            340                 345                 350         





Glu Gln Val Leu Arg Val Phe Glu Glu Phe Val Gln Gly Asp Glu Glu 

        355                 360                 365             





Val Leu Arg Arg Tyr Leu Asn Arg Leu Gln Gln Ile Arg Asp Thr Leu 

    370                 375                 380                 





Glu Val Ser Glu Phe Phe Arg Arg His Glu Val Ile Gly Ser Ser Leu 

385                 390                 395                 400 





Leu Phe Val His Asp His Cys His Arg Ala Gly Val Trp Leu Ile Asp 

                405                 410                 415     





Phe Gly Lys Thr Thr Pro Leu Pro Asp Gly Gln Ile Leu Asp His Arg 

            420                 425                 430         





Arg Pro Trp Glu Glu Gly Asn Arg Glu Asp Gly Tyr Leu Leu Gly Leu 

        435                 440                 445             





Asp Asn Leu Ile Gly Ile Leu Ala Ser Leu Ala Glu Arg 

    450                 455                 460     





<210>  138

<211>  9178

<212>  DNA

<213>  Homo sapiens



<400>  138

aaagatggcc ggagcggcgg cggcggtggc cgcgggagca gcagctggag ccgccgcggc       60



agccgtgtcg gtggcggctc ccggccgggc ctcggcgcct ccgccgcccc cgcccgtgta      120



ctgtgtgtgc cggcagccgt acgacgtgaa ccgcttcatg atcgagtgcg atatctgcaa      180



ggactggttc cacggcagct gtgttggagt agaagaacat catgctgttg acattgacct      240



gtatcactgt cccaactgtg cagttttaca tggttcctcc ttgatgaaaa aaaggaggaa      300



ctggcacaga catgactaca cagaaattga tgatggttcc aaaccagtgc aagctggaac      360



tagaactttc attaaggaat tacgctctcg agtcttccca agtgccgatg aaataattat      420



aaagatgcat ggcagccagc tgacacaaag atatctggag aaacatggat ttgatgtccc      480



tattatggtc ccaaaattag atgatctagg actcaggctc ccttcaccta cattttctgt      540



gatggatgtg gaacgttatg taggtggtga caaagtgata gatgtcattg atgtggcgag      600



gcaggcagac agcaaaatga cacttcacaa ttatgttaaa tacttcatga atcctaacag      660



accaaaagtg ttaaatgtga tcagccttga attttcagat acaaagatgt ctgaattggt      720



ggaggtccct gatatagcca aaaaactttc ctgggtggaa aattattggc cagatgattc      780



agtctttccc aagccatttg ttcagaaata ttgcttaatg ggagttcaag acagctatac      840



agatttccac attgacttcg gtggaacttc agtctggtac catgtcctct ggggtgagaa      900



gattttttat ttaataaagc caacagatga aaatttggca cgttatgaat cttggagttc      960



atctgtgacc cagagtgagg tgttctttgg agataaggtg gataaatgct acaaatgtgt     1020



ggtaaagcag ggacatacct tatttgttcc tacagggtgg atccatgctg tgctcacttc     1080



tcaggactgt atggcttttg gggggaactt cctgcacaac cttaacattg gcatgcagct     1140



caggtgttat gagatggaga aaaggctaaa aacaccagat cttttcaaat tccctttctt     1200



tgaagccata tgttggtttg tagccaaaaa cttgctggaa accctgaaag aactgagaga     1260



agatggtttc cagcctcaaa cttacctagt acagggagtg aaagcactgc atactgcttt     1320



aaaattatgg atgaaaaaag aacttgtatc tgaacatgcc tttgaaattc cagacaatgt     1380



tagacctgga caccttatta aagaactttc taaagtaatt cgagcaatag aggaggaaaa     1440



cggcaaacca gttaaatctc agggaattcc tattgtgtgt ccagtttcac gatcctcaaa     1500



tgaagcaact tccccatacc attcccgaag aaagatgagg aaacttcgag atcataatgt     1560



ccgaactcct tctaacctag acatcctaga gctccacaca agggaggtcc tcaaaagatt     1620



agagatgtgt ccatgggaag aggacatctt gagctctaaa ctgaatggaa aattcaacaa     1680



acatctccaa ccatcctcca cagtacctga atggagagcg aaagataatg atctacgatt     1740



actgctgaca aatggaagaa taattaaaga tgaaaggcag ccctttgcag atcaaagtct     1800



ttatacagca gatagtgaaa atgaagagga taaaagaagg acaaaaaagg caaaaatgaa     1860



gatagaagag agttcaggag tagagggagt ggaacatgaa gaatctcaaa aaccactgaa     1920



tgggtttttt acacgtgtga aatcagaact caggagtaga tcatcaggat attctgatat     1980



ttctgagtca gaagactccg gacccgagtg cactgcactg aaaagtatct ttaccactga     2040



agagtctgaa agttcaggtg atgaaaagaa acaagaaata acatccaact ttaaggagga     2100



atctaatgtg atgaggaact tccttcaaaa gagccagaag ccatctagaa gtgaaattcc     2160



aattaaaagg gaatgtccta cctcgacgag cacagaggaa gaagctattc agggcatgct     2220



gtctatggca gggttgcact attccacgtg tttacaaagg caaatacaaa gcacagactg     2280



cagtggtgaa agaaactctc tccaggatcc cagcagctgc catggcagta accatgaggt     2340



taggcagttg tatcgctatg ataaaccagt ggaatgtgga taccatgtca agactgaaga     2400



tccagacttg aggacttcct cctggattaa acagtttgat acttccagat ttcatcctca     2460



ggatctaagt agaagccaga aatgcatcag aaaggaaggt tcatcagaaa ttagtcagag     2520



ggtacaaagt aggaattatg tggacagcag cggctcaagc cttcagaatg gaaagtatat     2580



gcagaattca aacctgactt cgggggcgtg ccagataagt aatggcagtc taagcccaga     2640



aaggccagtt ggtgaaactt ccttctcggt gccccttcac cccaccaaga gaccggcatc     2700



aaatccacca cctatcagca accaggcaac aaaaggtaaa cgtccaaaaa aaggaatggc     2760



aacagccaaa caacgtcttg ggaagatcct taagttgaac agaaatggcc atgcacgttt     2820



ctttgtgtga cagagctgct gttgcagcca ttcttccctt tggagaccag tctaggggtg     2880



caggagcctg gagcttccgc tgtccccctg cctggagcag tttgtgtgta tagtaagaac     2940



actgcccgaa gaacagaatg aacctgatgc tgcattttca ctgtgccaca cccactcagc     3000



aataaccatt ttggacctgg tgggggagag gaagaaggag ggtagaacct taaaaagaga     3060



ccttgaactg gaaagggtct cttgtcaggg cttgaatttt attttgttgt tggtagtgtc     3120



ttgatgtatt ttcagtggta gggtaaagaa ttatcaataa tttatttaac agattttttt     3180



ttaaagttaa cagcttttaa attctttttt taaagctatt tatttggaag atttctggag     3240



aaatatctca ctaatttaga tgtaagaatg tgaaggtttt taaattattt ttgatagtgt     3300



gtgtgttaca tgtggggaag ggccacagta acagtaacta gtctggactc ttaaatttga     3360



tattcaggtt aaagtcttaa acagggattt gatgcattaa ttattttaaa ttaagatgta     3420



tatgaaaatc attttatttt atatatttca tgtgtttttt ataagctatt agcttcgctt     3480



ttgctaacat ccaaggtgca tactgttatc caggttgatt accttatatc ccaccttccc     3540



tctgcactcc ccatcatttt gtgatgaccc agtaagactc ttctctttgc agggaaacac     3600



tttcgtagcc aatgtgtaag aactccatga aagatccctc atttctcatt tcgtttgaca     3660



ttgtgatttt cttctcaaca ttaaaaaaaa taggcttttg cattttcatt tctgctgatg     3720



atatctgggt cccaaagaga gcagctttaa tatatttttc ctacttgtgg gaaaagtatt     3780



ataagtttgg ttaaattgtc atgtttatag tttttccaag tacatttgta actacagcag     3840



gccttcttcg tactgctgct gttggacaac aggactggca cctgctgcag aggttatacc     3900



ttatgatact tttatgctcc atacctgatt tgttgggaaa tgttatttag gatattcaaa     3960



tctgcatcat aagccgtaat ataataggat taatactaca ttaagttgta tagaagcaag     4020



catgttggaa tagatctttt gtgtgtattt acttttttta tttcttaatt ttctaaagaa     4080



ttacttaaga tatggatttg gagtaaaatg ggtgcttttg gcagtttctt ccatctatcc     4140



taacctgacc agtacatatt gaggttaagt atctggttaa actttaaggt attcatttat     4200



ctcctttatg tatgattttt actaaatgcc agttttcatt tgcttatagt agcttctatt     4260



ttcccttttt tccatccatg gcataaaaat aagtgatttc tgggggtggg gcagaaatgt     4320



tcccaagtct gacaatagag cattttacaa attcctacaa agaaaatata ggcaaataga     4380



taaaatttat ttttatggag aagaaatatg gccatattat ggatttgtct tttttttact     4440



cagcaagata gcaggactta cccttctcta ttaagtatca cttgaattgc taagaagaaa     4500



aaagtctgta ccatcatctt tcatggttgc attcaaatgt atattttcaa agagaaatac     4560



ttcttgtgtc cccattccaa aatgtcatgg gataaatatg aaatagttta tgaagtagcc     4620



tttctggttc agagtgactg gaccaaagtc tgaatcttat ctgggtatca ggaaaaagaa     4680



tttttatgga aatccttagt gtctataaac aacccgtgta aaccctgtct acactatgcc     4740



aaaaccagtg gaaagatggg tagagtcatc ttatctcagg atgtcaaaaa tctgggtttg     4800



actgattccc ctaccttccc acacagtata ttcttgtgat ttttgctttt ctgtagatcc     4860



tgagtcggtg ttacaatagt catgttttta ttttgggtta agaaatacga ggtgtaagag     4920



ctataatttc cttttcgtgt tatatcatga tctgggtttt cttttttcct ttacgttttt     4980



cacagctctt gagtattttc tatttttttc tttagtcaca aaaattaaaa ttaaacttta     5040



tttttatgaa ttaaaatgaa atttaattta tttttatgaa ttaaaattgt ggccagtatc     5100



cactgtgtcc ttaggctgag aagtactaat ttggagtagc ccgtgtgtgg aattctaaag     5160



tgaaggtact gtggattcat ttttagtagt tttagcccct taataagtgg ctaagttaga     5220



aaactttcag cgaggtaata gaaccacttg aatagaatcc atgtgtcttt ttctgaattg     5280



gtgaaaattc ggccactgat ccagtgactc ctggtcaaac gtcttataac attactggcc     5340



ataatgcatc cctttatctc atggaaatgg ctgaactttg tggtagctgc tgcgagtacc     5400



tgggcttaac agtaatagag aacctcattt ataccataca gacacagcaa cttaggaaga     5460



cagcactgat agcatttagc tagttgtaac caaatacaaa tatgtaaaat tgagaattat     5520



gattaacata tgcaacttta gtaataggaa tagatgataa ttttcctgta ttgtttcaaa     5580



taagtgactg ttcagctggg atccattgga ttataattta caatgtcaca taatattatg     5640



cttttcaata ttgatgagtg atgtaaacaa tataaagttg gcagtttgta gtagttcagt     5700



atcctagaaa tacattgaac ttcataagta tcagttcatt tttaagcata cagaattgaa     5760



gattctgact gaaatcataa actcagagga aacaagccca tctttatcac taattactta     5820



gcttgaatac ttttctattt ttaaataatc ctaattattg ccttttcaat tatagtctac     5880



tgtatttatt tatatgggat caacaggtat ttatcaaaca tctactgtgt gcccagcact     5940



acctagtact gttggggaac atcaatttgc agttgtggtc tctgcccttg aaggtatctt     6000



ctccaggaaa ttagcagtat tattttcact tctaagcaaa catgagcaaa agaggacctg     6060



ttcattaaaa aacatgctga cttttttagt ttcaactgag atatgccact gtagaagtga     6120



aagtaatttc acaattaaag aaatgcttca acttggtaat taatatggtc atacagggac     6180



ttggtgtagc atgcaaggaa gcagaagacc tgggcttttg tcgaagttct gccatttagg     6240



tatcagctgt gtaaccttga ataagtcact taactctttc tcttagtttt ctcatttgta     6300



aatttggatt aaagtgttta ttatgataat caattaagaa aatctcttaa cacttcatac     6360



atacagagaa cttatcatta agttaaaact ggcaattaat gcacctttat atatattttt     6420



aaatgaaaac taatactatt catgatgttt attttatatc aaatatatgc ccagggcatg     6480



ctactttaaa aatccgagga atctccaaca aggtgctgga ttaaaatcag atttcgtgct     6540



tgaagtggaa gaaaaatgaa gttgtttatg gataagagag tgagaatgtg tatcctcaag     6600



tacgttaaga tgatttaact gaaagatggc tttaggtttt tcttgaagaa ttaggaaagt     6660



accatcccca cagattcagc atactcttca ggtactagat aaaggtgaag gaagtcatgg     6720



aattaaaatg acttagcaac tccccaggga acttgtgggg agaatgaggt ggttagaaag     6780



gtgagaatgc acaaagacag ctctgggttg ggtaccaaca gtttgcttgg tagaaagaaa     6840



ccagtgtagg aaaggagacg ccaccagaca tcttcaacag acaagattct ttctgccttt     6900



ttcaaaagat gctctctgca gcagtaagac tatagataga gttgattgga atatcatgtg     6960



acccagtatg ctactgctag gcataattat caaaaattca tttttctcat taaatattgt     7020



taattgctcg ccacataaag agaagctaga gctcaccagt cttggtggtg tcctagacct     7080



tcctctaaag cagtcttggg aagctggatc atcagatctt tagcctagac agagtgtcgc     7140



tggtaaataa aggagacaca ggtaacccag agtggacagt gatttgcgtg gggagacaca     7200



gtggatctgg ggcctctgat actttgcttc ctaaaacagc ccccagtttt cggcttgccc     7260



tatgagatga tgttcatgtg cttccttgaa accaggtgga aagaaagggg aagaattaat     7320



tttctcattc tgttgctgtt gaacgtaatg taatcttaat actgtagcct tcctagaagc     7380



ccttccctct ttttcatgct gtaaagtcaa atatttgata tccttaacat aaattttaaa     7440



aattaaggtc attaggaagc aaatgtctat ttccaaagca atgagcttgt tgtgactgtg     7500



attttattct tctatagtat ttttttcctc attttaactg agaggagaaa ataatactct     7560



tttgcaatat ccttaggttc tccccttccc cctggtgccc cttctagtgt cttaagactt     7620



tgtcttaaca agtataacat tacattttgt tgttaaaacc tttcgaaact gtattcagtg     7680



attcttccaa gtttatctgc tctgcactat ttcactaata aaccctggct accacgtagc     7740



ccttgatctc caagtagttt acctatgcaa gacctgtgac actctgaatt cacttctctt     7800



tctttcagaa agtagtcata aatggagctt aattataaag gtaaaacttg tctccaacca     7860



gtttcatttt ggccatttct ttttcaaaat gtcagctgtt ttcctccaag atttttcacc     7920



aaaacaatga tcataagtgc tggaatatat aatactttgc aggcataaaa taacccagac     7980



atactctcat atttctttgg tgtattttgg ttggtaaaac ttaccagcat taaatgtaaa     8040



atataatgag gagttaattc cttacctaga actatttctt ccttttaaga ttcataagta     8100



accttttatt tttacagagc tacgtataac ttccacatta cagtcaggga cctgaggtgt     8160



aacttactaa gtgaacccca aggttatttt atcttgcaaa agaaacctaa accaaactaa     8220



gggccttaca gtttatggtt agactgaatc aaaagctata acctcaattt ttccaaaaac     8280



agcttctgac tgcaaaagca agtcatacag ttgttaggta tgaaatagca ctgatcagga     8340



aatgcatctt cgcagatggt atttccttca gaaaagactt ttctactttt aatataaatt     8400



aagccataac agtttcatgc tgtggaaaga gggtgaaaag gttcatttta agagattata     8460



taatatgaac tttcacattt actgtgaaat gtctaacttt gccagtgctt cagcaagttt     8520



ttttgggggg tgatggggag gggtagtatt ggttttagag gtttcaaatc tgtgaacttt     8580



ggagagggga cagttgttgg ctctggtatt tactagtttt gtagtaacgt tttgctagcc     8640



tgactgactt ttcttactgg tttttatgcc cacggtccga ggggactgtt cttcttgttg     8700



ggggtgtctg cggaatagcg tctcgtcttg tttgtatagg cagtcaatgt gtgtgacatg     8760



tgtgtccttt cagtccggaa gcccactgtg tgacaatggc gtggggtgtg gctgggaggt     8820



ggggtgctga agcttgaaga gcatttcttt gctgattcat aacagtattt cccatctttt     8880



gcctgcaggc agggaaagtg tacagtattt attttgtttc tgttttactt taaatttgta     8940



agtctttaag tagcttacat tgattattat aggggaggac aagtgacttg tttaaagttg     9000



tatttagtat tctttccaat ttctgtattt taaaatattg aaattaaaat tgtattactt     9060



ctgttttgat ttttttagca cttagtgtat tttttgctca ttttgtttga aagtataaat     9120



gttgaaaatt gtataaaatg cgtccttgaa agaaaaagaa tctgaattct atatccaa       9178





<210>  139

<211>  941

<212>  PRT

<213>  Homo sapiens



<400>  139



Met Ala Gly Ala Ala Ala Ala Val Ala Ala Gly Ala Ala Ala Gly Ala 

1               5                   10                  15      





Ala Ala Ala Ala Val Ser Val Ala Ala Pro Gly Arg Ala Ser Ala Pro 

            20                  25                  30          





Pro Pro Pro Pro Pro Val Tyr Cys Val Cys Arg Gln Pro Tyr Asp Val 

        35                  40                  45              





Asn Arg Phe Met Ile Glu Cys Asp Ile Cys Lys Asp Trp Phe His Gly 

    50                  55                  60                  





Ser Cys Val Gly Val Glu Glu His His Ala Val Asp Ile Asp Leu Tyr 

65                  70                  75                  80  





His Cys Pro Asn Cys Ala Val Leu His Gly Ser Ser Leu Met Lys Lys 

                85                  90                  95      





Arg Arg Asn Trp His Arg His Asp Tyr Thr Glu Ile Asp Asp Gly Ser 

            100                 105                 110         





Lys Pro Val Gln Ala Gly Thr Arg Thr Phe Ile Lys Glu Leu Arg Ser 

        115                 120                 125             





Arg Val Phe Pro Ser Ala Asp Glu Ile Ile Ile Lys Met His Gly Ser 

    130                 135                 140                 





Gln Leu Thr Gln Arg Tyr Leu Glu Lys His Gly Phe Asp Val Pro Ile 

145                 150                 155                 160 





Met Val Pro Lys Leu Asp Asp Leu Gly Leu Arg Leu Pro Ser Pro Thr 

                165                 170                 175     





Phe Ser Val Met Asp Val Glu Arg Tyr Val Gly Gly Asp Lys Val Ile 

            180                 185                 190         





Asp Val Ile Asp Val Ala Arg Gln Ala Asp Ser Lys Met Thr Leu His 

        195                 200                 205             





Asn Tyr Val Lys Tyr Phe Met Asn Pro Asn Arg Pro Lys Val Leu Asn 

    210                 215                 220                 





Val Ile Ser Leu Glu Phe Ser Asp Thr Lys Met Ser Glu Leu Val Glu 

225                 230                 235                 240 





Val Pro Asp Ile Ala Lys Lys Leu Ser Trp Val Glu Asn Tyr Trp Pro 

                245                 250                 255     





Asp Asp Ser Val Phe Pro Lys Pro Phe Val Gln Lys Tyr Cys Leu Met 

            260                 265                 270         





Gly Val Gln Asp Ser Tyr Thr Asp Phe His Ile Asp Phe Gly Gly Thr 

        275                 280                 285             





Ser Val Trp Tyr His Val Leu Trp Gly Glu Lys Ile Phe Tyr Leu Ile 

    290                 295                 300                 





Lys Pro Thr Asp Glu Asn Leu Ala Arg Tyr Glu Ser Trp Ser Ser Ser 

305                 310                 315                 320 





Val Thr Gln Ser Glu Val Phe Phe Gly Asp Lys Val Asp Lys Cys Tyr 

                325                 330                 335     





Lys Cys Val Val Lys Gln Gly His Thr Leu Phe Val Pro Thr Gly Trp 

            340                 345                 350         





Ile His Ala Val Leu Thr Ser Gln Asp Cys Met Ala Phe Gly Gly Asn 

        355                 360                 365             





Phe Leu His Asn Leu Asn Ile Gly Met Gln Leu Arg Cys Tyr Glu Met 

    370                 375                 380                 





Glu Lys Arg Leu Lys Thr Pro Asp Leu Phe Lys Phe Pro Phe Phe Glu 

385                 390                 395                 400 





Ala Ile Cys Trp Phe Val Ala Lys Asn Leu Leu Glu Thr Leu Lys Glu 

                405                 410                 415     





Leu Arg Glu Asp Gly Phe Gln Pro Gln Thr Tyr Leu Val Gln Gly Val 

            420                 425                 430         





Lys Ala Leu His Thr Ala Leu Lys Leu Trp Met Lys Lys Glu Leu Val 

        435                 440                 445             





Ser Glu His Ala Phe Glu Ile Pro Asp Asn Val Arg Pro Gly His Leu 

    450                 455                 460                 





Ile Lys Glu Leu Ser Lys Val Ile Arg Ala Ile Glu Glu Glu Asn Gly 

465                 470                 475                 480 





Lys Pro Val Lys Ser Gln Gly Ile Pro Ile Val Cys Pro Val Ser Arg 

                485                 490                 495     





Ser Ser Asn Glu Ala Thr Ser Pro Tyr His Ser Arg Arg Lys Met Arg 

            500                 505                 510         





Lys Leu Arg Asp His Asn Val Arg Thr Pro Ser Asn Leu Asp Ile Leu 

        515                 520                 525             





Glu Leu His Thr Arg Glu Val Leu Lys Arg Leu Glu Met Cys Pro Trp 

    530                 535                 540                 





Glu Glu Asp Ile Leu Ser Ser Lys Leu Asn Gly Lys Phe Asn Lys His 

545                 550                 555                 560 





Leu Gln Pro Ser Ser Thr Val Pro Glu Trp Arg Ala Lys Asp Asn Asp 

                565                 570                 575     





Leu Arg Leu Leu Leu Thr Asn Gly Arg Ile Ile Lys Asp Glu Arg Gln 

            580                 585                 590         





Pro Phe Ala Asp Gln Ser Leu Tyr Thr Ala Asp Ser Glu Asn Glu Glu 

        595                 600                 605             





Asp Lys Arg Arg Thr Lys Lys Ala Lys Met Lys Ile Glu Glu Ser Ser 

    610                 615                 620                 





Gly Val Glu Gly Val Glu His Glu Glu Ser Gln Lys Pro Leu Asn Gly 

625                 630                 635                 640 





Phe Phe Thr Arg Val Lys Ser Glu Leu Arg Ser Arg Ser Ser Gly Tyr 

                645                 650                 655     





Ser Asp Ile Ser Glu Ser Glu Asp Ser Gly Pro Glu Cys Thr Ala Leu 

            660                 665                 670         





Lys Ser Ile Phe Thr Thr Glu Glu Ser Glu Ser Ser Gly Asp Glu Lys 

        675                 680                 685             





Lys Gln Glu Ile Thr Ser Asn Phe Lys Glu Glu Ser Asn Val Met Arg 

    690                 695                 700                 





Asn Phe Leu Gln Lys Ser Gln Lys Pro Ser Arg Ser Glu Ile Pro Ile 

705                 710                 715                 720 





Lys Arg Glu Cys Pro Thr Ser Thr Ser Thr Glu Glu Glu Ala Ile Gln 

                725                 730                 735     





Gly Met Leu Ser Met Ala Gly Leu His Tyr Ser Thr Cys Leu Gln Arg 

            740                 745                 750         





Gln Ile Gln Ser Thr Asp Cys Ser Gly Glu Arg Asn Ser Leu Gln Asp 

        755                 760                 765             





Pro Ser Ser Cys His Gly Ser Asn His Glu Val Arg Gln Leu Tyr Arg 

    770                 775                 780                 





Tyr Asp Lys Pro Val Glu Cys Gly Tyr His Val Lys Thr Glu Asp Pro 

785                 790                 795                 800 





Asp Leu Arg Thr Ser Ser Trp Ile Lys Gln Phe Asp Thr Ser Arg Phe 

                805                 810                 815     





His Pro Gln Asp Leu Ser Arg Ser Gln Lys Cys Ile Arg Lys Glu Gly 

            820                 825                 830         





Ser Ser Glu Ile Ser Gln Arg Val Gln Ser Arg Asn Tyr Val Asp Ser 

        835                 840                 845             





Ser Gly Ser Ser Leu Gln Asn Gly Lys Tyr Met Gln Asn Ser Asn Leu 

    850                 855                 860                 





Thr Ser Gly Ala Cys Gln Ile Ser Asn Gly Ser Leu Ser Pro Glu Arg 

865                 870                 875                 880 





Pro Val Gly Glu Thr Ser Phe Ser Val Pro Leu His Pro Thr Lys Arg 

                885                 890                 895     





Pro Ala Ser Asn Pro Pro Pro Ile Ser Asn Gln Ala Thr Lys Gly Lys 

            900                 905                 910         





Arg Pro Lys Lys Gly Met Ala Thr Ala Lys Gln Arg Leu Gly Lys Ile 

        915                 920                 925             





Leu Lys Leu Asn Arg Asn Gly His Ala Arg Phe Phe Val 

    930                 935                 940     





<210>  140

<211>  2988

<212>  DNA

<213>  Homo sapiens



<400>  140

aaggggcggg gccgaagcgg cccagggggc gggcgtttga aatcagtgcc ttagagtaga       60



ccctaaacct cattttatac cttcaagaac caattactta atgtctcttc cgtcttttcc      120



gtccccgacc ccctcccaga ctccttcatt ccggtactgc gtggacggaa agccccgggt      180



agccgacacc acgtccccgg ctagcgggag agagcgtgga aaaggattac accaaactgt      240



ttaaatccaa cgactcctgc ttccatcctt tctcctgagc tagaaccaac aaacctagag      300



agttgggctt cggaaaaact agtgttttca tttaattgga tatgaagaaa gaacaaatat      360



gtacggggca accacgatct ttacaaagaa cataagttcc aggaaagcag gaaccttgtc      420



tctcttgttc actgggtgta tcctctgcat atagaacagt gcctggcaca taataggtgc      480



tgaattttgt tctaaacact gaggacattc tctgctacat ttgggtcgta cccccaggtc      540



tgagtaattc aatagactta agaagacaga gcccagcagc aaccgaaaca taacagagtt      600



gcaggatcag ctaacgtcaa tgcctgggca aagctgctgc ccagagtgga atctcactag      660



tgaataaaca agcccaagaa agattatcat ctcatttgca aaaaaaaaag tacgctggta      720



gatcctgcta cctcatagat aacaccagtc aaattttttt ttaaagtagc attttcctac      780



attgtcaact atctagaaca tacctaaaaa ctaagagttt actgcttatt aaatggaaac      840



tatgaagtct aaggccaact gtgcccagaa tccaaattgt aacataatga tatttcatcc      900



aaccaaagaa gagtttaatg attttgataa atatattgct tacatggaat cccaaggtgc      960



acacagagct ggcttggcta agataattcc acccaaagaa tggaaagcca gagagaccta     1020



tgataatatc agtgaaatct taatagccac tcccctccag caggtggcct ctgggcgggc     1080



aggggtgttt actcaatacc ataaaaaaaa gaaagccatg actgtggggg agtatcgcca     1140



tttggcaaac agtaaaaaat atcagactcc accacaccag aatttcgaag atttggagcg     1200



aaaatactgg aagaaccgca tctataattc accgatttat ggtgctgaca tcagtggctc     1260



cttgtttgat gaaaacacta aacaatggaa tcttgggcac ctgggaacaa ttcaggacct     1320



gctggaaaag gaatgtgggg ttgtcataga aggcgtcaat acaccctact tgtactttgg     1380



catgtggaaa accacgtttg cttggcatac agaggacatg gacctttaca gcatcaacta     1440



cctgcacctt ggggagccca aaacttggta tgtggtgccc ccagaacatg gccagcgcct     1500



ggaacgcctg gccagggagc tcttcccagg cagttcccgg ggttgtgggg ccttcctgcg     1560



gcacaaggtg gccctcatct cgcctacagt tctcaaggaa aatgggattc ccttcaatcg     1620



cataactcag gaggctggag agttcatggt gacctttccc tatggctacc atgctggctt     1680



caaccatggt ttcaactgcg cagaggccat caattttgcc actccgcgat ggattgatta     1740



tggcaaaatg gcctcccagt gtagctgtgg ggaggcaagg gtgacctttt ccatggatgc     1800



cttcgtgcgc atcctgcaac ctgaacgcta tgacctgtgg aaacgtgggc aagaccgggc     1860



agttgtggac cacatggagc ccagggtacc agccagccaa gagctgagca cccagaagga     1920



agtccagtta cccaggagag cagcgctggg cctgagacaa ctcccttccc actgggcccg     1980



gcattcccct tggcctatgg ctgcccgcag tgggacacgg tgccacaccc ttgtgtgctc     2040



ttcactccca cgccgatctg cagttagtgg cactgctacg cagccccggg ctgctgctgt     2100



ccacagctct aagaagccca gctcaactcc atcatccacc cctggtccat ctgcacagat     2160



tatccacccg tcaaatggca gacgtggtcg tggtcgccct cctcagaaac tgagagctca     2220



ggagctgacc ctccagactc cagccaagag gcccctcttg gcgggcacaa catgcacagc     2280



ttcgggccca gaacctgagc ccctacctga ggatggggct ttgatggaca agcctgtacc     2340



actgagccca gggctccagc atcctgtcaa ggcttctggg tgcagctggg cccctgtgcc     2400



ctaagtccac gggctgtctt tatatcccac tgccctgctg tgtgacagtt tgatgaaact     2460



ggttacattt acatcccaaa actttggttg agtttgcagg actctaggca tgcatgaaag     2520



agcccccctg gtgatgccct tggatgctgc caagtccatg gtagttttca attttgccat     2580



acttttgttc ttcctaccgg accctggaat gtctttggat attgctaaaa tctatttctg     2640



cagctgaggt tttatccact ggacacattt gtgtgtgaga actaggtctt gttgaggtta     2700



gcgtaacctg gtatatgcaa ctaccatcct ctgggccaac tgtggaagct gctgcacttg     2760



tgaagaatcc tgagctttga ttcctcttca gtctacgcat ttctctcttc ccctccctca     2820



cccccttttt cttataaaac taggttcttt atacagataa ggtcagtaga gttccagaat     2880



aaaagatatg acttttctga gttatttatg tacttaaaat atgttgtcac agtatttgtt     2940



cccaaatata ttaaaggtaa ccaaaatgtt aaaaaaaaaa aaaaaaaa                  2988





<210>  141

<211>  523

<212>  PRT

<213>  Homo sapiens



<400>  141



Met Glu Thr Met Lys Ser Lys Ala Asn Cys Ala Gln Asn Pro Asn Cys 

1               5                   10                  15      





Asn Ile Met Ile Phe His Pro Thr Lys Glu Glu Phe Asn Asp Phe Asp 

            20                  25                  30          





Lys Tyr Ile Ala Tyr Met Glu Ser Gln Gly Ala His Arg Ala Gly Leu 

        35                  40                  45              





Ala Lys Ile Ile Pro Pro Lys Glu Trp Lys Ala Arg Glu Thr Tyr Asp 

    50                  55                  60                  





Asn Ile Ser Glu Ile Leu Ile Ala Thr Pro Leu Gln Gln Val Ala Ser 

65                  70                  75                  80  





Gly Arg Ala Gly Val Phe Thr Gln Tyr His Lys Lys Lys Lys Ala Met 

                85                  90                  95      





Thr Val Gly Glu Tyr Arg His Leu Ala Asn Ser Lys Lys Tyr Gln Thr 

            100                 105                 110         





Pro Pro His Gln Asn Phe Glu Asp Leu Glu Arg Lys Tyr Trp Lys Asn 

        115                 120                 125             





Arg Ile Tyr Asn Ser Pro Ile Tyr Gly Ala Asp Ile Ser Gly Ser Leu 

    130                 135                 140                 





Phe Asp Glu Asn Thr Lys Gln Trp Asn Leu Gly His Leu Gly Thr Ile 

145                 150                 155                 160 





Gln Asp Leu Leu Glu Lys Glu Cys Gly Val Val Ile Glu Gly Val Asn 

                165                 170                 175     





Thr Pro Tyr Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His 

            180                 185                 190         





Thr Glu Asp Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Leu Gly Glu 

        195                 200                 205             





Pro Lys Thr Trp Tyr Val Val Pro Pro Glu His Gly Gln Arg Leu Glu 

    210                 215                 220                 





Arg Leu Ala Arg Glu Leu Phe Pro Gly Ser Ser Arg Gly Cys Gly Ala 

225                 230                 235                 240 





Phe Leu Arg His Lys Val Ala Leu Ile Ser Pro Thr Val Leu Lys Glu 

                245                 250                 255     





Asn Gly Ile Pro Phe Asn Arg Ile Thr Gln Glu Ala Gly Glu Phe Met 

            260                 265                 270         





Val Thr Phe Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn 

        275                 280                 285             





Cys Ala Glu Ala Ile Asn Phe Ala Thr Pro Arg Trp Ile Asp Tyr Gly 

    290                 295                 300                 





Lys Met Ala Ser Gln Cys Ser Cys Gly Glu Ala Arg Val Thr Phe Ser 

305                 310                 315                 320 





Met Asp Ala Phe Val Arg Ile Leu Gln Pro Glu Arg Tyr Asp Leu Trp 

                325                 330                 335     





Lys Arg Gly Gln Asp Arg Ala Val Val Asp His Met Glu Pro Arg Val 

            340                 345                 350         





Pro Ala Ser Gln Glu Leu Ser Thr Gln Lys Glu Val Gln Leu Pro Arg 

        355                 360                 365             





Arg Ala Ala Leu Gly Leu Arg Gln Leu Pro Ser His Trp Ala Arg His 

    370                 375                 380                 





Ser Pro Trp Pro Met Ala Ala Arg Ser Gly Thr Arg Cys His Thr Leu 

385                 390                 395                 400 





Val Cys Ser Ser Leu Pro Arg Arg Ser Ala Val Ser Gly Thr Ala Thr 

                405                 410                 415     





Gln Pro Arg Ala Ala Ala Val His Ser Ser Lys Lys Pro Ser Ser Thr 

            420                 425                 430         





Pro Ser Ser Thr Pro Gly Pro Ser Ala Gln Ile Ile His Pro Ser Asn 

        435                 440                 445             





Gly Arg Arg Gly Arg Gly Arg Pro Pro Gln Lys Leu Arg Ala Gln Glu 

    450                 455                 460                 





Leu Thr Leu Gln Thr Pro Ala Lys Arg Pro Leu Leu Ala Gly Thr Thr 

465                 470                 475                 480 





Cys Thr Ala Ser Gly Pro Glu Pro Glu Pro Leu Pro Glu Asp Gly Ala 

                485                 490                 495     





Leu Met Asp Lys Pro Val Pro Leu Ser Pro Gly Leu Gln His Pro Val 

            500                 505                 510         





Lys Ala Ser Gly Cys Ser Trp Ala Pro Val Pro 

        515                 520             





<210>  142

<211>  3008

<212>  DNA

<213>  Homo sapiens



<400>  142

agttctcccg ggcgcctagc gggatcgcca gcgcggcagt gggggcttcc gcggctgcaa       60



gccagcgggt cctgtgaggg cgagcggagg cggagaaagg gcgcgggagt gagagagggt      120



gagtcagcca ctgtctatgc aataaaggga ggcctcaccg cgggataggg ctgaattcag      180



aagtgcggcc cgtgccgcag tctgttccag gacgcggctt gtcttagcgt cagcgaggga      240



aggttgagga ggagccagag cctggtcctg cagcctttct cgccgtcagc gcccgtcgcc      300



atctccacca tgcagtcccg ggaagacgtc ccgcgctctc gccgcctcgc cagtccccgt      360



ggtgggaggc ggcccaagag gatttccaag ccctcggttt cggccttttt cacgggtcca      420



gaggagttaa aggacacggc ccattctgca gccctgctgg cacagctcaa gtccttctac      480



gacgcgcggc tgctgtgtga tgtgaccatc gaggtggtga cgcctggcag cgggcctggc      540



acgggtcgcc tcttttcctg caatcgcaac gtgctagcag ctgcgtgtcc ctacttcaag      600



agcatgttca caggtggcat gtacgagagc cagcaggcca gcgtgaccat gcacgatgtg      660



gacgccgagt ccttcgaggt gttggtcgac tactgctaca cgggtcgtgt gtctctcagt      720



gaggccaatg tgcagcgcct gtacgcggcc tccgacatgc tacagctgga atatgtgcgg      780



gaagcctgtg cctccttctt agcccgacgt cttgacctga ccaactgcac cgccatcctc      840



aagtttgcag acgccttcga ccatcacaag cttcgatctc aggcccagtc ctacatagct      900



cacaacttca agcagctcag ccgaatgggt tcaattcggg aggagactct agcagatcta      960



accctggccc agctgctggc tgtcctacgc ctggatagtc tggacataga gagtgagcgg     1020



actgtatgcc atgtagctgt gcagtggctg gaggctgctg ccaaagagcg gggtcccagt     1080



gctgcagaag tcttcaagtg cgtgcgctgg atgcacttca ctgaagaaga tcaggactac     1140



ttagaagggc tgctgaccaa gcccatcgtg aagaagtact gcctggacgt tattgaaggg     1200



gccctgcaga tgcgctatgg tgacctgttg tacaagtctc tggtgccagt gccaaacagc     1260



agcagcagca gtagcagcag caactctctt gtatctgcag cagaaaatcc accccagaga     1320



ctgggtatgt gtgccaagga gatggtgatc ttctttggac atcctagaga tccctttctc     1380



tgctatgacc cttactcggg ggacatttac acaatgccat cccctttgac cagctttgct     1440



cacactaaga ctgtcacctc ctcagctgtc tgtgtgtccc cagaccatga catctatcta     1500



gctgctcagc ccaggaaaga cctctgggtg tataaaccag ctcagaatag ttggcagcaa     1560



cttgcagatc gcttgctgtg tcgtgagggc atggatgtgg catatctcaa tggctacatc     1620



tacattttgg ggggacgaga ccctattact ggagttaagt tgaaggaagt ggaatgctac     1680



agtgttcaga gaaaccagtg ggcattggtg gctcctgtcc ctcattcctt ctattccttt     1740



gaactcatag tggttcagaa ctatctttat gctgtcaaca gtaagcgcat gctttgctat     1800



gatcctagcc acaatatgtg gctgaactgt gcttctctta aacgtagtga ctttcaggaa     1860



gcatgtgtct tcaatgatga aatctattgt atctgtgaca tcccagtcat gaaggtctac     1920



aacccagcta ggggagaatg gaggcggatt agtaatattc ctttggattc agagacccac     1980



aactaccaga ttgtcaatca tgaccaaaag ttgcttctca tcacttctac aaccccacaa     2040



tggaaaaaga accgagtgac agtgtatgag tatgatacta gggaagatca gtggattaat     2100



ataggtacca tgttaggcct tttgcagttt gactctggct ttatttgcct ttgtgctcgt     2160



gtttatcctt cctgccttga acctggtcag agttttatta ctgaggaaga tgatgcacgg     2220



agtgagtcta gtactgaatg ggacttagat ggattcagtg agctggactc tgagtcagga     2280



agttcaagtt ctttttcaga tgatgaagtc tgggtgcaag tagcacctca gcgaaatgca     2340



caggatcagc agggttcttt gtaaatagta ttttgagaca ctaagatgtt tctactgcta     2400



cggaatgtat tttaaacaca tatcgtttct ttttcttgga aaaaaagttg attaggacca     2460



cagatttggt ttagaaaggg taatattttg aaatactaca aggtttagac agtccatgaa     2520



atcgacctgt ttaataattt accatcctga aagtccagaa ttaaaatatg gaagcaagaa     2580



ctatataatt gattaggatg cttggtaggt ttttttcatt gttcaaatat tcattgcaca     2640



gtggattgtt ttgattagtt agtatgcttt ttttttaatt aattcagtct tctgttaatt     2700



tttaagtttt ggttagtgcc acaaggaatt taactttttg atttgtataa tagaaaactg     2760



aactaggaat tgttagcggg gttttgaagg atgtgtactt tccttcaaaa taaagtggta     2820



gattttcaaa attttacact agtcagttct ttatattcta agttaaatgt agtttgtaaa     2880



attattttgg ttttcttcta caaaggaaaa aattggattt atatatataa ggttactgca     2940



taatgatttc attttgataa tgtgcagaat ggcctcataa gctcacagaa agcaaaaaaa     3000



aaaaaaaa                                                              3008





<210>  143

<211>  684

<212>  PRT

<213>  Homo sapiens



<400>  143



Met Gln Ser Arg Glu Asp Val Pro Arg Ser Arg Arg Leu Ala Ser Pro 

1               5                   10                  15      





Arg Gly Gly Arg Arg Pro Lys Arg Ile Ser Lys Pro Ser Val Ser Ala 

            20                  25                  30          





Phe Phe Thr Gly Pro Glu Glu Leu Lys Asp Thr Ala His Ser Ala Ala 

        35                  40                  45              





Leu Leu Ala Gln Leu Lys Ser Phe Tyr Asp Ala Arg Leu Leu Cys Asp 

    50                  55                  60                  





Val Thr Ile Glu Val Val Thr Pro Gly Ser Gly Pro Gly Thr Gly Arg 

65                  70                  75                  80  





Leu Phe Ser Cys Asn Arg Asn Val Leu Ala Ala Ala Cys Pro Tyr Phe 

                85                  90                  95      





Lys Ser Met Phe Thr Gly Gly Met Tyr Glu Ser Gln Gln Ala Ser Val 

            100                 105                 110         





Thr Met His Asp Val Asp Ala Glu Ser Phe Glu Val Leu Val Asp Tyr 

        115                 120                 125             





Cys Tyr Thr Gly Arg Val Ser Leu Ser Glu Ala Asn Val Gln Arg Leu 

    130                 135                 140                 





Tyr Ala Ala Ser Asp Met Leu Gln Leu Glu Tyr Val Arg Glu Ala Cys 

145                 150                 155                 160 





Ala Ser Phe Leu Ala Arg Arg Leu Asp Leu Thr Asn Cys Thr Ala Ile 

                165                 170                 175     





Leu Lys Phe Ala Asp Ala Phe Asp His His Lys Leu Arg Ser Gln Ala 

            180                 185                 190         





Gln Ser Tyr Ile Ala His Asn Phe Lys Gln Leu Ser Arg Met Gly Ser 

        195                 200                 205             





Ile Arg Glu Glu Thr Leu Ala Asp Leu Thr Leu Ala Gln Leu Leu Ala 

    210                 215                 220                 





Val Leu Arg Leu Asp Ser Leu Asp Ile Glu Ser Glu Arg Thr Val Cys 

225                 230                 235                 240 





His Val Ala Val Gln Trp Leu Glu Ala Ala Ala Lys Glu Arg Gly Pro 

                245                 250                 255     





Ser Ala Ala Glu Val Phe Lys Cys Val Arg Trp Met His Phe Thr Glu 

            260                 265                 270         





Glu Asp Gln Asp Tyr Leu Glu Gly Leu Leu Thr Lys Pro Ile Val Lys 

        275                 280                 285             





Lys Tyr Cys Leu Asp Val Ile Glu Gly Ala Leu Gln Met Arg Tyr Gly 

    290                 295                 300                 





Asp Leu Leu Tyr Lys Ser Leu Val Pro Val Pro Asn Ser Ser Ser Ser 

305                 310                 315                 320 





Ser Ser Ser Ser Asn Ser Leu Val Ser Ala Ala Glu Asn Pro Pro Gln 

                325                 330                 335     





Arg Leu Gly Met Cys Ala Lys Glu Met Val Ile Phe Phe Gly His Pro 

            340                 345                 350         





Arg Asp Pro Phe Leu Cys Tyr Asp Pro Tyr Ser Gly Asp Ile Tyr Thr 

        355                 360                 365             





Met Pro Ser Pro Leu Thr Ser Phe Ala His Thr Lys Thr Val Thr Ser 

    370                 375                 380                 





Ser Ala Val Cys Val Ser Pro Asp His Asp Ile Tyr Leu Ala Ala Gln 

385                 390                 395                 400 





Pro Arg Lys Asp Leu Trp Val Tyr Lys Pro Ala Gln Asn Ser Trp Gln 

                405                 410                 415     





Gln Leu Ala Asp Arg Leu Leu Cys Arg Glu Gly Met Asp Val Ala Tyr 

            420                 425                 430         





Leu Asn Gly Tyr Ile Tyr Ile Leu Gly Gly Arg Asp Pro Ile Thr Gly 

        435                 440                 445             





Val Lys Leu Lys Glu Val Glu Cys Tyr Ser Val Gln Arg Asn Gln Trp 

    450                 455                 460                 





Ala Leu Val Ala Pro Val Pro His Ser Phe Tyr Ser Phe Glu Leu Ile 

465                 470                 475                 480 





Val Val Gln Asn Tyr Leu Tyr Ala Val Asn Ser Lys Arg Met Leu Cys 

                485                 490                 495     





Tyr Asp Pro Ser His Asn Met Trp Leu Asn Cys Ala Ser Leu Lys Arg 

            500                 505                 510         





Ser Asp Phe Gln Glu Ala Cys Val Phe Asn Asp Glu Ile Tyr Cys Ile 

        515                 520                 525             





Cys Asp Ile Pro Val Met Lys Val Tyr Asn Pro Ala Arg Gly Glu Trp 

    530                 535                 540                 





Arg Arg Ile Ser Asn Ile Pro Leu Asp Ser Glu Thr His Asn Tyr Gln 

545                 550                 555                 560 





Ile Val Asn His Asp Gln Lys Leu Leu Leu Ile Thr Ser Thr Thr Pro 

                565                 570                 575     





Gln Trp Lys Lys Asn Arg Val Thr Val Tyr Glu Tyr Asp Thr Arg Glu 

            580                 585                 590         





Asp Gln Trp Ile Asn Ile Gly Thr Met Leu Gly Leu Leu Gln Phe Asp 

        595                 600                 605             





Ser Gly Phe Ile Cys Leu Cys Ala Arg Val Tyr Pro Ser Cys Leu Glu 

    610                 615                 620                 





Pro Gly Gln Ser Phe Ile Thr Glu Glu Asp Asp Ala Arg Ser Glu Ser 

625                 630                 635                 640 





Ser Thr Glu Trp Asp Leu Asp Gly Phe Ser Glu Leu Asp Ser Glu Ser 

                645                 650                 655     





Gly Ser Ser Ser Ser Phe Ser Asp Asp Glu Val Trp Val Gln Val Ala 

            660                 665                 670         





Pro Gln Arg Asn Ala Gln Asp Gln Gln Gly Ser Leu 

        675                 680                 





<210>  144

<211>  2735

<212>  DNA

<213>  Homo sapiens



<400>  144

atgggcatcc agggcatgga gctgtgcgcc atggccgtgg tggtgctgct gttcatcgcc       60



gtcctcaagc agttcggcat cctggagccc atatccatgg aagatagcag cgacagtgag      120



ctggagctgt ccacggtgcg ccaccagcca gaggggctgg accagctgca ggcccagacc      180



aagttcacca agaaggagct gcagtctctc tacaggggct ttaagaatga gtgtcccacg      240



ggcctggtgg acgaagacac cttcaaactc atttacgcgc agttcttccc tcagggagat      300



gccaccacct atgcacactt cctcttcaac gcctttgatg cggacgggaa cggggccatc      360



cactttgagg actttgtggt tggcctctcc atcctgctgc ggggcacagt ccacgagaag      420



ctcaagtggg cctttaatct ctacgacatt aacaaggatg gctacatcac caaagaggag      480



atgctggcca tcatgaagtc catctatgac atgatgggcc gccacaccta ccccatcctg      540



cgggaggacg cgccggcgga gcacgtggag aggttcttcg agaaaatgga ccggaaccag      600



gatggggtag tgaccattga agagttcctg gaggcctgtc agaaggatga gaacatcatg      660



agctccatgc agctgtttga gaatgtcatc taggacacgt ccaaaggagt gcatggccac      720



agccacctcc acccccaaga aacctccatc ctgccaggag cagcctccaa gaaactttta      780



aaaaatagat ttgcaaaaag tgaacagatt gctacacaca cacacacaca cacacacaca      840



cacacacaca gccattcatc tgggctggca gaggggacag agttcaggga ggggctgagt      900



ctggctaggg gccgagtcca ggagccccag ccagcccttc ccaggccagc gaggcgaggc      960



tgcctctggg tgagtggctg acagagcagg tctgcaggcc accagctgct ggatgtcacc     1020



aagaaggggc tcgagtgccc ctgcagggga gggtccaatc tccggtgtga gcccacctcg     1080



tcccgttctc cattctgctt tcttgccaca cagtgggccg gccccaggct cccctggtct     1140



cctccccgta gccactctct gcccactacc tatgcttcta gaaagcccct cacctcagga     1200



ccccagaggg accagctggg gggcaggggg gagagggggt aatggaggcc aagcctgcag     1260



ctttctggaa attcttccct gggggtccca ggatcccctg ctactccact gacctggaag     1320



agctgggtac caggccaccc actgtggggc aagcctgagt ggtgaggggc cactgggccc     1380



cattctccct ccatggcagg aaggcggggg atttcaagtt tagggattgg gtcgtggtgg     1440



agaatctgag ggcactctct gccagctcca cagggtggga tgagcctctc cttgccccag     1500



tcctggttca gtgggaatgc agtgggtggg gctgtacaca ccctccagca cagactgttc     1560



cctccaaggt cctcttaggt cccgggagga acgtggttca gagactggca gccagggagc     1620



ccggggcaga gctcagagga gtctgggaag gggcgtgtcc ctcctcttcc tgtagtgccc     1680



ctcccatggc ccagcagctt ggctgagccc cctctcctga agcagtgtcg ccgtccctct     1740



gccttgcaca aaaagcacaa gcattcctta gcagctcagg cgcagcccta gtgggagccc     1800



agcacactgc ttctcggagg ccaggccctc ctgctggctg aggcttgggc ccagtagccc     1860



caatatggtg gccctgggga agaggccttg ggggtctgct ctgtgcctgg gatcagtggg     1920



gccccaaagc ccagcccggc tgaccaacat tcaaaagcac aaaccctggg gactctgctt     1980



ggctgtcccc tccatctggg gatggagaat gccagcccaa agctggagcc aatggtgagg     2040



gctgagaggg ctgtggctgg gtggtcagca gaaaccccca ggaggagaga gatgctgctc     2100



ccgcctgatt ggggcctcac ccagaaggaa cccggtccca ggccgcatgg cccctccagg     2160



aacattccca cataatacat tccatcacag ccagcccagc tccactcagg gctggcccgg     2220



ggagtccccg tgtgccccaa gaggctagcc ccagggtgag cagggccctc agaggaaagg     2280



cagtatggcg gaggccatgg gggcccctcg gcattcacac acagcctggc ctcccctgcg     2340



gagctgcatg gacgcctggc tccaggctcc aggctgactg ggggcctctg cctccaggag     2400



ggcatcagct ttccctggct cagggatctt ctccctcccc tcacccgctg cccagccctc     2460



ccagctggtg tcactctgcc tctaaggcca aggcctcagg agagcatcac caccacaccc     2520



ctgccggcct tggccttggg gccagactgg ctgcacagcc caaccaggag gggtctgcct     2580



cccacgctgg gacacagacc ggccgcatgt ctgcatggca gaagcgtctc ccttggccac     2640



ggcctgggag ggtggttcct gttctcagca tccactaata ttcagtcctg tatattttaa     2700



taaaataaac ttgacaaagg aaaaaaaaaa aaaaa                                2735





<210>  145

<211>  230

<212>  PRT

<213>  Homo sapiens



<400>  145



Met Gly Ile Gln Gly Met Glu Leu Cys Ala Met Ala Val Val Val Leu 

1               5                   10                  15      





Leu Phe Ile Ala Val Leu Lys Gln Phe Gly Ile Leu Glu Pro Ile Ser 

            20                  25                  30          





Met Glu Asp Ser Ser Asp Ser Glu Leu Glu Leu Ser Thr Val Arg His 

        35                  40                  45              





Gln Pro Glu Gly Leu Asp Gln Leu Gln Ala Gln Thr Lys Phe Thr Lys 

    50                  55                  60                  





Lys Glu Leu Gln Ser Leu Tyr Arg Gly Phe Lys Asn Glu Cys Pro Thr 

65                  70                  75                  80  





Gly Leu Val Asp Glu Asp Thr Phe Lys Leu Ile Tyr Ala Gln Phe Phe 

                85                  90                  95      





Pro Gln Gly Asp Ala Thr Thr Tyr Ala His Phe Leu Phe Asn Ala Phe 

            100                 105                 110         





Asp Ala Asp Gly Asn Gly Ala Ile His Phe Glu Asp Phe Val Val Gly 

        115                 120                 125             





Leu Ser Ile Leu Leu Arg Gly Thr Val His Glu Lys Leu Lys Trp Ala 

    130                 135                 140                 





Phe Asn Leu Tyr Asp Ile Asn Lys Asp Gly Tyr Ile Thr Lys Glu Glu 

145                 150                 155                 160 





Met Leu Ala Ile Met Lys Ser Ile Tyr Asp Met Met Gly Arg His Thr 

                165                 170                 175     





Tyr Pro Ile Leu Arg Glu Asp Ala Pro Ala Glu His Val Glu Arg Phe 

            180                 185                 190         





Phe Glu Lys Met Asp Arg Asn Gln Asp Gly Val Val Thr Ile Glu Glu 

        195                 200                 205             





Phe Leu Glu Ala Cys Gln Lys Asp Glu Asn Ile Met Ser Ser Met Gln 

    210                 215                 220                 





Leu Phe Glu Asn Val Ile 

225                 230 





<210>  146

<211>  2928

<212>  DNA

<213>  Homo sapiens



<400>  146

gacaattacg tctgggtcca agcaaacatg aggcagctgc cagccggcct gggcagtctt       60



gtctgcctcg gctgtgaagt ggggaggctg gcaacagttt tcttcagcgc ccaggatgca      120



gccggctaag gaagtgacaa aggcgtcgga cggcagcctc ctgggggacc tcgggcacac      180



accacttagc aagaaggagg gtatcaagtg gcagaggccg aggctcagcc gccaggcttt      240



gatgagatgc tgcctggtca agtggatcct gtccagcaca gccccacagg gctcagatag      300



cagcgacagt gagctggagc tgtccacggt gcgccaccag ccagaggggc tggaccagct      360



gcaggcccag accaagttca ccaagaagga gctgcagtct ctctacaggg gctttaagaa      420



tgagtgtccc acgggcctgg tggacgaaga caccttcaaa ctcatttacg cgcagttctt      480



ccctcaggga gatgccacca cctatgcaca cttcctcttc aacgcctttg atgcggacgg      540



gaacggggcc atccactttg aggactttgt ggttggcctc tccatcctgc tgcggggcac      600



agtccacgag aagctcaagt gggcctttaa tctctacgac attaacaagg atggctacat      660



caccaaagag gagatgctgg ccatcatgaa gtccatctat gacatgatgg gccgccacac      720



ctaccccatc ctgcgggagg acgcgccggc ggagcacgtg gagaggttct tcgagaaaat      780



ggaccggaac caggatgggg tagtgaccat tgaagagttc ctggaggcct gtcagaagga      840



tgagaacatc atgagctcca tgcagctgtt tgagaatgtc atctaggaca cgtccaaagg      900



agtgcatggc cacagccacc tccaccccca agaaacctcc atcctgccag gagcagcctc      960



caagaaactt ttaaaaaata gatttgcaaa aagtgaacag attgctacac acacacacac     1020



acacacacac acacacacac acagccattc atctgggctg gcagagggga cagagttcag     1080



ggaggggctg agtctggcta ggggccgagt ccaggagccc cagccagccc ttcccaggcc     1140



agcgaggcga ggctgcctct gggtgagtgg ctgacagagc aggtctgcag gccaccagct     1200



gctggatgtc accaagaagg ggctcgagtg cccctgcagg ggagggtcca atctccggtg     1260



tgagcccacc tcgtcccgtt ctccattctg ctttcttgcc acacagtggg ccggccccag     1320



gctcccctgg tctcctcccc gtagccactc tctgcccact acctatgctt ctagaaagcc     1380



cctcacctca ggaccccaga gggaccagct ggggggcagg ggggagaggg ggtaatggag     1440



gccaagcctg cagctttctg gaaattcttc cctgggggtc ccaggatccc ctgctactcc     1500



actgacctgg aagagctggg taccaggcca cccactgtgg ggcaagcctg agtggtgagg     1560



ggccactggg ccccattctc cctccatggc aggaaggcgg gggatttcaa gtttagggat     1620



tgggtcgtgg tggagaatct gagggcactc tctgccagct ccacagggtg ggatgagcct     1680



ctccttgccc cagtcctggt tcagtgggaa tgcagtgggt ggggctgtac acaccctcca     1740



gcacagactg ttccctccaa ggtcctctta ggtcccggga ggaacgtggt tcagagactg     1800



gcagccaggg agcccggggc agagctcaga ggagtctggg aaggggcgtg tccctcctct     1860



tcctgtagtg cccctcccat ggcccagcag cttggctgag ccccctctcc tgaagcagtg     1920



tcgccgtccc tctgccttgc acaaaaagca caagcattcc ttagcagctc aggcgcagcc     1980



ctagtgggag cccagcacac tgcttctcgg aggccaggcc ctcctgctgg ctgaggcttg     2040



ggcccagtag ccccaatatg gtggccctgg ggaagaggcc ttgggggtct gctctgtgcc     2100



tgggatcagt ggggccccaa agcccagccc ggctgaccaa cattcaaaag cacaaaccct     2160



ggggactctg cttggctgtc ccctccatct ggggatggag aatgccagcc caaagctgga     2220



gccaatggtg agggctgaga gggctgtggc tgggtggtca gcagaaaccc ccaggaggag     2280



agagatgctg ctcccgcctg attggggcct cacccagaag gaacccggtc ccaggccgca     2340



tggcccctcc aggaacattc ccacataata cattccatca cagccagccc agctccactc     2400



agggctggcc cggggagtcc ccgtgtgccc caagaggcta gccccagggt gagcagggcc     2460



ctcagaggaa aggcagtatg gcggaggcca tgggggcccc tcggcattca cacacagcct     2520



ggcctcccct gcggagctgc atggacgcct ggctccaggc tccaggctga ctgggggcct     2580



ctgcctccag gagggcatca gctttccctg gctcagggat cttctccctc ccctcacccg     2640



ctgcccagcc ctcccagctg gtgtcactct gcctctaagg ccaaggcctc aggagagcat     2700



caccaccaca cccctgccgg ccttggcctt ggggccagac tggctgcaca gcccaaccag     2760



gaggggtctg cctcccacgc tgggacacag accggccgca tgtctgcatg gcagaagcgt     2820



ctcccttggc cacggcctgg gagggtggtt cctgttctca gcatccacta atattcagtc     2880



ctgtatattt taataaaata aacttgacaa aggaaaaaaa aaaaaaaa                  2928





<210>  147

<211>  256

<212>  PRT

<213>  Homo sapiens



<400>  147



Met Gln Pro Ala Lys Glu Val Thr Lys Ala Ser Asp Gly Ser Leu Leu 

1               5                   10                  15      





Gly Asp Leu Gly His Thr Pro Leu Ser Lys Lys Glu Gly Ile Lys Trp 

            20                  25                  30          





Gln Arg Pro Arg Leu Ser Arg Gln Ala Leu Met Arg Cys Cys Leu Val 

        35                  40                  45              





Lys Trp Ile Leu Ser Ser Thr Ala Pro Gln Gly Ser Asp Ser Ser Asp 

    50                  55                  60                  





Ser Glu Leu Glu Leu Ser Thr Val Arg His Gln Pro Glu Gly Leu Asp 

65                  70                  75                  80  





Gln Leu Gln Ala Gln Thr Lys Phe Thr Lys Lys Glu Leu Gln Ser Leu 

                85                  90                  95      





Tyr Arg Gly Phe Lys Asn Glu Cys Pro Thr Gly Leu Val Asp Glu Asp 

            100                 105                 110         





Thr Phe Lys Leu Ile Tyr Ala Gln Phe Phe Pro Gln Gly Asp Ala Thr 

        115                 120                 125             





Thr Tyr Ala His Phe Leu Phe Asn Ala Phe Asp Ala Asp Gly Asn Gly 

    130                 135                 140                 





Ala Ile His Phe Glu Asp Phe Val Val Gly Leu Ser Ile Leu Leu Arg 

145                 150                 155                 160 





Gly Thr Val His Glu Lys Leu Lys Trp Ala Phe Asn Leu Tyr Asp Ile 

                165                 170                 175     





Asn Lys Asp Gly Tyr Ile Thr Lys Glu Glu Met Leu Ala Ile Met Lys 

            180                 185                 190         





Ser Ile Tyr Asp Met Met Gly Arg His Thr Tyr Pro Ile Leu Arg Glu 

        195                 200                 205             





Asp Ala Pro Ala Glu His Val Glu Arg Phe Phe Glu Lys Met Asp Arg 

    210                 215                 220                 





Asn Gln Asp Gly Val Val Thr Ile Glu Glu Phe Leu Glu Ala Cys Gln 

225                 230                 235                 240 





Lys Asp Glu Asn Ile Met Ser Ser Met Gln Leu Phe Glu Asn Val Ile 

                245                 250                 255     





<210>  148

<211>  1303

<212>  DNA

<213>  Homo sapiens



<400>  148

gtgggacgcg cgcggctgtg agcctgcggg acatgccccc cgcgccggct ccttgctggc       60



ggccatgaag aggcagaacg tgcggactct gtccctcatc gtctgcacct tcacctacct      120



gctggtgggc gccgccgtgt tcgacgccct cgagtcggac cacgagatgc gcgaggagga      180



gaaactcaaa gccgaggaga tccggatcaa ggggaagtac aacatcagca gcgaggacta      240



ccggcagctg gagctggtga tcctgcagtc ggaaccgcac cgcgccggcg tccagtggaa      300



attcgccggc tccttctact ttgcgatcac ggtcatcacc accataggtt atgggcacgc      360



tgcacctggc accgatgcgg gcaaggcctt ctgcatgttc tacgccgtgc tgggcatccc      420



gctgacactg gtcatgttcc agagcctggg cgagcgcatg aacaccttcg tgcgctacct      480



gctgaagcgc attaagaagt gctgtggcat gcgcaacact gacgtgtcta tggagaacat      540



ggtgactgtg ggcttcttct cctgcatggg gacgctgtgc atcggggcgg ccgccttctc      600



ccagtgtgag gagtggagct tcttccacgc ctactactac tgcttcatca cgttgactac      660



cattgggttc ggggactacg tggccctgca gaccaagggt gccctgcaga agaagccgct      720



ctacgtggcc tttagcttta tgtatatcct ggtggggctg acggtcatcg gggccttcct      780



caacctggtc gtcctcaggt tcttgaccat gaacagtgag gatgagcggc gggatgctga      840



agagagggca tccctcgccg gaaaccgcaa cagcatggtc attcacatcc ctgaggagcc      900



gcggcccagc cggcccaggt acaaggcgga cgtcccggac ctgcagtctg tgtgctcctg      960



cacctgctac cgctcgcagg actatggcgg ccgctcggtg gcaccgcaga actccttcag     1020



cgccaagctt gccccccact acttccactc catctcttac aagatcgagg agatctcacc     1080



aagcacatta aaaaacagcc tcttcccatc gcctattagc tccatctctc ctgggttaca     1140



cagctttacc gaccaccaga ggctgatgaa acgccggaag tccgtttagg ggaactaact     1200



gcacattcaa gagaggcgtc cgtggatgct gggtctcact gccaaagccg aacacggctt     1260



cgggatttct gccttctcaa gtggacctct gctgtgctgg gcg                       1303





<210>  149

<211>  374

<212>  PRT

<213>  Homo sapiens



<400>  149



Met Lys Arg Gln Asn Val Arg Thr Leu Ser Leu Ile Val Cys Thr Phe 

1               5                   10                  15      





Thr Tyr Leu Leu Val Gly Ala Ala Val Phe Asp Ala Leu Glu Ser Asp 

            20                  25                  30          





His Glu Met Arg Glu Glu Glu Lys Leu Lys Ala Glu Glu Ile Arg Ile 

        35                  40                  45              





Lys Gly Lys Tyr Asn Ile Ser Ser Glu Asp Tyr Arg Gln Leu Glu Leu 

    50                  55                  60                  





Val Ile Leu Gln Ser Glu Pro His Arg Ala Gly Val Gln Trp Lys Phe 

65                  70                  75                  80  





Ala Gly Ser Phe Tyr Phe Ala Ile Thr Val Ile Thr Thr Ile Gly Tyr 

                85                  90                  95      





Gly His Ala Ala Pro Gly Thr Asp Ala Gly Lys Ala Phe Cys Met Phe 

            100                 105                 110         





Tyr Ala Val Leu Gly Ile Pro Leu Thr Leu Val Met Phe Gln Ser Leu 

        115                 120                 125             





Gly Glu Arg Met Asn Thr Phe Val Arg Tyr Leu Leu Lys Arg Ile Lys 

    130                 135                 140                 





Lys Cys Cys Gly Met Arg Asn Thr Asp Val Ser Met Glu Asn Met Val 

145                 150                 155                 160 





Thr Val Gly Phe Phe Ser Cys Met Gly Thr Leu Cys Ile Gly Ala Ala 

                165                 170                 175     





Ala Phe Ser Gln Cys Glu Glu Trp Ser Phe Phe His Ala Tyr Tyr Tyr 

            180                 185                 190         





Cys Phe Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr Val Ala Leu 

        195                 200                 205             





Gln Thr Lys Gly Ala Leu Gln Lys Lys Pro Leu Tyr Val Ala Phe Ser 

    210                 215                 220                 





Phe Met Tyr Ile Leu Val Gly Leu Thr Val Ile Gly Ala Phe Leu Asn 

225                 230                 235                 240 





Leu Val Val Leu Arg Phe Leu Thr Met Asn Ser Glu Asp Glu Arg Arg 

                245                 250                 255     





Asp Ala Glu Glu Arg Ala Ser Leu Ala Gly Asn Arg Asn Ser Met Val 

            260                 265                 270         





Ile His Ile Pro Glu Glu Pro Arg Pro Ser Arg Pro Arg Tyr Lys Ala 

        275                 280                 285             





Asp Val Pro Asp Leu Gln Ser Val Cys Ser Cys Thr Cys Tyr Arg Ser 

    290                 295                 300                 





Gln Asp Tyr Gly Gly Arg Ser Val Ala Pro Gln Asn Ser Phe Ser Ala 

305                 310                 315                 320 





Lys Leu Ala Pro His Tyr Phe His Ser Ile Ser Tyr Lys Ile Glu Glu 

                325                 330                 335     





Ile Ser Pro Ser Thr Leu Lys Asn Ser Leu Phe Pro Ser Pro Ile Ser 

            340                 345                 350         





Ser Ile Ser Pro Gly Leu His Ser Phe Thr Asp His Gln Arg Leu Met 

        355                 360                 365             





Lys Arg Arg Lys Ser Val 

    370                 





<210>  150

<211>  2562

<212>  DNA

<213>  Homo sapiens



<400>  150

gggaggagaa gcctgggtgc cccccactga taagcaggct ccacccagag gccagtcctg       60



tgtgtctggg gacaaggcga aagagcagca gaagtgcccc ttctccagga tcaaggaact      120



ggggcggggg gtgtttcctg gaccccagtc ctccgaatca gctcctagag tggaaccagg      180



aaggattctg gagccacaga agatagacag atggaaggtg gggaccaaag tgaggaagag      240



ccgagggaac gcagccaggc aggtggaatg ggaactctct ggagccaaga gagcactcca      300



gaagagaggc tgcccgtgga agggagcagg ccatgggcag tggccaggcg ggtgctgaca      360



gctatcctga ttttgggcct gctcctttgt ttttctgtgc ttttgttcta caacttccag      420



aactgtggcc ctcgcccctg tgagacatct gtgtgtttgg atctccggga tcattacctg      480



gcctctggga acacaagtgt ggccccctgc accgacttct tcagctttgc ctgtggaagg      540



gccaaagaga ccaataattc ttttcaggag cttgccacaa agaacaaaaa ccgacttcgg      600



agaatactgg aggtccagaa ttcctggcac ccaggctctg gggaggagaa agccttccag      660



ttctacaact cctgcatgga tacacttgcc attgaagctg cagggactgg tcccctcaga      720



caagttattg aggagcttgg aggctggcgc atctctggta aatggacttc cttaaacttt      780



aaccgaacgc tgagacttct gatgagtcag tatggccatt tccctttctt cagagcctac      840



ctaggacctc atcctgcctc tccacacaca ccagtcatcc agatagacca gccagagttt      900



gatgttcccc tcaagcaaga tcaagaacag aagatctatg cccagatctt tcgggaatac      960



ctgacttacc tgaatcagct gggaaccttg ctgggaggag acccaagcaa ggtgcaagaa     1020



cactcttcct tgtcaatctc catcacttca cggctgttcc agtttctgag gcccctggag     1080



cagcggcggg cacagggcaa gctcttccag atggtcacta tcgaccagct caaggaaatg     1140



gcccccgcca tcgactggtt gtcctgcttg caagcgacat tcacaccgat gtccctgagc     1200



ccttctcagt ccctcgtggt ccatgacgtg gaatatttga aaaacatgtc acaactggtg     1260



gaggagatgc tgctaaagca gagggacttt ctgcagagcc acatgatctt agggctggtg     1320



gtgacccttt ctccagccct ggacagtcaa ttccaggagg cacgcagaaa gctcagccag     1380



aaactgcggg aactgacaga gcaaccaccc atgcctgccc gcccacgatg gatgaagtgc     1440



gtggaggaga caggcacgtt cttcgagccc acgctggcgg ctttgtttgt tcgtgaggcc     1500



tttggcccga gcacccgaag tgctgccatg aaattattca ctgcgatccg ggatgccctc     1560



atcactcgcc tcagaaacct tccctggatg aatgaggaga cccagaacat ggcccaggac     1620



aaggttgctc aactgcaggt ggagatgggg gcttcagaat gggccctgaa gccagagctg     1680



gcccgacaag aatacaacga tatacagctt ggatcgagct tcctgcagtc tgtcctgagc     1740



tgtgtccggt ccctccgagc tagaattgtc cagagcttct tgcagcctca cccccaacac     1800



aggtggaagg tgtccccttg ggacgtcaat gcttactatt cggtatctga ccatgtggta     1860



gtctttccag ctggactcct ccaaccccca ttcttccacc ctggctatcc cagagccgtg     1920



aactttggcg ctgctggcag catcatggcc cacgagctgt tgcacatctt ctaccagctc     1980



ttactgcctg ggggctgcct cgcctgtgac aaccatgccc tccaggaagc tcacctgtgc     2040



ctgaagcgcc attatgctgc ctttccatta cctagcagaa cctccttcaa tgactccctc     2100



acattcttag agaatgctgc agacgttggg gggctagcca tcgcgctgca ggcatacagc     2160



aagaggctgt tacggcacca tggggagact gtcctgccca gcctggacct cagcccccag     2220



cagatcttct ttcgaagcta tgcccaggtg atgtgtagga agcccagccc ccaggactct     2280



cacgacactc acagccctcc acacctccga gtccacgggc ccctcagcag caccccagcc     2340



tttgccaggt atttccgctg tgcacgtggt gctctcttga acccctccag ccgctgccag     2400



ctctggtaac ttggttacca aagatgccac agcacagaaa tatcgaccaa cacctccctg     2460



gtcacatcca tggaatcaga gcaagatttc ctttctgctt ctgttccaaa aataaaagct     2520



ggcacttggc ttccgcttgt ctcttaaaaa aaaaaaaaaa aa                        2562





<210>  151

<211>  732

<212>  PRT

<213>  Homo sapiens



<400>  151



Met Glu Gly Gly Asp Gln Ser Glu Glu Glu Pro Arg Glu Arg Ser Gln 

1               5                   10                  15      





Ala Gly Gly Met Gly Thr Leu Trp Ser Gln Glu Ser Thr Pro Glu Glu 

            20                  25                  30          





Arg Leu Pro Val Glu Gly Ser Arg Pro Trp Ala Val Ala Arg Arg Val 

        35                  40                  45              





Leu Thr Ala Ile Leu Ile Leu Gly Leu Leu Leu Cys Phe Ser Val Leu 

    50                  55                  60                  





Leu Phe Tyr Asn Phe Gln Asn Cys Gly Pro Arg Pro Cys Glu Thr Ser 

65                  70                  75                  80  





Val Cys Leu Asp Leu Arg Asp His Tyr Leu Ala Ser Gly Asn Thr Ser 

                85                  90                  95      





Val Ala Pro Cys Thr Asp Phe Phe Ser Phe Ala Cys Gly Arg Ala Lys 

            100                 105                 110         





Glu Thr Asn Asn Ser Phe Gln Glu Leu Ala Thr Lys Asn Lys Asn Arg 

        115                 120                 125             





Leu Arg Arg Ile Leu Glu Val Gln Asn Ser Trp His Pro Gly Ser Gly 

    130                 135                 140                 





Glu Glu Lys Ala Phe Gln Phe Tyr Asn Ser Cys Met Asp Thr Leu Ala 

145                 150                 155                 160 





Ile Glu Ala Ala Gly Thr Gly Pro Leu Arg Gln Val Ile Glu Glu Leu 

                165                 170                 175     





Gly Gly Trp Arg Ile Ser Gly Lys Trp Thr Ser Leu Asn Phe Asn Arg 

            180                 185                 190         





Thr Leu Arg Leu Leu Met Ser Gln Tyr Gly His Phe Pro Phe Phe Arg 

        195                 200                 205             





Ala Tyr Leu Gly Pro His Pro Ala Ser Pro His Thr Pro Val Ile Gln 

    210                 215                 220                 





Ile Asp Gln Pro Glu Phe Asp Val Pro Leu Lys Gln Asp Gln Glu Gln 

225                 230                 235                 240 





Lys Ile Tyr Ala Gln Ile Phe Arg Glu Tyr Leu Thr Tyr Leu Asn Gln 

                245                 250                 255     





Leu Gly Thr Leu Leu Gly Gly Asp Pro Ser Lys Val Gln Glu His Ser 

            260                 265                 270         





Ser Leu Ser Ile Ser Ile Thr Ser Arg Leu Phe Gln Phe Leu Arg Pro 

        275                 280                 285             





Leu Glu Gln Arg Arg Ala Gln Gly Lys Leu Phe Gln Met Val Thr Ile 

    290                 295                 300                 





Asp Gln Leu Lys Glu Met Ala Pro Ala Ile Asp Trp Leu Ser Cys Leu 

305                 310                 315                 320 





Gln Ala Thr Phe Thr Pro Met Ser Leu Ser Pro Ser Gln Ser Leu Val 

                325                 330                 335     





Val His Asp Val Glu Tyr Leu Lys Asn Met Ser Gln Leu Val Glu Glu 

            340                 345                 350         





Met Leu Leu Lys Gln Arg Asp Phe Leu Gln Ser His Met Ile Leu Gly 

        355                 360                 365             





Leu Val Val Thr Leu Ser Pro Ala Leu Asp Ser Gln Phe Gln Glu Ala 

    370                 375                 380                 





Arg Arg Lys Leu Ser Gln Lys Leu Arg Glu Leu Thr Glu Gln Pro Pro 

385                 390                 395                 400 





Met Pro Ala Arg Pro Arg Trp Met Lys Cys Val Glu Glu Thr Gly Thr 

                405                 410                 415     





Phe Phe Glu Pro Thr Leu Ala Ala Leu Phe Val Arg Glu Ala Phe Gly 

            420                 425                 430         





Pro Ser Thr Arg Ser Ala Ala Met Lys Leu Phe Thr Ala Ile Arg Asp 

        435                 440                 445             





Ala Leu Ile Thr Arg Leu Arg Asn Leu Pro Trp Met Asn Glu Glu Thr 

    450                 455                 460                 





Gln Asn Met Ala Gln Asp Lys Val Ala Gln Leu Gln Val Glu Met Gly 

465                 470                 475                 480 





Ala Ser Glu Trp Ala Leu Lys Pro Glu Leu Ala Arg Gln Glu Tyr Asn 

                485                 490                 495     





Asp Ile Gln Leu Gly Ser Ser Phe Leu Gln Ser Val Leu Ser Cys Val 

            500                 505                 510         





Arg Ser Leu Arg Ala Arg Ile Val Gln Ser Phe Leu Gln Pro His Pro 

        515                 520                 525             





Gln His Arg Trp Lys Val Ser Pro Trp Asp Val Asn Ala Tyr Tyr Ser 

    530                 535                 540                 





Val Ser Asp His Val Val Val Phe Pro Ala Gly Leu Leu Gln Pro Pro 

545                 550                 555                 560 





Phe Phe His Pro Gly Tyr Pro Arg Ala Val Asn Phe Gly Ala Ala Gly 

                565                 570                 575     





Ser Ile Met Ala His Glu Leu Leu His Ile Phe Tyr Gln Leu Leu Leu 

            580                 585                 590         





Pro Gly Gly Cys Leu Ala Cys Asp Asn His Ala Leu Gln Glu Ala His 

        595                 600                 605             





Leu Cys Leu Lys Arg His Tyr Ala Ala Phe Pro Leu Pro Ser Arg Thr 

    610                 615                 620                 





Ser Phe Asn Asp Ser Leu Thr Phe Leu Glu Asn Ala Ala Asp Val Gly 

625                 630                 635                 640 





Gly Leu Ala Ile Ala Leu Gln Ala Tyr Ser Lys Arg Leu Leu Arg His 

                645                 650                 655     





His Gly Glu Thr Val Leu Pro Ser Leu Asp Leu Ser Pro Gln Gln Ile 

            660                 665                 670         





Phe Phe Arg Ser Tyr Ala Gln Val Met Cys Arg Lys Pro Ser Pro Gln 

        675                 680                 685             





Asp Ser His Asp Thr His Ser Pro Pro His Leu Arg Val His Gly Pro 

    690                 695                 700                 





Leu Ser Ser Thr Pro Ala Phe Ala Arg Tyr Phe Arg Cys Ala Arg Gly 

705                 710                 715                 720 





Ala Leu Leu Asn Pro Ser Ser Arg Cys Gln Leu Trp 

                725                 730         





<210>  152

<211>  6283

<212>  DNA

<213>  Homo sapiens



<400>  152

gagtagtact gccggttggt cagggttcgg cctcaacatg gcggttccgg ccgggcagtg       60



accaaggttt tgccgtccga aggactaagt ggtgactgtc ggcgtctcca cctatcgggg      120



tggaatgcga gcacgcgggg acgagcgctg agaagcggcg gtgacgggaa ggggggggtc      180



agtggattgt gccccagaaa ccgaagcggc ggcgtctgtt ccttcttgtt tctaggctcc      240



agtgcgttcg gggccccgcc cggccgggcc aggccggcgg gcggcggcgg tagctgctgc      300



agccgcagga taacctcgca gggtgggccg gagggcgggc gccgccgctg cctgtgctgc      360



ggcgatggcc cagtgtgtac aatcagtgca ggagctaatc ccggactcct tcgtcccctg      420



tgtcgctgcg ctgtgcagcg acgaagccga gcggctcact cgtctcaatc acctcagctt      480



cgcggagctg cttaagccct tctcccgcct cacttccgag gttcacatga gagatcctaa      540



taatcaactt cacgtaatta aaaatttgaa gatagcagta agcaacattg tcacccagcc      600



acctcagcct ggagccatcc ggaagctttt gaatgatgtt gtttctggca gtcagcctgc      660



agaaggatta gtagctaatg tgattacagc aggagattat gaccttaaca tcagtgccac      720



tactccatgg tttgagtctt acagagaaac ctttcttcag tcgatgccag catcggatca      780



tgaatttctg aaccactatt tagcatgtat gttggtagcg tcatctagtg aagctgaacc      840



tgtggaacag ttttcaaagt tgtcacaaga acagcatcga attcagcaca acagtgatta      900



ttcctacccc aagtggttta taccaaatac acttaaatac tatgtacttt tacatgatgt      960



aagtgcagga gatgaacaga gagctgaatc aatttatgaa gaaatgaaac agaaatatgg     1020



aactcagggt tgctatttac ttaaaattaa ttctcgaaca tctaatcgag catcagatga     1080



acagatacca gatccttgga gtcagtatct ccagaaaaat agtattcaaa accaggaatc     1140



atatgaagat ggcccttgta ctataacttc aaataagaat tctgataata acttgctttc     1200



attggatgga ttagataacg aagtcaaaga tggcttacca aataacttta gagctcaccc     1260



acttcagttg gagcaatcca gtgacccttc taacagtatt gatggcccag atcatctaag     1320



atctgcttca tcgttacatg aaacaaagaa aggaaatact ggaataattc atggtgcatg     1380



tttaacactt actgatcatg atagaattcg acagtttata caagagttca catttcgggg     1440



ccttttgcca catatagaga aaacaattag gcaattaaac gatcagctaa tatcaagaaa     1500



aggtttgagt cgatctctat tttctgcaac taaaaaatgg tttagtggca gtaaagttcc     1560



agaaaagagc attaatgacc tgaaaaatac atctggcttg ctgtatccgc cggaagcacc     1620



agaacttcaa atcaggaaaa tggctgactt atgttttttg gtgcagcatt atgatttggc     1680



ttacagttgc tatcatactg caaagaaaga ttttcttaat gatcaagcaa tgctttatgc     1740



agctggtgcc ttggaaatgg cagcagtgtc tgcttttctt caaccaggag cacctaggcc     1800



atatcctgct cattacatgg atacagcaat tcagacatac agagatatct gcaagaatat     1860



ggtgttggct gaaagatgtg tgttgcttag tgctgaactt ttaaaaagcc aaagcaaata     1920



ttcagaggct gcagctctcc taatacggtt gaccagtgag gattctgatc ttcgaagtgc     1980



acttcttttg gaacaggcag cacattgctt tataaacatg aaaagtccca tggttagaaa     2040



atatgcattt catatgatat tggcaggcca tcgatttagt aaagcagggc agaaaaagca     2100



tgctttacgc tgttattgtc aagccatgca agtttacaaa ggaaaaggct ggtctcttgc     2160



agaggatcac attaatttca ctattgggcg ccagtcctat actcttagac agctggataa     2220



tgctgtgtct gcttttaggc atattctaat taatgaaagt aaacaatctg ctgctcaaca     2280



gggggctttc ctcagagaat atctttatgt ttacaagaat gtaagtcagc tgtcaccaga     2340



tggtcctttg ccacagcttc ctttaccgta tattaacagt tcagcaacac gggttttttt     2400



tggccatgac agacgaccag cggatggtga aaaacaagca gctactcatg taagtcttga     2460



tcaagaatat gattctgaat cctctcagca gtggcgagaa cttgaggaac aagttgtttc     2520



tgtggttaac aaaggagtaa ttccatccaa ttttcatccc acacaatact gtttgaacag     2580



ttactcagat aattcaagat ttccacttgc agttgtagaa gaaccaatta cagtggaagt     2640



ggcttttaga aaccctttga aagttctact tttgttgact gatttgtcat tgctttggaa     2700



gtttcatcct aaagatttca gtggaaagga taatgaagaa gttaaacaac tagttacaag     2760



tgaacctgaa atgattggag ctgaagttat ttcagagttc ttaattaatg gcgaagaatc     2820



aaaagtggca agactaaagc tctttcccca tcacataggg gagctgcata ttctgggagt     2880



tgtttataat cttggcacta ttcagggctc tatgacagta gatggcattg gtgctcttcc     2940



cggatgtcac acaggaaaat attccttgag tatgtcagtc cgagggaagc aggatttaga     3000



aattcaaggt cctcgactta acaacacaaa agaagagaaa acatctgtta aatatggccc     3060



tgatcgacgt ttagatccca taatcacaga agaaatgcca ctgttggagg tgttctttat     3120



acattttcct acagggcttc tctgtggaga aatccgaaaa gcatatgtag aatttgtcaa     3180



tgtcagcaaa tgtccactta ctggattgaa ggttgtttct aaacgtccag agttctttac     3240



tttcggtggt aatactgctg ttctaacacc actaagtccc tcagcttctg agaattgtag     3300



tgcttacaag actgttgtga cagatgctac ctctgtgtgt acagcactca tatcatcagc     3360



ttcttctgta gactttggca ttggcacagg aagtcaacca gaggtgattc ctgttcccct     3420



tcctgacact gttcttctac ccggagcctc agtgcagctg ccaatgtggt tacgtgggcc     3480



tgatgaagaa ggtgtccatg aaattaactt tttgttttac tatgaaagtg tcaaaaagca     3540



gccaaaaata cggcacagaa tattaagaca cactgcaatt atttgtacca gtcggtcttt     3600



aaatgtacgg gccactgtct gcagaagtaa ttctcttgaa aatgaagaag gcagaggagg     3660



caatatgcta gtctttgtgg atgtggaaaa taccaatact agtgaagcag gcgttaagga     3720



attccacata gtgcaagtat caagtagtag caaacactgg aagttacaga aatctgtaaa     3780



tctttctgaa aacaaagata ccaaacttgc cagtagggag aagggaaagt tttgctttaa     3840



ggcaataaga tgtgagaaag aagaagcggc cacacagtcc tctgaaaaat atacctttgc     3900



agatatcatc tttggaaatg aacagataat aagttcagca agcccatgtg cagacttctt     3960



ttatcgaagt ttatcttctg aattgaaaaa accacaagct cacttgcctg tgcatacaga     4020



aaaacagtca acagaggatg ctgtgagatt gattcaaaaa tgcagtgagg tagatttgaa     4080



tattgtcata ttatggaagg catacgttgt ggaagacagt aaacagctta ttttggaagg     4140



tcaacatcat gttattcttc gcactatagg aaaagaagcc ttttcatatc ctcagaaaca     4200



ggagccacca gaaatggaac tattgaaatt tttcaggcca gaaaacatta cagtttcctc     4260



aaggccatca gtagagcagc tttctagtct cattaaaacg agtcttcact acccagaatc     4320



atttaatcat ccatttcatc aaaaaagcct ttgtttagta ccagtcactc ttttactttc     4380



caattgttct aaggctgatg tagatgtcat agttgatctt cggcataaaa caacaagtcc     4440



agaagcactg gaaatccatg gatcattcac atggcttgga caaacacagt ataaacttca     4500



acttaaaagc caggagattc acagtctgca gctgaaagca tgctttgttc atacaggtgt     4560



ttataacctt ggaactccta gggtatttgc caagttatcg gaccaagtta cagtgtttga     4620



aacaagtcag cagaattcca tgcctgccct gatcatcatc agtaatgtgt gacaacttgg     4680



aaatttgtac tgaaatccac aataatcagt ttttgctgga tgggttttac agcagtattt     4740



gatataccta acttgttatg gaggttgatt gatatctgat ccctgcaaaa tactttgact     4800



tgtcattttg ttgatgatgc aaagcacgtt ggactgagaa tacttaacat tctttttctg     4860



tatttcttta aaccctgaga ataatttaca tgctcataat acaggatatc agcatatttg     4920



tgcaccttat taagccccat cttaagaaaa cacaaagtct aagtctgctg ttacaacttg     4980



tcaatggtat acgaatatta ggagatgatt ctgagaaagg aaaggccttg ttggcagtac     5040



tcctgttaag ccattagtct ctaaattcca gctttactgt gaagttctat agagtgttaa     5100



atacaaattt tcctgtcttg cttcacacag ttccttaaaa tcagttttga actttggtca     5160



tagagtcttc atatttcagt atttggtggt ccctatgact tatacataac tttgtaaaaa     5220



gaaaaaaaaa ttttttctga tgctttgaat atagttttga aaggagtttt gacttttttc     5280



ccctcattca tctcagtata gagtgcgcta tttcacaata cgatttttgt cattaaaatt     5340



accatattct ttattatata acgttaacta ttgagttgat ctgtttaaaa tataaatctc     5400



aagttaatta aaaataagct tttcaaaaat gtattatatt tataacaaat atactgtaaa     5460



tagaataaag acatgctatt cactgtatag cgtattagta tctgttgatt agaaagtctg     5520



gtttcaaaat atttttttat tcagagaatg ggcatttgga cataagaaat ttcaattcag     5580



ccctgctgca gatagagaaa tgggagcaag gttgtttcaa tgaatatctc ttgtcattgg     5640



agaaggaggg aagacagggt gtaggagtgg gtggcaggga gtacaagagc cagggtcagt     5700



caagtctgga gcagatgggg tccttgtgcc attgacagct accatggttt gttccagtct     5760



caatctcggc actaatcgga gcagactgca ccaaagtggg gagagatcaa aagaccccgt     5820



tttcagactg aagattccaa acctgtactt ggaacaactc ttcttgagag atgggtggct     5880



agtctgtgtg cctctctgca actgctgctt atgcttctgg atcttaagtg ggtctctggc     5940



ttttcagctc cttccactct gtgtcttagc aggtgtggga caagttggag aggaaggtca     6000



cattctaagg acactcattt ccttcttgag agtttagggc catgggctta taaaaagtct     6060



gaggaggaaa gacaagaatg aggaggcata atcacagtgg tatctcatat ttaaaccact     6120



cagctgaata ttaaattgaa ccgattgtta aacagacact aataaaaaaa ttaaactata     6180



taaacctaca actgaatata ttaaaaataa aggtaataaa gcactcaaaa ttacttcctg     6240



aatattactc aggaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                       6283





<210>  153

<211>  1435

<212>  PRT

<213>  Homo sapiens



<400>  153



Met Ala Gln Cys Val Gln Ser Val Gln Glu Leu Ile Pro Asp Ser Phe 

1               5                   10                  15      





Val Pro Cys Val Ala Ala Leu Cys Ser Asp Glu Ala Glu Arg Leu Thr 

            20                  25                  30          





Arg Leu Asn His Leu Ser Phe Ala Glu Leu Leu Lys Pro Phe Ser Arg 

        35                  40                  45              





Leu Thr Ser Glu Val His Met Arg Asp Pro Asn Asn Gln Leu His Val 

    50                  55                  60                  





Ile Lys Asn Leu Lys Ile Ala Val Ser Asn Ile Val Thr Gln Pro Pro 

65                  70                  75                  80  





Gln Pro Gly Ala Ile Arg Lys Leu Leu Asn Asp Val Val Ser Gly Ser 

                85                  90                  95      





Gln Pro Ala Glu Gly Leu Val Ala Asn Val Ile Thr Ala Gly Asp Tyr 

            100                 105                 110         





Asp Leu Asn Ile Ser Ala Thr Thr Pro Trp Phe Glu Ser Tyr Arg Glu 

        115                 120                 125             





Thr Phe Leu Gln Ser Met Pro Ala Ser Asp His Glu Phe Leu Asn His 

    130                 135                 140                 





Tyr Leu Ala Cys Met Leu Val Ala Ser Ser Ser Glu Ala Glu Pro Val 

145                 150                 155                 160 





Glu Gln Phe Ser Lys Leu Ser Gln Glu Gln His Arg Ile Gln His Asn 

                165                 170                 175     





Ser Asp Tyr Ser Tyr Pro Lys Trp Phe Ile Pro Asn Thr Leu Lys Tyr 

            180                 185                 190         





Tyr Val Leu Leu His Asp Val Ser Ala Gly Asp Glu Gln Arg Ala Glu 

        195                 200                 205             





Ser Ile Tyr Glu Glu Met Lys Gln Lys Tyr Gly Thr Gln Gly Cys Tyr 

    210                 215                 220                 





Leu Leu Lys Ile Asn Ser Arg Thr Ser Asn Arg Ala Ser Asp Glu Gln 

225                 230                 235                 240 





Ile Pro Asp Pro Trp Ser Gln Tyr Leu Gln Lys Asn Ser Ile Gln Asn 

                245                 250                 255     





Gln Glu Ser Tyr Glu Asp Gly Pro Cys Thr Ile Thr Ser Asn Lys Asn 

            260                 265                 270         





Ser Asp Asn Asn Leu Leu Ser Leu Asp Gly Leu Asp Asn Glu Val Lys 

        275                 280                 285             





Asp Gly Leu Pro Asn Asn Phe Arg Ala His Pro Leu Gln Leu Glu Gln 

    290                 295                 300                 





Ser Ser Asp Pro Ser Asn Ser Ile Asp Gly Pro Asp His Leu Arg Ser 

305                 310                 315                 320 





Ala Ser Ser Leu His Glu Thr Lys Lys Gly Asn Thr Gly Ile Ile His 

                325                 330                 335     





Gly Ala Cys Leu Thr Leu Thr Asp His Asp Arg Ile Arg Gln Phe Ile 

            340                 345                 350         





Gln Glu Phe Thr Phe Arg Gly Leu Leu Pro His Ile Glu Lys Thr Ile 

        355                 360                 365             





Arg Gln Leu Asn Asp Gln Leu Ile Ser Arg Lys Gly Leu Ser Arg Ser 

    370                 375                 380                 





Leu Phe Ser Ala Thr Lys Lys Trp Phe Ser Gly Ser Lys Val Pro Glu 

385                 390                 395                 400 





Lys Ser Ile Asn Asp Leu Lys Asn Thr Ser Gly Leu Leu Tyr Pro Pro 

                405                 410                 415     





Glu Ala Pro Glu Leu Gln Ile Arg Lys Met Ala Asp Leu Cys Phe Leu 

            420                 425                 430         





Val Gln His Tyr Asp Leu Ala Tyr Ser Cys Tyr His Thr Ala Lys Lys 

        435                 440                 445             





Asp Phe Leu Asn Asp Gln Ala Met Leu Tyr Ala Ala Gly Ala Leu Glu 

    450                 455                 460                 





Met Ala Ala Val Ser Ala Phe Leu Gln Pro Gly Ala Pro Arg Pro Tyr 

465                 470                 475                 480 





Pro Ala His Tyr Met Asp Thr Ala Ile Gln Thr Tyr Arg Asp Ile Cys 

                485                 490                 495     





Lys Asn Met Val Leu Ala Glu Arg Cys Val Leu Leu Ser Ala Glu Leu 

            500                 505                 510         





Leu Lys Ser Gln Ser Lys Tyr Ser Glu Ala Ala Ala Leu Leu Ile Arg 

        515                 520                 525             





Leu Thr Ser Glu Asp Ser Asp Leu Arg Ser Ala Leu Leu Leu Glu Gln 

    530                 535                 540                 





Ala Ala His Cys Phe Ile Asn Met Lys Ser Pro Met Val Arg Lys Tyr 

545                 550                 555                 560 





Ala Phe His Met Ile Leu Ala Gly His Arg Phe Ser Lys Ala Gly Gln 

                565                 570                 575     





Lys Lys His Ala Leu Arg Cys Tyr Cys Gln Ala Met Gln Val Tyr Lys 

            580                 585                 590         





Gly Lys Gly Trp Ser Leu Ala Glu Asp His Ile Asn Phe Thr Ile Gly 

        595                 600                 605             





Arg Gln Ser Tyr Thr Leu Arg Gln Leu Asp Asn Ala Val Ser Ala Phe 

    610                 615                 620                 





Arg His Ile Leu Ile Asn Glu Ser Lys Gln Ser Ala Ala Gln Gln Gly 

625                 630                 635                 640 





Ala Phe Leu Arg Glu Tyr Leu Tyr Val Tyr Lys Asn Val Ser Gln Leu 

                645                 650                 655     





Ser Pro Asp Gly Pro Leu Pro Gln Leu Pro Leu Pro Tyr Ile Asn Ser 

            660                 665                 670         





Ser Ala Thr Arg Val Phe Phe Gly His Asp Arg Arg Pro Ala Asp Gly 

        675                 680                 685             





Glu Lys Gln Ala Ala Thr His Val Ser Leu Asp Gln Glu Tyr Asp Ser 

    690                 695                 700                 





Glu Ser Ser Gln Gln Trp Arg Glu Leu Glu Glu Gln Val Val Ser Val 

705                 710                 715                 720 





Val Asn Lys Gly Val Ile Pro Ser Asn Phe His Pro Thr Gln Tyr Cys 

                725                 730                 735     





Leu Asn Ser Tyr Ser Asp Asn Ser Arg Phe Pro Leu Ala Val Val Glu 

            740                 745                 750         





Glu Pro Ile Thr Val Glu Val Ala Phe Arg Asn Pro Leu Lys Val Leu 

        755                 760                 765             





Leu Leu Leu Thr Asp Leu Ser Leu Leu Trp Lys Phe His Pro Lys Asp 

    770                 775                 780                 





Phe Ser Gly Lys Asp Asn Glu Glu Val Lys Gln Leu Val Thr Ser Glu 

785                 790                 795                 800 





Pro Glu Met Ile Gly Ala Glu Val Ile Ser Glu Phe Leu Ile Asn Gly 

                805                 810                 815     





Glu Glu Ser Lys Val Ala Arg Leu Lys Leu Phe Pro His His Ile Gly 

            820                 825                 830         





Glu Leu His Ile Leu Gly Val Val Tyr Asn Leu Gly Thr Ile Gln Gly 

        835                 840                 845             





Ser Met Thr Val Asp Gly Ile Gly Ala Leu Pro Gly Cys His Thr Gly 

    850                 855                 860                 





Lys Tyr Ser Leu Ser Met Ser Val Arg Gly Lys Gln Asp Leu Glu Ile 

865                 870                 875                 880 





Gln Gly Pro Arg Leu Asn Asn Thr Lys Glu Glu Lys Thr Ser Val Lys 

                885                 890                 895     





Tyr Gly Pro Asp Arg Arg Leu Asp Pro Ile Ile Thr Glu Glu Met Pro 

            900                 905                 910         





Leu Leu Glu Val Phe Phe Ile His Phe Pro Thr Gly Leu Leu Cys Gly 

        915                 920                 925             





Glu Ile Arg Lys Ala Tyr Val Glu Phe Val Asn Val Ser Lys Cys Pro 

    930                 935                 940                 





Leu Thr Gly Leu Lys Val Val Ser Lys Arg Pro Glu Phe Phe Thr Phe 

945                 950                 955                 960 





Gly Gly Asn Thr Ala Val Leu Thr Pro Leu Ser Pro Ser Ala Ser Glu 

                965                 970                 975     





Asn Cys Ser Ala Tyr Lys Thr Val Val Thr Asp Ala Thr Ser Val Cys 

            980                 985                 990         





Thr Ala Leu Ile Ser Ser Ala Ser  Ser Val Asp Phe Gly  Ile Gly Thr 

        995                 1000                 1005             





Gly Ser  Gln Pro Glu Val Ile  Pro Val Pro Leu Pro  Asp Thr Val 

    1010                 1015                 1020             





Leu Leu  Pro Gly Ala Ser Val  Gln Leu Pro Met Trp  Leu Arg Gly 

    1025                 1030                 1035             





Pro Asp  Glu Glu Gly Val His  Glu Ile Asn Phe Leu  Phe Tyr Tyr 

    1040                 1045                 1050             





Glu Ser  Val Lys Lys Gln Pro  Lys Ile Arg His Arg  Ile Leu Arg 

    1055                 1060                 1065             





His Thr  Ala Ile Ile Cys Thr  Ser Arg Ser Leu Asn  Val Arg Ala 

    1070                 1075                 1080             





Thr Val  Cys Arg Ser Asn Ser  Leu Glu Asn Glu Glu  Gly Arg Gly 

    1085                 1090                 1095             





Gly Asn  Met Leu Val Phe Val  Asp Val Glu Asn Thr  Asn Thr Ser 

    1100                 1105                 1110             





Glu Ala  Gly Val Lys Glu Phe  His Ile Val Gln Val  Ser Ser Ser 

    1115                 1120                 1125             





Ser Lys  His Trp Lys Leu Gln  Lys Ser Val Asn Leu  Ser Glu Asn 

    1130                 1135                 1140             





Lys Asp  Thr Lys Leu Ala Ser  Arg Glu Lys Gly Lys  Phe Cys Phe 

    1145                 1150                 1155             





Lys Ala  Ile Arg Cys Glu Lys  Glu Glu Ala Ala Thr  Gln Ser Ser 

    1160                 1165                 1170             





Glu Lys  Tyr Thr Phe Ala Asp  Ile Ile Phe Gly Asn  Glu Gln Ile 

    1175                 1180                 1185             





Ile Ser  Ser Ala Ser Pro Cys  Ala Asp Phe Phe Tyr  Arg Ser Leu 

    1190                 1195                 1200             





Ser Ser  Glu Leu Lys Lys Pro  Gln Ala His Leu Pro  Val His Thr 

    1205                 1210                 1215             





Glu Lys  Gln Ser Thr Glu Asp  Ala Val Arg Leu Ile  Gln Lys Cys 

    1220                 1225                 1230             





Ser Glu  Val Asp Leu Asn Ile  Val Ile Leu Trp Lys  Ala Tyr Val 

    1235                 1240                 1245             





Val Glu  Asp Ser Lys Gln Leu  Ile Leu Glu Gly Gln  His His Val 

    1250                 1255                 1260             





Ile Leu  Arg Thr Ile Gly Lys  Glu Ala Phe Ser Tyr  Pro Gln Lys 

    1265                 1270                 1275             





Gln Glu  Pro Pro Glu Met Glu  Leu Leu Lys Phe Phe  Arg Pro Glu 

    1280                 1285                 1290             





Asn Ile  Thr Val Ser Ser Arg  Pro Ser Val Glu Gln  Leu Ser Ser 

    1295                 1300                 1305             





Leu Ile  Lys Thr Ser Leu His  Tyr Pro Glu Ser Phe  Asn His Pro 

    1310                 1315                 1320             





Phe His  Gln Lys Ser Leu Cys  Leu Val Pro Val Thr  Leu Leu Leu 

    1325                 1330                 1335             





Ser Asn  Cys Ser Lys Ala Asp  Val Asp Val Ile Val  Asp Leu Arg 

    1340                 1345                 1350             





His Lys  Thr Thr Ser Pro Glu  Ala Leu Glu Ile His  Gly Ser Phe 

    1355                 1360                 1365             





Thr Trp  Leu Gly Gln Thr Gln  Tyr Lys Leu Gln Leu  Lys Ser Gln 

    1370                 1375                 1380             





Glu Ile  His Ser Leu Gln Leu  Lys Ala Cys Phe Val  His Thr Gly 

    1385                 1390                 1395             





Val Tyr  Asn Leu Gly Thr Pro  Arg Val Phe Ala Lys  Leu Ser Asp 

    1400                 1405                 1410             





Gln Val  Thr Val Phe Glu Thr  Ser Gln Gln Asn Ser  Met Pro Ala 

    1415                 1420                 1425             





Leu Ile  Ile Ile Ser Asn Val  

    1430                 1435 





<210>  154

<211>  5431

<212>  DNA

<213>  Homo sapiens



<400>  154

agtcgggagg cttagctggg gccgcagcgc ggcggcaaca tcactctcgc tgccgctgct       60



ccgccccatc cccttctgtt tttctctctc attctccagt ggcggcggcg gggaaggcgg      120



aggcagaggc agcagcagcc gcgctggctg caatgaatga tcccccagct tggggggagg      180



actccaggtg agcctctgcc ctcgggaggc ccgggacccc cggccgccca cgaccggcag      240



cccacgctat ggatccctag aggaaggagg agaagacagc tcgccgccca cccccatccc      300



attttcctct tcctttatct cattgttgcc gaagctgttt acggcagcgc tccctctgct      360



ccagcatggg gcgggctccg ggcacggctg ctcggcaggc gctgctcccg cggcgactgg      420



gggattctgc ctaattcacc tcccagccgg tgcagagagg accggagagc ggtggaggcc      480



cggactgcag cagcgttggg gccacctccc agcgtcccca ccctaggagg ctgcatgcgg      540



attgaagagc tgcgcctggg ggctgggccg gccccgctga tcccgaccta gcgagcagga      600



tagcaggacc gcccaggctg cggaggggct cgggggcagg aaggtcagag cagcaagatg      660



gccagtaaga ccaaggccag cgaggccctc aaggtggtgg cccggtgccg ccccctcagc      720



aggaaggagg aggctgctgg tcacgagcag atcctgacca tggacgtgaa actgggccag      780



gtgaccctgc ggaacccccg cgccgccccg ggggagctgc ccaagacctt cacctttgac      840



gccgtgtatg atgccagctc caagcaggcc gacctgtatg acgaaaccgt gaggcccctg      900



atagactccg tgctccaggg tttcaatggc acggtgtttg cctatggcca gacgggcact      960



ggcaagacct ataccatgca ggggacctgg gtggagcccg agctgcgcgg ggtcatcccg     1020



aatgcctttg agcacatctt cacccacatc tcccgctccc agaaccaaca gtacctggtc     1080



cgggcctcct atttggagat ctaccaggaa gagattcgag acctgctctc caaggagccg     1140



ggcaagaggc tagagctgaa agagaacccc gagactggcg tctacatcaa ggacctctcc     1200



tccttcgtca ccaagaatgt caaggagatt gagcatgtga tgaacctggg gaaccagacc     1260



cgggctgtgg gcagcaccca catgaatgag gtcagctccc gctcccatgc catcttcatc     1320



atcactgtgg agtgcagcga acgtggctct gatggccagg accacatccg agtgggcaag     1380



ctcaacctcg tggacctggc tggcagcgag aggcagaaca aggcaggccc caacacagcg     1440



ggaggggcag ccacaccatc ctcgggtggc ggtggtggcg gtggaggcag tggtggtggt     1500



gctggtggag agaggcctaa ggaagcctcc aaaatcaacc tctcattatc tgccctgggc     1560



aacgtgattg ctgccctggc gggcaacagg agcacccaca ttccctaccg ggactccaag     1620



ctgacccggc tgctccagga ctccctgggg gggaatgcca agaccatcat ggtagccaca     1680



ctggggccag cttctcacag ctacgatgag agcctctcca ccttgcgctt tgccaaccga     1740



gccaagaaca tcaagaacaa gccccgggtg aacgaggacc ccaaggacac actgctgcgg     1800



gaattccaag aggagattgc ccgcctgaag gcccagctgg agaagagggg gatgctgggg     1860



aagcggcccc ggaggaagag cagccgcagg aagaaggccg tgtccgcccc gcctgggtac     1920



cctgagggcc cagtgattga ggcctgggtg gcagaagagg aggatgacaa caacaacaac     1980



caccgcccgc cccagcccat cctggagtca gccttggaga agaacatgga gaattacctg     2040



caggaacaga aggagcggct ggaggaggag aaggcagcca tccaggatga ccgcagcctg     2100



gtgagcgagg agaagcagaa gctgctggag gagaaggaga agatgctgga ggacctgcgg     2160



cgggaacagc aggccacaga gctgcttgcg gccaagtaca aggccatgga gagcaagctc     2220



ctcatcgggg gcaggaacat catggatcac accaacgaac agcagaagat gttggaactg     2280



aagaggcagg agattgccga gcagaaacgt cgtgagcggg agatgcagca ggagatgatg     2340



ctccgggacg aggagactat ggagctccgg ggcacctaca catccctgca gcaggaggtg     2400



gaggtcaaaa ccaagaaact caagaagctc tacgccaagc tgcaggcggt gaaggcggag     2460



atccaggacc agcatgatga gtatatccgc gtgcggcagg acctggagga ggcgcagaac     2520



gagcagaccc gcgaactcaa gctcaagtac ctaatcatcg agaacttcat cccgccggag     2580



gagaagaaca agatcatgaa ccggcttttc ctggactgtg aggaggagca gtggaagttc     2640



cagccactgg tgccagccgg cgtcagtagc agccagatga agaagcggcc aacatctgca     2700



gtgggctaca agaggcctat cagccagtat gctcgggttg ccatggcaat ggggtcccac     2760



cccaggtaca gggctgaaaa cataatgttt ctggagttgg atgtgtcccc tccagctgtc     2820



tttgagatgg aattctctca cgaccaagaa caagaccctc gtgcgctaca catggagagg     2880



ctcatgcgat tggacagctt tctggaaaga ccttccacgt ctaaagtccg aaagtccaga     2940



tcctggtgcc agagtcctca gcggcctcca ccttccacca cacatgcctc cctggcctct     3000



gcttctctgc gccctgcaac agtggcggac catgagtgac aaccatcacg tcaggctgcc     3060



catccaatag actcctggga tggggcagcc aaccctggct catctcatct gccgcttggt     3120



gcgtgtgcgt gtgcgtgcat gtgcgtgtgc gtgtgtgcag gggtgagaat ctggcagatg     3180



gtgcctctgc ctgctcttct tcgcctcctt tatttaattc atgttattta ttcgcggagc     3240



tctgttcgtg ttggggagat gccctcgcct gagccgtctg ggcctaccgt ggtcactgcg     3300



tagcctcttt ttcttctgac ttgagagctc ccccagtcag atctcaggct tgtccccctg     3360



tcagctgcct ccagaaggga aggtagccag tgcctgagaa gacagtccct tttctaccca     3420



ccgcactcca taacctccat cttctcccac actgatggcg agcagcccct gagcactttc     3480



tgggactggg agactgcttg gtgttccctg aggacaagag acatcctgac agtgttgggc     3540



atctgctccc cgtggacaca gccccactct ccactttctg agcctcagac aacctcattc     3600



agcctcttgg gctccttttc aaggacatta ataacctcac caacatagct catgcccttc     3660



agctttgaca agaactcaca gcttcccaaa ctctgctttc tgcccacctt ggatgggaac     3720



tgtggaccaa gcaattacca tcgccttgga acctgcagga aatggaacag caattgagac     3780



aacttgaaca gtcatcaacg gaagtccctc cactggattc ctttgtttct gtcccctccg     3840



aggagtcatt ttggtcgaca ggctctcaag gcaactcccc attttcaaga ggctgctcct     3900



gcctgcttcg atcatttctc cctgcagctg cctagacccc gttcacagtg ggaggagtca     3960



atgtcattct acccctcgct aaacgaagat attaacatct attgcttttt cccttcatct     4020



gtcacaggaa acagaagccc aggcacaatc ttttccagct ttgcctgtta cccctgtttc     4080



tgaattgcat ctttaaggta ttattttgtt gacaatagat cctttattca ctagttacgc     4140



aaattggttc ctagggggat actccttacc ttcctttgtg atggcccaaa atgtctctag     4200



gtatctcaag tgataagtaa atttctacaa aaaaaaatgg ttaatgttca ttgactggct     4260



ttttaagtgt atattttgga ggacgggtga agaggtcata acgaaagcaa gcgagtgaat     4320



taggatttca aagtgcccta atagtgtgag tctccagttc ctagaatatg aagagtgctg     4380



tcgttggggt gaaaccatga gactgacaga tctgcctgaa atggggggtg tgggaggtgg     4440



tggcgggggt tattctcttt ccttcaggaa atgaaccctt cttacatcat tcaagttctg     4500



ctctgaggat caagcttggg tctgatttaa ctcagcgaca ctgtcatttc tgcttcatta     4560



ctggactaga gggttgagcc acccacttgc catttgctcc tgtccttcca ggaaatcaca     4620



attttcatca gagcccaaga gattatttga gactcaggat tcagatcaga ggttcgactg     4680



tggctgggac aggagttgtg tgtagaaatt caccaggtgg cctgagcgca gggggacctc     4740



cagggctgcg ttgagcagcc tctcccactg acctctttct cgtttgtgga caaagcagca     4800



cgtatcacct cattcatcac ttggacacat cgcctttgca ttgtcttgtc acacctccct     4860



cacagtctta tagcacaata tacccaaatc agccccccca gtccgagggc tgggcccaag     4920



gtatggtcgg aggaggagct cctgcctgcg gttttgtgta tgtgtgtatg tgtgtgcgtg     4980



tttgtgtgcg tgtttacctc cacaggggac actctacact cagtgtaaga tctgctggga     5040



acagggccac caggagtggc tggatctcag tctctctgtc tctctttctc tccttttcct     5100



tttggtgtat caaatatttg attgacaaag taagggcctt gattaggacc aaattctcgt     5160



gtgttgctat ggtctttatt taggacaaca attaacaatg cagtggccca ttcttgtcac     5220



tctacacata tgactatacg ggacatatgt aatatataaa tatatatata aaacattccc     5280



ctctgtcccc ttggcttcgg atggaggcct ttctgttgag ctgaaatgca cctgcagctg     5340



ggtgctgcca gcagcttgca ggccccagcc ctgttccaat caatgcagtt gacaataaag     5400



gaatgagtat cgtcacggag ttgactgcct t                                    5431





<210>  155

<211>  793

<212>  PRT

<213>  Homo sapiens



<400>  155



Met Ala Ser Lys Thr Lys Ala Ser Glu Ala Leu Lys Val Val Ala Arg 

1               5                   10                  15      





Cys Arg Pro Leu Ser Arg Lys Glu Glu Ala Ala Gly His Glu Gln Ile 

            20                  25                  30          





Leu Thr Met Asp Val Lys Leu Gly Gln Val Thr Leu Arg Asn Pro Arg 

        35                  40                  45              





Ala Ala Pro Gly Glu Leu Pro Lys Thr Phe Thr Phe Asp Ala Val Tyr 

    50                  55                  60                  





Asp Ala Ser Ser Lys Gln Ala Asp Leu Tyr Asp Glu Thr Val Arg Pro 

65                  70                  75                  80  





Leu Ile Asp Ser Val Leu Gln Gly Phe Asn Gly Thr Val Phe Ala Tyr 

                85                  90                  95      





Gly Gln Thr Gly Thr Gly Lys Thr Tyr Thr Met Gln Gly Thr Trp Val 

            100                 105                 110         





Glu Pro Glu Leu Arg Gly Val Ile Pro Asn Ala Phe Glu His Ile Phe 

        115                 120                 125             





Thr His Ile Ser Arg Ser Gln Asn Gln Gln Tyr Leu Val Arg Ala Ser 

    130                 135                 140                 





Tyr Leu Glu Ile Tyr Gln Glu Glu Ile Arg Asp Leu Leu Ser Lys Glu 

145                 150                 155                 160 





Pro Gly Lys Arg Leu Glu Leu Lys Glu Asn Pro Glu Thr Gly Val Tyr 

                165                 170                 175     





Ile Lys Asp Leu Ser Ser Phe Val Thr Lys Asn Val Lys Glu Ile Glu 

            180                 185                 190         





His Val Met Asn Leu Gly Asn Gln Thr Arg Ala Val Gly Ser Thr His 

        195                 200                 205             





Met Asn Glu Val Ser Ser Arg Ser His Ala Ile Phe Ile Ile Thr Val 

    210                 215                 220                 





Glu Cys Ser Glu Arg Gly Ser Asp Gly Gln Asp His Ile Arg Val Gly 

225                 230                 235                 240 





Lys Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Gln Asn Lys Ala 

                245                 250                 255     





Gly Pro Asn Thr Ala Gly Gly Ala Ala Thr Pro Ser Ser Gly Gly Gly 

            260                 265                 270         





Gly Gly Gly Gly Gly Ser Gly Gly Gly Ala Gly Gly Glu Arg Pro Lys 

        275                 280                 285             





Glu Ala Ser Lys Ile Asn Leu Ser Leu Ser Ala Leu Gly Asn Val Ile 

    290                 295                 300                 





Ala Ala Leu Ala Gly Asn Arg Ser Thr His Ile Pro Tyr Arg Asp Ser 

305                 310                 315                 320 





Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn Ala Lys Thr 

                325                 330                 335     





Ile Met Val Ala Thr Leu Gly Pro Ala Ser His Ser Tyr Asp Glu Ser 

            340                 345                 350         





Leu Ser Thr Leu Arg Phe Ala Asn Arg Ala Lys Asn Ile Lys Asn Lys 

        355                 360                 365             





Pro Arg Val Asn Glu Asp Pro Lys Asp Thr Leu Leu Arg Glu Phe Gln 

    370                 375                 380                 





Glu Glu Ile Ala Arg Leu Lys Ala Gln Leu Glu Lys Arg Gly Met Leu 

385                 390                 395                 400 





Gly Lys Arg Pro Arg Arg Lys Ser Ser Arg Arg Lys Lys Ala Val Ser 

                405                 410                 415     





Ala Pro Pro Gly Tyr Pro Glu Gly Pro Val Ile Glu Ala Trp Val Ala 

            420                 425                 430         





Glu Glu Glu Asp Asp Asn Asn Asn Asn His Arg Pro Pro Gln Pro Ile 

        435                 440                 445             





Leu Glu Ser Ala Leu Glu Lys Asn Met Glu Asn Tyr Leu Gln Glu Gln 

    450                 455                 460                 





Lys Glu Arg Leu Glu Glu Glu Lys Ala Ala Ile Gln Asp Asp Arg Ser 

465                 470                 475                 480 





Leu Val Ser Glu Glu Lys Gln Lys Leu Leu Glu Glu Lys Glu Lys Met 

                485                 490                 495     





Leu Glu Asp Leu Arg Arg Glu Gln Gln Ala Thr Glu Leu Leu Ala Ala 

            500                 505                 510         





Lys Tyr Lys Ala Met Glu Ser Lys Leu Leu Ile Gly Gly Arg Asn Ile 

        515                 520                 525             





Met Asp His Thr Asn Glu Gln Gln Lys Met Leu Glu Leu Lys Arg Gln 

    530                 535                 540                 





Glu Ile Ala Glu Gln Lys Arg Arg Glu Arg Glu Met Gln Gln Glu Met 

545                 550                 555                 560 





Met Leu Arg Asp Glu Glu Thr Met Glu Leu Arg Gly Thr Tyr Thr Ser 

                565                 570                 575     





Leu Gln Gln Glu Val Glu Val Lys Thr Lys Lys Leu Lys Lys Leu Tyr 

            580                 585                 590         





Ala Lys Leu Gln Ala Val Lys Ala Glu Ile Gln Asp Gln His Asp Glu 

        595                 600                 605             





Tyr Ile Arg Val Arg Gln Asp Leu Glu Glu Ala Gln Asn Glu Gln Thr 

    610                 615                 620                 





Arg Glu Leu Lys Leu Lys Tyr Leu Ile Ile Glu Asn Phe Ile Pro Pro 

625                 630                 635                 640 





Glu Glu Lys Asn Lys Ile Met Asn Arg Leu Phe Leu Asp Cys Glu Glu 

                645                 650                 655     





Glu Gln Trp Lys Phe Gln Pro Leu Val Pro Ala Gly Val Ser Ser Ser 

            660                 665                 670         





Gln Met Lys Lys Arg Pro Thr Ser Ala Val Gly Tyr Lys Arg Pro Ile 

        675                 680                 685             





Ser Gln Tyr Ala Arg Val Ala Met Ala Met Gly Ser His Pro Arg Tyr 

    690                 695                 700                 





Arg Ala Glu Asn Ile Met Phe Leu Glu Leu Asp Val Ser Pro Pro Ala 

705                 710                 715                 720 





Val Phe Glu Met Glu Phe Ser His Asp Gln Glu Gln Asp Pro Arg Ala 

                725                 730                 735     





Leu His Met Glu Arg Leu Met Arg Leu Asp Ser Phe Leu Glu Arg Pro 

            740                 745                 750         





Ser Thr Ser Lys Val Arg Lys Ser Arg Ser Trp Cys Gln Ser Pro Gln 

        755                 760                 765             





Arg Pro Pro Pro Ser Thr Thr His Ala Ser Leu Ala Ser Ala Ser Leu 

    770                 775                 780                 





Arg Pro Ala Thr Val Ala Asp His Glu 

785                 790             





<210>  156

<211>  1808

<212>  DNA

<213>  Homo sapiens



<400>  156

tccggagctc ggcgggcggc gtcagcggaa cgggcggctt ccggccgcgg cgtaaacaag       60



gccgtggact gcaggaggcg gggcagacgg gctgcaagag ggagccggcc cgacgcggac      120



cgcttccctg cagtgccccg agtcccgggc ccgcgccgcc gccgcccggc tccgctcgcg      180



gcccctctgt ctgcaggcgt gccccggcgg cggcggagag ccgtcctcgg ccgaggaggc      240



tgggaaacgc gagcgcaggc ggcagagagg cctcaacgcc gtccctttcg ccaccgcctt      300



ttccttgcct cgcgccgctg tgcatttctc tccttttcct ttgttttttt ggcccctcgc      360



gggtgtgggc attgttggtt agcaaaagtg cagcctcaag atggctgatg gcaacgagga      420



tctgcgggct gacgacttgc ctgggccagc cttcgagagc tatgagtcca tggagcttgc      480



ctgccccgct gagcgcagcg gccacgtagc cgtcagcgac gggcgccaca tgttcgtctg      540



gggcggctac aagagtaatc aagtcagagg attatatgac ttttatctgc ctagagaaga      600



actatggatc tacaacatgg agactggaag atggaaaaaa atcaacactg aaggtgatgt      660



tcctccttct atgtcaggaa gctgtgctgt gtgtgtagac agggtgctgt acttgtttgg      720



aggacaccat tcaagaggca ataccaataa gttctacatg ctggattcaa ggtctacaga      780



cagagtgtta cagtgggaaa gaattgattg ccaaggaatt cctccatcat caaaggacaa      840



acttggtgtc tgggtatata aaaacaagtt aatatttttt ggagggtatg gatatttgcc      900



tgaagataaa gtattgggaa cttttgaatt cgatgaaaca tctttttgga attcaagtca      960



tccaagagga tggaatgatc atgtacatat tttagatact gaaacattta cctggagcca     1020



gcctataact actggtaaag caccttcacc tcgtgctgcc catgcctgtg caactgtcgg     1080



aaatagaggc ttcgtgtttg gaggcagata tcgagatgct agaatgaatg atcttcacta     1140



tcttaatctg gatacatggg agtggaatga attaattcca caaggcatat gcccagttgg     1200



tcgatcttgg cactcactaa caccagtttc ttcagatcat ctttttctct ttggaggatt     1260



taccactgat aaacagccac taagtgatgc ctggacttac tgcatcagta aaaatgaatg     1320



gatacaattt aatcatccat ataccgaaaa accaaggtta tggcacacag cttgtgccag     1380



cgatgaagga gaagtaattg tttttggtgg atgtgccaac aacttgcttg tccatcacag     1440



agctgcacac agtaatgaaa tactaatatt ttcagttcaa ccaaaatctc ttgtacggct     1500



aagcttagaa gcagtcattt gctttaaaga aatgttagcc aactcatgga actgccttcc     1560



aaaacactta cttcacagtg ttaatcagag gtttggtagt aacaacactt ctggatctta     1620



aggcttcata aataatgcct atgatcacct tgcatggaca gcaatcctgt aaacatcaca     1680



gagtggcatc atttgtataa ttatatgcat tgttgtagtt tgcacctgtt ggttttaatg     1740



tgcatgtgaa tggcctagag aacctatttt tgtgtctaaa gtttacaata aatgtattta     1800



acaccaaa                                                              1808





<210>  157

<211>  406

<212>  PRT

<213>  Homo sapiens



<400>  157



Met Ala Asp Gly Asn Glu Asp Leu Arg Ala Asp Asp Leu Pro Gly Pro 

1               5                   10                  15      





Ala Phe Glu Ser Tyr Glu Ser Met Glu Leu Ala Cys Pro Ala Glu Arg 

            20                  25                  30          





Ser Gly His Val Ala Val Ser Asp Gly Arg His Met Phe Val Trp Gly 

        35                  40                  45              





Gly Tyr Lys Ser Asn Gln Val Arg Gly Leu Tyr Asp Phe Tyr Leu Pro 

    50                  55                  60                  





Arg Glu Glu Leu Trp Ile Tyr Asn Met Glu Thr Gly Arg Trp Lys Lys 

65                  70                  75                  80  





Ile Asn Thr Glu Gly Asp Val Pro Pro Ser Met Ser Gly Ser Cys Ala 

                85                  90                  95      





Val Cys Val Asp Arg Val Leu Tyr Leu Phe Gly Gly His His Ser Arg 

            100                 105                 110         





Gly Asn Thr Asn Lys Phe Tyr Met Leu Asp Ser Arg Ser Thr Asp Arg 

        115                 120                 125             





Val Leu Gln Trp Glu Arg Ile Asp Cys Gln Gly Ile Pro Pro Ser Ser 

    130                 135                 140                 





Lys Asp Lys Leu Gly Val Trp Val Tyr Lys Asn Lys Leu Ile Phe Phe 

145                 150                 155                 160 





Gly Gly Tyr Gly Tyr Leu Pro Glu Asp Lys Val Leu Gly Thr Phe Glu 

                165                 170                 175     





Phe Asp Glu Thr Ser Phe Trp Asn Ser Ser His Pro Arg Gly Trp Asn 

            180                 185                 190         





Asp His Val His Ile Leu Asp Thr Glu Thr Phe Thr Trp Ser Gln Pro 

        195                 200                 205             





Ile Thr Thr Gly Lys Ala Pro Ser Pro Arg Ala Ala His Ala Cys Ala 

    210                 215                 220                 





Thr Val Gly Asn Arg Gly Phe Val Phe Gly Gly Arg Tyr Arg Asp Ala 

225                 230                 235                 240 





Arg Met Asn Asp Leu His Tyr Leu Asn Leu Asp Thr Trp Glu Trp Asn 

                245                 250                 255     





Glu Leu Ile Pro Gln Gly Ile Cys Pro Val Gly Arg Ser Trp His Ser 

            260                 265                 270         





Leu Thr Pro Val Ser Ser Asp His Leu Phe Leu Phe Gly Gly Phe Thr 

        275                 280                 285             





Thr Asp Lys Gln Pro Leu Ser Asp Ala Trp Thr Tyr Cys Ile Ser Lys 

    290                 295                 300                 





Asn Glu Trp Ile Gln Phe Asn His Pro Tyr Thr Glu Lys Pro Arg Leu 

305                 310                 315                 320 





Trp His Thr Ala Cys Ala Ser Asp Glu Gly Glu Val Ile Val Phe Gly 

                325                 330                 335     





Gly Cys Ala Asn Asn Leu Leu Val His His Arg Ala Ala His Ser Asn 

            340                 345                 350         





Glu Ile Leu Ile Phe Ser Val Gln Pro Lys Ser Leu Val Arg Leu Ser 

        355                 360                 365             





Leu Glu Ala Val Ile Cys Phe Lys Glu Met Leu Ala Asn Ser Trp Asn 

    370                 375                 380                 





Cys Leu Pro Lys His Leu Leu His Ser Val Asn Gln Arg Phe Gly Ser 

385                 390                 395                 400 





Asn Asn Thr Ser Gly Ser 

                405     





<210>  158

<211>  570

<212>  DNA

<213>  Homo sapiens



<400>  158

actgaggggt cagtggttcc gggtaggagc taggtgaccc tcggctgctg cagggatctg       60



cagcgactgc agccatgggg gcccacctgg tccggcgcta cctgggcgat gcctcggtgg      120



agcccgaccc cctgcagatg ccaaccttcc cgccagacta cggcttcccc gaacgcaagg      180



agcgcgagat ggtggccaca cagcaggaga tgatggacgc gcagctgagg ctccagctgc      240



gggactactg cgcccaccac ctcatccggc tgctcaagtg caagcgtgac agcttcccca      300



acttcctggc ctgcaagcag gagcggcacg actgggacta ctgcgagcac cgcgactatg      360



tgatgcgcat gaaggagttt gagcgggagc ggaggctgct ccagcggaag aagcggcggg      420



agaagaaggc ggcagagttg gccaaaggcc agggacccgg ggaagtggac cccaaggtgg      480



ccctgtaggg ggtgcacccc ccaccctatg gaccagtcaa ataaaagcct tcaggcccct      540



caaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                       570





<210>  159

<211>  137

<212>  PRT

<213>  Homo sapiens



<400>  159



Met Gly Ala His Leu Val Arg Arg Tyr Leu Gly Asp Ala Ser Val Glu 

1               5                   10                  15      





Pro Asp Pro Leu Gln Met Pro Thr Phe Pro Pro Asp Tyr Gly Phe Pro 

            20                  25                  30          





Glu Arg Lys Glu Arg Glu Met Val Ala Thr Gln Gln Glu Met Met Asp 

        35                  40                  45              





Ala Gln Leu Arg Leu Gln Leu Arg Asp Tyr Cys Ala His His Leu Ile 

    50                  55                  60                  





Arg Leu Leu Lys Cys Lys Arg Asp Ser Phe Pro Asn Phe Leu Ala Cys 

65                  70                  75                  80  





Lys Gln Glu Arg His Asp Trp Asp Tyr Cys Glu His Arg Asp Tyr Val 

                85                  90                  95      





Met Arg Met Lys Glu Phe Glu Arg Glu Arg Arg Leu Leu Gln Arg Lys 

            100                 105                 110         





Lys Arg Arg Glu Lys Lys Ala Ala Glu Leu Ala Lys Gly Gln Gly Pro 

        115                 120                 125             





Gly Glu Val Asp Pro Lys Val Ala Leu 

    130                 135         





<210>  160

<211>  6046

<212>  DNA

<213>  Homo sapiens



<400>  160

tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc cacgcgcgcg cgtacgcgcc       60



cgatgcagcg cggccccgtg accctagtcg gccgctgaga ggcgcgcgga gtctgggccg      120



ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc tccggcccga atcccggagt      180



gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc ctccctgcag ccgtcagggc      240



ccgtccccca actccccttt ccgctcaggc agggtcctcg cggcccatgc tggccgctgg      300



ggacccgcgc agcccagacc gttcccgggc cgggcagccg gccaccatgg tggccctgag      360



gcctgtgcag caactccagg ggggctaaag ggctcagagt gcaggccgtg gggcgcgagg      420



gtcccgggcc tgagccccgc gccatggccg gggccatcgc ttcccgcatg agcttcagct      480



ctctcaagag gaagcaaccc aagacgttca ccgtgaggat cgtcaccatg gacgccgaga      540



tggagttcaa ttgcgagatg aagtggaaag ggaaggacct ctttgatttg gtgtgccgga      600



ctctggggct ccgagaaacc tggttctttg gactgcagta cacaatcaag gacacagtgg      660



cctggctcaa aatggacaag aaggtactgg atcatgatgt ttcaaaggaa gaaccagtca      720



cctttcactt cttggccaaa ttttatcctg agaatgctga agaggagctg gttcaggaga      780



tcacacaaca tttattcttc ttacaggtaa agaagcagat tttagatgaa aagatctact      840



gccctcctga ggcttctgtg ctcctggctt cttacgccgt ccaggccaag tatggtgact      900



acgaccccag tgttcacaag cggggatttt tggcccaaga ggaattgctt ccaaaaaggg      960



taataaatct gtatcagatg actccggaaa tgtgggagga gagaattact gcttggtacg     1020



cagagcaccg aggccgagcc agggatgaag ctgaaatgga atatctgaag atagctcagg     1080



acctggagat gtacggtgtg aactactttg caatccggaa taaaaagggc acagagctgc     1140



tgcttggagt ggatgccctg gggcttcaca tttatgaccc tgagaacaga ctgaccccca     1200



agatctcctt cccgtggaat gaaatccgaa acatctcgta cagtgacaag gagtttacta     1260



ttaaaccact ggataagaaa attgatgtct tcaagtttaa ctcctcaaag cttcgtgtta     1320



ataagctgat tctccagcta tgtatcggga accatgatct atttatgagg agaaggaaag     1380



ccgattcttt ggaagttcag cagatgaaag cccaggccag ggaggagaag gctagaaagc     1440



agatggagcg gcagcgcctc gctcgagaga agcagatgag ggaggaggct gaacgcacga     1500



gggatgagtt ggagaggagg ctgctgcaga tgaaagaaga agcaacaatg gccaacgaag     1560



cactgatgcg gtctgaggag acagctgacc tgttggctga aaaggcccag atcaccgagg     1620



aggaggcaaa acttctggcc cagaaggccg cagaggctga gcaggaaatg cagcgcatca     1680



aggccacagc gattcgcacg gaggaggaga agcgcctgat ggagcagaag gtgctggaag     1740



ccgaggtgct ggcactgaag atggctgagg agtcagagag gagggccaaa gaggcagatc     1800



agctgaagca ggacctgcag gaagcacgcg aggcggagcg aagagccaag cagaagctcc     1860



tggagattgc caccaagccc acgtacccgc ccatgaaccc aattccagca ccgttgcctc     1920



ctgacatacc aagcttcaac ctcattggtg acagcctgtc tttcgacttc aaagatactg     1980



acatgaagcg gctttccatg gagatagaga aagaaaaagt ggaatacatg gaaaagagca     2040



agcatctgca ggagcagctc aatgaactca agacagaaat cgaggccttg aaactgaaag     2100



agagggagac agctctggat attctgcaca atgagaactc cgacaggggt ggcagcagca     2160



agcacaatac cattaaaaag ctcaccttgc agagcgccaa gtcccgagtg gccttctttg     2220



aagagctcta gcaggtgacc cagccacccc aggacctgcc acttctcctg ctaccgggac     2280



cgcgggatgg accagatatc aagagagcca tccataggga gctggctggg ggtttccgtg     2340



ggagctccag aactttcccc agctgagtga agagcccagc ccctcttatg tgcaattgcc     2400



ttgaactacg accctgtaga gatttctctc atggcgttct agttctctga cctgagtctt     2460



tgttttaaga agtatttgtc ttcctttgtc taatgtggga ttcctgactc ccttcgtcca     2520



aggcaccggt gtgtgtgtgt cttgcactcc agagctgacc tccaccgccc agcctgggaa     2580



gtcattgtag ggagtgagac actgaagccc tgagaagcca gtgccatcat ccccaccccg     2640



cccagggttc cggaacattc attcccccac cggtgaggac ctggcatgca gcgaagcagc     2700



ccagcccggc ggatcccagg ccagcacgcc tgccggcttc tcatcgtcag ggagcccgcc     2760



cagagctcgt gacgagcaag tgctgggtcc ccgccaggca ccccgaggcg gcgctctggc     2820



tggcagctgg tggggaatag gcagggcagc tgtggctggg gagagacttt aggcagaagc     2880



tgtgatgcag gctgactgcc agccgagggg ctgggtagtg ccgtgcggga gctgatggta     2940



cagggcactc gctgtccccc tccggccacc ctagaccagg gtccgagagg caggcaggag     3000



ccactcatgt cttccccatt gcccgacgcc catagacgct ccttcctgtg tggggctggg     3060



gtactccctg gtcgtactgc agtcagcacc cgtaacccgg ctatgaccag ggatctgtaa     3120



gccctgtggc tccacaggtg ctgcttctca ctggcccaga ctctgagctc caccggccca     3180



gtctgcacgg cccatctgct tcaccttccc tcccagccac gtgccagtgg ccacagccca     3240



cttcccaacc cactgttgta cccaggcctc actttgctgt tgcccttgtc cctcttcggg     3300



ccctgaattt tctgttccct gggggccagc cagggccctt tgtgcccctc ccagcacagg     3360



cctgatgcag gtgtccactc acaggtggcg ctcacctagg ctgtcacagg acccacctcc     3420



atgccaggca acagagggcc acagaaccac ccccacggct cactccttgg tctggggcca     3480



ccttcttgcc ctttcttttt tttttttttt ttttttttcc gagatggagt ctctctctgt     3540



cacccaggtg ggagtgtggt ggcacaatct cggctcactg caacctccac ctcctgagtt     3600



caagcaattc tcctgcctca gcctcccaag tagctgggac tacaggcatg caccaccaca     3660



cttggccaat gttctgtatt tttaataggg acggggtttt gccatgttag ctaggctggt     3720



ctcaaactca cacctgggat tacaggcatg agccactgca cccagcccct tcttgccctt     3780



tcttttctcc atggctgatg ctgctgtggc cagccagggc ccttgagatc cttccagttt     3840



ggctgttatg caaagcaggt gatttgtctt aatcagataa aagatagagg ctatgggggc     3900



ctcaagattt ttggagagca gaggtggtct ctggcaattc catctggttt tgagaaactt     3960



agcagctcac agagcacaga gatcctgcct tcttcctact atcaggctga cctaatgggg     4020



ttgggctgct cggcaactgc ttgggtcacc ttgccccaag gaaaccagcc ctgggtgcca     4080



cccagccact tagggtctac agggtgggac tccagaccta gagcgtaagt atggatgttg     4140



tggccctgtg tcttcctagt gtgacccagc caggagcgga agcttcaggc gtttgtaaag     4200



tgaggtctgg ctctgcctcc tccgtttttt ttttttttct gtttctgttt ctgttttttt     4260



tttgagatgg agtctcgctc tgtcgcccag gctggagtgc agtgtcacga tctcagctca     4320



ctgcaacctc cgcctcccag gtacaagaga ttctcctgcc tcagcctccc gagtagctgg     4380



gactacaggc gtgtgccacc atgcctggct aatttttgta tttttagtag agatggggtt     4440



tcgccatgtt agccagactg gtctcgaact cctgacctca ggtgatcctc ccaccccggc     4500



ttcccaaagt tctgggatta taggcgtgag ccaccatgcc cggtctcttc tcagtcttga     4560



agcccatccc tggatttcca ccaggagtta ctttcctcct gacctgtaaa tttgttcttt     4620



aacaatggct gcaggtggga gcatatggtg gtttataaaa acgctgtcgg gctttgtttc     4680



cttctttagc tgccgtgtct acttctgaag tctgggaagt gccaagccac gcggcctcaa     4740



gggagctggc tggtgtttga gctgtggcag aagcacctgg ggctccaggg agcaggctgg     4800



gaactgcagg accttgctca gccaggagca cttccccctc cttgaggcag gaatactgag     4860



gtgcctcccc acagatggag aaggtggaga ggaggatggg cctcaggagc atctcaagcc     4920



ccagtagcag gagaaagaaa gaaagagatg cctggttttc acagactggt tcctgtggct     4980



gggatgactg catccttttt tttttttttt tgagacggag tttttgcctt tgtcgcccag     5040



gctggagtgc aatggcgtga tctcggctca ccgcaacctc cgcctcccgg attcaagcaa     5100



ttctcctgcc tcagcctccc gagtagctgg gattacaggc acgcacctcc acgtccggct     5160



aattttgtat ttttagtgga gacggggttt ctccatgtcg gtcaggctgg tctcgaactc     5220



ccgacctcag gtgatctgcc cacctcggcc tcccaaagtg ctgggattac aggcatgagc     5280



caccgcgctt ggccagactg cgtccttttt aagcgaacat tttagggcct gggagtttgt     5340



caagtaagga agtctcaagc ccaaagagca gcgtcctgac catggtggtt tcattacgag     5400



cccttctgct ggctctcagg cagaagcccc acagcaccgg gaccattcat gaggtcactg     5460



cccagctcat gatgtccgtg aggctgtcct tttggccagt agccgtgtgc agctgtgtgg     5520



cacagatggc ttcgttcatc ctgatcaagg ccccacctca gccacagcag tccccccaac     5580



ctgtgttgtc caccctatta ttcatgtacc tgccaggccc tgctagatag caccccgtgg     5640



cattacataa cacttcatga gtggctgtgt cttgtaattt tggggacagg tttctctctt     5700



tccctctctt ttttttgtca aaagcccaga gactgacaac cagctgcagt gtctaagtgt     5760



tcctcactga cagggtgggg cctcaccacc cctggaggga gcagcgttgg cagggagaca     5820



gcctggccca gtgaccctgg gcccaagcca gcccctccag ggctttcagg gaagcgccat     5880



ccattttcaa agatgtcaaa cgtcacttct tcctgtaggg cccgagtcct gcctcctatc     5940



agggccagat catagaaggc tattttctat tctggggaac gattataact taaatgattg     6000



ttttaataaa aattctaagc tggaaaataa aaaaaaaaaa aaaaaa                    6046





<210>  161

<211>  595

<212>  PRT

<213>  Homo sapiens



<400>  161



Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 

1               5                   10                  15      





Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 

            20                  25                  30          





Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp 

        35                  40                  45              





Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu 

    50                  55                  60                  





Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys 

65                  70                  75                  80  





Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe 

                85                  90                  95      





Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu 

            100                 105                 110         





Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp 

        115                 120                 125             





Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr 

    130                 135                 140                 





Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg 

145                 150                 155                 160 





Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu 

                165                 170                 175     





Tyr Gln Met Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr 

            180                 185                 190         





Ala Glu His Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu 

        195                 200                 205             





Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile 

    210                 215                 220                 





Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly 

225                 230                 235                 240 





Leu His Ile Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe 

                245                 250                 255     





Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr 

            260                 265                 270         





Ile Lys Pro Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser 

        275                 280                 285             





Lys Leu Arg Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His 

    290                 295                 300                 





Asp Leu Phe Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln 

305                 310                 315                 320 





Met Lys Ala Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg 

                325                 330                 335     





Gln Arg Leu Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr 

            340                 345                 350         





Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr 

        355                 360                 365             





Met Ala Asn Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu 

    370                 375                 380                 





Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln 

385                 390                 395                 400 





Lys Ala Ala Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala 

                405                 410                 415     





Ile Arg Thr Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu 

            420                 425                 430         





Ala Glu Val Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala 

        435                 440                 445             





Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala 

    450                 455                 460                 





Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr 

465                 470                 475                 480 





Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro 

                485                 490                 495     





Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr 

            500                 505                 510         





Asp Met Lys Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr 

        515                 520                 525             





Met Glu Lys Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr 

    530                 535                 540                 





Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile 

545                 550                 555                 560 





Leu His Asn Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr 

                565                 570                 575     





Ile Lys Lys Leu Thr Leu Gln Ser Ala Lys Ser Arg Val Ala Phe Phe 

            580                 585                 590         





Glu Glu Leu 

        595 





<210>  162

<211>  6091

<212>  DNA

<213>  Homo sapiens



<400>  162

tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc cacgcgcgcg cgtacgcgcc       60



cgatgcagcg cggccccgtg accctagtcg gccgctgaga ggcgcgcgga gtctgggccg      120



ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc tccggcccga atcccggagt      180



gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc ctccctgcag ccgtcagggc      240



ccgtccccca actccccttt ccgctcaggc agggtcctcg cggcccatgc tggccgctgg      300



ggacccgcgc agcccagacc gttcccgggc cgggcagccg gccaccatgg tggccctgag      360



gcctgtgcag caactccagg ggggctaaag ggctcagagt gcaggccgtg gggcgcgagg      420



gtcccgggcc tgagccccgc gccatggccg gggccatcgc ttcccgcatg agcttcagct      480



ctctcaagag gaagcaaccc aagacgttca ccgtgaggat cgtcaccatg gacgccgaga      540



tggagttcaa ttgcgagatg aagtggaaag ggaaggacct ctttgatttg gtgtgccgga      600



ctctggggct ccgagaaacc tggttctttg gactgcagta cacaatcaag gacacagtgg      660



cctggctcaa aatggacaag aaggtactgg atcatgatgt ttcaaaggaa gaaccagtca      720



cctttcactt cttggccaaa ttttatcctg agaatgctga agaggagctg gttcaggaga      780



tcacacaaca tttattcttc ttacaggtaa agaagcagat tttagatgaa aagatctact      840



gccctcctga ggcttctgtg ctcctggctt cttacgccgt ccaggccaag tatggtgact      900



acgaccccag tgttcacaag cggggatttt tggcccaaga ggaattgctt ccaaaaaggg      960



taataaatct gtatcagatg actccggaaa tgtgggagga gagaattact gcttggtacg     1020



cagagcaccg aggccgagcc agggatgaag ctgaaatgga atatctgaag atagctcagg     1080



acctggagat gtacggtgtg aactactttg caatccggaa taaaaagggc acagagctgc     1140



tgcttggagt ggatgccctg gggcttcaca tttatgaccc tgagaacaga ctgaccccca     1200



agatctcctt cccgtggaat gaaatccgaa acatctcgta cagtgacaag gagtttacta     1260



ttaaaccact ggataagaaa attgatgtct tcaagtttaa ctcctcaaag cttcgtgtta     1320



ataagctgat tctccagcta tgtatcggga accatgatct atttatgagg agaaggaaag     1380



ccgattcttt ggaagttcag cagatgaaag cccaggccag ggaggagaag gctagaaagc     1440



agatggagcg gcagcgcctc gctcgagaga agcagatgag ggaggaggct gaacgcacga     1500



gggatgagtt ggagaggagg ctgctgcaga tgaaagaaga agcaacaatg gccaacgaag     1560



cactgatgcg gtctgaggag acagctgacc tgttggctga aaaggcccag atcaccgagg     1620



aggaggcaaa acttctggcc cagaaggccg cagaggctga gcaggaaatg cagcgcatca     1680



aggccacagc gattcgcacg gaggaggaga agcgcctgat ggagcagaag gtgctggaag     1740



ccgaggtgct ggcactgaag atggctgagg agtcagagag gagggccaaa gaggcagatc     1800



agctgaagca ggacctgcag gaagcacgcg aggcggagcg aagagccaag cagaagctcc     1860



tggagattgc caccaagccc acgtacccgc ccatgaaccc aattccagca ccgttgcctc     1920



ctgacatacc aagcttcaac ctcattggtg acagcctgtc tttcgacttc aaagatactg     1980



acatgaagcg gctttccatg gagatagaga aagaaaaagt ggaatacatg gaaaagagca     2040



agcatctgca ggagcagctc aatgaactca agacagaaat cgaggccttg aaactgaaag     2100



agagggagac agctctggat attctgcaca atgagaactc cgacaggggt ggcagcagca     2160



agcacaatac cattaaaaag cctcaagccc aaggcagaag acctatctgc atttgagccc     2220



tcaaactcac cttgcagagc gccaagtccc gagtggcctt ctttgaagag ctctagcagg     2280



tgacccagcc accccaggac ctgccacttc tcctgctacc gggaccgcgg gatggaccag     2340



atatcaagag agccatccat agggagctgg ctgggggttt ccgtgggagc tccagaactt     2400



tccccagctg agtgaagagc ccagcccctc ttatgtgcaa ttgccttgaa ctacgaccct     2460



gtagagattt ctctcatggc gttctagttc tctgacctga gtctttgttt taagaagtat     2520



ttgtcttcct ttgtctaatg tgggattcct gactcccttc gtccaaggca ccggtgtgtg     2580



tgtgtcttgc actccagagc tgacctccac cgcccagcct gggaagtcat tgtagggagt     2640



gagacactga agccctgaga agccagtgcc atcatcccca ccccgcccag ggttccggaa     2700



cattcattcc cccaccggtg aggacctggc atgcagcgaa gcagcccagc ccggcggatc     2760



ccaggccagc acgcctgccg gcttctcatc gtcagggagc ccgcccagag ctcgtgacga     2820



gcaagtgctg ggtccccgcc aggcaccccg aggcggcgct ctggctggca gctggtgggg     2880



aataggcagg gcagctgtgg ctggggagag actttaggca gaagctgtga tgcaggctga     2940



ctgccagccg aggggctggg tagtgccgtg cgggagctga tggtacaggg cactcgctgt     3000



ccccctccgg ccaccctaga ccagggtccg agaggcaggc aggagccact catgtcttcc     3060



ccattgcccg acgcccatag acgctccttc ctgtgtgggg ctggggtact ccctggtcgt     3120



actgcagtca gcacccgtaa cccggctatg accagggatc tgtaagccct gtggctccac     3180



aggtgctgct tctcactggc ccagactctg agctccaccg gcccagtctg cacggcccat     3240



ctgcttcacc ttccctccca gccacgtgcc agtggccaca gcccacttcc caacccactg     3300



ttgtacccag gcctcacttt gctgttgccc ttgtccctct tcgggccctg aattttctgt     3360



tccctggggg ccagccaggg ccctttgtgc ccctcccagc acaggcctga tgcaggtgtc     3420



cactcacagg tggcgctcac ctaggctgtc acaggaccca cctccatgcc aggcaacaga     3480



gggccacaga accaccccca cggctcactc cttggtctgg ggccaccttc ttgccctttc     3540



tttttttttt tttttttttt tttccgagat ggagtctctc tctgtcaccc aggtgggagt     3600



gtggtggcac aatctcggct cactgcaacc tccacctcct gagttcaagc aattctcctg     3660



cctcagcctc ccaagtagct gggactacag gcatgcacca ccacacttgg ccaatgttct     3720



gtatttttaa tagggacggg gttttgccat gttagctagg ctggtctcaa actcacacct     3780



gggattacag gcatgagcca ctgcacccag ccccttcttg ccctttcttt tctccatggc     3840



tgatgctgct gtggccagcc agggcccttg agatccttcc agtttggctg ttatgcaaag     3900



caggtgattt gtcttaatca gataaaagat agaggctatg ggggcctcaa gatttttgga     3960



gagcagaggt ggtctctggc aattccatct ggttttgaga aacttagcag ctcacagagc     4020



acagagatcc tgccttcttc ctactatcag gctgacctaa tggggttggg ctgctcggca     4080



actgcttggg tcaccttgcc ccaaggaaac cagccctggg tgccacccag ccacttaggg     4140



tctacagggt gggactccag acctagagcg taagtatgga tgttgtggcc ctgtgtcttc     4200



ctagtgtgac ccagccagga gcggaagctt caggcgtttg taaagtgagg tctggctctg     4260



cctcctccgt tttttttttt tttctgtttc tgtttctgtt ttttttttga gatggagtct     4320



cgctctgtcg cccaggctgg agtgcagtgt cacgatctca gctcactgca acctccgcct     4380



cccaggtaca agagattctc ctgcctcagc ctcccgagta gctgggacta caggcgtgtg     4440



ccaccatgcc tggctaattt ttgtattttt agtagagatg gggtttcgcc atgttagcca     4500



gactggtctc gaactcctga cctcaggtga tcctcccacc ccggcttccc aaagttctgg     4560



gattataggc gtgagccacc atgcccggtc tcttctcagt cttgaagccc atccctggat     4620



ttccaccagg agttactttc ctcctgacct gtaaatttgt tctttaacaa tggctgcagg     4680



tgggagcata tggtggttta taaaaacgct gtcgggcttt gtttccttct ttagctgccg     4740



tgtctacttc tgaagtctgg gaagtgccaa gccacgcggc ctcaagggag ctggctggtg     4800



tttgagctgt ggcagaagca cctggggctc cagggagcag gctgggaact gcaggacctt     4860



gctcagccag gagcacttcc ccctccttga ggcaggaata ctgaggtgcc tccccacaga     4920



tggagaaggt ggagaggagg atgggcctca ggagcatctc aagccccagt agcaggagaa     4980



agaaagaaag agatgcctgg ttttcacaga ctggttcctg tggctgggat gactgcatcc     5040



tttttttttt ttttttgaga cggagttttt gcctttgtcg cccaggctgg agtgcaatgg     5100



cgtgatctcg gctcaccgca acctccgcct cccggattca agcaattctc ctgcctcagc     5160



ctcccgagta gctgggatta caggcacgca cctccacgtc cggctaattt tgtattttta     5220



gtggagacgg ggtttctcca tgtcggtcag gctggtctcg aactcccgac ctcaggtgat     5280



ctgcccacct cggcctccca aagtgctggg attacaggca tgagccaccg cgcttggcca     5340



gactgcgtcc tttttaagcg aacattttag ggcctgggag tttgtcaagt aaggaagtct     5400



caagcccaaa gagcagcgtc ctgaccatgg tggtttcatt acgagccctt ctgctggctc     5460



tcaggcagaa gccccacagc accgggacca ttcatgaggt cactgcccag ctcatgatgt     5520



ccgtgaggct gtccttttgg ccagtagccg tgtgcagctg tgtggcacag atggcttcgt     5580



tcatcctgat caaggcccca cctcagccac agcagtcccc ccaacctgtg ttgtccaccc     5640



tattattcat gtacctgcca ggccctgcta gatagcaccc cgtggcatta cataacactt     5700



catgagtggc tgtgtcttgt aattttgggg acaggtttct ctctttccct ctcttttttt     5760



tgtcaaaagc ccagagactg acaaccagct gcagtgtcta agtgttcctc actgacaggg     5820



tggggcctca ccacccctgg agggagcagc gttggcaggg agacagcctg gcccagtgac     5880



cctgggccca agccagcccc tccagggctt tcagggaagc gccatccatt ttcaaagatg     5940



tcaaacgtca cttcttcctg tagggcccga gtcctgcctc ctatcagggc cagatcatag     6000



aaggctattt tctattctgg ggaacgatta taacttaaat gattgtttta ataaaaattc     6060



taagctggaa aataaaaaaa aaaaaaaaaa a                                    6091





<210>  163

<211>  590

<212>  PRT

<213>  Homo sapiens



<400>  163



Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 

1               5                   10                  15      





Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 

            20                  25                  30          





Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp 

        35                  40                  45              





Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu 

    50                  55                  60                  





Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys 

65                  70                  75                  80  





Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe 

                85                  90                  95      





Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu 

            100                 105                 110         





Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp 

        115                 120                 125             





Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr 

    130                 135                 140                 





Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg 

145                 150                 155                 160 





Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu 

                165                 170                 175     





Tyr Gln Met Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr 

            180                 185                 190         





Ala Glu His Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu 

        195                 200                 205             





Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile 

    210                 215                 220                 





Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly 

225                 230                 235                 240 





Leu His Ile Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe 

                245                 250                 255     





Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr 

            260                 265                 270         





Ile Lys Pro Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser 

        275                 280                 285             





Lys Leu Arg Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His 

    290                 295                 300                 





Asp Leu Phe Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln 

305                 310                 315                 320 





Met Lys Ala Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg 

                325                 330                 335     





Gln Arg Leu Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr 

            340                 345                 350         





Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr 

        355                 360                 365             





Met Ala Asn Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu 

    370                 375                 380                 





Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln 

385                 390                 395                 400 





Lys Ala Ala Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala 

                405                 410                 415     





Ile Arg Thr Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu 

            420                 425                 430         





Ala Glu Val Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala 

        435                 440                 445             





Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala 

    450                 455                 460                 





Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr 

465                 470                 475                 480 





Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro 

                485                 490                 495     





Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr 

            500                 505                 510         





Asp Met Lys Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr 

        515                 520                 525             





Met Glu Lys Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr 

    530                 535                 540                 





Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile 

545                 550                 555                 560 





Leu His Asn Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr 

                565                 570                 575     





Ile Lys Lys Pro Gln Ala Gln Gly Arg Arg Pro Ile Cys Ile 

            580                 585                 590 





<210>  164

<211>  3126

<212>  DNA

<213>  Homo sapiens



<400>  164

tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc cacgcgcgcg cgtacgcgcc       60



cgatgcagcg cggccccgtg accctagtcg gccgctgaga ggcgcgcgga gtctgggccg      120



ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc tccggcccga atcccggagt      180



gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc ctccctgcag ccgtcagggc      240



ccgtccccca actccccttt ccgctcaggc agggtcctcg cggcccatgc tggccgctgg      300



ggacccgcgc agcccagacc gttcccgggc cgggcagccg gccaccatgg tggccctgag      360



gcctgtgcag caactccagg ggggctaaag ggctcagagt gcaggccgtg gggcgcgagg      420



gtcccgggcc tgagccccgc gccatggccg gggccatcgc ttcccgcatg agcttcagct      480



ctctcaagag gaagcaaccc aagacgttca ccgtgaggat cgtcaccatg gacgccgaga      540



tggagttcaa ttgcgagatg aagtggaaag ggaaggacct ctttgatttg gtgtgccgga      600



ctctggggct ccgagaaacc tggttctttg gactgcagta cacaatcaag gacacagtgg      660



cctggctcaa aatggacaag aaggtactgg atcatgatgt ttcaaaggaa gaaccagtca      720



cctttcactt cttggccaaa ttttatcctg agaatgctga agaggagctg gttcaggaga      780



tcacacaaca tttattcttc ttacaggtaa agaagcagat tttagatgaa aagatctact      840



gccctcctga ggcttctgtg ctcctggctt cttacgccgt ccaggccaag tatggtgact      900



acgaccccag tgttcacaag cggggatttt tggcccaaga ggaattgctt ccaaaaaggg      960



taataaatct gtatcagatg actccggaaa tgtgggagga gagaattact gcttggtacg     1020



cagagcaccg aggccgagcc agggatgaag ctgaaatgga atatctgaag atagctcagg     1080



acctggagat gtacggtgtg aactactttg caatccggaa taaaaagggc acagagctgc     1140



tgcttggagt ggatgccctg gggcttcaca tttatgaccc tgagaacaga ctgaccccca     1200



agatctcctt cccgtggaat gaaatccgaa acatctcgta cagtgacaag gagtttacta     1260



ttaaaccact ggataagaaa attgatgtct tcaagtttaa ctcctcaaag cttcgtgtta     1320



ataagctgat tctccagcta tgtatcggga accatgatct atttatgagg agaaggaaag     1380



ccgattcttt ggaagttcag cagatgaaag cccaggccag ggaggagaag gctagaaagc     1440



agatggagcg gcagcgcctc gctcgagaga agcagatgag ggaggaggct gaacgcacga     1500



gggatgagtt ggagaggagg ctgctgcaga tgaaagaaga agcaacaatg gccaacgaag     1560



cactgatgcg gtctgaggag acagctgacc tgttggctga aaaggcccag atcaccgagg     1620



aggaggcaaa acttctggcc cagaaggccg cagaggctga gcaggaaatg cagcgcatca     1680



aggccacagc gattcgcacg gaggaggaga agcgcctgat ggagcagaag gtgctggaag     1740



ccgaggtgct ggcactgaag atggctgagg agtcagagag gagggccaaa gaggcagatc     1800



agctgaagca ggacctgcag gaagcacgcg aggcggagcg aagagccaag cagaagctcc     1860



tggagattgc caccaagccc acgtacccgc ccatgaaccc aattccagca ccgttgcctc     1920



ctgacatacc aagcttcaac ctcattggtg acagcctgtc tttcgacttc aaagatactg     1980



acatgaagcg gctttccatg gagatagaga aagaaaaagt ggaatacatg gaaaagagca     2040



agcatctgca ggagcagctc aatgaactca agacagaaat cgaggccttg aaactgaaag     2100



agagggagac agctctggat attctgcaca atgagaactc cgacaggggt ggcagcagca     2160



agcacaatac cattaaaaag cctcaagccc aaggcagaag acctatctgc atttgagccc     2220



tcaaagtagg ttgttcccag gtactctcta tgtggtgatg gtgctgccct ctgtgatact     2280



aacccgtgca tgagcttgcc tgtctctgtc ctcgggccac actgagccct tacgagggca     2340



ggtggtgcct gggtactggc cgcagcatgc tttgagtcta aaagtaggca cccaccctgt     2400



gaagccagac cagcctccag ggccccagaa gactgcctcg ttccgaagag catgtcatgg     2460



ggctgtagga ccagccattc ttcccatctc gggtcattgt tgggctgggg aaggttatgg     2520



cttcttgtcc agtcaggtgt gtctaaaagt cctttgtctt ggtggcatac tcctagcatg     2580



gaaatggggt caatctgggc actttggaga ctggtgtgtt taactcaaga tcaagacctt     2640



ttatgcgttg acagcctctc aagacccatg gtcacacctg gcagcttctg gtagtggggc     2700



aaaagggttg cttgtgctgg ctcattttcc tttagagctt tccctttctg cacacatccc     2760



ttttcttttc aaataaagca aacccagagc acagggtctg atatgtgagt ccacggggag     2820



tggactgtct gttcatctgt gctcagccac ctctgcttca gcttcctctc cataggctga     2880



gcagagatgt ggtcagagtg aactcacatt ggaacagtac actcacggca ccctggagag     2940



gagcggtcac tggttgctga gtgaattaac cgaatgtttg ctgcttttct cctgcaacag     3000



ttcattattc ctccagcatg cctaggcagt ggagagaatg tattttgccc aataataaaa     3060



tgacatcctg cctctaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3120



aaaaaa                                                                3126





<210>  165

<211>  590

<212>  PRT

<213>  Homo sapiens



<400>  165



Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 

1               5                   10                  15      





Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 

            20                  25                  30          





Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp 

        35                  40                  45              





Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu 

    50                  55                  60                  





Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys 

65                  70                  75                  80  





Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe 

                85                  90                  95      





Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu 

            100                 105                 110         





Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp 

        115                 120                 125             





Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr 

    130                 135                 140                 





Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg 

145                 150                 155                 160 





Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu 

                165                 170                 175     





Tyr Gln Met Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr 

            180                 185                 190         





Ala Glu His Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu 

        195                 200                 205             





Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile 

    210                 215                 220                 





Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly 

225                 230                 235                 240 





Leu His Ile Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe 

                245                 250                 255     





Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr 

            260                 265                 270         





Ile Lys Pro Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser 

        275                 280                 285             





Lys Leu Arg Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His 

    290                 295                 300                 





Asp Leu Phe Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln 

305                 310                 315                 320 





Met Lys Ala Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg 

                325                 330                 335     





Gln Arg Leu Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr 

            340                 345                 350         





Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr 

        355                 360                 365             





Met Ala Asn Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu 

    370                 375                 380                 





Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln 

385                 390                 395                 400 





Lys Ala Ala Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala 

                405                 410                 415     





Ile Arg Thr Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu 

            420                 425                 430         





Ala Glu Val Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala 

        435                 440                 445             





Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala 

    450                 455                 460                 





Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr 

465                 470                 475                 480 





Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro 

                485                 490                 495     





Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr 

            500                 505                 510         





Asp Met Lys Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr 

        515                 520                 525             





Met Glu Lys Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr 

    530                 535                 540                 





Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile 

545                 550                 555                 560 





Leu His Asn Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr 

                565                 570                 575     





Ile Lys Lys Pro Gln Ala Gln Gly Arg Arg Pro Ile Cys Ile 

            580                 585                 590 





<210>  166

<211>  5965

<212>  DNA

<213>  Homo sapiens



<400>  166

tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc cacgcgcgcg cgtacgcgcc       60



cgatgcagcg cggccccgtg accctagtcg gccgctgaga ggcgcgcgga gtctgggccg      120



ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc tccggcccga atcccggagt      180



gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc ctccctgcag ccgtcagggc      240



ccgtccccca actccccttt ccgctcaggc agggtcctcg cggcccatgc tggccgctgg      300



ggacccgcgc agcccagacc gttcccgggc cgggcagccg gccaccatgg tggccctgag      360



gcctgtgcag caactccagg ggggctaaag ggctcagagt gcaggccgtg gggcgcgagg      420



gtcccgggcc tgagccccgc gccatggccg gggccatcgc ttcccgcatg agcttcagct      480



ctctcaagag gaagcaaccc aagacgttca ccgtgaggat cgtcaccatg gacgccgaga      540



tggagttcaa ttgcgaggta ctggatcatg atgtttcaaa ggaagaacca gtcacctttc      600



acttcttggc caaattttat cctgagaatg ctgaagagga gctggttcag gagatcacac      660



aacatttatt cttcttacag gtaaagaagc agattttaga tgaaaagatc tactgccctc      720



ctgaggcttc tgtgctcctg gcttcttacg ccgtccaggc caagtatggt gactacgacc      780



ccagtgttca caagcgggga tttttggccc aagaggaatt gcttccaaaa agggtaataa      840



atctgtatca gatgactccg gaaatgtggg aggagagaat tactgcttgg tacgcagagc      900



accgaggccg agccagggat gaagctgaaa tggaatatct gaagatagct caggacctgg      960



agatgtacgg tgtgaactac tttgcaatcc ggaataaaaa gggcacagag ctgctgcttg     1020



gagtggatgc cctggggctt cacatttatg accctgagaa cagactgacc cccaagatct     1080



ccttcccgtg gaatgaaatc cgaaacatct cgtacagtga caaggagttt actattaaac     1140



cactggataa gaaaattgat gtcttcaagt ttaactcctc aaagcttcgt gttaataagc     1200



tgattctcca gctatgtatc gggaaccatg atctatttat gaggagaagg aaagccgatt     1260



ctttggaagt tcagcagatg aaagcccagg ccagggagga gaaggctaga aagcagatgg     1320



agcggcagcg cctcgctcga gagaagcaga tgagggagga ggctgaacgc acgagggatg     1380



agttggagag gaggctgctg cagatgaaag aagaagcaac aatggccaac gaagcactga     1440



tgcggtctga ggagacagct gacctgttgg ctgaaaaggc ccagatcacc gaggaggagg     1500



caaaacttct ggcccagaag gccgcagagg ctgagcagga aatgcagcgc atcaaggcca     1560



cagcgattcg cacggaggag gagaagcgcc tgatggagca gaaggtgctg gaagccgagg     1620



tgctggcact gaagatggct gaggagtcag agaggagggc caaagaggca gatcagctga     1680



agcaggacct gcaggaagca cgcgaggcgg agcgaagagc caagcagaag ctcctggaga     1740



ttgccaccaa gcccacgtac ccgcccatga acccaattcc agcaccgttg cctcctgaca     1800



taccaagctt caacctcatt ggtgacagcc tgtctttcga cttcaaagat actgacatga     1860



agcggctttc catggagata gagaaagaaa aagtggaata catggaaaag agcaagcatc     1920



tgcaggagca gctcaatgaa ctcaagacag aaatcgaggc cttgaaactg aaagagaggg     1980



agacagctct ggatattctg cacaatgaga actccgacag gggtggcagc agcaagcaca     2040



ataccattaa aaagcctcaa gcccaaggca gaagacctat ctgcatttga gccctcaaac     2100



tcaccttgca gagcgccaag tcccgagtgg ccttctttga agagctctag caggtgaccc     2160



agccacccca ggacctgcca cttctcctgc taccgggacc gcgggatgga ccagatatca     2220



agagagccat ccatagggag ctggctgggg gtttccgtgg gagctccaga actttcccca     2280



gctgagtgaa gagcccagcc cctcttatgt gcaattgcct tgaactacga ccctgtagag     2340



atttctctca tggcgttcta gttctctgac ctgagtcttt gttttaagaa gtatttgtct     2400



tcctttgtct aatgtgggat tcctgactcc cttcgtccaa ggcaccggtg tgtgtgtgtc     2460



ttgcactcca gagctgacct ccaccgccca gcctgggaag tcattgtagg gagtgagaca     2520



ctgaagccct gagaagccag tgccatcatc cccaccccgc ccagggttcc ggaacattca     2580



ttcccccacc ggtgaggacc tggcatgcag cgaagcagcc cagcccggcg gatcccaggc     2640



cagcacgcct gccggcttct catcgtcagg gagcccgccc agagctcgtg acgagcaagt     2700



gctgggtccc cgccaggcac cccgaggcgg cgctctggct ggcagctggt ggggaatagg     2760



cagggcagct gtggctgggg agagacttta ggcagaagct gtgatgcagg ctgactgcca     2820



gccgaggggc tgggtagtgc cgtgcgggag ctgatggtac agggcactcg ctgtccccct     2880



ccggccaccc tagaccaggg tccgagaggc aggcaggagc cactcatgtc ttccccattg     2940



cccgacgccc atagacgctc cttcctgtgt ggggctgggg tactccctgg tcgtactgca     3000



gtcagcaccc gtaacccggc tatgaccagg gatctgtaag ccctgtggct ccacaggtgc     3060



tgcttctcac tggcccagac tctgagctcc accggcccag tctgcacggc ccatctgctt     3120



caccttccct cccagccacg tgccagtggc cacagcccac ttcccaaccc actgttgtac     3180



ccaggcctca ctttgctgtt gcccttgtcc ctcttcgggc cctgaatttt ctgttccctg     3240



ggggccagcc agggcccttt gtgcccctcc cagcacaggc ctgatgcagg tgtccactca     3300



caggtggcgc tcacctaggc tgtcacagga cccacctcca tgccaggcaa cagagggcca     3360



cagaaccacc cccacggctc actccttggt ctggggccac cttcttgccc tttctttttt     3420



tttttttttt tttttttccg agatggagtc tctctctgtc acccaggtgg gagtgtggtg     3480



gcacaatctc ggctcactgc aacctccacc tcctgagttc aagcaattct cctgcctcag     3540



cctcccaagt agctgggact acaggcatgc accaccacac ttggccaatg ttctgtattt     3600



ttaataggga cggggttttg ccatgttagc taggctggtc tcaaactcac acctgggatt     3660



acaggcatga gccactgcac ccagcccctt cttgcccttt cttttctcca tggctgatgc     3720



tgctgtggcc agccagggcc cttgagatcc ttccagtttg gctgttatgc aaagcaggtg     3780



atttgtctta atcagataaa agatagaggc tatgggggcc tcaagatttt tggagagcag     3840



aggtggtctc tggcaattcc atctggtttt gagaaactta gcagctcaca gagcacagag     3900



atcctgcctt cttcctacta tcaggctgac ctaatggggt tgggctgctc ggcaactgct     3960



tgggtcacct tgccccaagg aaaccagccc tgggtgccac ccagccactt agggtctaca     4020



gggtgggact ccagacctag agcgtaagta tggatgttgt ggccctgtgt cttcctagtg     4080



tgacccagcc aggagcggaa gcttcaggcg tttgtaaagt gaggtctggc tctgcctcct     4140



ccgttttttt tttttttctg tttctgtttc tgtttttttt ttgagatgga gtctcgctct     4200



gtcgcccagg ctggagtgca gtgtcacgat ctcagctcac tgcaacctcc gcctcccagg     4260



tacaagagat tctcctgcct cagcctcccg agtagctggg actacaggcg tgtgccacca     4320



tgcctggcta atttttgtat ttttagtaga gatggggttt cgccatgtta gccagactgg     4380



tctcgaactc ctgacctcag gtgatcctcc caccccggct tcccaaagtt ctgggattat     4440



aggcgtgagc caccatgccc ggtctcttct cagtcttgaa gcccatccct ggatttccac     4500



caggagttac tttcctcctg acctgtaaat ttgttcttta acaatggctg caggtgggag     4560



catatggtgg tttataaaaa cgctgtcggg ctttgtttcc ttctttagct gccgtgtcta     4620



cttctgaagt ctgggaagtg ccaagccacg cggcctcaag ggagctggct ggtgtttgag     4680



ctgtggcaga agcacctggg gctccaggga gcaggctggg aactgcagga ccttgctcag     4740



ccaggagcac ttccccctcc ttgaggcagg aatactgagg tgcctcccca cagatggaga     4800



aggtggagag gaggatgggc ctcaggagca tctcaagccc cagtagcagg agaaagaaag     4860



aaagagatgc ctggttttca cagactggtt cctgtggctg ggatgactgc atcctttttt     4920



tttttttttt gagacggagt ttttgccttt gtcgcccagg ctggagtgca atggcgtgat     4980



ctcggctcac cgcaacctcc gcctcccgga ttcaagcaat tctcctgcct cagcctcccg     5040



agtagctggg attacaggca cgcacctcca cgtccggcta attttgtatt tttagtggag     5100



acggggtttc tccatgtcgg tcaggctggt ctcgaactcc cgacctcagg tgatctgccc     5160



acctcggcct cccaaagtgc tgggattaca ggcatgagcc accgcgcttg gccagactgc     5220



gtccttttta agcgaacatt ttagggcctg ggagtttgtc aagtaaggaa gtctcaagcc     5280



caaagagcag cgtcctgacc atggtggttt cattacgagc ccttctgctg gctctcaggc     5340



agaagcccca cagcaccggg accattcatg aggtcactgc ccagctcatg atgtccgtga     5400



ggctgtcctt ttggccagta gccgtgtgca gctgtgtggc acagatggct tcgttcatcc     5460



tgatcaaggc cccacctcag ccacagcagt ccccccaacc tgtgttgtcc accctattat     5520



tcatgtacct gccaggccct gctagatagc accccgtggc attacataac acttcatgag     5580



tggctgtgtc ttgtaatttt ggggacaggt ttctctcttt ccctctcttt tttttgtcaa     5640



aagcccagag actgacaacc agctgcagtg tctaagtgtt cctcactgac agggtggggc     5700



ctcaccaccc ctggagggag cagcgttggc agggagacag cctggcccag tgaccctggg     5760



cccaagccag cccctccagg gctttcaggg aagcgccatc cattttcaaa gatgtcaaac     5820



gtcacttctt cctgtagggc ccgagtcctg cctcctatca gggccagatc atagaaggct     5880



attttctatt ctggggaacg attataactt aaatgattgt tttaataaaa attctaagct     5940



ggaaaataaa aaaaaaaaaa aaaaa                                           5965





<210>  167

<211>  548

<212>  PRT

<213>  Homo sapiens



<400>  167



Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 

1               5                   10                  15      





Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 

            20                  25                  30          





Met Glu Phe Asn Cys Glu Val Leu Asp His Asp Val Ser Lys Glu Glu 

        35                  40                  45              





Pro Val Thr Phe His Phe Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu 

    50                  55                  60                  





Glu Glu Leu Val Gln Glu Ile Thr Gln His Leu Phe Phe Leu Gln Val 

65                  70                  75                  80  





Lys Lys Gln Ile Leu Asp Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser 

                85                  90                  95      





Val Leu Leu Ala Ser Tyr Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp 

            100                 105                 110         





Pro Ser Val His Lys Arg Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro 

        115                 120                 125             





Lys Arg Val Ile Asn Leu Tyr Gln Met Thr Pro Glu Met Trp Glu Glu 

    130                 135                 140                 





Arg Ile Thr Ala Trp Tyr Ala Glu His Arg Gly Arg Ala Arg Asp Glu 

145                 150                 155                 160 





Ala Glu Met Glu Tyr Leu Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly 

                165                 170                 175     





Val Asn Tyr Phe Ala Ile Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu 

            180                 185                 190         





Gly Val Asp Ala Leu Gly Leu His Ile Tyr Asp Pro Glu Asn Arg Leu 

        195                 200                 205             





Thr Pro Lys Ile Ser Phe Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr 

    210                 215                 220                 





Ser Asp Lys Glu Phe Thr Ile Lys Pro Leu Asp Lys Lys Ile Asp Val 

225                 230                 235                 240 





Phe Lys Phe Asn Ser Ser Lys Leu Arg Val Asn Lys Leu Ile Leu Gln 

                245                 250                 255     





Leu Cys Ile Gly Asn His Asp Leu Phe Met Arg Arg Arg Lys Ala Asp 

            260                 265                 270         





Ser Leu Glu Val Gln Gln Met Lys Ala Gln Ala Arg Glu Glu Lys Ala 

        275                 280                 285             





Arg Lys Gln Met Glu Arg Gln Arg Leu Ala Arg Glu Lys Gln Met Arg 

    290                 295                 300                 





Glu Glu Ala Glu Arg Thr Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln 

305                 310                 315                 320 





Met Lys Glu Glu Ala Thr Met Ala Asn Glu Ala Leu Met Arg Ser Glu 

                325                 330                 335     





Glu Thr Ala Asp Leu Leu Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu 

            340                 345                 350         





Ala Lys Leu Leu Ala Gln Lys Ala Ala Glu Ala Glu Gln Glu Met Gln 

        355                 360                 365             





Arg Ile Lys Ala Thr Ala Ile Arg Thr Glu Glu Glu Lys Arg Leu Met 

    370                 375                 380                 





Glu Gln Lys Val Leu Glu Ala Glu Val Leu Ala Leu Lys Met Ala Glu 

385                 390                 395                 400 





Glu Ser Glu Arg Arg Ala Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu 

                405                 410                 415     





Gln Glu Ala Arg Glu Ala Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu 

            420                 425                 430         





Ile Ala Thr Lys Pro Thr Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro 

        435                 440                 445             





Leu Pro Pro Asp Ile Pro Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser 

    450                 455                 460                 





Phe Asp Phe Lys Asp Thr Asp Met Lys Arg Leu Ser Met Glu Ile Glu 

465                 470                 475                 480 





Lys Glu Lys Val Glu Tyr Met Glu Lys Ser Lys His Leu Gln Glu Gln 

                485                 490                 495     





Leu Asn Glu Leu Lys Thr Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg 

            500                 505                 510         





Glu Thr Ala Leu Asp Ile Leu His Asn Glu Asn Ser Asp Arg Gly Gly 

        515                 520                 525             





Ser Ser Lys His Asn Thr Ile Lys Lys Pro Gln Ala Gln Gly Arg Arg 

    530                 535                 540                 





Pro Ile Cys Ile 

545             





<210>  168

<211>  5968

<212>  DNA

<213>  Homo sapiens



<400>  168

tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc cacgcgcgcg cgtacgcgcc       60



cgatgcagcg cggccccgtg accctagtcg gccgctgaga ggcgcgcgga gtctgggccg      120



ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc tccggcccga atcccggagt      180



gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc ctccctgcag ccgtcagggc      240



ccgtccccca actccccttt ccgctcaggc agggtcctcg cggcccatgc tggccgctgg      300



ggacccgcgc agcccagacc gttcccgggc cgggcagccg gccaccatgg tggccctgag      360



gcctgtgcag caactccagg ggggctaaag ggctcagagt gcaggccgtg gggcgcgagg      420



gtcccgggcc tgagccccgc gccatggccg gggccatcgc ttcccgcatg agcttcagct      480



ctctcaagag gaagcaaccc aagacgttca ccgtgaggat cgtcaccatg gacgccgaga      540



tggagttcaa ttgcgagatg aagtggaaag ggaaggacct ctttgatttg gtgtgccgga      600



ctctggggct ccgagaaacc tggttctttg gactgcagta cacaatcaag gacacagtgg      660



cctggctcaa aatggacaag aaggtaaaga agcagatttt agatgaaaag atctactgcc      720



ctcctgaggc ttctgtgctc ctggcttctt acgccgtcca ggccaagtat ggtgactacg      780



accccagtgt tcacaagcgg ggatttttgg cccaagagga attgcttcca aaaagggtaa      840



taaatctgta tcagatgact ccggaaatgt gggaggagag aattactgct tggtacgcag      900



agcaccgagg ccgagccagg gatgaagctg aaatggaata tctgaagata gctcaggacc      960



tggagatgta cggtgtgaac tactttgcaa tccggaataa aaagggcaca gagctgctgc     1020



ttggagtgga tgccctgggg cttcacattt atgaccctga gaacagactg acccccaaga     1080



tctccttccc gtggaatgaa atccgaaaca tctcgtacag tgacaaggag tttactatta     1140



aaccactgga taagaaaatt gatgtcttca agtttaactc ctcaaagctt cgtgttaata     1200



agctgattct ccagctatgt atcgggaacc atgatctatt tatgaggaga aggaaagccg     1260



attctttgga agttcagcag atgaaagccc aggccaggga ggagaaggct agaaagcaga     1320



tggagcggca gcgcctcgct cgagagaagc agatgaggga ggaggctgaa cgcacgaggg     1380



atgagttgga gaggaggctg ctgcagatga aagaagaagc aacaatggcc aacgaagcac     1440



tgatgcggtc tgaggagaca gctgacctgt tggctgaaaa ggcccagatc accgaggagg     1500



aggcaaaact tctggcccag aaggccgcag aggctgagca ggaaatgcag cgcatcaagg     1560



ccacagcgat tcgcacggag gaggagaagc gcctgatgga gcagaaggtg ctggaagccg     1620



aggtgctggc actgaagatg gctgaggagt cagagaggag ggccaaagag gcagatcagc     1680



tgaagcagga cctgcaggaa gcacgcgagg cggagcgaag agccaagcag aagctcctgg     1740



agattgccac caagcccacg tacccgccca tgaacccaat tccagcaccg ttgcctcctg     1800



acataccaag cttcaacctc attggtgaca gcctgtcttt cgacttcaaa gatactgaca     1860



tgaagcggct ttccatggag atagagaaag aaaaagtgga atacatggaa aagagcaagc     1920



atctgcagga gcagctcaat gaactcaaga cagaaatcga ggccttgaaa ctgaaagaga     1980



gggagacagc tctggatatt ctgcacaatg agaactccga caggggtggc agcagcaagc     2040



acaataccat taaaaagcct caagcccaag gcagaagacc tatctgcatt tgagccctca     2100



aactcacctt gcagagcgcc aagtcccgag tggccttctt tgaagagctc tagcaggtga     2160



cccagccacc ccaggacctg ccacttctcc tgctaccggg accgcgggat ggaccagata     2220



tcaagagagc catccatagg gagctggctg ggggtttccg tgggagctcc agaactttcc     2280



ccagctgagt gaagagccca gcccctctta tgtgcaattg ccttgaacta cgaccctgta     2340



gagatttctc tcatggcgtt ctagttctct gacctgagtc tttgttttaa gaagtatttg     2400



tcttcctttg tctaatgtgg gattcctgac tcccttcgtc caaggcaccg gtgtgtgtgt     2460



gtcttgcact ccagagctga cctccaccgc ccagcctggg aagtcattgt agggagtgag     2520



acactgaagc cctgagaagc cagtgccatc atccccaccc cgcccagggt tccggaacat     2580



tcattccccc accggtgagg acctggcatg cagcgaagca gcccagcccg gcggatccca     2640



ggccagcacg cctgccggct tctcatcgtc agggagcccg cccagagctc gtgacgagca     2700



agtgctgggt ccccgccagg caccccgagg cggcgctctg gctggcagct ggtggggaat     2760



aggcagggca gctgtggctg gggagagact ttaggcagaa gctgtgatgc aggctgactg     2820



ccagccgagg ggctgggtag tgccgtgcgg gagctgatgg tacagggcac tcgctgtccc     2880



cctccggcca ccctagacca gggtccgaga ggcaggcagg agccactcat gtcttcccca     2940



ttgcccgacg cccatagacg ctccttcctg tgtggggctg gggtactccc tggtcgtact     3000



gcagtcagca cccgtaaccc ggctatgacc agggatctgt aagccctgtg gctccacagg     3060



tgctgcttct cactggccca gactctgagc tccaccggcc cagtctgcac ggcccatctg     3120



cttcaccttc cctcccagcc acgtgccagt ggccacagcc cacttcccaa cccactgttg     3180



tacccaggcc tcactttgct gttgcccttg tccctcttcg ggccctgaat tttctgttcc     3240



ctgggggcca gccagggccc tttgtgcccc tcccagcaca ggcctgatgc aggtgtccac     3300



tcacaggtgg cgctcaccta ggctgtcaca ggacccacct ccatgccagg caacagaggg     3360



ccacagaacc acccccacgg ctcactcctt ggtctggggc caccttcttg ccctttcttt     3420



tttttttttt tttttttttt ccgagatgga gtctctctct gtcacccagg tgggagtgtg     3480



gtggcacaat ctcggctcac tgcaacctcc acctcctgag ttcaagcaat tctcctgcct     3540



cagcctccca agtagctggg actacaggca tgcaccacca cacttggcca atgttctgta     3600



tttttaatag ggacggggtt ttgccatgtt agctaggctg gtctcaaact cacacctggg     3660



attacaggca tgagccactg cacccagccc cttcttgccc tttcttttct ccatggctga     3720



tgctgctgtg gccagccagg gcccttgaga tccttccagt ttggctgtta tgcaaagcag     3780



gtgatttgtc ttaatcagat aaaagataga ggctatgggg gcctcaagat ttttggagag     3840



cagaggtggt ctctggcaat tccatctggt tttgagaaac ttagcagctc acagagcaca     3900



gagatcctgc cttcttccta ctatcaggct gacctaatgg ggttgggctg ctcggcaact     3960



gcttgggtca ccttgcccca aggaaaccag ccctgggtgc cacccagcca cttagggtct     4020



acagggtggg actccagacc tagagcgtaa gtatggatgt tgtggccctg tgtcttccta     4080



gtgtgaccca gccaggagcg gaagcttcag gcgtttgtaa agtgaggtct ggctctgcct     4140



cctccgtttt tttttttttt ctgtttctgt ttctgttttt tttttgagat ggagtctcgc     4200



tctgtcgccc aggctggagt gcagtgtcac gatctcagct cactgcaacc tccgcctccc     4260



aggtacaaga gattctcctg cctcagcctc ccgagtagct gggactacag gcgtgtgcca     4320



ccatgcctgg ctaatttttg tatttttagt agagatgggg tttcgccatg ttagccagac     4380



tggtctcgaa ctcctgacct caggtgatcc tcccaccccg gcttcccaaa gttctgggat     4440



tataggcgtg agccaccatg cccggtctct tctcagtctt gaagcccatc cctggatttc     4500



caccaggagt tactttcctc ctgacctgta aatttgttct ttaacaatgg ctgcaggtgg     4560



gagcatatgg tggtttataa aaacgctgtc gggctttgtt tccttcttta gctgccgtgt     4620



ctacttctga agtctgggaa gtgccaagcc acgcggcctc aagggagctg gctggtgttt     4680



gagctgtggc agaagcacct ggggctccag ggagcaggct gggaactgca ggaccttgct     4740



cagccaggag cacttccccc tccttgaggc aggaatactg aggtgcctcc ccacagatgg     4800



agaaggtgga gaggaggatg ggcctcagga gcatctcaag ccccagtagc aggagaaaga     4860



aagaaagaga tgcctggttt tcacagactg gttcctgtgg ctgggatgac tgcatccttt     4920



tttttttttt tttgagacgg agtttttgcc tttgtcgccc aggctggagt gcaatggcgt     4980



gatctcggct caccgcaacc tccgcctccc ggattcaagc aattctcctg cctcagcctc     5040



ccgagtagct gggattacag gcacgcacct ccacgtccgg ctaattttgt atttttagtg     5100



gagacggggt ttctccatgt cggtcaggct ggtctcgaac tcccgacctc aggtgatctg     5160



cccacctcgg cctcccaaag tgctgggatt acaggcatga gccaccgcgc ttggccagac     5220



tgcgtccttt ttaagcgaac attttagggc ctgggagttt gtcaagtaag gaagtctcaa     5280



gcccaaagag cagcgtcctg accatggtgg tttcattacg agcccttctg ctggctctca     5340



ggcagaagcc ccacagcacc gggaccattc atgaggtcac tgcccagctc atgatgtccg     5400



tgaggctgtc cttttggcca gtagccgtgt gcagctgtgt ggcacagatg gcttcgttca     5460



tcctgatcaa ggccccacct cagccacagc agtcccccca acctgtgttg tccaccctat     5520



tattcatgta cctgccaggc cctgctagat agcaccccgt ggcattacat aacacttcat     5580



gagtggctgt gtcttgtaat tttggggaca ggtttctctc tttccctctc ttttttttgt     5640



caaaagccca gagactgaca accagctgca gtgtctaagt gttcctcact gacagggtgg     5700



ggcctcacca cccctggagg gagcagcgtt ggcagggaga cagcctggcc cagtgaccct     5760



gggcccaagc cagcccctcc agggctttca gggaagcgcc atccattttc aaagatgtca     5820



aacgtcactt cttcctgtag ggcccgagtc ctgcctccta tcagggccag atcatagaag     5880



gctattttct attctgggga acgattataa cttaaatgat tgttttaata aaaattctaa     5940



gctggaaaat aaaaaaaaaa aaaaaaaa                                        5968





<210>  169

<211>  549

<212>  PRT

<213>  Homo sapiens



<400>  169



Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 

1               5                   10                  15      





Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 

            20                  25                  30          





Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp 

        35                  40                  45              





Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu 

    50                  55                  60                  





Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys 

65                  70                  75                  80  





Val Lys Lys Gln Ile Leu Asp Glu Lys Ile Tyr Cys Pro Pro Glu Ala 

                85                  90                  95      





Ser Val Leu Leu Ala Ser Tyr Ala Val Gln Ala Lys Tyr Gly Asp Tyr 

            100                 105                 110         





Asp Pro Ser Val His Lys Arg Gly Phe Leu Ala Gln Glu Glu Leu Leu 

        115                 120                 125             





Pro Lys Arg Val Ile Asn Leu Tyr Gln Met Thr Pro Glu Met Trp Glu 

    130                 135                 140                 





Glu Arg Ile Thr Ala Trp Tyr Ala Glu His Arg Gly Arg Ala Arg Asp 

145                 150                 155                 160 





Glu Ala Glu Met Glu Tyr Leu Lys Ile Ala Gln Asp Leu Glu Met Tyr 

                165                 170                 175     





Gly Val Asn Tyr Phe Ala Ile Arg Asn Lys Lys Gly Thr Glu Leu Leu 

            180                 185                 190         





Leu Gly Val Asp Ala Leu Gly Leu His Ile Tyr Asp Pro Glu Asn Arg 

        195                 200                 205             





Leu Thr Pro Lys Ile Ser Phe Pro Trp Asn Glu Ile Arg Asn Ile Ser 

    210                 215                 220                 





Tyr Ser Asp Lys Glu Phe Thr Ile Lys Pro Leu Asp Lys Lys Ile Asp 

225                 230                 235                 240 





Val Phe Lys Phe Asn Ser Ser Lys Leu Arg Val Asn Lys Leu Ile Leu 

                245                 250                 255     





Gln Leu Cys Ile Gly Asn His Asp Leu Phe Met Arg Arg Arg Lys Ala 

            260                 265                 270         





Asp Ser Leu Glu Val Gln Gln Met Lys Ala Gln Ala Arg Glu Glu Lys 

        275                 280                 285             





Ala Arg Lys Gln Met Glu Arg Gln Arg Leu Ala Arg Glu Lys Gln Met 

    290                 295                 300                 





Arg Glu Glu Ala Glu Arg Thr Arg Asp Glu Leu Glu Arg Arg Leu Leu 

305                 310                 315                 320 





Gln Met Lys Glu Glu Ala Thr Met Ala Asn Glu Ala Leu Met Arg Ser 

                325                 330                 335     





Glu Glu Thr Ala Asp Leu Leu Ala Glu Lys Ala Gln Ile Thr Glu Glu 

            340                 345                 350         





Glu Ala Lys Leu Leu Ala Gln Lys Ala Ala Glu Ala Glu Gln Glu Met 

        355                 360                 365             





Gln Arg Ile Lys Ala Thr Ala Ile Arg Thr Glu Glu Glu Lys Arg Leu 

    370                 375                 380                 





Met Glu Gln Lys Val Leu Glu Ala Glu Val Leu Ala Leu Lys Met Ala 

385                 390                 395                 400 





Glu Glu Ser Glu Arg Arg Ala Lys Glu Ala Asp Gln Leu Lys Gln Asp 

                405                 410                 415     





Leu Gln Glu Ala Arg Glu Ala Glu Arg Arg Ala Lys Gln Lys Leu Leu 

            420                 425                 430         





Glu Ile Ala Thr Lys Pro Thr Tyr Pro Pro Met Asn Pro Ile Pro Ala 

        435                 440                 445             





Pro Leu Pro Pro Asp Ile Pro Ser Phe Asn Leu Ile Gly Asp Ser Leu 

    450                 455                 460                 





Ser Phe Asp Phe Lys Asp Thr Asp Met Lys Arg Leu Ser Met Glu Ile 

465                 470                 475                 480 





Glu Lys Glu Lys Val Glu Tyr Met Glu Lys Ser Lys His Leu Gln Glu 

                485                 490                 495     





Gln Leu Asn Glu Leu Lys Thr Glu Ile Glu Ala Leu Lys Leu Lys Glu 

            500                 505                 510         





Arg Glu Thr Ala Leu Asp Ile Leu His Asn Glu Asn Ser Asp Arg Gly 

        515                 520                 525             





Gly Ser Ser Lys His Asn Thr Ile Lys Lys Pro Gln Ala Gln Gly Arg 

    530                 535                 540                 





Arg Pro Ile Cys Ile 

545                 





<210>  170

<211>  5842

<212>  DNA

<213>  Homo sapiens



<400>  170

tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc cacgcgcgcg cgtacgcgcc       60



cgatgcagcg cggccccgtg accctagtcg gccgctgaga ggcgcgcgga gtctgggccg      120



ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc tccggcccga atcccggagt      180



gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc ctccctgcag ccgtcagggc      240



ccgtccccca actccccttt ccgctcaggc agggtcctcg cggcccatgc tggccgctgg      300



ggacccgcgc agcccagacc gttcccgggc cgggcagccg gccaccatgg tggccctgag      360



gcctgtgcag caactccagg ggggctaaag ggctcagagt gcaggccgtg gggcgcgagg      420



gtcccgggcc tgagccccgc gccatggccg gggccatcgc ttcccgcatg agcttcagct      480



ctctcaagag gaagcaaccc aagacgttca ccgtgaggat cgtcaccatg gacgccgaga      540



tggagttcaa ttgcgaggta aagaagcaga ttttagatga aaagatctac tgccctcctg      600



aggcttctgt gctcctggct tcttacgccg tccaggccaa gtatggtgac tacgacccca      660



gtgttcacaa gcggggattt ttggcccaag aggaattgct tccaaaaagg gtaataaatc      720



tgtatcagat gactccggaa atgtgggagg agagaattac tgcttggtac gcagagcacc      780



gaggccgagc cagggatgaa gctgaaatgg aatatctgaa gatagctcag gacctggaga      840



tgtacggtgt gaactacttt gcaatccgga ataaaaaggg cacagagctg ctgcttggag      900



tggatgccct ggggcttcac atttatgacc ctgagaacag actgaccccc aagatctcct      960



tcccgtggaa tgaaatccga aacatctcgt acagtgacaa ggagtttact attaaaccac     1020



tggataagaa aattgatgtc ttcaagttta actcctcaaa gcttcgtgtt aataagctga     1080



ttctccagct atgtatcggg aaccatgatc tatttatgag gagaaggaaa gccgattctt     1140



tggaagttca gcagatgaaa gcccaggcca gggaggagaa ggctagaaag cagatggagc     1200



ggcagcgcct cgctcgagag aagcagatga gggaggaggc tgaacgcacg agggatgagt     1260



tggagaggag gctgctgcag atgaaagaag aagcaacaat ggccaacgaa gcactgatgc     1320



ggtctgagga gacagctgac ctgttggctg aaaaggccca gatcaccgag gaggaggcaa     1380



aacttctggc ccagaaggcc gcagaggctg agcaggaaat gcagcgcatc aaggccacag     1440



cgattcgcac ggaggaggag aagcgcctga tggagcagaa ggtgctggaa gccgaggtgc     1500



tggcactgaa gatggctgag gagtcagaga ggagggccaa agaggcagat cagctgaagc     1560



aggacctgca ggaagcacgc gaggcggagc gaagagccaa gcagaagctc ctggagattg     1620



ccaccaagcc cacgtacccg cccatgaacc caattccagc accgttgcct cctgacatac     1680



caagcttcaa cctcattggt gacagcctgt ctttcgactt caaagatact gacatgaagc     1740



ggctttccat ggagatagag aaagaaaaag tggaatacat ggaaaagagc aagcatctgc     1800



aggagcagct caatgaactc aagacagaaa tcgaggcctt gaaactgaaa gagagggaga     1860



cagctctgga tattctgcac aatgagaact ccgacagggg tggcagcagc aagcacaata     1920



ccattaaaaa gcctcaagcc caaggcagaa gacctatctg catttgagcc ctcaaactca     1980



ccttgcagag cgccaagtcc cgagtggcct tctttgaaga gctctagcag gtgacccagc     2040



caccccagga cctgccactt ctcctgctac cgggaccgcg ggatggacca gatatcaaga     2100



gagccatcca tagggagctg gctgggggtt tccgtgggag ctccagaact ttccccagct     2160



gagtgaagag cccagcccct cttatgtgca attgccttga actacgaccc tgtagagatt     2220



tctctcatgg cgttctagtt ctctgacctg agtctttgtt ttaagaagta tttgtcttcc     2280



tttgtctaat gtgggattcc tgactccctt cgtccaaggc accggtgtgt gtgtgtcttg     2340



cactccagag ctgacctcca ccgcccagcc tgggaagtca ttgtagggag tgagacactg     2400



aagccctgag aagccagtgc catcatcccc accccgccca gggttccgga acattcattc     2460



ccccaccggt gaggacctgg catgcagcga agcagcccag cccggcggat cccaggccag     2520



cacgcctgcc ggcttctcat cgtcagggag cccgcccaga gctcgtgacg agcaagtgct     2580



gggtccccgc caggcacccc gaggcggcgc tctggctggc agctggtggg gaataggcag     2640



ggcagctgtg gctggggaga gactttaggc agaagctgtg atgcaggctg actgccagcc     2700



gaggggctgg gtagtgccgt gcgggagctg atggtacagg gcactcgctg tccccctccg     2760



gccaccctag accagggtcc gagaggcagg caggagccac tcatgtcttc cccattgccc     2820



gacgcccata gacgctcctt cctgtgtggg gctggggtac tccctggtcg tactgcagtc     2880



agcacccgta acccggctat gaccagggat ctgtaagccc tgtggctcca caggtgctgc     2940



ttctcactgg cccagactct gagctccacc ggcccagtct gcacggccca tctgcttcac     3000



cttccctccc agccacgtgc cagtggccac agcccacttc ccaacccact gttgtaccca     3060



ggcctcactt tgctgttgcc cttgtccctc ttcgggccct gaattttctg ttccctgggg     3120



gccagccagg gccctttgtg cccctcccag cacaggcctg atgcaggtgt ccactcacag     3180



gtggcgctca cctaggctgt cacaggaccc acctccatgc caggcaacag agggccacag     3240



aaccaccccc acggctcact ccttggtctg gggccacctt cttgcccttt cttttttttt     3300



tttttttttt ttttccgaga tggagtctct ctctgtcacc caggtgggag tgtggtggca     3360



caatctcggc tcactgcaac ctccacctcc tgagttcaag caattctcct gcctcagcct     3420



cccaagtagc tgggactaca ggcatgcacc accacacttg gccaatgttc tgtattttta     3480



atagggacgg ggttttgcca tgttagctag gctggtctca aactcacacc tgggattaca     3540



ggcatgagcc actgcaccca gccccttctt gccctttctt ttctccatgg ctgatgctgc     3600



tgtggccagc cagggccctt gagatccttc cagtttggct gttatgcaaa gcaggtgatt     3660



tgtcttaatc agataaaaga tagaggctat gggggcctca agatttttgg agagcagagg     3720



tggtctctgg caattccatc tggttttgag aaacttagca gctcacagag cacagagatc     3780



ctgccttctt cctactatca ggctgaccta atggggttgg gctgctcggc aactgcttgg     3840



gtcaccttgc cccaaggaaa ccagccctgg gtgccaccca gccacttagg gtctacaggg     3900



tgggactcca gacctagagc gtaagtatgg atgttgtggc cctgtgtctt cctagtgtga     3960



cccagccagg agcggaagct tcaggcgttt gtaaagtgag gtctggctct gcctcctccg     4020



tttttttttt ttttctgttt ctgtttctgt tttttttttg agatggagtc tcgctctgtc     4080



gcccaggctg gagtgcagtg tcacgatctc agctcactgc aacctccgcc tcccaggtac     4140



aagagattct cctgcctcag cctcccgagt agctgggact acaggcgtgt gccaccatgc     4200



ctggctaatt tttgtatttt tagtagagat ggggtttcgc catgttagcc agactggtct     4260



cgaactcctg acctcaggtg atcctcccac cccggcttcc caaagttctg ggattatagg     4320



cgtgagccac catgcccggt ctcttctcag tcttgaagcc catccctgga tttccaccag     4380



gagttacttt cctcctgacc tgtaaatttg ttctttaaca atggctgcag gtgggagcat     4440



atggtggttt ataaaaacgc tgtcgggctt tgtttccttc tttagctgcc gtgtctactt     4500



ctgaagtctg ggaagtgcca agccacgcgg cctcaaggga gctggctggt gtttgagctg     4560



tggcagaagc acctggggct ccagggagca ggctgggaac tgcaggacct tgctcagcca     4620



ggagcacttc cccctccttg aggcaggaat actgaggtgc ctccccacag atggagaagg     4680



tggagaggag gatgggcctc aggagcatct caagccccag tagcaggaga aagaaagaaa     4740



gagatgcctg gttttcacag actggttcct gtggctggga tgactgcatc cttttttttt     4800



tttttttgag acggagtttt tgcctttgtc gcccaggctg gagtgcaatg gcgtgatctc     4860



ggctcaccgc aacctccgcc tcccggattc aagcaattct cctgcctcag cctcccgagt     4920



agctgggatt acaggcacgc acctccacgt ccggctaatt ttgtattttt agtggagacg     4980



gggtttctcc atgtcggtca ggctggtctc gaactcccga cctcaggtga tctgcccacc     5040



tcggcctccc aaagtgctgg gattacaggc atgagccacc gcgcttggcc agactgcgtc     5100



ctttttaagc gaacatttta gggcctggga gtttgtcaag taaggaagtc tcaagcccaa     5160



agagcagcgt cctgaccatg gtggtttcat tacgagccct tctgctggct ctcaggcaga     5220



agccccacag caccgggacc attcatgagg tcactgccca gctcatgatg tccgtgaggc     5280



tgtccttttg gccagtagcc gtgtgcagct gtgtggcaca gatggcttcg ttcatcctga     5340



tcaaggcccc acctcagcca cagcagtccc cccaacctgt gttgtccacc ctattattca     5400



tgtacctgcc aggccctgct agatagcacc ccgtggcatt acataacact tcatgagtgg     5460



ctgtgtcttg taattttggg gacaggtttc tctctttccc tctctttttt ttgtcaaaag     5520



cccagagact gacaaccagc tgcagtgtct aagtgttcct cactgacagg gtggggcctc     5580



accacccctg gagggagcag cgttggcagg gagacagcct ggcccagtga ccctgggccc     5640



aagccagccc ctccagggct ttcagggaag cgccatccat tttcaaagat gtcaaacgtc     5700



acttcttcct gtagggcccg agtcctgcct cctatcaggg ccagatcata gaaggctatt     5760



ttctattctg gggaacgatt ataacttaaa tgattgtttt aataaaaatt ctaagctgga     5820



aaataaaaaa aaaaaaaaaa aa                                              5842





<210>  171

<211>  507

<212>  PRT

<213>  Homo sapiens



<400>  171



Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 

1               5                   10                  15      





Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 

            20                  25                  30          





Met Glu Phe Asn Cys Glu Val Lys Lys Gln Ile Leu Asp Glu Lys Ile 

        35                  40                  45              





Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr Ala Val Gln 

    50                  55                  60                  





Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg Gly Phe Leu 

65                  70                  75                  80  





Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu Tyr Gln Met 

                85                  90                  95      





Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr Ala Glu His 

            100                 105                 110         





Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu Lys Ile Ala 

        115                 120                 125             





Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile Arg Asn Lys 

    130                 135                 140                 





Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly Leu His Ile 

145                 150                 155                 160 





Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe Pro Trp Asn 

                165                 170                 175     





Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr Ile Lys Pro 

            180                 185                 190         





Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser Lys Leu Arg 

        195                 200                 205             





Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His Asp Leu Phe 

    210                 215                 220                 





Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln Met Lys Ala 

225                 230                 235                 240 





Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg Gln Arg Leu 

                245                 250                 255     





Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr Arg Asp Glu 

            260                 265                 270         





Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr Met Ala Asn 

        275                 280                 285             





Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu Ala Glu Lys 

    290                 295                 300                 





Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln Lys Ala Ala 

305                 310                 315                 320 





Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala Ile Arg Thr 

                325                 330                 335     





Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu Ala Glu Val 

            340                 345                 350         





Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala Lys Glu Ala 

        355                 360                 365             





Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala Glu Arg Arg 

    370                 375                 380                 





Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr Tyr Pro Pro 

385                 390                 395                 400 





Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro Ser Phe Asn 

                405                 410                 415     





Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr Asp Met Lys 

            420                 425                 430         





Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr Met Glu Lys 

        435                 440                 445             





Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr Glu Ile Glu 

    450                 455                 460                 





Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile Leu His Asn 

465                 470                 475                 480 





Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr Ile Lys Lys 

                485                 490                 495     





Pro Gln Ala Gln Gly Arg Arg Pro Ile Cys Ile 

            500                 505         





<210>  172

<211>  2217

<212>  DNA

<213>  Homo sapiens



<400>  172

tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc cacgcgcgcg cgtacgcgcc       60



cgatgcagcg cggccccgtg accctagtcg gccgctgaga ggcgcgcgga gtctgggccg      120



ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc tccggcccga atcccggagt      180



gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc ctccctgcag ccgtcagggc      240



ccgtccccca actccccttt ccgctcaggc agggtcctcg cggcccatgc tggccgctgg      300



ggacccgcgc agcccagacc gttcccgggc cgggcagccg gccaccatgg tggccctgag      360



gcctgtgcag caactccagg ggggctaaag ggctcagagt gcaggccgtg gggcgcgagg      420



gtcccgggcc tgagccccgc gccatggccg gggccatcgc ttcccgcatg agcttcagct      480



ctctcaagag gaagcaaccc aagacgttca ccgtgaggat cgtcaccatg gacgccgaga      540



tggagttcaa ttgcgaggta aagaagcaga ttttagatga aaagatctac tgccctcctg      600



aggcttctgt gctcctggct tcttacgccg tccaggccaa gtatggtgac tacgacccca      660



gtgttcacaa gcggggattt ttggcccaag aggaattgct tccaaaaagg gtaataaatc      720



tgtatcagat gactccggaa atgtgggagg agagaattac tgcttggtac gcagagcacc      780



gaggccgagc cagggatgaa gctgaaatgg aatatctgaa gatagctcag gacctggaga      840



tgtacggtgt gaactacttt gcaatccgga ataaaaaggg cacagagctg ctgcttggag      900



tggatgccct ggggcttcac atttatgacc ctgagaacag actgaccccc aagatctcct      960



tcccgtggaa tgaaatccga aacatctcgt acagtgacaa ggagtttact attaaaccac     1020



tggataagaa aattgatgtc ttcaagttta actcctcaaa gcttcgtgtt aataagctga     1080



ttctccagct atgtatcggg aaccatgatc tatttatgag gagaaggaaa gccgattctt     1140



tggaagttca gcagatgaaa gcccaggcca gggaggagaa ggctagaaag cagatggagc     1200



ggcagcgcct cgctcgagag aagcagatga gggaggaggc tgaacgcacg agggatgagt     1260



tggagaggag gctgctgcag atgaaagaag aagcaacaat ggccaacgaa gcactgatgc     1320



ggtctgagga gacagctgac ctgttggctg aaaaggccca gatcaccgag gaggaggcaa     1380



aacttctggc ccagaaggcc gcagaggctg agcaggaaat gcagcgcatc aaggccacag     1440



cgattcgcac ggaggaggag aagcgcctga tggagcagaa ggtgctggaa gccgaggtgc     1500



tggcactgaa gatggctgag gagtcagaga ggagggccaa agaggcagat cagctgaagc     1560



aggacctgca ggaagcacgc gaggcggagc gaagagccaa gcagaagctc ctggagattg     1620



ccaccaagcc cacgtacccg cccatgaacc caattccagc accgttgcct cctgacatac     1680



caagcttcaa cctcattggt gacagcctgt ctttcgactt caaagatact gacatgaagc     1740



ggctttccat ggagatagag aaagaaaaag tggaatacat ggaaaagagc aagcatctgc     1800



aggagcagct caatgaactc aagacagaaa tcgaggcctt gaaactgaaa gagagggaga     1860



cagctctgga tattctgcac aatgagaact ccgacagggg tggcagcagc aagcacaata     1920



ccattaaaaa gcctcaagcc caaggcagaa gacctatctg catttgagcc ctcaaacttc     1980



ctctccatag gctgagcaga gatgtggtca gagtgaactc acattggaac agtacactca     2040



cggcaccctg gagaggagcg gtcactggtt gctgagtgaa ttaaccgaat gtttgctgct     2100



tttctcctgc aacagttcat tattcctcca gcatgcctag gcagtggaga gaatgtattt     2160



tgcccaataa taaaatgaca tcctgcctct aaaaaaaaaa aaaaaaaaaa aaaaaaa        2217





<210>  173

<211>  507

<212>  PRT

<213>  Homo sapiens



<400>  173



Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 

1               5                   10                  15      





Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 

            20                  25                  30          





Met Glu Phe Asn Cys Glu Val Lys Lys Gln Ile Leu Asp Glu Lys Ile 

        35                  40                  45              





Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr Ala Val Gln 

    50                  55                  60                  





Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg Gly Phe Leu 

65                  70                  75                  80  





Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu Tyr Gln Met 

                85                  90                  95      





Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr Ala Glu His 

            100                 105                 110         





Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu Lys Ile Ala 

        115                 120                 125             





Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile Arg Asn Lys 

    130                 135                 140                 





Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly Leu His Ile 

145                 150                 155                 160 





Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe Pro Trp Asn 

                165                 170                 175     





Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr Ile Lys Pro 

            180                 185                 190         





Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser Lys Leu Arg 

        195                 200                 205             





Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His Asp Leu Phe 

    210                 215                 220                 





Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln Met Lys Ala 

225                 230                 235                 240 





Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg Gln Arg Leu 

                245                 250                 255     





Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr Arg Asp Glu 

            260                 265                 270         





Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr Met Ala Asn 

        275                 280                 285             





Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu Ala Glu Lys 

    290                 295                 300                 





Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln Lys Ala Ala 

305                 310                 315                 320 





Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala Ile Arg Thr 

                325                 330                 335     





Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu Ala Glu Val 

            340                 345                 350         





Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala Lys Glu Ala 

        355                 360                 365             





Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala Glu Arg Arg 

    370                 375                 380                 





Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr Tyr Pro Pro 

385                 390                 395                 400 





Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro Ser Phe Asn 

                405                 410                 415     





Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr Asp Met Lys 

            420                 425                 430         





Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr Met Glu Lys 

        435                 440                 445             





Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr Glu Ile Glu 

    450                 455                 460                 





Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile Leu His Asn 

465                 470                 475                 480 





Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr Ile Lys Lys 

                485                 490                 495     





Pro Gln Ala Gln Gly Arg Arg Pro Ile Cys Ile 

            500                 505         





<210>  174

<211>  6106

<212>  DNA

<213>  Homo sapiens



<400>  174

tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc cacgcgcgcg cgtacgcgcc       60



cgatgcagcg cggccccgtg accctagtcg gccgctgaga ggcgcgcgga gtctgggccg      120



ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc tccggcccga atcccggagt      180



gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc ctccctgcag ccgtcagggc      240



ccgtccccca actccccttt ccgctcaggc agggtcctcg cggcccatgc tggccgctgg      300



ggacccgcgc agcccagacc gttcccgggc cgggcagccg gccaccatgg tggccctgag      360



gcctgtgcag caactccagg ggggctaaag ggctcagagt gcaggccgtg gggcgcgagg      420



gtcccgggcc tgagccccgc gccatggccg gggccatcgc ttcccgcatg agcttcagct      480



ctctcaagag gaagcaaccc aagacgttca ccgtgaggat cgtcaccatg gacgccgaga      540



tggagttcaa ttgcgagatg aagtggaaag ggaaggacct ctttgatttg gtgtgccgga      600



ctctggggct ccgagaaacc tggttctttg gactgcagta cacaatcaag gacacagtgg      660



cctggctcaa aatggacaag aaggtactgg atcatgatgt ttcaaaggaa gaaccagtca      720



cctttcactt cttggccaaa ttttatcctg agaatgctga agaggagctg gttcaggaga      780



tcacacaaca tttattcttc ttacaggtaa agaagcagat tttagatgaa aagatctact      840



gccctcctga ggcttctgtg ctcctggctt cttacgccgt ccaggccaag tatggtgact      900



acgaccccag tgttcacaag cggggatttt tggcccaaga ggaattgctt ccaaaaaggg      960



taataaatct gtatcagatg actccggaaa tgtgggagga gagaattact gcttggtacg     1020



cagagcaccg aggccgagcc agggatgaag ctgaaatgga atatctgaag atagctcagg     1080



acctggagat gtacggtgtg aactactttg caatccggaa taaaaagggc acagagctgc     1140



tgcttggagt ggatgccctg gggcttcaca tttatgaccc tgagaacaga ctgaccccca     1200



agatctcctt cccgtggaat gaaatccgaa acatctcgta cagtgacaag gagtttacta     1260



ttaaaccact ggataagaaa attgatgtct tcaagtttaa ctcctcaaag cttcgtgtta     1320



ataagctgat tctccagcta tgtatcggga accatgatct atttatgagg agaaggaaag     1380



ccgattcttt ggaagttcag cagatgaaag cccaggccag ggaggagaag gctagaaagc     1440



agatggagcg gcagcgcctc gctcgagaga agcagatgag ggaggaggct gaacgcacga     1500



gggatgagtt ggagaggagg ctgctgcaga tgaaagaaga agcaacaatg gccaacgaag     1560



cactgatgcg gtctgaggag acagctgacc tgttggctga aaaggcccag atcaccgagg     1620



aggaggcaaa acttctggcc cagaaggccg cagaggctga gcaggaaatg cagcgcatca     1680



aggccacagc gattcgcacg gaggaggaga agcgcctgat ggagcagaag gtgctggaag     1740



ccgaggtgct ggcactgaag atggctgagg agtcagagag gagggccaaa gaggcagatc     1800



agctgaagca ggacctgcag gaagcacgcg aggcggagcg aagagccaag cagaagctcc     1860



tggagattgc caccaagccc acgtacccgc ccatgaaccc aattccagca ccgttgcctc     1920



ctgacatacc aagcttcaac ctcattggtg acagcctgtc tttcgacttc aaagatactg     1980



acatgaagcg gctttccatg gagatagaga aagaaaaagt ggaatacatg gaaaagagca     2040



agcatctgca ggagcagctc aatgaactca agacagaaat cgaggccttg aaactgaaag     2100



agagggagac agctctggat attctgcaca atgagaactc cgacaggggt ggcagcagca     2160



agcacaatac cattaaaaag cctcaagccc aaggcagaag acctatctgc atttgagccc     2220



tcaaagtagg ttgttcccag ctcaccttgc agagcgccaa gtcccgagtg gccttctttg     2280



aagagctcta gcaggtgacc cagccacccc aggacctgcc acttctcctg ctaccgggac     2340



cgcgggatgg accagatatc aagagagcca tccataggga gctggctggg ggtttccgtg     2400



ggagctccag aactttcccc agctgagtga agagcccagc ccctcttatg tgcaattgcc     2460



ttgaactacg accctgtaga gatttctctc atggcgttct agttctctga cctgagtctt     2520



tgttttaaga agtatttgtc ttcctttgtc taatgtggga ttcctgactc ccttcgtcca     2580



aggcaccggt gtgtgtgtgt cttgcactcc agagctgacc tccaccgccc agcctgggaa     2640



gtcattgtag ggagtgagac actgaagccc tgagaagcca gtgccatcat ccccaccccg     2700



cccagggttc cggaacattc attcccccac cggtgaggac ctggcatgca gcgaagcagc     2760



ccagcccggc ggatcccagg ccagcacgcc tgccggcttc tcatcgtcag ggagcccgcc     2820



cagagctcgt gacgagcaag tgctgggtcc ccgccaggca ccccgaggcg gcgctctggc     2880



tggcagctgg tggggaatag gcagggcagc tgtggctggg gagagacttt aggcagaagc     2940



tgtgatgcag gctgactgcc agccgagggg ctgggtagtg ccgtgcggga gctgatggta     3000



cagggcactc gctgtccccc tccggccacc ctagaccagg gtccgagagg caggcaggag     3060



ccactcatgt cttccccatt gcccgacgcc catagacgct ccttcctgtg tggggctggg     3120



gtactccctg gtcgtactgc agtcagcacc cgtaacccgg ctatgaccag ggatctgtaa     3180



gccctgtggc tccacaggtg ctgcttctca ctggcccaga ctctgagctc caccggccca     3240



gtctgcacgg cccatctgct tcaccttccc tcccagccac gtgccagtgg ccacagccca     3300



cttcccaacc cactgttgta cccaggcctc actttgctgt tgcccttgtc cctcttcggg     3360



ccctgaattt tctgttccct gggggccagc cagggccctt tgtgcccctc ccagcacagg     3420



cctgatgcag gtgtccactc acaggtggcg ctcacctagg ctgtcacagg acccacctcc     3480



atgccaggca acagagggcc acagaaccac ccccacggct cactccttgg tctggggcca     3540



ccttcttgcc ctttcttttt tttttttttt ttttttttcc gagatggagt ctctctctgt     3600



cacccaggtg ggagtgtggt ggcacaatct cggctcactg caacctccac ctcctgagtt     3660



caagcaattc tcctgcctca gcctcccaag tagctgggac tacaggcatg caccaccaca     3720



cttggccaat gttctgtatt tttaataggg acggggtttt gccatgttag ctaggctggt     3780



ctcaaactca cacctgggat tacaggcatg agccactgca cccagcccct tcttgccctt     3840



tcttttctcc atggctgatg ctgctgtggc cagccagggc ccttgagatc cttccagttt     3900



ggctgttatg caaagcaggt gatttgtctt aatcagataa aagatagagg ctatgggggc     3960



ctcaagattt ttggagagca gaggtggtct ctggcaattc catctggttt tgagaaactt     4020



agcagctcac agagcacaga gatcctgcct tcttcctact atcaggctga cctaatgggg     4080



ttgggctgct cggcaactgc ttgggtcacc ttgccccaag gaaaccagcc ctgggtgcca     4140



cccagccact tagggtctac agggtgggac tccagaccta gagcgtaagt atggatgttg     4200



tggccctgtg tcttcctagt gtgacccagc caggagcgga agcttcaggc gtttgtaaag     4260



tgaggtctgg ctctgcctcc tccgtttttt ttttttttct gtttctgttt ctgttttttt     4320



tttgagatgg agtctcgctc tgtcgcccag gctggagtgc agtgtcacga tctcagctca     4380



ctgcaacctc cgcctcccag gtacaagaga ttctcctgcc tcagcctccc gagtagctgg     4440



gactacaggc gtgtgccacc atgcctggct aatttttgta tttttagtag agatggggtt     4500



tcgccatgtt agccagactg gtctcgaact cctgacctca ggtgatcctc ccaccccggc     4560



ttcccaaagt tctgggatta taggcgtgag ccaccatgcc cggtctcttc tcagtcttga     4620



agcccatccc tggatttcca ccaggagtta ctttcctcct gacctgtaaa tttgttcttt     4680



aacaatggct gcaggtggga gcatatggtg gtttataaaa acgctgtcgg gctttgtttc     4740



cttctttagc tgccgtgtct acttctgaag tctgggaagt gccaagccac gcggcctcaa     4800



gggagctggc tggtgtttga gctgtggcag aagcacctgg ggctccaggg agcaggctgg     4860



gaactgcagg accttgctca gccaggagca cttccccctc cttgaggcag gaatactgag     4920



gtgcctcccc acagatggag aaggtggaga ggaggatggg cctcaggagc atctcaagcc     4980



ccagtagcag gagaaagaaa gaaagagatg cctggttttc acagactggt tcctgtggct     5040



gggatgactg catccttttt tttttttttt tgagacggag tttttgcctt tgtcgcccag     5100



gctggagtgc aatggcgtga tctcggctca ccgcaacctc cgcctcccgg attcaagcaa     5160



ttctcctgcc tcagcctccc gagtagctgg gattacaggc acgcacctcc acgtccggct     5220



aattttgtat ttttagtgga gacggggttt ctccatgtcg gtcaggctgg tctcgaactc     5280



ccgacctcag gtgatctgcc cacctcggcc tcccaaagtg ctgggattac aggcatgagc     5340



caccgcgctt ggccagactg cgtccttttt aagcgaacat tttagggcct gggagtttgt     5400



caagtaagga agtctcaagc ccaaagagca gcgtcctgac catggtggtt tcattacgag     5460



cccttctgct ggctctcagg cagaagcccc acagcaccgg gaccattcat gaggtcactg     5520



cccagctcat gatgtccgtg aggctgtcct tttggccagt agccgtgtgc agctgtgtgg     5580



cacagatggc ttcgttcatc ctgatcaagg ccccacctca gccacagcag tccccccaac     5640



ctgtgttgtc caccctatta ttcatgtacc tgccaggccc tgctagatag caccccgtgg     5700



cattacataa cacttcatga gtggctgtgt cttgtaattt tggggacagg tttctctctt     5760



tccctctctt ttttttgtca aaagcccaga gactgacaac cagctgcagt gtctaagtgt     5820



tcctcactga cagggtgggg cctcaccacc cctggaggga gcagcgttgg cagggagaca     5880



gcctggccca gtgaccctgg gcccaagcca gcccctccag ggctttcagg gaagcgccat     5940



ccattttcaa agatgtcaaa cgtcacttct tcctgtaggg cccgagtcct gcctcctatc     6000



agggccagat catagaaggc tattttctat tctggggaac gattataact taaatgattg     6060



ttttaataaa aattctaagc tggaaaataa aaaaaaaaaa aaaaaa                    6106





<210>  175

<211>  590

<212>  PRT

<213>  Homo sapiens



<400>  175



Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 

1               5                   10                  15      





Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 

            20                  25                  30          





Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp 

        35                  40                  45              





Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu 

    50                  55                  60                  





Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys 

65                  70                  75                  80  





Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe 

                85                  90                  95      





Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu 

            100                 105                 110         





Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp 

        115                 120                 125             





Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr 

    130                 135                 140                 





Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg 

145                 150                 155                 160 





Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu 

                165                 170                 175     





Tyr Gln Met Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr 

            180                 185                 190         





Ala Glu His Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu 

        195                 200                 205             





Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile 

    210                 215                 220                 





Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly 

225                 230                 235                 240 





Leu His Ile Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe 

                245                 250                 255     





Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr 

            260                 265                 270         





Ile Lys Pro Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser 

        275                 280                 285             





Lys Leu Arg Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His 

    290                 295                 300                 





Asp Leu Phe Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln 

305                 310                 315                 320 





Met Lys Ala Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg 

                325                 330                 335     





Gln Arg Leu Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr 

            340                 345                 350         





Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr 

        355                 360                 365             





Met Ala Asn Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu 

    370                 375                 380                 





Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln 

385                 390                 395                 400 





Lys Ala Ala Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala 

                405                 410                 415     





Ile Arg Thr Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu 

            420                 425                 430         





Ala Glu Val Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala 

        435                 440                 445             





Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala 

    450                 455                 460                 





Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr 

465                 470                 475                 480 





Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro 

                485                 490                 495     





Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr 

            500                 505                 510         





Asp Met Lys Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr 

        515                 520                 525             





Met Glu Lys Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr 

    530                 535                 540                 





Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile 

545                 550                 555                 560 





Leu His Asn Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr 

                565                 570                 575     





Ile Lys Lys Pro Gln Ala Gln Gly Arg Arg Pro Ile Cys Ile 

            580                 585                 590 





<210>  176

<211>  4756

<212>  DNA

<213>  Homo sapiens



<400>  176

tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc cacgcgcgcg cgtacgcgcc       60



cgatgcagcg cggccccgtg accctagtcg gccgctgaga ggcgcgcgga gtctgggccg      120



ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc tccggcccga atcccggagt      180



gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc ctccctgcag ccgtcagggc      240



ccgtccccca actccccttt ccgctcaggc agggtcctcg cggcccatgc tggccgctgg      300



ggacccgcgc agcccagacc gttcccgggc cgggcagccg gccaccatgg tggccctgag      360



gcctgtgcag caactccagg ggggctaaag ggctcagagt gcaggccgtg gggcgcgagg      420



gtcccgggcc tgagccccgc gccatggccg gggccatcgc ttcccgcatg agcttcagct      480



ctctcaagag gaagcaaccc aagacgttca ccgtgaggat cgtcaccatg gacgccgaga      540



tggagttcaa ttgcgagatg aagtggaaag ggaaggacct ctttgatttg gtgtgccgga      600



ctctggggct ccgagaaacc tggttctttg gactgcagta cacaatcaag gacacagtgg      660



cctggctcaa aatggacaag aaggtactgg atcatgatgt ttcaaaggaa gaaccagtca      720



cctttcactt cttggccaaa ttttatcctg agaatgctga agaggagctg gttcaggaga      780



tcacacaaca tttattcttc ttacaggtaa agaagcagat tttagatgaa aagatctact      840



gccctcctga ggcttctgtg ctcctggctt cttacgccgt ccaggccaag ctcaccttgc      900



agagcgccaa gtcccgagtg gccttctttg aagagctcta gcaggtgacc cagccacccc      960



aggacctgcc acttctcctg ctaccgggac cgcgggatgg accagatatc aagagagcca     1020



tccataggga gctggctggg ggtttccgtg ggagctccag aactttcccc agctgagtga     1080



agagcccagc ccctcttatg tgcaattgcc ttgaactacg accctgtaga gatttctctc     1140



atggcgttct agttctctga cctgagtctt tgttttaaga agtatttgtc ttcctttgtc     1200



taatgtggga ttcctgactc ccttcgtcca aggcaccggt gtgtgtgtgt cttgcactcc     1260



agagctgacc tccaccgccc agcctgggaa gtcattgtag ggagtgagac actgaagccc     1320



tgagaagcca gtgccatcat ccccaccccg cccagggttc cggaacattc attcccccac     1380



cggtgaggac ctggcatgca gcgaagcagc ccagcccggc ggatcccagg ccagcacgcc     1440



tgccggcttc tcatcgtcag ggagcccgcc cagagctcgt gacgagcaag tgctgggtcc     1500



ccgccaggca ccccgaggcg gcgctctggc tggcagctgg tggggaatag gcagggcagc     1560



tgtggctggg gagagacttt aggcagaagc tgtgatgcag gctgactgcc agccgagggg     1620



ctgggtagtg ccgtgcggga gctgatggta cagggcactc gctgtccccc tccggccacc     1680



ctagaccagg gtccgagagg caggcaggag ccactcatgt cttccccatt gcccgacgcc     1740



catagacgct ccttcctgtg tggggctggg gtactccctg gtcgtactgc agtcagcacc     1800



cgtaacccgg ctatgaccag ggatctgtaa gccctgtggc tccacaggtg ctgcttctca     1860



ctggcccaga ctctgagctc caccggccca gtctgcacgg cccatctgct tcaccttccc     1920



tcccagccac gtgccagtgg ccacagccca cttcccaacc cactgttgta cccaggcctc     1980



actttgctgt tgcccttgtc cctcttcggg ccctgaattt tctgttccct gggggccagc     2040



cagggccctt tgtgcccctc ccagcacagg cctgatgcag gtgtccactc acaggtggcg     2100



ctcacctagg ctgtcacagg acccacctcc atgccaggca acagagggcc acagaaccac     2160



ccccacggct cactccttgg tctggggcca ccttcttgcc ctttcttttt tttttttttt     2220



ttttttttcc gagatggagt ctctctctgt cacccaggtg ggagtgtggt ggcacaatct     2280



cggctcactg caacctccac ctcctgagtt caagcaattc tcctgcctca gcctcccaag     2340



tagctgggac tacaggcatg caccaccaca cttggccaat gttctgtatt tttaataggg     2400



acggggtttt gccatgttag ctaggctggt ctcaaactca cacctgggat tacaggcatg     2460



agccactgca cccagcccct tcttgccctt tcttttctcc atggctgatg ctgctgtggc     2520



cagccagggc ccttgagatc cttccagttt ggctgttatg caaagcaggt gatttgtctt     2580



aatcagataa aagatagagg ctatgggggc ctcaagattt ttggagagca gaggtggtct     2640



ctggcaattc catctggttt tgagaaactt agcagctcac agagcacaga gatcctgcct     2700



tcttcctact atcaggctga cctaatgggg ttgggctgct cggcaactgc ttgggtcacc     2760



ttgccccaag gaaaccagcc ctgggtgcca cccagccact tagggtctac agggtgggac     2820



tccagaccta gagcgtaagt atggatgttg tggccctgtg tcttcctagt gtgacccagc     2880



caggagcgga agcttcaggc gtttgtaaag tgaggtctgg ctctgcctcc tccgtttttt     2940



ttttttttct gtttctgttt ctgttttttt tttgagatgg agtctcgctc tgtcgcccag     3000



gctggagtgc agtgtcacga tctcagctca ctgcaacctc cgcctcccag gtacaagaga     3060



ttctcctgcc tcagcctccc gagtagctgg gactacaggc gtgtgccacc atgcctggct     3120



aatttttgta tttttagtag agatggggtt tcgccatgtt agccagactg gtctcgaact     3180



cctgacctca ggtgatcctc ccaccccggc ttcccaaagt tctgggatta taggcgtgag     3240



ccaccatgcc cggtctcttc tcagtcttga agcccatccc tggatttcca ccaggagtta     3300



ctttcctcct gacctgtaaa tttgttcttt aacaatggct gcaggtggga gcatatggtg     3360



gtttataaaa acgctgtcgg gctttgtttc cttctttagc tgccgtgtct acttctgaag     3420



tctgggaagt gccaagccac gcggcctcaa gggagctggc tggtgtttga gctgtggcag     3480



aagcacctgg ggctccaggg agcaggctgg gaactgcagg accttgctca gccaggagca     3540



cttccccctc cttgaggcag gaatactgag gtgcctcccc acagatggag aaggtggaga     3600



ggaggatggg cctcaggagc atctcaagcc ccagtagcag gagaaagaaa gaaagagatg     3660



cctggttttc acagactggt tcctgtggct gggatgactg catccttttt tttttttttt     3720



tgagacggag tttttgcctt tgtcgcccag gctggagtgc aatggcgtga tctcggctca     3780



ccgcaacctc cgcctcccgg attcaagcaa ttctcctgcc tcagcctccc gagtagctgg     3840



gattacaggc acgcacctcc acgtccggct aattttgtat ttttagtgga gacggggttt     3900



ctccatgtcg gtcaggctgg tctcgaactc ccgacctcag gtgatctgcc cacctcggcc     3960



tcccaaagtg ctgggattac aggcatgagc caccgcgctt ggccagactg cgtccttttt     4020



aagcgaacat tttagggcct gggagtttgt caagtaagga agtctcaagc ccaaagagca     4080



gcgtcctgac catggtggtt tcattacgag cccttctgct ggctctcagg cagaagcccc     4140



acagcaccgg gaccattcat gaggtcactg cccagctcat gatgtccgtg aggctgtcct     4200



tttggccagt agccgtgtgc agctgtgtgg cacagatggc ttcgttcatc ctgatcaagg     4260



ccccacctca gccacagcag tccccccaac ctgtgttgtc caccctatta ttcatgtacc     4320



tgccaggccc tgctagatag caccccgtgg cattacataa cacttcatga gtggctgtgt     4380



cttgtaattt tggggacagg tttctctctt tccctctctt ttttttgtca aaagcccaga     4440



gactgacaac cagctgcagt gtctaagtgt tcctcactga cagggtgggg cctcaccacc     4500



cctggaggga gcagcgttgg cagggagaca gcctggccca gtgaccctgg gcccaagcca     4560



gcccctccag ggctttcagg gaagcgccat ccattttcaa agatgtcaaa cgtcacttct     4620



tcctgtaggg cccgagtcct gcctcctatc agggccagat catagaaggc tattttctat     4680



tctggggaac gattataact taaatgattg ttttaataaa aattctaagc tggaaaataa     4740



aaaaaaaaaa aaaaaa                                                     4756





<210>  177

<211>  165

<212>  PRT

<213>  Homo sapiens



<400>  177



Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 

1               5                   10                  15      





Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 

            20                  25                  30          





Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp 

        35                  40                  45              





Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu 

    50                  55                  60                  





Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys 

65                  70                  75                  80  





Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe 

                85                  90                  95      





Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu 

            100                 105                 110         





Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp 

        115                 120                 125             





Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr 

    130                 135                 140                 





Ala Val Gln Ala Lys Leu Thr Leu Gln Ser Ala Lys Ser Arg Val Ala 

145                 150                 155                 160 





Phe Phe Glu Glu Leu 

                165 





<210>  178

<211>  2545

<212>  DNA

<213>  Homo sapiens



<400>  178

ggaccccgcc cctgccggtg gctgcggtag ctgctgcgcg ctgaggcgcc tgctcagtgt       60



gggacgcgga gagcgagggg cggcggcggc gcccgctggc gctcaagcat ggcggcggcg      120



gcattgggca gctcctcagg ctcggcgtcc ccggccgtgg ctgagctctg ccagaacacc      180



ccggagacct ttttggaggc ctccaagctg ctgctcacct atgctgacaa catcctcaga      240



aaccctaatg atgaaaaata tagatccatc cggattggaa acacagcctt ttctactaga      300



ctcttgcctg tcagaggagc tgttgaatgt ttatttgaaa tgggctttga agagggagaa      360



acacatctca tctttcctaa aaaagcttca gtggagcagc tgcaaaaaat tcgtgacctg      420



attgccatag agagaagtag cagactggat ggctcaaata agagccacaa agtaaagtca      480



tctcagcaac ctgcagccag tacccagctt cctacaacac catcttcaaa tcccagtggg      540



ttaaaccagc acacaaggaa ccgtcaaggg cagtcatcag atccaccatc tgcttcaacg      600



gttgctgctg actcagccat tctagaagtt cttcagtcca acattcagca tgtgctggtc      660



tatgaaaatc ctgctcttca ggagaaagcg ttggcttgta ttccggtcca agaactaaaa      720



aggaaatcac aagaaaagtt atcgagagct agaaaattgg ataaaggtat caatataagt      780



gatgaggatt ttcttttgct ggagcttttg cactggttta aggaagaatt ttttcactgg      840



gtgaataacg ttttgtgcag caaatgtggt ggacagacta ggtctagaga tagatcatta      900



ctgcccagtg atgatgagct gaagtggggt gcaaaggaag tggaagatca ttactgtgat      960



gcctgccagt tcagcaatcg attcccaaga tataataacc ctgagaaact tttggaaaca     1020



agatgtggac ggtgtggcga gtgggccaat tgttttacac tgtgctgccg agctgtaggg     1080



tttgaagctc gctatgtttg ggattacaca gagttacagc gcacattaag cctaaaactg     1140



accacgttaa aggagattgg aaaaacattt ttaaggattt caaagagaca gaaattaata     1200



caggtagttg atgtcacttg gcgatattcc tgcaaacatg aagaggtgat tgccagaaga     1260



actaaggtta aagaagcatt acttcgagac actattaatg ggcttaataa gcagaggcaa     1320



ctgtttttgt cagaaaacag aaggaaagaa cttctccaga ggataattgt ggagcttgtt     1380



gaatttatat ctcccaaaac ccctaaacct ggagaacttg ggggaagaat atctgggtca     1440



gtggcttgga gagtagcccg aggtgaaatg ggtctacaga gaaaagaaac cttgtttatt     1500



ccctgtgaaa atgagaagat ttctaaacag ctccaccttt gttacaatat tgtgaaagat     1560



cgttatgttc gagtttcaaa taacaatcaa accatttctg gatgggagaa tggcgtgtgg     1620



aaaatggaat ctatattcag aaaagttgaa acagactggc acatggtata tttggcccga     1680



aaggaaggat catcttttgc ttatatttcc tggaagtttg agtgtgggtc agttggccta     1740



aaagtagata gcatttctat tagaacaagt agtcaaactt ttcagactgg aacagtagaa     1800



tggaaattgc gatctgatac agcacaagta gaactgacag gcgataacag tcttcactcc     1860



tatgctgatt tttctggtgc cactgaagtt attttggaag cagaattaag cagaggagat     1920



ggtgatgtcg cttggcaaca cacccagctg tttagacaaa gcttaaatga ccatgaagaa     1980



aattgtttgg agataattat aaaattcagt gacctttgag aacctgaaca ttatagaaaa     2040



gctggcaata atcaaggact tactgaagta gtctgttggt tcagtgcatg cttagttggc     2100



agttaccacc ctgtgctagc atatttcttt tgctagctat ccatcatgta accctcatga     2160



aaattatctt tatacgtgga ctataataaa atattgaatt aaaacctttc ttccatatgt     2220



gactataatt tggagtaaag tcttgttgac tcaatatggg attttaatct aaaactgtaa     2280



gtatggtttt aaaagttaaa taatgatatt catgattaaa tgctattcat gattatgata     2340



aaatcttggg cttatgatag taatttgaca ttttctgatc agccattcat ttcttcagaa     2400



gtggttaaat tagagtctcc taatattttt aattaatgtg aaagtacagt agctcataaa     2460



ttatataatg catgaaaatt tatatgatta taaatattca ggcatttaag aaataaaatg     2520



aagtattttg ccttaaaaaa aaaaa                                           2545





<210>  179

<211>  636

<212>  PRT

<213>  Homo sapiens



<400>  179



Met Ala Ala Ala Ala Leu Gly Ser Ser Ser Gly Ser Ala Ser Pro Ala 

1               5                   10                  15      





Val Ala Glu Leu Cys Gln Asn Thr Pro Glu Thr Phe Leu Glu Ala Ser 

            20                  25                  30          





Lys Leu Leu Leu Thr Tyr Ala Asp Asn Ile Leu Arg Asn Pro Asn Asp 

        35                  40                  45              





Glu Lys Tyr Arg Ser Ile Arg Ile Gly Asn Thr Ala Phe Ser Thr Arg 

    50                  55                  60                  





Leu Leu Pro Val Arg Gly Ala Val Glu Cys Leu Phe Glu Met Gly Phe 

65                  70                  75                  80  





Glu Glu Gly Glu Thr His Leu Ile Phe Pro Lys Lys Ala Ser Val Glu 

                85                  90                  95      





Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg Ser Ser Arg 

            100                 105                 110         





Leu Asp Gly Ser Asn Lys Ser His Lys Val Lys Ser Ser Gln Gln Pro 

        115                 120                 125             





Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn Pro Ser Gly 

    130                 135                 140                 





Leu Asn Gln His Thr Arg Asn Arg Gln Gly Gln Ser Ser Asp Pro Pro 

145                 150                 155                 160 





Ser Ala Ser Thr Val Ala Ala Asp Ser Ala Ile Leu Glu Val Leu Gln 

                165                 170                 175     





Ser Asn Ile Gln His Val Leu Val Tyr Glu Asn Pro Ala Leu Gln Glu 

            180                 185                 190         





Lys Ala Leu Ala Cys Ile Pro Val Gln Glu Leu Lys Arg Lys Ser Gln 

        195                 200                 205             





Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp Lys Gly Ile Asn Ile Ser 

    210                 215                 220                 





Asp Glu Asp Phe Leu Leu Leu Glu Leu Leu His Trp Phe Lys Glu Glu 

225                 230                 235                 240 





Phe Phe His Trp Val Asn Asn Val Leu Cys Ser Lys Cys Gly Gly Gln 

                245                 250                 255     





Thr Arg Ser Arg Asp Arg Ser Leu Leu Pro Ser Asp Asp Glu Leu Lys 

            260                 265                 270         





Trp Gly Ala Lys Glu Val Glu Asp His Tyr Cys Asp Ala Cys Gln Phe 

        275                 280                 285             





Ser Asn Arg Phe Pro Arg Tyr Asn Asn Pro Glu Lys Leu Leu Glu Thr 

    290                 295                 300                 





Arg Cys Gly Arg Cys Gly Glu Trp Ala Asn Cys Phe Thr Leu Cys Cys 

305                 310                 315                 320 





Arg Ala Val Gly Phe Glu Ala Arg Tyr Val Trp Asp Tyr Thr Glu Leu 

                325                 330                 335     





Gln Arg Thr Leu Ser Leu Lys Leu Thr Thr Leu Lys Glu Ile Gly Lys 

            340                 345                 350         





Thr Phe Leu Arg Ile Ser Lys Arg Gln Lys Leu Ile Gln Val Val Asp 

        355                 360                 365             





Val Thr Trp Arg Tyr Ser Cys Lys His Glu Glu Val Ile Ala Arg Arg 

    370                 375                 380                 





Thr Lys Val Lys Glu Ala Leu Leu Arg Asp Thr Ile Asn Gly Leu Asn 

385                 390                 395                 400 





Lys Gln Arg Gln Leu Phe Leu Ser Glu Asn Arg Arg Lys Glu Leu Leu 

                405                 410                 415     





Gln Arg Ile Ile Val Glu Leu Val Glu Phe Ile Ser Pro Lys Thr Pro 

            420                 425                 430         





Lys Pro Gly Glu Leu Gly Gly Arg Ile Ser Gly Ser Val Ala Trp Arg 

        435                 440                 445             





Val Ala Arg Gly Glu Met Gly Leu Gln Arg Lys Glu Thr Leu Phe Ile 

    450                 455                 460                 





Pro Cys Glu Asn Glu Lys Ile Ser Lys Gln Leu His Leu Cys Tyr Asn 

465                 470                 475                 480 





Ile Val Lys Asp Arg Tyr Val Arg Val Ser Asn Asn Asn Gln Thr Ile 

                485                 490                 495     





Ser Gly Trp Glu Asn Gly Val Trp Lys Met Glu Ser Ile Phe Arg Lys 

            500                 505                 510         





Val Glu Thr Asp Trp His Met Val Tyr Leu Ala Arg Lys Glu Gly Ser 

        515                 520                 525             





Ser Phe Ala Tyr Ile Ser Trp Lys Phe Glu Cys Gly Ser Val Gly Leu 

    530                 535                 540                 





Lys Val Asp Ser Ile Ser Ile Arg Thr Ser Ser Gln Thr Phe Gln Thr 

545                 550                 555                 560 





Gly Thr Val Glu Trp Lys Leu Arg Ser Asp Thr Ala Gln Val Glu Leu 

                565                 570                 575     





Thr Gly Asp Asn Ser Leu His Ser Tyr Ala Asp Phe Ser Gly Ala Thr 

            580                 585                 590         





Glu Val Ile Leu Glu Ala Glu Leu Ser Arg Gly Asp Gly Asp Val Ala 

        595                 600                 605             





Trp Gln His Thr Gln Leu Phe Arg Gln Ser Leu Asn Asp His Glu Glu 

    610                 615                 620                 





Asn Cys Leu Glu Ile Ile Ile Lys Phe Ser Asp Leu 

625                 630                 635     





<210>  180

<211>  2539

<212>  DNA

<213>  Homo sapiens



<400>  180

gctttcccac gcacgcgtcc cgttcgactc tctttccgcc ggttgacttt aagccgcgtc       60



accttggctg aggtcagacc gtgggaggcg gctgggtagc tgtttgcgtg agcagagacg      120



cccctctcgg aacctcagtg actcgccgat aatcgaggac ctgccaataa cgcgatgaga      180



aaccctaatg atgaaaaata tagatccatc cggattggaa acacagcctt ttctactaga      240



ctcttgcctg tcagaggagc tgttgaatgt ttatttgaaa tgggctttga agagggagaa      300



acacatctca tctttcctaa aaaagcttca gtggagcagc tgcaaaaaat tcgtgacctg      360



attgccatag agagaagtag cagactggat ggctcaaata agagccacaa agtaaagtca      420



tctcagcaac ctgcagccag tacccagctt cctacaacac catcttcaaa tcccagtggg      480



ttaaaccagc acacaaggaa ccgtcaaggg cagtcatcag atccaccatc tgcttcaacg      540



gttgctgctg actcagccat tctagaagtt cttcagtcca acattcagca tgtgctggtc      600



tatgaaaatc ctgctcttca ggagaaagcg ttggcttgta ttccggtcca agaactaaaa      660



aggaaatcac aagaaaagtt atcgagagct agaaaattgg ataaaggtat caatataagt      720



gatgaggatt ttcttttgct ggagcttttg cactggttta aggaagaatt ttttcactgg      780



gtgaataacg ttttgtgcag caaatgtggt ggacagacta ggtctagaga tagatcatta      840



ctgcccagtg atgatgagct gaagtggggt gcaaaggaag tggaagatca ttactgtgat      900



gcctgccagt tcagcaatcg attcccaaga tataataacc ctgagaaact tttggaaaca      960



agatgtggac ggtgtggcga gtgggccaat tgttttacac tgtgctgccg agctgtaggg     1020



tttgaagctc gctatgtttg ggattacaca gaccatgtct ggacagaagt ctattctcct     1080



tctcagcagc ggtggctgca ctgtgatgca tgtgaagatg tctgtgacaa gccactcctt     1140



tatgaaatag gatggggcaa gaagctttcc tatgtcatag cattttcaaa agatgaggta     1200



gttgatgtca cttggcgata ttcctgcaaa catgaagagg tgattgccag aagaactaag     1260



gttaaagaag cattacttcg agacactatt aatgggctta ataagcagag gcaactgttt     1320



ttgtcagaaa acagaaggaa agaacttctc cagaggataa ttgtggagct tgttgaattt     1380



atatctccca aaacccctaa acctggagaa cttgggggaa gaatatctgg gtcagtggct     1440



tggagagtag cccgaggtga aatgggtcta cagagaaaag aaaccttgtt tattccctgt     1500



gaaaatgaga agatttctaa acagctccac ctttgttaca atattgtgaa agatcgttat     1560



gttcgagttt caaataacaa tcaaaccatt tctggatggg agaatggcgt gtggaaaatg     1620



gaatctatat tcagaaaagt tgaaacagac tggcacatgg tatatttggc ccgaaaggaa     1680



ggatcatctt ttgcttatat ttcctggaag tttgagtgtg ggtcagttgg cctaaaagta     1740



gatagcattt ctattagaac aagtagtcaa acttttcaga ctggaacagt agaatggaaa     1800



ttgcgatctg atacagcaca agtagaactg acaggcgata acagtcttca ctcctatgct     1860



gatttttctg gtgccactga agttattttg gaagcagaat taagcagagg agatggtgat     1920



gtcgcttggc aacacaccca gctgtttaga caaagcttaa atgaccatga agaaaattgt     1980



ttggagataa ttataaaatt cagtgacctt tgagaacctg aacattatag aaaagctggc     2040



aataatcaag gacttactga agtagtctgt tggttcagtg catgcttagt tggcagttac     2100



caccctgtgc tagcatattt cttttgctag ctatccatca tgtaaccctc atgaaaatta     2160



tctttatacg tggactataa taaaatattg aattaaaacc tttcttccat atgtgactat     2220



aatttggagt aaagtcttgt tgactcaata tgggatttta atctaaaact gtaagtatgg     2280



ttttaaaagt taaataatga tattcatgat taaatgctat tcatgattat gataaaatct     2340



tgggcttatg atagtaattt gacattttct gatcagccat tcatttcttc agaagtggtt     2400



aaattagagt ctcctaatat ttttaattaa tgtgaaagta cagtagctca taaattatat     2460



aatgcatgaa aatttatatg attataaata ttcaggcatt taagaaataa aatgaagtat     2520



tttgccttaa aaaaaaaaa                                                  2539





<210>  181

<211>  612

<212>  PRT

<213>  Homo sapiens



<400>  181



Met Arg Asn Pro Asn Asp Glu Lys Tyr Arg Ser Ile Arg Ile Gly Asn 

1               5                   10                  15      





Thr Ala Phe Ser Thr Arg Leu Leu Pro Val Arg Gly Ala Val Glu Cys 

            20                  25                  30          





Leu Phe Glu Met Gly Phe Glu Glu Gly Glu Thr His Leu Ile Phe Pro 

        35                  40                  45              





Lys Lys Ala Ser Val Glu Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala 

    50                  55                  60                  





Ile Glu Arg Ser Ser Arg Leu Asp Gly Ser Asn Lys Ser His Lys Val 

65                  70                  75                  80  





Lys Ser Ser Gln Gln Pro Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro 

                85                  90                  95      





Ser Ser Asn Pro Ser Gly Leu Asn Gln His Thr Arg Asn Arg Gln Gly 

            100                 105                 110         





Gln Ser Ser Asp Pro Pro Ser Ala Ser Thr Val Ala Ala Asp Ser Ala 

        115                 120                 125             





Ile Leu Glu Val Leu Gln Ser Asn Ile Gln His Val Leu Val Tyr Glu 

    130                 135                 140                 





Asn Pro Ala Leu Gln Glu Lys Ala Leu Ala Cys Ile Pro Val Gln Glu 

145                 150                 155                 160 





Leu Lys Arg Lys Ser Gln Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp 

                165                 170                 175     





Lys Gly Ile Asn Ile Ser Asp Glu Asp Phe Leu Leu Leu Glu Leu Leu 

            180                 185                 190         





His Trp Phe Lys Glu Glu Phe Phe His Trp Val Asn Asn Val Leu Cys 

        195                 200                 205             





Ser Lys Cys Gly Gly Gln Thr Arg Ser Arg Asp Arg Ser Leu Leu Pro 

    210                 215                 220                 





Ser Asp Asp Glu Leu Lys Trp Gly Ala Lys Glu Val Glu Asp His Tyr 

225                 230                 235                 240 





Cys Asp Ala Cys Gln Phe Ser Asn Arg Phe Pro Arg Tyr Asn Asn Pro 

                245                 250                 255     





Glu Lys Leu Leu Glu Thr Arg Cys Gly Arg Cys Gly Glu Trp Ala Asn 

            260                 265                 270         





Cys Phe Thr Leu Cys Cys Arg Ala Val Gly Phe Glu Ala Arg Tyr Val 

        275                 280                 285             





Trp Asp Tyr Thr Asp His Val Trp Thr Glu Val Tyr Ser Pro Ser Gln 

    290                 295                 300                 





Gln Arg Trp Leu His Cys Asp Ala Cys Glu Asp Val Cys Asp Lys Pro 

305                 310                 315                 320 





Leu Leu Tyr Glu Ile Gly Trp Gly Lys Lys Leu Ser Tyr Val Ile Ala 

                325                 330                 335     





Phe Ser Lys Asp Glu Val Val Asp Val Thr Trp Arg Tyr Ser Cys Lys 

            340                 345                 350         





His Glu Glu Val Ile Ala Arg Arg Thr Lys Val Lys Glu Ala Leu Leu 

        355                 360                 365             





Arg Asp Thr Ile Asn Gly Leu Asn Lys Gln Arg Gln Leu Phe Leu Ser 

    370                 375                 380                 





Glu Asn Arg Arg Lys Glu Leu Leu Gln Arg Ile Ile Val Glu Leu Val 

385                 390                 395                 400 





Glu Phe Ile Ser Pro Lys Thr Pro Lys Pro Gly Glu Leu Gly Gly Arg 

                405                 410                 415     





Ile Ser Gly Ser Val Ala Trp Arg Val Ala Arg Gly Glu Met Gly Leu 

            420                 425                 430         





Gln Arg Lys Glu Thr Leu Phe Ile Pro Cys Glu Asn Glu Lys Ile Ser 

        435                 440                 445             





Lys Gln Leu His Leu Cys Tyr Asn Ile Val Lys Asp Arg Tyr Val Arg 

    450                 455                 460                 





Val Ser Asn Asn Asn Gln Thr Ile Ser Gly Trp Glu Asn Gly Val Trp 

465                 470                 475                 480 





Lys Met Glu Ser Ile Phe Arg Lys Val Glu Thr Asp Trp His Met Val 

                485                 490                 495     





Tyr Leu Ala Arg Lys Glu Gly Ser Ser Phe Ala Tyr Ile Ser Trp Lys 

            500                 505                 510         





Phe Glu Cys Gly Ser Val Gly Leu Lys Val Asp Ser Ile Ser Ile Arg 

        515                 520                 525             





Thr Ser Ser Gln Thr Phe Gln Thr Gly Thr Val Glu Trp Lys Leu Arg 

    530                 535                 540                 





Ser Asp Thr Ala Gln Val Glu Leu Thr Gly Asp Asn Ser Leu His Ser 

545                 550                 555                 560 





Tyr Ala Asp Phe Ser Gly Ala Thr Glu Val Ile Leu Glu Ala Glu Leu 

                565                 570                 575     





Ser Arg Gly Asp Gly Asp Val Ala Trp Gln His Thr Gln Leu Phe Arg 

            580                 585                 590         





Gln Ser Leu Asn Asp His Glu Glu Asn Cys Leu Glu Ile Ile Ile Lys 

        595                 600                 605             





Phe Ser Asp Leu 

    610         





<210>  182

<211>  2421

<212>  DNA

<213>  Homo sapiens



<400>  182

ggaccccgcc cctgccggtg gctgcggtag ctgctgcgcg ctgaggcgcc tgctcagtgt       60



gggacgcgga gagcgagggg cggcggcggc gcccgctggc gctcaagcat ggcggcggcg      120



gcattgggca gctcctcagg ctcggcgtcc ccggccgtgg ctgagctctg ccagaacacc      180



ccggagacct ttttggaggc ctccaagctg ctgctcacct atgctgacaa catcctcaga      240



aaccctaatg atgaaaaata tagatccatc cggattggaa acacagcctt ttctactaga      300



ctcttgcctg tcagaggagc tgttgaatgt ttatttgaaa tgggctttga agagggagaa      360



acacatctca tctttcctaa aaaagcttca gtggagcagc tgcaaaaaat tcgtgacctg      420



attgccatag agagaagtag cagactggat ggctcaaata agagccacaa agtaaagtca      480



tctcagcaac ctgcagccag tacccagctt cctacaacac catcttcaaa tcccagtggg      540



ttaaaccagc acacaaggaa ccgtcaaggg cagtcatcag atccaccatc tgcttcaacg      600



gttgctgctg actcagccat tctagaagtt cttcagtcca acattcagca tgtgctggtc      660



tatgaaaatc ctgctcttca ggagaaagcg ttggcttgta ttccggtcca agaactaaaa      720



aggaaatcac aagaaaagtt atcgagagct agaaaattgg ataaaggtat caatataagt      780



gatgaggatt ttcttttgct ggagcttttg cactggttta aggaagaatt ttttcactgg      840



gtgaataacg ttttgtgcag caaatgtggt ggacagacta ggtctagaga tagatcatta      900



ctgcccagtg atgatgagct gaagtggggt gcaaaggaag tggaagatca ttactgtgat      960



gcctgccagt tcagcaatcg attcccaaga tataataacc ctgagaaact tttggaaaca     1020



agatgtggac ggtgtggcga gtgggccaat tgttttacac tgtgctgccg agctgtaggg     1080



tttgaagctc gctatgtttg ggattacaca gaccatgtct ggacagaagt ctattctcct     1140



tctcagcagc ggtggctgca ctgtgatgca tgtgaagatg tctgtgacaa gccactcctt     1200



tatgaaatag gatggggcaa gaagctttcc tatgtcatag cattttcaaa agatgaggta     1260



gttgatgtca cttggcgata ttcctgcaaa catgaagagg tgattgccag aagaactaag     1320



gttaaagaag cattacttcg agacactatt aatgggctta ataagcagag gcaactgttt     1380



ttgtcagaaa acagaaggaa agaacttctc cagaggataa ttgtggagct tgttgaattt     1440



atatctccca aaacccctaa acctggagaa cttgggggaa gaatatctgg gtcagtggct     1500



tggagagtag cccgaggtga aatgggtcta cagagaaaag aaaccttgtt tattccctgt     1560



gaaaatgaga agatttctaa acagctccac ctttgttaca atattgtgaa agatcgttat     1620



gttcgagttt caaataacaa tcaaaccatt tctggatggg agaatggcgt gtggaaaatg     1680



gaatctatat tcagaaaagt tgaaacagac tggcacatga taacagtctt cactcctatg     1740



ctgatttttc tggtgccact gaagttattt tggaagcaga attaagcaga ggagatggtg     1800



atgtcgcttg gcaacacacc cagctgttta gacaaagctt aaatgaccat gaagaaaatt     1860



gtttggagat aattataaaa ttcagtgacc tttgagaacc tgaacattat agaaaagctg     1920



gcaataatca aggacttact gaagtagtct gttggttcag tgcatgctta gttggcagtt     1980



accaccctgt gctagcatat ttcttttgct agctatccat catgtaaccc tcatgaaaat     2040



tatctttata cgtggactat aataaaatat tgaattaaaa cctttcttcc atatgtgact     2100



ataatttgga gtaaagtctt gttgactcaa tatgggattt taatctaaaa ctgtaagtat     2160



ggttttaaaa gttaaataat gatattcatg attaaatgct attcatgatt atgataaaat     2220



cttgggctta tgatagtaat ttgacatttt ctgatcagcc attcatttct tcagaagtgg     2280



ttaaattaga gtctcctaat atttttaatt aatgtgaaag tacagtagct cataaattat     2340



ataatgcatg aaaatttata tgattataaa tattcaggca tttaagaaat aaaatgaagt     2400



attttgcctt aaaaaaaaaa a                                               2421





<210>  183

<211>  558

<212>  PRT

<213>  Homo sapiens



<400>  183



Met Ala Ala Ala Ala Leu Gly Ser Ser Ser Gly Ser Ala Ser Pro Ala 

1               5                   10                  15      





Val Ala Glu Leu Cys Gln Asn Thr Pro Glu Thr Phe Leu Glu Ala Ser 

            20                  25                  30          





Lys Leu Leu Leu Thr Tyr Ala Asp Asn Ile Leu Arg Asn Pro Asn Asp 

        35                  40                  45              





Glu Lys Tyr Arg Ser Ile Arg Ile Gly Asn Thr Ala Phe Ser Thr Arg 

    50                  55                  60                  





Leu Leu Pro Val Arg Gly Ala Val Glu Cys Leu Phe Glu Met Gly Phe 

65                  70                  75                  80  





Glu Glu Gly Glu Thr His Leu Ile Phe Pro Lys Lys Ala Ser Val Glu 

                85                  90                  95      





Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg Ser Ser Arg 

            100                 105                 110         





Leu Asp Gly Ser Asn Lys Ser His Lys Val Lys Ser Ser Gln Gln Pro 

        115                 120                 125             





Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn Pro Ser Gly 

    130                 135                 140                 





Leu Asn Gln His Thr Arg Asn Arg Gln Gly Gln Ser Ser Asp Pro Pro 

145                 150                 155                 160 





Ser Ala Ser Thr Val Ala Ala Asp Ser Ala Ile Leu Glu Val Leu Gln 

                165                 170                 175     





Ser Asn Ile Gln His Val Leu Val Tyr Glu Asn Pro Ala Leu Gln Glu 

            180                 185                 190         





Lys Ala Leu Ala Cys Ile Pro Val Gln Glu Leu Lys Arg Lys Ser Gln 

        195                 200                 205             





Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp Lys Gly Ile Asn Ile Ser 

    210                 215                 220                 





Asp Glu Asp Phe Leu Leu Leu Glu Leu Leu His Trp Phe Lys Glu Glu 

225                 230                 235                 240 





Phe Phe His Trp Val Asn Asn Val Leu Cys Ser Lys Cys Gly Gly Gln 

                245                 250                 255     





Thr Arg Ser Arg Asp Arg Ser Leu Leu Pro Ser Asp Asp Glu Leu Lys 

            260                 265                 270         





Trp Gly Ala Lys Glu Val Glu Asp His Tyr Cys Asp Ala Cys Gln Phe 

        275                 280                 285             





Ser Asn Arg Phe Pro Arg Tyr Asn Asn Pro Glu Lys Leu Leu Glu Thr 

    290                 295                 300                 





Arg Cys Gly Arg Cys Gly Glu Trp Ala Asn Cys Phe Thr Leu Cys Cys 

305                 310                 315                 320 





Arg Ala Val Gly Phe Glu Ala Arg Tyr Val Trp Asp Tyr Thr Asp His 

                325                 330                 335     





Val Trp Thr Glu Val Tyr Ser Pro Ser Gln Gln Arg Trp Leu His Cys 

            340                 345                 350         





Asp Ala Cys Glu Asp Val Cys Asp Lys Pro Leu Leu Tyr Glu Ile Gly 

        355                 360                 365             





Trp Gly Lys Lys Leu Ser Tyr Val Ile Ala Phe Ser Lys Asp Glu Val 

    370                 375                 380                 





Val Asp Val Thr Trp Arg Tyr Ser Cys Lys His Glu Glu Val Ile Ala 

385                 390                 395                 400 





Arg Arg Thr Lys Val Lys Glu Ala Leu Leu Arg Asp Thr Ile Asn Gly 

                405                 410                 415     





Leu Asn Lys Gln Arg Gln Leu Phe Leu Ser Glu Asn Arg Arg Lys Glu 

            420                 425                 430         





Leu Leu Gln Arg Ile Ile Val Glu Leu Val Glu Phe Ile Ser Pro Lys 

        435                 440                 445             





Thr Pro Lys Pro Gly Glu Leu Gly Gly Arg Ile Ser Gly Ser Val Ala 

    450                 455                 460                 





Trp Arg Val Ala Arg Gly Glu Met Gly Leu Gln Arg Lys Glu Thr Leu 

465                 470                 475                 480 





Phe Ile Pro Cys Glu Asn Glu Lys Ile Ser Lys Gln Leu His Leu Cys 

                485                 490                 495     





Tyr Asn Ile Val Lys Asp Arg Tyr Val Arg Val Ser Asn Asn Asn Gln 

            500                 505                 510         





Thr Ile Ser Gly Trp Glu Asn Gly Val Trp Lys Met Glu Ser Ile Phe 

        515                 520                 525             





Arg Lys Val Glu Thr Asp Trp His Met Ile Thr Val Phe Thr Pro Met 

    530                 535                 540                 





Leu Ile Phe Leu Val Pro Leu Lys Leu Phe Trp Lys Gln Asn 

545                 550                 555             





<210>  184

<211>  2599

<212>  DNA

<213>  Homo sapiens



<400>  184

ggaccccgcc cctgccggtg gctgcggtag ctgctgcgcg ctgaggcgcc tgctcagtgt       60



gggacgcgga gagcgagggg cggcggcggc gcccgctggc gctcaagcat ggcggcggcg      120



gcattgggca gctcctcagg ctcggcgtcc ccggccgtgg ctgagctctg ccagaacacc      180



ccggagacct ttttggaggc ctccaagctg ctgctcacct atgctgacaa catcctcaga      240



aaccctaatg atgaaaaata tagatccatc cggattggaa acacagcctt ttctactaga      300



ctcttgcctg tcagaggagc tgttgaatgt ttatttgaaa tgggctttga agagggagaa      360



acacatctca tctttcctaa aaaagcttca gtggagcagc tgcaaaaaat tcgtgacctg      420



attgccatag agagaagtag cagactggat ggctcaaata agagccacaa agtaaagtca      480



tctcagcaac ctgcagccag tacccagctt cctacaacac catcttcaaa tcccagtggg      540



ttaaaccagc acacaaggaa ccgtcaaggg cagtcatcag atccaccatc tgcttcaacg      600



gttgctgctg actcagccat tctagaagtt cttcagtcca acattcagca tgtgctggtc      660



tatgaaaatc ctgctcttca ggagaaagcg ttggcttgta ttccggtcca agaactaaaa      720



aggaaatcac aagaaaagtt atcgagagct agaaaattgg ataaaggtat caatataagt      780



gatgaggatt ttcttttgct ggagcttttg cactggttta aggaagaatt ttttcactgg      840



gtgaataacg ttttgtgcag caaatgtggt ggacagacta ggtctagaga tagatcatta      900



ctgcccagtg atgatgagct gaagtggggt gcaaaggaag tggaagatca ttactgtgat      960



gcctgccagt tcagcaatcg attcccaaga tataataacc ctgagaaact tttggaaaca     1020



agatgtggac ggtgtggcga gtgggccaat tgttttacac tgtgctgccg agctgtaggg     1080



tttgaagctc gctatgtttg ggattacaca gaccatgtct ggacagaagt ctattctcct     1140



tctcagcagc ggtggctgca ctgtgatgca tgtgaagatg tctgtgacaa gccactcctt     1200



tatgaaatag gatggggcaa gaagctttcc tatgtcatag cattttcaaa agatgaggta     1260



gttgatgtca cttggcgata ttcctgcaaa catgaagagg tgattgccag aagaactaag     1320



gttaaagaag cattacttcg agacactatt aatgggctta ataagcagag gcaactgttt     1380



ttgtcagaaa acagaaggaa agaacttctc cagaggataa ttgtggagct tgttgaattt     1440



atatctccca aaacccctaa acctggagaa cttgggggaa gaatatctgg gtcagtggct     1500



tggagagtag cccgaggtga aatgggtcta cagagaaaag aaaccttgtt tattccctgt     1560



gaaaatgaga agatttctaa acagctccac ctttgttaca atattgtgaa agatcgttat     1620



gttcgagttt caaataacaa tcaaaccatt tctggatggg agaatggcgt gtggaaaatg     1680



gaatctatat tcagaaaagt tgaaacagac tggcacatgg tatatttggc ccgaaaggaa     1740



ggatcatctt ttgcttatat ttcctggaag tttgagtgtg ggtcagttgg cctaaaagta     1800



gatagcattt ctattagaac aagtagtcaa acttttcaga ctggaacagt agaatggaaa     1860



ttgcgatctg atacagcaca agtagaactg acaggcgata acagtcttca ctcctatgct     1920



gatttttctg gtgccactga agttattttg gaagcagaat taagcagagg agatggtgat     1980



gtcgcttggc aacacaccca gctgtttaga caaagcttaa atgaccatga agaaaattgt     2040



ttggagataa ttataaaatt cagtgacctt tgagaacctg aacattatag aaaagctggc     2100



aataatcaag gacttactga agtagtctgt tggttcagtg catgcttagt tggcagttac     2160



caccctgtgc tagcatattt cttttgctag ctatccatca tgtaaccctc atgaaaatta     2220



tctttatacg tggactataa taaaatattg aattaaaacc tttcttccat atgtgactat     2280



aatttggagt aaagtcttgt tgactcaata tgggatttta atctaaaact gtaagtatgg     2340



ttttaaaagt taaataatga tattcatgat taaatgctat tcatgattat gataaaatct     2400



tgggcttatg atagtaattt gacattttct gatcagccat tcatttcttc agaagtggtt     2460



aaattagagt ctcctaatat ttttaattaa tgtgaaagta cagtagctca taaattatat     2520



aatgcatgaa aatttatatg attataaata ttcaggcatt taagaaataa aatgaagtat     2580



tttgccttaa aaaaaaaaa                                                  2599





<210>  185

<211>  654

<212>  PRT

<213>  Homo sapiens



<400>  185



Met Ala Ala Ala Ala Leu Gly Ser Ser Ser Gly Ser Ala Ser Pro Ala 

1               5                   10                  15      





Val Ala Glu Leu Cys Gln Asn Thr Pro Glu Thr Phe Leu Glu Ala Ser 

            20                  25                  30          





Lys Leu Leu Leu Thr Tyr Ala Asp Asn Ile Leu Arg Asn Pro Asn Asp 

        35                  40                  45              





Glu Lys Tyr Arg Ser Ile Arg Ile Gly Asn Thr Ala Phe Ser Thr Arg 

    50                  55                  60                  





Leu Leu Pro Val Arg Gly Ala Val Glu Cys Leu Phe Glu Met Gly Phe 

65                  70                  75                  80  





Glu Glu Gly Glu Thr His Leu Ile Phe Pro Lys Lys Ala Ser Val Glu 

                85                  90                  95      





Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg Ser Ser Arg 

            100                 105                 110         





Leu Asp Gly Ser Asn Lys Ser His Lys Val Lys Ser Ser Gln Gln Pro 

        115                 120                 125             





Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn Pro Ser Gly 

    130                 135                 140                 





Leu Asn Gln His Thr Arg Asn Arg Gln Gly Gln Ser Ser Asp Pro Pro 

145                 150                 155                 160 





Ser Ala Ser Thr Val Ala Ala Asp Ser Ala Ile Leu Glu Val Leu Gln 

                165                 170                 175     





Ser Asn Ile Gln His Val Leu Val Tyr Glu Asn Pro Ala Leu Gln Glu 

            180                 185                 190         





Lys Ala Leu Ala Cys Ile Pro Val Gln Glu Leu Lys Arg Lys Ser Gln 

        195                 200                 205             





Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp Lys Gly Ile Asn Ile Ser 

    210                 215                 220                 





Asp Glu Asp Phe Leu Leu Leu Glu Leu Leu His Trp Phe Lys Glu Glu 

225                 230                 235                 240 





Phe Phe His Trp Val Asn Asn Val Leu Cys Ser Lys Cys Gly Gly Gln 

                245                 250                 255     





Thr Arg Ser Arg Asp Arg Ser Leu Leu Pro Ser Asp Asp Glu Leu Lys 

            260                 265                 270         





Trp Gly Ala Lys Glu Val Glu Asp His Tyr Cys Asp Ala Cys Gln Phe 

        275                 280                 285             





Ser Asn Arg Phe Pro Arg Tyr Asn Asn Pro Glu Lys Leu Leu Glu Thr 

    290                 295                 300                 





Arg Cys Gly Arg Cys Gly Glu Trp Ala Asn Cys Phe Thr Leu Cys Cys 

305                 310                 315                 320 





Arg Ala Val Gly Phe Glu Ala Arg Tyr Val Trp Asp Tyr Thr Asp His 

                325                 330                 335     





Val Trp Thr Glu Val Tyr Ser Pro Ser Gln Gln Arg Trp Leu His Cys 

            340                 345                 350         





Asp Ala Cys Glu Asp Val Cys Asp Lys Pro Leu Leu Tyr Glu Ile Gly 

        355                 360                 365             





Trp Gly Lys Lys Leu Ser Tyr Val Ile Ala Phe Ser Lys Asp Glu Val 

    370                 375                 380                 





Val Asp Val Thr Trp Arg Tyr Ser Cys Lys His Glu Glu Val Ile Ala 

385                 390                 395                 400 





Arg Arg Thr Lys Val Lys Glu Ala Leu Leu Arg Asp Thr Ile Asn Gly 

                405                 410                 415     





Leu Asn Lys Gln Arg Gln Leu Phe Leu Ser Glu Asn Arg Arg Lys Glu 

            420                 425                 430         





Leu Leu Gln Arg Ile Ile Val Glu Leu Val Glu Phe Ile Ser Pro Lys 

        435                 440                 445             





Thr Pro Lys Pro Gly Glu Leu Gly Gly Arg Ile Ser Gly Ser Val Ala 

    450                 455                 460                 





Trp Arg Val Ala Arg Gly Glu Met Gly Leu Gln Arg Lys Glu Thr Leu 

465                 470                 475                 480 





Phe Ile Pro Cys Glu Asn Glu Lys Ile Ser Lys Gln Leu His Leu Cys 

                485                 490                 495     





Tyr Asn Ile Val Lys Asp Arg Tyr Val Arg Val Ser Asn Asn Asn Gln 

            500                 505                 510         





Thr Ile Ser Gly Trp Glu Asn Gly Val Trp Lys Met Glu Ser Ile Phe 

        515                 520                 525             





Arg Lys Val Glu Thr Asp Trp His Met Val Tyr Leu Ala Arg Lys Glu 

    530                 535                 540                 





Gly Ser Ser Phe Ala Tyr Ile Ser Trp Lys Phe Glu Cys Gly Ser Val 

545                 550                 555                 560 





Gly Leu Lys Val Asp Ser Ile Ser Ile Arg Thr Ser Ser Gln Thr Phe 

                565                 570                 575     





Gln Thr Gly Thr Val Glu Trp Lys Leu Arg Ser Asp Thr Ala Gln Val 

            580                 585                 590         





Glu Leu Thr Gly Asp Asn Ser Leu His Ser Tyr Ala Asp Phe Ser Gly 

        595                 600                 605             





Ala Thr Glu Val Ile Leu Glu Ala Glu Leu Ser Arg Gly Asp Gly Asp 

    610                 615                 620                 





Val Ala Trp Gln His Thr Gln Leu Phe Arg Gln Ser Leu Asn Asp His 

625                 630                 635                 640 





Glu Glu Asn Cys Leu Glu Ile Ile Ile Lys Phe Ser Asp Leu 

                645                 650                 





<210>  186

<211>  1781

<212>  DNA

<213>  Homo sapiens



<400>  186

actcgggaag acttcagaga agtctcacaa aggactcggc tggctgcttt tctcagtgcc       60



gaagccgcgc catgctcgtt ctcagaagcg gcctgaccaa ggcgcttgcc tcacggacgc      120



tcgcgcctca ggtgtgttca tcttttgcta cgggccctag acaatacgat ggaacgttct      180



atgaatttcg tacttattac cttaaacctt caaatatgaa tgcgttcatg gaaaatctta      240



agaaaaacat tcatcttcgg acctcttact ctgaattggt tggattctgg agtgtagaat      300



ttggaggcag aacgaataaa gtgtttcata tttggaagta tgataatttt gctcatcgag      360



ctgaagttcg gaaagcctta gccaactgta aggaatggca agaacaatct atcattccaa      420



atttggctcg cattgataaa caagagacgg aaattactta cctgatacca tggtccaaat      480



tagaaaagcc tccaaaagaa ggagtctatg aactagctgt ttttcagatg aaacctggtg      540



ggccagctct gtggggtgat gcatttgaaa gagcaattaa tgcccatgtc aatttaggct      600



acacaaaagt agttggtgtt ttccacacag aatatggaga actcaacaga gttcatgttc      660



tttggtggaa tgagagtgca gatagtcgtg cagctgggag acataagtcc catgaggatc      720



ccagagttgt ggcggctgtt cgggaaagtg tcaactacct agtttctcag cagaatatgc      780



ttctgattcc tgcatcattt tcaccattga aatagttttc tactgaaata caaaacattt      840



cattaactgc tctaagatgt gtctgctaat ggtgcttaaa ttctcccaag aggttctcgc      900



ttttatttga aggaggtggt aagttaatta gttaatttgc tgtgcttctt gcatttttga      960



aagttacata ttctccactg ctttaagaaa taattcagtt cactttcacc ttggcatttc     1020



agtatctgtt acacattaga agtagttgtc actatttcat catcttggtt tttcatttgt     1080



tttagaatac ctcttctgta ttttgataac tcattgcttt atagcatttt cttttactca     1140



aataaggatt ttacatttcc ttgcctgaca gtatttttga attatttata taaaatatct     1200



atcttttcat catgtctata gttcctgaga ttttaaaaaa atttgcttag taaaggttat     1260



tttgtgatat aaaatgggat ttataaaaat attagattgt ttatttcttt actgtggaaa     1320



agtagaatgt catctgtatt aattattgct tttacattca ttgattatta gtcattctaa     1380



cttggaaaat aatgcaattg ggtcacagtg ttaaaaatct agaaaagact tgttggttta     1440



tatgctgaaa ttgttcattt ataattaatt ttactaattt ctccttagtt tggatcacta     1500



acagagatct tgggacattt atttgtttta aagaaatatt tatggttatg gaaacgcttg     1560



ccctaataaa aatcctgcat attcattgtt tttttaaatt cacattttat acttatatga     1620



tctctaaagc tcttgctatg ttgctataag acagtaatat agtgataatt taccaacttt     1680



attgaaaatg ttgttacatc aataaaatag catgctggga acctgagaag gaaggtttct     1740



ttagtactgc caaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         1781





<210>  187

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  187



Met Leu Val Leu Arg Ser Gly Leu Thr Lys Ala Leu Ala Ser Arg Thr 

1               5                   10                  15      





Leu Ala Pro Gln Val Cys Ser Ser Phe Ala Thr Gly Pro Arg Gln Tyr 

            20                  25                  30          





Asp Gly Thr Phe Tyr Glu Phe Arg Thr Tyr Tyr Leu Lys Pro Ser Asn 

        35                  40                  45              





Met Asn Ala Phe Met Glu Asn Leu Lys Lys Asn Ile His Leu Arg Thr 

    50                  55                  60                  





Ser Tyr Ser Glu Leu Val Gly Phe Trp Ser Val Glu Phe Gly Gly Arg 

65                  70                  75                  80  





Thr Asn Lys Val Phe His Ile Trp Lys Tyr Asp Asn Phe Ala His Arg 

                85                  90                  95      





Ala Glu Val Arg Lys Ala Leu Ala Asn Cys Lys Glu Trp Gln Glu Gln 

            100                 105                 110         





Ser Ile Ile Pro Asn Leu Ala Arg Ile Asp Lys Gln Glu Thr Glu Ile 

        115                 120                 125             





Thr Tyr Leu Ile Pro Trp Ser Lys Leu Glu Lys Pro Pro Lys Glu Gly 

    130                 135                 140                 





Val Tyr Glu Leu Ala Val Phe Gln Met Lys Pro Gly Gly Pro Ala Leu 

145                 150                 155                 160 





Trp Gly Asp Ala Phe Glu Arg Ala Ile Asn Ala His Val Asn Leu Gly 

                165                 170                 175     





Tyr Thr Lys Val Val Gly Val Phe His Thr Glu Tyr Gly Glu Leu Asn 

            180                 185                 190         





Arg Val His Val Leu Trp Trp Asn Glu Ser Ala Asp Ser Arg Ala Ala 

        195                 200                 205             





Gly Arg His Lys Ser His Glu Asp Pro Arg Val Val Ala Ala Val Arg 

    210                 215                 220                 





Glu Ser Val Asn Tyr Leu Val Ser Gln Gln Asn Met Leu Leu Ile Pro 

225                 230                 235                 240 





Ala Ser Phe Ser Pro Leu Lys 

                245         





<210>  188

<211>  4903

<212>  DNA

<213>  Homo sapiens



<400>  188

ctgctctcgc aactcaagat ggcggacgag agtgagacag cagtgaagcc gccggcacct       60



ccgctgccgc agatgatgga agggaacggg aacggccatg agcactgcag cgattgcgag      120



aatgaggagg acaacagcta caaccggggt ggtttgagtc cagccaatga cactggagcc      180



aaaaagaaga aaaagaaaca aaaaaagaag aaagaaaaag gcagtgagac agattcagcc      240



caggatcagc ctgtgaagat gaactctttg ccagcagaga ggatccagga aatacagaag      300



gccattgagc tgttctcagt gggtcaggga cctgccaaaa ccatggagga ggctagcaag      360



cgaagctacc agttctggga tacgcagccc gtccccaagc tgggcgaagt ggtgaacacc      420



catggccccg tggagcctga caaggacaat atccgccagg agccctacac cctgccccag      480



ggcttcacct gggatgcttt ggacttgggc gatcgtggtg tgctaaaaga actgtacacc      540



ctcctgaatg agaactatgt ggaagatgat gacaacatgt tccgatttga ttattccccg      600



gagtttcttt tgtgggctct ccggccaccc ggctggctcc cccagtggca ctgtggggtt      660



cgagtggtct caagtcggaa attggttggg ttcattagcg ccatcccagc aaacatccat      720



atctatgaca cagagaagaa gatggtagag atcaacttcc tgtgtgtcca caagaagctg      780



cgttccaaga gggttgctcc agttctgatc cgagagatca ccaggcgggt tcacctggag      840



ggcatcttcc aagcagttta cactgccggg gtggtactac caaagcccgt tggcacctgc      900



aggtattggc atcggtccct aaacccacgg aagctgattg aagtgaagtt ctcccacctg      960



agcagaaata tgaccatgca gcgcaccatg aagctctacc gactgccaga gactcccaag     1020



acagctgggc tgcgaccaat ggaaacaaag gacattccag tagtgcacca gctcctcacc     1080



aggtacttga agcaatttca ccttacgccc gtcatgagcc aggaggaggt ggagcactgg     1140



ttctaccccc aggagaatat catcgacact ttcgtggtgg agaacgcaaa cggagaggtg     1200



acagatttcc tgagctttta tacgctgccc tccaccatca tgaaccatcc aacccacaag     1260



agtctcaaag ctgcttattc tttctacaac gttcacaccc agacccctct tctagacctc     1320



atgagcgacg cccttgtcct cgccaaaatg aaagggtttg atgtgttcaa tgcactggat     1380



ctcatggaga acaaaacctt cctggagaag ctcaagtttg gcatagggga cggcaacctg     1440



cagtattacc tttacaattg gaaatgcccc agcatggggg cagagaaggt tggactggtg     1500



ctacaataac cagtcaccag tgcgattctg gataaagcca ctgaaaattc gaaccaggaa     1560



atggaacccc accactgttg gtccaatttt cacacacgtg agaatccctg gcaaagggag     1620



cagaactgaa ccggctttac caaaccgcca gcgaacttga caattgtatt gcgatggcgt     1680



gggctgcgtg acgtcacctc cggtcgtgtc tctggtctcc gtgttttcca gttaattaca     1740



tcctcatgca gccgtgatca agggaatgta actgctgaaa actagctcgt gattggcata     1800



taatggagtt aacgggtgaa taataaaagt atatatatat attatatata tataaatatt     1860



ttaaatatct ttcatgttcc aaatgtacaa ggatgtttgg tctttaatga aaagctgaat     1920



ctagatcatt cctcagaatg aggacccgag gacagtggca gacagacgcg ttggcacagt     1980



tcatggtttc ctccagagga gacattggct tatcatgggg aaaaagagga tctggagaac     2040



ctcatccagc tccccttctg aatcagctgg gatgactggc tttgagaagg aagggaagat     2100



ggaacaggct cagatctcat gggatagcac gtggagctct tggctggggc tgaccctggg     2160



cagggacttt cctgcagggc cagacctgcc tgcattctga gacaaagcaa tggacggtcc     2220



gcagaagcag acctcattga ttgagtcctt tcttccatcc ccttggcctg ctccctgtag     2280



gaagtcatcc tgccaactga tttaaaaggg ctctttagcc agttgttgcc aaccttatag     2340



ggatgagtcc cctgtgagat tttgcttttc cactgcctgg gatgatgcag tttgaagagg     2400



cccttggacc tccttgtaac atcagggacc tttggagacc attatcagtg taagccctgc     2460



ttagctcatc ttagagcaaa gagccagcac cctgatgtcc ctggggtggc taggcaggag     2520



tggcgtgggg ccaataccca gaccccttca gccaccagcc cctggcctgt gccttccaac     2580



ccattagcca tttcttgttg tgcccctttc caagatacag cctgcaagtg gtagcaagaa     2640



gtgattagag gcagatctgg acttggcaac agaagtggtt tcccatctcc attgtctgag     2700



tctgattttc gctgatgctg ttttgtggat ttttgtggta gtgatggttg tcagtgctgc     2760



cagtttccca aaacgtaatc aagcctctgg tcacatggct gtcgatgtag gcattctgga     2820



gtggtgttca gccaagtgac cgggcaaaat tgggctgtga aattgtactt ccaggcttgg     2880



atgtaatttt tgctctagag agaagcaagt ggtgggaagg aggtagcatg acgtgtggtg     2940



tgcgggtttc cttgctgccg tcacctctcc gctcatacag gaatgaagcc ttagccagga     3000



ggccaggctc agccctgtgc cactcaccga agccactttc tacaggccag caggggcttg     3060



ttgcaggctg tgggttttgg tgtggtttgt cagaggctaa ttctgcagag tttccaaaac     3120



cagaagacat cgtatgcttg ggatgggggc cgtgccaccc gtgggaatgc tgcccgctct     3180



gcagactgct gctagagcca gcaactccac taaggtggat tttcatcagg ggcctgcagg     3240



gccctccctt ttcccattgt tcctgcgctg caaattgcag gccccagcaa tcgtgactga     3300



cgtttgctcc ttgactccaa gaaactgaga ccaaagaagc tgctgttctt agcaagatgc     3360



gcactgcatt ccacaggtgg gaggagtcgg agaggcaggg gcttgctttg cagccccaca     3420



gacaacagtt gcacagtgcc tcaagcccca gagtggctca ccctgtccag acctttgagg     3480



atatcaaagg acaaagtgcc caagtctttc ctaccttggg ggaacctgga acttggaaag     3540



gctccctgtc ctagtcttga tctgttctgg gccaggtccc agcttgagct gcctctgaga     3600



tttgggctgt gcggatctct ggagtgagct ctgtttcggt tgacccaggt catggaatgg     3660



aaacggtgag gccccagtgg ctgttctgga agaaacagat ctcctggcaa aggccccagc     3720



atctccctca ctgaaaccag gtggccggct cctcggactc tgctttatgt tgcggtgaga     3780



actctgccca ggtgtgcagg gtttggcttg tgggctgctt gctgctcatc tgatttttgt     3840



cccagtagtc cctgcgttct tcattcaacc ccttctggga cttcagctca gagagcacca     3900



tcccgggggt cagggcctcc ccacaggagc cctgcagtgt ggtagcgcca tggctgtctc     3960



aaaccaagca aaggaaggac cctgaggcct tcacgctaac catcctcgag caactgctgt     4020



tggaaggcct ccctgggcct ggcccccacc ctctgccacc cagtcctccc agctgccatg     4080



tttcaaagac gacctttacc tcctgccttt ggattgactc tgcatttgac cacggactcc     4140



agtctgtgtg tagggagaga gctgagtagg aggcctccac tccggatcga ggcctgtata     4200



gggctcgttt ccccacacat gcctatttct gaagaggctt ctgtcttatt tgaaggccag     4260



cccacaccca gctactttaa caccaggttt atggaaaatg tcaggccttc cccacaactc     4320



ctgtctaact gctgtcgccc ccctacttgc tggctctcag aagcctaggg gagtccctgt     4380



ggtcctgaat tctttcccca aagacgacca gcatttaacc aacctaaggg cccaaaggcc     4440



ttggacaact gcatggagct gcactctagg agaaggaggg gaaccagatg ttagatcagg     4500



ggagggagca ggagtgtccc tcccgtcagt gcctacccac ctgtgaggca gccttctgat     4560



ggcctggccc accttcccca gaaccagggg aggcctgagg cttcagtttt actctgctgc     4620



aaaatgaagg cgggcctgca agccgactac acctacggag gctgttgagg acaatttcat     4680



tccattaaat taaaaaatac tgactggctg gcaggcaggt gccatgtctg ggaacaggga     4740



cgggggagct tcaccttttt gtcttggctt ttctttgggc tgtggggggg catccatttc     4800



cagggtcggg gaggaaatac caaatgcatt gttgttctgc tcaatacatc tcacttgttt     4860



ctaataaaga aagcagctga acaaaaaaaa aaaaaaaaaa aaa                       4903





<210>  189

<211>  496

<212>  PRT

<213>  Homo sapiens



<400>  189



Met Ala Asp Glu Ser Glu Thr Ala Val Lys Pro Pro Ala Pro Pro Leu 

1               5                   10                  15      





Pro Gln Met Met Glu Gly Asn Gly Asn Gly His Glu His Cys Ser Asp 

            20                  25                  30          





Cys Glu Asn Glu Glu Asp Asn Ser Tyr Asn Arg Gly Gly Leu Ser Pro 

        35                  40                  45              





Ala Asn Asp Thr Gly Ala Lys Lys Lys Lys Lys Lys Gln Lys Lys Lys 

    50                  55                  60                  





Lys Glu Lys Gly Ser Glu Thr Asp Ser Ala Gln Asp Gln Pro Val Lys 

65                  70                  75                  80  





Met Asn Ser Leu Pro Ala Glu Arg Ile Gln Glu Ile Gln Lys Ala Ile 

                85                  90                  95      





Glu Leu Phe Ser Val Gly Gln Gly Pro Ala Lys Thr Met Glu Glu Ala 

            100                 105                 110         





Ser Lys Arg Ser Tyr Gln Phe Trp Asp Thr Gln Pro Val Pro Lys Leu 

        115                 120                 125             





Gly Glu Val Val Asn Thr His Gly Pro Val Glu Pro Asp Lys Asp Asn 

    130                 135                 140                 





Ile Arg Gln Glu Pro Tyr Thr Leu Pro Gln Gly Phe Thr Trp Asp Ala 

145                 150                 155                 160 





Leu Asp Leu Gly Asp Arg Gly Val Leu Lys Glu Leu Tyr Thr Leu Leu 

                165                 170                 175     





Asn Glu Asn Tyr Val Glu Asp Asp Asp Asn Met Phe Arg Phe Asp Tyr 

            180                 185                 190         





Ser Pro Glu Phe Leu Leu Trp Ala Leu Arg Pro Pro Gly Trp Leu Pro 

        195                 200                 205             





Gln Trp His Cys Gly Val Arg Val Val Ser Ser Arg Lys Leu Val Gly 

    210                 215                 220                 





Phe Ile Ser Ala Ile Pro Ala Asn Ile His Ile Tyr Asp Thr Glu Lys 

225                 230                 235                 240 





Lys Met Val Glu Ile Asn Phe Leu Cys Val His Lys Lys Leu Arg Ser 

                245                 250                 255     





Lys Arg Val Ala Pro Val Leu Ile Arg Glu Ile Thr Arg Arg Val His 

            260                 265                 270         





Leu Glu Gly Ile Phe Gln Ala Val Tyr Thr Ala Gly Val Val Leu Pro 

        275                 280                 285             





Lys Pro Val Gly Thr Cys Arg Tyr Trp His Arg Ser Leu Asn Pro Arg 

    290                 295                 300                 





Lys Leu Ile Glu Val Lys Phe Ser His Leu Ser Arg Asn Met Thr Met 

305                 310                 315                 320 





Gln Arg Thr Met Lys Leu Tyr Arg Leu Pro Glu Thr Pro Lys Thr Ala 

                325                 330                 335     





Gly Leu Arg Pro Met Glu Thr Lys Asp Ile Pro Val Val His Gln Leu 

            340                 345                 350         





Leu Thr Arg Tyr Leu Lys Gln Phe His Leu Thr Pro Val Met Ser Gln 

        355                 360                 365             





Glu Glu Val Glu His Trp Phe Tyr Pro Gln Glu Asn Ile Ile Asp Thr 

    370                 375                 380                 





Phe Val Val Glu Asn Ala Asn Gly Glu Val Thr Asp Phe Leu Ser Phe 

385                 390                 395                 400 





Tyr Thr Leu Pro Ser Thr Ile Met Asn His Pro Thr His Lys Ser Leu 

                405                 410                 415     





Lys Ala Ala Tyr Ser Phe Tyr Asn Val His Thr Gln Thr Pro Leu Leu 

            420                 425                 430         





Asp Leu Met Ser Asp Ala Leu Val Leu Ala Lys Met Lys Gly Phe Asp 

        435                 440                 445             





Val Phe Asn Ala Leu Asp Leu Met Glu Asn Lys Thr Phe Leu Glu Lys 

    450                 455                 460                 





Leu Lys Phe Gly Ile Gly Asp Gly Asn Leu Gln Tyr Tyr Leu Tyr Asn 

465                 470                 475                 480 





Trp Lys Cys Pro Ser Met Gly Ala Glu Lys Val Gly Leu Val Leu Gln 

                485                 490                 495     





<210>  190

<211>  3158

<212>  DNA

<213>  Homo sapiens



<400>  190

gttttaggga cagactgctt ccgggtcgaa gggcttgctt ccggagagcg ggaaggctaa       60



aacgcggtag ctaaactgca gccaactttg gttgtgtgtg gaaaaggctt tagccatgga      120



caggagtggc tttggagaga tatcatcccc tgtaatccgg gaggcagagg tgacacggac      180



tgcacggaaa cagagtgctc agaaaagagt tttacttcag gcatctcaag atgaaaattt      240



tggtaatact acaccaagaa accaggttat ccctcgaact cctagctcat ttcgacagcc      300



ttttacccca acaagccgaa gcttactaag gcagccagat atttcctgca ttcttggaac      360



aggagggaag tcgccccgac ttacgcagtc ttcagggttc tttggaaatc tctccatggt      420



tactaatctg gatgacagta actgggcagc tgcattttca tcacagcgtt ccgggctgtt      480



cacaaacaca gagccccaca gtataacaga agatgtaact atcagtgctg ttatgttacg      540



tgaggatgat cctggagaag ctgcatccat gagtatgttt tctgatttcc tgcagtcttt      600



tctgaagcac tcttcgagta cagtttttga tcttgtggaa gagtatgaaa acatctgtgg      660



tagtcaggtg aatatactga gtaaaatagt gagtcgagca acacctggac ttcaaaaatt      720



ttcaaaaaca gccagtatgc tctggcttct tcaacaggag atggtcacat ggaggctgct      780



ggcttctttg tatagagaca gaatacagtc tgcattagaa gaggaaagtg tattcgcagt      840



tactgctgtt aatgccagtg aaaaaacagt tgtggaagcg ttatttcaga gggattcact      900



tgttcgacaa agtcagctgg tggtagattg gttagagagt attgccaaag atgaaattgg      960



agaattttct gataatattg agttttatgc aaaatcagta tattgggaaa atactctgca     1020



taccttaaaa caacggcagc tgacttctta cgttggaagt gttcgtccgc ttgtcactga     1080



attggaccct gatgctccca taagacagaa aatgcccctt gatgatctgg atagagaaga     1140



tgaagttaga ttactcaaat atctctttac tctaatccgt gctggaatga cagaagaggc     1200



acaacgactc tgtaaacgct gtggtcaagc atggagagct gcaacacttg aaggctggaa     1260



actgtaccat gaccctaatg ttaatggagg aacagaatta gaacctgttg aagggaatcc     1320



atatagacgc atttggaaaa taagttgctg gagaatggca gaagatgagc tttttaatag     1380



atacgagaga gcaatttatg cagctttaag tgggaatctt aagcagctgc ttcctgtctg     1440



tgacacctgg gaagacacag tttgggccta cttccgggtg atggtggaca gtctggtaga     1500



acaggagatc cagacatcag tagcaactct ggatgaaact gaagaactcc ctagagaata     1560



tctgggagca aactggacgt tagaaaaggt ttttgaggaa cttcaagcta ctgacaaaaa     1620



gagagttctg gaagagaatc aagaacatta tcatatagtt caaaagtttc ttatcctggg     1680



agacattgat ggtttgatgg atgagtttag caaatggctt tccaaaagca gaaacaatct     1740



acctggacac ctgcttcgct ttatgactca ccttattttg tttttccgta ctctgggact     1800



acagaccaag gaggaagttt ctattgaagt tttaaagaca tacatacagc ttttaataag     1860



agagaaacat acaaatctta tagcatttta tacctgtcat ttgcctcaag acctagctgt     1920



tgcccagtat gcattatttt tggaaagtgt tacagaattt gaacagcgcc accattgcct     1980



ggagttggct aaagaagcag atttggatgt tgcaacaata acaaaaactg tagttgagaa     2040



tattcgaaag aaagataatg gtgaatttag tcatcatgac ctggccccag ccctagatac     2100



tggcactact gaggaggatc gtttaaaaat tgatgtaatt gactggttgg tatttgaccc     2160



agcgcagagg gcagaagcac tgaaacaagg caatgcaatt atgagaaaat tcttggcatc     2220



aaaaaagcac gaagctgcaa aagaagtatt tgtgaaaatt cctcaggatt ctatagcaga     2280



aatctataat cagtgcgagg aacaaggaat ggaaagtcca cttcctgctg aagatgataa     2340



tgctatccga gaacatttgt gcatcagagc ttatttggaa gcccatgaaa cctttaatga     2400



gtggtttaag catatgaatt cagttccaca aaaacctgct ttgatacctc aaccaacttt     2460



tactgagaaa gtggctcatg aacacaaaga aaagaaatat gaaatggatt ttggtatttg     2520



gaaagggcat ttggatgccc taactgctga tgtgaaggag aaaatgtata acgtcttgtt     2580



gtttgttgat ggagggtgga tggtggatgt tagagaggat gccaaagaag accatgaaag     2640



aacacatcaa atggtcttac tgagaaagct ttgtctgcca atgttgtgtt ttctgcttca     2700



tacgatattg cacagtactg gtcagtatca ggaatgccta cagttagcag atatggtatc     2760



ctctgagcgc cacaaactgt acctggtatt ttctaaggaa gagctaagga agttgctgca     2820



gaagctcaga gagtcctctc taatgctcct agaccaggga cttgacccat tagggtatga     2880



aattcagtta tagtttaatc tttgtaatct cactaatttt catgataaat gaagttttta     2940



ataaaatata cttgttatta gtaatttttt cttttgcatt accatgtaaa atttagacat     3000



ttgaattttg tacttttcag aatattatcg tgacactttc aacatgtagg gatatcagcg     3060



tttctctgtg tgcttgttaa taaaactata taaaaattaa aattttctgt ttttacaaat     3120



tccaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             3158





<210>  191

<211>  925

<212>  PRT

<213>  Homo sapiens



<400>  191



Met Asp Arg Ser Gly Phe Gly Glu Ile Ser Ser Pro Val Ile Arg Glu 

1               5                   10                  15      





Ala Glu Val Thr Arg Thr Ala Arg Lys Gln Ser Ala Gln Lys Arg Val 

            20                  25                  30          





Leu Leu Gln Ala Ser Gln Asp Glu Asn Phe Gly Asn Thr Thr Pro Arg 

        35                  40                  45              





Asn Gln Val Ile Pro Arg Thr Pro Ser Ser Phe Arg Gln Pro Phe Thr 

    50                  55                  60                  





Pro Thr Ser Arg Ser Leu Leu Arg Gln Pro Asp Ile Ser Cys Ile Leu 

65                  70                  75                  80  





Gly Thr Gly Gly Lys Ser Pro Arg Leu Thr Gln Ser Ser Gly Phe Phe 

                85                  90                  95      





Gly Asn Leu Ser Met Val Thr Asn Leu Asp Asp Ser Asn Trp Ala Ala 

            100                 105                 110         





Ala Phe Ser Ser Gln Arg Ser Gly Leu Phe Thr Asn Thr Glu Pro His 

        115                 120                 125             





Ser Ile Thr Glu Asp Val Thr Ile Ser Ala Val Met Leu Arg Glu Asp 

    130                 135                 140                 





Asp Pro Gly Glu Ala Ala Ser Met Ser Met Phe Ser Asp Phe Leu Gln 

145                 150                 155                 160 





Ser Phe Leu Lys His Ser Ser Ser Thr Val Phe Asp Leu Val Glu Glu 

                165                 170                 175     





Tyr Glu Asn Ile Cys Gly Ser Gln Val Asn Ile Leu Ser Lys Ile Val 

            180                 185                 190         





Ser Arg Ala Thr Pro Gly Leu Gln Lys Phe Ser Lys Thr Ala Ser Met 

        195                 200                 205             





Leu Trp Leu Leu Gln Gln Glu Met Val Thr Trp Arg Leu Leu Ala Ser 

    210                 215                 220                 





Leu Tyr Arg Asp Arg Ile Gln Ser Ala Leu Glu Glu Glu Ser Val Phe 

225                 230                 235                 240 





Ala Val Thr Ala Val Asn Ala Ser Glu Lys Thr Val Val Glu Ala Leu 

                245                 250                 255     





Phe Gln Arg Asp Ser Leu Val Arg Gln Ser Gln Leu Val Val Asp Trp 

            260                 265                 270         





Leu Glu Ser Ile Ala Lys Asp Glu Ile Gly Glu Phe Ser Asp Asn Ile 

        275                 280                 285             





Glu Phe Tyr Ala Lys Ser Val Tyr Trp Glu Asn Thr Leu His Thr Leu 

    290                 295                 300                 





Lys Gln Arg Gln Leu Thr Ser Tyr Val Gly Ser Val Arg Pro Leu Val 

305                 310                 315                 320 





Thr Glu Leu Asp Pro Asp Ala Pro Ile Arg Gln Lys Met Pro Leu Asp 

                325                 330                 335     





Asp Leu Asp Arg Glu Asp Glu Val Arg Leu Leu Lys Tyr Leu Phe Thr 

            340                 345                 350         





Leu Ile Arg Ala Gly Met Thr Glu Glu Ala Gln Arg Leu Cys Lys Arg 

        355                 360                 365             





Cys Gly Gln Ala Trp Arg Ala Ala Thr Leu Glu Gly Trp Lys Leu Tyr 

    370                 375                 380                 





His Asp Pro Asn Val Asn Gly Gly Thr Glu Leu Glu Pro Val Glu Gly 

385                 390                 395                 400 





Asn Pro Tyr Arg Arg Ile Trp Lys Ile Ser Cys Trp Arg Met Ala Glu 

                405                 410                 415     





Asp Glu Leu Phe Asn Arg Tyr Glu Arg Ala Ile Tyr Ala Ala Leu Ser 

            420                 425                 430         





Gly Asn Leu Lys Gln Leu Leu Pro Val Cys Asp Thr Trp Glu Asp Thr 

        435                 440                 445             





Val Trp Ala Tyr Phe Arg Val Met Val Asp Ser Leu Val Glu Gln Glu 

    450                 455                 460                 





Ile Gln Thr Ser Val Ala Thr Leu Asp Glu Thr Glu Glu Leu Pro Arg 

465                 470                 475                 480 





Glu Tyr Leu Gly Ala Asn Trp Thr Leu Glu Lys Val Phe Glu Glu Leu 

                485                 490                 495     





Gln Ala Thr Asp Lys Lys Arg Val Leu Glu Glu Asn Gln Glu His Tyr 

            500                 505                 510         





His Ile Val Gln Lys Phe Leu Ile Leu Gly Asp Ile Asp Gly Leu Met 

        515                 520                 525             





Asp Glu Phe Ser Lys Trp Leu Ser Lys Ser Arg Asn Asn Leu Pro Gly 

    530                 535                 540                 





His Leu Leu Arg Phe Met Thr His Leu Ile Leu Phe Phe Arg Thr Leu 

545                 550                 555                 560 





Gly Leu Gln Thr Lys Glu Glu Val Ser Ile Glu Val Leu Lys Thr Tyr 

                565                 570                 575     





Ile Gln Leu Leu Ile Arg Glu Lys His Thr Asn Leu Ile Ala Phe Tyr 

            580                 585                 590         





Thr Cys His Leu Pro Gln Asp Leu Ala Val Ala Gln Tyr Ala Leu Phe 

        595                 600                 605             





Leu Glu Ser Val Thr Glu Phe Glu Gln Arg His His Cys Leu Glu Leu 

    610                 615                 620                 





Ala Lys Glu Ala Asp Leu Asp Val Ala Thr Ile Thr Lys Thr Val Val 

625                 630                 635                 640 





Glu Asn Ile Arg Lys Lys Asp Asn Gly Glu Phe Ser His His Asp Leu 

                645                 650                 655     





Ala Pro Ala Leu Asp Thr Gly Thr Thr Glu Glu Asp Arg Leu Lys Ile 

            660                 665                 670         





Asp Val Ile Asp Trp Leu Val Phe Asp Pro Ala Gln Arg Ala Glu Ala 

        675                 680                 685             





Leu Lys Gln Gly Asn Ala Ile Met Arg Lys Phe Leu Ala Ser Lys Lys 

    690                 695                 700                 





His Glu Ala Ala Lys Glu Val Phe Val Lys Ile Pro Gln Asp Ser Ile 

705                 710                 715                 720 





Ala Glu Ile Tyr Asn Gln Cys Glu Glu Gln Gly Met Glu Ser Pro Leu 

                725                 730                 735     





Pro Ala Glu Asp Asp Asn Ala Ile Arg Glu His Leu Cys Ile Arg Ala 

            740                 745                 750         





Tyr Leu Glu Ala His Glu Thr Phe Asn Glu Trp Phe Lys His Met Asn 

        755                 760                 765             





Ser Val Pro Gln Lys Pro Ala Leu Ile Pro Gln Pro Thr Phe Thr Glu 

    770                 775                 780                 





Lys Val Ala His Glu His Lys Glu Lys Lys Tyr Glu Met Asp Phe Gly 

785                 790                 795                 800 





Ile Trp Lys Gly His Leu Asp Ala Leu Thr Ala Asp Val Lys Glu Lys 

                805                 810                 815     





Met Tyr Asn Val Leu Leu Phe Val Asp Gly Gly Trp Met Val Asp Val 

            820                 825                 830         





Arg Glu Asp Ala Lys Glu Asp His Glu Arg Thr His Gln Met Val Leu 

        835                 840                 845             





Leu Arg Lys Leu Cys Leu Pro Met Leu Cys Phe Leu Leu His Thr Ile 

    850                 855                 860                 





Leu His Ser Thr Gly Gln Tyr Gln Glu Cys Leu Gln Leu Ala Asp Met 

865                 870                 875                 880 





Val Ser Ser Glu Arg His Lys Leu Tyr Leu Val Phe Ser Lys Glu Glu 

                885                 890                 895     





Leu Arg Lys Leu Leu Gln Lys Leu Arg Glu Ser Ser Leu Met Leu Leu 

            900                 905                 910         





Asp Gln Gly Leu Asp Pro Leu Gly Tyr Glu Ile Gln Leu 

        915                 920                 925 





<210>  192

<211>  4170

<212>  DNA

<213>  Homo sapiens



<400>  192

ctcttccctt aggtgtttaa gttccgcgcg caggccaggc tgcaacctga cggccagatc       60



cctcgctgtc ctagtcgctg ctccttggag tcatgttccc agccgcccct tctccgcgga      120



ccccgggtac cgggtcccga aggggcccgc tggccggact cgggcccggc tccacgcccc      180



ggacggctag caggaagggt ctgcccctgg ggtctgcagt cagctcccca gtgctcttct      240



cgccggtcgg ccggcgtagc tcgctaagct cgcggggaac accaacacga atgttcccac      300



accactccat aactgagtct gtgaactatg atgtgaaaac gtttggatct tctcttcctg      360



ttaaagtcat ggaagcccta acattggctg aagtcgatga ccagctgacc attaacatag      420



atgaaggtgg atgggcttgt ctggtgtgca aagagaagct cattatttgg aagattgctc      480



tgtcacctat tactaagtta tccgtttgca aagaacttca gctgccacct agtgatttcc      540



actggagtgc cgacttagtg gctctttctt actcttctcc ctcaggtgaa gcacattcta      600



ctcaggctgt tgctgtcatg gttgccacca gagaaggatc tatccgctat tggccaagcc      660



ttgctggtga agatacctac acagaggctt ttgtagattc gggaggtgat aagacttaca      720



gtttcctaac agcagtgcag ggaggaagtt ttattttgtc ttcatcagga agccaactaa      780



ttcggttgat acctgagagc tcaggaaaga ttcatcagca tatcctgcct caggggcaag      840



gcatgctttc aggaattggt cgaaaagttt cttctctttt tggaatttta tctcctagta      900



gtgatctcac actttcaagt gttctctggg atagagagag atcaagcttt tatagcctga      960



cgagttcaaa catcagtaaa tgggaattag atgattcttc agaaaagcat gcatacagtt     1020



gggatataaa tagagccctg aaggaaaaca ttaccgatgc tatttgggga tctgaaagta     1080



actatgaagc tattaaagaa ggagtcaaca ttcgatattt ggacttgaag caaaactgtg     1140



atgggctggt gattttggca gcagcatggc actcagcaga caatccatgt ctcatctatt     1200



actctctgat aacaatagaa gataatggtt gccaaatgtc agatgcagtt actgtagaag     1260



tcactcaata taatccacct tttcagtctg aagacctgat tttgtgtcag ttgacggtcc     1320



caaacttttc aaaccagact gcctatctgt ataacgaaag tgctgtctat gtgtgctcca     1380



caggaactgg gaaattttct cttccccagg agaaaattgt ctttaatgca caaggagata     1440



gtgttttagg tgctggtgcc tgtggtggtg ttcctatcat tttttctaga aacagtggac     1500



tggtgtctat tacttcaagg gaaaatgtgt ctatattggc agaagacttg gaagggtctt     1560



tagcatcttc agttgctgga ccaaacagtg agagtatgat ttttgagacc actacaaaga     1620



atgaaactat agcccaggaa gataaaatca agttgctgaa agctgccttt ctgcaatact     1680



gcagaaaaga tttaggtcat gctcaaatgg tggttgatga gctcttttcc tctcactctg     1740



atttggattc tgattctgaa ctagacaggg cagttaccca aatcagtgta gacctgatgg     1800



atgactaccc agcatctgac ccacggtggg ctgagtctgt ccctgaggaa gcacctgggt     1860



tcagcaatac gtcactgatt atccttcacc agctagaaga caagatgaaa gctcactctt     1920



ttcttatgga ctttattcat caagttggct tatttggacg tctaggcagt tttccagtta     1980



gagggacacc gatggccact cgactgttgc tctgtgagca tgccgaaaag ctgtcagccg     2040



ccattgttct caagaaccac cactcccggc tttctgacct tgtcaacaca gccatattga     2100



ttgctttgaa caagagggag tatgaaatcc catccaacct gactcctgca gatgtctttt     2160



tcagggaggt atcccaagta gataccatct gtgagtgctt actggagcat gaggagcaag     2220



tcttgaggga tgcacctatg gattccattg aatgggctga agtggtgatc aatgtgaaca     2280



atattctcaa ggatatgctg caggctgcta gtcattatcg ccaaaataga aactctttgt     2340



atagaagaga agaatcacta gaaaaagaac ctgaatatgt tccatggacg gcaacaagtg     2400



gtcctggtgg catccgaacg gtaataatac gccagcatga gattgtcctg aaggtggctt     2460



atccacaggc agacagcaac ctccgaaaca tcgtgaccga gcagctggta gccctgatcg     2520



attgcttcct ggatggttat gtttctcagc ttaagtctgt ggataaatcc agtaatcggg     2580



aaagatatga caatctggag atggaatacc tacagaaaag atcagatctc ttatctcctc     2640



ttctttcact aggccagtac ctgtgggctg cttctctagc agagaaatac tgtgactttg     2700



atatattggt acaaatgtgt gagcagactg acaaccagag ccgactccag cgctacatga     2760



cccagtttgc tgatcagaat ttttcagact ttctcttccg ttggtatctg gagaaaggaa     2820



agcgaggcaa attattatct cagcccattt ctcagcatgg acagttggca aattttttgc     2880



aagctcatga acatctcagc tggttacatg aaattaatag ccaagaatta gaaaaggctc     2940



atgcaacact tctgggtttg gcaaatatgg aaactcgtta ctttgcaaag aagaaaaccc     3000



ttcttggctt gagtaaattg gctgcattag cttcagactt ttcagaggat atgctacaag     3060



aaaaaattga agaaatggct gagcaggagc gctttctact gcatcaggag accctacctg     3120



aacagctgct ggcggagaaa cagctaaatc tcagtgcgat gccagtattg actgcaccac     3180



aactcattgg tctatatatc tgtgaagaaa atagaagagc taatgaatat gatttcaaga     3240



aagctttgga cttgttggaa tatattgatg aggaagaaga tataaatata aatgatctaa     3300



aactggaaat cctttgcaaa gctcttcaga gagataactg gtccagttct gatggcaaag     3360



atgatccaat tgaagtatct aaagacagta tatttgtgaa gatcttacag aaacttttaa     3420



aagatggcat tcagctcagt gagtacttac cggaggtgaa agacctgcta caagcggatc     3480



agcttggaag cttaaagtcc aatccttact tcgagtttgt tttgaaagca aattatgaat     3540



attatgttca gggacaaata taactttttc taaaaatggc cattgtttat gaaatctgta     3600



taagtgtgtc cttatacaaa ttttaggcca taaacaagtg taagtttgta caatttcata     3660



acatgtatag ctgagttttt atactttata tgtaggaagc taatataaaa tagttatgta     3720



actgtgattt tggttttcag ttatgtgact tgttttttcc acctgaaatg tgtcagttgt     3780



tgttcctgta ctcggtgccc tttcttttta ctctcacgtg gtcccaggtt ctggagttct     3840



tgtcctggtt ctagctgctc acatgtacaa atcacttcta ggcctcagtt tctgcgacta     3900



tgaaaattac tagattgcac tagcttgtct ctaaaattgc tgtgactcca gatactttgc     3960



actgaagaga atctagggtg tttgatatct gtttcagtta gggctaatgg gaaatgtcta     4020



gtaagataaa tgtcaacttt tgctgactta ttatgagatg aaaaaccaaa ggagagtggg     4080



cctaactcat gtgagcttga taactgatga actcattggg agcattttaa acttttctac     4140



ataaataata aatgagcact aatgaaagta                                      4170





<210>  193

<211>  1156

<212>  PRT

<213>  Homo sapiens



<400>  193



Met Phe Pro Ala Ala Pro Ser Pro Arg Thr Pro Gly Thr Gly Ser Arg 

1               5                   10                  15      





Arg Gly Pro Leu Ala Gly Leu Gly Pro Gly Ser Thr Pro Arg Thr Ala 

            20                  25                  30          





Ser Arg Lys Gly Leu Pro Leu Gly Ser Ala Val Ser Ser Pro Val Leu 

        35                  40                  45              





Phe Ser Pro Val Gly Arg Arg Ser Ser Leu Ser Ser Arg Gly Thr Pro 

    50                  55                  60                  





Thr Arg Met Phe Pro His His Ser Ile Thr Glu Ser Val Asn Tyr Asp 

65                  70                  75                  80  





Val Lys Thr Phe Gly Ser Ser Leu Pro Val Lys Val Met Glu Ala Leu 

                85                  90                  95      





Thr Leu Ala Glu Val Asp Asp Gln Leu Thr Ile Asn Ile Asp Glu Gly 

            100                 105                 110         





Gly Trp Ala Cys Leu Val Cys Lys Glu Lys Leu Ile Ile Trp Lys Ile 

        115                 120                 125             





Ala Leu Ser Pro Ile Thr Lys Leu Ser Val Cys Lys Glu Leu Gln Leu 

    130                 135                 140                 





Pro Pro Ser Asp Phe His Trp Ser Ala Asp Leu Val Ala Leu Ser Tyr 

145                 150                 155                 160 





Ser Ser Pro Ser Gly Glu Ala His Ser Thr Gln Ala Val Ala Val Met 

                165                 170                 175     





Val Ala Thr Arg Glu Gly Ser Ile Arg Tyr Trp Pro Ser Leu Ala Gly 

            180                 185                 190         





Glu Asp Thr Tyr Thr Glu Ala Phe Val Asp Ser Gly Gly Asp Lys Thr 

        195                 200                 205             





Tyr Ser Phe Leu Thr Ala Val Gln Gly Gly Ser Phe Ile Leu Ser Ser 

    210                 215                 220                 





Ser Gly Ser Gln Leu Ile Arg Leu Ile Pro Glu Ser Ser Gly Lys Ile 

225                 230                 235                 240 





His Gln His Ile Leu Pro Gln Gly Gln Gly Met Leu Ser Gly Ile Gly 

                245                 250                 255     





Arg Lys Val Ser Ser Leu Phe Gly Ile Leu Ser Pro Ser Ser Asp Leu 

            260                 265                 270         





Thr Leu Ser Ser Val Leu Trp Asp Arg Glu Arg Ser Ser Phe Tyr Ser 

        275                 280                 285             





Leu Thr Ser Ser Asn Ile Ser Lys Trp Glu Leu Asp Asp Ser Ser Glu 

    290                 295                 300                 





Lys His Ala Tyr Ser Trp Asp Ile Asn Arg Ala Leu Lys Glu Asn Ile 

305                 310                 315                 320 





Thr Asp Ala Ile Trp Gly Ser Glu Ser Asn Tyr Glu Ala Ile Lys Glu 

                325                 330                 335     





Gly Val Asn Ile Arg Tyr Leu Asp Leu Lys Gln Asn Cys Asp Gly Leu 

            340                 345                 350         





Val Ile Leu Ala Ala Ala Trp His Ser Ala Asp Asn Pro Cys Leu Ile 

        355                 360                 365             





Tyr Tyr Ser Leu Ile Thr Ile Glu Asp Asn Gly Cys Gln Met Ser Asp 

    370                 375                 380                 





Ala Val Thr Val Glu Val Thr Gln Tyr Asn Pro Pro Phe Gln Ser Glu 

385                 390                 395                 400 





Asp Leu Ile Leu Cys Gln Leu Thr Val Pro Asn Phe Ser Asn Gln Thr 

                405                 410                 415     





Ala Tyr Leu Tyr Asn Glu Ser Ala Val Tyr Val Cys Ser Thr Gly Thr 

            420                 425                 430         





Gly Lys Phe Ser Leu Pro Gln Glu Lys Ile Val Phe Asn Ala Gln Gly 

        435                 440                 445             





Asp Ser Val Leu Gly Ala Gly Ala Cys Gly Gly Val Pro Ile Ile Phe 

    450                 455                 460                 





Ser Arg Asn Ser Gly Leu Val Ser Ile Thr Ser Arg Glu Asn Val Ser 

465                 470                 475                 480 





Ile Leu Ala Glu Asp Leu Glu Gly Ser Leu Ala Ser Ser Val Ala Gly 

                485                 490                 495     





Pro Asn Ser Glu Ser Met Ile Phe Glu Thr Thr Thr Lys Asn Glu Thr 

            500                 505                 510         





Ile Ala Gln Glu Asp Lys Ile Lys Leu Leu Lys Ala Ala Phe Leu Gln 

        515                 520                 525             





Tyr Cys Arg Lys Asp Leu Gly His Ala Gln Met Val Val Asp Glu Leu 

    530                 535                 540                 





Phe Ser Ser His Ser Asp Leu Asp Ser Asp Ser Glu Leu Asp Arg Ala 

545                 550                 555                 560 





Val Thr Gln Ile Ser Val Asp Leu Met Asp Asp Tyr Pro Ala Ser Asp 

                565                 570                 575     





Pro Arg Trp Ala Glu Ser Val Pro Glu Glu Ala Pro Gly Phe Ser Asn 

            580                 585                 590         





Thr Ser Leu Ile Ile Leu His Gln Leu Glu Asp Lys Met Lys Ala His 

        595                 600                 605             





Ser Phe Leu Met Asp Phe Ile His Gln Val Gly Leu Phe Gly Arg Leu 

    610                 615                 620                 





Gly Ser Phe Pro Val Arg Gly Thr Pro Met Ala Thr Arg Leu Leu Leu 

625                 630                 635                 640 





Cys Glu His Ala Glu Lys Leu Ser Ala Ala Ile Val Leu Lys Asn His 

                645                 650                 655     





His Ser Arg Leu Ser Asp Leu Val Asn Thr Ala Ile Leu Ile Ala Leu 

            660                 665                 670         





Asn Lys Arg Glu Tyr Glu Ile Pro Ser Asn Leu Thr Pro Ala Asp Val 

        675                 680                 685             





Phe Phe Arg Glu Val Ser Gln Val Asp Thr Ile Cys Glu Cys Leu Leu 

    690                 695                 700                 





Glu His Glu Glu Gln Val Leu Arg Asp Ala Pro Met Asp Ser Ile Glu 

705                 710                 715                 720 





Trp Ala Glu Val Val Ile Asn Val Asn Asn Ile Leu Lys Asp Met Leu 

                725                 730                 735     





Gln Ala Ala Ser His Tyr Arg Gln Asn Arg Asn Ser Leu Tyr Arg Arg 

            740                 745                 750         





Glu Glu Ser Leu Glu Lys Glu Pro Glu Tyr Val Pro Trp Thr Ala Thr 

        755                 760                 765             





Ser Gly Pro Gly Gly Ile Arg Thr Val Ile Ile Arg Gln His Glu Ile 

    770                 775                 780                 





Val Leu Lys Val Ala Tyr Pro Gln Ala Asp Ser Asn Leu Arg Asn Ile 

785                 790                 795                 800 





Val Thr Glu Gln Leu Val Ala Leu Ile Asp Cys Phe Leu Asp Gly Tyr 

                805                 810                 815     





Val Ser Gln Leu Lys Ser Val Asp Lys Ser Ser Asn Arg Glu Arg Tyr 

            820                 825                 830         





Asp Asn Leu Glu Met Glu Tyr Leu Gln Lys Arg Ser Asp Leu Leu Ser 

        835                 840                 845             





Pro Leu Leu Ser Leu Gly Gln Tyr Leu Trp Ala Ala Ser Leu Ala Glu 

    850                 855                 860                 





Lys Tyr Cys Asp Phe Asp Ile Leu Val Gln Met Cys Glu Gln Thr Asp 

865                 870                 875                 880 





Asn Gln Ser Arg Leu Gln Arg Tyr Met Thr Gln Phe Ala Asp Gln Asn 

                885                 890                 895     





Phe Ser Asp Phe Leu Phe Arg Trp Tyr Leu Glu Lys Gly Lys Arg Gly 

            900                 905                 910         





Lys Leu Leu Ser Gln Pro Ile Ser Gln His Gly Gln Leu Ala Asn Phe 

        915                 920                 925             





Leu Gln Ala His Glu His Leu Ser Trp Leu His Glu Ile Asn Ser Gln 

    930                 935                 940                 





Glu Leu Glu Lys Ala His Ala Thr Leu Leu Gly Leu Ala Asn Met Glu 

945                 950                 955                 960 





Thr Arg Tyr Phe Ala Lys Lys Lys Thr Leu Leu Gly Leu Ser Lys Leu 

                965                 970                 975     





Ala Ala Leu Ala Ser Asp Phe Ser Glu Asp Met Leu Gln Glu Lys Ile 

            980                 985                 990         





Glu Glu Met Ala Glu Gln Glu Arg  Phe Leu Leu His Gln  Glu Thr Leu 

        995                 1000                 1005             





Pro Glu  Gln Leu Leu Ala Glu  Lys Gln Leu Asn Leu  Ser Ala Met 

    1010                 1015                 1020             





Pro Val  Leu Thr Ala Pro Gln  Leu Ile Gly Leu Tyr  Ile Cys Glu 

    1025                 1030                 1035             





Glu Asn  Arg Arg Ala Asn Glu  Tyr Asp Phe Lys Lys  Ala Leu Asp 

    1040                 1045                 1050             





Leu Leu  Glu Tyr Ile Asp Glu  Glu Glu Asp Ile Asn  Ile Asn Asp 

    1055                 1060                 1065             





Leu Lys  Leu Glu Ile Leu Cys  Lys Ala Leu Gln Arg  Asp Asn Trp 

    1070                 1075                 1080             





Ser Ser  Ser Asp Gly Lys Asp  Asp Pro Ile Glu Val  Ser Lys Asp 

    1085                 1090                 1095             





Ser Ile  Phe Val Lys Ile Leu  Gln Lys Leu Leu Lys  Asp Gly Ile 

    1100                 1105                 1110             





Gln Leu  Ser Glu Tyr Leu Pro  Glu Val Lys Asp Leu  Leu Gln Ala 

    1115                 1120                 1125             





Asp Gln  Leu Gly Ser Leu Lys  Ser Asn Pro Tyr Phe  Glu Phe Val 

    1130                 1135                 1140             





Leu Lys  Ala Asn Tyr Glu Tyr  Tyr Val Gln Gly Gln  Ile 

    1145                 1150                 1155     





<210>  194

<211>  5687

<212>  DNA

<213>  Homo sapiens



<400>  194

ttccccgctg ccagcactca ccctctctcc gctcctgctc gcaacctcgc ggttcctggg       60



gtgcttgtgc ccactgtgtg gacagcgcgg gcggactttt gggccggggc cgggcggcgg      120



gggaggctct ctaaggcctc cgcctctgcc tctcccgccc ccttacccgc cccggagcgg      180



gaagcggcgg aggctccgcc atggcctcgg gagccggagg agtcggaggg ggcggtggcg      240



gcaagatccg gacgcggcgt tgccaccagg ggccaattaa gccttaccag caggggcgac      300



aacagcatca gggcattctt agcagggtta cagaatctgt taagaatatt gtgccagggt      360



ggctacaaag atacttcaac aagaatgaag atgtatgcag ctgttcaaca gacacaagcg      420



aggttccacg ctggccagaa aataaagagg accatctggt atatgccgat gaggagagct      480



ctaatattac tgatgggaga atcacacctg agccagcagt cagtaataca gaagaacctt      540



caacaactag tactgcttca aattatccag atgtgttaac aaggccttct cttcatcgga      600



gccatctgaa tttttccatg ttggaatccc ctgcattaca ctgtcagcca tctacatcct      660



cggcattccc aattggcagt tcgggatttt cccttgtaaa ggaaattaaa gattctacct      720



ctcagcatga tgatgataac atctcaacta ccagtggttt ttcttcaaga gcttctgata      780



aagatataac tgtttcaaag aacacttcat tgccacctct gtggtcccca gaagctgaac      840



gttctcactc actctcacag cacactgcca ccagctcaaa aaaaccagca ttcaacttgt      900



ctgcctttgg aacactttcc ccttcacttg ggaattcttc aatccttaaa accagtcagc      960



ttggagattc tcctttttat cctggaaaaa caacatacgg tggggcagca gctgctgtaa     1020



gacagtctaa actacgaaat acaccttatc aggcaccagt tagaagacaa atgaaagcta     1080



agcaactcag tgcacaatct tacggtgtga ccagttcaac agctcggcga atattgcagt     1140



ctttagagaa gatgtcaagc cctttagcgg atgcaaaaag aattccatcc attgtttctt     1200



ctcctctgaa ttctcctctt gataggagtg ggatagatat cacagatttt caggccaaaa     1260



gagaaaaggt ggattctcaa tatcctcctg ttcagagact tatgacccca aagccagttt     1320



ccatagcaac aaatcgaagt gtttatttta aaccatctct gactccttct ggtgaattca     1380



ggaagactaa tcaaagaata gataacaagt gcagtactgg atatgaaaaa aatatgacac     1440



ccggacaaaa tagagaacaa cgagaaagtg gcttttcata tccaaatttc agtttgcctg     1500



cagccaatgg tttatcttct ggagtaggtg gtggaggtgg caagatgaga cgagaaagaa     1560



cacgctttgt tgcttctaaa cctctggagg aggaggaaat ggaagttcca gtattaccga     1620



aaatctctct accgatcacc agttcttcac tgcctacctt taattttagt tcccctgaga     1680



tcacaacttc ctctccatca cccatcaatt cgtctcaagc attaacaaac aaggtacaaa     1740



tgacctctcc gagcagcact ggcagtccca tgtttaaatt ttcatctcca atcgtaaaat     1800



ctactgaggc aaatgtacta cctccatcat ctattggatt tacatttagt gtgcctgttg     1860



caaaaacagc agaactttct ggttctagta gtactttaga accaattata agtagttcag     1920



ctcatcatgt cactacagtg aacagtacaa attgtaagaa gacaccacct gaagattgtg     1980



agggtccttt tagacctgca gaaatcctga aagaaggaag tgttctagat attctgaaaa     2040



gccctggttt cgcatcgccg aagatagatt ctgttgctgc tcagcccacc gcaacaagcc     2100



cagtagttta tacaagacca gcaataagta gcttttcttc tagtggaatt gggtttgggg     2160



agagtttaaa agctgggtca tcatggcagt gtgatacatg tctactccag aacaaagtta     2220



cagacaacaa atgcatagcc tgtcaagcag caaaattgtc acccagagat actgctaaac     2280



agactggaat tgaaacacca aataaaagtg gcaaaacaac tctttctgca tcagggacag     2340



gctttggaga caaatttaaa ccagtgatag gcacttggga ttgtgatacc tgtttagtgc     2400



aaaataaacc tgaagcaata aaatgtgtag cctgtgaaac accgaaacct ggaacttgtg     2460



tgaagcgagc ccttacattg acagtggttt cggaaagtgc tgagactatg actgcttcat     2520



cttccagctg cactgtaacc actggtacct taggatttgg agataaattc aaaaggccca     2580



ttggatcttg ggagtgttca gtatgctgtg tttctaataa tgcagaagac aataagtgtg     2640



tgtcctgtat gtctgagaaa ccaggaagtt cagtacctgc ttcaagtagc agcactgtac     2700



ctgtctctct gccttctgga ggctctctag gattggaaaa gttcaagaaa cccgagggaa     2760



gctgggactg tgaattgtgc ctagtgcaga ataaggcaga ctctaccaaa tgtttggcat     2820



gtgaaagtgc aaagccaggc acaaaatctg ggtttaaagg ctttgacaca tcttcctcat     2880



cttcgaactc agcagcctcc tcatccttca aatttggtgt ctcatcatcc tcttctgggc     2940



cttctcagac tttaacaagc actggaaatt ttaaatttgg agatcaggga ggattcaaaa     3000



taggtgtgtc atctgattct gggtctataa accccatgag tgaaggcttt aaattttcta     3060



aaccaatagg agattttaaa tttggagttt catctgaatc taagcccgaa gaagttaaaa     3120



aagatagtaa gaatgataat tttaagtttg gactttcttc tggtttaagc aacccagttt     3180



ctttaactcc atttcaattt ggggtatcta atcttggaca ggaagaaaag aaagaggaac     3240



tgcccaaatc ttcctctgca ggttttagct ttggtacagg tgttattaac tccacccctg     3300



ctcctgctaa caccatagtg acctctgaga acaagagcag cttcaacctt ggaaccatag     3360



aaaccaagag tgcttcagtg gctcctttca catgtaagac atcagaagct aaaaaagaag     3420



aaatgcctgc caccaaagga ggattctctt ttggcaacgt ggagcctgcc tctctgccat     3480



ctgcctcagt gtttgttttg ggaaggacag aagagaaaca gcaagagcct gtcacttcta     3540



cttccctagt ttttgggaag aaagctgaca atgaagagcc aaagtgtcaa ccagtgtttt     3600



cctttgggaa ttcagagcaa accaaagatg agaattcttc aaagtccaca tttagtttta     3660



gtatgacaaa accatctgag aaggaatctg aacagccagc aaaagccact tttgcctttg     3720



gagctcaaac tagtactaca gctgatcaag gtgcagcaaa gccagttttt agtttcttga     3780



acaacagttc ctctagttca agtacaccag ccacttctgc tggtggtggc atatttggta     3840



gttccacctc ttcctccaat ccacctgtgg ctacctttgt gtttggacag tccagcaatc     3900



ctgtgagcag ctctgccttt ggtaacactg ctgaatccag cacctctcag tctttgctat     3960



tttctcaaga tagcaaacta gcaaccacat ccagcacagg tacagctgtc accccatttg     4020



tctttggtcc aggagccagc agtaataata ctaccacctc tggtttcggc tttggagcca     4080



caaccacatc tagctctgca ggatcctcct ttgtatttgg aactggaccc tcagcaccat     4140



ctgccagtcc agcatttggt gctaaccaga ccccaacatt tggacaaagt caaggtgcca     4200



gccagcccaa tcccccaggc tttggatcta tatcatcttc cacagcatta tttcccactg     4260



gttctcagcc tgcaccacct acttttggga cagtgtcaag cagtagccag ccccctgtgt     4320



ttggacagca acctagtcag tctgcatttg gctctggaac aactcctaat tctagttcgg     4380



ctttccagtt tggcagcagc actacaaatt tcaacttcac aaacaacagt ccatcaggag     4440



tgttcacatt tggtgcaaat tctagcacac ctgcagcctc agcccagcct tcaggctcgg     4500



ggggctttcc atttaaccag tctccagcag catttacagt ggggtcaaat gggaaaaatg     4560



tgttctcttc ttctggaact tcattctctg gtcgcaagat aaagactgct gttagacgca     4620



ggaaataaag gtcacattgg tgttgtactc aattttaaca acagctggtg ccctgctttc     4680



agatactgga ttgtactttg tgctggggtt atctgaagtc agatctgcct aaggacttct     4740



ttaattttgg aattttcctc ctttctcttt cgttacagaa gccccaccct gcctcaccca     4800



ccctttttta aataaataaa tagctagact ggtgactgat tcttcagcaa aaatatttta     4860



tgatccagca gattattcac tgatttgaca tagtctggct gtacccagga atggagcctg     4920



cacggtgaat ggctttgtat agaacctctt tgtctacacc attatgtgcg ctgataagcg     4980



ttcatggaac gcgttgaaat tgtaattata tctgaggaat tctgtataga ttagaattct     5040



gtatagatta gagagtgttg aaacggatga tttctatgct gagtttgtgc tggtgtatgt     5100



gtgaagtgag tgagttgggt gtattgtgcg ctaaactttt ctgatagagg aagcctgatt     5160



aaagaatggt ccgtgctaag gacttgttag atctagttca ctctccattt aataattata     5220



tgctatttct atattttcat tctcctatca cctgtcttgc ctttttcatt attttattat     5280



gaaacttgtg taaatacaat tttgtttctg tactttttgg cataacataa atctgtgaac     5340



ttgaaatttg aattttgtgt tagagatttt tttgttgttt gtttagtctt gtctcagatt     5400



ttattatgta aatcccatta ttcaaagttg cctaaatcca tttggaaatc tttaaaaaaa     5460



aaattgggga ttcttaaagt tgaatttatt ggcttttctg atccagtttt gtttggacca     5520



aaaaccagta ttgtacaaag tattaagcat atatttttat atttactaaa atggactgtg     5580



gtgactttgg ataataagga aaagtttaat attaaagcca tgtttattac agtataatta     5640



acatgttaaa ccatgggata aatgccatca ataaaaaatt atgacat                   5687





<210>  195

<211>  1475

<212>  PRT

<213>  Homo sapiens



<400>  195



Met Ala Ser Gly Ala Gly Gly Val Gly Gly Gly Gly Gly Gly Lys Ile 

1               5                   10                  15      





Arg Thr Arg Arg Cys His Gln Gly Pro Ile Lys Pro Tyr Gln Gln Gly 

            20                  25                  30          





Arg Gln Gln His Gln Gly Ile Leu Ser Arg Val Thr Glu Ser Val Lys 

        35                  40                  45              





Asn Ile Val Pro Gly Trp Leu Gln Arg Tyr Phe Asn Lys Asn Glu Asp 

    50                  55                  60                  





Val Cys Ser Cys Ser Thr Asp Thr Ser Glu Val Pro Arg Trp Pro Glu 

65                  70                  75                  80  





Asn Lys Glu Asp His Leu Val Tyr Ala Asp Glu Glu Ser Ser Asn Ile 

                85                  90                  95      





Thr Asp Gly Arg Ile Thr Pro Glu Pro Ala Val Ser Asn Thr Glu Glu 

            100                 105                 110         





Pro Ser Thr Thr Ser Thr Ala Ser Asn Tyr Pro Asp Val Leu Thr Arg 

        115                 120                 125             





Pro Ser Leu His Arg Ser His Leu Asn Phe Ser Met Leu Glu Ser Pro 

    130                 135                 140                 





Ala Leu His Cys Gln Pro Ser Thr Ser Ser Ala Phe Pro Ile Gly Ser 

145                 150                 155                 160 





Ser Gly Phe Ser Leu Val Lys Glu Ile Lys Asp Ser Thr Ser Gln His 

                165                 170                 175     





Asp Asp Asp Asn Ile Ser Thr Thr Ser Gly Phe Ser Ser Arg Ala Ser 

            180                 185                 190         





Asp Lys Asp Ile Thr Val Ser Lys Asn Thr Ser Leu Pro Pro Leu Trp 

        195                 200                 205             





Ser Pro Glu Ala Glu Arg Ser His Ser Leu Ser Gln His Thr Ala Thr 

    210                 215                 220                 





Ser Ser Lys Lys Pro Ala Phe Asn Leu Ser Ala Phe Gly Thr Leu Ser 

225                 230                 235                 240 





Pro Ser Leu Gly Asn Ser Ser Ile Leu Lys Thr Ser Gln Leu Gly Asp 

                245                 250                 255     





Ser Pro Phe Tyr Pro Gly Lys Thr Thr Tyr Gly Gly Ala Ala Ala Ala 

            260                 265                 270         





Val Arg Gln Ser Lys Leu Arg Asn Thr Pro Tyr Gln Ala Pro Val Arg 

        275                 280                 285             





Arg Gln Met Lys Ala Lys Gln Leu Ser Ala Gln Ser Tyr Gly Val Thr 

    290                 295                 300                 





Ser Ser Thr Ala Arg Arg Ile Leu Gln Ser Leu Glu Lys Met Ser Ser 

305                 310                 315                 320 





Pro Leu Ala Asp Ala Lys Arg Ile Pro Ser Ile Val Ser Ser Pro Leu 

                325                 330                 335     





Asn Ser Pro Leu Asp Arg Ser Gly Ile Asp Ile Thr Asp Phe Gln Ala 

            340                 345                 350         





Lys Arg Glu Lys Val Asp Ser Gln Tyr Pro Pro Val Gln Arg Leu Met 

        355                 360                 365             





Thr Pro Lys Pro Val Ser Ile Ala Thr Asn Arg Ser Val Tyr Phe Lys 

    370                 375                 380                 





Pro Ser Leu Thr Pro Ser Gly Glu Phe Arg Lys Thr Asn Gln Arg Ile 

385                 390                 395                 400 





Asp Asn Lys Cys Ser Thr Gly Tyr Glu Lys Asn Met Thr Pro Gly Gln 

                405                 410                 415     





Asn Arg Glu Gln Arg Glu Ser Gly Phe Ser Tyr Pro Asn Phe Ser Leu 

            420                 425                 430         





Pro Ala Ala Asn Gly Leu Ser Ser Gly Val Gly Gly Gly Gly Gly Lys 

        435                 440                 445             





Met Arg Arg Glu Arg Thr Arg Phe Val Ala Ser Lys Pro Leu Glu Glu 

    450                 455                 460                 





Glu Glu Met Glu Val Pro Val Leu Pro Lys Ile Ser Leu Pro Ile Thr 

465                 470                 475                 480 





Ser Ser Ser Leu Pro Thr Phe Asn Phe Ser Ser Pro Glu Ile Thr Thr 

                485                 490                 495     





Ser Ser Pro Ser Pro Ile Asn Ser Ser Gln Ala Leu Thr Asn Lys Val 

            500                 505                 510         





Gln Met Thr Ser Pro Ser Ser Thr Gly Ser Pro Met Phe Lys Phe Ser 

        515                 520                 525             





Ser Pro Ile Val Lys Ser Thr Glu Ala Asn Val Leu Pro Pro Ser Ser 

    530                 535                 540                 





Ile Gly Phe Thr Phe Ser Val Pro Val Ala Lys Thr Ala Glu Leu Ser 

545                 550                 555                 560 





Gly Ser Ser Ser Thr Leu Glu Pro Ile Ile Ser Ser Ser Ala His His 

                565                 570                 575     





Val Thr Thr Val Asn Ser Thr Asn Cys Lys Lys Thr Pro Pro Glu Asp 

            580                 585                 590         





Cys Glu Gly Pro Phe Arg Pro Ala Glu Ile Leu Lys Glu Gly Ser Val 

        595                 600                 605             





Leu Asp Ile Leu Lys Ser Pro Gly Phe Ala Ser Pro Lys Ile Asp Ser 

    610                 615                 620                 





Val Ala Ala Gln Pro Thr Ala Thr Ser Pro Val Val Tyr Thr Arg Pro 

625                 630                 635                 640 





Ala Ile Ser Ser Phe Ser Ser Ser Gly Ile Gly Phe Gly Glu Ser Leu 

                645                 650                 655     





Lys Ala Gly Ser Ser Trp Gln Cys Asp Thr Cys Leu Leu Gln Asn Lys 

            660                 665                 670         





Val Thr Asp Asn Lys Cys Ile Ala Cys Gln Ala Ala Lys Leu Ser Pro 

        675                 680                 685             





Arg Asp Thr Ala Lys Gln Thr Gly Ile Glu Thr Pro Asn Lys Ser Gly 

    690                 695                 700                 





Lys Thr Thr Leu Ser Ala Ser Gly Thr Gly Phe Gly Asp Lys Phe Lys 

705                 710                 715                 720 





Pro Val Ile Gly Thr Trp Asp Cys Asp Thr Cys Leu Val Gln Asn Lys 

                725                 730                 735     





Pro Glu Ala Ile Lys Cys Val Ala Cys Glu Thr Pro Lys Pro Gly Thr 

            740                 745                 750         





Cys Val Lys Arg Ala Leu Thr Leu Thr Val Val Ser Glu Ser Ala Glu 

        755                 760                 765             





Thr Met Thr Ala Ser Ser Ser Ser Cys Thr Val Thr Thr Gly Thr Leu 

    770                 775                 780                 





Gly Phe Gly Asp Lys Phe Lys Arg Pro Ile Gly Ser Trp Glu Cys Ser 

785                 790                 795                 800 





Val Cys Cys Val Ser Asn Asn Ala Glu Asp Asn Lys Cys Val Ser Cys 

                805                 810                 815     





Met Ser Glu Lys Pro Gly Ser Ser Val Pro Ala Ser Ser Ser Ser Thr 

            820                 825                 830         





Val Pro Val Ser Leu Pro Ser Gly Gly Ser Leu Gly Leu Glu Lys Phe 

        835                 840                 845             





Lys Lys Pro Glu Gly Ser Trp Asp Cys Glu Leu Cys Leu Val Gln Asn 

    850                 855                 860                 





Lys Ala Asp Ser Thr Lys Cys Leu Ala Cys Glu Ser Ala Lys Pro Gly 

865                 870                 875                 880 





Thr Lys Ser Gly Phe Lys Gly Phe Asp Thr Ser Ser Ser Ser Ser Asn 

                885                 890                 895     





Ser Ala Ala Ser Ser Ser Phe Lys Phe Gly Val Ser Ser Ser Ser Ser 

            900                 905                 910         





Gly Pro Ser Gln Thr Leu Thr Ser Thr Gly Asn Phe Lys Phe Gly Asp 

        915                 920                 925             





Gln Gly Gly Phe Lys Ile Gly Val Ser Ser Asp Ser Gly Ser Ile Asn 

    930                 935                 940                 





Pro Met Ser Glu Gly Phe Lys Phe Ser Lys Pro Ile Gly Asp Phe Lys 

945                 950                 955                 960 





Phe Gly Val Ser Ser Glu Ser Lys Pro Glu Glu Val Lys Lys Asp Ser 

                965                 970                 975     





Lys Asn Asp Asn Phe Lys Phe Gly Leu Ser Ser Gly Leu Ser Asn Pro 

            980                 985                 990         





Val Ser Leu Thr Pro Phe Gln Phe  Gly Val Ser Asn Leu  Gly Gln Glu 

        995                 1000                 1005             





Glu Lys  Lys Glu Glu Leu Pro  Lys Ser Ser Ser Ala  Gly Phe Ser 

    1010                 1015                 1020             





Phe Gly  Thr Gly Val Ile Asn  Ser Thr Pro Ala Pro  Ala Asn Thr 

    1025                 1030                 1035             





Ile Val  Thr Ser Glu Asn Lys  Ser Ser Phe Asn Leu  Gly Thr Ile 

    1040                 1045                 1050             





Glu Thr  Lys Ser Ala Ser Val  Ala Pro Phe Thr Cys  Lys Thr Ser 

    1055                 1060                 1065             





Glu Ala  Lys Lys Glu Glu Met  Pro Ala Thr Lys Gly  Gly Phe Ser 

    1070                 1075                 1080             





Phe Gly  Asn Val Glu Pro Ala  Ser Leu Pro Ser Ala  Ser Val Phe 

    1085                 1090                 1095             





Val Leu  Gly Arg Thr Glu Glu  Lys Gln Gln Glu Pro  Val Thr Ser 

    1100                 1105                 1110             





Thr Ser  Leu Val Phe Gly Lys  Lys Ala Asp Asn Glu  Glu Pro Lys 

    1115                 1120                 1125             





Cys Gln  Pro Val Phe Ser Phe  Gly Asn Ser Glu Gln  Thr Lys Asp 

    1130                 1135                 1140             





Glu Asn  Ser Ser Lys Ser Thr  Phe Ser Phe Ser Met  Thr Lys Pro 

    1145                 1150                 1155             





Ser Glu  Lys Glu Ser Glu Gln  Pro Ala Lys Ala Thr  Phe Ala Phe 

    1160                 1165                 1170             





Gly Ala  Gln Thr Ser Thr Thr  Ala Asp Gln Gly Ala  Ala Lys Pro 

    1175                 1180                 1185             





Val Phe  Ser Phe Leu Asn Asn  Ser Ser Ser Ser Ser  Ser Thr Pro 

    1190                 1195                 1200             





Ala Thr  Ser Ala Gly Gly Gly  Ile Phe Gly Ser Ser  Thr Ser Ser 

    1205                 1210                 1215             





Ser Asn  Pro Pro Val Ala Thr  Phe Val Phe Gly Gln  Ser Ser Asn 

    1220                 1225                 1230             





Pro Val  Ser Ser Ser Ala Phe  Gly Asn Thr Ala Glu  Ser Ser Thr 

    1235                 1240                 1245             





Ser Gln  Ser Leu Leu Phe Ser  Gln Asp Ser Lys Leu  Ala Thr Thr 

    1250                 1255                 1260             





Ser Ser  Thr Gly Thr Ala Val  Thr Pro Phe Val Phe  Gly Pro Gly 

    1265                 1270                 1275             





Ala Ser  Ser Asn Asn Thr Thr  Thr Ser Gly Phe Gly  Phe Gly Ala 

    1280                 1285                 1290             





Thr Thr  Thr Ser Ser Ser Ala  Gly Ser Ser Phe Val  Phe Gly Thr 

    1295                 1300                 1305             





Gly Pro  Ser Ala Pro Ser Ala  Ser Pro Ala Phe Gly  Ala Asn Gln 

    1310                 1315                 1320             





Thr Pro  Thr Phe Gly Gln Ser  Gln Gly Ala Ser Gln  Pro Asn Pro 

    1325                 1330                 1335             





Pro Gly  Phe Gly Ser Ile Ser  Ser Ser Thr Ala Leu  Phe Pro Thr 

    1340                 1345                 1350             





Gly Ser  Gln Pro Ala Pro Pro  Thr Phe Gly Thr Val  Ser Ser Ser 

    1355                 1360                 1365             





Ser Gln  Pro Pro Val Phe Gly  Gln Gln Pro Ser Gln  Ser Ala Phe 

    1370                 1375                 1380             





Gly Ser  Gly Thr Thr Pro Asn  Ser Ser Ser Ala Phe  Gln Phe Gly 

    1385                 1390                 1395             





Ser Ser  Thr Thr Asn Phe Asn  Phe Thr Asn Asn Ser  Pro Ser Gly 

    1400                 1405                 1410             





Val Phe  Thr Phe Gly Ala Asn  Ser Ser Thr Pro Ala  Ala Ser Ala 

    1415                 1420                 1425             





Gln Pro  Ser Gly Ser Gly Gly  Phe Pro Phe Asn Gln  Ser Pro Ala 

    1430                 1435                 1440             





Ala Phe  Thr Val Gly Ser Asn  Gly Lys Asn Val Phe  Ser Ser Ser 

    1445                 1450                 1455             





Gly Thr  Ser Phe Ser Gly Arg  Lys Ile Lys Thr Ala  Val Arg Arg 

    1460                 1465                 1470             





Arg Lys  

    1475 





<210>  196

<211>  4200

<212>  DNA

<213>  Homo sapiens



<400>  196

gactctcgcc tgacttccta atttgctact tatccccagc gttggtcccg gcgaggatat       60



gctgagattt atggcactgt tggctgcatt tttggagaac agcaagcagc ttcttttcag      120



ataatcccac cgtttctggc atgtcagata tggattatcc tttacaagga cctggtttgc      180



tgtccgtacc caaccttcca gagatcagtt ccatccgaag agttcctctc ccacctgaac      240



ttgttgagca gtttggacat atgcagtgta attgcatgat gggtgtgttc cctcctatca      300



gcagagcttg gctcacaatt gacagtgata tattcatgtg gaactatgag gatggaggag      360



accttgccta ttttgatgga cttagtgaga ctattcttgc tgtggggctt gtgaagccaa      420



aagcaggcat ctttcaacct catgtgcgac acctcctggt tttggcgacc cctgtagaca      480



tagtaattct tggactcagc tatgctaatt tgcaaacagg ttctggagtt cttaatgata      540



gtttgtctgg tggaatgcag ttgcttccag atcctttata ttctcttcct actgataata      600



cttacctttt aacaataact tccactgata atggcagaat tttcttggct ggaaaggatg      660



gctgtttata tgaagtagcc taccaggctg aagcagggtg gtttagccaa agatgtagga      720



aaataaacca ctcaaagagc tcactttctt tccttgttcc ttccttgcta caattcacgt      780



tctcagaaga tgatcctatt cttcaaattg caattgataa ttctagaaat attttatata      840



cacgatctga gaaaggagta atacaggtgt atgatttggg acaagatgga caaggaatga      900



gcagagttgc ctctgtgtca cagaatgcca ttgtctctgc tgctggtaac attgctagga      960



ccatcgatcg ttctgttttt aaaccaattg tccaaatagc agtgattgaa aattctgaat     1020



cactggactg tcagttattg gctgtcacac atgcaggtgt taggttatat tttagcactt     1080



gtccattcag acagccatta gcacggccta atacactgac gctggttcat gtccgcttac     1140



ctcctggatt ctcagcatct tcaaccgtgg aaaagccttc aaaagtacat agagctcttt     1200



atagtaaagg tattctattg atggcagcct cagaaaatga ggataatgat attttatggt     1260



gtgtcaacca tgatactttt cctttccaaa agccaatgat ggaaacccag atgacagctg     1320



gtgttgatgg tcattcctgg gctctttctg cgatagatga attgaaagta gataaaataa     1380



ttacaccttt aaacaaggat catattccaa taactgattc accagttgtt gtacagcagc     1440



acatgttacc tccgaagaaa tttgttctcc tctcagcaca ggggagcctt atgtttcata     1500



aacttagacc tgtagatcaa ctgaggcatc tacttgtgag taatgtggga ggagatggag     1560



aagagattga aagattcttt aaattacatc aggaagacca ggcttgtgca acttgcctta     1620



ttcttgcttg ctccactgct gcctgtgata gagaagtatc tgcctgggct actcgggctt     1680



tctttaggta tggtggtgaa gcacagatga gatttccaac cactcttccg cctccaagta     1740



atgttggtcc catcttgggg tctcctgtct attctagttc tcctgttcct agtggtagtc     1800



cctatccaaa tccatccttt ttgggaacac cgtctcatgg tatacagcct cctgccatgt     1860



caactccagt gtgtgctctg ggaaacccag caactcaggc cacaaatatg agttgtgtga     1920



ctggaccaga gattgtgtac tctggaaaac acaatggtat ttgcatttac ttttctcgga     1980



tcatgggaaa catttgggat gcaagcttag ttgtggagag aatattcaag agtggcaaca     2040



gagagatcac tgcaattgaa agtagtgttc cctgccaact gctagagtca gtgctacaag     2100



aactaaaggg tttgcaggaa tttctagaca gaaactccca gtttgcagga ggaccattag     2160



gaaatccaaa tactactgct aaagtgcagc agaggctgat aggattcatg cgtcctgaaa     2220



acggaaatcc ccagcaaatg caacaggaac tgcagaggaa gtttcatgag gctcaactaa     2280



gtgaaaagat ttcacttcag gcaattcagc agttggttcg aaaatcatat caggctctgg     2340



ctttatggaa acttctttgt gaacatcaat tcactatcat tgtggcagaa cttcagaagg     2400



aacttcaaga gcagctgaag atcaccacct ttaaagatct tgtaatcagg gacaaagaac     2460



tcacaggggc attaattgct tctcttatca actgctacat cagagataat gccgctgttg     2520



atggcattag tttacattta caggatatct gcccacttct atatagcact gatgatgcaa     2580



tttgttctaa ggcaaatgag cttctccagc gttcccgaca agttcaaaat aagactgaaa     2640



aagaaagaat gttaagggaa tcattaaagg aatatcaaaa aattagcaat caagtggacc     2700



tttccaatgt ttgtgctcag tatagacaag tgagatttta tgagggtgtg gtggaacttt     2760



ctcttacggc tgcagagaaa aaagatcctc aaggtcttgg gcttcatttc tataaacatg     2820



gagaaccaga agaagacata gttggacttc aggccttcca agaaagatta aacagttaca     2880



aatgcattac agacacactt caagaactgg taaatcaaag taaggccgct cctcagtctc     2940



ccagtgtacc caaaaaacct ggtcctccag tgttgtcatc tgatccaaat atgctgagta     3000



atgaagaagc aggacatcat tttgaacaaa tgcttaaatt gtcacagcga tccaaggatg     3060



agctctttag tattgccctt tataattggc taatacaagt cgaccttgca gataagctgc     3120



tacaggttgc ttctccattt ctggagccac atctagtccg aatggccaaa gttgatcaaa     3180



acagagttcg ttatatggat ttactctggc ggtattacga gaagaacaga agtttcagta     3240



atgctgctcg tgtactgtcc agactggctg acatgcatag cacagaaatt tcacttcagc     3300



agcgactaga gtacattgct cgagccattc ttagtgccaa aagttccact gccatttcat     3360



caatagctgc cgatggtgaa tttcttcatg aattagaaga aaaaatggag gttgctagga     3420



tccaacttca gatacaggag acactacaaa ggcagtattc ccatcattct tctgtacagg     3480



atgcagtttc tcagctggat tctgagctga tggacataac taagctttat ggggaatttg     3540



ctgacccatt taaacttgca gagtgcaaac ttgcaataat tcattgtgcc ggttattcag     3600



accctatatt ggtgcagaca ctttggcaag atatcataga gaaagaattg agtgacagtg     3660



tgacattgag ctcctcggat agaatgcatg ctcttagtct caagattgtt ctccttggca     3720



aaatttatgc tggcacacca cgcttctttc ctttagattt tattgtacag tttttagaac     3780



agcaggtttg tactttgaac tgggatgtgg gcttcgtaat acagacaatg aatgaaattg     3840



gagtaccatt acctagacta ctagaagttt atgatcagtt gttcaaatca cgggatccat     3900



tctggaacag aatgaagaag ccactgcacc ttttggattg tatacatgta ttattgataa     3960



gatatgttga gaatcccagc caagttttaa attgtgaaag gagaagattt acaaatctct     4020



gcctggatgc tgtttgtggt taccttgttg agctccagtc tatgagctcg tcagtagcag     4080



tacaagccat cactgggaat tttaaatctc ttcaagctaa attagaacgg cttcattaat     4140



tactgtgata tactttcatc cgttttatga tctgtaaaat aaaaactcag ctgggtccag     4200





<210>  197

<211>  1332

<212>  PRT

<213>  Homo sapiens



<400>  197



Met Ser Asp Met Asp Tyr Pro Leu Gln Gly Pro Gly Leu Leu Ser Val 

1               5                   10                  15      





Pro Asn Leu Pro Glu Ile Ser Ser Ile Arg Arg Val Pro Leu Pro Pro 

            20                  25                  30          





Glu Leu Val Glu Gln Phe Gly His Met Gln Cys Asn Cys Met Met Gly 

        35                  40                  45              





Val Phe Pro Pro Ile Ser Arg Ala Trp Leu Thr Ile Asp Ser Asp Ile 

    50                  55                  60                  





Phe Met Trp Asn Tyr Glu Asp Gly Gly Asp Leu Ala Tyr Phe Asp Gly 

65                  70                  75                  80  





Leu Ser Glu Thr Ile Leu Ala Val Gly Leu Val Lys Pro Lys Ala Gly 

                85                  90                  95      





Ile Phe Gln Pro His Val Arg His Leu Leu Val Leu Ala Thr Pro Val 

            100                 105                 110         





Asp Ile Val Ile Leu Gly Leu Ser Tyr Ala Asn Leu Gln Thr Gly Ser 

        115                 120                 125             





Gly Val Leu Asn Asp Ser Leu Ser Gly Gly Met Gln Leu Leu Pro Asp 

    130                 135                 140                 





Pro Leu Tyr Ser Leu Pro Thr Asp Asn Thr Tyr Leu Leu Thr Ile Thr 

145                 150                 155                 160 





Ser Thr Asp Asn Gly Arg Ile Phe Leu Ala Gly Lys Asp Gly Cys Leu 

                165                 170                 175     





Tyr Glu Val Ala Tyr Gln Ala Glu Ala Gly Trp Phe Ser Gln Arg Cys 

            180                 185                 190         





Arg Lys Ile Asn His Ser Lys Ser Ser Leu Ser Phe Leu Val Pro Ser 

        195                 200                 205             





Leu Leu Gln Phe Thr Phe Ser Glu Asp Asp Pro Ile Leu Gln Ile Ala 

    210                 215                 220                 





Ile Asp Asn Ser Arg Asn Ile Leu Tyr Thr Arg Ser Glu Lys Gly Val 

225                 230                 235                 240 





Ile Gln Val Tyr Asp Leu Gly Gln Asp Gly Gln Gly Met Ser Arg Val 

                245                 250                 255     





Ala Ser Val Ser Gln Asn Ala Ile Val Ser Ala Ala Gly Asn Ile Ala 

            260                 265                 270         





Arg Thr Ile Asp Arg Ser Val Phe Lys Pro Ile Val Gln Ile Ala Val 

        275                 280                 285             





Ile Glu Asn Ser Glu Ser Leu Asp Cys Gln Leu Leu Ala Val Thr His 

    290                 295                 300                 





Ala Gly Val Arg Leu Tyr Phe Ser Thr Cys Pro Phe Arg Gln Pro Leu 

305                 310                 315                 320 





Ala Arg Pro Asn Thr Leu Thr Leu Val His Val Arg Leu Pro Pro Gly 

                325                 330                 335     





Phe Ser Ala Ser Ser Thr Val Glu Lys Pro Ser Lys Val His Arg Ala 

            340                 345                 350         





Leu Tyr Ser Lys Gly Ile Leu Leu Met Ala Ala Ser Glu Asn Glu Asp 

        355                 360                 365             





Asn Asp Ile Leu Trp Cys Val Asn His Asp Thr Phe Pro Phe Gln Lys 

    370                 375                 380                 





Pro Met Met Glu Thr Gln Met Thr Ala Gly Val Asp Gly His Ser Trp 

385                 390                 395                 400 





Ala Leu Ser Ala Ile Asp Glu Leu Lys Val Asp Lys Ile Ile Thr Pro 

                405                 410                 415     





Leu Asn Lys Asp His Ile Pro Ile Thr Asp Ser Pro Val Val Val Gln 

            420                 425                 430         





Gln His Met Leu Pro Pro Lys Lys Phe Val Leu Leu Ser Ala Gln Gly 

        435                 440                 445             





Ser Leu Met Phe His Lys Leu Arg Pro Val Asp Gln Leu Arg His Leu 

    450                 455                 460                 





Leu Val Ser Asn Val Gly Gly Asp Gly Glu Glu Ile Glu Arg Phe Phe 

465                 470                 475                 480 





Lys Leu His Gln Glu Asp Gln Ala Cys Ala Thr Cys Leu Ile Leu Ala 

                485                 490                 495     





Cys Ser Thr Ala Ala Cys Asp Arg Glu Val Ser Ala Trp Ala Thr Arg 

            500                 505                 510         





Ala Phe Phe Arg Tyr Gly Gly Glu Ala Gln Met Arg Phe Pro Thr Thr 

        515                 520                 525             





Leu Pro Pro Pro Ser Asn Val Gly Pro Ile Leu Gly Ser Pro Val Tyr 

    530                 535                 540                 





Ser Ser Ser Pro Val Pro Ser Gly Ser Pro Tyr Pro Asn Pro Ser Phe 

545                 550                 555                 560 





Leu Gly Thr Pro Ser His Gly Ile Gln Pro Pro Ala Met Ser Thr Pro 

                565                 570                 575     





Val Cys Ala Leu Gly Asn Pro Ala Thr Gln Ala Thr Asn Met Ser Cys 

            580                 585                 590         





Val Thr Gly Pro Glu Ile Val Tyr Ser Gly Lys His Asn Gly Ile Cys 

        595                 600                 605             





Ile Tyr Phe Ser Arg Ile Met Gly Asn Ile Trp Asp Ala Ser Leu Val 

    610                 615                 620                 





Val Glu Arg Ile Phe Lys Ser Gly Asn Arg Glu Ile Thr Ala Ile Glu 

625                 630                 635                 640 





Ser Ser Val Pro Cys Gln Leu Leu Glu Ser Val Leu Gln Glu Leu Lys 

                645                 650                 655     





Gly Leu Gln Glu Phe Leu Asp Arg Asn Ser Gln Phe Ala Gly Gly Pro 

            660                 665                 670         





Leu Gly Asn Pro Asn Thr Thr Ala Lys Val Gln Gln Arg Leu Ile Gly 

        675                 680                 685             





Phe Met Arg Pro Glu Asn Gly Asn Pro Gln Gln Met Gln Gln Glu Leu 

    690                 695                 700                 





Gln Arg Lys Phe His Glu Ala Gln Leu Ser Glu Lys Ile Ser Leu Gln 

705                 710                 715                 720 





Ala Ile Gln Gln Leu Val Arg Lys Ser Tyr Gln Ala Leu Ala Leu Trp 

                725                 730                 735     





Lys Leu Leu Cys Glu His Gln Phe Thr Ile Ile Val Ala Glu Leu Gln 

            740                 745                 750         





Lys Glu Leu Gln Glu Gln Leu Lys Ile Thr Thr Phe Lys Asp Leu Val 

        755                 760                 765             





Ile Arg Asp Lys Glu Leu Thr Gly Ala Leu Ile Ala Ser Leu Ile Asn 

    770                 775                 780                 





Cys Tyr Ile Arg Asp Asn Ala Ala Val Asp Gly Ile Ser Leu His Leu 

785                 790                 795                 800 





Gln Asp Ile Cys Pro Leu Leu Tyr Ser Thr Asp Asp Ala Ile Cys Ser 

                805                 810                 815     





Lys Ala Asn Glu Leu Leu Gln Arg Ser Arg Gln Val Gln Asn Lys Thr 

            820                 825                 830         





Glu Lys Glu Arg Met Leu Arg Glu Ser Leu Lys Glu Tyr Gln Lys Ile 

        835                 840                 845             





Ser Asn Gln Val Asp Leu Ser Asn Val Cys Ala Gln Tyr Arg Gln Val 

    850                 855                 860                 





Arg Phe Tyr Glu Gly Val Val Glu Leu Ser Leu Thr Ala Ala Glu Lys 

865                 870                 875                 880 





Lys Asp Pro Gln Gly Leu Gly Leu His Phe Tyr Lys His Gly Glu Pro 

                885                 890                 895     





Glu Glu Asp Ile Val Gly Leu Gln Ala Phe Gln Glu Arg Leu Asn Ser 

            900                 905                 910         





Tyr Lys Cys Ile Thr Asp Thr Leu Gln Glu Leu Val Asn Gln Ser Lys 

        915                 920                 925             





Ala Ala Pro Gln Ser Pro Ser Val Pro Lys Lys Pro Gly Pro Pro Val 

    930                 935                 940                 





Leu Ser Ser Asp Pro Asn Met Leu Ser Asn Glu Glu Ala Gly His His 

945                 950                 955                 960 





Phe Glu Gln Met Leu Lys Leu Ser Gln Arg Ser Lys Asp Glu Leu Phe 

                965                 970                 975     





Ser Ile Ala Leu Tyr Asn Trp Leu Ile Gln Val Asp Leu Ala Asp Lys 

            980                 985                 990         





Leu Leu Gln Val Ala Ser Pro Phe  Leu Glu Pro His Leu  Val Arg Met 

        995                 1000                 1005             





Ala Lys  Val Asp Gln Asn Arg  Val Arg Tyr Met Asp  Leu Leu Trp 

    1010                 1015                 1020             





Arg Tyr  Tyr Glu Lys Asn Arg  Ser Phe Ser Asn Ala  Ala Arg Val 

    1025                 1030                 1035             





Leu Ser  Arg Leu Ala Asp Met  His Ser Thr Glu Ile  Ser Leu Gln 

    1040                 1045                 1050             





Gln Arg  Leu Glu Tyr Ile Ala  Arg Ala Ile Leu Ser  Ala Lys Ser 

    1055                 1060                 1065             





Ser Thr  Ala Ile Ser Ser Ile  Ala Ala Asp Gly Glu  Phe Leu His 

    1070                 1075                 1080             





Glu Leu  Glu Glu Lys Met Glu  Val Ala Arg Ile Gln  Leu Gln Ile 

    1085                 1090                 1095             





Gln Glu  Thr Leu Gln Arg Gln  Tyr Ser His His Ser  Ser Val Gln 

    1100                 1105                 1110             





Asp Ala  Val Ser Gln Leu Asp  Ser Glu Leu Met Asp  Ile Thr Lys 

    1115                 1120                 1125             





Leu Tyr  Gly Glu Phe Ala Asp  Pro Phe Lys Leu Ala  Glu Cys Lys 

    1130                 1135                 1140             





Leu Ala  Ile Ile His Cys Ala  Gly Tyr Ser Asp Pro  Ile Leu Val 

    1145                 1150                 1155             





Gln Thr  Leu Trp Gln Asp Ile  Ile Glu Lys Glu Leu  Ser Asp Ser 

    1160                 1165                 1170             





Val Thr  Leu Ser Ser Ser Asp  Arg Met His Ala Leu  Ser Leu Lys 

    1175                 1180                 1185             





Ile Val  Leu Leu Gly Lys Ile  Tyr Ala Gly Thr Pro  Arg Phe Phe 

    1190                 1195                 1200             





Pro Leu  Asp Phe Ile Val Gln  Phe Leu Glu Gln Gln  Val Cys Thr 

    1205                 1210                 1215             





Leu Asn  Trp Asp Val Gly Phe  Val Ile Gln Thr Met  Asn Glu Ile 

    1220                 1225                 1230             





Gly Val  Pro Leu Pro Arg Leu  Leu Glu Val Tyr Asp  Gln Leu Phe 

    1235                 1240                 1245             





Lys Ser  Arg Asp Pro Phe Trp  Asn Arg Met Lys Lys  Pro Leu His 

    1250                 1255                 1260             





Leu Leu  Asp Cys Ile His Val  Leu Leu Ile Arg Tyr  Val Glu Asn 

    1265                 1270                 1275             





Pro Ser  Gln Val Leu Asn Cys  Glu Arg Arg Arg Phe  Thr Asn Leu 

    1280                 1285                 1290             





Cys Leu  Asp Ala Val Cys Gly  Tyr Leu Val Glu Leu  Gln Ser Met 

    1295                 1300                 1305             





Ser Ser  Ser Val Ala Val Gln  Ala Ile Thr Gly Asn  Phe Lys Ser 

    1310                 1315                 1320             





Leu Gln  Ala Lys Leu Glu Arg  Leu His 

    1325                 1330         





<210>  198

<211>  4355

<212>  DNA

<213>  Homo sapiens



<400>  198

aaggcgctcg tttggcgcgc gcgccctagg cggcggatct aagctaactt cttggatctt       60



ttcttgtttc tccttggttt ttgacttttt ctggaccctg gtgtctacga tttccgagat      120



gccgtcttct ttgttgggcg cggcgatgcc ggcctctaca tctgccgcag ccctgcagga      180



agctctggaa aatgctggac ggctcatcga ccgtcagttg caagaggacc gcatgtaccc      240



ggacctttcc gagctgctta tggtgtctgc cccaaataat cccaccgttt ctggcatgtc      300



agatatggat tatcctttac aaggacctgg tttgctgtcc gtacccaacc ttccagagat      360



cagttccatc cgaagagttc ctctcccacc tgaacttgtt gagcagtttg gacatatgca      420



gtgtaattgc atgatgggtg tgttccctcc tatcagcaga gcttggctca caattgacag      480



tgatatattc atgtggaact atgaggatgg aggagacctt gcctattttg atggacttag      540



tgagactatt cttgctgtgg ggcttgtgaa gccaaaagca ggcatctttc aacctcatgt      600



gcgacacctc ctggttttgg cgacccctgt agacatagta attcttggac tcagctatgc      660



taatttgcaa acaggttctg gagttcttaa tgatagtttg tctggtggaa tgcagttgct      720



tccagatcct ttatattctc ttcctactga taatacttac cttttaacaa taacttccac      780



tgataatggc agaattttct tggctggaaa ggatggctgt ttatatgaag tagcctacca      840



ggctgaagca gggtggttta gccaaagatg taggaaaata aaccactcaa agagctcact      900



ttctttcctt gttccttcct tgctacaatt cacgttctca gaagatgatc ctattcttca      960



aattgcaatt gataattcta gaaatatttt atatacacga tctgagaaag gagtaataca     1020



ggtgtatgat ttgggacaag atggacaagg aatgagcaga gttgcctctg tgtcacagaa     1080



tgccattgtc tctgctgctg gtaacattgc taggaccatc gatcgttctg tttttaaacc     1140



aattgtccaa atagcagtga ttgaaaattc tgaatcactg gactgtcagt tattggctgt     1200



cacacatgca ggtgttaggt tatattttag cacttgtcca ttcagacagc cattagcacg     1260



gcctaataca ctgacgctgg ttcatgtccg cttacctcct ggattctcag catcttcaac     1320



cgtggaaaag ccttcaaaag tacatagagc tctttatagt aaaggtattc tattgatggc     1380



agcctcagaa aatgaggata atgatatttt atggtgtgtc aaccatgata cttttccttt     1440



ccaaaagcca atgatggaaa cccagatgac agctggtgtt gatggtcatt cctgggctct     1500



ttctgcgata gatgaattga aagtagataa aataattaca cctttaaaca aggatcatat     1560



tccaataact gattcaccag ttgttgtaca gcagcacatg ttacctccga agaaatttgt     1620



tctcctctca gcacagggga gccttatgtt tcataaactt agacctgtag atcaactgag     1680



gcatctactt gtgagtaatg tgggaggaga tggagaagag attgaaagat tctttaaatt     1740



acatcaggaa gaccaggctt gtgcaacttg ccttattctt gcttgctcca ctgctgcctg     1800



tgatagagaa gtatctgcct gggctactcg ggctttcttt aggtatggtg gtgaagcaca     1860



gatgagattt ccaaccactc ttccgcctcc aagtaatgtt ggtcccatct tggggtctcc     1920



tgtctattct agttctcctg ttcctagtgg tagtccctat ccaaatccat cctttttggg     1980



aacaccgtct catggtatac agcctcctgc catgtcaact ccagtgtgtg ctctgggaaa     2040



cccagcaact caggccacaa atatgagttg tgtgactgga ccagagattg tgtactctgg     2100



aaaacacaat ggtatttgca tttacttttc tcggatcatg ggaaacattt gggatgcaag     2160



cttagttgtg gagagaatat tcaagagtgg caacagagag atcactgcaa ttgaaagtag     2220



tgttccctgc caactgctag agtcagtgct acaagaacta aagggtttgc aggaatttct     2280



agacagaaac tcccagtttg caggaggacc attaggaaat ccaaatacta ctgctaaagt     2340



gcagcagagg ctgataggat tcatgcgtcc tgaaaacgga aatccccagc aaatgcaaca     2400



ggaactgcag aggaagtttc atgaggctca actaagtgaa aagatttcac ttcaggcaat     2460



tcagcagttg gttcgaaaat catatcaggc tctggcttta tggaaacttc tttgtgaaca     2520



tcaattcact atcattgtgg cagaacttca gaaggaactt caagagcagc tgaagatcac     2580



cacctttaaa gatcttgtaa tcagggacaa agaactcaca ggggcattaa ttgcttctct     2640



tatcaactgc tacatcagag ataatgccgc tgttgatggc attagtttac atttacagga     2700



tatctgccca cttctatata gcactgatga tgcaatttgt tctaaggcaa atgagcttct     2760



ccagcgttcc cgacaagttc aaaataagac tgaaaaagaa agaatgttaa gggaatcatt     2820



aaaggaatat caaaaaatta gcaatcaagt ggacctttcc aatgtttgtg ctcagtatag     2880



acaagtgaga ttttatgagg gtgtggtgga actttctctt acggctgcag agaaaaaaga     2940



tcctcaaggt cttgggcttc atttctataa acatggagaa ccagaagaag acatagttgg     3000



acttcaggcc ttccaagaaa gattaaacag ttacaaatgc attacagaca cacttcaaga     3060



actggtaaat caaagtaagg ccgctcctca gtctcccagt gtacccaaaa aacctggtcc     3120



tccagtgttg tcatctgatc caaatatgct gagtaatgaa gaagcaggac atcattttga     3180



acaaatgctt aaattgtcac agcgatccaa ggatgagctc tttagtattg ccctttataa     3240



ttggctaata caagtcgacc ttgcagataa gctgctacag gttgcttctc catttctgga     3300



gccacatcta gtccgaatgg ccaaagttga tcaaaacaga gttcgttata tggatttact     3360



ctggcggtat tacgagaaga acagaagttt cagtaatgct gctcgtgtac tgtccagact     3420



ggctgacatg catagcacag aaatttcact tcagcagcga ctagagtaca ttgctcgagc     3480



cattcttagt gccaaaagtt ccactgccat ttcatcaata gctgccgatg gtgaatttct     3540



tcatgaatta gaagaaaaaa tggaggttgc taggatccaa cttcagatac aggagacact     3600



acaaaggcag tattcccatc attcttctgt acaggatgca gtttctcagc tggattctga     3660



gctgatggac ataactaagc tttatgggga atttgctgac ccatttaaac ttgcagagtg     3720



caaacttgca ataattcatt gtgccggtta ttcagaccct atattggtgc agacactttg     3780



gcaagatatc atagagaaag aattgagtga cagtgtgaca ttgagctcct cggatagaat     3840



gcatgctctt agtctcaaga ttgttctcct tggcaaaatt tatgctggca caccacgctt     3900



ctttccttta gattttattg tacagttttt agaacagcag gtttgtactt tgaactggga     3960



tgtgggcttc gtaatacaga caatgaatga aattggagta ccattaccta gactactaga     4020



agtttatgat cagttgttca aatcacggga tccattctgg aacagaatga agaagccact     4080



gcaccttttg gattgtatac atgtattatt gataagatat gttgagaatc ccagccaagt     4140



tttaaattgt gaaaggagaa gatttacaaa tctctgcctg gatgctgttt gtggttacct     4200



tgttgagctc cagtctatga gctcgtcagt agcagtacaa gccatcactg ggaattttaa     4260



atctcttcaa gctaaattag aacggcttca ttaattactg tgatatactt tcatccgttt     4320



tatgatctgt aaaataaaaa ctcagctggg tccag                                4355





<210>  199

<211>  1391

<212>  PRT

<213>  Homo sapiens



<400>  199



Met Pro Ser Ser Leu Leu Gly Ala Ala Met Pro Ala Ser Thr Ser Ala 

1               5                   10                  15      





Ala Ala Leu Gln Glu Ala Leu Glu Asn Ala Gly Arg Leu Ile Asp Arg 

            20                  25                  30          





Gln Leu Gln Glu Asp Arg Met Tyr Pro Asp Leu Ser Glu Leu Leu Met 

        35                  40                  45              





Val Ser Ala Pro Asn Asn Pro Thr Val Ser Gly Met Ser Asp Met Asp 

    50                  55                  60                  





Tyr Pro Leu Gln Gly Pro Gly Leu Leu Ser Val Pro Asn Leu Pro Glu 

65                  70                  75                  80  





Ile Ser Ser Ile Arg Arg Val Pro Leu Pro Pro Glu Leu Val Glu Gln 

                85                  90                  95      





Phe Gly His Met Gln Cys Asn Cys Met Met Gly Val Phe Pro Pro Ile 

            100                 105                 110         





Ser Arg Ala Trp Leu Thr Ile Asp Ser Asp Ile Phe Met Trp Asn Tyr 

        115                 120                 125             





Glu Asp Gly Gly Asp Leu Ala Tyr Phe Asp Gly Leu Ser Glu Thr Ile 

    130                 135                 140                 





Leu Ala Val Gly Leu Val Lys Pro Lys Ala Gly Ile Phe Gln Pro His 

145                 150                 155                 160 





Val Arg His Leu Leu Val Leu Ala Thr Pro Val Asp Ile Val Ile Leu 

                165                 170                 175     





Gly Leu Ser Tyr Ala Asn Leu Gln Thr Gly Ser Gly Val Leu Asn Asp 

            180                 185                 190         





Ser Leu Ser Gly Gly Met Gln Leu Leu Pro Asp Pro Leu Tyr Ser Leu 

        195                 200                 205             





Pro Thr Asp Asn Thr Tyr Leu Leu Thr Ile Thr Ser Thr Asp Asn Gly 

    210                 215                 220                 





Arg Ile Phe Leu Ala Gly Lys Asp Gly Cys Leu Tyr Glu Val Ala Tyr 

225                 230                 235                 240 





Gln Ala Glu Ala Gly Trp Phe Ser Gln Arg Cys Arg Lys Ile Asn His 

                245                 250                 255     





Ser Lys Ser Ser Leu Ser Phe Leu Val Pro Ser Leu Leu Gln Phe Thr 

            260                 265                 270         





Phe Ser Glu Asp Asp Pro Ile Leu Gln Ile Ala Ile Asp Asn Ser Arg 

        275                 280                 285             





Asn Ile Leu Tyr Thr Arg Ser Glu Lys Gly Val Ile Gln Val Tyr Asp 

    290                 295                 300                 





Leu Gly Gln Asp Gly Gln Gly Met Ser Arg Val Ala Ser Val Ser Gln 

305                 310                 315                 320 





Asn Ala Ile Val Ser Ala Ala Gly Asn Ile Ala Arg Thr Ile Asp Arg 

                325                 330                 335     





Ser Val Phe Lys Pro Ile Val Gln Ile Ala Val Ile Glu Asn Ser Glu 

            340                 345                 350         





Ser Leu Asp Cys Gln Leu Leu Ala Val Thr His Ala Gly Val Arg Leu 

        355                 360                 365             





Tyr Phe Ser Thr Cys Pro Phe Arg Gln Pro Leu Ala Arg Pro Asn Thr 

    370                 375                 380                 





Leu Thr Leu Val His Val Arg Leu Pro Pro Gly Phe Ser Ala Ser Ser 

385                 390                 395                 400 





Thr Val Glu Lys Pro Ser Lys Val His Arg Ala Leu Tyr Ser Lys Gly 

                405                 410                 415     





Ile Leu Leu Met Ala Ala Ser Glu Asn Glu Asp Asn Asp Ile Leu Trp 

            420                 425                 430         





Cys Val Asn His Asp Thr Phe Pro Phe Gln Lys Pro Met Met Glu Thr 

        435                 440                 445             





Gln Met Thr Ala Gly Val Asp Gly His Ser Trp Ala Leu Ser Ala Ile 

    450                 455                 460                 





Asp Glu Leu Lys Val Asp Lys Ile Ile Thr Pro Leu Asn Lys Asp His 

465                 470                 475                 480 





Ile Pro Ile Thr Asp Ser Pro Val Val Val Gln Gln His Met Leu Pro 

                485                 490                 495     





Pro Lys Lys Phe Val Leu Leu Ser Ala Gln Gly Ser Leu Met Phe His 

            500                 505                 510         





Lys Leu Arg Pro Val Asp Gln Leu Arg His Leu Leu Val Ser Asn Val 

        515                 520                 525             





Gly Gly Asp Gly Glu Glu Ile Glu Arg Phe Phe Lys Leu His Gln Glu 

    530                 535                 540                 





Asp Gln Ala Cys Ala Thr Cys Leu Ile Leu Ala Cys Ser Thr Ala Ala 

545                 550                 555                 560 





Cys Asp Arg Glu Val Ser Ala Trp Ala Thr Arg Ala Phe Phe Arg Tyr 

                565                 570                 575     





Gly Gly Glu Ala Gln Met Arg Phe Pro Thr Thr Leu Pro Pro Pro Ser 

            580                 585                 590         





Asn Val Gly Pro Ile Leu Gly Ser Pro Val Tyr Ser Ser Ser Pro Val 

        595                 600                 605             





Pro Ser Gly Ser Pro Tyr Pro Asn Pro Ser Phe Leu Gly Thr Pro Ser 

    610                 615                 620                 





His Gly Ile Gln Pro Pro Ala Met Ser Thr Pro Val Cys Ala Leu Gly 

625                 630                 635                 640 





Asn Pro Ala Thr Gln Ala Thr Asn Met Ser Cys Val Thr Gly Pro Glu 

                645                 650                 655     





Ile Val Tyr Ser Gly Lys His Asn Gly Ile Cys Ile Tyr Phe Ser Arg 

            660                 665                 670         





Ile Met Gly Asn Ile Trp Asp Ala Ser Leu Val Val Glu Arg Ile Phe 

        675                 680                 685             





Lys Ser Gly Asn Arg Glu Ile Thr Ala Ile Glu Ser Ser Val Pro Cys 

    690                 695                 700                 





Gln Leu Leu Glu Ser Val Leu Gln Glu Leu Lys Gly Leu Gln Glu Phe 

705                 710                 715                 720 





Leu Asp Arg Asn Ser Gln Phe Ala Gly Gly Pro Leu Gly Asn Pro Asn 

                725                 730                 735     





Thr Thr Ala Lys Val Gln Gln Arg Leu Ile Gly Phe Met Arg Pro Glu 

            740                 745                 750         





Asn Gly Asn Pro Gln Gln Met Gln Gln Glu Leu Gln Arg Lys Phe His 

        755                 760                 765             





Glu Ala Gln Leu Ser Glu Lys Ile Ser Leu Gln Ala Ile Gln Gln Leu 

    770                 775                 780                 





Val Arg Lys Ser Tyr Gln Ala Leu Ala Leu Trp Lys Leu Leu Cys Glu 

785                 790                 795                 800 





His Gln Phe Thr Ile Ile Val Ala Glu Leu Gln Lys Glu Leu Gln Glu 

                805                 810                 815     





Gln Leu Lys Ile Thr Thr Phe Lys Asp Leu Val Ile Arg Asp Lys Glu 

            820                 825                 830         





Leu Thr Gly Ala Leu Ile Ala Ser Leu Ile Asn Cys Tyr Ile Arg Asp 

        835                 840                 845             





Asn Ala Ala Val Asp Gly Ile Ser Leu His Leu Gln Asp Ile Cys Pro 

    850                 855                 860                 





Leu Leu Tyr Ser Thr Asp Asp Ala Ile Cys Ser Lys Ala Asn Glu Leu 

865                 870                 875                 880 





Leu Gln Arg Ser Arg Gln Val Gln Asn Lys Thr Glu Lys Glu Arg Met 

                885                 890                 895     





Leu Arg Glu Ser Leu Lys Glu Tyr Gln Lys Ile Ser Asn Gln Val Asp 

            900                 905                 910         





Leu Ser Asn Val Cys Ala Gln Tyr Arg Gln Val Arg Phe Tyr Glu Gly 

        915                 920                 925             





Val Val Glu Leu Ser Leu Thr Ala Ala Glu Lys Lys Asp Pro Gln Gly 

    930                 935                 940                 





Leu Gly Leu His Phe Tyr Lys His Gly Glu Pro Glu Glu Asp Ile Val 

945                 950                 955                 960 





Gly Leu Gln Ala Phe Gln Glu Arg Leu Asn Ser Tyr Lys Cys Ile Thr 

                965                 970                 975     





Asp Thr Leu Gln Glu Leu Val Asn Gln Ser Lys Ala Ala Pro Gln Ser 

            980                 985                 990         





Pro Ser Val Pro Lys Lys Pro Gly  Pro Pro Val Leu Ser  Ser Asp Pro 

        995                 1000                 1005             





Asn Met  Leu Ser Asn Glu Glu  Ala Gly His His Phe  Glu Gln Met 

    1010                 1015                 1020             





Leu Lys  Leu Ser Gln Arg Ser  Lys Asp Glu Leu Phe  Ser Ile Ala 

    1025                 1030                 1035             





Leu Tyr  Asn Trp Leu Ile Gln  Val Asp Leu Ala Asp  Lys Leu Leu 

    1040                 1045                 1050             





Gln Val  Ala Ser Pro Phe Leu  Glu Pro His Leu Val  Arg Met Ala 

    1055                 1060                 1065             





Lys Val  Asp Gln Asn Arg Val  Arg Tyr Met Asp Leu  Leu Trp Arg 

    1070                 1075                 1080             





Tyr Tyr  Glu Lys Asn Arg Ser  Phe Ser Asn Ala Ala  Arg Val Leu 

    1085                 1090                 1095             





Ser Arg  Leu Ala Asp Met His  Ser Thr Glu Ile Ser  Leu Gln Gln 

    1100                 1105                 1110             





Arg Leu  Glu Tyr Ile Ala Arg  Ala Ile Leu Ser Ala  Lys Ser Ser 

    1115                 1120                 1125             





Thr Ala  Ile Ser Ser Ile Ala  Ala Asp Gly Glu Phe  Leu His Glu 

    1130                 1135                 1140             





Leu Glu  Glu Lys Met Glu Val  Ala Arg Ile Gln Leu  Gln Ile Gln 

    1145                 1150                 1155             





Glu Thr  Leu Gln Arg Gln Tyr  Ser His His Ser Ser  Val Gln Asp 

    1160                 1165                 1170             





Ala Val  Ser Gln Leu Asp Ser  Glu Leu Met Asp Ile  Thr Lys Leu 

    1175                 1180                 1185             





Tyr Gly  Glu Phe Ala Asp Pro  Phe Lys Leu Ala Glu  Cys Lys Leu 

    1190                 1195                 1200             





Ala Ile  Ile His Cys Ala Gly  Tyr Ser Asp Pro Ile  Leu Val Gln 

    1205                 1210                 1215             





Thr Leu  Trp Gln Asp Ile Ile  Glu Lys Glu Leu Ser  Asp Ser Val 

    1220                 1225                 1230             





Thr Leu  Ser Ser Ser Asp Arg  Met His Ala Leu Ser  Leu Lys Ile 

    1235                 1240                 1245             





Val Leu  Leu Gly Lys Ile Tyr  Ala Gly Thr Pro Arg  Phe Phe Pro 

    1250                 1255                 1260             





Leu Asp  Phe Ile Val Gln Phe  Leu Glu Gln Gln Val  Cys Thr Leu 

    1265                 1270                 1275             





Asn Trp  Asp Val Gly Phe Val  Ile Gln Thr Met Asn  Glu Ile Gly 

    1280                 1285                 1290             





Val Pro  Leu Pro Arg Leu Leu  Glu Val Tyr Asp Gln  Leu Phe Lys 

    1295                 1300                 1305             





Ser Arg  Asp Pro Phe Trp Asn  Arg Met Lys Lys Pro  Leu His Leu 

    1310                 1315                 1320             





Leu Asp  Cys Ile His Val Leu  Leu Ile Arg Tyr Val  Glu Asn Pro 

    1325                 1330                 1335             





Ser Gln  Val Leu Asn Cys Glu  Arg Arg Arg Phe Thr  Asn Leu Cys 

    1340                 1345                 1350             





Leu Asp  Ala Val Cys Gly Tyr  Leu Val Glu Leu Gln  Ser Met Ser 

    1355                 1360                 1365             





Ser Ser  Val Ala Val Gln Ala  Ile Thr Gly Asn Phe  Lys Ser Leu 

    1370                 1375                 1380             





Gln Ala  Lys Leu Glu Arg Leu  His 

    1385                 1390     





<210>  200

<211>  2311

<212>  DNA

<213>  Homo sapiens



<400>  200

cggtactctg agtgcagtca gtcctcggcg ctgttttccc tgatttgctg tcgacgccag       60



gaaggaagga cgcgtgcaga ggaccgcaga ggggtggccg tggctgagag gagacagcgc      120



cgcagcactg agggtttggg cttgcaggcg ctgcaggaga cgcccaggcg gagtcttgtc      180



tcgcagccag ctctgagcgg gaggcctgag cgggaagcat tggcgtccga gcgacttcta      240



ggagcctggg gttcggcgct atggaggagc tcgatggcga gccaacagtc actttgattc      300



caggcgtgaa ttccaagaag aaccaaatgt attttgactg gggtccaggg gagatgctgg      360



tatgtgaaac ctccttcaac aaaaaagaaa aatcagagat ggtgccaagt tgccccttta      420



tctatatcat ccgtaaggat gtagatgttt actctcaaat cttgagaaaa ctcttcaatg      480



aatcccatgg aatctttctg ggcctccaga gaattgacga agagttgact ggaaaatcca      540



gaaaatctca attggttcga gtgagtaaaa actaccgatc agtcatcaga gcatgtatgg      600



aggaaatgca ccaggttgca attgctgcta aagatccagc caatggccgc cagttcagca      660



gccaggtctc cattttgtca gcaatggagc tcatctggaa cctgtgtgag attcttttta      720



ttgaagtggc cccagctggc cctctcctcc tccatctcct tgactgggtc cggctccatg      780



tgtgcgaggt ggacagtttg tcggcagatg ttctgggcag tgagaatcca agcaaacatg      840



acagcttctg gaacttggtg accatcttgg tgctgcaggg ccggctggat gaggcccgac      900



agatgctctc caaggaagcc gatgccagcc ccgcctctgc aggcatatgc cgaatcatgg      960



gggacctgat gaggacaatg cccattctta gtcctgggaa cacccagaca ctgacagagc     1020



tggagctgaa gtggcagcac tggcacgagg aatgtgagcg gtacctccag gacagcacat     1080



tcgccaccag ccctcacctg gagtctctct tgaagattat gctgggagac gaagctgcct     1140



tgttagagca gaaggaactt ctgagtaatt ggtatcattt cctagtgact cggctcttgt     1200



actccaatcc cacagtaaaa cccattgatc tgcactacta tgcccagtcc agcctggacc     1260



tgtttctggg aggtgagagc agcccagaac ccctggacaa catcttgttg gcagcctttg     1320



agtttgacat ccatcaagta atcaaagagt gcagcatcgc cctgagcaac tggtggtttg     1380



tggcccacct gacagacctg ctggaccact gcaagctcct ccagtcacac aacctctatt     1440



tcggttccaa catgagagag ttcctcctgc tggagtacgc ctcgggactg tttgctcatc     1500



ccagcctgtg gcagctgggg gtcgattact ttgattactg ccccgagctg ggccgagtct     1560



ccctggagct gcacattgag cggatacctc tgaacaccga gcagaaagcc ctgaaggtgc     1620



tgcggatctg tgagcagcgg cagatgactg aacaagttcg cagcatttgt aagatcttag     1680



ccatgaaagc cgtccgcaac aatcgcctgg gttctgccct ctcttggagc atccgtgcta     1740



aggatgccgc ctttgccacg ctcgtgtcag acaggttcct cagggattac tgtgagcgag     1800



gctgcttttc tgatttggat ctcattgaca acctggggcc agccatgatg ctcagtgacc     1860



gactgacatt cctgggaaag tatcgcgagt tccaccgtat gtacggggag aagcgttttg     1920



ccgacgcagc ttctctcctt ctgtccttga tgacgtctcg gattgcccct cggtctttct     1980



ggatgactct gctgacagac gccttgcccc ttttggaaca gaaacaggtg attttctcag     2040



cagaacagac ttatgagttg atgcggtgtc tggaggactt gacgtcaaga agacctgtgc     2100



atggagaatc tgataccgag cagctccagg atgatgacat agagaccacc aaggtggaaa     2160



tgctgagact ttctctggca cgaaatcttg ctcgggcaat tataagagaa ggctcactgg     2220



aaggttcctg agaactgctt caatgtggta tctttgtatg gcaatgtata tagatttttt     2280



taaaagaata aatgttgttt tgcaaatgta g                                    2311





<210>  201

<211>  656

<212>  PRT

<213>  Homo sapiens



<400>  201



Met Glu Glu Leu Asp Gly Glu Pro Thr Val Thr Leu Ile Pro Gly Val 

1               5                   10                  15      





Asn Ser Lys Lys Asn Gln Met Tyr Phe Asp Trp Gly Pro Gly Glu Met 

            20                  25                  30          





Leu Val Cys Glu Thr Ser Phe Asn Lys Lys Glu Lys Ser Glu Met Val 

        35                  40                  45              





Pro Ser Cys Pro Phe Ile Tyr Ile Ile Arg Lys Asp Val Asp Val Tyr 

    50                  55                  60                  





Ser Gln Ile Leu Arg Lys Leu Phe Asn Glu Ser His Gly Ile Phe Leu 

65                  70                  75                  80  





Gly Leu Gln Arg Ile Asp Glu Glu Leu Thr Gly Lys Ser Arg Lys Ser 

                85                  90                  95      





Gln Leu Val Arg Val Ser Lys Asn Tyr Arg Ser Val Ile Arg Ala Cys 

            100                 105                 110         





Met Glu Glu Met His Gln Val Ala Ile Ala Ala Lys Asp Pro Ala Asn 

        115                 120                 125             





Gly Arg Gln Phe Ser Ser Gln Val Ser Ile Leu Ser Ala Met Glu Leu 

    130                 135                 140                 





Ile Trp Asn Leu Cys Glu Ile Leu Phe Ile Glu Val Ala Pro Ala Gly 

145                 150                 155                 160 





Pro Leu Leu Leu His Leu Leu Asp Trp Val Arg Leu His Val Cys Glu 

                165                 170                 175     





Val Asp Ser Leu Ser Ala Asp Val Leu Gly Ser Glu Asn Pro Ser Lys 

            180                 185                 190         





His Asp Ser Phe Trp Asn Leu Val Thr Ile Leu Val Leu Gln Gly Arg 

        195                 200                 205             





Leu Asp Glu Ala Arg Gln Met Leu Ser Lys Glu Ala Asp Ala Ser Pro 

    210                 215                 220                 





Ala Ser Ala Gly Ile Cys Arg Ile Met Gly Asp Leu Met Arg Thr Met 

225                 230                 235                 240 





Pro Ile Leu Ser Pro Gly Asn Thr Gln Thr Leu Thr Glu Leu Glu Leu 

                245                 250                 255     





Lys Trp Gln His Trp His Glu Glu Cys Glu Arg Tyr Leu Gln Asp Ser 

            260                 265                 270         





Thr Phe Ala Thr Ser Pro His Leu Glu Ser Leu Leu Lys Ile Met Leu 

        275                 280                 285             





Gly Asp Glu Ala Ala Leu Leu Glu Gln Lys Glu Leu Leu Ser Asn Trp 

    290                 295                 300                 





Tyr His Phe Leu Val Thr Arg Leu Leu Tyr Ser Asn Pro Thr Val Lys 

305                 310                 315                 320 





Pro Ile Asp Leu His Tyr Tyr Ala Gln Ser Ser Leu Asp Leu Phe Leu 

                325                 330                 335     





Gly Gly Glu Ser Ser Pro Glu Pro Leu Asp Asn Ile Leu Leu Ala Ala 

            340                 345                 350         





Phe Glu Phe Asp Ile His Gln Val Ile Lys Glu Cys Ser Ile Ala Leu 

        355                 360                 365             





Ser Asn Trp Trp Phe Val Ala His Leu Thr Asp Leu Leu Asp His Cys 

    370                 375                 380                 





Lys Leu Leu Gln Ser His Asn Leu Tyr Phe Gly Ser Asn Met Arg Glu 

385                 390                 395                 400 





Phe Leu Leu Leu Glu Tyr Ala Ser Gly Leu Phe Ala His Pro Ser Leu 

                405                 410                 415     





Trp Gln Leu Gly Val Asp Tyr Phe Asp Tyr Cys Pro Glu Leu Gly Arg 

            420                 425                 430         





Val Ser Leu Glu Leu His Ile Glu Arg Ile Pro Leu Asn Thr Glu Gln 

        435                 440                 445             





Lys Ala Leu Lys Val Leu Arg Ile Cys Glu Gln Arg Gln Met Thr Glu 

    450                 455                 460                 





Gln Val Arg Ser Ile Cys Lys Ile Leu Ala Met Lys Ala Val Arg Asn 

465                 470                 475                 480 





Asn Arg Leu Gly Ser Ala Leu Ser Trp Ser Ile Arg Ala Lys Asp Ala 

                485                 490                 495     





Ala Phe Ala Thr Leu Val Ser Asp Arg Phe Leu Arg Asp Tyr Cys Glu 

            500                 505                 510         





Arg Gly Cys Phe Ser Asp Leu Asp Leu Ile Asp Asn Leu Gly Pro Ala 

        515                 520                 525             





Met Met Leu Ser Asp Arg Leu Thr Phe Leu Gly Lys Tyr Arg Glu Phe 

    530                 535                 540                 





His Arg Met Tyr Gly Glu Lys Arg Phe Ala Asp Ala Ala Ser Leu Leu 

545                 550                 555                 560 





Leu Ser Leu Met Thr Ser Arg Ile Ala Pro Arg Ser Phe Trp Met Thr 

                565                 570                 575     





Leu Leu Thr Asp Ala Leu Pro Leu Leu Glu Gln Lys Gln Val Ile Phe 

            580                 585                 590         





Ser Ala Glu Gln Thr Tyr Glu Leu Met Arg Cys Leu Glu Asp Leu Thr 

        595                 600                 605             





Ser Arg Arg Pro Val His Gly Glu Ser Asp Thr Glu Gln Leu Gln Asp 

    610                 615                 620                 





Asp Asp Ile Glu Thr Thr Lys Val Glu Met Leu Arg Leu Ser Leu Ala 

625                 630                 635                 640 





Arg Asn Leu Ala Arg Ala Ile Ile Arg Glu Gly Ser Leu Glu Gly Ser 

                645                 650                 655     





<210>  202

<211>  6523

<212>  DNA

<213>  Homo sapiens



<400>  202

gctgcgtagt cgtcgccggg ctccgttgcc cgcgctgttt taccttccca acgcttgagg       60



cggacgctgg ggggtcctgc gcctttccct cctgccgctg gggactgcag gctaaggcca      120



tgtcccgaaa gcaggcggcg aagagccggc cgggcagcgg cagccggaaa gccgaggccg      180



agcgcaagcg ggacgagcgg gcggcgcgcc gggccctggc caaggagcgg cggaatcggc      240



cggagtctgg cggcggcggc ggctgcgagg aggagttcgt cagcttcgcc aaccagctgc      300



aggccctggg gctgaagctg cgggaggtgc cgggggacgg caattgcttg ttcagagctc      360



ttggtgatca attggaggga cactcacgaa atcatctcaa gcacagacag gagacagtgg      420



actacatgat aaagcagcgg gaagattttg aaccctttgt agaagatgac attccttttg      480



agaagcatgt ggccagtttg gcaaagcctg gtacttttgc tggcaatgat gcaattgtag      540



cctttgcaag aaatcatcag ttgaatgtag tgattcatca acttaatgcc cctttgtggc      600



agattcgtgg tacagagaaa agcagcgtga gggagttaca catcgcatat cggtatggag      660



agcactacga cagtgttcgg aggatcaatg acaactcaga ggcacctgca catctccaga      720



cggattttca gatgcttcat caagatgaat caaataaaag agaaaagatc aagacaaagg      780



gaatggactc tgaagacgac ctgagagatg aagtagagga tgctgtccag aaagtttgta      840



atgcaactgg atgttcagat tttaatttaa tagtccagaa cctggaagct gaaaattata      900



atattgaatc tgcaataatt gccgtgcttc ggatgaacca agggaagaga aataatgcag      960



aagagaatct tgagcccagt ggtcgagtgc tgaagcagtg tggccctttg tgggaggagg     1020



gtggcagtgg tgccagaatc tttggaaatc agggcttaaa tgaaggcagg accgaaaaca     1080



ataaggcaca ggccagccct agtgaagaaa acaaagcaaa taaaaaccag ctcgcaaagg     1140



tcacaaacaa acagaggcga gaacagcagt ggatggagaa gaagaagcgg caggaggaga     1200



ggcaccgcca caaagccctg gagagcagag gtagccacag ggacaataac agaagcgaag     1260



cagaggcgaa cacgcaggtc accttggtga agaccttcgc cgctctcaac atctgactct     1320



ttggcctctt gggagttgta agaagcggct ggaaaaggat tgctgtgtgc tagactttcc     1380



agtgaggccg tccttttata aaacgcaaca caaccaacga agcccacaca tgagctcaca     1440



cactgagtta gtttcgttca agctgcctct ttttttgttc gaagttttat tagtgatatg     1500



ttggtgtttt atgaaaatgc agtgaggcca ttcatattct gtaatacaaa attaaaatac     1560



tgagttttag gggcagatag ttaggtcagg aaaaaccttt taagtggtgg ctttatttgc     1620



cctgaaaatc agacttcagt gaccctagga tctttcctta acatttgggg tgagttttgc     1680



tgtaattgtt catgagtagt ttagaataat tgttagaaat tcagaatgac aagtttcctt     1740



agtttctctt tcattctcaa acagatatat agggtagctt ataaatgatc tccaactcag     1800



gaatatgctt tgatttactt ctaatccaag ttactcagaa aataattcag gaattgtttt     1860



cccaaagtta cgtgagggtt gtggcctgca gtcaggatgg aaattaaccg catttctctc     1920



cttcctgatt ctgatgttat ttcagatggg atgcaggtgc tgttagttca tttgcactca     1980



agccatatga taaatgcagc tgactgttaa ttaggcctgg ccttgttggg aagttgatag     2040



tggtgttggg tttttggtat ttgtttcctg acagtgggga gatggcatgt tactgcttgt     2100



gatacagttc tggaattctg atagtgtgta gagcagggtc tatagttgta acaggagacg     2160



aactcctggg gttttgccta agaggagtct aaagaattat gtttttatag gagaagcctg     2220



gaagaataag gtttttcatg ttcgcatttt aaataacgat tttcttccct tctgttgtag     2280



acttagatgc cttcagagag atacgtggta acttgacctt ataggtcgct aaacttagta     2340



ttgtggaaat taaatcttat aaaatgctac atttatttct ttttatttaa gccctgtttg     2400



gcatttcaaa gttgggaaaa ctccagcatc tgctggaagt tgttggacca gcagggttgg     2460



ttgacttagg ttggaccagc agagaagaga acatactttg gttgaggcct tcgaatcact     2520



cttcagttct gaaatagaca gacttgagca gtggagagac gtctttccta aaactgagtt     2580



aggtggatgt gaacttaaga actataacgt atgaggcagc ccatcttgga tcatctttgt     2640



cttttgggac ctaatacttg ggcaaataat tgatgctgag ttgaaaggta aattattagt     2700



tatcttcccc acccctcgca tttcagaatt ataaaaattc ggaggcaaat tgaaaactaa     2760



aatgtttggt aggccctgga gtcgccagat tgtctttatc accaggcctt tggctttctt     2820



cagtttcact ggtatctttt ggttttgttt ttgactttgg tggctttttg tagttggagc     2880



atcagtagtc tcttggaatt gctcctagga cattgtggtt taggtttctt cctgggtaca     2940



gtacattgta aaatttagca gattaaaaaa agtacacagc attttttttc tgtgcacgtc     3000



gcagagtcct gagcttgagg ctgtgttact ctactcattc caaacgaatg aaagatctct     3060



gttgccttac tctaaggaag tgggatcgag tgcgttagga tctatggttg tcttggtttt     3120



caactctggg cagattcctg actggctgag tgtttctgaa tgaagatgtt ttcctgtctg     3180



ttttgtactg cttgagtgca gaggccagat cctctcagaa agataagatt gtatgccaga     3240



aattcagatt agcagtcagc ttaagagaga cttattgtca gaagtagtag aattgcttta     3300



tttacttggt taatgaaggt ggccttgggc cctattgggt tttagaagtt ttagaagctg     3360



ctaaaaagtt attaaagaat attgggaaca tttatttttt aaattaccta attctggtaa     3420



taggcttcag catttctgga gtataataat ggtggtttaa aaaactaatc aaacggcttt     3480



agtaatttta ctactggttt cacagctttt cagttacagt tggtctgttt agtgtgttaa     3540



ttattaggaa tcgggtacat gcatccaact tcagtgatac cttctagcta atggtttcaa     3600



tttagacttc actgcctcag tctcactggg tacatgagaa ggttggaatc aacatgctta     3660



gttgcctcag tgggcacttg aaaattcctt cactggcagc ccgagtggag gcccagtatg     3720



tctagtcctg ggatgactgt tgtcagcagc tgttactcta gtacaggtgc tcctgtgaac     3780



tctttattag gaactgaatg tgtcttaacc tctgtgttac atcttggctg gcagagattt     3840



atgttacatg agattgtctt ggtagcttgt agtgtggtca ggagaaaggg gatggagcag     3900



tggtgcatag ctgcttactg ctcttataaa cggtatataa aggttttacg gattttgaaa     3960



atattttttt ttagaggtca aaataaatac cattttagtg gcaacagctt tgaactagag     4020



aggtagatgt attaaagcag catagaacca taacttctag ataatgtagt tgccactagg     4080



agatattaga aagttagaat gtatgtgtgt atttagtttt tcaataataa tgaacataca     4140



ctttcaggag caaagtatgg ttgagaaatt gtggcagaaa gaattttaaa tgttagtcga     4200



agttgtctgt agtttcttta ttaagctctg aaaacacttc caatgccagt ttgattctga     4260



gggcttggga agtgggatct cccttgtgga gcagctggag ctggctggga gggagcctct     4320



ccatgggtaa tttattatgc ctgccctgct tcccccaggg agctgcttca gtgtgaaatg     4380



atgtgattgt cgggggtggg gtgggaggag ggccaccttc agtcggggag ttgctcacat     4440



attacacagg tagcatcagg tggacttcag cgctgaactg tactagtagt gagtccctgt     4500



agtcaatgtg caatttctct aattctgaga aactctgtag actctgcctg ggttttactg     4560



ggtcagcata gaatgctatc agtttacctc tgtgaaatat tcagtcagtt gaaggaaact     4620



tggattccta gtcagaggtg actaaaagtt accctgacca aaaggatctc tgcgggggga     4680



agagaatgga gcttcctgat tttaatgtgt tgcgtcagtg gccctcttcg actcccgttt     4740



tgggtagatg cgtagctctt cactttctta cctcaaggct ctgtctagcc atgttaaatc     4800



tttagactca gtctgatgcc gtttttctgt tttgccattc tcattattca cagctttcag     4860



aacaagtgtt gctaaaactc cggggccttt gacagttgtt ctgaggtgat ttaataatgg     4920



actttttata agttatgttt tcctggctct aaagtaaatt tttttttttt tttttttgag     4980



acagagtctt gctttgttgc ccaggctgga gtgtggtggg gcaatctcgg ctcactgcaa     5040



cctccacctc ccgggttcaa gcgattctcc tgcctcagcc tcctgagtag ctgggattac     5100



aggtgtgtgc caccatgctt ggctaatttt tgtattttta gtagagacgg ggtttcacca     5160



tgttagccag gctggtctca aactcctgac cttgtgatct gcccgcctca gcctcccaaa     5220



gtgctaggat tacgggtgtg agcaaccctg cccggccagt aaattgtatt tttttaatga     5280



catcattgat ttgaagatct agatggcata aattacgacg tctgccatcg catattagaa     5340



aggggacagt catatttgta acgtggagag aacacggagc accagtcacc acgtgcactt     5400



aggatgcaga gcttaccgca caccgctgat ggggacctcc ggaaagagcg gtgccttgtg     5460



gttggcctgg aagttctctc ccaaggtgaa attcctttaa aacctcaggc tctgacctat     5520



gtctttgaag cagctgcttt gtagagtccc tctctttact gtcctcgtta ggactgtttt     5580



gtggttccat gaaaatgttt agcatccttg cagaattact tgagaagggg ctggtaccag     5640



tgtaaagaat ctatttctgt aaaactacga acttttgcat agggaattta ttctaagcag     5700



gtcatagccg tgatccagag ctgctgctgc tcactgccag tccttgcggc tggcggcgat     5760



tgccggacag actctctgtg gcctggctct catccttggc gtgtcagcct gcggcaggct     5820



gccagccatc catgacaatc atgtgagctc agccacagac ctcagctggc ggtttgatcc     5880



ctggcaggtc cctcgagcag tactggtaag aggcttcaca cattttccca ctcttacagt     5940



tcatttttca tagtaggaag ggcccttggc ctccccagtg cctcttccag agcctccacc     6000



agcactaagc tcagaggaaa gaagaaaagg gccaggagtc agacgtcaca cccgggggct     6060



cccctttccc atgtagaagt gttggcatgc gtcagtctcc tttacagagg ggtggatgta     6120



tccgtggagg aggggccttc tctctttcta attgcactat acttgttcta gcttcagtct     6180



ggagatactt aagacctcca tggggtcgtg atccatagac ttagcaagtc ttgccttatc     6240



tatggagctc gatggtgaga attgtgacca ttgtctgatg tccatagttc cttcccccta     6300



gattgtttct ttccacggat tgtgttcatc tgaaccattt tattttttat ttaccaaagt     6360



actgtacttg gctatttgca gtgttttcaa aaccaaatgt ttcttttttt gtgtttttaa     6420



tcttcgatac ttggtgcaat agaagctgca aagatgtgcc actttatcta tgaaatggag     6480



ttttgtatac caataaattc tagtttaaaa acaaaaaaaa aaa                       6523





<210>  203

<211>  398

<212>  PRT

<213>  Homo sapiens



<400>  203



Met Ser Arg Lys Gln Ala Ala Lys Ser Arg Pro Gly Ser Gly Ser Arg 

1               5                   10                  15      





Lys Ala Glu Ala Glu Arg Lys Arg Asp Glu Arg Ala Ala Arg Arg Ala 

            20                  25                  30          





Leu Ala Lys Glu Arg Arg Asn Arg Pro Glu Ser Gly Gly Gly Gly Gly 

        35                  40                  45              





Cys Glu Glu Glu Phe Val Ser Phe Ala Asn Gln Leu Gln Ala Leu Gly 

    50                  55                  60                  





Leu Lys Leu Arg Glu Val Pro Gly Asp Gly Asn Cys Leu Phe Arg Ala 

65                  70                  75                  80  





Leu Gly Asp Gln Leu Glu Gly His Ser Arg Asn His Leu Lys His Arg 

                85                  90                  95      





Gln Glu Thr Val Asp Tyr Met Ile Lys Gln Arg Glu Asp Phe Glu Pro 

            100                 105                 110         





Phe Val Glu Asp Asp Ile Pro Phe Glu Lys His Val Ala Ser Leu Ala 

        115                 120                 125             





Lys Pro Gly Thr Phe Ala Gly Asn Asp Ala Ile Val Ala Phe Ala Arg 

    130                 135                 140                 





Asn His Gln Leu Asn Val Val Ile His Gln Leu Asn Ala Pro Leu Trp 

145                 150                 155                 160 





Gln Ile Arg Gly Thr Glu Lys Ser Ser Val Arg Glu Leu His Ile Ala 

                165                 170                 175     





Tyr Arg Tyr Gly Glu His Tyr Asp Ser Val Arg Arg Ile Asn Asp Asn 

            180                 185                 190         





Ser Glu Ala Pro Ala His Leu Gln Thr Asp Phe Gln Met Leu His Gln 

        195                 200                 205             





Asp Glu Ser Asn Lys Arg Glu Lys Ile Lys Thr Lys Gly Met Asp Ser 

    210                 215                 220                 





Glu Asp Asp Leu Arg Asp Glu Val Glu Asp Ala Val Gln Lys Val Cys 

225                 230                 235                 240 





Asn Ala Thr Gly Cys Ser Asp Phe Asn Leu Ile Val Gln Asn Leu Glu 

                245                 250                 255     





Ala Glu Asn Tyr Asn Ile Glu Ser Ala Ile Ile Ala Val Leu Arg Met 

            260                 265                 270         





Asn Gln Gly Lys Arg Asn Asn Ala Glu Glu Asn Leu Glu Pro Ser Gly 

        275                 280                 285             





Arg Val Leu Lys Gln Cys Gly Pro Leu Trp Glu Glu Gly Gly Ser Gly 

    290                 295                 300                 





Ala Arg Ile Phe Gly Asn Gln Gly Leu Asn Glu Gly Arg Thr Glu Asn 

305                 310                 315                 320 





Asn Lys Ala Gln Ala Ser Pro Ser Glu Glu Asn Lys Ala Asn Lys Asn 

                325                 330                 335     





Gln Leu Ala Lys Val Thr Asn Lys Gln Arg Arg Glu Gln Gln Trp Met 

            340                 345                 350         





Glu Lys Lys Lys Arg Gln Glu Glu Arg His Arg His Lys Ala Leu Glu 

        355                 360                 365             





Ser Arg Gly Ser His Arg Asp Asn Asn Arg Ser Glu Ala Glu Ala Asn 

    370                 375                 380                 





Thr Gln Val Thr Leu Val Lys Thr Phe Ala Ala Leu Asn Ile 

385                 390                 395             





<210>  204

<211>  2525

<212>  DNA

<213>  Homo sapiens



<400>  204

ccgaagtgca ttatttcaca atctaaagct tgtatatata atggtagttt gtaaagtgta       60



ccttccccac aggacgctgt gggatgtaaa tttgtaggtc gagtttacag ctggtttttc      120



ttgactgaag ctcattcaac tggttacttc tttgtgggtg tctttaatga agcttataaa      180



tggcaaaaag caaacattcc catggtttgg catggacatc ggtggaacgc tggttaaatt      240



ggtgtatttc gagccgaagg atattacagc cgaagaggag caagaggaag tggagaacct      300



gaagagcatc cggaagtatt tgacttctaa tactgcttat gggaaaactg ggatccgaga      360



cgtccacctg gaactgaaaa acctgaccat gtgtggacgc aaagggaacc tgcacttcat      420



ccgctttccc agctgtgcta tgcacaggtt cattcagatg ggcagcgaga agaacttctc      480



tagccttcac accaccctct gtgccacagg aggcggggct ttcaaattcg aagaggactt      540



cagaatgatt gctgacctgc agctgcataa actggatgaa ctggactgtc tgattcaggg      600



cctgctttat gtcgactctg ttggcttcaa cggcaagcca gaatgttact attttgaaaa      660



tcccacaaat cctgaattgt gtcaaaaaaa gccgtactgc cttgataacc cataccctat      720



gttgctggtt aacatgggct caggtgtcag cattctagcc gtgtactcca aggacaacta      780



taaaagagtt acagggacca gctttggcaa catgatgagt aaagaaaagc gagattccat      840



cagcaaggaa gacctcgccc gggccacatt ggtcaccatc accaacaaca ttggctccat      900



tgctcggatg tgcgcgttga atgagaacat agacagagtt gtgtttgttg gaaattttct      960



cagaatcaat atggtctcca tgaagctgct ggcatatgcc atggattttt ggtccaaagg     1020



acaactgaaa gctctgtttt tggaacatga gggttatttt ggagccgttg gggcactgtt     1080



ggaactgttc aaaatgactg atgacaagta gagacgagca gtggaggaaa cagcctccca     1140



aaaggacaga gaactaaaaa attgctgctg gagaaggtga aagtcgcttt gggacggaag     1200



ccaagccatt atggcagatg aacctgctgg atttgtaaat aatttaaaat ccttccagat     1260



gatcttttac tcttaggttt tgagctaatg attcaaaacg ggggaatata aaaggttttt     1320



tttctgtata ctgtattttt ttaaaaaaat ggtgcagcgt ggccaaacct accaattgta     1380



tgcattaact ttgaaaagtt gtttgatgtt taagaaggac ctgatatgta agcgctggtc     1440



atttttcttc tggggtttac tgatcagtgt ggtgatttta acttcattta gtaattactc     1500



taggagattt taccttgact tatatttttc atgacgtttc atgatttgct gttggtttca     1560



aatgaaacta caaatctggc atgttttact gtgaacactt ttgttatttg ttttgtaccc     1620



ttttttgtct tgtttttctg ttttagttgt cttctgaaaa aagagtcgtt ccctctgttt     1680



ctgtcctcag atgatgtccc tccccctacc tgtaaccttt ctttgacata attgttcata     1740



tcaatgaagg tgctgaccag ctcaatacaa agttaagcac aagatctaaa gctcttgaaa     1800



atgcccgtga agagaagact gaatgtgtta atgaatttaa tgagtctggc aaaagttgca     1860



aattatatgc aagtttgtcc tatcgcttat aaatgtagtg tttcattgga tttattttat     1920



gctaggttat attaagttga aatagtctgt gattaaatgt cctcatccat gcacagaata     1980



tgaatggcag caaatctttg tgcaagaaat ttgaaactta ttgggaaaag cctcccagta     2040



gattaattgt tcatatcagg agatttaggg taagtcatgg gttgaggtgt cagatagtaa     2100



tatctatttg ttttgtacat gtatatatct aggaactttg taacaacaca tctttaataa     2160



tgttaaaggt tttttcattt ttaatatttt aaactaaaaa ctgtacttca atctcagttt     2220



ctaaaattaa aaataattta tactgatcta tatatttttt ctttttgaaa gatttcatta     2280



agactgatgg gtaactttca aatgagggtc atgtacaaat attgggatgc atgagatccc     2340



atgatcttgt gtattgagct tattgttgaa agggattttt gaaggacaga acaattactc     2400



catgatgaat cttcctttct ctgccttctg agcaccgtct ttaatttcca tatcttcaag     2460



tcttgaagaa gttgatgtta attgaagaat tcacttgtct ggttgaaata aagcctgttt     2520



ctgtt                                                                 2525





<210>  205

<211>  314

<212>  PRT

<213>  Homo sapiens



<400>  205



Met Lys Leu Ile Asn Gly Lys Lys Gln Thr Phe Pro Trp Phe Gly Met 

1               5                   10                  15      





Asp Ile Gly Gly Thr Leu Val Lys Leu Val Tyr Phe Glu Pro Lys Asp 

            20                  25                  30          





Ile Thr Ala Glu Glu Glu Gln Glu Glu Val Glu Asn Leu Lys Ser Ile 

        35                  40                  45              





Arg Lys Tyr Leu Thr Ser Asn Thr Ala Tyr Gly Lys Thr Gly Ile Arg 

    50                  55                  60                  





Asp Val His Leu Glu Leu Lys Asn Leu Thr Met Cys Gly Arg Lys Gly 

65                  70                  75                  80  





Asn Leu His Phe Ile Arg Phe Pro Ser Cys Ala Met His Arg Phe Ile 

                85                  90                  95      





Gln Met Gly Ser Glu Lys Asn Phe Ser Ser Leu His Thr Thr Leu Cys 

            100                 105                 110         





Ala Thr Gly Gly Gly Ala Phe Lys Phe Glu Glu Asp Phe Arg Met Ile 

        115                 120                 125             





Ala Asp Leu Gln Leu His Lys Leu Asp Glu Leu Asp Cys Leu Ile Gln 

    130                 135                 140                 





Gly Leu Leu Tyr Val Asp Ser Val Gly Phe Asn Gly Lys Pro Glu Cys 

145                 150                 155                 160 





Tyr Tyr Phe Glu Asn Pro Thr Asn Pro Glu Leu Cys Gln Lys Lys Pro 

                165                 170                 175     





Tyr Cys Leu Asp Asn Pro Tyr Pro Met Leu Leu Val Asn Met Gly Ser 

            180                 185                 190         





Gly Val Ser Ile Leu Ala Val Tyr Ser Lys Asp Asn Tyr Lys Arg Val 

        195                 200                 205             





Thr Gly Thr Ser Phe Gly Asn Met Met Ser Lys Glu Lys Arg Asp Ser 

    210                 215                 220                 





Ile Ser Lys Glu Asp Leu Ala Arg Ala Thr Leu Val Thr Ile Thr Asn 

225                 230                 235                 240 





Asn Ile Gly Ser Ile Ala Arg Met Cys Ala Leu Asn Glu Asn Ile Asp 

                245                 250                 255     





Arg Val Val Phe Val Gly Asn Phe Leu Arg Ile Asn Met Val Ser Met 

            260                 265                 270         





Lys Leu Leu Ala Tyr Ala Met Asp Phe Trp Ser Lys Gly Gln Leu Lys 

        275                 280                 285             





Ala Leu Phe Leu Glu His Glu Gly Tyr Phe Gly Ala Val Gly Ala Leu 

    290                 295                 300                 





Leu Glu Leu Phe Lys Met Thr Asp Asp Lys 

305                 310                 





<210>  206

<211>  3367

<212>  DNA

<213>  Homo sapiens



<400>  206

cctgacacct ctgcaaataa ttgtcttcct cccgtattcc tcctgaaacg gttcgctcct       60



ttcgctgtct ctcccagacc catctggttt tcacatcgcc atacaaagcc caacccgccc      120



atctcctctc tgcaagccca gagaacttga ttccccatgt tgaaactcgt cggtggcggt      180



ggcgggcagg actgggcatg ctcagtggcg gggaccagtc tgggaggcga ggaagccgcg      240



tttgaagtcg cgcggcctgg ggatcagggg aaggcgggcg gcgggagccc cggctggggg      300



tgcgcgggga tccccgattc cgcgcccggg gctggcgtgc tccaggccgg cgccgtgggg      360



ccggcgcgcg gggggcaggg cgcagaggag gtgggggagt cggcaggagg aggggaggag      420



cgccgggttc gccatcccca ggcgccggct ctgcggctgc tgaatcggaa gccgcaggga      480



ggatccgggg aaataaagac gccggagaat gacctccagc gaggccgcct gagccggggc      540



ccgcgcacag ccccgccagc ccccggcatg ggcgaccgca gcgggcagca ggagcgctcg      600



gtcccgcact ctccaggggc ccccgtgggc accagcgccg ccgctgtgaa cgggctgctg      660



cacaacggct tccatccgcc gccagtccag ccgccgcacg tctgcagccg gggtccagtg      720



ggcggcagcg acgcggcgcc ccagcgcctc ccgctcctgc cggagctgca gccgcagcca      780



ctgctccctc agcatgactc cccggccaag aaatgccggc tgcggaggag gatggactcg      840



gggagaaaga acaggccgcc attcccatgg tttggcatgg acatcggtgg aacgctggtt      900



aaattggtgt atttcgagcc gaaggatatt acagccgaag aggagcaaga ggaagtggag      960



aacctgaaga gcatccggaa gtatttgact tctaatactg cttatgggaa aactgggatc     1020



cgagacgtcc acctggaact gaaaaacctg accatgtgtg gacgcaaagg gaacctgcac     1080



ttcatccgct ttcccagctg tgctatgcac aggttcattc agatgggcag cgagaagaac     1140



ttctctagcc ttcacaccac cctctgtgcc acaggaggcg gggctttcaa attcgaagag     1200



gacttcagaa tgattgctga cctgcagctg cataaactgg atgaactgga ctgtctgatt     1260



cagggcctgc tttatgtcga ctctgttggc ttcaacggca agccagaatg ttactatttt     1320



gaaaatccca caaatcctga attgtgtcaa aaaaagccgt actgccttga taacccatac     1380



cctatgttgc tggttaacat gggctcaggt gtcagcattc tagccgtgta ctccaaggac     1440



aactataaaa gagttacagg gaccagtctt ggaggtggaa cattcctagg cctatgttgc     1500



ttgctgactg gttgtgagac ctttgaagaa gctctggaaa tggcagctaa aggcgacagc     1560



accaatgttg ataaactggt gaaggacatt tacggaggag actatgaacg atttggcctt     1620



caaggatctg ctgtagcatc aagctttggc aacatgatga gtaaagaaaa gcgagattcc     1680



atcagcaagg aagacctcgc ccgggccaca ttggtcacca tcaccaacaa cattggctcc     1740



attgctcgga tgtgcgcgtt gaatgagaac atagacagag ttgtgtttgt tggaaatttt     1800



ctcagaatca atatggtctc catgaagctg ctggcatatg ccatggattt ttggtccaaa     1860



ggacaactga aagctctgtt tttggaacat gagggttatt ttggagccgt tggggcactg     1920



ttggaactgt tcaaaatgac tgatgacaag tagagacgag cagtggagga aacagcctcc     1980



caaaaggaca gagaactaaa aaattgctgc tggagaaggt gaaagtcgct ttgggacgga     2040



agccaagcca ttatggcaga tgaacctgct ggatttgtaa ataatttaaa atccttccag     2100



atgatctttt actcttaggt tttgagctaa tgattcaaaa cgggggaata taaaaggttt     2160



tttttctgta tactgtattt ttttaaaaaa atggtgcagc gtggccaaac ctaccaattg     2220



tatgcattaa ctttgaaaag ttgtttgatg tttaagaagg acctgatatg taagcgctgg     2280



tcatttttct tctggggttt actgatcagt gtggtgattt taacttcatt tagtaattac     2340



tctaggagat tttaccttga cttatatttt tcatgacgtt tcatgatttg ctgttggttt     2400



caaatgaaac tacaaatctg gcatgtttta ctgtgaacac ttttgttatt tgttttgtac     2460



ccttttttgt cttgtttttc tgttttagtt gtcttctgaa aaaagagtcg ttccctctgt     2520



ttctgtcctc agatgatgtc cctcccccta cctgtaacct ttctttgaca taattgttca     2580



tatcaatgaa ggtgctgacc agctcaatac aaagttaagc acaagatcta aagctcttga     2640



aaatgcccgt gaagagaaga ctgaatgtgt taatgaattt aatgagtctg gcaaaagttg     2700



caaattatat gcaagtttgt cctatcgctt ataaatgtag tgtttcattg gatttatttt     2760



atgctaggtt atattaagtt gaaatagtct gtgattaaat gtcctcatcc atgcacagaa     2820



tatgaatggc agcaaatctt tgtgcaagaa atttgaaact tattgggaaa agcctcccag     2880



tagattaatt gttcatatca ggagatttag ggtaagtcat gggttgaggt gtcagatagt     2940



aatatctatt tgttttgtac atgtatatat ctaggaactt tgtaacaaca catctttaat     3000



aatgttaaag gttttttcat ttttaatatt ttaaactaaa aactgtactt caatctcagt     3060



ttctaaaatt aaaaataatt tatactgatc tatatatttt ttctttttga aagatttcat     3120



taagactgat gggtaacttt caaatgaggg tcatgtacaa atattgggat gcatgagatc     3180



ccatgatctt gtgtattgag cttattgttg aaagggattt ttgaaggaca gaacaattac     3240



tccatgatga atcttccttt ctctgccttc tgagcaccgt ctttaatttc catatcttca     3300



agtcttgaag aagttgatgt taattgaaga attcacttgt ctggttgaaa taaagcctgt     3360



ttctgtt                                                               3367





<210>  207

<211>  598

<212>  PRT

<213>  Homo sapiens



<400>  207



Met Leu Lys Leu Val Gly Gly Gly Gly Gly Gln Asp Trp Ala Cys Ser 

1               5                   10                  15      





Val Ala Gly Thr Ser Leu Gly Gly Glu Glu Ala Ala Phe Glu Val Ala 

            20                  25                  30          





Arg Pro Gly Asp Gln Gly Lys Ala Gly Gly Gly Ser Pro Gly Trp Gly 

        35                  40                  45              





Cys Ala Gly Ile Pro Asp Ser Ala Pro Gly Ala Gly Val Leu Gln Ala 

    50                  55                  60                  





Gly Ala Val Gly Pro Ala Arg Gly Gly Gln Gly Ala Glu Glu Val Gly 

65                  70                  75                  80  





Glu Ser Ala Gly Gly Gly Glu Glu Arg Arg Val Arg His Pro Gln Ala 

                85                  90                  95      





Pro Ala Leu Arg Leu Leu Asn Arg Lys Pro Gln Gly Gly Ser Gly Glu 

            100                 105                 110         





Ile Lys Thr Pro Glu Asn Asp Leu Gln Arg Gly Arg Leu Ser Arg Gly 

        115                 120                 125             





Pro Arg Thr Ala Pro Pro Ala Pro Gly Met Gly Asp Arg Ser Gly Gln 

    130                 135                 140                 





Gln Glu Arg Ser Val Pro His Ser Pro Gly Ala Pro Val Gly Thr Ser 

145                 150                 155                 160 





Ala Ala Ala Val Asn Gly Leu Leu His Asn Gly Phe His Pro Pro Pro 

                165                 170                 175     





Val Gln Pro Pro His Val Cys Ser Arg Gly Pro Val Gly Gly Ser Asp 

            180                 185                 190         





Ala Ala Pro Gln Arg Leu Pro Leu Leu Pro Glu Leu Gln Pro Gln Pro 

        195                 200                 205             





Leu Leu Pro Gln His Asp Ser Pro Ala Lys Lys Cys Arg Leu Arg Arg 

    210                 215                 220                 





Arg Met Asp Ser Gly Arg Lys Asn Arg Pro Pro Phe Pro Trp Phe Gly 

225                 230                 235                 240 





Met Asp Ile Gly Gly Thr Leu Val Lys Leu Val Tyr Phe Glu Pro Lys 

                245                 250                 255     





Asp Ile Thr Ala Glu Glu Glu Gln Glu Glu Val Glu Asn Leu Lys Ser 

            260                 265                 270         





Ile Arg Lys Tyr Leu Thr Ser Asn Thr Ala Tyr Gly Lys Thr Gly Ile 

        275                 280                 285             





Arg Asp Val His Leu Glu Leu Lys Asn Leu Thr Met Cys Gly Arg Lys 

    290                 295                 300                 





Gly Asn Leu His Phe Ile Arg Phe Pro Ser Cys Ala Met His Arg Phe 

305                 310                 315                 320 





Ile Gln Met Gly Ser Glu Lys Asn Phe Ser Ser Leu His Thr Thr Leu 

                325                 330                 335     





Cys Ala Thr Gly Gly Gly Ala Phe Lys Phe Glu Glu Asp Phe Arg Met 

            340                 345                 350         





Ile Ala Asp Leu Gln Leu His Lys Leu Asp Glu Leu Asp Cys Leu Ile 

        355                 360                 365             





Gln Gly Leu Leu Tyr Val Asp Ser Val Gly Phe Asn Gly Lys Pro Glu 

    370                 375                 380                 





Cys Tyr Tyr Phe Glu Asn Pro Thr Asn Pro Glu Leu Cys Gln Lys Lys 

385                 390                 395                 400 





Pro Tyr Cys Leu Asp Asn Pro Tyr Pro Met Leu Leu Val Asn Met Gly 

                405                 410                 415     





Ser Gly Val Ser Ile Leu Ala Val Tyr Ser Lys Asp Asn Tyr Lys Arg 

            420                 425                 430         





Val Thr Gly Thr Ser Leu Gly Gly Gly Thr Phe Leu Gly Leu Cys Cys 

        435                 440                 445             





Leu Leu Thr Gly Cys Glu Thr Phe Glu Glu Ala Leu Glu Met Ala Ala 

    450                 455                 460                 





Lys Gly Asp Ser Thr Asn Val Asp Lys Leu Val Lys Asp Ile Tyr Gly 

465                 470                 475                 480 





Gly Asp Tyr Glu Arg Phe Gly Leu Gln Gly Ser Ala Val Ala Ser Ser 

                485                 490                 495     





Phe Gly Asn Met Met Ser Lys Glu Lys Arg Asp Ser Ile Ser Lys Glu 

            500                 505                 510         





Asp Leu Ala Arg Ala Thr Leu Val Thr Ile Thr Asn Asn Ile Gly Ser 

        515                 520                 525             





Ile Ala Arg Met Cys Ala Leu Asn Glu Asn Ile Asp Arg Val Val Phe 

    530                 535                 540                 





Val Gly Asn Phe Leu Arg Ile Asn Met Val Ser Met Lys Leu Leu Ala 

545                 550                 555                 560 





Tyr Ala Met Asp Phe Trp Ser Lys Gly Gln Leu Lys Ala Leu Phe Leu 

                565                 570                 575     





Glu His Glu Gly Tyr Phe Gly Ala Val Gly Ala Leu Leu Glu Leu Phe 

            580                 585                 590         





Lys Met Thr Asp Asp Lys 

        595             





<210>  208

<211>  2702

<212>  DNA

<213>  Homo sapiens



<400>  208

ccgaagtgca ttatttcaca atctaaagct tgtatatata atggtagttt gtaaagtgta       60



ccttccccac aggacgctgt gggatgtaaa tttgtaggtc gagtttacag ctggtttttc      120



ttgactgaag ctcattcaac tggttacttc tttgtgggtg tctttaatga agcttataaa      180



tggcaaaaag caaacattcc catggtttgg catggacatc ggtggaacgc tggttaaatt      240



ggtgtatttc gagccgaagg atattacagc cgaagaggag caagaggaag tggagaacct      300



gaagagcatc cggaagtatt tgacttctaa tactgcttat gggaaaactg ggatccgaga      360



cgtccacctg gaactgaaaa acctgaccat gtgtggacgc aaagggaacc tgcacttcat      420



ccgctttccc agctgtgcta tgcacaggtt cattcagatg ggcagcgaga agaacttctc      480



tagccttcac accaccctct gtgccacagg aggcggggct ttcaaattcg aagaggactt      540



cagaatgatt gctgacctgc agctgcataa actggatgaa ctggactgtc tgattcaggg      600



cctgctttat gtcgactctg ttggcttcaa cggcaagcca gaatgttact attttgaaaa      660



tcccacaaat cctgaattgt gtcaaaaaaa gccgtactgc cttgataacc cataccctat      720



gttgctggtt aacatgggct caggtgtcag cattctagcc gtgtactcca aggacaacta      780



taaaagagtt acagggacca gtcttggagg tggaacattc ctaggcctat gttgcttgct      840



gactggttgt gagacctttg aagaagctct ggaaatggca gctaaaggcg acagcaccaa      900



tgttgataaa ctggtgaagg acatttacgg aggagactat gaacgatttg gccttcaagg      960



atctgctgta gcatcaagct ttggcaacat gatgagtaaa gaaaagcgag attccatcag     1020



caaggaagac ctcgcccggg ccacattggt caccatcacc aacaacattg gctccattgc     1080



tcggatgtgc gcgttgaatg agaacataga cagagttgtg tttgttggaa attttctcag     1140



aatcaatatg gtctccatga agctgctggc atatgccatg gatttttggt ccaaaggaca     1200



actgaaagct ctgtttttgg aacatgaggg ttattttgga gccgttgggg cactgttgga     1260



actgttcaaa atgactgatg acaagtagag acgagcagtg gaggaaacag cctcccaaaa     1320



ggacagagaa ctaaaaaatt gctgctggag aaggtgaaag tcgctttggg acggaagcca     1380



agccattatg gcagatgaac ctgctggatt tgtaaataat ttaaaatcct tccagatgat     1440



cttttactct taggttttga gctaatgatt caaaacgggg gaatataaaa ggtttttttt     1500



ctgtatactg tattttttta aaaaaatggt gcagcgtggc caaacctacc aattgtatgc     1560



attaactttg aaaagttgtt tgatgtttaa gaaggacctg atatgtaagc gctggtcatt     1620



tttcttctgg ggtttactga tcagtgtggt gattttaact tcatttagta attactctag     1680



gagattttac cttgacttat atttttcatg acgtttcatg atttgctgtt ggtttcaaat     1740



gaaactacaa atctggcatg ttttactgtg aacacttttg ttatttgttt tgtacccttt     1800



tttgtcttgt ttttctgttt tagttgtctt ctgaaaaaag agtcgttccc tctgtttctg     1860



tcctcagatg atgtccctcc ccctacctgt aacctttctt tgacataatt gttcatatca     1920



atgaaggtgc tgaccagctc aatacaaagt taagcacaag atctaaagct cttgaaaatg     1980



cccgtgaaga gaagactgaa tgtgttaatg aatttaatga gtctggcaaa agttgcaaat     2040



tatatgcaag tttgtcctat cgcttataaa tgtagtgttt cattggattt attttatgct     2100



aggttatatt aagttgaaat agtctgtgat taaatgtcct catccatgca cagaatatga     2160



atggcagcaa atctttgtgc aagaaatttg aaacttattg ggaaaagcct cccagtagat     2220



taattgttca tatcaggaga tttagggtaa gtcatgggtt gaggtgtcag atagtaatat     2280



ctatttgttt tgtacatgta tatatctagg aactttgtaa caacacatct ttaataatgt     2340



taaaggtttt ttcattttta atattttaaa ctaaaaactg tacttcaatc tcagtttcta     2400



aaattaaaaa taatttatac tgatctatat attttttctt tttgaaagat ttcattaaga     2460



ctgatgggta actttcaaat gagggtcatg tacaaatatt gggatgcatg agatcccatg     2520



atcttgtgta ttgagcttat tgttgaaagg gatttttgaa ggacagaaca attactccat     2580



gatgaatctt cctttctctg ccttctgagc accgtcttta atttccatat cttcaagtct     2640



tgaagaagtt gatgttaatt gaagaattca cttgtctggt tgaaataaag cctgtttctg     2700



tt                                                                    2702





<210>  209

<211>  373

<212>  PRT

<213>  Homo sapiens



<400>  209



Met Lys Leu Ile Asn Gly Lys Lys Gln Thr Phe Pro Trp Phe Gly Met 

1               5                   10                  15      





Asp Ile Gly Gly Thr Leu Val Lys Leu Val Tyr Phe Glu Pro Lys Asp 

            20                  25                  30          





Ile Thr Ala Glu Glu Glu Gln Glu Glu Val Glu Asn Leu Lys Ser Ile 

        35                  40                  45              





Arg Lys Tyr Leu Thr Ser Asn Thr Ala Tyr Gly Lys Thr Gly Ile Arg 

    50                  55                  60                  





Asp Val His Leu Glu Leu Lys Asn Leu Thr Met Cys Gly Arg Lys Gly 

65                  70                  75                  80  





Asn Leu His Phe Ile Arg Phe Pro Ser Cys Ala Met His Arg Phe Ile 

                85                  90                  95      





Gln Met Gly Ser Glu Lys Asn Phe Ser Ser Leu His Thr Thr Leu Cys 

            100                 105                 110         





Ala Thr Gly Gly Gly Ala Phe Lys Phe Glu Glu Asp Phe Arg Met Ile 

        115                 120                 125             





Ala Asp Leu Gln Leu His Lys Leu Asp Glu Leu Asp Cys Leu Ile Gln 

    130                 135                 140                 





Gly Leu Leu Tyr Val Asp Ser Val Gly Phe Asn Gly Lys Pro Glu Cys 

145                 150                 155                 160 





Tyr Tyr Phe Glu Asn Pro Thr Asn Pro Glu Leu Cys Gln Lys Lys Pro 

                165                 170                 175     





Tyr Cys Leu Asp Asn Pro Tyr Pro Met Leu Leu Val Asn Met Gly Ser 

            180                 185                 190         





Gly Val Ser Ile Leu Ala Val Tyr Ser Lys Asp Asn Tyr Lys Arg Val 

        195                 200                 205             





Thr Gly Thr Ser Leu Gly Gly Gly Thr Phe Leu Gly Leu Cys Cys Leu 

    210                 215                 220                 





Leu Thr Gly Cys Glu Thr Phe Glu Glu Ala Leu Glu Met Ala Ala Lys 

225                 230                 235                 240 





Gly Asp Ser Thr Asn Val Asp Lys Leu Val Lys Asp Ile Tyr Gly Gly 

                245                 250                 255     





Asp Tyr Glu Arg Phe Gly Leu Gln Gly Ser Ala Val Ala Ser Ser Phe 

            260                 265                 270         





Gly Asn Met Met Ser Lys Glu Lys Arg Asp Ser Ile Ser Lys Glu Asp 

        275                 280                 285             





Leu Ala Arg Ala Thr Leu Val Thr Ile Thr Asn Asn Ile Gly Ser Ile 

    290                 295                 300                 





Ala Arg Met Cys Ala Leu Asn Glu Asn Ile Asp Arg Val Val Phe Val 

305                 310                 315                 320 





Gly Asn Phe Leu Arg Ile Asn Met Val Ser Met Lys Leu Leu Ala Tyr 

                325                 330                 335     





Ala Met Asp Phe Trp Ser Lys Gly Gln Leu Lys Ala Leu Phe Leu Glu 

            340                 345                 350         





His Glu Gly Tyr Phe Gly Ala Val Gly Ala Leu Leu Glu Leu Phe Lys 

        355                 360                 365             





Met Thr Asp Asp Lys 

    370             





<210>  210

<211>  4603

<212>  DNA

<213>  Homo sapiens



<400>  210

ctggtggtcc agtacctcca aagatatgga atacactcct gaaatatcct gaaaactttt       60



ttttttcaga atcctttaat aagcagttat gtcaatctga aagttgctta cttgtacttt      120



atattaatag ctattcttgt ttttcttatc caaagaaaaa tcctctaatc cccttttcac      180



atgatagttg ttaccatgtt taggcattag tcacatcaac ccctctcctc tcccaaactt      240



ctcttcttca aatcaaactt tattagtccc tcctttataa tgattccttg cctcgtttta      300



tccagatcaa ttttttttca ctttgatgcc cagagctgaa gaaatggact actgtataaa      360



ttattcattg ccaagagaat aattgcattt taaacccata ttataacaaa gaataatgat      420



tatattttgt gatttgtaac aaataccctt tattttccct taactattga attaaatatt      480



ttaattattt gtattctctt taactatctt ggtatattaa agtattatct tttatatatt      540



tatcaatggt ggacactttt ataggtactc tgtgtcattt ttgatactgt aggtatctta      600



tttcatttat ctttattctt aatgtacgaa ttcataatat ttgattcaga acaaatttat      660



cactaattaa cagagtgtca attatgctaa catctcattt actgatttta atttaaaaca      720



gtttttgtta acatgcatgt ttagggttgg cttcttaata atttcttctt cctcttctct      780



ctctcctctt cttttggtca gtgttgtgcg ggttaataca acaaactgta acaagtgtac      840



ctggtatgga cttgttgtcc gggacgtaca ttttcgcggt cctgctagca tgcgtggtgt      900



tccactctgg cgcccaggag aaaaactaca ccatccgaga agaaatgcca gaaaacgtcc      960



tgataggcga cttgttgaaa gaccttaact tgtcgctgat tccaaacaag tccttgacaa     1020



ctgctatgca gttcaagcta gtgtacaaga ccggagatgt gccactgatt cgaattgaag     1080



aggatactgg tgagatcttc actactggcg ctcgcattga tcgtgagaaa ttatgtgctg     1140



gtatcccaag ggatgagcat tgcttttatg aagtggaggt tgccattttg ccggatgaaa     1200



tatttagact ggttaagata cgttttctga tagaagatat aaatgataat gcaccattgt     1260



tcccagcaac agttatcaac atatcaattc cagagaactc ggctataaac tctaaatata     1320



ctctcccagc ggctgttgat cctgacgtag gaataaacgg agttcaaaac tacgaactaa     1380



ttaagagtca aaacattttt ggcctcgatg tcattgaaac accagaagga gacaagatgc     1440



cacaactgat tgttcaaaag gagttagata gggaagagaa ggatacctac gtgatgaaag     1500



taaaggttga agatggtggc tttcctcaaa gatccagtac tgctattttg caagtgagtg     1560



ttactgatac aaatgacaac cacccagtct ttaaggagac agagattgaa gtcagtatac     1620



cagaaaatgc tcctgtaggc acttcagtga cacagctcca tgccacagat gctgacatag     1680



gtgaaaatgc caagatccac ttctctttca gcaatctagt ctccaacatt gccaggagat     1740



tatttcacct caatgccacc actggactta tcacaatcaa agaaccactg gatagggaag     1800



aaacaccaaa ccacaagtta ctggttttgg caagtgatgg tggattgatg ccagcaagag     1860



caatggtgct ggtaaatgtt acagatgtca atgataatgt cccatccatt gacataagat     1920



acatcgtcaa tcctgtcaat gacacagttg ttctttcaga aaatattcca ctcaacacca     1980



aaattgctct cataactgtg acggataagg atgcggacca taatggcagg gtgacatgct     2040



tcacagatca tgaaatccct ttcagattaa ggccagtatt cagtaatcag ttcctcctgg     2100



agactgcagc atatcttgac tatgagtcca caaaagaata tgccattaaa ttactggctg     2160



cagatgctgg caaacctcct ttgaatcagt cagcaatgct cttcatcaaa gtgaaagatg     2220



aaaatgacaa tgctccagtt ttcacccagt ctttcgtaac tgtttctatt cctgagaata     2280



actctcctgg catccagttg acgaaagtaa gtgcaatgga tgcagacagt gggcctaatg     2340



ctaagatcaa ttacctgcta ggccctgatg ctccacctga attcagcctg gattgtcgta     2400



caggcatgct gactgtagtg aagaaactag atagagaaaa agaggataaa tatttattca     2460



caattctggc aaaagataac ggggtaccac ccttaaccag caatgtcaca gtctttgtaa     2520



gcattattga tcagaatgac aatagcccag ttttcactca caatgaatac aacttctatg     2580



tcccagaaaa ccttccaagg catggtacag taggactaat cactgtaact gatcctgatt     2640



atggagacaa ttctgcagtt acgctctcca ttttagatga gaatgatgac ttcaccattg     2700



attcacaaac tggtgtcatc cgaccaaata tttcatttga tagagaaaaa caagaatctt     2760



acactttcta tgtaaaggct gaggatggtg gtagagtatc acgttcttca agtgccaaag     2820



taaccataaa tgtggttgat gtcaatgaca acaaaccagt tttcattgtc cctccttcca     2880



actgttctta tgaattggtt ctaccgtcca ctaatccagg cacagtggtc tttcaggtaa     2940



ttgctgttga caatgacact ggcatgaatg cagaggttcg ttacagcatt gtaggaggaa     3000



acacaagaga tctgtttgca atcgaccaag aaacaggcaa cataacattg atggagaaat     3060



gtgatgttac agaccttggt ttacacagag tgttggtcaa agctaatgac ttaggacagc     3120



ctgattctct cttcagtgtt gtaattgtca atctgttcgt gaatgagtcg gtgaccaatg     3180



ctacactgat taatgaactg gtgcgcaaaa gcactgaagc accagtgacc ccaaatactg     3240



agatagctga tgtatcctca ccaactagtg actatgtcaa gatcctggtt gcagctgttg     3300



ctggcaccat aactgtcgtt gtagttattt tcatcactgc tgtagtaaga tgtcgccagg     3360



caccacacct taaggctgct cagaaaaaca agcagaattc tgaatgggct accccaaacc     3420



cagaaaacag gcagatgata atgatgaaga aaaagaaaaa gaagaagaag cattccccta     3480



agaacttgct gcttaatttt gtcactattg aagaaactaa ggcagatgat gttgacagtg     3540



atggaaacag agtcacacta gaccttccta ttgatctaga agagcaaaca atgggaaagt     3600



acaattgggt aactacacct actactttca agcccgacag ccctgatttg gcccgacact     3660



acaaatctgc ctctccacag cctgccttcc aaattcagcc tgaaactccc ctgaattcga     3720



agcaccacat catccaagaa ctgcctctcg ataacacctt tgtggcctgt gactctatct     3780



ccaagtgttc ctcaagcagt tcagatccct acagcgtttc tgactgtggc tatccagtga     3840



cgaccttcga ggtacctgtg tccgtacaca ccagaccggt aggtatccaa gtttctaaca     3900



caactttcta actatttttt tattattatt ttcagttgat gtagaacttt acaaaatcta     3960



ttgacttcaa agagggatca aaacaatcat attctacaga tgtacccaat agatatatgg     4020



attcaattaa gtttggtaga agatgagaac aaaataacta ctgatttagg aaaattggat     4080



gcagaataat aattatagta ggggcaattt tgtctgtaga tggcagtatg acaattcttg     4140



ctagagaata tattgaaaaa aacttcaaca caaagggttg tagcactgtc ctcagtacca     4200



ttgtgtgcat gaggatcaga atagtctggg ctagatacat cacattaaag cttttcagaa     4260



tctgataaat agctctaaat actaatgata ttgagaagcc tagcttcact tgggaaaatc     4320



tgtggctgtt cacagaaatt cagcaccaag ttattccccc catactctac caggccttca     4380



ggtcctcata aagaaaagtg tcgttttcag attaggaact caaaattatt ttggtgcatc     4440



aaatctacag tcacacaata taacaagaat gggattagaa aaatgaaagc ctactcattc     4500



tcatctttaa gccagagaat gaaatatata tgaggtctct ggatagctat ttaaatattt     4560



gcatatttat gcaaggtatt ttgagccctt cagaagacat tct                       4603





<210>  211

<211>  1021

<212>  PRT

<213>  Homo sapiens



<400>  211



Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys 

1               5                   10                  15      





Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu 

            20                  25                  30          





Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn 

        35                  40                  45              





Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys 

    50                  55                  60                  





Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp 

65                  70                  75                  80  





Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu 

                85                  90                  95      





Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val 

            100                 105                 110         





Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu 

        115                 120                 125             





Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile 

    130                 135                 140                 





Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu 

145                 150                 155                 160 





Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr 

                165                 170                 175     





Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr 

            180                 185                 190         





Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp 

        195                 200                 205             





Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly 

    210                 215                 220                 





Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr 

225                 230                 235                 240 





Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val 

                245                 250                 255     





Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His 

            260                 265                 270         





Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe 

        275                 280                 285             





Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala 

    290                 295                 300                 





Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr 

305                 310                 315                 320 





Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro 

                325                 330                 335     





Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val 

            340                 345                 350         





Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val 

        355                 360                 365             





Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr 

    370                 375                 380                 





Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr 

385                 390                 395                 400 





Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe 

                405                 410                 415     





Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr 

            420                 425                 430         





Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln 

        435                 440                 445             





Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro 

    450                 455                 460                 





Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser 

465                 470                 475                 480 





Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly 

                485                 490                 495     





Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu 

            500                 505                 510         





Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu 

        515                 520                 525             





Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp 

    530                 535                 540                 





Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile 

545                 550                 555                 560 





Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn 

                565                 570                 575     





Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile 

            580                 585                 590         





Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser 

        595                 600                 605             





Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val 

    610                 615                 620                 





Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr 

625                 630                 635                 640 





Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser 

                645                 650                 655     





Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val 

            660                 665                 670         





Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser 

        675                 680                 685             





Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp 

    690                 695                 700                 





Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr 

705                 710                 715                 720 





Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met 

                725                 730                 735     





Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys 

            740                 745                 750         





Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val 

        755                 760                 765             





Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu 

    770                 775                 780                 





Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile 

785                 790                 795                 800 





Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala 

                805                 810                 815     





Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala 

            820                 825                 830         





Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn 

        835                 840                 845             





Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met 

    850                 855                 860                 





Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn 

865                 870                 875                 880 





Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val 

                885                 890                 895     





Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu 

            900                 905                 910         





Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe 

        915                 920                 925             





Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro 

    930                 935                 940                 





Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His 

945                 950                 955                 960 





His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp 

                965                 970                 975     





Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser 

            980                 985                 990         





Asp Cys Gly Tyr Pro Val Thr Thr  Phe Glu Val Pro Val  Ser Val His 

        995                 1000                 1005             





Thr Arg  Pro Val Gly Ile Gln  Val Ser Asn Thr Thr  Phe 

    1010                 1015                 1020     





<210>  212

<211>  4723

<212>  DNA

<213>  Homo sapiens



<400>  212

cccctttctc cccctcggtt aagtccctcc ccctcgccat tcaaaagggc tggctcggca       60



ctggctcctt gcagtcggcg aactgtcggg gcgggaggag ccgtgagcag tagctgcact      120



cagctgcccg cgcggcaaag aggaaggcaa gccaaacaga gtgcgcagag tggcagtgcc      180



agcggcgaca caggcagcac aggcagcccg ggctgcctga atagcctcag aaacaacctc      240



agcgactccg gctgctctgc ggactgcgag ctgtggcggt agagcccgct acagcagtcg      300



cagtctccgt ggagcgggcg gaagcctttt ttctcccttt cgtttacctc ttcattctac      360



tctaaaggca tcgttattag gaaaatcctg ttgcgaataa gaaggattcc acagatcaca      420



taccggagag gttttgcctc agctgctctc aactttgtaa tcttgtgaag aagctgacaa      480



gcttggctga ttgcagagca ctatgaggac tgaacgacag tgggttttaa ttcagatatt      540



tcaagtgttg tgcgggttaa tacaacaaac tgtaacaagt gtacctggta tggacttgtt      600



gtccgggacg tacattttcg cggtcctgct agcatgcgtg gtgttccact ctggcgccca      660



ggagaaaaac tacaccatcc gagaagaaat gccagaaaac gtcctgatag gcgacttgtt      720



gaaagacctt aacttgtcgc tgattccaaa caagtccttg acaactgcta tgcagttcaa      780



gctagtgtac aagaccggag atgtgccact gattcgaatt gaagaggata ctggtgagat      840



cttcactact ggcgctcgca ttgatcgtga gaaattatgt gctggtatcc caagggatga      900



gcattgcttt tatgaagtgg aggttgccat tttgccggat gaaatattta gactggttaa      960



gatacgtttt ctgatagaag atataaatga taatgcacca ttgttcccag caacagttat     1020



caacatatca attccagaga actcggctat aaactctaaa tatactctcc cagcggctgt     1080



tgatcctgac gtaggaataa acggagttca aaactacgaa ctaattaaga gtcaaaacat     1140



ttttggcctc gatgtcattg aaacaccaga aggagacaag atgccacaac tgattgttca     1200



aaaggagtta gatagggaag agaaggatac ctacgtgatg aaagtaaagg ttgaagatgg     1260



tggctttcct caaagatcca gtactgctat tttgcaagtg agtgttactg atacaaatga     1320



caaccaccca gtctttaagg agacagagat tgaagtcagt ataccagaaa atgctcctgt     1380



aggcacttca gtgacacagc tccatgccac agatgctgac ataggtgaaa atgccaagat     1440



ccacttctct ttcagcaatc tagtctccaa cattgccagg agattatttc acctcaatgc     1500



caccactgga cttatcacaa tcaaagaacc actggatagg gaagaaacac caaaccacaa     1560



gttactggtt ttggcaagtg atggtggatt gatgccagca agagcaatgg tgctggtaaa     1620



tgttacagat gtcaatgata atgtcccatc cattgacata agatacatcg tcaatcctgt     1680



caatgacaca gttgttcttt cagaaaatat tccactcaac accaaaattg ctctcataac     1740



tgtgacggat aaggatgcgg accataatgg cagggtgaca tgcttcacag atcatgaaat     1800



ccctttcaga ttaaggccag tattcagtaa tcagttcctc ctggagactg cagcatatct     1860



tgactatgag tccacaaaag aatatgccat taaattactg gctgcagatg ctggcaaacc     1920



tcctttgaat cagtcagcaa tgctcttcat caaagtgaaa gatgaaaatg acaatgctcc     1980



agttttcacc cagtctttcg taactgtttc tattcctgag aataactctc ctggcatcca     2040



gttgacgaaa gtaagtgcaa tggatgcaga cagtgggcct aatgctaaga tcaattacct     2100



gctaggccct gatgctccac ctgaattcag cctggattgt cgtacaggca tgctgactgt     2160



agtgaagaaa ctagatagag aaaaagagga taaatattta ttcacaattc tggcaaaaga     2220



taacggggta ccacccttaa ccagcaatgt cacagtcttt gtaagcatta ttgatcagaa     2280



tgacaatagc ccagttttca ctcacaatga atacaacttc tatgtcccag aaaaccttcc     2340



aaggcatggt acagtaggac taatcactgt aactgatcct gattatggag acaattctgc     2400



agttacgctc tccattttag atgagaatga tgacttcacc attgattcac aaactggtgt     2460



catccgacca aatatttcat ttgatagaga aaaacaagaa tcttacactt tctatgtaaa     2520



ggctgaggat ggtggtagag tatcacgttc ttcaagtgcc aaagtaacca taaatgtggt     2580



tgatgtcaat gacaacaaac cagttttcat tgtccctcct tccaactgtt cttatgaatt     2640



ggttctaccg tccactaatc caggcacagt ggtctttcag gtaattgctg ttgacaatga     2700



cactggcatg aatgcagagg ttcgttacag cattgtagga ggaaacacaa gagatctgtt     2760



tgcaatcgac caagaaacag gcaacataac attgatggag aaatgtgatg ttacagacct     2820



tggtttacac agagtgttgg tcaaagctaa tgacttagga cagcctgatt ctctcttcag     2880



tgttgtaatt gtcaatctgt tcgtgaatga gtcggtgacc aatgctacac tgattaatga     2940



actggtgcgc aaaagcactg aagcaccagt gaccccaaat actgagatag ctgatgtatc     3000



ctcaccaact agtgactatg tcaagatcct ggttgcagct gttgctggca ccataactgt     3060



cgttgtagtt attttcatca ctgctgtagt aagatgtcgc caggcaccac accttaaggc     3120



tgctcagaaa aacaagcaga attctgaatg ggctacccca aacccagaaa acaggcagat     3180



gataatgatg aagaaaaaga aaaagaagaa gaagcattcc cctaagaact tgctgcttaa     3240



ttttgtcact attgaagaaa ctaaggcaga tgatgttgac agtgatggaa acagagtcac     3300



actagacctt cctattgatc tagaagagca aacaatggga aagtacaatt gggtaactac     3360



acctactact ttcaagcccg acagccctga tttggcccga cactacaaat ctgcctctcc     3420



acagcctgcc ttccaaattc agcctgaaac tcccctgaat tcgaagcacc acatcatcca     3480



agaactgcct ctcgataaca cctttgtggc ctgtgactct atctccaagt gttcctcaag     3540



cagttcagat ccctacagcg tttctgactg tggctatcca gtgacgacct tcgaggtacc     3600



tgtgtccgta cacaccagac cgactgattc caggacatca actattgaaa tctgcagtga     3660



gatataactt tctaggaaca acaaaattcc attccccttc caaaaaattt caatgattgt     3720



gatttcaaaa ttaggctaag atcattaatt ttgtaatcta gatttcccat tataaaagca     3780



agcaaaaatc atcttaaaaa tgatgtccta gtgaaccttg tgctttcttt agctgtaatc     3840



tggcaatgga aatttaaaat ttatggaaga gacagtgcag cacaataaca gagtactctc     3900



atgctgtttc tctgtttgct ctgaatcaac agccatgatg taatataagg ctgtcttggt     3960



gtatacactt atggttaata tatcagtcat gaaacatgca attacttgcc ctgtctgatt     4020



gttgaataat taaaacatta tctccaggag tttggaagtg agctgaacta gccaaactac     4080



tctctgaaag gtatccaggg caagagacat ttttaagacc ccaaacaaac aaaaaacaaa     4140



accaaaacac tctggttcag tgttttgaaa atattcacta acataatatt gctgagaaaa     4200



tcatttttat tacccaccac tctgcttaaa agttgagtgg gccgggcgcg gtggctcacg     4260



cctgtaatcc cagcactttg ggaggccgag gcgggtggat cacgaggtca ggagattgag     4320



accatcctgg ctaacacggt gaaaccccat ctccactaaa aatacaaaaa attagcctgg     4380



cgtggtggcg ggcgcctgta gtcccagcta ctcgggaggc tgaggcagga gaatagcgtg     4440



aacccgggag gcggagcttg cagtgagccg agatggcgcc actgcactcc agcctgggtg     4500



acagagcaag actctgtctc aaaaagaaaa aaatgttcaa tgatagaaaa taattttact     4560



aggtttttat gttgattgta ctcatgctgt tccactcctt ttaattatta aaaagttatt     4620



tttggctggg tgtggtggct cacacctgta atcccagcac tttgggaggc cgaggtgggt     4680



ggatcacctg aggtcaggag ttcaagacca gtctggccaa cat                       4723





<210>  213

<211>  1025

<212>  PRT

<213>  Homo sapiens



<400>  213



Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys 

1               5                   10                  15      





Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu 

            20                  25                  30          





Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn 

        35                  40                  45              





Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys 

    50                  55                  60                  





Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp 

65                  70                  75                  80  





Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu 

                85                  90                  95      





Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val 

            100                 105                 110         





Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu 

        115                 120                 125             





Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile 

    130                 135                 140                 





Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu 

145                 150                 155                 160 





Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr 

                165                 170                 175     





Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr 

            180                 185                 190         





Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp 

        195                 200                 205             





Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly 

    210                 215                 220                 





Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr 

225                 230                 235                 240 





Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val 

                245                 250                 255     





Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His 

            260                 265                 270         





Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe 

        275                 280                 285             





Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala 

    290                 295                 300                 





Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr 

305                 310                 315                 320 





Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro 

                325                 330                 335     





Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val 

            340                 345                 350         





Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val 

        355                 360                 365             





Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr 

    370                 375                 380                 





Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr 

385                 390                 395                 400 





Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe 

                405                 410                 415     





Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr 

            420                 425                 430         





Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln 

        435                 440                 445             





Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro 

    450                 455                 460                 





Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser 

465                 470                 475                 480 





Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly 

                485                 490                 495     





Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu 

            500                 505                 510         





Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu 

        515                 520                 525             





Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp 

    530                 535                 540                 





Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile 

545                 550                 555                 560 





Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn 

                565                 570                 575     





Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile 

            580                 585                 590         





Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser 

        595                 600                 605             





Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val 

    610                 615                 620                 





Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr 

625                 630                 635                 640 





Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser 

                645                 650                 655     





Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val 

            660                 665                 670         





Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser 

        675                 680                 685             





Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp 

    690                 695                 700                 





Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr 

705                 710                 715                 720 





Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met 

                725                 730                 735     





Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys 

            740                 745                 750         





Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val 

        755                 760                 765             





Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu 

    770                 775                 780                 





Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile 

785                 790                 795                 800 





Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala 

                805                 810                 815     





Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala 

            820                 825                 830         





Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn 

        835                 840                 845             





Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met 

    850                 855                 860                 





Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn 

865                 870                 875                 880 





Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val 

                885                 890                 895     





Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu 

            900                 905                 910         





Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe 

        915                 920                 925             





Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro 

    930                 935                 940                 





Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His 

945                 950                 955                 960 





His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp 

                965                 970                 975     





Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser 

            980                 985                 990         





Asp Cys Gly Tyr Pro Val Thr Thr  Phe Glu Val Pro Val  Ser Val His 

        995                 1000                 1005             





Thr Arg  Pro Thr Asp Ser Arg  Thr Ser Thr Ile Glu  Ile Cys Ser 

    1010                 1015                 1020             





Glu Ile  

    1025 





<210>  214

<211>  9176

<212>  DNA

<213>  Homo sapiens



<400>  214

ctggtggtcc agtacctcca aagatatgga atacactcct gaaatatcct gaaaactttt       60



ttttttcaga atcctttaat aagcagttat gtcaatctga aagttgctta cttgtacttt      120



atattaatag ctattcttgt ttttcttatc caaagaaaaa tcctctaatc cccttttcac      180



atgatagttg ttaccatgtt taggcattag tcacatcaac ccctctcctc tcccaaactt      240



ctcttcttca aatcaaactt tattagtccc tcctttataa tgattccttg cctcgtttta      300



tccagatcaa ttttttttca ctttgatgcc cagagctgaa gaaatggact actgtataaa      360



ttattcattg ccaagagaat aattgcattt taaacccata ttataacaaa gaataatgat      420



tatattttgt gatttgtaac aaataccctt tattttccct taactattga attaaatatt      480



ttaattattt gtattctctt taactatctt ggtatattaa agtattatct tttatatatt      540



tatcaatggt ggacactttt ataggtactc tgtgtcattt ttgatactgt aggtatctta      600



tttcatttat ctttattctt aatgtacgaa ttcataatat ttgattcaga acaaatttat      660



cactaattaa cagagtgtca attatgctaa catctcattt actgatttta atttaaaaca      720



gtttttgtta acatgcatgt ttagggttgg cttcttaata atttcttctt cctcttctct      780



ctctcctctt cttttggtca gtgttgtgcg ggttaataca acaaactgta acaagtgtac      840



ctggtatgga cttgttgtcc gggacgtaca ttttcgcggt cctgctagca tgcgtggtgt      900



tccactctgg cgcccaggag aaaaactaca ccatccgaga agaaatgcca gaaaacgtcc      960



tgataggcga cttgttgaaa gaccttaact tgtcgctgat tccaaacaag tccttgacaa     1020



ctgctatgca gttcaagcta gtgtacaaga ccggagatgt gccactgatt cgaattgaag     1080



aggatactgg tgagatcttc actactggcg ctcgcattga tcgtgagaaa ttatgtgctg     1140



gtatcccaag ggatgagcat tgcttttatg aagtggaggt tgccattttg ccggatgaaa     1200



tatttagact ggttaagata cgttttctga tagaagatat aaatgataat gcaccattgt     1260



tcccagcaac agttatcaac atatcaattc cagagaactc ggctataaac tctaaatata     1320



ctctcccagc ggctgttgat cctgacgtag gaataaacgg agttcaaaac tacgaactaa     1380



ttaagagtca aaacattttt ggcctcgatg tcattgaaac accagaagga gacaagatgc     1440



cacaactgat tgttcaaaag gagttagata gggaagagaa ggatacctac gtgatgaaag     1500



taaaggttga agatggtggc tttcctcaaa gatccagtac tgctattttg caagtgagtg     1560



ttactgatac aaatgacaac cacccagtct ttaaggagac agagattgaa gtcagtatac     1620



cagaaaatgc tcctgtaggc acttcagtga cacagctcca tgccacagat gctgacatag     1680



gtgaaaatgc caagatccac ttctctttca gcaatctagt ctccaacatt gccaggagat     1740



tatttcacct caatgccacc actggactta tcacaatcaa agaaccactg gatagggaag     1800



aaacaccaaa ccacaagtta ctggttttgg caagtgatgg tggattgatg ccagcaagag     1860



caatggtgct ggtaaatgtt acagatgtca atgataatgt cccatccatt gacataagat     1920



acatcgtcaa tcctgtcaat gacacagttg ttctttcaga aaatattcca ctcaacacca     1980



aaattgctct cataactgtg acggataagg atgcggacca taatggcagg gtgacatgct     2040



tcacagatca tgaaatccct ttcagattaa ggccagtatt cagtaatcag ttcctcctgg     2100



agactgcagc atatcttgac tatgagtcca caaaagaata tgccattaaa ttactggctg     2160



cagatgctgg caaacctcct ttgaatcagt cagcaatgct cttcatcaaa gtgaaagatg     2220



aaaatgacaa tgctccagtt ttcacccagt ctttcgtaac tgtttctatt cctgagaata     2280



actctcctgg catccagttg acgaaagtaa gtgcaatgga tgcagacagt gggcctaatg     2340



ctaagatcaa ttacctgcta ggccctgatg ctccacctga attcagcctg gattgtcgta     2400



caggcatgct gactgtagtg aagaaactag atagagaaaa agaggataaa tatttattca     2460



caattctggc aaaagataac ggggtaccac ccttaaccag caatgtcaca gtctttgtaa     2520



gcattattga tcagaatgac aatagcccag ttttcactca caatgaatac aacttctatg     2580



tcccagaaaa ccttccaagg catggtacag taggactaat cactgtaact gatcctgatt     2640



atggagacaa ttctgcagtt acgctctcca ttttagatga gaatgatgac ttcaccattg     2700



attcacaaac tggtgtcatc cgaccaaata tttcatttga tagagaaaaa caagaatctt     2760



acactttcta tgtaaaggct gaggatggtg gtagagtatc acgttcttca agtgccaaag     2820



taaccataaa tgtggttgat gtcaatgaca acaaaccagt tttcattgtc cctccttcca     2880



actgttctta tgaattggtt ctaccgtcca ctaatccagg cacagtggtc tttcaggtaa     2940



ttgctgttga caatgacact ggcatgaatg cagaggttcg ttacagcatt gtaggaggaa     3000



acacaagaga tctgtttgca atcgaccaag aaacaggcaa cataacattg atggagaaat     3060



gtgatgttac agaccttggt ttacacagag tgttggtcaa agctaatgac ttaggacagc     3120



ctgattctct cttcagtgtt gtaattgtca atctgttcgt gaatgagtcg gtgaccaatg     3180



ctacactgat taatgaactg gtgcgcaaaa gcactgaagc accagtgacc ccaaatactg     3240



agatagctga tgtatcctca ccaactagtg actatgtcaa gatcctggtt gcagctgttg     3300



ctggcaccat aactgtcgtt gtagttattt tcatcactgc tgtagtaaga tgtcgccagg     3360



caccacacct taaggctgct cagaaaaaca agcagaattc tgaatgggct accccaaacc     3420



cagaaaacag gcagatgata atgatgaaga aaaagaaaaa gaagaagaag cattccccta     3480



agaacttgct gcttaatttt gtcactattg aagaaactaa ggcagatgat gttgacagtg     3540



atggaaacag agtcacacta gaccttccta ttgatctaga agagcaaaca atgggaaagt     3600



acaattgggt aactacacct actactttca agcccgacag ccctgatttg gcccgacact     3660



acaaatctgc ctctccacag cctgccttcc aaattcagcc tgaaactccc ctgaattcga     3720



agcaccacat catccaagaa ctgcctctcg ataacacctt tgtggcctgt gactctatct     3780



ccaagtgttc ctcaagcagt tcagatccct acagcgtttc tgactgtggc tatccagtga     3840



cgaccttcga ggtacctgtg tccgtacaca ccagaccgcc aatgaaggag gttgtgcgat     3900



cttgcacccc catgaaagag tctacaacta tggagatctg gattcatccc caaccacagc     3960



ggaaatctga agggaaagtg gcaggaaagt cccagcggcg tgtcacattt cacctgccag     4020



aaggctctca ggaaagcagc agtgatggtg gactgggaga ccatgatgca ggcagcctta     4080



ccagcacatc tcatggcctg ccccttggct atcctcagga ggagtacttt gatcgtgcta     4140



cacccagcaa tcgcactgaa ggggatggca actccgatcc tgaatctact ttcatacctg     4200



gactaaagaa agctgcagaa ataactgttc aaccaactgt ggaagaggcc tctgacaact     4260



gcactcaaga atgtctcatc tatggccatt ctgatgcctg ctggatgccg gcatctctgg     4320



atcattccag ctcttcgcaa gcacaggcct ctgctctatg ccacagccca ccactgtcac     4380



aggcctctac tcagcaccac agcccacgag tgacacagac cattgctctc tgccacagcc     4440



ctccagtgac acagaccatc gcattgtgcc acagcccacc accgatacag gtgtctgctc     4500



tccaccacag tcctcctcta gtgcaggcta ctgcacttca ccacagccca ccatcagcac     4560



aggcctcagc cctctgctac agccctcctt tagcacaggc tgctgcaatc agccacagct     4620



ctcctctgcc acaggttatt gccctccatc gtagtcaggc ccaatcatca gtcagtttgc     4680



agcaaggttg ggtgcaaggt gctgatgggc tatgctctgt tgatcaggga gtgcaaggta     4740



gtgcaacatc tcagttttac accatgtctg aaagacttca tcccagtgat gattcaatta     4800



aagtcattcc tttgacaacc ttcactccac gccaacaggc cagaccgtcc agaggtgatt     4860



cccccattat ggaagaacat cccttgtaaa gctaaaatag ttacttcaaa ttttcagaaa     4920



agatgtatat agtcaaaatt taagatacaa ttccaatgag tattctgatt atcagatttg     4980



taaataacta tgtaaataga aacagatacc agaataaatc tacagctaga cccttagtca     5040



atagttaacc aaaaaattgc aatttgttta attcagaatg tgtatttaaa aagaaaagga     5100



atttaacaat ttgcatcccc ttgtacagta aggcttatca tgacagagcg cactatttct     5160



gatgtacagt attttttgtt gtttttatca tcatgtgcaa tattactgat ttgtttccat     5220



gctgattgtg tggaaccagt atgtagcaaa tggaaagcct agaaatatct tattttctaa     5280



gtttaccttt agtttaccta aacttttgtt cagataacgt taaaaggtat acgtactcta     5340



gccttttttt gggctttctt tttgattttt gtttgttgtt ttcagttttt ttgttgttgt     5400



tagtgagtct cccttcaaaa tacgcagtag gtagtgtaaa tactgcttgt ttgtgtctct     5460



ctgctgtcat gttttctacc ttattccaat actatattgt tgataaaatt tgtatataca     5520



ttttcaataa agaatatgta taaactgtac agatctagat ctacaaccta tttctctact     5580



ctttagtaga gttcgagaca cagaagtgca ataactgccc taattaagca actatttgtt     5640



aaaaagggcc tctttttact ttaatagttt agtgtaaagt acatcagaaa taaagctgta     5700



tctgccattt taagcctgta gtccattatt acttgggtct ttacttctgg gaatttgtat     5760



gtaacagcct agaaaattaa aaggaggtgg atgcatccaa agcacgagtc acttaaaata     5820



tcgacggtaa actactattt tgtagagaaa ctcaggaaga tttaaatgtt gatttgacag     5880



ctcaataggc tgttaccaaa gggtgttcag taaaaataac aaatacatgt aactgtagat     5940



aaaaccatat actaaatcta taagactaag ggatttttgt tattctagct caacttactg     6000



aagaaaacca ctaataacaa caagaatatc aggaaggaac ttttcaagaa atgtaattat     6060



aaatctacat caaacagaat tttaaggaaa aatgcagagg gagaaataag gcacatgact     6120



gcttcttgca gtcaacaaga aataccaata acacacacag aacaaaaacc atcaaaatct     6180



catatatgaa ataaaatata ttcttctaag caaagaaaca gtactattca tagaaaacat     6240



tagttttctt ctgttgtctg ttatttcctt cttgtatcct cttaactggc cattatcttg     6300



tatgtgcaca ttttataaat gtacagaaac atcaccaact taattttctt ccatagcaaa     6360



actgagaaaa taccttgttt cagtataaca ctaaaccaag agacaattga tgtttaatgg     6420



gggcggttgg ggtggggggg ggagtcaata tctcctattg attaacttag acatagattt     6480



tgtaatgtat aacttgatat ttaatttatg attaaactgt gtgtaaattt tgtaacataa     6540



actgtggtaa ttgcataatt tcattggtga ggatttccac tgaatattga gaaagtttct     6600



tttcatgtgc ccagcaggtt aagtagcgtt ttcagaatat acattattcc catccattgt     6660



aaagttcctt aagtcatatt tgactgggcg tgcagaataa cttcttaact tttaactatc     6720



agagtttgat taataaaatt aattaatgtt ttttctcctt cgtgttgtta atgttccaag     6780



ggatttggag catactggtt ttccaggtgc atgtgaatcc cgaaggactg atgatatttg     6840



aatgtttatt aaattattat catacaaatg tgttgatatt gtggctattg ttgatgttga     6900



aaattttaaa cttggggaag attaagaaaa gaaccaatag tgacaaaaat cagtgcttcc     6960



agtagatttt agaacattct ttgcctcaaa aaacctgcaa agatgatgtg agattttttc     7020



ttgtgtttta attattttca cattttctct ctgcaaaact ttagttttct gatgatctac     7080



acacacacac acacacacac gtgcacacac acacacattt aaatgatata aaaagaagag     7140



gttgaaagat tattaaataa cttatcaggc atctcaatgg ttactatcta tgttagtgaa     7200



aatcaaatag gactcaaagt tggatatttg ggatttttct tctgacagta taatttattg     7260



agttactagg gaggttctta aatcctcata tctggaaact tgtgacgttt tgacaccttt     7320



cctatagatg atataggaat gaaccaatac gcttttatta ccctttctaa ctctgatttt     7380



ataatcagac ttagattgtg tttagaatat taaatgactg ggcaccctct tcttggtttt     7440



taccagagag gctttgaatg gaagcaggct gagagtagcc aaagaggcaa ggggtattag     7500



cccagttatt ctcccctatg ccttccttct ctttctaagc gtccactagg tctggccttg     7560



gaaacctgtt acttctaggg cttcagatct gatgatatct ttttcatcac attacaagtt     7620



atttctctga ctgaatagac agtggtatag gttgacacag cacacaagtg gctattgtga     7680



tgtatgatgt atgtagtcct acaactgcaa aacgtcttac tgaaccaaca atcaaaaaat     7740



ggttctgttt taaaaaggat tttgtttgat ttgaaattaa aacttcaagc tgaatgactt     7800



atatgagaat aatacgttca atcaaagtag ttattctatt ttgtgtccat attccattag     7860



attgtgatta ttaattttct agctatggta ttactatatc acacttgtga gtatgtattc     7920



aaatactaag tatcttatat gctacgtgca tacacattct tttcttaaac tttacctgtg     7980



ttttaactaa tattgtgtca gtgtattaaa aattagcttt tacatatgat atctacaatg     8040



taataaattt agagagtaat tttgtgtatt cttatttact taacatttta cttttaatta     8100



tgtaaatttg gttagaaaat aataataaat ggttagtgct attgtgtaat ggtagcagtt     8160



acaaagagcc tctgccttcc caaactaata tttatcacac atggtcatta aatgggaaaa     8220



aaatagacta aacaaatcac aaattgttca gttcttaaaa tgtaattatg tcacacacac     8280



aaaaaatcct tttcaatcct gagaaaatta aaggcgtttt actcacatgg ctatttcaac     8340



attagttttt tttgtttgtt tctttttcat ggtattactg aaggtgtgta tactccctaa     8400



tacacattta tgaaaatcta cttgtttagg cttttattta tactcttctg atttatattt     8460



tttattataa ttattatttc ttatctttct tcttttatat tttttggaaa ccaaatttat     8520



agttagttta ggtaaacttt ttattatgac cattagaaac tattttgaat gcttccaact     8580



ggctcaattg gccgggaaaa catgggagca agagaagctg aaatatattt ctgcaagaac     8640



ctttctatat tatgtgccaa ttaccacacc agatcaattt tatgcagagg ccttaaaata     8700



ttctttcaca gtagctttct tacactaacc gtcatgtgct tttagtaaat atgattttta     8760



aaagcagttc aagttgacaa cagcagaaac agtaacaaaa aaatctgctc agaaaaatgt     8820



atgtgcacaa ataaaaaaaa ttaatggcaa ttgtttagtg attgtaagtg atacttttta     8880



aagagtaaac tgtgtgaaat ttatactatc cctgcttaaa atattaagat ttttatgaaa     8940



tatgtattta tgtttgtatt gtgggaagat tcctcctctg tgatatcata cagcatctga     9000



aagtgaacag tatcccaaag cagttccaac catgctttgg aagtaagaag gttgactatt     9060



gtatggccaa ggatggcagt atgtaatcca gaagcaaact tgtattaatt gttctatttc     9120



aggttctgta ttgcatgttt tcttattaat atatattaat aaaagttatg agaaat         9176





<210>  215

<211>  1347

<212>  PRT

<213>  Homo sapiens



<400>  215



Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys 

1               5                   10                  15      





Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu 

            20                  25                  30          





Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn 

        35                  40                  45              





Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys 

    50                  55                  60                  





Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp 

65                  70                  75                  80  





Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu 

                85                  90                  95      





Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val 

            100                 105                 110         





Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu 

        115                 120                 125             





Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile 

    130                 135                 140                 





Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu 

145                 150                 155                 160 





Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr 

                165                 170                 175     





Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr 

            180                 185                 190         





Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp 

        195                 200                 205             





Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly 

    210                 215                 220                 





Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr 

225                 230                 235                 240 





Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val 

                245                 250                 255     





Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His 

            260                 265                 270         





Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe 

        275                 280                 285             





Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala 

    290                 295                 300                 





Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr 

305                 310                 315                 320 





Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro 

                325                 330                 335     





Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val 

            340                 345                 350         





Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val 

        355                 360                 365             





Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr 

    370                 375                 380                 





Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr 

385                 390                 395                 400 





Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe 

                405                 410                 415     





Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr 

            420                 425                 430         





Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln 

        435                 440                 445             





Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro 

    450                 455                 460                 





Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser 

465                 470                 475                 480 





Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly 

                485                 490                 495     





Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu 

            500                 505                 510         





Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu 

        515                 520                 525             





Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp 

    530                 535                 540                 





Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile 

545                 550                 555                 560 





Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn 

                565                 570                 575     





Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile 

            580                 585                 590         





Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser 

        595                 600                 605             





Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val 

    610                 615                 620                 





Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr 

625                 630                 635                 640 





Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser 

                645                 650                 655     





Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val 

            660                 665                 670         





Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser 

        675                 680                 685             





Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp 

    690                 695                 700                 





Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr 

705                 710                 715                 720 





Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met 

                725                 730                 735     





Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys 

            740                 745                 750         





Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val 

        755                 760                 765             





Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu 

    770                 775                 780                 





Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile 

785                 790                 795                 800 





Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala 

                805                 810                 815     





Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala 

            820                 825                 830         





Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn 

        835                 840                 845             





Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met 

    850                 855                 860                 





Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn 

865                 870                 875                 880 





Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val 

                885                 890                 895     





Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu 

            900                 905                 910         





Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe 

        915                 920                 925             





Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro 

    930                 935                 940                 





Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His 

945                 950                 955                 960 





His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp 

                965                 970                 975     





Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser 

            980                 985                 990         





Asp Cys Gly Tyr Pro Val Thr Thr  Phe Glu Val Pro Val  Ser Val His 

        995                 1000                 1005             





Thr Arg  Pro Pro Met Lys Glu  Val Val Arg Ser Cys  Thr Pro Met 

    1010                 1015                 1020             





Lys Glu  Ser Thr Thr Met Glu  Ile Trp Ile His Pro  Gln Pro Gln 

    1025                 1030                 1035             





Arg Lys  Ser Glu Gly Lys Val  Ala Gly Lys Ser Gln  Arg Arg Val 

    1040                 1045                 1050             





Thr Phe  His Leu Pro Glu Gly  Ser Gln Glu Ser Ser  Ser Asp Gly 

    1055                 1060                 1065             





Gly Leu  Gly Asp His Asp Ala  Gly Ser Leu Thr Ser  Thr Ser His 

    1070                 1075                 1080             





Gly Leu  Pro Leu Gly Tyr Pro  Gln Glu Glu Tyr Phe  Asp Arg Ala 

    1085                 1090                 1095             





Thr Pro  Ser Asn Arg Thr Glu  Gly Asp Gly Asn Ser  Asp Pro Glu 

    1100                 1105                 1110             





Ser Thr  Phe Ile Pro Gly Leu  Lys Lys Ala Ala Glu  Ile Thr Val 

    1115                 1120                 1125             





Gln Pro  Thr Val Glu Glu Ala  Ser Asp Asn Cys Thr  Gln Glu Cys 

    1130                 1135                 1140             





Leu Ile  Tyr Gly His Ser Asp  Ala Cys Trp Met Pro  Ala Ser Leu 

    1145                 1150                 1155             





Asp His  Ser Ser Ser Ser Gln  Ala Gln Ala Ser Ala  Leu Cys His 

    1160                 1165                 1170             





Ser Pro  Pro Leu Ser Gln Ala  Ser Thr Gln His His  Ser Pro Arg 

    1175                 1180                 1185             





Val Thr  Gln Thr Ile Ala Leu  Cys His Ser Pro Pro  Val Thr Gln 

    1190                 1195                 1200             





Thr Ile  Ala Leu Cys His Ser  Pro Pro Pro Ile Gln  Val Ser Ala 

    1205                 1210                 1215             





Leu His  His Ser Pro Pro Leu  Val Gln Ala Thr Ala  Leu His His 

    1220                 1225                 1230             





Ser Pro  Pro Ser Ala Gln Ala  Ser Ala Leu Cys Tyr  Ser Pro Pro 

    1235                 1240                 1245             





Leu Ala  Gln Ala Ala Ala Ile  Ser His Ser Ser Pro  Leu Pro Gln 

    1250                 1255                 1260             





Val Ile  Ala Leu His Arg Ser  Gln Ala Gln Ser Ser  Val Ser Leu 

    1265                 1270                 1275             





Gln Gln  Gly Trp Val Gln Gly  Ala Asp Gly Leu Cys  Ser Val Asp 

    1280                 1285                 1290             





Gln Gly  Val Gln Gly Ser Ala  Thr Ser Gln Phe Tyr  Thr Met Ser 

    1295                 1300                 1305             





Glu Arg  Leu His Pro Ser Asp  Asp Ser Ile Lys Val  Ile Pro Leu 

    1310                 1315                 1320             





Thr Thr  Phe Thr Pro Arg Gln  Gln Ala Arg Pro Ser  Arg Gly Asp 

    1325                 1330                 1335             





Ser Pro  Ile Met Glu Glu His  Pro Leu 

    1340                 1345         





<210>  216

<211>  9146

<212>  DNA

<213>  Homo sapiens



<400>  216

ctggtggtcc agtacctcca aagatatgga atacactcct gaaatatcct gaaaactttt       60



ttttttcaga atcctttaat aagcagttat gtcaatctga aagttgctta cttgtacttt      120



atattaatag ctattcttgt ttttcttatc caaagaaaaa tcctctaatc cccttttcac      180



atgatagttg ttaccatgtt taggcattag tcacatcaac ccctctcctc tcccaaactt      240



ctcttcttca aatcaaactt tattagtccc tcctttataa tgattccttg cctcgtttta      300



tccagatcaa ttttttttca ctttgatgcc cagagctgaa gaaatggact actgtataaa      360



ttattcattg ccaagagaat aattgcattt taaacccata ttataacaaa gaataatgat      420



tatattttgt gatttgtaac aaataccctt tattttccct taactattga attaaatatt      480



ttaattattt gtattctctt taactatctt ggtatattaa agtattatct tttatatatt      540



tatcaatggt ggacactttt ataggtactc tgtgtcattt ttgatactgt aggtatctta      600



tttcatttat ctttattctt aatgtacgaa ttcataatat ttgattcaga acaaatttat      660



cactaattaa cagagtgtca attatgctaa catctcattt actgatttta atttaaaaca      720



gtttttgtta acatgcatgt ttagggttgg cttcttaata atttcttctt cctcttctct      780



ctctcctctt cttttggtca gtgttgtgcg ggttaataca acaaactgta acaagtgtac      840



ctggtatgga cttgttgtcc gggacgtaca ttttcgcggt cctgctagca tgcgtggtgt      900



tccactctgg cgcccaggag aaaaactaca ccatccgaga agaaatgcca gaaaacgtcc      960



tgataggcga cttgttgaaa gaccttaact tgtcgctgat tccaaacaag tccttgacaa     1020



ctgctatgca gttcaagcta gtgtacaaga ccggagatgt gccactgatt cgaattgaag     1080



aggatactgg tgagatcttc actactggcg ctcgcattga tcgtgagaaa ttatgtgctg     1140



gtatcccaag ggatgagcat tgcttttatg aagtggaggt tgccattttg ccggatgaaa     1200



tatttagact ggttaagata cgttttctga tagaagatat aaatgataat gcaccattgt     1260



tcccagcaac agttatcaac atatcaattc cagagaactc ggctataaac tctaaatata     1320



ctctcccagc ggctgttgat cctgacgtag gaataaacgg agttcaaaac tacgaactaa     1380



ttaagagtca aaacattttt ggcctcgatg tcattgaaac accagaagga gacaagatgc     1440



cacaactgat tgttcaaaag gagttagata gggaagagaa ggatacctac gtgatgaaag     1500



taaaggttga agatggtggc tttcctcaaa gatccagtac tgctattttg caagtgagtg     1560



ttactgatac aaatgacaac cacccagtct ttaaggagac agagattgaa gtcagtatac     1620



cagaaaatgc tcctgtaggc acttcagtga cacagctcca tgccacagat gctgacatag     1680



gtgaaaatgc caagatccac ttctctttca gcaatctagt ctccaacatt gccaggagat     1740



tatttcacct caatgccacc actggactta tcacaatcaa agaaccactg gatagggaag     1800



aaacaccaaa ccacaagtta ctggttttgg caagtgatgg tggattgatg ccagcaagag     1860



caatggtgct ggtaaatgtt acagatgtca atgataatgt cccatccatt gacataagat     1920



acatcgtcaa tcctgtcaat gacacagttg ttctttcaga aaatattcca ctcaacacca     1980



aaattgctct cataactgtg acggataagg atgcggacca taatggcagg gtgacatgct     2040



tcacagatca tgaaatccct ttcagattaa ggccagtatt cagtaatcag ttcctcctgg     2100



agactgcagc atatcttgac tatgagtcca caaaagaata tgccattaaa ttactggctg     2160



cagatgctgg caaacctcct ttgaatcagt cagcaatgct cttcatcaaa gtgaaagatg     2220



aaaatgacaa tgctccagtt ttcacccagt ctttcgtaac tgtttctatt cctgagaata     2280



actctcctgg catccagttg acgaaagtaa gtgcaatgga tgcagacagt gggcctaatg     2340



ctaagatcaa ttacctgcta ggccctgatg ctccacctga attcagcctg gattgtcgta     2400



caggcatgct gactgtagtg aagaaactag atagagaaaa agaggataaa tatttattca     2460



caattctggc aaaagataac ggggtaccac ccttaaccag caatgtcaca gtctttgtaa     2520



gcattattga tcagaatgac aatagcccag ttttcactca caatgaatac aacttctatg     2580



tcccagaaaa ccttccaagg catggtacag taggactaat cactgtaact gatcctgatt     2640



atggagacaa ttctgcagtt acgctctcca ttttagatga gaatgatgac ttcaccattg     2700



attcacaaac tggtgtcatc cgaccaaata tttcatttga tagagaaaaa caagaatctt     2760



acactttcta tgtaaaggct gaggatggtg gtagagtatc acgttcttca agtgccaaag     2820



taaccataaa tgtggttgat gtcaatgaca acaaaccagt tttcattgtc cctccttcca     2880



actgttctta tgaattggtt ctaccgtcca ctaatccagg cacagtggtc tttcaggtaa     2940



ttgctgttga caatgacact ggcatgaatg cagaggttcg ttacagcatt gtaggaggaa     3000



acacaagaga tctgtttgca atcgaccaag aaacaggcaa cataacattg atggagaaat     3060



gtgatgttac agaccttggt ttacacagag tgttggtcaa agctaatgac ttaggacagc     3120



ctgattctct cttcagtgtt gtaattgtca atctgttcgt gaatgagtcg gtgaccaatg     3180



ctacactgat taatgaactg gtgcgcaaaa gcactgaagc accagtgacc ccaaatactg     3240



agatagctga tgtatcctca ccaactagtg actatgtcaa gatcctggtt gcagctgttg     3300



ctggcaccat aactgtcgtt gtagttattt tcatcactgc tgtagtaaga tgtcgccagg     3360



caccacacct taaggctgct cagaaaaaca agcagaattc tgaatgggct accccaaacc     3420



cagaaaacag gcagatgata atgatgaaga aaaagaaaaa gaagaagaag cattccccta     3480



agaacttgct gcttaatttt gtcactattg aagaaactaa ggcagatgat gttgacagtg     3540



atggaaacag agtcacacta gaccttccta ttgatctaga agagcaaaca atgggaaagt     3600



acaattgggt aactacacct actactttca agcccgacag ccctgatttg gcccgacact     3660



acaaatctgc ctctccacag cctgccttcc aaattcagcc tgaaactccc ctgaattcga     3720



agcaccacat catccaagaa ctgcctctcg ataacacctt tgtggcctgt gactctatct     3780



ccaagtgttc ctcaagcagt tcagatccct acagcgtttc tgactgtggc tatccagtga     3840



cgaccttcga ggtacctgtg tccgtacaca ccagaccgcc aatgaaggag gttgtgcgat     3900



cttgcacccc catgaaagag tctacaacta tggagatctg gattcatccc caaccacagt     3960



cccagcggcg tgtcacattt cacctgccag aaggctctca ggaaagcagc agtgatggtg     4020



gactgggaga ccatgatgca ggcagcctta ccagcacatc tcatggcctg ccccttggct     4080



atcctcagga ggagtacttt gatcgtgcta cacccagcaa tcgcactgaa ggggatggca     4140



actccgatcc tgaatctact ttcatacctg gactaaagaa agctgcagaa ataactgttc     4200



aaccaactgt ggaagaggcc tctgacaact gcactcaaga atgtctcatc tatggccatt     4260



ctgatgcctg ctggatgccg gcatctctgg atcattccag ctcttcgcaa gcacaggcct     4320



ctgctctatg ccacagccca ccactgtcac aggcctctac tcagcaccac agcccacgag     4380



tgacacagac cattgctctc tgccacagcc ctccagtgac acagaccatc gcattgtgcc     4440



acagcccacc accgatacag gtgtctgctc tccaccacag tcctcctcta gtgcaggcta     4500



ctgcacttca ccacagccca ccatcagcac aggcctcagc cctctgctac agccctcctt     4560



tagcacaggc tgctgcaatc agccacagct ctcctctgcc acaggttatt gccctccatc     4620



gtagtcaggc ccaatcatca gtcagtttgc agcaaggttg ggtgcaaggt gctgatgggc     4680



tatgctctgt tgatcaggga gtgcaaggta gtgcaacatc tcagttttac accatgtctg     4740



aaagacttca tcccagtgat gattcaatta aagtcattcc tttgacaacc ttcactccac     4800



gccaacaggc cagaccgtcc agaggtgatt cccccattat ggaagaacat cccttgtaaa     4860



gctaaaatag ttacttcaaa ttttcagaaa agatgtatat agtcaaaatt taagatacaa     4920



ttccaatgag tattctgatt atcagatttg taaataacta tgtaaataga aacagatacc     4980



agaataaatc tacagctaga cccttagtca atagttaacc aaaaaattgc aatttgttta     5040



attcagaatg tgtatttaaa aagaaaagga atttaacaat ttgcatcccc ttgtacagta     5100



aggcttatca tgacagagcg cactatttct gatgtacagt attttttgtt gtttttatca     5160



tcatgtgcaa tattactgat ttgtttccat gctgattgtg tggaaccagt atgtagcaaa     5220



tggaaagcct agaaatatct tattttctaa gtttaccttt agtttaccta aacttttgtt     5280



cagataacgt taaaaggtat acgtactcta gccttttttt gggctttctt tttgattttt     5340



gtttgttgtt ttcagttttt ttgttgttgt tagtgagtct cccttcaaaa tacgcagtag     5400



gtagtgtaaa tactgcttgt ttgtgtctct ctgctgtcat gttttctacc ttattccaat     5460



actatattgt tgataaaatt tgtatataca ttttcaataa agaatatgta taaactgtac     5520



agatctagat ctacaaccta tttctctact ctttagtaga gttcgagaca cagaagtgca     5580



ataactgccc taattaagca actatttgtt aaaaagggcc tctttttact ttaatagttt     5640



agtgtaaagt acatcagaaa taaagctgta tctgccattt taagcctgta gtccattatt     5700



acttgggtct ttacttctgg gaatttgtat gtaacagcct agaaaattaa aaggaggtgg     5760



atgcatccaa agcacgagtc acttaaaata tcgacggtaa actactattt tgtagagaaa     5820



ctcaggaaga tttaaatgtt gatttgacag ctcaataggc tgttaccaaa gggtgttcag     5880



taaaaataac aaatacatgt aactgtagat aaaaccatat actaaatcta taagactaag     5940



ggatttttgt tattctagct caacttactg aagaaaacca ctaataacaa caagaatatc     6000



aggaaggaac ttttcaagaa atgtaattat aaatctacat caaacagaat tttaaggaaa     6060



aatgcagagg gagaaataag gcacatgact gcttcttgca gtcaacaaga aataccaata     6120



acacacacag aacaaaaacc atcaaaatct catatatgaa ataaaatata ttcttctaag     6180



caaagaaaca gtactattca tagaaaacat tagttttctt ctgttgtctg ttatttcctt     6240



cttgtatcct cttaactggc cattatcttg tatgtgcaca ttttataaat gtacagaaac     6300



atcaccaact taattttctt ccatagcaaa actgagaaaa taccttgttt cagtataaca     6360



ctaaaccaag agacaattga tgtttaatgg gggcggttgg ggtggggggg ggagtcaata     6420



tctcctattg attaacttag acatagattt tgtaatgtat aacttgatat ttaatttatg     6480



attaaactgt gtgtaaattt tgtaacataa actgtggtaa ttgcataatt tcattggtga     6540



ggatttccac tgaatattga gaaagtttct tttcatgtgc ccagcaggtt aagtagcgtt     6600



ttcagaatat acattattcc catccattgt aaagttcctt aagtcatatt tgactgggcg     6660



tgcagaataa cttcttaact tttaactatc agagtttgat taataaaatt aattaatgtt     6720



ttttctcctt cgtgttgtta atgttccaag ggatttggag catactggtt ttccaggtgc     6780



atgtgaatcc cgaaggactg atgatatttg aatgtttatt aaattattat catacaaatg     6840



tgttgatatt gtggctattg ttgatgttga aaattttaaa cttggggaag attaagaaaa     6900



gaaccaatag tgacaaaaat cagtgcttcc agtagatttt agaacattct ttgcctcaaa     6960



aaacctgcaa agatgatgtg agattttttc ttgtgtttta attattttca cattttctct     7020



ctgcaaaact ttagttttct gatgatctac acacacacac acacacacac gtgcacacac     7080



acacacattt aaatgatata aaaagaagag gttgaaagat tattaaataa cttatcaggc     7140



atctcaatgg ttactatcta tgttagtgaa aatcaaatag gactcaaagt tggatatttg     7200



ggatttttct tctgacagta taatttattg agttactagg gaggttctta aatcctcata     7260



tctggaaact tgtgacgttt tgacaccttt cctatagatg atataggaat gaaccaatac     7320



gcttttatta ccctttctaa ctctgatttt ataatcagac ttagattgtg tttagaatat     7380



taaatgactg ggcaccctct tcttggtttt taccagagag gctttgaatg gaagcaggct     7440



gagagtagcc aaagaggcaa ggggtattag cccagttatt ctcccctatg ccttccttct     7500



ctttctaagc gtccactagg tctggccttg gaaacctgtt acttctaggg cttcagatct     7560



gatgatatct ttttcatcac attacaagtt atttctctga ctgaatagac agtggtatag     7620



gttgacacag cacacaagtg gctattgtga tgtatgatgt atgtagtcct acaactgcaa     7680



aacgtcttac tgaaccaaca atcaaaaaat ggttctgttt taaaaaggat tttgtttgat     7740



ttgaaattaa aacttcaagc tgaatgactt atatgagaat aatacgttca atcaaagtag     7800



ttattctatt ttgtgtccat attccattag attgtgatta ttaattttct agctatggta     7860



ttactatatc acacttgtga gtatgtattc aaatactaag tatcttatat gctacgtgca     7920



tacacattct tttcttaaac tttacctgtg ttttaactaa tattgtgtca gtgtattaaa     7980



aattagcttt tacatatgat atctacaatg taataaattt agagagtaat tttgtgtatt     8040



cttatttact taacatttta cttttaatta tgtaaatttg gttagaaaat aataataaat     8100



ggttagtgct attgtgtaat ggtagcagtt acaaagagcc tctgccttcc caaactaata     8160



tttatcacac atggtcatta aatgggaaaa aaatagacta aacaaatcac aaattgttca     8220



gttcttaaaa tgtaattatg tcacacacac aaaaaatcct tttcaatcct gagaaaatta     8280



aaggcgtttt actcacatgg ctatttcaac attagttttt tttgtttgtt tctttttcat     8340



ggtattactg aaggtgtgta tactccctaa tacacattta tgaaaatcta cttgtttagg     8400



cttttattta tactcttctg atttatattt tttattataa ttattatttc ttatctttct     8460



tcttttatat tttttggaaa ccaaatttat agttagttta ggtaaacttt ttattatgac     8520



cattagaaac tattttgaat gcttccaact ggctcaattg gccgggaaaa catgggagca     8580



agagaagctg aaatatattt ctgcaagaac ctttctatat tatgtgccaa ttaccacacc     8640



agatcaattt tatgcagagg ccttaaaata ttctttcaca gtagctttct tacactaacc     8700



gtcatgtgct tttagtaaat atgattttta aaagcagttc aagttgacaa cagcagaaac     8760



agtaacaaaa aaatctgctc agaaaaatgt atgtgcacaa ataaaaaaaa ttaatggcaa     8820



ttgtttagtg attgtaagtg atacttttta aagagtaaac tgtgtgaaat ttatactatc     8880



cctgcttaaa atattaagat ttttatgaaa tatgtattta tgtttgtatt gtgggaagat     8940



tcctcctctg tgatatcata cagcatctga aagtgaacag tatcccaaag cagttccaac     9000



catgctttgg aagtaagaag gttgactatt gtatggccaa ggatggcagt atgtaatcca     9060



gaagcaaact tgtattaatt gttctatttc aggttctgta ttgcatgttt tcttattaat     9120



atatattaat aaaagttatg agaaat                                          9146





<210>  217

<211>  1337

<212>  PRT

<213>  Homo sapiens



<400>  217



Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys 

1               5                   10                  15      





Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu 

            20                  25                  30          





Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn 

        35                  40                  45              





Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys 

    50                  55                  60                  





Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp 

65                  70                  75                  80  





Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu 

                85                  90                  95      





Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val 

            100                 105                 110         





Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu 

        115                 120                 125             





Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile 

    130                 135                 140                 





Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu 

145                 150                 155                 160 





Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr 

                165                 170                 175     





Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr 

            180                 185                 190         





Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp 

        195                 200                 205             





Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly 

    210                 215                 220                 





Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr 

225                 230                 235                 240 





Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val 

                245                 250                 255     





Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His 

            260                 265                 270         





Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe 

        275                 280                 285             





Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala 

    290                 295                 300                 





Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr 

305                 310                 315                 320 





Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro 

                325                 330                 335     





Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val 

            340                 345                 350         





Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val 

        355                 360                 365             





Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr 

    370                 375                 380                 





Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr 

385                 390                 395                 400 





Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe 

                405                 410                 415     





Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr 

            420                 425                 430         





Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln 

        435                 440                 445             





Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro 

    450                 455                 460                 





Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser 

465                 470                 475                 480 





Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly 

                485                 490                 495     





Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu 

            500                 505                 510         





Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu 

        515                 520                 525             





Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp 

    530                 535                 540                 





Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile 

545                 550                 555                 560 





Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn 

                565                 570                 575     





Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile 

            580                 585                 590         





Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser 

        595                 600                 605             





Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val 

    610                 615                 620                 





Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr 

625                 630                 635                 640 





Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser 

                645                 650                 655     





Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val 

            660                 665                 670         





Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser 

        675                 680                 685             





Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp 

    690                 695                 700                 





Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr 

705                 710                 715                 720 





Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met 

                725                 730                 735     





Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys 

            740                 745                 750         





Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val 

        755                 760                 765             





Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu 

    770                 775                 780                 





Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile 

785                 790                 795                 800 





Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala 

                805                 810                 815     





Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala 

            820                 825                 830         





Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn 

        835                 840                 845             





Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met 

    850                 855                 860                 





Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn 

865                 870                 875                 880 





Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val 

                885                 890                 895     





Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu 

            900                 905                 910         





Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe 

        915                 920                 925             





Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro 

    930                 935                 940                 





Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His 

945                 950                 955                 960 





His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp 

                965                 970                 975     





Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser 

            980                 985                 990         





Asp Cys Gly Tyr Pro Val Thr Thr  Phe Glu Val Pro Val  Ser Val His 

        995                 1000                 1005             





Thr Arg  Pro Pro Met Lys Glu  Val Val Arg Ser Cys  Thr Pro Met 

    1010                 1015                 1020             





Lys Glu  Ser Thr Thr Met Glu  Ile Trp Ile His Pro  Gln Pro Gln 

    1025                 1030                 1035             





Ser Gln  Arg Arg Val Thr Phe  His Leu Pro Glu Gly  Ser Gln Glu 

    1040                 1045                 1050             





Ser Ser  Ser Asp Gly Gly Leu  Gly Asp His Asp Ala  Gly Ser Leu 

    1055                 1060                 1065             





Thr Ser  Thr Ser His Gly Leu  Pro Leu Gly Tyr Pro  Gln Glu Glu 

    1070                 1075                 1080             





Tyr Phe  Asp Arg Ala Thr Pro  Ser Asn Arg Thr Glu  Gly Asp Gly 

    1085                 1090                 1095             





Asn Ser  Asp Pro Glu Ser Thr  Phe Ile Pro Gly Leu  Lys Lys Ala 

    1100                 1105                 1110             





Ala Glu  Ile Thr Val Gln Pro  Thr Val Glu Glu Ala  Ser Asp Asn 

    1115                 1120                 1125             





Cys Thr  Gln Glu Cys Leu Ile  Tyr Gly His Ser Asp  Ala Cys Trp 

    1130                 1135                 1140             





Met Pro  Ala Ser Leu Asp His  Ser Ser Ser Ser Gln  Ala Gln Ala 

    1145                 1150                 1155             





Ser Ala  Leu Cys His Ser Pro  Pro Leu Ser Gln Ala  Ser Thr Gln 

    1160                 1165                 1170             





His His  Ser Pro Arg Val Thr  Gln Thr Ile Ala Leu  Cys His Ser 

    1175                 1180                 1185             





Pro Pro  Val Thr Gln Thr Ile  Ala Leu Cys His Ser  Pro Pro Pro 

    1190                 1195                 1200             





Ile Gln  Val Ser Ala Leu His  His Ser Pro Pro Leu  Val Gln Ala 

    1205                 1210                 1215             





Thr Ala  Leu His His Ser Pro  Pro Ser Ala Gln Ala  Ser Ala Leu 

    1220                 1225                 1230             





Cys Tyr  Ser Pro Pro Leu Ala  Gln Ala Ala Ala Ile  Ser His Ser 

    1235                 1240                 1245             





Ser Pro  Leu Pro Gln Val Ile  Ala Leu His Arg Ser  Gln Ala Gln 

    1250                 1255                 1260             





Ser Ser  Val Ser Leu Gln Gln  Gly Trp Val Gln Gly  Ala Asp Gly 

    1265                 1270                 1275             





Leu Cys  Ser Val Asp Gln Gly  Val Gln Gly Ser Ala  Thr Ser Gln 

    1280                 1285                 1290             





Phe Tyr  Thr Met Ser Glu Arg  Leu His Pro Ser Asp  Asp Ser Ile 

    1295                 1300                 1305             





Lys Val  Ile Pro Leu Thr Thr  Phe Thr Pro Arg Gln  Gln Ala Arg 

    1310                 1315                 1320             





Pro Ser  Arg Gly Asp Ser Pro  Ile Met Glu Glu His  Pro Leu 

    1325                 1330                 1335         





<210>  218

<211>  2344

<212>  DNA

<213>  Homo sapiens



<400>  218

ggcccgcccc cgcgcggccg cccctcggac caccggactg gcctggggcg ggacgtgggc       60



gcgggggcgc ggcgtgcggc acgctgcagg gctgaagcgg cggcggcggt ggggactgca      120



cgtagcccgg cgctcggcat ggctctcctg gtgctcggtc tggtgagctg taccttcttt      180



ctggcagtga atggtctgta ttcctctagt gatgatgtga tcgaattaac tccatcgaat      240



ttcaaccgag aagttattca gagtgatagt ttgtggcttg tagaattcta tgctccatgg      300



tgtggtcact gtcaaagatt aacaccagaa tggaagaaag cagcaactgc attaaaagat      360



gttgtcaaag ttggtgcagt tgatgcagat aagcatcatt ccctaggagg tcagtatggt      420



gttcagggat ttcctaccat taagattttt ggatccaaca aaaacagacc agaagattac      480



caaggtggca gaactggtga agccattgta gatgctgcgc tgagtgctct gcgccagctc      540



gtgaaggatc gcctcggggg acggagcgga ggatacagtt ctggaaaaca aggcagaagt      600



gatagttcaa gtaagaagga tgtgattgag ctgacagacg acagctttga taagaatgtt      660



ctggacagtg aagatgtttg gatggttgag ttctatgctc cttggtgtgg acactgcaaa      720



aacctagagc cagagtgggc tgccgcagct tcagaagtaa aagagcagac gaaaggaaaa      780



gtgaaactgg cagctgtgga tgctacagtc aatcaggttc tggcctcccg atacgggatt      840



agaggatttc ctacaatcaa gatatttcag aaaggcgagt ctcctgtgga ttatgacggt      900



gggcggacaa gatccgacat cgtgtcccgg gcccttgatt tgttttctga taacgcccca      960



cctcctgagc tgcttgagat tatcaacgag gacattgcca agaggacgtg tgaggagcac     1020



cagctctgtg ttgtggctgt gctgccccat atccttgata ctggagctgc aggcagaaat     1080



tcttatctgg aagttcttct gaagttggca gacaaataca aaaagaaaat gtgggggtgg     1140



ctgtggacag aagctggagc ccagtctgaa cttgagaccg cgttggggat tggagggttt     1200



gggtaccccg ccatggccgc catcaatgca cgcaagatga aatttgctct gctaaaaggc     1260



tccttcagtg agcaaggcat caacgagttt ctcagggagc tctcttttgg gcgtggctcc     1320



acggcacctg taggaggcgg ggctttccct accatcgttg agagagagcc ttgggacggc     1380



agggatggcg agcttcccgt ggaggatgac attgacctca gtgatgtgga gcttgatgac     1440



ttagggaaag atgagttgtg agagccacaa cagaggcttc agaccatttt cttttcttgg     1500



gagccagtgg atttttccag cagtgaaggg acattctcta cactcagatg actctaccag     1560



tggcctttta accaagaagt agtacttgat tggtcatttg aaaacactgc aacagtgaac     1620



ttttgcatct caagaaaaca ttgaaaaatt ctatgaattg ttgtagccgg tgaattgagt     1680



cgtattctgt cacataatat tttgaagaaa acttggctgt cgaaacattt ttctctctga     1740



ctgctgcttg aatgttcttg gaggctgttt cttatgtatg ggtttttttt aatgtgatcc     1800



cttcatttga atattaatgg ctttttccat taaagaataa aatattttgg acaatgccga     1860



taaatgtatg aagttagtat ccacatcata aattcagagt gatgtttagc agtaaatcaa     1920



tattttgaag tgatacacag atgtctttcc tccccacaaa cttttttaaa caaaaaacaa     1980



gacctctttt ctttagatgg tgccacctat gcccaccaca acagagattt tacatggaaa     2040



ccgggctcag tgagaactga tttcctgccc aatatttgtc tttgggctgt ctctagtgac     2100



taattattaa ggaatctagc tggttataca gttcaaggct ttctatgttg ttaatgaacc     2160



tcaaaatagc cgttaagaca tgaaatacag cagcaggtta ccaatgcgaa caggtagttc     2220



gcatttatgt aaaacattca gaaaatgaag ttttgaattt gttggaacat tcaaaggact     2280



tgagagcatt ttattgtaac ttaaaaaaat aaatacaact gtcactaaaa aaaaaaaaaa     2340



aaaa                                                                  2344





<210>  219

<211>  440

<212>  PRT

<213>  Homo sapiens



<400>  219



Met Ala Leu Leu Val Leu Gly Leu Val Ser Cys Thr Phe Phe Leu Ala 

1               5                   10                  15      





Val Asn Gly Leu Tyr Ser Ser Ser Asp Asp Val Ile Glu Leu Thr Pro 

            20                  25                  30          





Ser Asn Phe Asn Arg Glu Val Ile Gln Ser Asp Ser Leu Trp Leu Val 

        35                  40                  45              





Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln Arg Leu Thr Pro Glu 

    50                  55                  60                  





Trp Lys Lys Ala Ala Thr Ala Leu Lys Asp Val Val Lys Val Gly Ala 

65                  70                  75                  80  





Val Asp Ala Asp Lys His His Ser Leu Gly Gly Gln Tyr Gly Val Gln 

                85                  90                  95      





Gly Phe Pro Thr Ile Lys Ile Phe Gly Ser Asn Lys Asn Arg Pro Glu 

            100                 105                 110         





Asp Tyr Gln Gly Gly Arg Thr Gly Glu Ala Ile Val Asp Ala Ala Leu 

        115                 120                 125             





Ser Ala Leu Arg Gln Leu Val Lys Asp Arg Leu Gly Gly Arg Ser Gly 

    130                 135                 140                 





Gly Tyr Ser Ser Gly Lys Gln Gly Arg Ser Asp Ser Ser Ser Lys Lys 

145                 150                 155                 160 





Asp Val Ile Glu Leu Thr Asp Asp Ser Phe Asp Lys Asn Val Leu Asp 

                165                 170                 175     





Ser Glu Asp Val Trp Met Val Glu Phe Tyr Ala Pro Trp Cys Gly His 

            180                 185                 190         





Cys Lys Asn Leu Glu Pro Glu Trp Ala Ala Ala Ala Ser Glu Val Lys 

        195                 200                 205             





Glu Gln Thr Lys Gly Lys Val Lys Leu Ala Ala Val Asp Ala Thr Val 

    210                 215                 220                 





Asn Gln Val Leu Ala Ser Arg Tyr Gly Ile Arg Gly Phe Pro Thr Ile 

225                 230                 235                 240 





Lys Ile Phe Gln Lys Gly Glu Ser Pro Val Asp Tyr Asp Gly Gly Arg 

                245                 250                 255     





Thr Arg Ser Asp Ile Val Ser Arg Ala Leu Asp Leu Phe Ser Asp Asn 

            260                 265                 270         





Ala Pro Pro Pro Glu Leu Leu Glu Ile Ile Asn Glu Asp Ile Ala Lys 

        275                 280                 285             





Arg Thr Cys Glu Glu His Gln Leu Cys Val Val Ala Val Leu Pro His 

    290                 295                 300                 





Ile Leu Asp Thr Gly Ala Ala Gly Arg Asn Ser Tyr Leu Glu Val Leu 

305                 310                 315                 320 





Leu Lys Leu Ala Asp Lys Tyr Lys Lys Lys Met Trp Gly Trp Leu Trp 

                325                 330                 335     





Thr Glu Ala Gly Ala Gln Ser Glu Leu Glu Thr Ala Leu Gly Ile Gly 

            340                 345                 350         





Gly Phe Gly Tyr Pro Ala Met Ala Ala Ile Asn Ala Arg Lys Met Lys 

        355                 360                 365             





Phe Ala Leu Leu Lys Gly Ser Phe Ser Glu Gln Gly Ile Asn Glu Phe 

    370                 375                 380                 





Leu Arg Glu Leu Ser Phe Gly Arg Gly Ser Thr Ala Pro Val Gly Gly 

385                 390                 395                 400 





Gly Ala Phe Pro Thr Ile Val Glu Arg Glu Pro Trp Asp Gly Arg Asp 

                405                 410                 415     





Gly Glu Leu Pro Val Glu Asp Asp Ile Asp Leu Ser Asp Val Glu Leu 

            420                 425                 430         





Asp Asp Leu Gly Lys Asp Glu Leu 

        435                 440 





<210>  220

<211>  4475

<212>  DNA

<213>  Homo sapiens



<400>  220

cgggtggctt tgcgggcgct cgcggtaagt ttgcgccaag tgcgcggcag ccgggacgca       60



gacggcggcg gcggcgagag gcggagcccg gggaccaccc cccatcaccc tccccccagt      120



cacctcacgt accacaacct cacgtaacct ctcacccccc ctccgatacc cccagccccg      180



ggatggcagc gcccgccagc cttcccggcc ggaccggctg tcgccagtgc cggctttagc      240



ctgtgggact aggccccgcc gaggcctgac ccccggagcc gggacccact gtgcagccag      300



cagccgggcc gggactgagg ggccgctccc ccctcgcggc ccgtcgggag gacgctgtcg      360



tcccggggac tgggggccgg ggggtggggg ggagccaggg cgaggaagtc gggacccgta      420



ttgggaaaaa agcggggccg gggtcaggag cgccccctcc cctcacctcc cccctccccc      480



cggggttggg ggggccggag cagagagcac ccagcccggg aggtggatga atgtgggaga      540



aaatggagac caagacgatc gtgtacgact tggacacatc aggggggctg atggagcaaa      600



tccaagctct gctggctccc cccaagacgg acgaggcaga aaagcgcagt cggaagcctg      660



agaaggagcc ccggagaagc ggcagggcca ccaaccacga cagctgcgat agctgcaagg      720



aaggtggaga tctcctgtgc tgcgaccact gcccggctgc cttccacctc cagtgctgta      780



accctccact gagtgaagaa atgttgcctc ctggagagtg gatgtgtcac cggtgcactg      840



ttcgccgaaa gaaacgagag cagaaaaagg agctgggtca tgtcaatgga ctggtggaca      900



aatctggcaa acggactaca tcccccagca gtgacactga cttgttggac agatcggcca      960



gcaaaactga actaaaggcc attgcccatg cccggatcct ggaaaggaga gccagcaggc     1020



ctggcacacc cacatccagc gccagcacag agactcccac ctctgagcag aatgatgtcg     1080



acgaagacat cattgacgtg gatgaggaac cagtagcagc ggagccagac tatgtgcagc     1140



cccagctgag gcggcccttt gagctgctga ttgctgccgc catggagcgg aaccccaccc     1200



aatttcagtt gcccaatgaa ctgacttgta ccactgcact accaggttct agcaagagga     1260



gaagaaagga ggaaaccaca gggaaaaatg ttaagaagac acagcatgaa ttagatcaca     1320



atggtctcgt tcccttaccc gtcaaagtct gcttcacgtg taacaggagt tgccgtgtgg     1380



ctcctctcat ccagtgtgac tattgccctc tcctgtttca catggattgc ctcgagccgc     1440



cgctcactgc catgcccctg ggcagatgga tgtgtccgaa tcacatcgaa catgtggtgc     1500



tgaaccagaa gaatatgaca ctgagcaatc ggtgccaggt gtttgatcgt ttccaggaca     1560



ccgtttcgca gcatgtcgtc aaagtggact tcctgaaccg aatccacaag aagcaccccc     1620



ctaaccggcg tgtgctccag tcggtcaaaa gaagaagctt gaaggttcct gatgctataa     1680



aatctcagta ccagtttcca ccccctctca ttgcacccgc ggccattcgg gacggggagc     1740



tgatctgcaa tgggatccct gaggaatcac agatgcacct tttgaactct gagcacttag     1800



ccacccaagc agagcagcaa gagtggctct gtagtgttgt tgcgctccag tgcagcatat     1860



tgaaacattt atctgctaag cagatgcctt cgcattggga ctctgaacag acagagaagg     1920



ctgatattaa gcctgttatt gtgactgaca gctcagtcac cacctccctg caaacagctg     1980



acaagacacc tacaccttcc cactacccct tgtcctgccc ctcagggatt agcacccaga     2040



attccctgag ctgctctcca ccccaccagt ccccagccct agaggacatc ggctgcagtt     2100



cttgtgcgga aaaatccaag aaaacccctt gtgggactgc caatgggcca gtgaacacag     2160



aggtgaaagc taatggccca cacctctaca gcagccctac tgattccacg gacccccggc     2220



gacttccagg cgctaacacc ccactaccag gcctctcaca ccggcaaggc tggccccggc     2280



ccctcacgcc accagcggct gggggccttc agaaccacac cgtcggcatc attgtgaaga     2340



cagagaatgc cactggcccc agctcttgcc cccagaggag tttggttcct gtcccaagcc     2400



tgcccccttc cattcccagc tcttgtgcca gcatcgagaa caccagcact ttgcaaagaa     2460



agactgtcca atcacagata ggacctccgt tgacagattc aaggccactg ggctcacccc     2520



caaacgccac ccgggtgctc actcccccgc aagcagcagg agatggtatc ttggccacaa     2580



cagccaacca acgattcagc tcaccagcgc catcgtcaga tggcaaggtc agccccggca     2640



cgttatccat aggaagcgct ttaaccgtac cctctttccc agccaactct actgccatgg     2700



tggacctcac caactcactt cgagcattta tggatgtcaa tggagaaatc gagataaata     2760



tgctggacga gaagctgatc aagtttctgg ccttgcagag aatacatcag cttttcccct     2820



cccgggtcca accttcaccg ggcagtgtcg ggacacatca gctggcttct ggagggcacc     2880



acatagaagt gcaaagaaag gaggtacagg cccgagctgt gttctacccc ctcttagggt     2940



tgggaggagc tgtgaacatg tgctatcgaa ccctctacat cgggacagga gctgacatgg     3000



atgtgtgcct tacaaactat ggtcactgta actacgtgtc cgggaaacat gcctgcatat     3060



tctacgatga gaataccaaa cattatgagc tgttaaacta cagtgagcat gggacaacgg     3120



tggacaatgt gctgtattca tgtgacttct cggagaagac cccgccaacc cccccaagca     3180



gtattgttgc caaagtgcag agtgtcatca ggcgccgccg gcaccagaaa caggacgaag     3240



agccaagtga ggaggcagcc atgatgagtt cccaggccca ggggccgcag cggagaccct     3300



gcaattgcaa agccagcagc tcgagcttga ttgggggcag tggggccggc tgggagggca     3360



cagccttact gcaccatggc agctacatca agctgggctg cctgcagttt gtcttcagca     3420



tcactgagtt tgcgaccaaa cagcccaaag gcgatgccag cctgctgcag gatggggtct     3480



tggccgagaa gctctctctc aagccccacc agggccctgt gctgcgctcc aactctgttc     3540



cttaggactg gcggctaccc cgccactggc ctgtacaccc acccaagact cctgcaatgc     3600



aaaaatgtac acaaaccaag cccgggtgtt ttctatactc taccagaaac ccttcaacta     3660



caatctttgc atgaaatgaa gaaaaccttt tgactgtttt ttaaaaatcc tttttctttt     3720



ctcaagttct agggggcatt tgcacatata tttgtactca acatttcatg ggaaagcggc     3780



agacctgagc tgaggaacag cgtgggcagg gagggaaaga cccagggtct ggacacttcc     3840



tccaacacaa aacccttccc cacccacctc ctgctccctc cccctcgccc accattgtaa     3900



aataatcaga aacttgttct attttgtggc agtgacaata gttttatatt aaaagaaaaa     3960



atacagtttt catacagcaa aatctataca atatcattgt tttatttaat ataaagatcg     4020



ctacccacct tccttccatg gttcccaccc tccacgttat tttccctttc tgcagcggtt     4080



gcactacagg tagctactgt gtattatgga caaatgagaa atgaattctt tttctggctg     4140



tccatctatt ttatttcaaa taaggaaaag tgtatttgga ttttgtgtaa atacatctag     4200



tgatgacatt ttttcaatgt ttttaaaaac cgtgtacagt actacatgtg gtagagcgtt     4260



ttctcaaatt gtctattgta gcaaaaatgt ttttgtcgta aacctgtttt gtctcctttt     4320



tttgttctct tgccacttct ctcctcttcc tcctgcccct ggttccctcc tctcctccca     4380



cccccacaac cagtaccaat gtacatagta attgtaatgt tttagacttt acagaaactt     4440



tcctgtattc tgtatataaa aaacaaaaat acttc                                4475





<210>  221

<211>  1004

<212>  PRT

<213>  Homo sapiens



<400>  221



Met Trp Glu Lys Met Glu Thr Lys Thr Ile Val Tyr Asp Leu Asp Thr 

1               5                   10                  15      





Ser Gly Gly Leu Met Glu Gln Ile Gln Ala Leu Leu Ala Pro Pro Lys 

            20                  25                  30          





Thr Asp Glu Ala Glu Lys Arg Ser Arg Lys Pro Glu Lys Glu Pro Arg 

        35                  40                  45              





Arg Ser Gly Arg Ala Thr Asn His Asp Ser Cys Asp Ser Cys Lys Glu 

    50                  55                  60                  





Gly Gly Asp Leu Leu Cys Cys Asp His Cys Pro Ala Ala Phe His Leu 

65                  70                  75                  80  





Gln Cys Cys Asn Pro Pro Leu Ser Glu Glu Met Leu Pro Pro Gly Glu 

                85                  90                  95      





Trp Met Cys His Arg Cys Thr Val Arg Arg Lys Lys Arg Glu Gln Lys 

            100                 105                 110         





Lys Glu Leu Gly His Val Asn Gly Leu Val Asp Lys Ser Gly Lys Arg 

        115                 120                 125             





Thr Thr Ser Pro Ser Ser Asp Thr Asp Leu Leu Asp Arg Ser Ala Ser 

    130                 135                 140                 





Lys Thr Glu Leu Lys Ala Ile Ala His Ala Arg Ile Leu Glu Arg Arg 

145                 150                 155                 160 





Ala Ser Arg Pro Gly Thr Pro Thr Ser Ser Ala Ser Thr Glu Thr Pro 

                165                 170                 175     





Thr Ser Glu Gln Asn Asp Val Asp Glu Asp Ile Ile Asp Val Asp Glu 

            180                 185                 190         





Glu Pro Val Ala Ala Glu Pro Asp Tyr Val Gln Pro Gln Leu Arg Arg 

        195                 200                 205             





Pro Phe Glu Leu Leu Ile Ala Ala Ala Met Glu Arg Asn Pro Thr Gln 

    210                 215                 220                 





Phe Gln Leu Pro Asn Glu Leu Thr Cys Thr Thr Ala Leu Pro Gly Ser 

225                 230                 235                 240 





Ser Lys Arg Arg Arg Lys Glu Glu Thr Thr Gly Lys Asn Val Lys Lys 

                245                 250                 255     





Thr Gln His Glu Leu Asp His Asn Gly Leu Val Pro Leu Pro Val Lys 

            260                 265                 270         





Val Cys Phe Thr Cys Asn Arg Ser Cys Arg Val Ala Pro Leu Ile Gln 

        275                 280                 285             





Cys Asp Tyr Cys Pro Leu Leu Phe His Met Asp Cys Leu Glu Pro Pro 

    290                 295                 300                 





Leu Thr Ala Met Pro Leu Gly Arg Trp Met Cys Pro Asn His Ile Glu 

305                 310                 315                 320 





His Val Val Leu Asn Gln Lys Asn Met Thr Leu Ser Asn Arg Cys Gln 

                325                 330                 335     





Val Phe Asp Arg Phe Gln Asp Thr Val Ser Gln His Val Val Lys Val 

            340                 345                 350         





Asp Phe Leu Asn Arg Ile His Lys Lys His Pro Pro Asn Arg Arg Val 

        355                 360                 365             





Leu Gln Ser Val Lys Arg Arg Ser Leu Lys Val Pro Asp Ala Ile Lys 

    370                 375                 380                 





Ser Gln Tyr Gln Phe Pro Pro Pro Leu Ile Ala Pro Ala Ala Ile Arg 

385                 390                 395                 400 





Asp Gly Glu Leu Ile Cys Asn Gly Ile Pro Glu Glu Ser Gln Met His 

                405                 410                 415     





Leu Leu Asn Ser Glu His Leu Ala Thr Gln Ala Glu Gln Gln Glu Trp 

            420                 425                 430         





Leu Cys Ser Val Val Ala Leu Gln Cys Ser Ile Leu Lys His Leu Ser 

        435                 440                 445             





Ala Lys Gln Met Pro Ser His Trp Asp Ser Glu Gln Thr Glu Lys Ala 

    450                 455                 460                 





Asp Ile Lys Pro Val Ile Val Thr Asp Ser Ser Val Thr Thr Ser Leu 

465                 470                 475                 480 





Gln Thr Ala Asp Lys Thr Pro Thr Pro Ser His Tyr Pro Leu Ser Cys 

                485                 490                 495     





Pro Ser Gly Ile Ser Thr Gln Asn Ser Leu Ser Cys Ser Pro Pro His 

            500                 505                 510         





Gln Ser Pro Ala Leu Glu Asp Ile Gly Cys Ser Ser Cys Ala Glu Lys 

        515                 520                 525             





Ser Lys Lys Thr Pro Cys Gly Thr Ala Asn Gly Pro Val Asn Thr Glu 

    530                 535                 540                 





Val Lys Ala Asn Gly Pro His Leu Tyr Ser Ser Pro Thr Asp Ser Thr 

545                 550                 555                 560 





Asp Pro Arg Arg Leu Pro Gly Ala Asn Thr Pro Leu Pro Gly Leu Ser 

                565                 570                 575     





His Arg Gln Gly Trp Pro Arg Pro Leu Thr Pro Pro Ala Ala Gly Gly 

            580                 585                 590         





Leu Gln Asn His Thr Val Gly Ile Ile Val Lys Thr Glu Asn Ala Thr 

        595                 600                 605             





Gly Pro Ser Ser Cys Pro Gln Arg Ser Leu Val Pro Val Pro Ser Leu 

    610                 615                 620                 





Pro Pro Ser Ile Pro Ser Ser Cys Ala Ser Ile Glu Asn Thr Ser Thr 

625                 630                 635                 640 





Leu Gln Arg Lys Thr Val Gln Ser Gln Ile Gly Pro Pro Leu Thr Asp 

                645                 650                 655     





Ser Arg Pro Leu Gly Ser Pro Pro Asn Ala Thr Arg Val Leu Thr Pro 

            660                 665                 670         





Pro Gln Ala Ala Gly Asp Gly Ile Leu Ala Thr Thr Ala Asn Gln Arg 

        675                 680                 685             





Phe Ser Ser Pro Ala Pro Ser Ser Asp Gly Lys Val Ser Pro Gly Thr 

    690                 695                 700                 





Leu Ser Ile Gly Ser Ala Leu Thr Val Pro Ser Phe Pro Ala Asn Ser 

705                 710                 715                 720 





Thr Ala Met Val Asp Leu Thr Asn Ser Leu Arg Ala Phe Met Asp Val 

                725                 730                 735     





Asn Gly Glu Ile Glu Ile Asn Met Leu Asp Glu Lys Leu Ile Lys Phe 

            740                 745                 750         





Leu Ala Leu Gln Arg Ile His Gln Leu Phe Pro Ser Arg Val Gln Pro 

        755                 760                 765             





Ser Pro Gly Ser Val Gly Thr His Gln Leu Ala Ser Gly Gly His His 

    770                 775                 780                 





Ile Glu Val Gln Arg Lys Glu Val Gln Ala Arg Ala Val Phe Tyr Pro 

785                 790                 795                 800 





Leu Leu Gly Leu Gly Gly Ala Val Asn Met Cys Tyr Arg Thr Leu Tyr 

                805                 810                 815     





Ile Gly Thr Gly Ala Asp Met Asp Val Cys Leu Thr Asn Tyr Gly His 

            820                 825                 830         





Cys Asn Tyr Val Ser Gly Lys His Ala Cys Ile Phe Tyr Asp Glu Asn 

        835                 840                 845             





Thr Lys His Tyr Glu Leu Leu Asn Tyr Ser Glu His Gly Thr Thr Val 

    850                 855                 860                 





Asp Asn Val Leu Tyr Ser Cys Asp Phe Ser Glu Lys Thr Pro Pro Thr 

865                 870                 875                 880 





Pro Pro Ser Ser Ile Val Ala Lys Val Gln Ser Val Ile Arg Arg Arg 

                885                 890                 895     





Arg His Gln Lys Gln Asp Glu Glu Pro Ser Glu Glu Ala Ala Met Met 

            900                 905                 910         





Ser Ser Gln Ala Gln Gly Pro Gln Arg Arg Pro Cys Asn Cys Lys Ala 

        915                 920                 925             





Ser Ser Ser Ser Leu Ile Gly Gly Ser Gly Ala Gly Trp Glu Gly Thr 

    930                 935                 940                 





Ala Leu Leu His His Gly Ser Tyr Ile Lys Leu Gly Cys Leu Gln Phe 

945                 950                 955                 960 





Val Phe Ser Ile Thr Glu Phe Ala Thr Lys Gln Pro Lys Gly Asp Ala 

                965                 970                 975     





Ser Leu Leu Gln Asp Gly Val Leu Ala Glu Lys Leu Ser Leu Lys Pro 

            980                 985                 990         





His Gln Gly Pro Val Leu Arg Ser  Asn Ser Val Pro 

        995                 1000                 





<210>  222

<211>  2957

<212>  DNA

<213>  Homo sapiens



<400>  222

cgggtggctt tgcgggcgct cgcggtaagt ttgcgccaag tgcgcggcag ccgggacgca       60



gacggcggcg gcggcgagag gcggagcccg gggaccaccc cccatcaccc tccccccagt      120



cacctcacgt accacaacct cacgtaacct ctcacccccc ctccgatacc cccagccccg      180



ggatggcagc gcccgccagc cttcccggcc ggaccggctg tcgccagtgc cggctttagc      240



ctgtgggact aggccccgcc gaggcctgac ccccggagcc gggacccact gtgcagccag      300



cagccgggcc gggactgagg ggccgctccc ccctcgcggc ccgtcgggag gacgctgtcg      360



tcccggggac tgggggccgg ggggtggggg ggagccaggg cgaggaagtc gggacccgta      420



ttgggaaaaa agcggggccg gggtcaggag cgccccctcc cctcacctcc cccctccccc      480



cggggttggg ggggccggag cagagagcac ccagcccggg aggtggatga atgtgggaga      540



aaatggagac caagacgatc gtgtacgact tggacacatc aggggggctg atggagcaaa      600



tccaagctct gctggctccc cccaagacgg acgaggcaga aaagcgcagt cggaagcctg      660



agaaggagcc ccggagaagc ggcagggcca ccaaccacga cagctgcgat agctgcaagg      720



aaggtggaga tctcctgtgc tgcgaccact gcccggctgc cttccacctc cagtgctgta      780



accctccact gagtgaagaa atgttgcctc ctggagagtg gatgtgtcac cggtgcactg      840



ttcgccgaaa gaaacgagag cagaaaaagg agctgggtca tgtcaatgga ctggtggaca      900



aatctggcaa acggactaca tcccccagca gtgacactga cttgttggac agatcggcca      960



gcaaaactga actaaaggcc attgcccatg cccggatcct ggaaaggaga gccagcaggc     1020



ctggcacacc cacatccagc gccagcacag agactcccac ctctgagcag aatgatgtcg     1080



acgaagacat cattgacgtg gatgaggaac cagtagcagc ggagccagac tatgtgcagc     1140



cccagctgag gcggcccttt gagctgctga ttgctgccgc catggagcgg aaccccaccc     1200



aatttcagtt gcccaatgaa ctgacttgta ccactgcact accaggttct agcaagagga     1260



gaagaaagga ggaaaccaca gggaaaaatg ttaagaagac acagcatgaa ttagatcaca     1320



atggtctcgt tcccttaccc gtcaaagtct gcttcacgtg taacaggagt tgccgtgtgg     1380



ctcctctcat ccagtgtgac tattgccctc tcctgtttca catggattgc ctcgagccgc     1440



cgctcactgc catgcccctg ggcagatgga tgtgtccgaa tcacatcgaa catgtggtgc     1500



tgaaccagaa gaatatgaca ctgagcaatc ggtgccaggt gtttgatcgt ttccaggaca     1560



ccgtttcgca gcatgtcgtc aaagtggact tcctgaaccg aatccacaag aagcaccccc     1620



ctaaccggcg tgtgctccag tcggtcaaaa gaagaagctt gaaggttcct gatgctataa     1680



aatctcagta ccagtttcca ccccctctca ttgcacccgc ggccattcgg gacggggagc     1740



tgatctgcaa tgggatccct gaggaatcac agatgcacct tttgaactct gagcacttag     1800



ccacccaagc agagcagcaa gagtggctct gtagtgttgt tgcgctccag tgcagcatat     1860



tgaaacattt atctgctaag cagatgcctt cgcattggga ctctgaacag acagagaagg     1920



ctgatattaa gcctgttatt gtgactgaca gctcagtcac cacctccctg caaacagctg     1980



acaagacacc tacaccttcc cactacccct tgtcctgccc ctcagggatt agcacccaga     2040



attccctgag ctgctctcca ccccaccagt ccccagccct agaggacatc ggctgcagtt     2100



cttgtgcgga aaaatccaag aaaacccctt gtgggactgc caatgggcca gtgaacacag     2160



aggtgaaagc taatggccca cacctctaca gcagccctac tgattccacg gacccccggc     2220



gacttccagg cgctaacacc ccactaccag gcctctcaca ccggcaaggc tggccccggc     2280



ccctcacgcc accagcggct gggggccttc agaaccacac cgtcggcatc attgtgaaga     2340



cagagaatgc cactggcccc agctcttgcc cccagaggag tttggttcct gtcccaagcc     2400



tgcccccttc cattcccagc tcttgtgcca gcatcgagaa caccagcact ttgcaaagaa     2460



agactgtcca atcacagata ggacctccgt tgacagattc aaggccactg ggctcacccc     2520



caaacgccac ccgggtgctc actcccccgc aagcagcagg agatggtatc ttggccacaa     2580



cagccaacca acgattcagc tcaccagcgc catcgtcagg tgagtgctgc tcagccttgg     2640



gttgatttgg aataatttta tgctctttct ggcaaataag attctaaaag cacttatatc     2700



cctgtgaata cttcagagga ctttggcctt tgtattgttt gtcttactct catttccgta     2760



atagaagagg aagcacatgt taacttgtcc cgtttataaa tgggactgct taggctctga     2820



aagcttcagt gatttcctta aaatgaccta ctgagtcagt ggcaggattg gaaccacagc     2880



ccaggtctcc tgactccatc ccataccttc caggcctagg cctctgcctg ttttgttctg     2940



tcaccttaaa agaaggc                                                    2957





<210>  223

<211>  704

<212>  PRT

<213>  Homo sapiens



<400>  223



Met Trp Glu Lys Met Glu Thr Lys Thr Ile Val Tyr Asp Leu Asp Thr 

1               5                   10                  15      





Ser Gly Gly Leu Met Glu Gln Ile Gln Ala Leu Leu Ala Pro Pro Lys 

            20                  25                  30          





Thr Asp Glu Ala Glu Lys Arg Ser Arg Lys Pro Glu Lys Glu Pro Arg 

        35                  40                  45              





Arg Ser Gly Arg Ala Thr Asn His Asp Ser Cys Asp Ser Cys Lys Glu 

    50                  55                  60                  





Gly Gly Asp Leu Leu Cys Cys Asp His Cys Pro Ala Ala Phe His Leu 

65                  70                  75                  80  





Gln Cys Cys Asn Pro Pro Leu Ser Glu Glu Met Leu Pro Pro Gly Glu 

                85                  90                  95      





Trp Met Cys His Arg Cys Thr Val Arg Arg Lys Lys Arg Glu Gln Lys 

            100                 105                 110         





Lys Glu Leu Gly His Val Asn Gly Leu Val Asp Lys Ser Gly Lys Arg 

        115                 120                 125             





Thr Thr Ser Pro Ser Ser Asp Thr Asp Leu Leu Asp Arg Ser Ala Ser 

    130                 135                 140                 





Lys Thr Glu Leu Lys Ala Ile Ala His Ala Arg Ile Leu Glu Arg Arg 

145                 150                 155                 160 





Ala Ser Arg Pro Gly Thr Pro Thr Ser Ser Ala Ser Thr Glu Thr Pro 

                165                 170                 175     





Thr Ser Glu Gln Asn Asp Val Asp Glu Asp Ile Ile Asp Val Asp Glu 

            180                 185                 190         





Glu Pro Val Ala Ala Glu Pro Asp Tyr Val Gln Pro Gln Leu Arg Arg 

        195                 200                 205             





Pro Phe Glu Leu Leu Ile Ala Ala Ala Met Glu Arg Asn Pro Thr Gln 

    210                 215                 220                 





Phe Gln Leu Pro Asn Glu Leu Thr Cys Thr Thr Ala Leu Pro Gly Ser 

225                 230                 235                 240 





Ser Lys Arg Arg Arg Lys Glu Glu Thr Thr Gly Lys Asn Val Lys Lys 

                245                 250                 255     





Thr Gln His Glu Leu Asp His Asn Gly Leu Val Pro Leu Pro Val Lys 

            260                 265                 270         





Val Cys Phe Thr Cys Asn Arg Ser Cys Arg Val Ala Pro Leu Ile Gln 

        275                 280                 285             





Cys Asp Tyr Cys Pro Leu Leu Phe His Met Asp Cys Leu Glu Pro Pro 

    290                 295                 300                 





Leu Thr Ala Met Pro Leu Gly Arg Trp Met Cys Pro Asn His Ile Glu 

305                 310                 315                 320 





His Val Val Leu Asn Gln Lys Asn Met Thr Leu Ser Asn Arg Cys Gln 

                325                 330                 335     





Val Phe Asp Arg Phe Gln Asp Thr Val Ser Gln His Val Val Lys Val 

            340                 345                 350         





Asp Phe Leu Asn Arg Ile His Lys Lys His Pro Pro Asn Arg Arg Val 

        355                 360                 365             





Leu Gln Ser Val Lys Arg Arg Ser Leu Lys Val Pro Asp Ala Ile Lys 

    370                 375                 380                 





Ser Gln Tyr Gln Phe Pro Pro Pro Leu Ile Ala Pro Ala Ala Ile Arg 

385                 390                 395                 400 





Asp Gly Glu Leu Ile Cys Asn Gly Ile Pro Glu Glu Ser Gln Met His 

                405                 410                 415     





Leu Leu Asn Ser Glu His Leu Ala Thr Gln Ala Glu Gln Gln Glu Trp 

            420                 425                 430         





Leu Cys Ser Val Val Ala Leu Gln Cys Ser Ile Leu Lys His Leu Ser 

        435                 440                 445             





Ala Lys Gln Met Pro Ser His Trp Asp Ser Glu Gln Thr Glu Lys Ala 

    450                 455                 460                 





Asp Ile Lys Pro Val Ile Val Thr Asp Ser Ser Val Thr Thr Ser Leu 

465                 470                 475                 480 





Gln Thr Ala Asp Lys Thr Pro Thr Pro Ser His Tyr Pro Leu Ser Cys 

                485                 490                 495     





Pro Ser Gly Ile Ser Thr Gln Asn Ser Leu Ser Cys Ser Pro Pro His 

            500                 505                 510         





Gln Ser Pro Ala Leu Glu Asp Ile Gly Cys Ser Ser Cys Ala Glu Lys 

        515                 520                 525             





Ser Lys Lys Thr Pro Cys Gly Thr Ala Asn Gly Pro Val Asn Thr Glu 

    530                 535                 540                 





Val Lys Ala Asn Gly Pro His Leu Tyr Ser Ser Pro Thr Asp Ser Thr 

545                 550                 555                 560 





Asp Pro Arg Arg Leu Pro Gly Ala Asn Thr Pro Leu Pro Gly Leu Ser 

                565                 570                 575     





His Arg Gln Gly Trp Pro Arg Pro Leu Thr Pro Pro Ala Ala Gly Gly 

            580                 585                 590         





Leu Gln Asn His Thr Val Gly Ile Ile Val Lys Thr Glu Asn Ala Thr 

        595                 600                 605             





Gly Pro Ser Ser Cys Pro Gln Arg Ser Leu Val Pro Val Pro Ser Leu 

    610                 615                 620                 





Pro Pro Ser Ile Pro Ser Ser Cys Ala Ser Ile Glu Asn Thr Ser Thr 

625                 630                 635                 640 





Leu Gln Arg Lys Thr Val Gln Ser Gln Ile Gly Pro Pro Leu Thr Asp 

                645                 650                 655     





Ser Arg Pro Leu Gly Ser Pro Pro Asn Ala Thr Arg Val Leu Thr Pro 

            660                 665                 670         





Pro Gln Ala Ala Gly Asp Gly Ile Leu Ala Thr Thr Ala Asn Gln Arg 

        675                 680                 685             





Phe Ser Ser Pro Ala Pro Ser Ser Gly Glu Cys Cys Ser Ala Leu Gly 

    690                 695                 700                 





<210>  224

<211>  6947

<212>  DNA

<213>  Homo sapiens



<400>  224

gggctgaaag acacacagaa gtcttcatgg atatagttga tacatttaat catttaattc       60



ctactgaaca cttagatgat gccctatttc taggatccaa cctggagaat gaagtctgtg      120



aggattttag tgcaagtcaa aatgtcttag aggactcgct gaagaacatg ctcagcgata      180



aggatcctat gctaggatct gcaagtaacc agttctgttt gcctgttttg gatagcaatg      240



atcccaattt ccagatgcct tgttcaacag ttgttggtct tgacgatatt atggatgaag      300



gagttgttaa agaaagtggc aatgatacca ttgatgaaga agaactgatt ttacctaaca      360



ggaacttaag ggacaaggta gaagaaaatt cagtgagatc tccaagaaaa tcacctcgtt      420



taatggcaca agaacaagta agaagtttgc gacagagcac tattgccaag cgttcaaatg      480



cagcaccatt aagtaacaca aaaaaagcat ctgggaagac tgtatctact gctaaagcag      540



gagtgaaaca accagaaagg agtcaggtta aagaagaagt atgtatgtca ctgaaacctg      600



agtaccataa ggagaataga aggtgcagcc gaaatagcgg acaaattgaa gtggtacctg      660



aagtatcagt gtcttcaagt cattcttcag tgtcatcttg tcttgaaatg aaggatgaag      720



atggattaga ttctaagcat aagtgtaata atccgggaga aatagatgtg ccatctcatg      780



aattaaattg ttcacttctt tcagagactt gtgttactat tggagaaaag aaaaatgaag      840



ctttgatgga atgtaaagcc aagcctgttg gtagtccatt gtttaagttt tcagataaag      900



aagaacatga acaaaatgat tccatttcag gtaaaacggg tgagactgtt gttgaagaaa      960



tgatagcaac aagaaaagtt gaacaagatt caaaggagac agtaaaatta tcccatgaag     1020



atgaccatat tcttgaggac gctggatctt ctgatatttc tagtgatgct gcttgtacaa     1080



atccaaataa gacagaaaac agccttgtag gtttgcctag ttgtgtagat gaagtgactg     1140



aatgtaattt ggaattgaag gataccatgg gtattgctga taaaactgag aacacccttg     1200



aaagaaataa aattgaaccg ttgggttatt gtgaagatgc ggagtctaat aggcagttgg     1260



agagcactga gtttaataaa tcaaacttag aggtggttga tactagtact tttggaccgg     1320



aaagtaatat cttggaaaat gctatttgtg atgtgcctga ccaaaattca aaacagttga     1380



atgctataga aagtactaaa atagagtccc atgaaacagc aaaccttcag gatgacagaa     1440



acagccagtc aagtagcgtt tcttacttag agtcaaaaag tgtaaaatcc aaacatacaa     1500



aacctgtaat tcattctaag caaaacatga ccacagatgc tccgaagaaa attgttgcag     1560



caaagtatga agtaatacat agcaaaacta aagttaatgt caaaagtgtg aaacgaaata     1620



ctgatgtacc agaatctcag caaaattttc ataggccagt caaagtcaga aaaaaacaaa     1680



ttgataagga gccaaagatt cagagttgca attctggggt taaatctgtg aaaaaccaag     1740



ctcattctgt actgaaaaaa acattacagg atcaaacttt agtacaaatt ttcaagccct     1800



taactcattc tttgagtgat aagtcacacg ctcatcctgg ttgcttgaaa gaacctcatc     1860



atcctgcaca aactggacat gtatcacatt ctagccagaa acagtgtcat aagcctcagc     1920



aacaggcccc agcaatgaaa accaatagtc acgtgaagga agagcttgaa cacccaggcg     1980



ttgagcattt taaggaagag gataaactga aactgaaaaa acctgagaag aacctacaac     2040



cccgccaaag aagaagcagc aaaagttttt ctttagatga gccaccattg ttcattccag     2100



ataacatagc taccataaga agagaaggct ctgatcatag ctcctcattt gaaagcaaat     2160



atatgtggac tcccagcaag cagtgtgggt tttgcaaaaa accacatggc aacaggttta     2220



tggttggctg tgggagatgt gatgactggt ttcatggtga ttgtgttggg ttaagtcttt     2280



ctcaagcaca gcagatgggc gaggaagaca aagaatatgt ctgtgtaaaa tgttgtgctg     2340



aagaagacaa aaagactgaa atactagatc cagatacttt ggaaaaccaa gctacagttg     2400



aattccatag tggagataaa acaatggagt gtgaaaagct tggattatca aaacacacaa     2460



caaatgatag aaccaaatat atagatgata cagtgaagca caaggtcaaa attttaaaac     2520



gggagtctgg tgaaggcaga aattcatcag actgtagaga taatgaaatt aaaaaatggc     2580



agctagctcc tcttcgtaag atgggacaac cagttttacc tcggagatcc tcagaagaaa     2640



aaagtgaaaa aataccgaaa gagtctacaa ctgttacttg cacaggagaa aaagcttcaa     2700



aaccaggtac tcatgagaag caagagatga aaaagaagaa agttgaaaaa ggagtgctta     2760



atgtacatcc tgctgcttct gcttccaagc cttctgcaga tcagatcagg caaagtgtca     2820



gacattctct caaagacatt cttatgaaga gacttacaga ctcaaatttg aaggtaccag     2880



aggaaaaggc agcaaaagtt gccacaaaaa ttgagaaaga gcttttctct ttttttcggg     2940



acacagatgc taaatataag aacaaatata gaagtttgat gtttaatttg aaagatccta     3000



aaaacaatat attatttaaa aaagtactga aaggagaagt aactcctgat catcttatca     3060



gaatgagtcc agaagaacta gcttctaaag agttagctgc ttggagacga agagaaaaca     3120



gacataccat agaaatgatt gagaaagagc agagagaagt ggaacgacgg ccaatcacca     3180



aaataactca taaaggtgaa atagaaattg agagtgatgc cccaatgaaa gaacaggaag     3240



cagccatgga gattcaggaa ccagccgcca ataagtcatt ggagaagcca gaaggatctg     3300



aaaaacaaaa agaggaggtt gactctatgt ctaaagatac cactagtcaa cacagacagc     3360



atctttttga tctcaactgc aaaatctgca taggtcgaat ggcaccacct gtagatgatc     3420



tttctccaaa aaaagtaaaa gttgttgtag gagtagctcg caaacattca gacaatgaag     3480



cagaaagtat agcagatgca ttatcttcaa cctcaaatat tttggcttct gaattctttg     3540



aggaggagaa acaggagtct ccaaagtcaa cgttctctcc tgctccacgt ccagagatgc     3600



ctggaactgt tgaagttgag tctacctttc tggctcgatt gaacttcatc tggaaaggtt     3660



ttatcaacat gccttctgtg gcaaaatttg ttaccaaagc ctatccagta tctggctccc     3720



cagaatacct gacagaggac ctaccagata gtattcaagt aggtggcagg atatcacctc     3780



agacagtttg ggattatgtg gaaaaaataa aagcatcagg aaccaaggaa atttgtgtgg     3840



ttcgcttcac accagtaact gaagaagatc aaatttctta tactttgctc tttgcatact     3900



tcagtagcag aaagcgctat ggagtagctg ctaacaacat gaagcaggtt aaagatatgt     3960



accttattcc tttgggtgcc acagataaaa ttccacaccc tcttgtgcct tttgatggac     4020



ctgggcttga actgcataga cctaatctat tgttgggctt aattattcgt cagaaactga     4080



agcgacagca cagtgcctgt gctagtacta gtcatatagc tgagactcct gaaagtgcac     4140



caccaatagc attgccacct gataaaaaaa gtaaaataga agtttctaca gaagaagcac     4200



cagaggaaga aaatgacttt tttaattctt ttacaactgt attacacaag cagagaaata     4260



aacctcagca gaatcttcag gaagaccttc caacagcagt tgaaccttta atggaagtca     4320



ccaaacagga gccaccaaaa cctttaagat ttcttcctgg cgtgttgatt ggctgggaga     4380



atcaacctac tactctggaa ttagcaaata aacctcttcc tgtggatgat atacttcaaa     4440



gccttttggg caccactggt caagtatatg accaggccca gtcagtgatg gaacaaaaca     4500



ctgttaaaga aattccattt ttaaatgagc agaccaactc aaaaatagag aaaacagata     4560



atgtggaagt aactgatggt gaaaacaagg agataaaagt taaagtagat aatatttcag     4620



aatctacaga taagtcagca gaaatagaaa catcagtagt agggtcctct tccatttctg     4680



cagggtcttt gacgagtctt agtctcagag gtaagccacc agatgtttct acagaagcat     4740



ttttaacaaa tttatcaatt cagtcaaaac aagaggaaac tgtggagagt aaagagaaaa     4800



cattaaaaag acagcttcag gaagatcaag agaataattt gcaagataac cagacttcaa     4860



atagttctcc atgcagatct aatgtaggaa aaggaaacat agatggtaat gtgagctgta     4920



gtgaaaacct tgttgctaat acagcgaggt ctccacagtt tatcaacctg aaaagggatc     4980



ctaggcaagc agcaggacga agtcagcctg taactacttc agaaagcaaa gatggagata     5040



gttgccggaa tggagaaaaa cacatgctgc ctggcctgtc acacaacaag gagcacttaa     5100



cagaacaaat caatgtagag gaaaagttgt gttctgcaga gaaaaactcg tgtgttcagc     5160



agagtgacaa tttaaaagtt gcacaaaact caccatcagt agaaaacata cagacttctc     5220



aagcagaaca agcaaaaccc ttacaggagg atattttaat gcaaaatatt gaaactgtgc     5280



acccatttcg aagaggatca gcagtagcga catctcattt tgaagttgga aacacatgtc     5340



catcagaatt tccttctaaa agcatcacct ttacttccag aagcaccagc cccagaacaa     5400



gtacaaactt ttcacccatg aggccacagc agcccaacct tcagcatctc aagtctagcc     5460



cacctggatt tccatttcca gggcctccta attttccccc acaaagcatg tttggatttc     5520



caccacattt gccacctcca ttacttcccc ctccaggctt tggctttgct caaaatccca     5580



tggttccctg gccacctgtt gttcatctcc caggtcagcc acagcgtatg atgggtcctc     5640



tctcacaagc atcaaggtat ataggcccgc agaattttta ccaggttaaa gacattcgga     5700



ggccagaaag gcgccatagt gacccttggg gtaggcaaga ccaacagcaa ctggataggc     5760



catttaatag gggtaaaggg gaccgccaga gattttatag tgattcacac catttgaaaa     5820



gagagcgaca tgaaaaggaa tgggagcaag aatctgaaag gcatagacgc agagacagaa     5880



gccaagacaa ggacagagac agaaaaagca gggaggaagg gcacaaagat aaagagaggg     5940



cacggttatc acatggtgat cgaggaacag atggaaaagc aagcagagat agtaggaatg     6000



tagacaagaa gccagataaa cctaaaagtg aagactatga gaaggacaaa gaacgagaga     6060



aaagtaaaca cagagaagga gaaaaggaca gggataggta ccacaaagat agggaccaca     6120



ctgacagaac taaaagcaaa aggtaaaatt tgcaggctgc ttcaggatta catttaaata     6180



actgttaaaa tgttgtatct tgtaaacaaa agaaagattg cctgctagga ttgtgccatc     6240



tttaaaattt ttactattgg tcatttgcag aacagtaaat tctgtgtgtt ggtacagagt     6300



gctctgtacc agtgctcatc atcccttctt cataccaacg gtccctagtt ataggaattt     6360



aatattttta aaagttttac attgctgtat attcaaagat ttgttttatt aatatgcaat     6420



aaaggcttag aaattttagt tttattcctt aattggtaaa tatggttaac tatggaatat     6480



atttacttcc tctagtgaat gtcctttata taatgactaa tttgggagta atgtgtgctc     6540



tgtaagtttg ttttaaattg cactgttttt aaagaaactg tagaggagca acaaaaatcc     6600



aagcaacttc ataatcagat tatgctaatc atttagttga gcagtttttg accaagaatc     6660



agaagcccaa ggggtacatt tattgcttta atctgcactc attgaagtca tttattacca     6720



tatactacag ctttgtggta ggccattatt ttcattttca tttttggctc ttcagaaact     6780



tgaatactta agcttgtaca tgatcttgtg ttttgctatc ctttttactg taaaatgtaa     6840



atattttaag ggatattttg attctaaata tgataaaata atttctcacc tattttgtgt     6900



gtgtgacttg aaattcagta gtaaaagaat ttcttcttta aagcttt                   6947





<210>  225

<211>  2039

<212>  PRT

<213>  Homo sapiens



<400>  225



Met Asp Ile Val Asp Thr Phe Asn His Leu Ile Pro Thr Glu His Leu 

1               5                   10                  15      





Asp Asp Ala Leu Phe Leu Gly Ser Asn Leu Glu Asn Glu Val Cys Glu 

            20                  25                  30          





Asp Phe Ser Ala Ser Gln Asn Val Leu Glu Asp Ser Leu Lys Asn Met 

        35                  40                  45              





Leu Ser Asp Lys Asp Pro Met Leu Gly Ser Ala Ser Asn Gln Phe Cys 

    50                  55                  60                  





Leu Pro Val Leu Asp Ser Asn Asp Pro Asn Phe Gln Met Pro Cys Ser 

65                  70                  75                  80  





Thr Val Val Gly Leu Asp Asp Ile Met Asp Glu Gly Val Val Lys Glu 

                85                  90                  95      





Ser Gly Asn Asp Thr Ile Asp Glu Glu Glu Leu Ile Leu Pro Asn Arg 

            100                 105                 110         





Asn Leu Arg Asp Lys Val Glu Glu Asn Ser Val Arg Ser Pro Arg Lys 

        115                 120                 125             





Ser Pro Arg Leu Met Ala Gln Glu Gln Val Arg Ser Leu Arg Gln Ser 

    130                 135                 140                 





Thr Ile Ala Lys Arg Ser Asn Ala Ala Pro Leu Ser Asn Thr Lys Lys 

145                 150                 155                 160 





Ala Ser Gly Lys Thr Val Ser Thr Ala Lys Ala Gly Val Lys Gln Pro 

                165                 170                 175     





Glu Arg Ser Gln Val Lys Glu Glu Val Cys Met Ser Leu Lys Pro Glu 

            180                 185                 190         





Tyr His Lys Glu Asn Arg Arg Cys Ser Arg Asn Ser Gly Gln Ile Glu 

        195                 200                 205             





Val Val Pro Glu Val Ser Val Ser Ser Ser His Ser Ser Val Ser Ser 

    210                 215                 220                 





Cys Leu Glu Met Lys Asp Glu Asp Gly Leu Asp Ser Lys His Lys Cys 

225                 230                 235                 240 





Asn Asn Pro Gly Glu Ile Asp Val Pro Ser His Glu Leu Asn Cys Ser 

                245                 250                 255     





Leu Leu Ser Glu Thr Cys Val Thr Ile Gly Glu Lys Lys Asn Glu Ala 

            260                 265                 270         





Leu Met Glu Cys Lys Ala Lys Pro Val Gly Ser Pro Leu Phe Lys Phe 

        275                 280                 285             





Ser Asp Lys Glu Glu His Glu Gln Asn Asp Ser Ile Ser Gly Lys Thr 

    290                 295                 300                 





Gly Glu Thr Val Val Glu Glu Met Ile Ala Thr Arg Lys Val Glu Gln 

305                 310                 315                 320 





Asp Ser Lys Glu Thr Val Lys Leu Ser His Glu Asp Asp His Ile Leu 

                325                 330                 335     





Glu Asp Ala Gly Ser Ser Asp Ile Ser Ser Asp Ala Ala Cys Thr Asn 

            340                 345                 350         





Pro Asn Lys Thr Glu Asn Ser Leu Val Gly Leu Pro Ser Cys Val Asp 

        355                 360                 365             





Glu Val Thr Glu Cys Asn Leu Glu Leu Lys Asp Thr Met Gly Ile Ala 

    370                 375                 380                 





Asp Lys Thr Glu Asn Thr Leu Glu Arg Asn Lys Ile Glu Pro Leu Gly 

385                 390                 395                 400 





Tyr Cys Glu Asp Ala Glu Ser Asn Arg Gln Leu Glu Ser Thr Glu Phe 

                405                 410                 415     





Asn Lys Ser Asn Leu Glu Val Val Asp Thr Ser Thr Phe Gly Pro Glu 

            420                 425                 430         





Ser Asn Ile Leu Glu Asn Ala Ile Cys Asp Val Pro Asp Gln Asn Ser 

        435                 440                 445             





Lys Gln Leu Asn Ala Ile Glu Ser Thr Lys Ile Glu Ser His Glu Thr 

    450                 455                 460                 





Ala Asn Leu Gln Asp Asp Arg Asn Ser Gln Ser Ser Ser Val Ser Tyr 

465                 470                 475                 480 





Leu Glu Ser Lys Ser Val Lys Ser Lys His Thr Lys Pro Val Ile His 

                485                 490                 495     





Ser Lys Gln Asn Met Thr Thr Asp Ala Pro Lys Lys Ile Val Ala Ala 

            500                 505                 510         





Lys Tyr Glu Val Ile His Ser Lys Thr Lys Val Asn Val Lys Ser Val 

        515                 520                 525             





Lys Arg Asn Thr Asp Val Pro Glu Ser Gln Gln Asn Phe His Arg Pro 

    530                 535                 540                 





Val Lys Val Arg Lys Lys Gln Ile Asp Lys Glu Pro Lys Ile Gln Ser 

545                 550                 555                 560 





Cys Asn Ser Gly Val Lys Ser Val Lys Asn Gln Ala His Ser Val Leu 

                565                 570                 575     





Lys Lys Thr Leu Gln Asp Gln Thr Leu Val Gln Ile Phe Lys Pro Leu 

            580                 585                 590         





Thr His Ser Leu Ser Asp Lys Ser His Ala His Pro Gly Cys Leu Lys 

        595                 600                 605             





Glu Pro His His Pro Ala Gln Thr Gly His Val Ser His Ser Ser Gln 

    610                 615                 620                 





Lys Gln Cys His Lys Pro Gln Gln Gln Ala Pro Ala Met Lys Thr Asn 

625                 630                 635                 640 





Ser His Val Lys Glu Glu Leu Glu His Pro Gly Val Glu His Phe Lys 

                645                 650                 655     





Glu Glu Asp Lys Leu Lys Leu Lys Lys Pro Glu Lys Asn Leu Gln Pro 

            660                 665                 670         





Arg Gln Arg Arg Ser Ser Lys Ser Phe Ser Leu Asp Glu Pro Pro Leu 

        675                 680                 685             





Phe Ile Pro Asp Asn Ile Ala Thr Ile Arg Arg Glu Gly Ser Asp His 

    690                 695                 700                 





Ser Ser Ser Phe Glu Ser Lys Tyr Met Trp Thr Pro Ser Lys Gln Cys 

705                 710                 715                 720 





Gly Phe Cys Lys Lys Pro His Gly Asn Arg Phe Met Val Gly Cys Gly 

                725                 730                 735     





Arg Cys Asp Asp Trp Phe His Gly Asp Cys Val Gly Leu Ser Leu Ser 

            740                 745                 750         





Gln Ala Gln Gln Met Gly Glu Glu Asp Lys Glu Tyr Val Cys Val Lys 

        755                 760                 765             





Cys Cys Ala Glu Glu Asp Lys Lys Thr Glu Ile Leu Asp Pro Asp Thr 

    770                 775                 780                 





Leu Glu Asn Gln Ala Thr Val Glu Phe His Ser Gly Asp Lys Thr Met 

785                 790                 795                 800 





Glu Cys Glu Lys Leu Gly Leu Ser Lys His Thr Thr Asn Asp Arg Thr 

                805                 810                 815     





Lys Tyr Ile Asp Asp Thr Val Lys His Lys Val Lys Ile Leu Lys Arg 

            820                 825                 830         





Glu Ser Gly Glu Gly Arg Asn Ser Ser Asp Cys Arg Asp Asn Glu Ile 

        835                 840                 845             





Lys Lys Trp Gln Leu Ala Pro Leu Arg Lys Met Gly Gln Pro Val Leu 

    850                 855                 860                 





Pro Arg Arg Ser Ser Glu Glu Lys Ser Glu Lys Ile Pro Lys Glu Ser 

865                 870                 875                 880 





Thr Thr Val Thr Cys Thr Gly Glu Lys Ala Ser Lys Pro Gly Thr His 

                885                 890                 895     





Glu Lys Gln Glu Met Lys Lys Lys Lys Val Glu Lys Gly Val Leu Asn 

            900                 905                 910         





Val His Pro Ala Ala Ser Ala Ser Lys Pro Ser Ala Asp Gln Ile Arg 

        915                 920                 925             





Gln Ser Val Arg His Ser Leu Lys Asp Ile Leu Met Lys Arg Leu Thr 

    930                 935                 940                 





Asp Ser Asn Leu Lys Val Pro Glu Glu Lys Ala Ala Lys Val Ala Thr 

945                 950                 955                 960 





Lys Ile Glu Lys Glu Leu Phe Ser Phe Phe Arg Asp Thr Asp Ala Lys 

                965                 970                 975     





Tyr Lys Asn Lys Tyr Arg Ser Leu Met Phe Asn Leu Lys Asp Pro Lys 

            980                 985                 990         





Asn Asn Ile Leu Phe Lys Lys Val  Leu Lys Gly Glu Val  Thr Pro Asp 

        995                 1000                 1005             





His Leu  Ile Arg Met Ser Pro  Glu Glu Leu Ala Ser  Lys Glu Leu 

    1010                 1015                 1020             





Ala Ala  Trp Arg Arg Arg Glu  Asn Arg His Thr Ile  Glu Met Ile 

    1025                 1030                 1035             





Glu Lys  Glu Gln Arg Glu Val  Glu Arg Arg Pro Ile  Thr Lys Ile 

    1040                 1045                 1050             





Thr His  Lys Gly Glu Ile Glu  Ile Glu Ser Asp Ala  Pro Met Lys 

    1055                 1060                 1065             





Glu Gln  Glu Ala Ala Met Glu  Ile Gln Glu Pro Ala  Ala Asn Lys 

    1070                 1075                 1080             





Ser Leu  Glu Lys Pro Glu Gly  Ser Glu Lys Gln Lys  Glu Glu Val 

    1085                 1090                 1095             





Asp Ser  Met Ser Lys Asp Thr  Thr Ser Gln His Arg  Gln His Leu 

    1100                 1105                 1110             





Phe Asp  Leu Asn Cys Lys Ile  Cys Ile Gly Arg Met  Ala Pro Pro 

    1115                 1120                 1125             





Val Asp  Asp Leu Ser Pro Lys  Lys Val Lys Val Val  Val Gly Val 

    1130                 1135                 1140             





Ala Arg  Lys His Ser Asp Asn  Glu Ala Glu Ser Ile  Ala Asp Ala 

    1145                 1150                 1155             





Leu Ser  Ser Thr Ser Asn Ile  Leu Ala Ser Glu Phe  Phe Glu Glu 

    1160                 1165                 1170             





Glu Lys  Gln Glu Ser Pro Lys  Ser Thr Phe Ser Pro  Ala Pro Arg 

    1175                 1180                 1185             





Pro Glu  Met Pro Gly Thr Val  Glu Val Glu Ser Thr  Phe Leu Ala 

    1190                 1195                 1200             





Arg Leu  Asn Phe Ile Trp Lys  Gly Phe Ile Asn Met  Pro Ser Val 

    1205                 1210                 1215             





Ala Lys  Phe Val Thr Lys Ala  Tyr Pro Val Ser Gly  Ser Pro Glu 

    1220                 1225                 1230             





Tyr Leu  Thr Glu Asp Leu Pro  Asp Ser Ile Gln Val  Gly Gly Arg 

    1235                 1240                 1245             





Ile Ser  Pro Gln Thr Val Trp  Asp Tyr Val Glu Lys  Ile Lys Ala 

    1250                 1255                 1260             





Ser Gly  Thr Lys Glu Ile Cys  Val Val Arg Phe Thr  Pro Val Thr 

    1265                 1270                 1275             





Glu Glu  Asp Gln Ile Ser Tyr  Thr Leu Leu Phe Ala  Tyr Phe Ser 

    1280                 1285                 1290             





Ser Arg  Lys Arg Tyr Gly Val  Ala Ala Asn Asn Met  Lys Gln Val 

    1295                 1300                 1305             





Lys Asp  Met Tyr Leu Ile Pro  Leu Gly Ala Thr Asp  Lys Ile Pro 

    1310                 1315                 1320             





His Pro  Leu Val Pro Phe Asp  Gly Pro Gly Leu Glu  Leu His Arg 

    1325                 1330                 1335             





Pro Asn  Leu Leu Leu Gly Leu  Ile Ile Arg Gln Lys  Leu Lys Arg 

    1340                 1345                 1350             





Gln His  Ser Ala Cys Ala Ser  Thr Ser His Ile Ala  Glu Thr Pro 

    1355                 1360                 1365             





Glu Ser  Ala Pro Pro Ile Ala  Leu Pro Pro Asp Lys  Lys Ser Lys 

    1370                 1375                 1380             





Ile Glu  Val Ser Thr Glu Glu  Ala Pro Glu Glu Glu  Asn Asp Phe 

    1385                 1390                 1395             





Phe Asn  Ser Phe Thr Thr Val  Leu His Lys Gln Arg  Asn Lys Pro 

    1400                 1405                 1410             





Gln Gln  Asn Leu Gln Glu Asp  Leu Pro Thr Ala Val  Glu Pro Leu 

    1415                 1420                 1425             





Met Glu  Val Thr Lys Gln Glu  Pro Pro Lys Pro Leu  Arg Phe Leu 

    1430                 1435                 1440             





Pro Gly  Val Leu Ile Gly Trp  Glu Asn Gln Pro Thr  Thr Leu Glu 

    1445                 1450                 1455             





Leu Ala  Asn Lys Pro Leu Pro  Val Asp Asp Ile Leu  Gln Ser Leu 

    1460                 1465                 1470             





Leu Gly  Thr Thr Gly Gln Val  Tyr Asp Gln Ala Gln  Ser Val Met 

    1475                 1480                 1485             





Glu Gln  Asn Thr Val Lys Glu  Ile Pro Phe Leu Asn  Glu Gln Thr 

    1490                 1495                 1500             





Asn Ser  Lys Ile Glu Lys Thr  Asp Asn Val Glu Val  Thr Asp Gly 

    1505                 1510                 1515             





Glu Asn  Lys Glu Ile Lys Val  Lys Val Asp Asn Ile  Ser Glu Ser 

    1520                 1525                 1530             





Thr Asp  Lys Ser Ala Glu Ile  Glu Thr Ser Val Val  Gly Ser Ser 

    1535                 1540                 1545             





Ser Ile  Ser Ala Gly Ser Leu  Thr Ser Leu Ser Leu  Arg Gly Lys 

    1550                 1555                 1560             





Pro Pro  Asp Val Ser Thr Glu  Ala Phe Leu Thr Asn  Leu Ser Ile 

    1565                 1570                 1575             





Gln Ser  Lys Gln Glu Glu Thr  Val Glu Ser Lys Glu  Lys Thr Leu 

    1580                 1585                 1590             





Lys Arg  Gln Leu Gln Glu Asp  Gln Glu Asn Asn Leu  Gln Asp Asn 

    1595                 1600                 1605             





Gln Thr  Ser Asn Ser Ser Pro  Cys Arg Ser Asn Val  Gly Lys Gly 

    1610                 1615                 1620             





Asn Ile  Asp Gly Asn Val Ser  Cys Ser Glu Asn Leu  Val Ala Asn 

    1625                 1630                 1635             





Thr Ala  Arg Ser Pro Gln Phe  Ile Asn Leu Lys Arg  Asp Pro Arg 

    1640                 1645                 1650             





Gln Ala  Ala Gly Arg Ser Gln  Pro Val Thr Thr Ser  Glu Ser Lys 

    1655                 1660                 1665             





Asp Gly  Asp Ser Cys Arg Asn  Gly Glu Lys His Met  Leu Pro Gly 

    1670                 1675                 1680             





Leu Ser  His Asn Lys Glu His  Leu Thr Glu Gln Ile  Asn Val Glu 

    1685                 1690                 1695             





Glu Lys  Leu Cys Ser Ala Glu  Lys Asn Ser Cys Val  Gln Gln Ser 

    1700                 1705                 1710             





Asp Asn  Leu Lys Val Ala Gln  Asn Ser Pro Ser Val  Glu Asn Ile 

    1715                 1720                 1725             





Gln Thr  Ser Gln Ala Glu Gln  Ala Lys Pro Leu Gln  Glu Asp Ile 

    1730                 1735                 1740             





Leu Met  Gln Asn Ile Glu Thr  Val His Pro Phe Arg  Arg Gly Ser 

    1745                 1750                 1755             





Ala Val  Ala Thr Ser His Phe  Glu Val Gly Asn Thr  Cys Pro Ser 

    1760                 1765                 1770             





Glu Phe  Pro Ser Lys Ser Ile  Thr Phe Thr Ser Arg  Ser Thr Ser 

    1775                 1780                 1785             





Pro Arg  Thr Ser Thr Asn Phe  Ser Pro Met Arg Pro  Gln Gln Pro 

    1790                 1795                 1800             





Asn Leu  Gln His Leu Lys Ser  Ser Pro Pro Gly Phe  Pro Phe Pro 

    1805                 1810                 1815             





Gly Pro  Pro Asn Phe Pro Pro  Gln Ser Met Phe Gly  Phe Pro Pro 

    1820                 1825                 1830             





His Leu  Pro Pro Pro Leu Leu  Pro Pro Pro Gly Phe  Gly Phe Ala 

    1835                 1840                 1845             





Gln Asn  Pro Met Val Pro Trp  Pro Pro Val Val His  Leu Pro Gly 

    1850                 1855                 1860             





Gln Pro  Gln Arg Met Met Gly  Pro Leu Ser Gln Ala  Ser Arg Tyr 

    1865                 1870                 1875             





Ile Gly  Pro Gln Asn Phe Tyr  Gln Val Lys Asp Ile  Arg Arg Pro 

    1880                 1885                 1890             





Glu Arg  Arg His Ser Asp Pro  Trp Gly Arg Gln Asp  Gln Gln Gln 

    1895                 1900                 1905             





Leu Asp  Arg Pro Phe Asn Arg  Gly Lys Gly Asp Arg  Gln Arg Phe 

    1910                 1915                 1920             





Tyr Ser  Asp Ser His His Leu  Lys Arg Glu Arg His  Glu Lys Glu 

    1925                 1930                 1935             





Trp Glu  Gln Glu Ser Glu Arg  His Arg Arg Arg Asp  Arg Ser Gln 

    1940                 1945                 1950             





Asp Lys  Asp Arg Asp Arg Lys  Ser Arg Glu Glu Gly  His Lys Asp 

    1955                 1960                 1965             





Lys Glu  Arg Ala Arg Leu Ser  His Gly Asp Arg Gly  Thr Asp Gly 

    1970                 1975                 1980             





Lys Ala  Ser Arg Asp Ser Arg  Asn Val Asp Lys Lys  Pro Asp Lys 

    1985                 1990                 1995             





Pro Lys  Ser Glu Asp Tyr Glu  Lys Asp Lys Glu Arg  Glu Lys Ser 

    2000                 2005                 2010             





Lys His  Arg Glu Gly Glu Lys  Asp Arg Asp Arg Tyr  His Lys Asp 

    2015                 2020                 2025             





Arg Asp  His Thr Asp Arg Thr  Lys Ser Lys Arg 

    2030                 2035                 





<210>  226

<211>  4626

<212>  DNA

<213>  Homo sapiens



<400>  226

actgcctccg ccccttcagg tgcgggaagt ctgaagccgg taaacatggc cgtcaccgac       60



agcctcagcc gggctgcgac tgtcttggca actgtgttgc tcttgtcctt cggcagcgtg      120



gccgctagtc atatcgagga tcaagcagaa caattcttta gaagtggcca tacaaacaac      180



tgggctgttc tggtgtgtac atcccgattc tggtttaatt atcgacatgt tgcaaatacc      240



ctttctgttt atagaagtgt caagaggcta ggtattcctg acagtcacat tgtcctaatg      300



cttgcagatg atatggcctg taatcctaga aatcccaaac cagctacagt gtttagtcac      360



aagaatatgg aactaaatgt gtatggagat gatgtggaag tggattatag aagttatgag      420



gtaactgtgg agaatttttt acgggtatta actgggagga tcccacctag tactcctcgg      480



tcaaaacgtc ttctttctga tgacagaagc aatattctaa tttatatgac agggcatggt      540



ggaaatggtt tcttaaaatt tcaagattct gaagaaatta ccaacataga actcgcggat      600



gcttttgaac aaatgtggca gaaaagacgc tacaatgagc tactgtttat tattgatact      660



tgccaaggag catccatgta tgaacgattt tattctccta acataatggc tctagctagt      720



agtcaagtgg gagaagattc actctcgcat caacctgatc ctgcaattgg agtccatctt      780



atggatagat acacatttta tgtcttggaa tttttggaag aaattaaccc agctagccaa      840



actaatatga atgacctttt tcaggtatgt cccaaaagtc tgtgtgtgtc tactcctgga      900



catcgcactg atctttttca gagggatcct aaaaatgtac tgataactga tttctttgga      960



agtgtacgga aagtggaaat tacaacagag actattaaat tgcaacagga ttcagaaatc     1020



atggaaagca gctataagga agaccagatg gatgagaaac taatggaacc tctgaaatat     1080



gctgaacaac ttcctgtagc tcagataata caccagaaac cgaagctgaa agactggcat     1140



cctcctgggg gctttattct gggattatgg gcacttatta tcatggtttt cttcaaaact     1200



tatggaatta agcatatgaa gttcattttt tagacttgat gatgaatgaa gaatgcatgg     1260



aggactgcaa acttggataa taatttatgt cattatatat ttttaaaaat gtgtttctct     1320



tgtatgaatt ggaaataagt ataaggaaac taaatttgaa tcaactatta attttataac     1380



ttaaagaaaa ataattgtta atgcaactgc ttaatggcac taaatatatt ccagttttgt     1440



attttgtgta ttataaaagc gaatgagaca gagatcagaa tacattgact gtttttgaaa     1500



atagtaattt ccccttatcc ccttttcatt tggaaaagaa acaattgtga agacattaaa     1560



ttctcactaa cagaagtaac tttggttaat tattttttgt atatcctccc aatcttttga     1620



cttatgcaca tattttttcc caatatggag atcatatgga atgtactatt ttgtaatgtc     1680



ttttttcatt ttacaatgta ttatcaacct tttccctctc aaaaatacat tgtgaatgac     1740



tgcatagtat tcactttatg aatatttaat tcatttcaca gtcttctatt gttggaccac     1800



ttacattgta ccaaatgttt tcctttggtt tattctttaa tgtattaata ttttactgct     1860



ggtcactcat ggaatcctgc agctttaatt aaaagcaaag atgaaaaatt ggttttttaa     1920



tctatggcac tgacaatctc caggacctta tatgtttgtt gtcagtttat ttgggaaatt     1980



ttagaccttt gataatttca cgtactgact gctcaagaga aacatacccc attgtttttc     2040



atttgtaagc gttctgtgat cttctacaat tggtcacgtc ctcttcattt tccatcttga     2100



aagagagagc caacaaggac tttatttcat tctgttttag gtaaacctcc ttgcccactg     2160



gctgtatcta tactttcctt gagaaaaatc ccataaagtg gatggacctg tgaagaaaat     2220



gtatgcttat ggcctagcct tcatgtctgg ctgatgtatc ctataaggca gtaagcccct     2280



tttctagtct ctggtaagat gcaagagctc atatccccat cactgacatt ttagtttgga     2340



aataatattg agactgtgct atgaccaacc cctgatgttg ttttttcttt tcaaactttt     2400



gcatatgagt agaggaaaag cctaaaagtt aagtatttat gtctgggggg ataccttcag     2460



gtgtcttatc tgttttatgc aagaatttat gtgttcatct ttattcagtg caaagatttt     2520



tttttaaatt ttgtttataa ttgtaggtaa cattaagaca actcttcctc cacaagaaaa     2580



cctcctaaaa ttaatattcc ttaagatttg tttttccttt tgcacttata atattacctt     2640



ttaattgcat gcaagattgt catacttttc aaaaggcaaa ggattgactg tgttatctcc     2700



ctagttagaa caaatgatat tgaggctttt tgccagctct gaatctttat tttaattgat     2760



ctttttattg atgtgttata taaatgagga agaaaaattt tgtctgatta tgtgaaggat     2820



ctttctgtac atgaaaagaa gggaaaataa acttgcaatt gaatagactg attatagtag     2880



cactgagaca caaaaagatt gaccatgttg ccctccagac actcatacaa ggtcgtggac     2940



accacggtga ggcggagcta tttagggtgg taaaggaatt atgattgttc ttgagccaaa     3000



gtaatttagt ttgaatataa tgaaacatac cctgtaaaga ctgctagaaa gtaaaaggat     3060



tcgtcttcag aggttgtaga aggtgccctt cttagttaaa accaaactgg gaaaagtaat     3120



actggataaa atattcagga taaattttgc ctcagcagaa tttcaaaggg cagttgttcc     3180



tctgtttcat tattgaatct tcagaatata gttaaagcca aaagcttaaa atatgttaaa     3240



tgtttcactt ataaccataa tctttttaca tagagcatac tctgccttca taataactaa     3300



atcctctgca tgtggtagat gagtacgttt aggaaatatt gtcagtgcaa ttaaatggcc     3360



tacactttaa acagtatcat aaaaacaaat ccttaaatat attctacttg agtcacaaaa     3420



gctgaacaac agaaaggtgt tttgtttttg cctttctcac agtgttgtgg tgagaatcag     3480



atgagatagt attttgacta aacacttctg aaattgtaaa tatatggtgg cattattgtt     3540



cttatgtcgg cttaggagga taccaaaggg gaagttaatg gtcacagtgc acttatgtag     3600



ctttctaagc tactcaatgt gattcttgtt ctctttgctg ttctttttct cctcccccat     3660



ggtgtccttc agagagaaaa ggaatgtaga taaatgaatc cctgcagatg tgtcctgaca     3720



tttcagggag ggacagggta taatgatgcc atcctgcaaa ggcagcctgt gtgagaaaaa     3780



gaaatcaaat aatgtggatt ttaaaattac gaaagacatt catttgcagt ttatgaaagg     3840



aaaatgtagt ttggatacaa agctgattaa attggatcaa gaaatattag aattaaatgc     3900



aaaaaataat ccatgcattt atggttttga tttttatata ttcccagcta gttgaaaatg     3960



atgattccca caagaagcat aactcagctt gtttctgctt actgagtatt ttctactatg     4020



gtatatattg ataacatttc ttccattatg tatgttgtat accagagtta cagttactgt     4080



gggaatcata atttgaaatt ttgactcctg tgtttctgga atctttacaa caaatgttgc     4140



attaacatat aacttttttc agttgacttt accaaaatta agcccatctt tagtagatac     4200



tgttttaaca tgtgaaagaa atacgttata aacataccac aagatatggc tataaaacaa     4260



tgagatcagt atccattttt gctttaaaga attggcctta ttgcttcagt gtcacatctc     4320



atactcaagg gcatttacta caaagaaaga gttctccaat attgctgttc tgttgctgcc     4380



tgccctattt acacatgtac ctgctactta aataggaaag cctttcaatt catggacaat     4440



acaccttggt ggtaaccagg cttttatttt tatttttttt tcttagtgta aaaactgtac     4500



tgttttggaa atgtgctgtg aaatattagg tttaactgtg tagatcctag aataagggga     4560



tttatataga tgaagttgta accaagaaac tggttattaa aaatttattt actccaaaca     4620



tggaaa                                                                4626





<210>  227

<211>  395

<212>  PRT

<213>  Homo sapiens



<400>  227



Met Ala Val Thr Asp Ser Leu Ser Arg Ala Ala Thr Val Leu Ala Thr 

1               5                   10                  15      





Val Leu Leu Leu Ser Phe Gly Ser Val Ala Ala Ser His Ile Glu Asp 

            20                  25                  30          





Gln Ala Glu Gln Phe Phe Arg Ser Gly His Thr Asn Asn Trp Ala Val 

        35                  40                  45              





Leu Val Cys Thr Ser Arg Phe Trp Phe Asn Tyr Arg His Val Ala Asn 

    50                  55                  60                  





Thr Leu Ser Val Tyr Arg Ser Val Lys Arg Leu Gly Ile Pro Asp Ser 

65                  70                  75                  80  





His Ile Val Leu Met Leu Ala Asp Asp Met Ala Cys Asn Pro Arg Asn 

                85                  90                  95      





Pro Lys Pro Ala Thr Val Phe Ser His Lys Asn Met Glu Leu Asn Val 

            100                 105                 110         





Tyr Gly Asp Asp Val Glu Val Asp Tyr Arg Ser Tyr Glu Val Thr Val 

        115                 120                 125             





Glu Asn Phe Leu Arg Val Leu Thr Gly Arg Ile Pro Pro Ser Thr Pro 

    130                 135                 140                 





Arg Ser Lys Arg Leu Leu Ser Asp Asp Arg Ser Asn Ile Leu Ile Tyr 

145                 150                 155                 160 





Met Thr Gly His Gly Gly Asn Gly Phe Leu Lys Phe Gln Asp Ser Glu 

                165                 170                 175     





Glu Ile Thr Asn Ile Glu Leu Ala Asp Ala Phe Glu Gln Met Trp Gln 

            180                 185                 190         





Lys Arg Arg Tyr Asn Glu Leu Leu Phe Ile Ile Asp Thr Cys Gln Gly 

        195                 200                 205             





Ala Ser Met Tyr Glu Arg Phe Tyr Ser Pro Asn Ile Met Ala Leu Ala 

    210                 215                 220                 





Ser Ser Gln Val Gly Glu Asp Ser Leu Ser His Gln Pro Asp Pro Ala 

225                 230                 235                 240 





Ile Gly Val His Leu Met Asp Arg Tyr Thr Phe Tyr Val Leu Glu Phe 

                245                 250                 255     





Leu Glu Glu Ile Asn Pro Ala Ser Gln Thr Asn Met Asn Asp Leu Phe 

            260                 265                 270         





Gln Val Cys Pro Lys Ser Leu Cys Val Ser Thr Pro Gly His Arg Thr 

        275                 280                 285             





Asp Leu Phe Gln Arg Asp Pro Lys Asn Val Leu Ile Thr Asp Phe Phe 

    290                 295                 300                 





Gly Ser Val Arg Lys Val Glu Ile Thr Thr Glu Thr Ile Lys Leu Gln 

305                 310                 315                 320 





Gln Asp Ser Glu Ile Met Glu Ser Ser Tyr Lys Glu Asp Gln Met Asp 

                325                 330                 335     





Glu Lys Leu Met Glu Pro Leu Lys Tyr Ala Glu Gln Leu Pro Val Ala 

            340                 345                 350         





Gln Ile Ile His Gln Lys Pro Lys Leu Lys Asp Trp His Pro Pro Gly 

        355                 360                 365             





Gly Phe Ile Leu Gly Leu Trp Ala Leu Ile Ile Met Val Phe Phe Lys 

    370                 375                 380                 





Thr Tyr Gly Ile Lys His Met Lys Phe Ile Phe 

385                 390                 395 





<210>  228

<211>  1353

<212>  DNA

<213>  Homo sapiens



<400>  228

accagggggc ggggcctgcc cggctggcct ggacgaacgg gaagccggga gctcggccac       60



gggtggcgag gctgcggtga ggcctggtct ccggctgcca gaccatgctg agtggagcac      120



gctgcaggct cgcctcagcg ctgcggggaa cgcgcgcgcc gccgtccgcg gtcgcccgta      180



ggtgcctgca cgcgtcgggg tcgcggcctt tggccgaccg gggcaagaag actgaggagc      240



cgccccgcga cttcgatccg gcgctgctgg agttcctggt gtgcccgctc tccaagaagc      300



cgctcagata tgaagcatca acaaacgaat tgattaatga agagttggga atagcttatc      360



caatcattga tgggatccct aatatgatac cacaggcagc taggatgaca cgtcaaagta      420



agaagcaaga agaagtggag cagcgctagt tcataattta aaaaaattaa aaaaacgcaa      480



cagccaactt ttcttaatac catatacctt ttaaaacaca gtggcaggta ataagtggaa      540



gagaagaatg tttctgtctc ttcctacgtt gactgttctt attccactgg tttctttagc      600



aggactgttc tactcagcct ctgtggaaga aaacttccca cagggctgca ctagcacagc      660



cagcctttgc ttttacagcc tgctcttgcc tattaccata ccagtgtatg tattcttcca      720



cctttggact tggatgggta ttaaactctt caggcataat tgatgcaact agagtcaata      780



tgctgtatat attaatgata gctcttgggc atcgatctct gaaagctcaa atggatggaa      840



tttagtttgc gggaaagagg ctttgctttg cgcatatcag gcttaggact gtgggaggct      900



taagttgcag atgcttcttt tattgtactc ttgttctgcc cttgtttttt gaaggctctg      960



acttataact gctgtatcag aagaaacatt ttgacagtgt cttggttgga gatgaacatc     1020



cctaattgac atgtgatgac tatttcttat tccattcatc taagagtcat tgaaattttg     1080



ttttgcttgt ttgtttagct tcaaggtctt tggtaaagtc acatgttaag gatgactgaa     1140



ataattccaa aggagtgatg ttggaatagt ccctctaagg gagagaaatg catttgaacg     1200



aatgtgatat aaaaccacat aatcaaatag aaacttcatg tacttacaaa aactgagttt     1260



gtaaaattac cttcatttct ttgacattaa atgcttatat tagcaataaa catgttgaca     1320



ctttcctata aaaaataaac cagtttgcag tag                                  1353





<210>  229

<211>  71

<212>  PRT

<213>  Homo sapiens



<400>  229



Met Phe Leu Ser Leu Pro Thr Leu Thr Val Leu Ile Pro Leu Val Ser 

1               5                   10                  15      





Leu Ala Gly Leu Phe Tyr Ser Ala Ser Val Glu Glu Asn Phe Pro Gln 

            20                  25                  30          





Gly Cys Thr Ser Thr Ala Ser Leu Cys Phe Tyr Ser Leu Leu Leu Pro 

        35                  40                  45              





Ile Thr Ile Pro Val Tyr Val Phe Phe His Leu Trp Thr Trp Met Gly 

    50                  55                  60                  





Ile Lys Leu Phe Arg His Asn 

65                  70      





<210>  230

<211>  1353

<212>  DNA

<213>  Homo sapiens



<400>  230

accagggggc ggggcctgcc cggctggcct ggacgaacgg gaagccggga gctcggccac       60



gggtggcgag gctgcggtga ggcctggtct ccggctgcca gaccatgctg agtggagcac      120



gctgcaggct cgcctcagcg ctgcggggaa cgcgcgcgcc gccgtccgcg gtcgcccgta      180



ggtgcctgca cgcgtcgggg tcgcggcctt tggccgaccg gggcaagaag actgaggagc      240



cgccccgcga cttcgatccg gcgctgctgg agttcctggt gtgcccgctc tccaagaagc      300



cgctcagata tgaagcatca acaaacgaat tgattaatga agagttggga atagcttatc      360



caatcattga tgggatccct aatatgatac cacaggcagc taggatgaca cgtcaaagta      420



agaagcaaga agaagtggag cagcgctagt tcataattta aaaaaattaa aaaaacgcaa      480



cagccaactt ttcttaatac catatacctt ttaaaacaca gtggcaggta ataagtggaa      540



gagaagaatg tttctgtctc ttcctacgtt gactgttctt attccactgg tttctttagc      600



aggactgttc tactcagcct ctgtggaaga aaacttccca cagggctgca ctagcacagc      660



cagcctttgc ttttacagcc tgctcttgcc tattaccata ccagtgtatg tattcttcca      720



cctttggact tggatgggta ttaaactctt caggcataat tgatgcaact agagtcaata      780



tgctgtatat attaatgata gctcttgggc atcgatctct gaaagctcaa atggatggaa      840



tttagtttgc gggaaagagg ctttgctttg cgcatatcag gcttaggact gtgggaggct      900



taagttgcag atgcttcttt tattgtactc ttgttctgcc cttgtttttt gaaggctctg      960



acttataact gctgtatcag aagaaacatt ttgacagtgt cttggttgga gatgaacatc     1020



cctaattgac atgtgatgac tatttcttat tccattcatc taagagtcat tgaaattttg     1080



ttttgcttgt ttgtttagct tcaaggtctt tggtaaagtc acatgttaag gatgactgaa     1140



ataattccaa aggagtgatg ttggaatagt ccctctaagg gagagaaatg catttgaacg     1200



aatgtgatat aaaaccacat aatcaaatag aaacttcatg tacttacaaa aactgagttt     1260



gtaaaattac cttcatttct ttgacattaa atgcttatat tagcaataaa catgttgaca     1320



ctttcctata aaaaataaac cagtttgcag tag                                  1353





<210>  231

<211>  114

<212>  PRT

<213>  Homo sapiens



<400>  231



Met Leu Ser Gly Ala Arg Cys Arg Leu Ala Ser Ala Leu Arg Gly Thr 

1               5                   10                  15      





Arg Ala Pro Pro Ser Ala Val Ala Arg Arg Cys Leu His Ala Ser Gly 

            20                  25                  30          





Ser Arg Pro Leu Ala Asp Arg Gly Lys Lys Thr Glu Glu Pro Pro Arg 

        35                  40                  45              





Asp Phe Asp Pro Ala Leu Leu Glu Phe Leu Val Cys Pro Leu Ser Lys 

    50                  55                  60                  





Lys Pro Leu Arg Tyr Glu Ala Ser Thr Asn Glu Leu Ile Asn Glu Glu 

65                  70                  75                  80  





Leu Gly Ile Ala Tyr Pro Ile Ile Asp Gly Ile Pro Asn Met Ile Pro 

                85                  90                  95      





Gln Ala Ala Arg Met Thr Arg Gln Ser Lys Lys Gln Glu Glu Val Glu 

            100                 105                 110         





Gln Arg 

        





<210>  232

<211>  5047

<212>  DNA

<213>  Homo sapiens



<400>  232

gcggcggtcg cagctcgggt ccccctcggg cgcccccgcc gccgtccgcg cgcggccatg       60



gagctggagg taccggacga ggcggagagc gctgaggcgg gggccgtgcc ctcggaggcg      120



gcgtgggcgg cagagagcgg ggcggcggca ggtttggctc agaagaaggc ggccccaaca      180



gaggttctgt ccatgacggc acagccgggc cctggccatg ggaagaagtt gggccatcga      240



ggtgtggacg catccggcga aaccacctac aagaagacca cctcctccac cctgaagggt      300



gccatccagc tgggcatcgg ctacaccgtg ggccacctga gctccaagcc cgaacgcgac      360



gtgctcatgc aggacttcta cgtggtggag agcatcttct tccccagcga aggcagcaac      420



ctcacccccg cccaccactt ccaggacttc cgcttcaaga cctatgcacc tgtcgccttc      480



cgctacttcc gggagctctt tgggatccgg ccagatgatt acttgtactc cctgtgcaat      540



gagccgctga tcgagctgtc caacccgggc gccagtggct ccctcttcta cgtcaccagc      600



gacgacgagt tcatcatcaa gaccgtcatg cacaaggagg ccgagttcct gcagaagctg      660



ctccctggct actacatgaa cctcaaccag aacccgcgga cgctgctgcc caagttctat      720



gggctgtact gcgtgcagtc ggggggcaag aacatccgcg tcgtggtcat gaacaacatc      780



ctgccccgcg tggtcaagat gcacctcaag ttcgacctca agggctccac ctacaagcgg      840



cgcgccagca agaaggagaa ggagaagagc ttccccacct acaaggacct ggacttcatg      900



caggacatgc ccgaggggct cctgctggac gccgacacct tcagcgccct ggtcaagacg      960



ctgcagcggg actgcctggt cctggaaagt ttcaagatca tggactacag cctgctgctg     1020



ggcgtgcaca acatcgacca gcacgagcgc gagcggcagg cgcagggcgc ccagagcacc     1080



tcagatgaga agcggcctgt gggccagaag gcgctctact ccacggccat ggagtccatc     1140



cagggtggcg ccgcgcgcgg ggaggccatc gaatcggatg acacgatggg cgggatcccc     1200



gctgtgaacg gccgcgggga gcggctgctg ctgcacattg gcatcatcga catcctgcag     1260



tcctacaggt tcatcaagaa actggagcac acctggaagg ccctcgtcca cgatggggac     1320



acggtgtccg tccaccgccc cagcttctat gccgagcgct ttttcaagtt catgagcaac     1380



acggtctttc ggaagaactc ctccctgaag tcctcgccct ccaagaaggg gcgcggcgga     1440



gccttgctag ctgtgaaacc gctggggccc accgctgcct tctcggccag ccagatccct     1500



agcgagcggg aggaggccca gtacgacctg cggggggccc gcagctaccc cacgctggag     1560



gacgaaggcc ggcccgacct cctgccctgc acgccacctt ctttcgaaga agccactaca     1620



gcctccattg ccacgactct gtcatccaca tccctctcca ttcctgagcg gtccccctcg     1680



gagacgtcgg agcagccgcg gtacaggcgg cgcacacagt cgtctggaca ggatggcagg     1740



ccgcaggagg agccacccgc ggaagaggat ctgcagcaga ttacagtgca ggtggagcct     1800



gcgtgcagcg tggagattgt ggtccccaaa gaggaggacg caggggtgga ggcttccccg     1860



gccggtgcct ctgctgctgt tgaagtagaa actgccagcc aggcctcaga cgaggagggc     1920



gcacctgcca gccaggcctc ggacgaggag gacgcgcccg ccaccgacat ctactttccc     1980



accgatgaga ggagctgggt gtactccccg ctccactata gcgcccaggc ccccccggcc     2040



tccgacggcg agagcgacac ataatttcta tgcagccccc gacccagagc cgagctccac     2100



ttctgctccg gctgcccccg aaggcgctgc ccaccccgct gaggcccaga gctcgggaga     2160



tgcccgcctc gccgccccac cggacctcgt cctccccctg cacggatgcc gacggccggg     2220



cccctccccg acaagcctcc cagggccccg gcaccccggt cggcagcctg cccctgtgag     2280



acccaccctc ccgagcggcc aatcgcattt gagtccttat ttggcacaga gacggaagca     2340



cgtgtgtgcc gttttaggaa aagaacaaaa aagacacaaa caaaccaacc agagggagaa     2400



gagcccctgc ccactgcact ctttggttct ctgctgtgcc tgcctgtgtc ctgaggaaga     2460



agccaggctg ttcgcggtgg cctctgggga cctgagcccc gggggcccca tcggcctgca     2520



gaggggacgg ctggggtccc gagcaactct gcctccatcc acgtgggaag cggaccctcc     2580



tgccctcagc ttgggtttgg gggcctcagt gcaggacatc tggcctgaac atcgactgtg     2640



gggacagccc tcgccctgcc aagcactgcg gccactcagc agctatgttc ccgccgcagt     2700



ggggccctga cgcccacctc ccaggtgccc ctcgagcaaa aacctctggc gcctccaatc     2760



cagacccacc acagctggag ggccaggcct cctcttcccc aggctgccac ccacgctggc     2820



ggagctcagg gctggggact tgtccttctc ttccaacgta ggccactcag caactggcat     2880



ggagggccca ggcaacggag acgttttctc catggcagga cagagcggga ggccgggcct     2940



tgggccacag gagaccagct cagggcggaa ggtcaggctc cccgccccct ccacgtggag     3000



acatggccta gggggccagg cccggctcca caggagtctc cttcaggact ggtgtggatg     3060



tccgccgcct ctttcttgtt taagtgatgt gatgtctccg aggaggggag agaagacttt     3120



gtttccgact catcaccctc caagagggca gcgctcccag tggtgggact cagcccagac     3180



tgccctgggg cagcttcctg ggcccgctgc gctcagaggg tgctggttgg aggccagagc     3240



tcggcagagt cacccaccct gcccttcccc aggacccctg agaggggctt attggtgatg     3300



gctgtgggaa tcccccactt ccaagatgtg cccaggatgt gaggagctgg agtggaagct     3360



gcacctttgg gaagaattcc tctccagacc tggcagagcc tggtgtgggg tctgagacgg     3420



ccggagaacc tcccaggcag ggctctgtgt tttgtctgtt acaacctccg tatgacgcca     3480



cgccacccgc tgttcacgtc ccgtcggcct cctgcacagc ccacacgctg cgcccggaag     3540



gcccctgctg tggagaagcc ggacccatcc ccgaggtccc cagcgaggac acacactcca     3600



cgagagcagc ccctccactc tgcccaggag aggggccgac cctcctcggg aaccggccag     3660



ccgcgtggct cccagcatcc atcaggacaa gcccacgtgg ggtcctccct gcgtgctcag     3720



agggtctgtc cagccctggg aagcgacctt ggcctcagtt cacagcctgg tgctcatctg     3780



ctggcaccgg gcatccaccc atcagccccc gccctgtccc tccgaaggac acccagcagg     3840



caccccccgg ggaggcaggg gcagaggtca gaaggggtgt ctgggacctg gatggccagc     3900



agggacaggg gcattgtcat ctcaaaggcc caacccccag aggccacacc agtcctccca     3960



gggagtcctc gagtcgccct gcccagagcc ctggcaccag agacgccaag agcctgtggg     4020



gtgactcgga gcagcaggtg tggccccggg cgggcggcac cgcgtccagg gcagcctccc     4080



tccgctgagt gacacgggac accagtgccc ggccgacgcg cctttgcagg agaaatgtgc     4140



aaacctctgt ggataccatt tcatttccat tcttgtgttg tctccaaggc ccttttggag     4200



atatacttgg tgttggttgt gttttttggt tccttttcag agaactgtaa accgaggctg     4260



acgtgctcca ctgactgtgc cgaggggcgg gggcaggagg acggcaagac ctatttataa     4320



tatttagcga actcggtctc cctcagatcc cccgcgaggg aggctgctgg acccaccccg     4380



ctgtccccca tgatagaagt ctgtaaatac cttggtgacc aatgcccact tcccctcctg     4440



ggtcacctct gatggctgct gtccactgag aacgtgggca gtgtccaaat tcctgtactg     4500



taaagactaa aaggcgtttg ctctgagact gacaaggcgg aaacttccat gtgtctcctg     4560



ccaggctctg tccccctacg ccatcccgac acgtccccgt tcccccgaaa cctggctcag     4620



tgcaatactc ccattgccat ggggtccttc accatggtac tgtctccaca gccctcagtc     4680



cccaccccag gagaggcgcc tgccacctcc tcctcatctc cggtggttca atcgctccgc     4740



ctgtccccaa cccagtccca tttttatggc caaactgatt ctgaaacaaa atgaaactgc     4800



aaacctcgtg tgtcttaact ccccccaggg atgccactcc attcctccgc cccgtggtct     4860



ggtgcgtgac aatccaaagc gccgagacga gggtgctgtg tccctcaaac ccagagtggt     4920



gggcgcctct gaaaccatac agccactcct ggccccaaac actggtttgc atcccaggtt     4980



cctcgcccac ctacccccgc cacaccccgt ctttttagag atctctctaa taaatcgggt     5040



aataagc                                                               5047





<210>  233

<211>  668

<212>  PRT

<213>  Homo sapiens



<400>  233



Met Glu Leu Glu Val Pro Asp Glu Ala Glu Ser Ala Glu Ala Gly Ala 

1               5                   10                  15      





Val Pro Ser Glu Ala Ala Trp Ala Ala Glu Ser Gly Ala Ala Ala Gly 

            20                  25                  30          





Leu Ala Gln Lys Lys Ala Ala Pro Thr Glu Val Leu Ser Met Thr Ala 

        35                  40                  45              





Gln Pro Gly Pro Gly His Gly Lys Lys Leu Gly His Arg Gly Val Asp 

    50                  55                  60                  





Ala Ser Gly Glu Thr Thr Tyr Lys Lys Thr Thr Ser Ser Thr Leu Lys 

65                  70                  75                  80  





Gly Ala Ile Gln Leu Gly Ile Gly Tyr Thr Val Gly His Leu Ser Ser 

                85                  90                  95      





Lys Pro Glu Arg Asp Val Leu Met Gln Asp Phe Tyr Val Val Glu Ser 

            100                 105                 110         





Ile Phe Phe Pro Ser Glu Gly Ser Asn Leu Thr Pro Ala His His Phe 

        115                 120                 125             





Gln Asp Phe Arg Phe Lys Thr Tyr Ala Pro Val Ala Phe Arg Tyr Phe 

    130                 135                 140                 





Arg Glu Leu Phe Gly Ile Arg Pro Asp Asp Tyr Leu Tyr Ser Leu Cys 

145                 150                 155                 160 





Asn Glu Pro Leu Ile Glu Leu Ser Asn Pro Gly Ala Ser Gly Ser Leu 

                165                 170                 175     





Phe Tyr Val Thr Ser Asp Asp Glu Phe Ile Ile Lys Thr Val Met His 

            180                 185                 190         





Lys Glu Ala Glu Phe Leu Gln Lys Leu Leu Pro Gly Tyr Tyr Met Asn 

        195                 200                 205             





Leu Asn Gln Asn Pro Arg Thr Leu Leu Pro Lys Phe Tyr Gly Leu Tyr 

    210                 215                 220                 





Cys Val Gln Ser Gly Gly Lys Asn Ile Arg Val Val Val Met Asn Asn 

225                 230                 235                 240 





Ile Leu Pro Arg Val Val Lys Met His Leu Lys Phe Asp Leu Lys Gly 

                245                 250                 255     





Ser Thr Tyr Lys Arg Arg Ala Ser Lys Lys Glu Lys Glu Lys Ser Phe 

            260                 265                 270         





Pro Thr Tyr Lys Asp Leu Asp Phe Met Gln Asp Met Pro Glu Gly Leu 

        275                 280                 285             





Leu Leu Asp Ala Asp Thr Phe Ser Ala Leu Val Lys Thr Leu Gln Arg 

    290                 295                 300                 





Asp Cys Leu Val Leu Glu Ser Phe Lys Ile Met Asp Tyr Ser Leu Leu 

305                 310                 315                 320 





Leu Gly Val His Asn Ile Asp Gln His Glu Arg Glu Arg Gln Ala Gln 

                325                 330                 335     





Gly Ala Gln Ser Thr Ser Asp Glu Lys Arg Pro Val Gly Gln Lys Ala 

            340                 345                 350         





Leu Tyr Ser Thr Ala Met Glu Ser Ile Gln Gly Gly Ala Ala Arg Gly 

        355                 360                 365             





Glu Ala Ile Glu Ser Asp Asp Thr Met Gly Gly Ile Pro Ala Val Asn 

    370                 375                 380                 





Gly Arg Gly Glu Arg Leu Leu Leu His Ile Gly Ile Ile Asp Ile Leu 

385                 390                 395                 400 





Gln Ser Tyr Arg Phe Ile Lys Lys Leu Glu His Thr Trp Lys Ala Leu 

                405                 410                 415     





Val His Asp Gly Asp Thr Val Ser Val His Arg Pro Ser Phe Tyr Ala 

            420                 425                 430         





Glu Arg Phe Phe Lys Phe Met Ser Asn Thr Val Phe Arg Lys Asn Ser 

        435                 440                 445             





Ser Leu Lys Ser Ser Pro Ser Lys Lys Gly Arg Gly Gly Ala Leu Leu 

    450                 455                 460                 





Ala Val Lys Pro Leu Gly Pro Thr Ala Ala Phe Ser Ala Ser Gln Ile 

465                 470                 475                 480 





Pro Ser Glu Arg Glu Glu Ala Gln Tyr Asp Leu Arg Gly Ala Arg Ser 

                485                 490                 495     





Tyr Pro Thr Leu Glu Asp Glu Gly Arg Pro Asp Leu Leu Pro Cys Thr 

            500                 505                 510         





Pro Pro Ser Phe Glu Glu Ala Thr Thr Ala Ser Ile Ala Thr Thr Leu 

        515                 520                 525             





Ser Ser Thr Ser Leu Ser Ile Pro Glu Arg Ser Pro Ser Glu Thr Ser 

    530                 535                 540                 





Glu Gln Pro Arg Tyr Arg Arg Arg Thr Gln Ser Ser Gly Gln Asp Gly 

545                 550                 555                 560 





Arg Pro Gln Glu Glu Pro Pro Ala Glu Glu Asp Leu Gln Gln Ile Thr 

                565                 570                 575     





Val Gln Val Glu Pro Ala Cys Ser Val Glu Ile Val Val Pro Lys Glu 

            580                 585                 590         





Glu Asp Ala Gly Val Glu Ala Ser Pro Ala Gly Ala Ser Ala Ala Val 

        595                 600                 605             





Glu Val Glu Thr Ala Ser Gln Ala Ser Asp Glu Glu Gly Ala Pro Ala 

    610                 615                 620                 





Ser Gln Ala Ser Asp Glu Glu Asp Ala Pro Ala Thr Asp Ile Tyr Phe 

625                 630                 635                 640 





Pro Thr Asp Glu Arg Ser Trp Val Tyr Ser Pro Leu His Tyr Ser Ala 

                645                 650                 655     





Gln Ala Pro Pro Ala Ser Asp Gly Glu Ser Asp Thr 

            660                 665             





<210>  234

<211>  3427

<212>  DNA

<213>  Homo sapiens



<400>  234

atgagtgcag tgggcttggt actcctggtg cttgctctga ggcttagggc caccactgtt       60



aagccagagg aaggcagctt ttgctctaac agccaggtgg ccttcagaga tgcttgctat      120



gaatttgtgc cactcggacg caccttccgt gatgcccaga gctggtgcga ggggcaagga      180



ggccatttgg tcttcattca ggacgaaggc acccagtggt ttctgcagaa gcacatctcc      240



caggacaggg aatggtggat tggactcacg tggaacttgg cacggaatgg aaccacggag      300



gggccgggga cttggttgga cacctccaat gtgacctaca gcaactggca tggagggcag      360



gccgccgctg cccctgacac ctgcggccac atcgggagag gcccttcctc tgagtgggtg      420



acctcggact gcgcccagac cttcgccttc atgtgcgagt tccgggttgg ccagagcctg      480



gcctgcgagg gactcaatgc caccgtgcac tgtggcttgg ggcaggtcat ccaggtccag      540



gatgccgtct acgggcgcca gaatccccat ttctgcaccc aggatgccgg gcgtccttca      600



gatctggagc agggatgcag ctgggccaac gtcaaggagg aggtggcagg ccagtgccag      660



gagctacagt catgccaggt ggcagcagat gagacctact ttggaaacct gtgtccgact      720



cagggcagtt acctgtgggt gcagtaccag tgccgggaag ccctgcagct gatggtgtcc      780



agtgagagtt tcatctttga caatgtcacc atctccctga cgtggctcct ctcaccctac      840



ataggaaacc tgtcctgtat aattagtaca ggagacagcc acacttttga tccctacaac      900



ccgccgagtg tgtccagcaa tgtgacccac cagttcacat ctcctgggga attcaccgtg      960



tttgctgaat gcacaaccag tgagtggcat gtgacagctc agaggcaggt gaccgtgcga     1020



gacaagatgg agacgctcag tgtgactgca tgctccggcc tgtcccagtc aggagccggc     1080



cctctctgcc aggctgtctt tggggatcct ctgtggattc aggtggagct tgatggagga     1140



acaggagtga cttacactgt gcttttgggt gacataaccc tggccgagtc caccacccaa     1200



aagggctcgc taccgtacaa tctgatcctg gacagagaaa cccagaaact gatgggccct     1260



gggaggcacc gcctggagat ccaagccacc ggcaacacca ccacctctac aatctccaga     1320



aacattacag tccacttggt ggagctgctg tcagggctgc aggcctcctg ggcttctgac     1380



catttggagc ttggacagga cctattgatc accatctcat tggctcaggg caccccggaa     1440



gagctgacct ttgaggtggc tggactcaat gcaaccttct cccacgagca agtgagcttt     1500



ggagagccat ttgggatttg ccgcctggct gttccggttg aaggcacctt tctggtcacc     1560



atgctggtga ggaatgcctt ctccaacctg agtttggaaa tcgggaacat cactatcaca     1620



gccccttccg gtctccaaga accatctggg atgaatgctg aaggaaagag taaagataaa     1680



ggcgatatgg aggtgtacat ccaacctggt ccatatgtgg atcctttcac gacagtgacc     1740



ctgggctggc cagacaatga caaggagtta cgcttccaat ggtcatgtgg gtcttgctgg     1800



gctctgtgga gcagctgtgt tgagaggcag ctgcttcgca cagaccagag ggagctggtg     1860



gttccagcat cctgcctgcc gccgcctgac tctgctgtca ccctgcgcct ggctgttctg     1920



agaggccaag agctggagaa cagggcagag cagtgcctct acgtgtctgc gccctgggaa     1980



ctcaggcctc gagtcagctg tgagaggaac tgcaggccag ttaatgccag caaagacatt     2040



ctgctcaggg tcaccatggg ggaggactct ccagtggcta tgttcagctg gtatttggac     2100



aacaccccaa cagagcaggc tgagcccctc ctggatgcct gcagactcag aggattttgg     2160



ccaaggtcct taaccctcct ccagagcaac acctccacgt tgctgttgaa cagctcgttt     2220



ctgcagtccc ggggagaggt catccgaatc agagccacag cactgaccag gcatgcctat     2280



ggggaggaca cctatgtgat cagcactgtg cctccccgtg aggtgcctgc ctgcactatt     2340



gccccagagg agggcaccgt tctgacgagc tttgccatct tctgcaacgc ctccacagcc     2400



ctgggacccc tggagttctg cttctgtctg gaatcaggtt cctgcctaca ctgtggccct     2460



gaacctgccc tcccatcagt gtatctgcca cttggagagg agaacaatga ctttgtgctg     2520



acagtagtta tttctgccac caatcgtgca ggggacacgc agcagaccca ggccatggct     2580



aaggtggcac tcggagacac atgtgttgag gatgtagcat tccaggctgc cgtgtcagag     2640



aaaatcccca cagctctgca aggcgagggt ggccccgagc agctcctcca gctggccaag     2700



gctgtgtcct ccatgctgaa ccaagagcat gaaagccagg gctcaggaca gtcactgagc     2760



atagacgtca gacagaaggt cagagagcat gtgctgggat cactgtctgc agtcaccacc     2820



ggcttggagg acgtgcagag ggtgcaggag ctggccgagg tgctgagaga ggtgacctgc     2880



cggagtaagg aactcacacc ctcggcccag gggtcctgca tgggcgattc atgggaaggt     2940



gcccctcctg ctgcccatgt atctcacgct aggtgagagg gcctgtttgc ccagactctc     3000



actcctgcat ctgctggtga gcaagttgag ggagtaactg aatctcatta atatttgggt     3060



ggccaaatgt gagtccagac actgctactg actgcccatg ttctcaactt cagtacatgc     3120



cagcctgaca tctggctgcc agctcctgtg cttccttatc cttctggggg tcttctctga     3180



ccctcagagc ctactgtacc tgcccatatg gctgtgaatt catgcagtgt tcagtgacta     3240



atgaagctgg cttataaaca ccccagctac ctcacccctc ttgatggata atcccaagca     3300



ggagtgaatc ccaggtaatg ggcttgatca cactcctgta ctggcttcca cccttccctg     3360



tctcacaccc cctactcccc acaagtgttt cttgggatca tgtccaaata aatgacttgc     3420



tctcaaa                                                               3427





<210>  235

<211>  991

<212>  PRT

<213>  Homo sapiens



<400>  235



Met Ser Ala Val Gly Leu Val Leu Leu Val Leu Ala Leu Arg Leu Arg 

1               5                   10                  15      





Ala Thr Thr Val Lys Pro Glu Glu Gly Ser Phe Cys Ser Asn Ser Gln 

            20                  25                  30          





Val Ala Phe Arg Asp Ala Cys Tyr Glu Phe Val Pro Leu Gly Arg Thr 

        35                  40                  45              





Phe Arg Asp Ala Gln Ser Trp Cys Glu Gly Gln Gly Gly His Leu Val 

    50                  55                  60                  





Phe Ile Gln Asp Glu Gly Thr Gln Trp Phe Leu Gln Lys His Ile Ser 

65                  70                  75                  80  





Gln Asp Arg Glu Trp Trp Ile Gly Leu Thr Trp Asn Leu Ala Arg Asn 

                85                  90                  95      





Gly Thr Thr Glu Gly Pro Gly Thr Trp Leu Asp Thr Ser Asn Val Thr 

            100                 105                 110         





Tyr Ser Asn Trp His Gly Gly Gln Ala Ala Ala Ala Pro Asp Thr Cys 

        115                 120                 125             





Gly His Ile Gly Arg Gly Pro Ser Ser Glu Trp Val Thr Ser Asp Cys 

    130                 135                 140                 





Ala Gln Thr Phe Ala Phe Met Cys Glu Phe Arg Val Gly Gln Ser Leu 

145                 150                 155                 160 





Ala Cys Glu Gly Leu Asn Ala Thr Val His Cys Gly Leu Gly Gln Val 

                165                 170                 175     





Ile Gln Val Gln Asp Ala Val Tyr Gly Arg Gln Asn Pro His Phe Cys 

            180                 185                 190         





Thr Gln Asp Ala Gly Arg Pro Ser Asp Leu Glu Gln Gly Cys Ser Trp 

        195                 200                 205             





Ala Asn Val Lys Glu Glu Val Ala Gly Gln Cys Gln Glu Leu Gln Ser 

    210                 215                 220                 





Cys Gln Val Ala Ala Asp Glu Thr Tyr Phe Gly Asn Leu Cys Pro Thr 

225                 230                 235                 240 





Gln Gly Ser Tyr Leu Trp Val Gln Tyr Gln Cys Arg Glu Ala Leu Gln 

                245                 250                 255     





Leu Met Val Ser Ser Glu Ser Phe Ile Phe Asp Asn Val Thr Ile Ser 

            260                 265                 270         





Leu Thr Trp Leu Leu Ser Pro Tyr Ile Gly Asn Leu Ser Cys Ile Ile 

        275                 280                 285             





Ser Thr Gly Asp Ser His Thr Phe Asp Pro Tyr Asn Pro Pro Ser Val 

    290                 295                 300                 





Ser Ser Asn Val Thr His Gln Phe Thr Ser Pro Gly Glu Phe Thr Val 

305                 310                 315                 320 





Phe Ala Glu Cys Thr Thr Ser Glu Trp His Val Thr Ala Gln Arg Gln 

                325                 330                 335     





Val Thr Val Arg Asp Lys Met Glu Thr Leu Ser Val Thr Ala Cys Ser 

            340                 345                 350         





Gly Leu Ser Gln Ser Gly Ala Gly Pro Leu Cys Gln Ala Val Phe Gly 

        355                 360                 365             





Asp Pro Leu Trp Ile Gln Val Glu Leu Asp Gly Gly Thr Gly Val Thr 

    370                 375                 380                 





Tyr Thr Val Leu Leu Gly Asp Ile Thr Leu Ala Glu Ser Thr Thr Gln 

385                 390                 395                 400 





Lys Gly Ser Leu Pro Tyr Asn Leu Ile Leu Asp Arg Glu Thr Gln Lys 

                405                 410                 415     





Leu Met Gly Pro Gly Arg His Arg Leu Glu Ile Gln Ala Thr Gly Asn 

            420                 425                 430         





Thr Thr Thr Ser Thr Ile Ser Arg Asn Ile Thr Val His Leu Val Glu 

        435                 440                 445             





Leu Leu Ser Gly Leu Gln Ala Ser Trp Ala Ser Asp His Leu Glu Leu 

    450                 455                 460                 





Gly Gln Asp Leu Leu Ile Thr Ile Ser Leu Ala Gln Gly Thr Pro Glu 

465                 470                 475                 480 





Glu Leu Thr Phe Glu Val Ala Gly Leu Asn Ala Thr Phe Ser His Glu 

                485                 490                 495     





Gln Val Ser Phe Gly Glu Pro Phe Gly Ile Cys Arg Leu Ala Val Pro 

            500                 505                 510         





Val Glu Gly Thr Phe Leu Val Thr Met Leu Val Arg Asn Ala Phe Ser 

        515                 520                 525             





Asn Leu Ser Leu Glu Ile Gly Asn Ile Thr Ile Thr Ala Pro Ser Gly 

    530                 535                 540                 





Leu Gln Glu Pro Ser Gly Met Asn Ala Glu Gly Lys Ser Lys Asp Lys 

545                 550                 555                 560 





Gly Asp Met Glu Val Tyr Ile Gln Pro Gly Pro Tyr Val Asp Pro Phe 

                565                 570                 575     





Thr Thr Val Thr Leu Gly Trp Pro Asp Asn Asp Lys Glu Leu Arg Phe 

            580                 585                 590         





Gln Trp Ser Cys Gly Ser Cys Trp Ala Leu Trp Ser Ser Cys Val Glu 

        595                 600                 605             





Arg Gln Leu Leu Arg Thr Asp Gln Arg Glu Leu Val Val Pro Ala Ser 

    610                 615                 620                 





Cys Leu Pro Pro Pro Asp Ser Ala Val Thr Leu Arg Leu Ala Val Leu 

625                 630                 635                 640 





Arg Gly Gln Glu Leu Glu Asn Arg Ala Glu Gln Cys Leu Tyr Val Ser 

                645                 650                 655     





Ala Pro Trp Glu Leu Arg Pro Arg Val Ser Cys Glu Arg Asn Cys Arg 

            660                 665                 670         





Pro Val Asn Ala Ser Lys Asp Ile Leu Leu Arg Val Thr Met Gly Glu 

        675                 680                 685             





Asp Ser Pro Val Ala Met Phe Ser Trp Tyr Leu Asp Asn Thr Pro Thr 

    690                 695                 700                 





Glu Gln Ala Glu Pro Leu Leu Asp Ala Cys Arg Leu Arg Gly Phe Trp 

705                 710                 715                 720 





Pro Arg Ser Leu Thr Leu Leu Gln Ser Asn Thr Ser Thr Leu Leu Leu 

                725                 730                 735     





Asn Ser Ser Phe Leu Gln Ser Arg Gly Glu Val Ile Arg Ile Arg Ala 

            740                 745                 750         





Thr Ala Leu Thr Arg His Ala Tyr Gly Glu Asp Thr Tyr Val Ile Ser 

        755                 760                 765             





Thr Val Pro Pro Arg Glu Val Pro Ala Cys Thr Ile Ala Pro Glu Glu 

    770                 775                 780                 





Gly Thr Val Leu Thr Ser Phe Ala Ile Phe Cys Asn Ala Ser Thr Ala 

785                 790                 795                 800 





Leu Gly Pro Leu Glu Phe Cys Phe Cys Leu Glu Ser Gly Ser Cys Leu 

                805                 810                 815     





His Cys Gly Pro Glu Pro Ala Leu Pro Ser Val Tyr Leu Pro Leu Gly 

            820                 825                 830         





Glu Glu Asn Asn Asp Phe Val Leu Thr Val Val Ile Ser Ala Thr Asn 

        835                 840                 845             





Arg Ala Gly Asp Thr Gln Gln Thr Gln Ala Met Ala Lys Val Ala Leu 

    850                 855                 860                 





Gly Asp Thr Cys Val Glu Asp Val Ala Phe Gln Ala Ala Val Ser Glu 

865                 870                 875                 880 





Lys Ile Pro Thr Ala Leu Gln Gly Glu Gly Gly Pro Glu Gln Leu Leu 

                885                 890                 895     





Gln Leu Ala Lys Ala Val Ser Ser Met Leu Asn Gln Glu His Glu Ser 

            900                 905                 910         





Gln Gly Ser Gly Gln Ser Leu Ser Ile Asp Val Arg Gln Lys Val Arg 

        915                 920                 925             





Glu His Val Leu Gly Ser Leu Ser Ala Val Thr Thr Gly Leu Glu Asp 

    930                 935                 940                 





Val Gln Arg Val Gln Glu Leu Ala Glu Val Leu Arg Glu Val Thr Cys 

945                 950                 955                 960 





Arg Ser Lys Glu Leu Thr Pro Ser Ala Gln Gly Ser Cys Met Gly Asp 

                965                 970                 975     





Ser Trp Glu Gly Ala Pro Pro Ala Ala His Val Ser His Ala Arg 

            980                 985                 990     





<210>  236

<211>  7624

<212>  DNA

<213>  Homo sapiens



<400>  236

atgagtgcag tgggcttggt actcctggtg cttgctctga ggcttagggc caccactgtt       60



aagccagagg aaggcagctt ttgctctaac agccaggtgg ccttcagaga tgcttgctat      120



gaatttgtgc cactcggacg caccttccgt gatgcccaga gctggtgcga ggggcaagga      180



ggccatttgg tcttcattca ggacgaaggc acccagtggt ttctgcagaa gcacatctcc      240



caggacaggg aatggtggat tggactcacg tggaacttgg cacggaatgg aaccacggag      300



gggccgggga cttggttgga cacctccaat gtgacctaca gcaactggca tggagggcag      360



gccgccgctg cccctgacac ctgcggccac atcgggagag gcccttcctc tgagtgggtg      420



acctcggact gcgcccagac cttcgccttc atgtgcgagt tccgggttgg ccagagcctg      480



gcctgcgagg gactcaatgc caccgtgcac tgtggcttgg ggcaggtcat ccaggtccag      540



gatgccgtct acgggcgcca gaatccccat ttctgcaccc aggatgccgg gcgtccttca      600



gatctggagc agggatgcag ctgggccaac gtcaaggagg aggtggcagg ccagtgccag      660



gagctacagt catgccaggt ggcagcagat gagacctact ttggaaacct gtgtccgact      720



cagggcagtt acctgtgggt gcagtaccag tgccgggaag ccctgcagct gatggtgtcc      780



agtgagagtt tcatctttga caatgtcacc atctccctga cgtggctcct ctcaccctac      840



ataggaaacc tgtcctgtat aattagtaca ggagacagcc acacttttga tccctacaac      900



ccgccgagtg tgtccagcaa tgtgacccac cagttcacat ctcctgggga attcaccgtg      960



tttgctgaat gcacaaccag tgagtggcat gtgacagctc agaggcaggt gaccgtgcga     1020



gacaagatgg agacgctcag tgtgactgca tgctccggcc tgtcccagtc aggagccggc     1080



cctctctgcc aggctgtctt tggggatcct ctgtggattc aggtggagct tgatggagga     1140



acaggagtga cttacactgt gcttttgggt gacataaccc tggccgagtc caccacccaa     1200



aagggctcgc taccgtacaa tctgatcctg gacagagaaa cccagaaact gatgggccct     1260



gggaggcacc gcctggagat ccaagccacc ggcaacacca ccacctctac aatctccaga     1320



aacattacag tccacttggt ggagctgctg tcagggctgc aggcctcctg ggcttctgac     1380



catttggagc ttggacagga cctattgatc accatctcat tggctcaggg caccccggaa     1440



gagctgacct ttgaggtggc tggactcaat gcaaccttct cccacgagca agtgagcttt     1500



ggagagccat ttgggatttg ccgcctggct gttccggttg aaggcacctt tctggtcacc     1560



atgctggtga ggaatgcctt ctccaacctg agtttggaaa tcgggaacat cactatcaca     1620



gccccttccg gtctccaaga accatctggg atgaatgctg aaggaaagag taaagataaa     1680



ggcgatatgg aggtgtacat ccaacctggt ccatatgtgg atcctttcac gacagtgacc     1740



ctgggctggc cagacaatga caaggagtta cgcttccaat ggtcatgtgg gtcttgctgg     1800



gctctgtgga gcagctgtgt tgagaggcag ctgcttcgca cagaccagag ggagctggtg     1860



gttccagcat cctgcctgcc gccgcctgac tctgctgtca ccctgcgcct ggctgttctg     1920



agaggccaag agctggagaa cagggcagag cagtgcctct acgtgtctgc gccctgggaa     1980



ctcaggcctc gagtcagctg tgagaggaac tgcaggccag ttaatgccag caaagacatt     2040



ctgctcaggg tcaccatggg ggaggactct ccagtggcta tgttcagctg gtatttggac     2100



aacaccccaa cagagcaggc tgagcccctc ctggatgcct gcagactcag aggattttgg     2160



ccaaggtcct taaccctcct ccagagcaac acctccacgt tgctgttgaa cagctcgttt     2220



ctgcagtccc ggggagaggt catccgaatc agagccacag cactgaccag gcatgcctat     2280



ggggaggaca cctatgtgat cagcactgtg cctccccgtg aggtgcctgc ctgcactatt     2340



gccccagagg agggcaccgt tctgacgagc tttgccatct tctgcaacgc ctccacagcc     2400



ctgggacccc tggagttctg cttctgtctg gaatcaggtt cctgcctaca ctgtggccct     2460



gaacctgccc tcccatcagt gtatctgcca cttggagagg agaacaatga ctttgtgctg     2520



acagtagtta tttctgccac caatcgtgca ggggacacgc agcagaccca ggccatggct     2580



aaggtggcac tcggagacac atgtgttgag gatgtagcat tccaggctgc cgtgtcagag     2640



aaaatcccca cagctctgca aggcgagggt ggccccgagc agctcctcca gctggccaag     2700



gctgtgtcct ccatgctgaa ccaagagcat gaaagccagg gctcaggaca gtcactgagc     2760



atagacgtca gacagaaggt cagagagcat gtgctgggat cactgtctgc agtcaccacc     2820



ggcttggagg acgtgcagag ggtgcaggag ctggccgagg tgctgagaga ggtgacctgc     2880



cggagtaagg aactcacacc ctcggcccag tgggaggcca gcttggctct acagcatgcc     2940



agtgaggccc tgttgacagt gagtgccaag gcccgccctg aggaccagag gcgccaggca     3000



gccaccaggg acctgtttca ggctgtgggc agtgtgctgg aagcttccct gagcaacaga     3060



ccagaagagc ctgcggaggc cagcagcagc cagattgcca cagtgctgcg gctgcttcga     3120



gtcatggagc atgtgcagac caccctcctg ctgggaaaac tgccaggggg ccttccagcc     3180



atgctggcca ccccctccat ctctgtgtac acaaacagaa tacaaccctg gagttggcaa     3240



ggctcctccc tgcgccctga tgccgcagac tctgcaacct tcatgctgcc cgctgcctcc     3300



tccctcagct ctctggaggg cggccaggag cccgtggata taaagatcat gagtttccca     3360



aagagcccct ttccagcccg aagccacttt gatgtcagcg ggactgtcgg tggcctccgt     3420



gtgaccagcc ctagtggtca actcatacct gtgaagaatc tgtcggagaa tatcgagatc     3480



ctgctgcccc ggcattcaca aagacacagc cagccgaccg tgttgaacct gaccagtcct     3540



gaagctttgt gggtgaacgt gacttcaggg gaggcaacct tggggatcca gctgcactgg     3600



agaccagaca ttgcactcac gcttagcctg ggctatggct accaccccaa caagagcagc     3660



tacgatgccc aaactcacct cgtaccaatg gtggctccag atgagctgcc cacgtggatc     3720



ctgagcccac aggacctgcg ttttggagaa ggggtctact atttgactgt ggtccctgag     3780



tctgacctgg agccagcccc cggcagggac ctcacggttg gcatcaccac cttcctgtct     3840



cactgtgtgt tctgggatga ggtccaggag acttgggacg actcaggatg ccaggtgggg     3900



cctcggacca gcccctacca gacacactgc ctctgcaacc acctcacttt cttcggaagc     3960



acgttcctgg tgatgtccaa tgccatcaac atccaccaga ctgctgagct ctttgccacc     4020



tttgaggaca accctgtggt cgtgaccacc gtgggctgcc tgtgtgtggt ctacgtgctg     4080



gtggtgatct gggcgaggag gaaggacgct caggatcagg ccaaggtgaa ggtcacagtg     4140



ctggaagaca atgatccctt tgctcagtac cactacctgg tgacagtcta cacaggacac     4200



cgacgagggg cagccacgtc ctcaaaggtg actgtcaccc tgtatggcct ggatggagag     4260



agagagcccc accacctggc tgatcccgac actccggttt ttgagcgagg agcagtggat     4320



gccttcctcc tctccaccct gttccccctg ggagaactgc ggagcctccg gctgtggcat     4380



gacaactcag gggaccggcc atcgtggtat gtgagccggg tgctggtcta tgacctggtg     4440



atggaccgga agtggtattt cctgtgcaac tcctggctat ccatcaatgt tggagattgc     4500



gtcctcgata aggtgtttcc tgtggccacg gagcaggaca gaaaacaatt cagccacctg     4560



tttttcatga agacttccgc gggcttccag gatggacaca tctggtattc gatcttcagc     4620



cgctgcgctc gcagcagctt cacccgcgtc cagagggtgt cctgctgctt ctccctgctg     4680



ctgtgcacca tgctgaccag catcatgttc tggggggtcc ccaaggaccc agctgagcaa     4740



aagatggact tgggtaaaat tgaattcacc tggcaggagg tgatgattgg cctggagagc     4800



tccatcctca tgttccccat caacctcctg attgttcaga tctttcagaa cacccgtccc     4860



cgggtcgcga aggagcagaa cactggaaaa tgggaccggg ggtcccccaa cctgactccc     4920



tccccacagc ccatggagga cggccttctg acacctgagg cagtgaccaa ggatgtgtca     4980



agaatcgtca gctccctctt caaagctctc aaggtgccat cccccgcctt gggctgggac     5040



tcagtgaact tgatggacat caacagtctc ctcgccttgg tggaagatgt catttatcca     5100



cagaacacat cagggcaggt gttctgggag gaagccaaaa agagagagga ccctgtaaca     5160



ctcactttgg ggtcatcaga aatgaaagag aaatcacagt gtcccaagcc caaggcggca     5220



cggagtggcc cctggaagga cagcgcctac aggcagtgtc tgtaccttca gctggaacac     5280



gtggagcaag agctgcggct ggtggggccc cgaggcttct cccagcccca cagccatgcc     5340



caggccctca ggcagctgca gaccctgaag ggcggcctgg gggtacagcc gggcacctgg     5400



gcccctgcac atgccagcgc tcttcaggtg agcaaacccc ctcaaggcct gccctggtgg     5460



tgcatcctgg tgggctggct cctggtagcg gccaccagtg gcgtggcggc cttcttcacc     5520



atgctctacg gcctgcacta cgggagggcc agctccctca ggtggctcat ctccatggct     5580



gtctccttcg tggagagcat gttcgtcacc cagcccctga aggtgctggg attcgctgct     5640



ttctttgcac tggtcttgaa gagagtggac gatgaggagg atactgtggc cccgctgcca     5700



ggacatctgt tgggcccaga cccctatgcc ttgttccgag cacgaagaaa cagcagcagg     5760



gatgtctacc agccacctct caccgctgcc attgagaaga tgaaaaccac ccacctcaag     5820



gaacagaaag catttgccct catcagagaa atcctggcat acttgggctt cctgtggatg     5880



ctactgctcg tggcctacgg gcagagggac cccagcgcct accacctcaa cagacacctc     5940



cagcacagct tcaccagggg cttttcaggt gtgctcggct tccgagagtt cttcaagtgg     6000



gccaacacca ccctcgtgag taacctgtat ggtcaccccc caggctttat cactgatggg     6060



aactccaagc tggttggcag tgcccagatt cgtcaagtga gggtccagga aagctcttgc     6120



cctcttgccc agcagccgca ggcatatctc aacggatgcc gtgcaccata ttccctggat     6180



gctgaagaca tggcagacta tggggaaggc tggaatgcca ccaccctcag tgaatggcag     6240



taccagagcc aggaccaacg tcaagggtat cccatctggg gcaaactcac tgtgtaccgg     6300



ggaggaggct acgtggtccc cttggggact gatcgccaaa gcacgtcaag aattctccgc     6360



tatctctttg acaacacctg gctggacgcc ctgaccagag ctgtgtttgt ggagtccact     6420



gtctacaacg ccaacgtcaa cctgttctgc attgtcacgc tgacgctaga gaccagcgct     6480



ctgggcacct tttttacgca cgcggccctg cagagcctcc gcctgtaccc cttcaccgac     6540



ggctggcacc ccttcgtggt agcggcagag ctcatctact tcctcttcct cctctactac     6600



atggtggtgc agggcaagcg catgagtaaa gagacgtggg gctatttctg cagcaagtgg     6660



aaccttctgg agctggccat catcctggcc agctggagcg ccctggcggt gtttgtgaag     6720



agggctgtcc tggccgaaag ggacctccag cgctgccgga accacaggga ggaaggcatc     6780



agcttcagtg agacagcagc agccgatgcc gcccttggct acatcattgc cttcctggta     6840



ctcctgtcca cagtgaagct ttggcatctg ctcaggttga atcccaaaat gaacatgatc     6900



acggcagccc tacgccgtgc ctggggcgac atttcaggct ttatgattgt catccttacc     6960



atgctcctgg cttactccat cgcgtcaaac ttgatatttg gttggaaact ccgttcctac     7020



aaaaccctct ttgatgcggc ggagacgatg gtcagccttc agctgggaat cttcaactac     7080



gaggaggtcc tggactatag cccagtgctt ggctccttcc tcattggatc ctgcattgtt     7140



tttatgacat ttgtggtgct gaacctgttt atctctgtca tcctggtggc cttcagtgag     7200



gagcaaaaat actatcagct gtcggaggaa ggggagatcg tagatttgct gctgatgaaa     7260



atactcagtt tcctgggcat taagtctaag agagaggagc ctggaagcag cagggagcag     7320



cctgggtctc tgtcccagac tcgccactct cgaccagcac aagctttgcc caaggactaa     7380



gctgttcgtc cacacgccac catctaccag tggggacgcc cagggcctcg ggcgtacgct     7440



taccagcgac tctatagtct ctctaggtca tagctttcat gtccattgaa gaattaccaa     7500



gcccagcaag taaaaaaaat tacaataaca gagatatatg taaaattgcc aatactatga     7560



gagcttcttt gttcaaatgt atttcctctt attataaata aaacaaatat tacatggagt     7620



ttgg                                                                  7624





<210>  237

<211>  2459

<212>  PRT

<213>  Homo sapiens



<400>  237



Met Ser Ala Val Gly Leu Val Leu Leu Val Leu Ala Leu Arg Leu Arg 

1               5                   10                  15      





Ala Thr Thr Val Lys Pro Glu Glu Gly Ser Phe Cys Ser Asn Ser Gln 

            20                  25                  30          





Val Ala Phe Arg Asp Ala Cys Tyr Glu Phe Val Pro Leu Gly Arg Thr 

        35                  40                  45              





Phe Arg Asp Ala Gln Ser Trp Cys Glu Gly Gln Gly Gly His Leu Val 

    50                  55                  60                  





Phe Ile Gln Asp Glu Gly Thr Gln Trp Phe Leu Gln Lys His Ile Ser 

65                  70                  75                  80  





Gln Asp Arg Glu Trp Trp Ile Gly Leu Thr Trp Asn Leu Ala Arg Asn 

                85                  90                  95      





Gly Thr Thr Glu Gly Pro Gly Thr Trp Leu Asp Thr Ser Asn Val Thr 

            100                 105                 110         





Tyr Ser Asn Trp His Gly Gly Gln Ala Ala Ala Ala Pro Asp Thr Cys 

        115                 120                 125             





Gly His Ile Gly Arg Gly Pro Ser Ser Glu Trp Val Thr Ser Asp Cys 

    130                 135                 140                 





Ala Gln Thr Phe Ala Phe Met Cys Glu Phe Arg Val Gly Gln Ser Leu 

145                 150                 155                 160 





Ala Cys Glu Gly Leu Asn Ala Thr Val His Cys Gly Leu Gly Gln Val 

                165                 170                 175     





Ile Gln Val Gln Asp Ala Val Tyr Gly Arg Gln Asn Pro His Phe Cys 

            180                 185                 190         





Thr Gln Asp Ala Gly Arg Pro Ser Asp Leu Glu Gln Gly Cys Ser Trp 

        195                 200                 205             





Ala Asn Val Lys Glu Glu Val Ala Gly Gln Cys Gln Glu Leu Gln Ser 

    210                 215                 220                 





Cys Gln Val Ala Ala Asp Glu Thr Tyr Phe Gly Asn Leu Cys Pro Thr 

225                 230                 235                 240 





Gln Gly Ser Tyr Leu Trp Val Gln Tyr Gln Cys Arg Glu Ala Leu Gln 

                245                 250                 255     





Leu Met Val Ser Ser Glu Ser Phe Ile Phe Asp Asn Val Thr Ile Ser 

            260                 265                 270         





Leu Thr Trp Leu Leu Ser Pro Tyr Ile Gly Asn Leu Ser Cys Ile Ile 

        275                 280                 285             





Ser Thr Gly Asp Ser His Thr Phe Asp Pro Tyr Asn Pro Pro Ser Val 

    290                 295                 300                 





Ser Ser Asn Val Thr His Gln Phe Thr Ser Pro Gly Glu Phe Thr Val 

305                 310                 315                 320 





Phe Ala Glu Cys Thr Thr Ser Glu Trp His Val Thr Ala Gln Arg Gln 

                325                 330                 335     





Val Thr Val Arg Asp Lys Met Glu Thr Leu Ser Val Thr Ala Cys Ser 

            340                 345                 350         





Gly Leu Ser Gln Ser Gly Ala Gly Pro Leu Cys Gln Ala Val Phe Gly 

        355                 360                 365             





Asp Pro Leu Trp Ile Gln Val Glu Leu Asp Gly Gly Thr Gly Val Thr 

    370                 375                 380                 





Tyr Thr Val Leu Leu Gly Asp Ile Thr Leu Ala Glu Ser Thr Thr Gln 

385                 390                 395                 400 





Lys Gly Ser Leu Pro Tyr Asn Leu Ile Leu Asp Arg Glu Thr Gln Lys 

                405                 410                 415     





Leu Met Gly Pro Gly Arg His Arg Leu Glu Ile Gln Ala Thr Gly Asn 

            420                 425                 430         





Thr Thr Thr Ser Thr Ile Ser Arg Asn Ile Thr Val His Leu Val Glu 

        435                 440                 445             





Leu Leu Ser Gly Leu Gln Ala Ser Trp Ala Ser Asp His Leu Glu Leu 

    450                 455                 460                 





Gly Gln Asp Leu Leu Ile Thr Ile Ser Leu Ala Gln Gly Thr Pro Glu 

465                 470                 475                 480 





Glu Leu Thr Phe Glu Val Ala Gly Leu Asn Ala Thr Phe Ser His Glu 

                485                 490                 495     





Gln Val Ser Phe Gly Glu Pro Phe Gly Ile Cys Arg Leu Ala Val Pro 

            500                 505                 510         





Val Glu Gly Thr Phe Leu Val Thr Met Leu Val Arg Asn Ala Phe Ser 

        515                 520                 525             





Asn Leu Ser Leu Glu Ile Gly Asn Ile Thr Ile Thr Ala Pro Ser Gly 

    530                 535                 540                 





Leu Gln Glu Pro Ser Gly Met Asn Ala Glu Gly Lys Ser Lys Asp Lys 

545                 550                 555                 560 





Gly Asp Met Glu Val Tyr Ile Gln Pro Gly Pro Tyr Val Asp Pro Phe 

                565                 570                 575     





Thr Thr Val Thr Leu Gly Trp Pro Asp Asn Asp Lys Glu Leu Arg Phe 

            580                 585                 590         





Gln Trp Ser Cys Gly Ser Cys Trp Ala Leu Trp Ser Ser Cys Val Glu 

        595                 600                 605             





Arg Gln Leu Leu Arg Thr Asp Gln Arg Glu Leu Val Val Pro Ala Ser 

    610                 615                 620                 





Cys Leu Pro Pro Pro Asp Ser Ala Val Thr Leu Arg Leu Ala Val Leu 

625                 630                 635                 640 





Arg Gly Gln Glu Leu Glu Asn Arg Ala Glu Gln Cys Leu Tyr Val Ser 

                645                 650                 655     





Ala Pro Trp Glu Leu Arg Pro Arg Val Ser Cys Glu Arg Asn Cys Arg 

            660                 665                 670         





Pro Val Asn Ala Ser Lys Asp Ile Leu Leu Arg Val Thr Met Gly Glu 

        675                 680                 685             





Asp Ser Pro Val Ala Met Phe Ser Trp Tyr Leu Asp Asn Thr Pro Thr 

    690                 695                 700                 





Glu Gln Ala Glu Pro Leu Leu Asp Ala Cys Arg Leu Arg Gly Phe Trp 

705                 710                 715                 720 





Pro Arg Ser Leu Thr Leu Leu Gln Ser Asn Thr Ser Thr Leu Leu Leu 

                725                 730                 735     





Asn Ser Ser Phe Leu Gln Ser Arg Gly Glu Val Ile Arg Ile Arg Ala 

            740                 745                 750         





Thr Ala Leu Thr Arg His Ala Tyr Gly Glu Asp Thr Tyr Val Ile Ser 

        755                 760                 765             





Thr Val Pro Pro Arg Glu Val Pro Ala Cys Thr Ile Ala Pro Glu Glu 

    770                 775                 780                 





Gly Thr Val Leu Thr Ser Phe Ala Ile Phe Cys Asn Ala Ser Thr Ala 

785                 790                 795                 800 





Leu Gly Pro Leu Glu Phe Cys Phe Cys Leu Glu Ser Gly Ser Cys Leu 

                805                 810                 815     





His Cys Gly Pro Glu Pro Ala Leu Pro Ser Val Tyr Leu Pro Leu Gly 

            820                 825                 830         





Glu Glu Asn Asn Asp Phe Val Leu Thr Val Val Ile Ser Ala Thr Asn 

        835                 840                 845             





Arg Ala Gly Asp Thr Gln Gln Thr Gln Ala Met Ala Lys Val Ala Leu 

    850                 855                 860                 





Gly Asp Thr Cys Val Glu Asp Val Ala Phe Gln Ala Ala Val Ser Glu 

865                 870                 875                 880 





Lys Ile Pro Thr Ala Leu Gln Gly Glu Gly Gly Pro Glu Gln Leu Leu 

                885                 890                 895     





Gln Leu Ala Lys Ala Val Ser Ser Met Leu Asn Gln Glu His Glu Ser 

            900                 905                 910         





Gln Gly Ser Gly Gln Ser Leu Ser Ile Asp Val Arg Gln Lys Val Arg 

        915                 920                 925             





Glu His Val Leu Gly Ser Leu Ser Ala Val Thr Thr Gly Leu Glu Asp 

    930                 935                 940                 





Val Gln Arg Val Gln Glu Leu Ala Glu Val Leu Arg Glu Val Thr Cys 

945                 950                 955                 960 





Arg Ser Lys Glu Leu Thr Pro Ser Ala Gln Trp Glu Ala Ser Leu Ala 

                965                 970                 975     





Leu Gln His Ala Ser Glu Ala Leu Leu Thr Val Ser Ala Lys Ala Arg 

            980                 985                 990         





Pro Glu Asp Gln Arg Arg Gln Ala  Ala Thr Arg Asp Leu  Phe Gln Ala 

        995                 1000                 1005             





Val Gly  Ser Val Leu Glu Ala  Ser Leu Ser Asn Arg  Pro Glu Glu 

    1010                 1015                 1020             





Pro Ala  Glu Ala Ser Ser Ser  Gln Ile Ala Thr Val  Leu Arg Leu 

    1025                 1030                 1035             





Leu Arg  Val Met Glu His Val  Gln Thr Thr Leu Leu  Leu Gly Lys 

    1040                 1045                 1050             





Leu Pro  Gly Gly Leu Pro Ala  Met Leu Ala Thr Pro  Ser Ile Ser 

    1055                 1060                 1065             





Val Tyr  Thr Asn Arg Ile Gln  Pro Trp Ser Trp Gln  Gly Ser Ser 

    1070                 1075                 1080             





Leu Arg  Pro Asp Ala Ala Asp  Ser Ala Thr Phe Met  Leu Pro Ala 

    1085                 1090                 1095             





Ala Ser  Ser Leu Ser Ser Leu  Glu Gly Gly Gln Glu  Pro Val Asp 

    1100                 1105                 1110             





Ile Lys  Ile Met Ser Phe Pro  Lys Ser Pro Phe Pro  Ala Arg Ser 

    1115                 1120                 1125             





His Phe  Asp Val Ser Gly Thr  Val Gly Gly Leu Arg  Val Thr Ser 

    1130                 1135                 1140             





Pro Ser  Gly Gln Leu Ile Pro  Val Lys Asn Leu Ser  Glu Asn Ile 

    1145                 1150                 1155             





Glu Ile  Leu Leu Pro Arg His  Ser Gln Arg His Ser  Gln Pro Thr 

    1160                 1165                 1170             





Val Leu  Asn Leu Thr Ser Pro  Glu Ala Leu Trp Val  Asn Val Thr 

    1175                 1180                 1185             





Ser Gly  Glu Ala Thr Leu Gly  Ile Gln Leu His Trp  Arg Pro Asp 

    1190                 1195                 1200             





Ile Ala  Leu Thr Leu Ser Leu  Gly Tyr Gly Tyr His  Pro Asn Lys 

    1205                 1210                 1215             





Ser Ser  Tyr Asp Ala Gln Thr  His Leu Val Pro Met  Val Ala Pro 

    1220                 1225                 1230             





Asp Glu  Leu Pro Thr Trp Ile  Leu Ser Pro Gln Asp  Leu Arg Phe 

    1235                 1240                 1245             





Gly Glu  Gly Val Tyr Tyr Leu  Thr Val Val Pro Glu  Ser Asp Leu 

    1250                 1255                 1260             





Glu Pro  Ala Pro Gly Arg Asp  Leu Thr Val Gly Ile  Thr Thr Phe 

    1265                 1270                 1275             





Leu Ser  His Cys Val Phe Trp  Asp Glu Val Gln Glu  Thr Trp Asp 

    1280                 1285                 1290             





Asp Ser  Gly Cys Gln Val Gly  Pro Arg Thr Ser Pro  Tyr Gln Thr 

    1295                 1300                 1305             





His Cys  Leu Cys Asn His Leu  Thr Phe Phe Gly Ser  Thr Phe Leu 

    1310                 1315                 1320             





Val Met  Ser Asn Ala Ile Asn  Ile His Gln Thr Ala  Glu Leu Phe 

    1325                 1330                 1335             





Ala Thr  Phe Glu Asp Asn Pro  Val Val Val Thr Thr  Val Gly Cys 

    1340                 1345                 1350             





Leu Cys  Val Val Tyr Val Leu  Val Val Ile Trp Ala  Arg Arg Lys 

    1355                 1360                 1365             





Asp Ala  Gln Asp Gln Ala Lys  Val Lys Val Thr Val  Leu Glu Asp 

    1370                 1375                 1380             





Asn Asp  Pro Phe Ala Gln Tyr  His Tyr Leu Val Thr  Val Tyr Thr 

    1385                 1390                 1395             





Gly His  Arg Arg Gly Ala Ala  Thr Ser Ser Lys Val  Thr Val Thr 

    1400                 1405                 1410             





Leu Tyr  Gly Leu Asp Gly Glu  Arg Glu Pro His His  Leu Ala Asp 

    1415                 1420                 1425             





Pro Asp  Thr Pro Val Phe Glu  Arg Gly Ala Val Asp  Ala Phe Leu 

    1430                 1435                 1440             





Leu Ser  Thr Leu Phe Pro Leu  Gly Glu Leu Arg Ser  Leu Arg Leu 

    1445                 1450                 1455             





Trp His  Asp Asn Ser Gly Asp  Arg Pro Ser Trp Tyr  Val Ser Arg 

    1460                 1465                 1470             





Val Leu  Val Tyr Asp Leu Val  Met Asp Arg Lys Trp  Tyr Phe Leu 

    1475                 1480                 1485             





Cys Asn  Ser Trp Leu Ser Ile  Asn Val Gly Asp Cys  Val Leu Asp 

    1490                 1495                 1500             





Lys Val  Phe Pro Val Ala Thr  Glu Gln Asp Arg Lys  Gln Phe Ser 

    1505                 1510                 1515             





His Leu  Phe Phe Met Lys Thr  Ser Ala Gly Phe Gln  Asp Gly His 

    1520                 1525                 1530             





Ile Trp  Tyr Ser Ile Phe Ser  Arg Cys Ala Arg Ser  Ser Phe Thr 

    1535                 1540                 1545             





Arg Val  Gln Arg Val Ser Cys  Cys Phe Ser Leu Leu  Leu Cys Thr 

    1550                 1555                 1560             





Met Leu  Thr Ser Ile Met Phe  Trp Gly Val Pro Lys  Asp Pro Ala 

    1565                 1570                 1575             





Glu Gln  Lys Met Asp Leu Gly  Lys Ile Glu Phe Thr  Trp Gln Glu 

    1580                 1585                 1590             





Val Met  Ile Gly Leu Glu Ser  Ser Ile Leu Met Phe  Pro Ile Asn 

    1595                 1600                 1605             





Leu Leu  Ile Val Gln Ile Phe  Gln Asn Thr Arg Pro  Arg Val Ala 

    1610                 1615                 1620             





Lys Glu  Gln Asn Thr Gly Lys  Trp Asp Arg Gly Ser  Pro Asn Leu 

    1625                 1630                 1635             





Thr Pro  Ser Pro Gln Pro Met  Glu Asp Gly Leu Leu  Thr Pro Glu 

    1640                 1645                 1650             





Ala Val  Thr Lys Asp Val Ser  Arg Ile Val Ser Ser  Leu Phe Lys 

    1655                 1660                 1665             





Ala Leu  Lys Val Pro Ser Pro  Ala Leu Gly Trp Asp  Ser Val Asn 

    1670                 1675                 1680             





Leu Met  Asp Ile Asn Ser Leu  Leu Ala Leu Val Glu  Asp Val Ile 

    1685                 1690                 1695             





Tyr Pro  Gln Asn Thr Ser Gly  Gln Val Phe Trp Glu  Glu Ala Lys 

    1700                 1705                 1710             





Lys Arg  Glu Asp Pro Val Thr  Leu Thr Leu Gly Ser  Ser Glu Met 

    1715                 1720                 1725             





Lys Glu  Lys Ser Gln Cys Pro  Lys Pro Lys Ala Ala  Arg Ser Gly 

    1730                 1735                 1740             





Pro Trp  Lys Asp Ser Ala Tyr  Arg Gln Cys Leu Tyr  Leu Gln Leu 

    1745                 1750                 1755             





Glu His  Val Glu Gln Glu Leu  Arg Leu Val Gly Pro  Arg Gly Phe 

    1760                 1765                 1770             





Ser Gln  Pro His Ser His Ala  Gln Ala Leu Arg Gln  Leu Gln Thr 

    1775                 1780                 1785             





Leu Lys  Gly Gly Leu Gly Val  Gln Pro Gly Thr Trp  Ala Pro Ala 

    1790                 1795                 1800             





His Ala  Ser Ala Leu Gln Val  Ser Lys Pro Pro Gln  Gly Leu Pro 

    1805                 1810                 1815             





Trp Trp  Cys Ile Leu Val Gly  Trp Leu Leu Val Ala  Ala Thr Ser 

    1820                 1825                 1830             





Gly Val  Ala Ala Phe Phe Thr  Met Leu Tyr Gly Leu  His Tyr Gly 

    1835                 1840                 1845             





Arg Ala  Ser Ser Leu Arg Trp  Leu Ile Ser Met Ala  Val Ser Phe 

    1850                 1855                 1860             





Val Glu  Ser Met Phe Val Thr  Gln Pro Leu Lys Val  Leu Gly Phe 

    1865                 1870                 1875             





Ala Ala  Phe Phe Ala Leu Val  Leu Lys Arg Val Asp  Asp Glu Glu 

    1880                 1885                 1890             





Asp Thr  Val Ala Pro Leu Pro  Gly His Leu Leu Gly  Pro Asp Pro 

    1895                 1900                 1905             





Tyr Ala  Leu Phe Arg Ala Arg  Arg Asn Ser Ser Arg  Asp Val Tyr 

    1910                 1915                 1920             





Gln Pro  Pro Leu Thr Ala Ala  Ile Glu Lys Met Lys  Thr Thr His 

    1925                 1930                 1935             





Leu Lys  Glu Gln Lys Ala Phe  Ala Leu Ile Arg Glu  Ile Leu Ala 

    1940                 1945                 1950             





Tyr Leu  Gly Phe Leu Trp Met  Leu Leu Leu Val Ala  Tyr Gly Gln 

    1955                 1960                 1965             





Arg Asp  Pro Ser Ala Tyr His  Leu Asn Arg His Leu  Gln His Ser 

    1970                 1975                 1980             





Phe Thr  Arg Gly Phe Ser Gly  Val Leu Gly Phe Arg  Glu Phe Phe 

    1985                 1990                 1995             





Lys Trp  Ala Asn Thr Thr Leu  Val Ser Asn Leu Tyr  Gly His Pro 

    2000                 2005                 2010             





Pro Gly  Phe Ile Thr Asp Gly  Asn Ser Lys Leu Val  Gly Ser Ala 

    2015                 2020                 2025             





Gln Ile  Arg Gln Val Arg Val  Gln Glu Ser Ser Cys  Pro Leu Ala 

    2030                 2035                 2040             





Gln Gln  Pro Gln Ala Tyr Leu  Asn Gly Cys Arg Ala  Pro Tyr Ser 

    2045                 2050                 2055             





Leu Asp  Ala Glu Asp Met Ala  Asp Tyr Gly Glu Gly  Trp Asn Ala 

    2060                 2065                 2070             





Thr Thr  Leu Ser Glu Trp Gln  Tyr Gln Ser Gln Asp  Gln Arg Gln 

    2075                 2080                 2085             





Gly Tyr  Pro Ile Trp Gly Lys  Leu Thr Val Tyr Arg  Gly Gly Gly 

    2090                 2095                 2100             





Tyr Val  Val Pro Leu Gly Thr  Asp Arg Gln Ser Thr  Ser Arg Ile 

    2105                 2110                 2115             





Leu Arg  Tyr Leu Phe Asp Asn  Thr Trp Leu Asp Ala  Leu Thr Arg 

    2120                 2125                 2130             





Ala Val  Phe Val Glu Ser Thr  Val Tyr Asn Ala Asn  Val Asn Leu 

    2135                 2140                 2145             





Phe Cys  Ile Val Thr Leu Thr  Leu Glu Thr Ser Ala  Leu Gly Thr 

    2150                 2155                 2160             





Phe Phe  Thr His Ala Ala Leu  Gln Ser Leu Arg Leu  Tyr Pro Phe 

    2165                 2170                 2175             





Thr Asp  Gly Trp His Pro Phe  Val Val Ala Ala Glu  Leu Ile Tyr 

    2180                 2185                 2190             





Phe Leu  Phe Leu Leu Tyr Tyr  Met Val Val Gln Gly  Lys Arg Met 

    2195                 2200                 2205             





Ser Lys  Glu Thr Trp Gly Tyr  Phe Cys Ser Lys Trp  Asn Leu Leu 

    2210                 2215                 2220             





Glu Leu  Ala Ile Ile Leu Ala  Ser Trp Ser Ala Leu  Ala Val Phe 

    2225                 2230                 2235             





Val Lys  Arg Ala Val Leu Ala  Glu Arg Asp Leu Gln  Arg Cys Arg 

    2240                 2245                 2250             





Asn His  Arg Glu Glu Gly Ile  Ser Phe Ser Glu Thr  Ala Ala Ala 

    2255                 2260                 2265             





Asp Ala  Ala Leu Gly Tyr Ile  Ile Ala Phe Leu Val  Leu Leu Ser 

    2270                 2275                 2280             





Thr Val  Lys Leu Trp His Leu  Leu Arg Leu Asn Pro  Lys Met Asn 

    2285                 2290                 2295             





Met Ile  Thr Ala Ala Leu Arg  Arg Ala Trp Gly Asp  Ile Ser Gly 

    2300                 2305                 2310             





Phe Met  Ile Val Ile Leu Thr  Met Leu Leu Ala Tyr  Ser Ile Ala 

    2315                 2320                 2325             





Ser Asn  Leu Ile Phe Gly Trp  Lys Leu Arg Ser Tyr  Lys Thr Leu 

    2330                 2335                 2340             





Phe Asp  Ala Ala Glu Thr Met  Val Ser Leu Gln Leu  Gly Ile Phe 

    2345                 2350                 2355             





Asn Tyr  Glu Glu Val Leu Asp  Tyr Ser Pro Val Leu  Gly Ser Phe 

    2360                 2365                 2370             





Leu Ile  Gly Ser Cys Ile Val  Phe Met Thr Phe Val  Val Leu Asn 

    2375                 2380                 2385             





Leu Phe  Ile Ser Val Ile Leu  Val Ala Phe Ser Glu  Glu Gln Lys 

    2390                 2395                 2400             





Tyr Tyr  Gln Leu Ser Glu Glu  Gly Glu Ile Val Asp  Leu Leu Leu 

    2405                 2410                 2415             





Met Lys  Ile Leu Ser Phe Leu  Gly Ile Lys Ser Lys  Arg Glu Glu 

    2420                 2425                 2430             





Pro Gly  Ser Ser Arg Glu Gln  Pro Gly Ser Leu Ser  Gln Thr Arg 

    2435                 2440                 2445             





His Ser  Arg Pro Ala Gln Ala  Leu Pro Lys Asp 

    2450                 2455                 





<210>  238

<211>  2995

<212>  DNA

<213>  Homo sapiens



<400>  238

taggcttcct ccctccctgt cgccgccagc ctctcgctct ccccgtcttc cgcccgcact       60



ctctgggcag ggctgcggcc aggacccgcc cccgcgtccc gcccgaccct ccgccagggg      120



tcacttcccc tgtccaggtt tcagcttcca catgtgtcaa gcggctggct cagcccagag      180



tccctgtctc ccgcccgccg gcccgagccg ccgcccctcc cccgcctccc gtgcgcccgg      240



gacaatcctc gccttgtctg tggcgccggc atctggagct ttctgtagcc tccggatacg      300



cctttttttc agggcgtagc cccagccaag ctgctccccg cggcggccgc acagcagccc      360



gagcgccccc tttccagagc tcccctccgg agctgggatc caggcgcgta gcggagatcc      420



caggatcctg ggtgctgtct gggcccgctc cccaccatga cctcctcggg gcctggaccc      480



cggttcctgc tgctgctgcc gctgctgctg ccccctgcgg cctcagcctc cgaccggccc      540



cggggccgag acccggtcaa cccagagaag ctgctggtga tcactgtggc cacagctgaa      600



accgaggggt acctgcgttt cctgcgctct gcggagttct tcaactacac tgtgcggacc      660



ctgggcctgg gagaggagtg gcgagggggt gatgtggctc gaacagttgg tggaggacag      720



aaggtccggt ggttaaagaa ggaaatggag aaatacgctg accgggagga tatgatcatc      780



atgtttgtgg atagctacga cgtgattctg gccggcagcc ccacagagct gctgaagaag      840



ttcgtccaga gtggcagccg cctgctcttc tctgcagaga gcttctgctg gcccgagtgg      900



gggctggcgg agcagtaccc tgaggtgggc acggggaagc gcttcctcaa ttctggtgga      960



ttcatcggtt ttgccaccac catccaccaa atcgtgcgcc agtggaagta caaggatgat     1020



gacgacgacc agctgttcta cacacggctc tacctggacc caggactgag ggagaaactc     1080



agccttaatc tggatcataa gtctcggatc tttcagaacc tcaacggggc tttagatgaa     1140



gtggttttaa agtttgatcg gaaccgtgtg cgtatccgga acgtggccta cgacacgctc     1200



cccattgtgg tccatggaaa cggtcccact aagctgcagc tcaactacct gggaaactac     1260



gtccccaatg gctggactcc tgagggaggc tgtggcttct gcaaccagga ccggaggaca     1320



ctcccggggg ggcagcctcc cccccgggtg tttctggccg tgtttgtgga acagcctact     1380



ccgtttctgc cccgcttcct gcagcggctg ctactcctgg actatccccc cgacagggtc     1440



acccttttcc tgcacaacaa cgaggtcttc catgaacccc acatcgctga ctcctggccg     1500



cagctccagg accacttctc agctgtgaag ctcgtggggc cggaggaggc tctgagccca     1560



ggcgaggcca gggacatggc catggacctg tgtcggcagg accccgagtg tgagttctac     1620



ttcagcctgg acgccgacgc tgtcctcacc aacctgcaga ccctgcgtat cctcattgag     1680



gagaacagga aggtgatcgc ccccatgctg tcccgccacg gcaagctgtg gtccaacttc     1740



tggggcgccc tgagccccga tgagtactac gcccgctccg aggactacgt ggagctggtg     1800



cagcggaagc gagtgggtgt gtggaatgta ccatacatct cccaggccta tgtgatccgg     1860



ggtgataccc tgcggatgga gctgccccag agggatgtgt tctcgggcag tgacacagac     1920



ccggacatgg ccttctgtaa gagctttcga gacaagggca tcttcctcca tctgagcaat     1980



cagcatgaat ttggccggct cctggccact tccagatacg acacggagca cctgcacccc     2040



gacctctggc agatcttcga caaccccgtc gactggaagg agcagtacat ccacgagaac     2100



tacagccggg ccctggaagg ggaaggaatc gtggagcagc catgcccgga cgtgtactgg     2160



ttcccactgc tgtcagaaca aatgtgtgat gagctggtgg cagagatgga gcactacggc     2220



cagtggtcag gcggccggca tgaggattca aggctggctg gaggctacga gaatgtgccc     2280



accgtggaca tccacatgaa gcaggtgggg tacgaggacc agtggctgca gctgctgcgg     2340



acgtatgtgg gccccatgac cgagagcctg tttcccggtt accacaccaa ggcgcgggcg     2400



gtgatgaact ttgtggttcg ctaccggcca gacgagcagc cgtctctgcg gccacaccac     2460



gactcatcca ccttcaccct caacgttgcc ctcaaccaca agggcctgga ctatgaggga     2520



ggtggctgcc gcttcctgcg ctacgactgt gtgatctcct ccccgaggaa gggctgggca     2580



ctcctgcacc ccggccgcct cacccactac cacgaggggc tgccaacgac ctggggcaca     2640



cgctacatca tggtgtcctt tgtcgacccc tgacactcaa ccactctgcc aaacctgccc     2700



tgccattgtg cctttttagg gggcctggcc cccgtcctgg gagttggggg atgggtctct     2760



ctgtctcccc acttcctgag ttcatgttcc gcgtgcctga actgaatatg tcaccttgct     2820



cccaagacac ggccctctca ggaagctccc ggagtccccg cctctctcct ccgcccacag     2880



gggttcgtgg gcacagggct tctggggact ccccgcgtga taaattatta atgttccgca     2940



gtctcactct gaataaagga cagtttgtaa gtcttgaaaa aaaaaaaaaa aaaaa          2995





<210>  239

<211>  738

<212>  PRT

<213>  Homo sapiens



<400>  239



Met Thr Ser Ser Gly Pro Gly Pro Arg Phe Leu Leu Leu Leu Pro Leu 

1               5                   10                  15      





Leu Leu Pro Pro Ala Ala Ser Ala Ser Asp Arg Pro Arg Gly Arg Asp 

            20                  25                  30          





Pro Val Asn Pro Glu Lys Leu Leu Val Ile Thr Val Ala Thr Ala Glu 

        35                  40                  45              





Thr Glu Gly Tyr Leu Arg Phe Leu Arg Ser Ala Glu Phe Phe Asn Tyr 

    50                  55                  60                  





Thr Val Arg Thr Leu Gly Leu Gly Glu Glu Trp Arg Gly Gly Asp Val 

65                  70                  75                  80  





Ala Arg Thr Val Gly Gly Gly Gln Lys Val Arg Trp Leu Lys Lys Glu 

                85                  90                  95      





Met Glu Lys Tyr Ala Asp Arg Glu Asp Met Ile Ile Met Phe Val Asp 

            100                 105                 110         





Ser Tyr Asp Val Ile Leu Ala Gly Ser Pro Thr Glu Leu Leu Lys Lys 

        115                 120                 125             





Phe Val Gln Ser Gly Ser Arg Leu Leu Phe Ser Ala Glu Ser Phe Cys 

    130                 135                 140                 





Trp Pro Glu Trp Gly Leu Ala Glu Gln Tyr Pro Glu Val Gly Thr Gly 

145                 150                 155                 160 





Lys Arg Phe Leu Asn Ser Gly Gly Phe Ile Gly Phe Ala Thr Thr Ile 

                165                 170                 175     





His Gln Ile Val Arg Gln Trp Lys Tyr Lys Asp Asp Asp Asp Asp Gln 

            180                 185                 190         





Leu Phe Tyr Thr Arg Leu Tyr Leu Asp Pro Gly Leu Arg Glu Lys Leu 

        195                 200                 205             





Ser Leu Asn Leu Asp His Lys Ser Arg Ile Phe Gln Asn Leu Asn Gly 

    210                 215                 220                 





Ala Leu Asp Glu Val Val Leu Lys Phe Asp Arg Asn Arg Val Arg Ile 

225                 230                 235                 240 





Arg Asn Val Ala Tyr Asp Thr Leu Pro Ile Val Val His Gly Asn Gly 

                245                 250                 255     





Pro Thr Lys Leu Gln Leu Asn Tyr Leu Gly Asn Tyr Val Pro Asn Gly 

            260                 265                 270         





Trp Thr Pro Glu Gly Gly Cys Gly Phe Cys Asn Gln Asp Arg Arg Thr 

        275                 280                 285             





Leu Pro Gly Gly Gln Pro Pro Pro Arg Val Phe Leu Ala Val Phe Val 

    290                 295                 300                 





Glu Gln Pro Thr Pro Phe Leu Pro Arg Phe Leu Gln Arg Leu Leu Leu 

305                 310                 315                 320 





Leu Asp Tyr Pro Pro Asp Arg Val Thr Leu Phe Leu His Asn Asn Glu 

                325                 330                 335     





Val Phe His Glu Pro His Ile Ala Asp Ser Trp Pro Gln Leu Gln Asp 

            340                 345                 350         





His Phe Ser Ala Val Lys Leu Val Gly Pro Glu Glu Ala Leu Ser Pro 

        355                 360                 365             





Gly Glu Ala Arg Asp Met Ala Met Asp Leu Cys Arg Gln Asp Pro Glu 

    370                 375                 380                 





Cys Glu Phe Tyr Phe Ser Leu Asp Ala Asp Ala Val Leu Thr Asn Leu 

385                 390                 395                 400 





Gln Thr Leu Arg Ile Leu Ile Glu Glu Asn Arg Lys Val Ile Ala Pro 

                405                 410                 415     





Met Leu Ser Arg His Gly Lys Leu Trp Ser Asn Phe Trp Gly Ala Leu 

            420                 425                 430         





Ser Pro Asp Glu Tyr Tyr Ala Arg Ser Glu Asp Tyr Val Glu Leu Val 

        435                 440                 445             





Gln Arg Lys Arg Val Gly Val Trp Asn Val Pro Tyr Ile Ser Gln Ala 

    450                 455                 460                 





Tyr Val Ile Arg Gly Asp Thr Leu Arg Met Glu Leu Pro Gln Arg Asp 

465                 470                 475                 480 





Val Phe Ser Gly Ser Asp Thr Asp Pro Asp Met Ala Phe Cys Lys Ser 

                485                 490                 495     





Phe Arg Asp Lys Gly Ile Phe Leu His Leu Ser Asn Gln His Glu Phe 

            500                 505                 510         





Gly Arg Leu Leu Ala Thr Ser Arg Tyr Asp Thr Glu His Leu His Pro 

        515                 520                 525             





Asp Leu Trp Gln Ile Phe Asp Asn Pro Val Asp Trp Lys Glu Gln Tyr 

    530                 535                 540                 





Ile His Glu Asn Tyr Ser Arg Ala Leu Glu Gly Glu Gly Ile Val Glu 

545                 550                 555                 560 





Gln Pro Cys Pro Asp Val Tyr Trp Phe Pro Leu Leu Ser Glu Gln Met 

                565                 570                 575     





Cys Asp Glu Leu Val Ala Glu Met Glu His Tyr Gly Gln Trp Ser Gly 

            580                 585                 590         





Gly Arg His Glu Asp Ser Arg Leu Ala Gly Gly Tyr Glu Asn Val Pro 

        595                 600                 605             





Thr Val Asp Ile His Met Lys Gln Val Gly Tyr Glu Asp Gln Trp Leu 

    610                 615                 620                 





Gln Leu Leu Arg Thr Tyr Val Gly Pro Met Thr Glu Ser Leu Phe Pro 

625                 630                 635                 640 





Gly Tyr His Thr Lys Ala Arg Ala Val Met Asn Phe Val Val Arg Tyr 

                645                 650                 655     





Arg Pro Asp Glu Gln Pro Ser Leu Arg Pro His His Asp Ser Ser Thr 

            660                 665                 670         





Phe Thr Leu Asn Val Ala Leu Asn His Lys Gly Leu Asp Tyr Glu Gly 

        675                 680                 685             





Gly Gly Cys Arg Phe Leu Arg Tyr Asp Cys Val Ile Ser Ser Pro Arg 

    690                 695                 700                 





Lys Gly Trp Ala Leu Leu His Pro Gly Arg Leu Thr His Tyr His Glu 

705                 710                 715                 720 





Gly Leu Pro Thr Thr Trp Gly Thr Arg Tyr Ile Met Val Ser Phe Val 

                725                 730                 735     





Asp Pro 

        





<210>  240

<211>  2177

<212>  DNA

<213>  Homo sapiens



<400>  240

ggaagaaggc ccctcggcct cagcagagcg ctatcctcca ctggttaccc gggttccccg       60



gcttgctacc gggctgctcc gtgcatcttt ccccccaggc gtcaggaact gcgccctcat      120



ggcggaggtg aaggtgaagg tgcagccgcc tgacgcggat ccggtcgaaa tagaaaacag      180



gattatagaa ttatgtcacc agttccctca tggaatcaca gaccaagtaa ttcagaatga      240



aatgcctcat atagaagccc agcagcgggc agtagccatc aataggttgt tgtctatggg      300



tcagttggat ctcttaagga gcaatacggg ccttttatat agaataaagg actctcagaa      360



tgctggtaaa atgaagggat ccgataacca agaaaaacta gtatatcaaa tcatagagga      420



tgcaggaaat aaaggaatat ggagcagaga tatccgctat aaaagtaatt tgccattaac      480



agaaatcaac aaaattctga agaatctgga aagtaaaaag cttatcaaag ctgttaagtc      540



tgtagcagcc tcaaaaaaga aggtgtatat gctctataac ctgcagccag accggtctgt      600



gactggtgga gcctggtaca gtgaccagga ttttgaatct gaatttgtag aggtgcttaa      660



ccaacagtgt tttaaattcc tacagtccaa ggcagaaaca gcacgagaaa gcaaacagaa      720



cccaatgata caaagaaata gttcatttgc ctcatcacat gaagtgtgga aatatatctg      780



cgaattggga atcagtaagg tagagttatc catggaagac attgaaacca tcctgaatac      840



actcatttat gatggaaaag tggagatgac gattattgct gcaaaagaag gcacagttgg      900



cagtgtagat ggacacatga aactgtacag ggcagtcaat ccaatcatcc ctcccacagg      960



tttggtccgg gcaccctgtg gactctgccc ggtttttgat gactgccacg aaggtggtga     1020



gatttcacca tctaactgta tttacatgac agagtggctc gaattttaat agagagctat     1080



gaactttatt gacattttgc aaatgaagtt acttagggag cagataattt aattcatgat     1140



ggaacacgaa atctccttga aagcaaactt cacaataatg gacgtagact tgctgctatg     1200



aaaacatatt ttttttattt atgaagacta aatttatatt ggtaaaatag ccagtagaat     1260



atgaaagaaa taaggttagt agtgaaattc attcttcaat aaataaaaca ctttgaaact     1320



ccggaggacc acatctttca agacttctga tgggtcaagg aaaaagatgc caacataccc     1380



gtatttacca agtactatga taatggctag agtataaaaa tgttcttttt aaagttattt     1440



attaagttct tcattggaag ttttttttta tatctggttc actaccacca ttttctgttt     1500



cctactttct cagtggtttc attgaaaaga aattagaagg ggttaaaggc aggaatagca     1560



aagagtgcaa acttggggta tgactggggg agagtggaac atgccttttc cgcacaatat     1620



taattccttt ttgtatcaga aatgttcttt taggagatta tgctaccata cttacttcaa     1680



acccaatgac tactgtcaag gacatatttt cagtacataa atactatcat tttcattcta     1740



aagaatattt tcactgttcc ttctttctta aagtcttatg tttcactctt taactcaaat     1800



gtattctttg ttagaattta ccctagattc ttatttaatg tctgcagtag actgaatgtt     1860



tgtgtgcccc cagaattcta atgttgaaat ctcatttcca atgtgatggt atttggaggt     1920



ggggcttttg gtaagtgata ggtcaggaga gtaacagcgc tcatgaatgg gattagtgcc     1980



cttatataaa gagacccaga gagctccatc accccttctg ccatgtgaaa gggagaagac     2040



aaacatccac gaaccaggaa gtgggtcctc accagaaaac aaatctgtaa gcaccttgat     2100



cttggacttc ccagcctcca gaattgtgag aaataaattt ctgttgttga taaaaaaaaa     2160



aaaaaaaaaa aaaaaaa                                                    2177





<210>  241

<211>  316

<212>  PRT

<213>  Homo sapiens



<400>  241



Met Ala Glu Val Lys Val Lys Val Gln Pro Pro Asp Ala Asp Pro Val 

1               5                   10                  15      





Glu Ile Glu Asn Arg Ile Ile Glu Leu Cys His Gln Phe Pro His Gly 

            20                  25                  30          





Ile Thr Asp Gln Val Ile Gln Asn Glu Met Pro His Ile Glu Ala Gln 

        35                  40                  45              





Gln Arg Ala Val Ala Ile Asn Arg Leu Leu Ser Met Gly Gln Leu Asp 

    50                  55                  60                  





Leu Leu Arg Ser Asn Thr Gly Leu Leu Tyr Arg Ile Lys Asp Ser Gln 

65                  70                  75                  80  





Asn Ala Gly Lys Met Lys Gly Ser Asp Asn Gln Glu Lys Leu Val Tyr 

                85                  90                  95      





Gln Ile Ile Glu Asp Ala Gly Asn Lys Gly Ile Trp Ser Arg Asp Ile 

            100                 105                 110         





Arg Tyr Lys Ser Asn Leu Pro Leu Thr Glu Ile Asn Lys Ile Leu Lys 

        115                 120                 125             





Asn Leu Glu Ser Lys Lys Leu Ile Lys Ala Val Lys Ser Val Ala Ala 

    130                 135                 140                 





Ser Lys Lys Lys Val Tyr Met Leu Tyr Asn Leu Gln Pro Asp Arg Ser 

145                 150                 155                 160 





Val Thr Gly Gly Ala Trp Tyr Ser Asp Gln Asp Phe Glu Ser Glu Phe 

                165                 170                 175     





Val Glu Val Leu Asn Gln Gln Cys Phe Lys Phe Leu Gln Ser Lys Ala 

            180                 185                 190         





Glu Thr Ala Arg Glu Ser Lys Gln Asn Pro Met Ile Gln Arg Asn Ser 

        195                 200                 205             





Ser Phe Ala Ser Ser His Glu Val Trp Lys Tyr Ile Cys Glu Leu Gly 

    210                 215                 220                 





Ile Ser Lys Val Glu Leu Ser Met Glu Asp Ile Glu Thr Ile Leu Asn 

225                 230                 235                 240 





Thr Leu Ile Tyr Asp Gly Lys Val Glu Met Thr Ile Ile Ala Ala Lys 

                245                 250                 255     





Glu Gly Thr Val Gly Ser Val Asp Gly His Met Lys Leu Tyr Arg Ala 

            260                 265                 270         





Val Asn Pro Ile Ile Pro Pro Thr Gly Leu Val Arg Ala Pro Cys Gly 

        275                 280                 285             





Leu Cys Pro Val Phe Asp Asp Cys His Glu Gly Gly Glu Ile Ser Pro 

    290                 295                 300                 





Ser Asn Cys Ile Tyr Met Thr Glu Trp Leu Glu Phe 

305                 310                 315     





<210>  242

<211>  1262

<212>  DNA

<213>  Homo sapiens



<400>  242

ctcagagcct tcctgatgta tatatgcagg tagtgagaat tgaatcggcc ctttgagaca       60



gtaatataat aaaactctga tttggggagc agcggttctc cttatttttc tactctcttg      120



tgggaatgag ttgccaagct tttacttcgg ctgatacctt tatacctctg aattctgacg      180



cctctgcaac tctgcctctg ataatgcatc acagtgctgc cgagtgtcta ccagtctcca      240



accatgccac caatgtgatg tctacagcaa caggacttca ttattctgtt ccttcctgtc      300



attatggaaa ccagccatca acctatggag tgatggcagg tagtttaacc ccttgtcttt      360



ataaatttcc tgaccacacc ttgagtcatg gatttcctcc tatacaccag cctcttctgg      420



cagaggaccc cacagctgct gatttcaagc aggaactcag gcggaaaagt aaattggtgg      480



aagagccaat agacatggat tctccagaaa tcagagaact tgaaaagttt gccaatgaat      540



ttaaagtgag acgaattaaa ttaggataca cccagacaaa tgttggggag gccctggcag      600



ctgtgcatgg ctctgaattc agtcaaacaa caatctgccg atttgaaaat ctgcagctca      660



gctttaaaaa tgcatgcaaa ctgaaagcaa tattatccaa atggctggag gaagctgagc      720



aagtaggagc tttgtacaat gaaaaagtgg gagcaaatga aaggaaaaga aaacgaagaa      780



caactataag cattgctgct aaagatgctc tggagagaca ctttggagaa cagaataaac      840



cttcttctca agagatcatg aggatggctg aagaactgaa tctggagaaa gaagtagtaa      900



gagtttggtt ttgcaaccgg aggcagagag aaaaacgggt gaaaacaagt ctgaatcaga      960



gtttattttc tatttctaag gaacatcttg agtgcagata agatttttct attgtataat     1020



agcctttttc tcccgtttca ttcctttctc ttcctcaaca aaaacagaaa ttacttggtt     1080



gacttaaaat cattttatat caatagcttt tacagaagct ttacttttcc actttttttt     1140



aaaaaaaaga aaccaacaat ttaaattata ttgatgttat ttacttaaaa taattattct     1200



cagaagccac attgtctatt ttaagccaaa tatattaaca gtaataaaat gatctctctg     1260



tc                                                                    1262





<210>  243

<211>  291

<212>  PRT

<213>  Homo sapiens



<400>  243



Met Ser Cys Gln Ala Phe Thr Ser Ala Asp Thr Phe Ile Pro Leu Asn 

1               5                   10                  15      





Ser Asp Ala Ser Ala Thr Leu Pro Leu Ile Met His His Ser Ala Ala 

            20                  25                  30          





Glu Cys Leu Pro Val Ser Asn His Ala Thr Asn Val Met Ser Thr Ala 

        35                  40                  45              





Thr Gly Leu His Tyr Ser Val Pro Ser Cys His Tyr Gly Asn Gln Pro 

    50                  55                  60                  





Ser Thr Tyr Gly Val Met Ala Gly Ser Leu Thr Pro Cys Leu Tyr Lys 

65                  70                  75                  80  





Phe Pro Asp His Thr Leu Ser His Gly Phe Pro Pro Ile His Gln Pro 

                85                  90                  95      





Leu Leu Ala Glu Asp Pro Thr Ala Ala Asp Phe Lys Gln Glu Leu Arg 

            100                 105                 110         





Arg Lys Ser Lys Leu Val Glu Glu Pro Ile Asp Met Asp Ser Pro Glu 

        115                 120                 125             





Ile Arg Glu Leu Glu Lys Phe Ala Asn Glu Phe Lys Val Arg Arg Ile 

    130                 135                 140                 





Lys Leu Gly Tyr Thr Gln Thr Asn Val Gly Glu Ala Leu Ala Ala Val 

145                 150                 155                 160 





His Gly Ser Glu Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Asn Leu 

                165                 170                 175     





Gln Leu Ser Phe Lys Asn Ala Cys Lys Leu Lys Ala Ile Leu Ser Lys 

            180                 185                 190         





Trp Leu Glu Glu Ala Glu Gln Val Gly Ala Leu Tyr Asn Glu Lys Val 

        195                 200                 205             





Gly Ala Asn Glu Arg Lys Arg Lys Arg Arg Thr Thr Ile Ser Ile Ala 

    210                 215                 220                 





Ala Lys Asp Ala Leu Glu Arg His Phe Gly Glu Gln Asn Lys Pro Ser 

225                 230                 235                 240 





Ser Gln Glu Ile Met Arg Met Ala Glu Glu Leu Asn Leu Glu Lys Glu 

                245                 250                 255     





Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Arg Glu Lys Arg Val 

            260                 265                 270         





Lys Thr Ser Leu Asn Gln Ser Leu Phe Ser Ile Ser Lys Glu His Leu 

        275                 280                 285             





Glu Cys Arg 

    290     





<210>  244

<211>  1340

<212>  DNA

<213>  Homo sapiens



<400>  244

ctcagagcct tcctgatgta tatatgcagg tagtgagaat tgaatcggcc ctttgagaca       60



gtaatataat aaaactctga tttggggagc agcggttctc cttatttttc tactctcttg      120



tgggaatgag ttgccaagct tttacttcgg ctgatacctt tatacctctg aattctgacg      180



cctctgcaac tctgcctctg ataatgcatc acagtgctgc cgagtgtcta ccagtctcca      240



accatgccac caatgtgatg tctacagtcc catctatttt gtctttgatc caaactccta      300



aatgtttgtg cacacatttc tcggtgacaa cgttgggaaa cacagcaaca ggacttcatt      360



attctgttcc ttcctgtcat tatggaaacc agccatcaac ctatggagtg atggcaggta      420



gtttaacccc ttgtctttat aaatttcctg accacacctt gagtcatgga tttcctccta      480



tacaccagcc tcttctggca gaggacccca cagctgctga tttcaagcag gaactcaggc      540



ggaaaagtaa attggtggaa gagccaatag acatggattc tccagaaatc agagaacttg      600



aaaagtttgc caatgaattt aaagtgagac gaattaaatt aggatacacc cagacaaatg      660



ttggggaggc cctggcagct gtgcatggct ctgaattcag tcaaacaaca atctgccgat      720



ttgaaaatct gcagctcagc tttaaaaatg catgcaaact gaaagcaata ttatccaaat      780



ggctggagga agctgagcaa gtaggagctt tgtacaatga aaaagtggga gcaaatgaaa      840



ggaaaagaaa acgaagaaca actataagca ttgctgctaa agatgctctg gagagacact      900



ttggagaaca gaataaacct tcttctcaag agatcatgag gatggctgaa gaactgaatc      960



tggagaaaga agtagtaaga gtttggtttt gcaaccggag gcagagagaa aaacgggtga     1020



aaacaagtct gaatcagagt ttattttcta tttctaagga acatcttgag tgcagataag     1080



atttttctat tgtataatag cctttttctc ccgtttcatt cctttctctt cctcaacaaa     1140



aacagaaatt acttggttga cttaaaatca ttttatatca atagctttta cagaagcttt     1200



acttttccac ttttttttaa aaaaaagaaa ccaacaattt aaattatatt gatgttattt     1260



acttaaaata attattctca gaagccacat tgtctatttt aagccaaata tattaacagt     1320



aataaaatga tctctctgtc                                                 1340





<210>  245

<211>  317

<212>  PRT

<213>  Homo sapiens



<400>  245



Met Ser Cys Gln Ala Phe Thr Ser Ala Asp Thr Phe Ile Pro Leu Asn 

1               5                   10                  15      





Ser Asp Ala Ser Ala Thr Leu Pro Leu Ile Met His His Ser Ala Ala 

            20                  25                  30          





Glu Cys Leu Pro Val Ser Asn His Ala Thr Asn Val Met Ser Thr Val 

        35                  40                  45              





Pro Ser Ile Leu Ser Leu Ile Gln Thr Pro Lys Cys Leu Cys Thr His 

    50                  55                  60                  





Phe Ser Val Thr Thr Leu Gly Asn Thr Ala Thr Gly Leu His Tyr Ser 

65                  70                  75                  80  





Val Pro Ser Cys His Tyr Gly Asn Gln Pro Ser Thr Tyr Gly Val Met 

                85                  90                  95      





Ala Gly Ser Leu Thr Pro Cys Leu Tyr Lys Phe Pro Asp His Thr Leu 

            100                 105                 110         





Ser His Gly Phe Pro Pro Ile His Gln Pro Leu Leu Ala Glu Asp Pro 

        115                 120                 125             





Thr Ala Ala Asp Phe Lys Gln Glu Leu Arg Arg Lys Ser Lys Leu Val 

    130                 135                 140                 





Glu Glu Pro Ile Asp Met Asp Ser Pro Glu Ile Arg Glu Leu Glu Lys 

145                 150                 155                 160 





Phe Ala Asn Glu Phe Lys Val Arg Arg Ile Lys Leu Gly Tyr Thr Gln 

                165                 170                 175     





Thr Asn Val Gly Glu Ala Leu Ala Ala Val His Gly Ser Glu Phe Ser 

            180                 185                 190         





Gln Thr Thr Ile Cys Arg Phe Glu Asn Leu Gln Leu Ser Phe Lys Asn 

        195                 200                 205             





Ala Cys Lys Leu Lys Ala Ile Leu Ser Lys Trp Leu Glu Glu Ala Glu 

    210                 215                 220                 





Gln Val Gly Ala Leu Tyr Asn Glu Lys Val Gly Ala Asn Glu Arg Lys 

225                 230                 235                 240 





Arg Lys Arg Arg Thr Thr Ile Ser Ile Ala Ala Lys Asp Ala Leu Glu 

                245                 250                 255     





Arg His Phe Gly Glu Gln Asn Lys Pro Ser Ser Gln Glu Ile Met Arg 

            260                 265                 270         





Met Ala Glu Glu Leu Asn Leu Glu Lys Glu Val Val Arg Val Trp Phe 

        275                 280                 285             





Cys Asn Arg Arg Gln Arg Glu Lys Arg Val Lys Thr Ser Leu Asn Gln 

    290                 295                 300                 





Ser Leu Phe Ser Ile Ser Lys Glu His Leu Glu Cys Arg 

305                 310                 315         





<210>  246

<211>  1045

<212>  DNA

<213>  Homo sapiens



<400>  246

actatccggc gccgagccgg aggggggaaa cggcgcccgc cgcccgcccg gagcccgcga       60



gcaaccccag tcccccccac ccgcgcgtgg cggcgccggc tccctagcca ccgcggcccc      120



accctcttcc ggcctcagct gtccgggctg ctttcgcctc cgcctgtgga tgctgcgcct      180



ctccgaacgc aacatgaagg tgctccttgc cgccgccctc atcgcggggt ccgtcttctt      240



cctgctgctg ccgggacctt ctgcggccga tgagaagaag aaggggccca aagtcaccgt      300



caaggtgtat tttgacctac gaattggaga tgaagatgta ggccgggtga tctttggtct      360



cttcggaaag actgttccaa aaacagtgga taattttgtg gccttagcta caggagagaa      420



aggatttggc tacaaaaaca gcaaattcca tcgtgtaatc aaggacttca tgatccaggg      480



cggagacttc accaggggag atggcacagg aggaaagagc atctacggtg agcgcttccc      540



cgatgagaac ttcaaactga agcactacgg gcctggctgg gtgagcatgg ccaacgcagg      600



caaagacacc aacggctccc agttcttcat cacgacagtc aagacagcct ggctagatgg      660



caagcatgtg gtgtttggca aagttctaga gggcatggag gtggtgcgga aggtggagag      720



caccaagaca gacagccggg ataaacccct gaaggatgtg atcatcgcag actgcggcaa      780



gatcgaggtg gagaagccct ttgccatcgc caaggagtag ggcacaggga catctttctt      840



tgagtgaccg tctgtgcagg ccctgtagtc cgccacaggg ctctgagctg cactggcccc      900



ggtgctggca tctggtggag cggacccact cccctcacat tccacaggcc catggactca      960



cttttgtaac aaactcctac caacactgac caataaaaaa aaatgtgggt tttttttttt     1020



ttaatataaa aaaaaaaaaa aaaaa                                           1045





<210>  247

<211>  216

<212>  PRT

<213>  Homo sapiens



<400>  247



Met Leu Arg Leu Ser Glu Arg Asn Met Lys Val Leu Leu Ala Ala Ala 

1               5                   10                  15      





Leu Ile Ala Gly Ser Val Phe Phe Leu Leu Leu Pro Gly Pro Ser Ala 

            20                  25                  30          





Ala Asp Glu Lys Lys Lys Gly Pro Lys Val Thr Val Lys Val Tyr Phe 

        35                  40                  45              





Asp Leu Arg Ile Gly Asp Glu Asp Val Gly Arg Val Ile Phe Gly Leu 

    50                  55                  60                  





Phe Gly Lys Thr Val Pro Lys Thr Val Asp Asn Phe Val Ala Leu Ala 

65                  70                  75                  80  





Thr Gly Glu Lys Gly Phe Gly Tyr Lys Asn Ser Lys Phe His Arg Val 

                85                  90                  95      





Ile Lys Asp Phe Met Ile Gln Gly Gly Asp Phe Thr Arg Gly Asp Gly 

            100                 105                 110         





Thr Gly Gly Lys Ser Ile Tyr Gly Glu Arg Phe Pro Asp Glu Asn Phe 

        115                 120                 125             





Lys Leu Lys His Tyr Gly Pro Gly Trp Val Ser Met Ala Asn Ala Gly 

    130                 135                 140                 





Lys Asp Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Val Lys Thr Ala 

145                 150                 155                 160 





Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Leu Glu Gly Met 

                165                 170                 175     





Glu Val Val Arg Lys Val Glu Ser Thr Lys Thr Asp Ser Arg Asp Lys 

            180                 185                 190         





Pro Leu Lys Asp Val Ile Ile Ala Asp Cys Gly Lys Ile Glu Val Glu 

        195                 200                 205             





Lys Pro Phe Ala Ile Ala Lys Glu 

    210                 215     





<210>  248

<211>  2385

<212>  DNA

<213>  Homo sapiens



<400>  248

gcgccatttt gaaagtggag tcgcctgccc ctgccgctgc cgccgccgcc gtcgctgtcg       60



tagtcgccgc cgccgctgcc ggagaaagag cacgagcggg gaagccccag agtgaaatct      120



agcatcctgc cggctggtct gcccgcccct ccttcctttt ccccccggcc cccgtcccct      180



ccccccgcag gtgccatccg ccgccatccg ccctctctac ccccccatcc ccaggtgagg      240



ggggtgagtt caggaagcgg agaccccgag gaacccagca gggtcaccat ttgcagcgca      300



acatggcagg agctggagga gggaatgata ttcagtggtg tttttctcag gtgaaaggag      360



cagtagatga tgatgtagca gaagcagata taatttctac agtagaattt aatcattctg      420



gagaattact agcaacagga gataaaggtg gtagagttgt catctttcaa caggagcagg      480



agaacaaaat ccagtctcat agcagaggag aatataatgt ttacagcacc ttccagagcc      540



atgaaccaga gtttgactac ttgaaaagtt tagaaataga agaaaagatc aacaaaatta      600



ggtggttacc ccagaaaaat gctgctcagt ttttattgtc taccaatgat aaaacaataa      660



aattatggaa aatcagtgaa agggacaaaa gaccagaagg gtataacttg aaagaggagg      720



atggaaggta tagagatcct actacagtta ctacactacg agtgccagtc tttaggccta      780



tggatctaat ggttgaggcc agtccacgaa gaatatttgc caatgctcat acatatcaca      840



tcaactcaat ttctattaat agtgattatg aaacatattt atctgcagat gatttgcgga      900



ttaatctttg gcatctggaa attacagaca ggagttttaa cattgtggat atcaagcctg      960



ccaatatgga agagctaaca gaggtgatta cagcagcaga atttcatcca aacagctgta     1020



acacatttgt atacagcagc agtaaaggaa ctattcggct atgtgacatg agggcatctg     1080



ccctctgtga tagacattct aaattgtttg aagaacctga agatcccagt aacaggtcat     1140



ttttttccga aatcatctcc tctatttcgg atgtaaaatt cagccatagt ggtcgatata     1200



tgatgactag agactatttg tcagtcaaaa tttgggactt aaatatggaa aacaggcctg     1260



tggaaacata ccaggtgcat gaatacctca gaagtaaact ctgttcactg tatgaaaatg     1320



actgcatatt tgacaaattt gaatgttgtt ggaatggatc tgacagtgtt gtcatgactg     1380



gatcttacaa taatttcttc agaatgtttg acagaaacac aaagcgagac ataaccctag     1440



aagcatcgcg ggaaaacaat aagcctcgca cagttctgaa gcctcgcaaa gtctgtgcaa     1500



gtggcaagcg aaagaaagat gaaataagtg ttgacagcct agacttcaat aagaaaatcc     1560



ttcacacagc ctggcacccc aaggaaaata tcattgccgt agctactaca aacaatctgt     1620



atatatttca agacaaagtg aattagggtt ggcattccta gcagaagaac ccacttcctg     1680



cttagttgag atagttgaat ctagcattcg ttcctataaa agagagaggt ccattgtggc     1740



gcccctttcc agtgtttgac agtgtgccat tcgacaacac attgttatag ctacatggag     1800



aaagctctgt ggattcatca ctgtggtgtt ctccatgtct gctagccatt taggtaaggg     1860



tagggcactt ttaatttaaa tgacttcttg caccatcttg cctaatggac tagattggac     1920



tgtatcaaca ttgatttact ccacttttta tgccttccat tgtgatgacg tcaaacacag     1980



tgaaagcctt cagtcatgct atgggattta attgtgtatc ctcattactg tatcatttgt     2040



ggggtacacc ccttccccct ttttttaaat taaatacagc tcattcttac tgtggcttgt     2100



agcattcctc ctcttctggc ctcctggact gctccccttc atctcttacc cttgccccct     2160



ccacccggtc ttggtggtgg tatattaaaa aaagaaagaa tgaaagcaca caaaatgagt     2220



cagtttgggg tcagtggtat aaagggggta tatgttgcaa acaaatgttt tagtaacagt     2280



tggctgtaat cactcctcgc cgtgtctggc actgaaaata aggaaaaaaa acctactact     2340



gaataaaagt gacaaagaat ggaaaaaaaa aaaaaaaaaa aaaaa                     2385





<210>  249

<211>  447

<212>  PRT

<213>  Homo sapiens



<400>  249



Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 

1               5                   10                  15      





Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 

            20                  25                  30          





Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 

        35                  40                  45              





Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 

    50                  55                  60                  





Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 

65                  70                  75                  80  





Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 

                85                  90                  95      





Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 

            100                 105                 110         





Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 

        115                 120                 125             





Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 

    130                 135                 140                 





Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 

145                 150                 155                 160 





Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 

                165                 170                 175     





Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 

            180                 185                 190         





Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 

        195                 200                 205             





Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 

    210                 215                 220                 





Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 

225                 230                 235                 240 





Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 

                245                 250                 255     





Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 

            260                 265                 270         





Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 

        275                 280                 285             





Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 

    290                 295                 300                 





Tyr Leu Ser Val Lys Ile Trp Asp Leu Asn Met Glu Asn Arg Pro Val 

305                 310                 315                 320 





Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 

                325                 330                 335     





Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 

            340                 345                 350         





Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 

        355                 360                 365             





Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 

    370                 375                 380                 





Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 

385                 390                 395                 400 





Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 

                405                 410                 415     





Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 

            420                 425                 430         





Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 

        435                 440                 445         





<210>  250

<211>  2221

<212>  DNA

<213>  Homo sapiens



<400>  250

aattccctac cctcgacctg tcgatgcccc gcggccccgc ccgccctctt aagcctggct       60



cagccctcag ggcccgcccg aagtctaccg agcccgagtg gcctaccgag cccgagtggc      120



cccgcagcgt ccaggaggcg cccgctccgc ggtggcgctc ttggaggtgg tgtcggagag      180



ccgccgagcg tgcggtcccg ggatggctct accccggcca agtgaggccg tgcctcagga      240



caaggtgtgc tacccgccgg agagcagccc gcagaacctg gccgcgtact acacgccttt      300



cccgtcctat ggacactaca gaaacagcct ggccaccgtg gaggaagact tccaaccttt      360



ccggcagctg gaggccgcag cgtctgctgc ccccgccatg ccccccttcc ccttccggat      420



ggcgcctccc ttgctgagcc cgggtctggg cctacagagg gagcctctct acgatctgcc      480



ctggtacagc aagctgccac cgtggtaccc aattccccac gtccccaggg aagtgccgcc      540



cttcctgagc agcagccacg agtacgcggg tgccagcagt gaagatctgg gccaccaaat      600



cattggtggc gacaacgaga gtggcccgtg ttgtggacct gacactttaa ttccaccgcc      660



ccctgcggat gcttctctgt tacctgaggg gctgaggacc tcccagttat taccttgctc      720



acccagcaag cagtcagagg atggtcccaa accctccaac caagaaggga agtcccctgc      780



tcggttccag ttcacggagg aggacctgca cttcgttctg tacggggtca ctcccagcct      840



ggagcaccca gccagcctgc accatgcgat ttcaggcctc ctggtccccc cagacagctc      900



tggatctgat tctcttcctc aaactctgga taaagactcc cttcaacttc cagaaggtct      960



atgcctcatg cagacggtgt ttggtgaagt cccacatttt ggtgtgttct gcagtagttt     1020



tatcgccaaa ggagtcaggt ttgggccctt tcaaggtaaa gtggtcaatg ccagtgaagt     1080



gaagacctac ggagacaatt ctgtgatgtg ggagatcttt gaagatggtc atttgagcca     1140



ctttatagat ggaaaaggag gtacggggaa ctggatgtcc tatgtcaact gtgcccgctt     1200



ccccaaggag cagaacctag ttgctgtgca gtgtcaaggg catatatttt atgagagctg     1260



caaagagatc catcagaacc aagagctcct tgtgtggtat ggagactgct atgagaaatt     1320



tctggatatt cctgtgagcc ttcaggtcac agagccgggg aagcagccat ctgggccctc     1380



tgaagagtct gcagaaggct acagatgtga aagatgtggg aaggtattta cctacaaata     1440



ttacagagat aagcacctca agtacacccc ctgtgtggac aagggcgata ggaaatttcc     1500



ctgttctctc tgcaaacgat cctttgagaa gcgggaccgg cttcggatcc acattcttca     1560



tgttcatgag aagcaccggc ctcacaagtg ttctacatgt gggaaatgtt tctctcaatc     1620



ttccagccta aacaaacaca tgcgagtcca ctctggagac agaccatacc agtgtgtgta     1680



ttgtactaag aggttcacag cctccagcat actccgcaca cacatcaggc agcactccgg     1740



ggagaagccc ttcaaatgca agtactgtgg taaatctttt gcatcccatg ctgcccatga     1800



cagccatgtc cggcgttcac acaaggagga tgatggctgc tcatgcagca tctgtgggaa     1860



aatcttctca gatcaagaaa cattctactc ccacatgaag tttcatgaag actactagcc     1920



ctgccaggca caatgactca cgcctgtaat cccagcactt tgggaggcag aggtgggtgg     1980



atcactcaag tccaggagtt cgagaccagc ctgggcaaca tggtgaaatc ctgtctctac     2040



caaaaaaata caaaaatcag ctgggggtgg tggcacatgc ctgtggttcc agccactcag     2100



gaggtcgagg tggcaggatg gtttgagcac aggagacgga ggttgctgtg agctgagatc     2160



gccccactgc ttttcaacct gggtgacaga accagaccct gtctcaaaaa aaaaaaaaaa     2220



a                                                                     2221





<210>  251

<211>  571

<212>  PRT

<213>  Homo sapiens



<400>  251



Met Ala Leu Pro Arg Pro Ser Glu Ala Val Pro Gln Asp Lys Val Cys 

1               5                   10                  15      





Tyr Pro Pro Glu Ser Ser Pro Gln Asn Leu Ala Ala Tyr Tyr Thr Pro 

            20                  25                  30          





Phe Pro Ser Tyr Gly His Tyr Arg Asn Ser Leu Ala Thr Val Glu Glu 

        35                  40                  45              





Asp Phe Gln Pro Phe Arg Gln Leu Glu Ala Ala Ala Ser Ala Ala Pro 

    50                  55                  60                  





Ala Met Pro Pro Phe Pro Phe Arg Met Ala Pro Pro Leu Leu Ser Pro 

65                  70                  75                  80  





Gly Leu Gly Leu Gln Arg Glu Pro Leu Tyr Asp Leu Pro Trp Tyr Ser 

                85                  90                  95      





Lys Leu Pro Pro Trp Tyr Pro Ile Pro His Val Pro Arg Glu Val Pro 

            100                 105                 110         





Pro Phe Leu Ser Ser Ser His Glu Tyr Ala Gly Ala Ser Ser Glu Asp 

        115                 120                 125             





Leu Gly His Gln Ile Ile Gly Gly Asp Asn Glu Ser Gly Pro Cys Cys 

    130                 135                 140                 





Gly Pro Asp Thr Leu Ile Pro Pro Pro Pro Ala Asp Ala Ser Leu Leu 

145                 150                 155                 160 





Pro Glu Gly Leu Arg Thr Ser Gln Leu Leu Pro Cys Ser Pro Ser Lys 

                165                 170                 175     





Gln Ser Glu Asp Gly Pro Lys Pro Ser Asn Gln Glu Gly Lys Ser Pro 

            180                 185                 190         





Ala Arg Phe Gln Phe Thr Glu Glu Asp Leu His Phe Val Leu Tyr Gly 

        195                 200                 205             





Val Thr Pro Ser Leu Glu His Pro Ala Ser Leu His His Ala Ile Ser 

    210                 215                 220                 





Gly Leu Leu Val Pro Pro Asp Ser Ser Gly Ser Asp Ser Leu Pro Gln 

225                 230                 235                 240 





Thr Leu Asp Lys Asp Ser Leu Gln Leu Pro Glu Gly Leu Cys Leu Met 

                245                 250                 255     





Gln Thr Val Phe Gly Glu Val Pro His Phe Gly Val Phe Cys Ser Ser 

            260                 265                 270         





Phe Ile Ala Lys Gly Val Arg Phe Gly Pro Phe Gln Gly Lys Val Val 

        275                 280                 285             





Asn Ala Ser Glu Val Lys Thr Tyr Gly Asp Asn Ser Val Met Trp Glu 

    290                 295                 300                 





Ile Phe Glu Asp Gly His Leu Ser His Phe Ile Asp Gly Lys Gly Gly 

305                 310                 315                 320 





Thr Gly Asn Trp Met Ser Tyr Val Asn Cys Ala Arg Phe Pro Lys Glu 

                325                 330                 335     





Gln Asn Leu Val Ala Val Gln Cys Gln Gly His Ile Phe Tyr Glu Ser 

            340                 345                 350         





Cys Lys Glu Ile His Gln Asn Gln Glu Leu Leu Val Trp Tyr Gly Asp 

        355                 360                 365             





Cys Tyr Glu Lys Phe Leu Asp Ile Pro Val Ser Leu Gln Val Thr Glu 

    370                 375                 380                 





Pro Gly Lys Gln Pro Ser Gly Pro Ser Glu Glu Ser Ala Glu Gly Tyr 

385                 390                 395                 400 





Arg Cys Glu Arg Cys Gly Lys Val Phe Thr Tyr Lys Tyr Tyr Arg Asp 

                405                 410                 415     





Lys His Leu Lys Tyr Thr Pro Cys Val Asp Lys Gly Asp Arg Lys Phe 

            420                 425                 430         





Pro Cys Ser Leu Cys Lys Arg Ser Phe Glu Lys Arg Asp Arg Leu Arg 

        435                 440                 445             





Ile His Ile Leu His Val His Glu Lys His Arg Pro His Lys Cys Ser 

    450                 455                 460                 





Thr Cys Gly Lys Cys Phe Ser Gln Ser Ser Ser Leu Asn Lys His Met 

465                 470                 475                 480 





Arg Val His Ser Gly Asp Arg Pro Tyr Gln Cys Val Tyr Cys Thr Lys 

                485                 490                 495     





Arg Phe Thr Ala Ser Ser Ile Leu Arg Thr His Ile Arg Gln His Ser 

            500                 505                 510         





Gly Glu Lys Pro Phe Lys Cys Lys Tyr Cys Gly Lys Ser Phe Ala Ser 

        515                 520                 525             





His Ala Ala His Asp Ser His Val Arg Arg Ser His Lys Glu Asp Asp 

    530                 535                 540                 





Gly Cys Ser Cys Ser Ile Cys Gly Lys Ile Phe Ser Asp Gln Glu Thr 

545                 550                 555                 560 





Phe Tyr Ser His Met Lys Phe His Glu Asp Tyr 

                565                 570     





<210>  252

<211>  3284

<212>  DNA

<213>  Homo sapiens



<400>  252

ttctagacag tcccagcacc atgagccctg aaaggtccca agaggagagc ccagaaggag       60



acacagagag aacagagcgg aagcccatgg tcaaagatgc cttcaaagac atttccatat      120



acttcaccaa ggaagaatgg gcagaaatgg gagactggga gaaaactcgc tataggaatg      180



tgaaaatgaa ctataatgca ctgattactg taggtctcag agccactcga ccagctttca      240



tgtgtcaccg aaggcaggcc atcaaactcc aggtggatga cacagaagat tccgatgaag      300



aatggacacc taggcagcaa gtcaaacctc cttggatggc cttcagagga gaacagagta      360



aacaccagaa gggaatgccc aaggcgtcat tcaataatga atctagtttg agagaattgt      420



caggaacgcc aaatttactg aatacaagtg actcagagca ggctcagaaa ccagtgtccc      480



ctcctggaga agcaagtacc tctggacagc actctagact aaaactggaa ctcaggagga      540



aggagactga aggaaagatg tatagcctgc gagaaagaaa gggtcatgca tacaaagaga      600



tcagcgagcc acaggatgat gactacctct attgtgagat gtgtcagaac ttcttcattg      660



acagctgtgc tgctcatggg ccccctacat ttgtaaagga cagtgcagtg gacaaggggc      720



atcccaaccg ttcagccctc agtctgcccc cggggctgag aattgggcca tcaggcatcc      780



ctcaggctgg gcttggagta tggaacgagg catctgatct gccactgggt ctgcactttg      840



gcccctatga gggccgaatt acagaagacg aagaggcagc caacagtgga tattcctggc      900



taatcaccaa ggggagaaac tgctatgagt atgtggatgg aaaagataaa tcctcggcca      960



actggatgag gtatgtgaac tgtgcccggg atgatgaaga gcagaacctg gtggccttcc     1020



agtaccacag gcagatcttc tatagaacct gccgagtcat taggccaggc tgtgaactgc     1080



tggtctggtc tggggatgag tatggccagg aactgggcat cagatcttct atagaacctg     1140



ccgagtcatt aggccaggct gtgaactgct ggtctggtat ggggatgagt atggccagga     1200



actgggcatc aagtggggca gcaagtggaa gaaagagctc atggcaggga gagaaccaaa     1260



gccagagatc catccatgtc cctcatgctg tctggccttt tcaagtcaaa aatttctcag     1320



tcaacatgtg gaacgcaatc actcctctca gaacttccca ggaccatctg caagaaaact     1380



tctccaacca gagaatccct gcccagggga tcagaatcag gagcggcaat attctgatcc     1440



acgctgctgt aatgacaaaa ccaaaggtca agagatcaaa gaaaggtcca aactcttgaa     1500



taaaaggaca tggcagaggg agatttcaag ggccttttct agcccaccca aaggacaaat     1560



ggggagctct agagtgggag aaagaatgat ggaagaagag tccagaacag gccagaaagt     1620



gaatccaggg aacacaggca aattatttgt gggggtagga atctcaagaa ttgcgaaagt     1680



caaatatgga gagtgtgggc aaggtttcag tgataagtca gatgttatta cacaccaaag     1740



gacacacaca ggggggaagc cctacgtctg cagagagtgt gggagggctt tagccggaag     1800



tcagacctcc tcagtcacca gaggacacac acaggggaga agccttatgt ctgcagagag     1860



tgtgagcggg gctttagccg gaagtcagtc ctcctcattc accagaggac acacagggga     1920



gacgccccag tctgcaggaa ggatgagtaa gtcattagta ataaaacctt atctcaatag     1980



ccacaagaag acaaacgtga tcaccacaca cttgcacacc ccagctctga ggtggcttca     2040



gcgaaagtct gctaacccct tacattcccc gagagtgtaa agagatcgga aataactaat     2100



taaacaaatc cgccactttc atgactagag ttgaggaaga acaggggata gttctgtaag     2160



tgttcggggg acgtcaacat gtgtggttgt ttcccgcact gatcccctcc attttttgtg     2220



ttttgcctcc tgttctaatt aattttgtct ccatacatat ctgaacccca agtgtgtacc     2280



tcattcttcc cttatcactg aaggaaggaa gagtccagaa gggccacaga gaactcaaac     2340



gttcagttca agtctccaca ggaattcaac cccagaaaga cataaacttg gagtccatct     2400



ggtttaatta ttggagaatc gattcccaag tccaggaaga gaaatgtagg gttttacaga     2460



gtcgcagcag gaaagagagc tccctggtct cctgggaagt gtgacctctt ctaatggacc     2520



cctctcctct gctgccatac tcccccttgg ctccccctgt ctcctctcct gatttcctcc     2580



aatctctgta gccccagaag tgaacgccag acaggaacac gcatgtgtgt atatatgtgt     2640



tcacgtgtgc tatgtgtgtt aagcctgcat gcatgggtgt gggggtatgt gccctctgtg     2700



tacgtatctg tgtgagtgtg ggggtttcaa gggtgtatta ggaataacgc tcaaaatcct     2760



aaggaaattg aatactctga gagaagagag acagaccctc tcatactgtt ttatattgtt     2820



ttatactcag aaaaggaaaa agaagcaaaa ctaaaggcag gtagcctggc gcctaggaac     2880



cagacctgaa accaaggaac cagacccgaa accaggcctg ggccggcctg acctaagcct     2940



ggtagttaaa attcgacccc tgacctagca actgatgtta tctatagatt atagaaagac     3000



attgtgaaac ttcccggtct gttctgttcc actctgacca tcggtgcatg cagcccctgt     3060



cacctacccc ctgcttgctc aatcgatcac gaccctctca cgtggacccc cttagagttg     3120



tgagccctta aaagggacag gaattgctca ctcggggagc tcggctcttg agacagcagt     3180



cttgctgatg ctcctggccg aataaaccgc ttccttcttt aaaaaaaaaa aaaaaaaaaa     3240



aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      3284





<210>  253

<211>  492

<212>  PRT

<213>  Homo sapiens



<400>  253



Met Ser Pro Glu Arg Ser Gln Glu Glu Ser Pro Glu Gly Asp Thr Glu 

1               5                   10                  15      





Arg Thr Glu Arg Lys Pro Met Val Lys Asp Ala Phe Lys Asp Ile Ser 

            20                  25                  30          





Ile Tyr Phe Thr Lys Glu Glu Trp Ala Glu Met Gly Asp Trp Glu Lys 

        35                  40                  45              





Thr Arg Tyr Arg Asn Val Lys Met Asn Tyr Asn Ala Leu Ile Thr Val 

    50                  55                  60                  





Gly Leu Arg Ala Thr Arg Pro Ala Phe Met Cys His Arg Arg Gln Ala 

65                  70                  75                  80  





Ile Lys Leu Gln Val Asp Asp Thr Glu Asp Ser Asp Glu Glu Trp Thr 

                85                  90                  95      





Pro Arg Gln Gln Val Lys Pro Pro Trp Met Ala Phe Arg Gly Glu Gln 

            100                 105                 110         





Ser Lys His Gln Lys Gly Met Pro Lys Ala Ser Phe Asn Asn Glu Ser 

        115                 120                 125             





Ser Leu Arg Glu Leu Ser Gly Thr Pro Asn Leu Leu Asn Thr Ser Asp 

    130                 135                 140                 





Ser Glu Gln Ala Gln Lys Pro Val Ser Pro Pro Gly Glu Ala Ser Thr 

145                 150                 155                 160 





Ser Gly Gln His Ser Arg Leu Lys Leu Glu Leu Arg Arg Lys Glu Thr 

                165                 170                 175     





Glu Gly Lys Met Tyr Ser Leu Arg Glu Arg Lys Gly His Ala Tyr Lys 

            180                 185                 190         





Glu Ile Ser Glu Pro Gln Asp Asp Asp Tyr Leu Tyr Cys Glu Met Cys 

        195                 200                 205             





Gln Asn Phe Phe Ile Asp Ser Cys Ala Ala His Gly Pro Pro Thr Phe 

    210                 215                 220                 





Val Lys Asp Ser Ala Val Asp Lys Gly His Pro Asn Arg Ser Ala Leu 

225                 230                 235                 240 





Ser Leu Pro Pro Gly Leu Arg Ile Gly Pro Ser Gly Ile Pro Gln Ala 

                245                 250                 255     





Gly Leu Gly Val Trp Asn Glu Ala Ser Asp Leu Pro Leu Gly Leu His 

            260                 265                 270         





Phe Gly Pro Tyr Glu Gly Arg Ile Thr Glu Asp Glu Glu Ala Ala Asn 

        275                 280                 285             





Ser Gly Tyr Ser Trp Leu Ile Thr Lys Gly Arg Asn Cys Tyr Glu Tyr 

    290                 295                 300                 





Val Asp Gly Lys Asp Lys Ser Ser Ala Asn Trp Met Arg Tyr Val Asn 

305                 310                 315                 320 





Cys Ala Arg Asp Asp Glu Glu Gln Asn Leu Val Ala Phe Gln Tyr His 

                325                 330                 335     





Arg Gln Ile Phe Tyr Arg Thr Cys Arg Val Ile Arg Pro Gly Cys Glu 

            340                 345                 350         





Leu Leu Val Trp Ser Gly Asp Glu Tyr Gly Gln Glu Leu Gly Ile Arg 

        355                 360                 365             





Ser Ser Ile Glu Pro Ala Glu Ser Leu Gly Gln Ala Val Asn Cys Trp 

    370                 375                 380                 





Ser Gly Met Gly Met Ser Met Ala Arg Asn Trp Ala Ser Ser Gly Ala 

385                 390                 395                 400 





Ala Ser Gly Arg Lys Ser Ser Trp Gln Gly Glu Asn Gln Ser Gln Arg 

                405                 410                 415     





Ser Ile His Val Pro His Ala Val Trp Pro Phe Gln Val Lys Asn Phe 

            420                 425                 430         





Ser Val Asn Met Trp Asn Ala Ile Thr Pro Leu Arg Thr Ser Gln Asp 

        435                 440                 445             





His Leu Gln Glu Asn Phe Ser Asn Gln Arg Ile Pro Ala Gln Gly Ile 

    450                 455                 460                 





Arg Ile Arg Ser Gly Asn Ile Leu Ile His Ala Ala Val Met Thr Lys 

465                 470                 475                 480 





Pro Lys Val Lys Arg Ser Lys Lys Gly Pro Asn Ser 

                485                 490         





<210>  254

<211>  2504

<212>  DNA

<213>  Homo sapiens



<400>  254

atcattccct tactcgaatg aattaaagta caggattggg gctaaataat gtgagtgcca       60



cgctctttct gaagctctta tatcaaggaa catgcattac aactttccta atccctgctt      120



ccctcacttc cagattgtga gatgtgtcag aacttcttca ttgacagctg tgctgctcat      180



gggcccccta catttgtaaa ggacagtgca gtggacaagg ggcatcccaa ccgttcagcc      240



ctcagtctgc ccccggggct gagaattggg ccatcaggca tccctcaggc tgggcttgga      300



gtatggaacg aggcatctga tctgccactg ggtctgcact ttggccccta tgagggccga      360



attacagaag acgaagaggc agccaacagt ggatattcct ggctaatcac caaggggaga      420



aactgctatg agtatgtgga tggaaaagat aaatcctcgg ccaactggat gagaaccaaa      480



gccagagatc catccatgtc cctcatgctg tctggccttt tcaagtcaaa aatttctcag      540



tcaacatgtg gaacgcaatc actcctctca gaacttccca ggaccatctg caagaaaact      600



tctccaacca gagaatccct gcccagggga tcagaatcag gagcggcaat attctgatcc      660



acgctgctgt aatgacaaaa ccaaaggtca agagatcaaa gaaaggtcca aactcttgaa      720



taaaaggaca tggcagaggg agatttcaag ggccttttct agcccaccca aaggacaaat      780



ggggagctct agagtgggag aaagaatgat ggaagaagag tccagaacag gccagaaagt      840



gaatccaggg aacacaggca aattatttgt gggggtagga atctcaagaa ttgcgaaagt      900



caaatatgga gagtgtgggc aaggtttcag tgataagtca gatgttatta cacaccaaag      960



gacacacaca ggggggaagc cctacgtctg cagagagtgt gggagggctt tagccggaag     1020



tcagacctcc tcagtcacca gaggacacac acaggggaga agccttatgt ctgcagagag     1080



tgtgagcggg gctttagccg gaagtcagtc ctcctcattc accagaggac acacagggga     1140



gacgccccag tctgcaggaa ggatgagtaa gtcattagta ataaaacctt atctcaatag     1200



ccacaagaag acaaacgtga tcaccacaca cttgcacacc ccagctctga ggtggcttca     1260



gcgaaagtct gctaacccct tacattcccc gagagtgtaa agagatcgga aataactaat     1320



taaacaaatc cgccactttc atgactagag ttgaggaaga acaggggata gttctgtaag     1380



tgttcggggg acgtcaacat gtgtggttgt ttcccgcact gatcccctcc attttttgtg     1440



ttttgcctcc tgttctaatt aattttgtct ccatacatat ctgaacccca agtgtgtacc     1500



tcattcttcc cttatcactg aaggaaggaa gagtccagaa gggccacaga gaactcaaac     1560



gttcagttca agtctccaca ggaattcaac cccagaaaga cataaacttg gagtccatct     1620



ggtttaatta ttggagaatc gattcccaag tccaggaaga gaaatgtagg gttttacaga     1680



gtcgcagcag gaaagagagc tccctggtct cctgggaagt gtgacctctt ctaatggacc     1740



cctctcctct gctgccatac tcccccttgg ctccccctgt ctcctctcct gatttcctcc     1800



aatctctgta gccccagaag tgaacgccag acaggaacac gcatgtgtgt atatatgtgt     1860



tcacgtgtgc tatgtgtgtt aagcctgcat gcatgggtgt gggggtatgt gccctctgtg     1920



tacgtatctg tgtgagtgtg ggggtttcaa gggtgtatta ggaataacgc tcaaaatcct     1980



aaggaaattg aatactctga gagaagagag acagaccctc tcatactgtt ttatattgtt     2040



ttatactcag aaaaggaaaa agaagcaaaa ctaaaggcag gtagcctggc gcctaggaac     2100



cagacctgaa accaaggaac cagacccgaa accaggcctg ggccggcctg acctaagcct     2160



ggtagttaaa attcgacccc tgacctagca actgatgtta tctatagatt atagaaagac     2220



attgtgaaac ttcccggtct gttctgttcc actctgacca tcggtgcatg cagcccctgt     2280



cacctacccc ctgcttgctc aatcgatcac gaccctctca cgtggacccc cttagagttg     2340



tgagccctta aaagggacag gaattgctca ctcggggagc tcggctcttg agacagcagt     2400



cttgctgatg ctcctggccg aataaaccgc ttccttcttt aaaaaaaaaa aaaaaaaaaa     2460



aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      2504





<210>  255

<211>  171

<212>  PRT

<213>  Homo sapiens



<400>  255



Met Cys Gln Asn Phe Phe Ile Asp Ser Cys Ala Ala His Gly Pro Pro 

1               5                   10                  15      





Thr Phe Val Lys Asp Ser Ala Val Asp Lys Gly His Pro Asn Arg Ser 

            20                  25                  30          





Ala Leu Ser Leu Pro Pro Gly Leu Arg Ile Gly Pro Ser Gly Ile Pro 

        35                  40                  45              





Gln Ala Gly Leu Gly Val Trp Asn Glu Ala Ser Asp Leu Pro Leu Gly 

    50                  55                  60                  





Leu His Phe Gly Pro Tyr Glu Gly Arg Ile Thr Glu Asp Glu Glu Ala 

65                  70                  75                  80  





Ala Asn Ser Gly Tyr Ser Trp Leu Ile Thr Lys Gly Arg Asn Cys Tyr 

                85                  90                  95      





Glu Tyr Val Asp Gly Lys Asp Lys Ser Ser Ala Asn Trp Met Arg Thr 

            100                 105                 110         





Lys Ala Arg Asp Pro Ser Met Ser Leu Met Leu Ser Gly Leu Phe Lys 

        115                 120                 125             





Ser Lys Ile Ser Gln Ser Thr Cys Gly Thr Gln Ser Leu Leu Ser Glu 

    130                 135                 140                 





Leu Pro Arg Thr Ile Cys Lys Lys Thr Ser Pro Thr Arg Glu Ser Leu 

145                 150                 155                 160 





Pro Arg Gly Ser Glu Ser Gly Ala Ala Ile Phe 

                165                 170     





<210>  256

<211>  6054

<212>  DNA

<213>  Homo sapiens



<400>  256

cacgcggcta ccgagctgga ggaggcggcg ggcgcgagac ccggaatgcg cagggccccc       60



gcctcgcccc ccccagcccg ggccgcggcc cccgccttcc ccgcagtcgt cccgcactcg      120



gtgcccgccc cccgaggccg gcggctgctc ccactcgggg ccgttgctgc ttgtgccgtg      180



agcgccgccc agccattgtc cccgtcgctc cgtcagccgc gccggaccgc gcaccaggag      240



gcgagagcgc gcatggggag cctctgttga tgccgccgcc gcgccgccct ccgaggctgc      300



gtcccgggaa gcccggctcc ccgagcgctc cggcctggcc cggtgccccg gacctgagtg      360



cgtccccatg gaggcgcccg ggctggccca ggcggccgcg gcggagagcg actcccgcaa      420



ggtggcggag gagacccccg acggggcgcc cgcgctctgc cccagccctg aggcgctgtc      480



gccggagccg cctgtgtaca gcctgcagga ctttgacacg ctggccaccg tgggcactgg      540



gacgttcggg cgggtgcacc tggtgaagga gaagacagcc aagcatttct tcgccctcaa      600



ggtgatgagc attcccgacg tcatccgcct aaagcaggag caacacgtac acaatgagaa      660



gtctgtcctg aaggaagtca gccacccgtt cctcatcagg ctgttctgga cgtggcatga      720



cgagcgcttc ctctacatgc tcatggagta cgtgccgggc ggcgagctct tcagctacct      780



gcgcaaccgg gggcgcttct ccagcaccac ggggctcttc tactctgcag agatcatctg      840



tgccatcgag tacctgcact ccaaagagat cgtctacagg gacttgaagc cagagaacat      900



cctgctggat agggatggcc acattaagct cacggacttt gggttcgcca agaagctggt      960



agacaggact tggaccctct gtggaacacc cgagtaccta gcccccgaag tcattcagag     1020



caagggccac ggaagggccg tggactggtg ggccctcggc atcctgatat tcgagatgct     1080



ttcggggttt cctccgtttt ttgatgacaa cccgtttggc atttatcaga aaattcttgc     1140



aggcaaaata gatttcccca gacatttgga tttccatgta aaagacctca ttaagaaact     1200



gctcgtggtt gacagaacaa ggcgattagg aaacatgaag aacggggcga atgatgtgaa     1260



gcatcatcgg tggttccgct ccgtggactg ggaagctgtt ccgcagagaa aactgaagcc     1320



tcccatcgtg cccaagatag ctggtgacgg cgacacttcc aacttcgaaa cttaccctga     1380



gaatgactgg gacacagccg cgcccgtgcc gcagaaggat ttagaaatct tcaagaattt     1440



ctgaggacag gagctcacat ctggaagaaa caggaagatt ggaatctgcc tggaacaaag     1500



aactgcacct aagcagacca gaagcaaaat gtcttcttca cggcataagg acatctccac     1560



ttttctctgt acctgtgtgt atagaaatag attagagcac agttgaaatt catggaactg     1620



gcattattta agcaactgga attccacact gtaggaaggt tttgaaaatt gtttggttgt     1680



agattttatc ttatccttta gtgttgtgtt cctactgtga tgtcttggtt tttgtcatag     1740



acttaagttt ataagtttga actggacttg ttcgattata accacaaatt gtgtgtgtgt     1800



gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatgcct gtgtgtatat atagaagtca     1860



ttatggcaga tgcacagaaa ttgtgcagtg atgtaaatgt tcatacttta cagagcctat     1920



aatttttatt tttcaatttg ttttttcaaa aatctcttct cggggacaac atctgaaggg     1980



tatgttgcat gcattaaaaa aaatcatctc acatgcattt tatagttttg gggaagaaaa     2040



tatcatgggg aggtctacct tcagtatctt tagtgcttct tacctggtaa cttgagactt     2100



taaaagaaga aacaaagagg ggaagatatg ggagcgaatt tattccaaga atctacaatg     2160



acattgaagt tgttggagga atgtactgta tttaaaaaaa ccttctgtga cacattcaaa     2220



aatttcatct gagctggatg cagtggcttg ttcctatagt cccagcactt tgggaggctg     2280



aggtgggtgg attgcttgag cccaggagtt ggagaccagt ctgggaaacg tggtgagacc     2340



tcatctctac aaaatacaaa aaaattagcc gggcatggtg gcacgtgagt gtagtctcag     2400



ctactcagga ggctgagatg agaggatcac ttgagcctgg ggaggtccag gccgcagtga     2460



tccgagatca caccactgca ttccagcctg ggtgacagag tgagaccctg tccaaaaaaa     2520



aaaaaaaaaa aaaagaaggc aatggctttg tgcttttgaa gatggattga agagaacgtc     2580



caccttaagg ctttaaaaga cagtgaagct gggtgcggtg gtgcactcct gtaaccctgg     2640



gactttggga agctgaggca ggaagattga gcctaggagt tcgagaccga cctgggcagc     2700



atagcgagac cccatctcta tataaaaaaa aagatgttaa aacagtgaaa ttacagaaac     2760



agaacatagc cacccttttt catcagtgac cttttcttca cgtggaggtc aactcagtag     2820



gtgagaataa ttagtaggtt cagcagaata aactctttac aattaataac tcagtggaaa     2880



atgatgttca gatggtgaaa tgtggaaatg ttttagacaa ctctattttc agcctgtgct     2940



tctcactcac catcctgttg ggattaacag ttgagggcca tcgctgccta aacatttagc     3000



gtgcggtttc ccatcagttt taccgtgaat gtgaaaaggt gaaactggtg ctgacttcgg     3060



cagcaggtat actaaaattg gaatgacaca gaggagatta gcatggcccc ctgcgcgagg     3120



aagatctgca gattcatgca gcattccata tttttttaag aaaaggttac actgtgcacc     3180



gacatgtgga gctagaagga aaagctttta agtctcatgt ttgctgacta taaaaataaa     3240



tcatagtaat aatattgaac attctacttt aaaaattatt aataaaacca taaatgaaac     3300



acttgagcac actttaaaaa gtacataaat ccatgagtcc atatgcctat ttttaggttg     3360



tctgttttat tatccaggat ttcatactca gatgagaatt agcatcagga aagcctgaaa     3420



tgccttaatt gtgaactgat atgcaggaaa atgaaatatg caagcacatt ggtgaccttg     3480



ttctttacag acgtcgtgat cagcctccag ccatacagaa caaatgagaa attagaagcg     3540



attccaagaa cgtgtgatgg tgtgaaaccc actttggacc atcacacaca tttcagcatt     3600



tgaagtgaca caagctacct ggtaactgcc catggcgggg tcatagttta aatggcccaa     3660



tgtcatgtag aggttaattt aatcaaaatg agctataaac atggagcaat cactgtataa     3720



ttttaaaata gtttacctgg ccaggcatgg tggctcacgc ctgtaatccc agcactttgg     3780



gaggccgagg caggtggatc acctgaggtc aggagttcga gaccagcctg gccaacatgg     3840



caaaaccccc atctctacta aaatacaaaa attaggtgtg gtggcgggca cctgtaatcc     3900



tggctactcg ggaggctgag gcaggagaat cgcttgaacc cgggaggcag aggctgcagt     3960



aagccgagat cgtgccactg cactccagcc tgggccacag agcaagactc cgtctcaaaa     4020



cataaaaata aaaaaaatac aaatagctga cccgggtggg cattccaaaa tgtccgcatg     4080



gacgatcacg aaacaatcac ggtgcgaaat gtccgcatgg atgatcacga aacaatcacg     4140



gtgcagaatg tccgtatgga tgatcatgac aaacaatcac tgcgcaaaat gtggaggaaa     4200



attcattacc ataatcacaa catttgtatc agaaaaacat tacaaattta ctttgcttca     4260



tgtaatttta cgagttggca atattttctt aaattggaat actctaagag aataggacat     4320



ggatatgtta caagaagaag tgtattgggg caagtcttgt ttttctgaag ggaaatgcca     4380



ccggcctgct ttcataggca ttgataaagc caggaaggaa ataaagtcac aaccaaatag     4440



tatacactgt ctctactgaa ttcttctaat tccttcgcaa cagaagtcta aatcctgctt     4500



agcctaaaca tatctatagc cagcgatggg caaattatat ttgctgtcag catgatagaa     4560



taagaagcag aaacccccca gcagtggggt aagattgcgc gcttcatccc ctcaaaatgc     4620



agttcagccc cactccctct ccatgcccat caaacaactg cacaatcact tgttactgaa     4680



tttcccattc agcgttttgt ttctttctgt ccatacttaa agaccaaatc atttgtttgc     4740



tttgaagaaa aagcaaaaac aagaacaaaa acaccaaatc atttgaaatc actgtccatt     4800



aaaaaaaatc accagtggaa ctaaacagtt gagtggtttg ggatgtgttc gccatttctg     4860



tgtttgacct acatggcctc taattctttg gaccattgta actgtgaaac tatggcttaa     4920



tactgttaaa gaccccaagg ctccactctg tagccaggtg cacctcaggc tgcacaaata     4980



ccccaccaga atgtcacaat cattcattgc tccagctact gagtgaacag ggtgcaagac     5040



agcactggct tgggttgtat ttttgcagcc agttaacttt gcatcaggtc tacacagtcc     5100



ttgcagcctt tgatttctcc agttgtagag atttgaaatg gggtgcccgg gttcctctcg     5160



tttttccttc aatctaccta gcatgcattt tacacacatt ggaggagtcg tatgcactgt     5220



ttttctgttg ctgatggagg caagcaggcc ttctaattag tctaacttaa acggatggga     5280



ttcacttaac aaaagcaaga agaaaagcac acgaacaggt gtcttaatgc atttggatag     5340



tttctttgcg gggtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     5400



cttggtgaag gtgaggggct gtattttcac caagcctttt cataatcaag tttgctttgc     5460



aaaccttatg gccttgcacc ccgcagaaca gtcccttcct aatagcaggg atgctctgtc     5520



atggttttct gtaaattatc gtgtgttggg aagttctgtt gaggcttagt ttgatcttcc     5580



atggtggaca cgtctgttct gtatgtaaaa ggcattacaa ttgtgtttta gcagatgaga     5640



cttgaagcct ttccacagtc cttgtgctct gagatggctg ttgagctctg ctcaactgtc     5700



gtagctgaat tctttctttg cgctgaacac tgggcagcct caccatgttg ccaacgtgct     5760



tctggggccc ctgtcactgc cgccggatgc cgcgcacaca ggcagagtgc cttggcaggt     5820



ttgtgcaccc cttggcgagc cagaactggg aaccccgcgg ggtgacccct tctcatgggg     5880



ggtcggggag gggagtgcct atttttaatc ctgtctgttt gttgcacaat ggaaatcact     5940



gtgatttgta catatgccct aggaaaattt tactgctgtc taatttatgt aataatactg     6000



ttgattccag gtttgtttaa taaaactttg tatcttttca gaaaaaaaaa aaaa           6054





<210>  257

<211>  358

<212>  PRT

<213>  Homo sapiens



<400>  257



Met Glu Ala Pro Gly Leu Ala Gln Ala Ala Ala Ala Glu Ser Asp Ser 

1               5                   10                  15      





Arg Lys Val Ala Glu Glu Thr Pro Asp Gly Ala Pro Ala Leu Cys Pro 

            20                  25                  30          





Ser Pro Glu Ala Leu Ser Pro Glu Pro Pro Val Tyr Ser Leu Gln Asp 

        35                  40                  45              





Phe Asp Thr Leu Ala Thr Val Gly Thr Gly Thr Phe Gly Arg Val His 

    50                  55                  60                  





Leu Val Lys Glu Lys Thr Ala Lys His Phe Phe Ala Leu Lys Val Met 

65                  70                  75                  80  





Ser Ile Pro Asp Val Ile Arg Leu Lys Gln Glu Gln His Val His Asn 

                85                  90                  95      





Glu Lys Ser Val Leu Lys Glu Val Ser His Pro Phe Leu Ile Arg Leu 

            100                 105                 110         





Phe Trp Thr Trp His Asp Glu Arg Phe Leu Tyr Met Leu Met Glu Tyr 

        115                 120                 125             





Val Pro Gly Gly Glu Leu Phe Ser Tyr Leu Arg Asn Arg Gly Arg Phe 

    130                 135                 140                 





Ser Ser Thr Thr Gly Leu Phe Tyr Ser Ala Glu Ile Ile Cys Ala Ile 

145                 150                 155                 160 





Glu Tyr Leu His Ser Lys Glu Ile Val Tyr Arg Asp Leu Lys Pro Glu 

                165                 170                 175     





Asn Ile Leu Leu Asp Arg Asp Gly His Ile Lys Leu Thr Asp Phe Gly 

            180                 185                 190         





Phe Ala Lys Lys Leu Val Asp Arg Thr Trp Thr Leu Cys Gly Thr Pro 

        195                 200                 205             





Glu Tyr Leu Ala Pro Glu Val Ile Gln Ser Lys Gly His Gly Arg Ala 

    210                 215                 220                 





Val Asp Trp Trp Ala Leu Gly Ile Leu Ile Phe Glu Met Leu Ser Gly 

225                 230                 235                 240 





Phe Pro Pro Phe Phe Asp Asp Asn Pro Phe Gly Ile Tyr Gln Lys Ile 

                245                 250                 255     





Leu Ala Gly Lys Ile Asp Phe Pro Arg His Leu Asp Phe His Val Lys 

            260                 265                 270         





Asp Leu Ile Lys Lys Leu Leu Val Val Asp Arg Thr Arg Arg Leu Gly 

        275                 280                 285             





Asn Met Lys Asn Gly Ala Asn Asp Val Lys His His Arg Trp Phe Arg 

    290                 295                 300                 





Ser Val Asp Trp Glu Ala Val Pro Gln Arg Lys Leu Lys Pro Pro Ile 

305                 310                 315                 320 





Val Pro Lys Ile Ala Gly Asp Gly Asp Thr Ser Asn Phe Glu Thr Tyr 

                325                 330                 335     





Pro Glu Asn Asp Trp Asp Thr Ala Ala Pro Val Pro Gln Lys Asp Leu 

            340                 345                 350         





Glu Ile Phe Lys Asn Phe 

        355             





<210>  258

<211>  829

<212>  DNA

<213>  Homo sapiens



<400>  258

tggggagtga aagcgaaagc ccgggcgact agccgggaga ccagagatct agcgactgaa       60



gcagcatggc caagccgtgt ggggtgcgcc tgagcgggga agcccgcaaa caggtggagg      120



tcttcagaca gaatcttttc caggaggctg aggaattcct ctacagattc ttgccacaga      180



aaatcatata cctgaatcag ctcttgcaag aggactccct caatgtggct gacttgactt      240



ccctccgggc cccactggac atccccatcc cagaccctcc acccaaggat gatgagatgg      300



aaacagataa gcaggagaag aaagaagtcc ataagtgtgg atttctccct gggaatgaga      360



aagtcctgtc cctgcttgcc ctggttaagc cagaagtctg gactctcaaa gagaaatgca      420



ttctggtgat tacatggatc caacacctga tccccaagat tgaagatgga aatgattttg      480



gggtagcaat ccaggagaag gtgctggaga gggtgaatgc cgtcaagacc aaagtggaag      540



ctttccagac aaccatttcc aagtacttct cagaacgtgg ggatgctgtg gccaaggcct      600



ccaaggagac tcatgtaatg gattaccggg ccttggtgca tgagcgagat gaggcagcct      660



atggggagct cagggccatg gtgctggacc tgagggcctt ctatgctgag ctttatcata      720



tcatcagcag caacctggag aaaattgtca acccaaaggg tgaagaaaag ccatctatgt      780



actgaacccg ggactagaag gaaaataaat gatctatatg ttgtgtgga                  829





<210>  259

<211>  239

<212>  PRT

<213>  Homo sapiens



<400>  259



Met Ala Lys Pro Cys Gly Val Arg Leu Ser Gly Glu Ala Arg Lys Gln 

1               5                   10                  15      





Val Glu Val Phe Arg Gln Asn Leu Phe Gln Glu Ala Glu Glu Phe Leu 

            20                  25                  30          





Tyr Arg Phe Leu Pro Gln Lys Ile Ile Tyr Leu Asn Gln Leu Leu Gln 

        35                  40                  45              





Glu Asp Ser Leu Asn Val Ala Asp Leu Thr Ser Leu Arg Ala Pro Leu 

    50                  55                  60                  





Asp Ile Pro Ile Pro Asp Pro Pro Pro Lys Asp Asp Glu Met Glu Thr 

65                  70                  75                  80  





Asp Lys Gln Glu Lys Lys Glu Val His Lys Cys Gly Phe Leu Pro Gly 

                85                  90                  95      





Asn Glu Lys Val Leu Ser Leu Leu Ala Leu Val Lys Pro Glu Val Trp 

            100                 105                 110         





Thr Leu Lys Glu Lys Cys Ile Leu Val Ile Thr Trp Ile Gln His Leu 

        115                 120                 125             





Ile Pro Lys Ile Glu Asp Gly Asn Asp Phe Gly Val Ala Ile Gln Glu 

    130                 135                 140                 





Lys Val Leu Glu Arg Val Asn Ala Val Lys Thr Lys Val Glu Ala Phe 

145                 150                 155                 160 





Gln Thr Thr Ile Ser Lys Tyr Phe Ser Glu Arg Gly Asp Ala Val Ala 

                165                 170                 175     





Lys Ala Ser Lys Glu Thr His Val Met Asp Tyr Arg Ala Leu Val His 

            180                 185                 190         





Glu Arg Asp Glu Ala Ala Tyr Gly Glu Leu Arg Ala Met Val Leu Asp 

        195                 200                 205             





Leu Arg Ala Phe Tyr Ala Glu Leu Tyr His Ile Ile Ser Ser Asn Leu 

    210                 215                 220                 





Glu Lys Ile Val Asn Pro Lys Gly Glu Glu Lys Pro Ser Met Tyr 

225                 230                 235                 





<210>  260

<211>  2614

<212>  DNA

<213>  Homo sapiens



<400>  260

cgactgaggc ggcgggcgga gcggcaggcg gcggcggcgc ggcagcggag cgcagcatca       60



tggcggaccg agacagcggc agcgagcagg gtggtgcggc gctgggttcg ggcggctccc      120



tggggcaccc cggctcgggc tcaggctccg gcgggggcgg tggtggcggc gggggcggcg      180



gcggcagtgg cggcggcggc ggcggggccc caggggggct gcagcacgag acgcaggagc      240



tggcctccaa gcgggtggac atccagaaca agcgcttcta cctggacgtg aagcagaacg      300



ccaagggccg cttcctgaag atcgccgagg tgggcgcggg cggcaacaag agccgcctta      360



ctctctccat gtcagtggcc gtggagttcc gcgactacct gggcgacttc atcgagcact      420



acgcgcagct gggccccagc cagccgccgg acctggccca ggcgcaggac gagccgcgcc      480



gggcgctcaa aagcgagttc ctggtgcgcg agaaccgcaa gtactacatg gatctcaagg      540



agaaccagcg cggccgcttc ctgcgcatcc gccagacggt caaccggggg cctggcctgg      600



gctccacgca gggccagacc attgcgctgc ccgcgcaggg gctcatcgag ttccgtgacg      660



ctctggccaa gctcatcgac gactacggag tggaggagga gccggccgag ctgcccgagg      720



gcacctcctt gactgtggac aacaagcgct tcttcttcga tgtgggctcc aacaagtacg      780



gcgtgtttat gcgagtgagc gaggtgaagc ccacctatcg caactccatc accgtgccct      840



acaaggtgtg ggccaagttc ggacacacct tctgcaagta ctcggaggag atgaagaaga      900



ttcaagagaa gcagagggag aagcgggctg cctgtgagca gcttcaccag cagcaacagc      960



agcagcagga ggagaccgcc gctgccaccc tgctactgca gggtgaggaa gaaggggaag     1020



aagattgatc aaactgaatg aaacccccac acacacacac atgcatacac acacacacac     1080



agccacacac acagaaaata tactgtaaag aaagagagaa aataaaaagt taaaaagtta     1140



aaaaaaaaaa aaaacctgtt aactccaagg gagcaccacc cacagaacct ccaccaactg     1200



acagtttctc ttcttgactt gccacccatc gctggatgtt gtccacttta tccaccatat     1260



aaaacagtaa gcagctgcta aaaacaaaaa aaatacaaaa agtaataaca ttatatgaac     1320



tgtgtttcct acttgattaa aaaatataaa gaactgagtg tttatttccc taattaacca     1380



agaacttttg tacacgttta agctattatt attaaaaagt gtttgcaaaa tggtcaagat     1440



tataatattg ctgaattata taaaagtcct tttcatgttg agctaacatt tgactttagc     1500



acaaaaaaga gatattttag aacacgtaaa ataatatttt tagtttttct cattttgtta     1560



ccaaatttca aaccttacat ggaggttatt atagtatatt tgacacccta tatacctgtg     1620



attagagatg tgtatatata tgagggctag gcatgctgtg tgtctgagct ttgtctaaat     1680



gttatgcaga agtttgtaga gttaaaggta cgtaggttta attcatgcaa ggtaaacaat     1740



aagtgctctc ttttatacaa tatgcattgc atctggacct taaacttata aaaatggtca     1800



gtgaaacttc tgtgaacatg aagaaattat taaaaaaggc atttaaatga aatttgctaa     1860



gttgtgattt ttatggttgg aaccaaagtt attcaaatag taaaaggaaa aagaaagaaa     1920



aaggagatct cccataatat ttttctgcat ctgtttgctt tgactgagta ggcgttttgt     1980



cattattgtg tatatgagat gtacttgtat cgttcataat atattttttt tattatgtgt     2040



agaaagattt taaaaaacta acgtgcagca atttccagtg aacctgtact tggacatcag     2100



gtagtgagtc tatttgtggt cactagcact gtctcctaaa cttgtaagag gtctgaagct     2160



attctttgat ttttgctagt gctattaact tatgtagacc tgttaaaaag cagagcaaca     2220



caattatagt tatcctactg agccatggat tctgagtttt gttttaaaag tgaaagccaa     2280



gttggtgtat gtaaaggatt tccatgtagc tgtggtgcta gttattactg gctacattat     2340



atgctaagtg tatttgtgtt ccccaagtgt acaagccttc tatcaaaagt atgttctata     2400



actcatatat tcaaggtgta gggtatgaaa atgcaaagtt taggagagca ctttaccaag     2460



ctggtgtcct ccaaactgaa attgtttgta acgatagtct tttacaggtt ttcctttaaa     2520



gatgtttgtg tgcttttaat tgacaactaa cttcttgctg ctgtatagta aaatattaat     2580



atatttttat cattaaactg ctgcatgact atca                                 2614





<210>  261

<211>  322

<212>  PRT

<213>  Homo sapiens



<400>  261



Met Ala Asp Arg Asp Ser Gly Ser Glu Gln Gly Gly Ala Ala Leu Gly 

1               5                   10                  15      





Ser Gly Gly Ser Leu Gly His Pro Gly Ser Gly Ser Gly Ser Gly Gly 

            20                  25                  30          





Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 

        35                  40                  45              





Gly Ala Pro Gly Gly Leu Gln His Glu Thr Gln Glu Leu Ala Ser Lys 

    50                  55                  60                  





Arg Val Asp Ile Gln Asn Lys Arg Phe Tyr Leu Asp Val Lys Gln Asn 

65                  70                  75                  80  





Ala Lys Gly Arg Phe Leu Lys Ile Ala Glu Val Gly Ala Gly Gly Asn 

                85                  90                  95      





Lys Ser Arg Leu Thr Leu Ser Met Ser Val Ala Val Glu Phe Arg Asp 

            100                 105                 110         





Tyr Leu Gly Asp Phe Ile Glu His Tyr Ala Gln Leu Gly Pro Ser Gln 

        115                 120                 125             





Pro Pro Asp Leu Ala Gln Ala Gln Asp Glu Pro Arg Arg Ala Leu Lys 

    130                 135                 140                 





Ser Glu Phe Leu Val Arg Glu Asn Arg Lys Tyr Tyr Met Asp Leu Lys 

145                 150                 155                 160 





Glu Asn Gln Arg Gly Arg Phe Leu Arg Ile Arg Gln Thr Val Asn Arg 

                165                 170                 175     





Gly Pro Gly Leu Gly Ser Thr Gln Gly Gln Thr Ile Ala Leu Pro Ala 

            180                 185                 190         





Gln Gly Leu Ile Glu Phe Arg Asp Ala Leu Ala Lys Leu Ile Asp Asp 

        195                 200                 205             





Tyr Gly Val Glu Glu Glu Pro Ala Glu Leu Pro Glu Gly Thr Ser Leu 

    210                 215                 220                 





Thr Val Asp Asn Lys Arg Phe Phe Phe Asp Val Gly Ser Asn Lys Tyr 

225                 230                 235                 240 





Gly Val Phe Met Arg Val Ser Glu Val Lys Pro Thr Tyr Arg Asn Ser 

                245                 250                 255     





Ile Thr Val Pro Tyr Lys Val Trp Ala Lys Phe Gly His Thr Phe Cys 

            260                 265                 270         





Lys Tyr Ser Glu Glu Met Lys Lys Ile Gln Glu Lys Gln Arg Glu Lys 

        275                 280                 285             





Arg Ala Ala Cys Glu Gln Leu His Gln Gln Gln Gln Gln Gln Gln Glu 

    290                 295                 300                 





Glu Thr Ala Ala Ala Thr Leu Leu Leu Gln Gly Glu Glu Glu Gly Glu 

305                 310                 315                 320 





Glu Asp 

        





<210>  262

<211>  1955

<212>  DNA

<213>  Homo sapiens



<400>  262

gcgggcgggg cctctggggc ggagcggcca ccatcttgga acgggaggcg gagcagagtc       60



gactgggagc gaccgagcgg gccgccgccg ccgccatgaa ccccgaatat gactacctgt      120



ttaagctgct tttgattggc gactcaggcg tgggcaagtc atgcctgctc ctgcggtttg      180



ctgatgacac gtacacagag agctacatca gcaccatcgg ggtggacttc aagatccgaa      240



ccatcgagct ggatggcaaa actatcaaac ttcagatctg ggacacagcg ggccaggaac      300



ggttccggac catcacttcc agctactacc ggggggctca tggcatcatc gtggtgtatg      360



acgtcactga ccaggaatcc tacgccaacg tgaagcagtg gctgcaggag attgaccgct      420



atgccagcga gaacgtcaat aagctcctgg tgggcaacaa gagcgacctc accaccaaga      480



aggtggtgga caacaccaca gccaaggagt ttgcagactc tctgggcatc cccttcttgg      540



agacgagcgc caagaatgcc accaatgtcg agcaggcgtt catgaccatg gctgctgaaa      600



tcaaaaagcg gatggggcct ggagcagcct ctgggggcga gcggcccaat ctcaagatcg      660



acagcacccc tgtaaagccg gctggcggtg gctgttgcta ggaggggcac atggagtggg      720



acaggagggg gcaccttctc cagatgatgt ccctggaggg ggcaggaggt acctccctct      780



ccctctcctg gggcatttga gtctgtggct ttggggtgtc ctgggctccc catctccttc      840



tggcccatct gcctgctgcc ctgagccccg gttctgtcag ggtccctaag ggaggacact      900



cagggcctgt ggccaggcag ggcggaggcc tgctgtgctg ttgcctctag gtgactttcc      960



aagatgcccc cctacacacc tttctttgga acgagggctc ttctgtcggt gtccctccca     1020



cccccatgta tgctgcactg ggttctctcc ttcttcttcc tgctgtcctg cccaagaact     1080



gagggtctcc ccggcctcta ctgccctggc tgcagtcagt gcccagggcg aggaatgtgg     1140



ccaggggatc caggacctgg gatccagggc cctgggctgg acctcaggac aggcatggag     1200



gccacagggg cccagcagcc caccctttcc tctccccact gcctcctctc ccttcctaca     1260



ctcccagctc gagccgtcca gctgcggtgg gatctgagta tatctagggc gggtgggcgg     1320



gtagcagtgc tgggcctgtg tcttgagcct ggagggagtc tgctcctgcc gccctctgcc     1380



ctgccagaga cagacccatg cgctgcctgc ccaccgtgcc cctttgtccc catgtcaggc     1440



ggaggcggaa ggcccaccgt gccagaggct gggcaccagc cttaaccctc actctgctag     1500



cacctcctcc ctttccccaa ggtagcacat ctggctcact ccccactccg tctctggagc     1560



ccaccaggga aggccctcat cccctgccgc tacttctctg gggaatgtgg gttccatcca     1620



ggattggggg cctctctgct cacccactct gcacccagga tcctagtccc ctgccctctg     1680



gcacagctgc ttcctgcaag aaagcaagtc tttggtctcc ctgagaagcc atgtccctcg     1740



tgctgtctct tgcctgtccc acctgtgccc tgccctccag cttgtattta agtccctggg     1800



ctgccccctt ggggtgcccc ccgctcccag gttcccctct ggtgtcatgt caggcatttt     1860



gcaaggaaaa gccacttggg gaaagatgga aaaggacaaa aaaaattaat aaatttccat     1920



tggccctcgg gtgagctgag ggtttttgca aggaa                                1955





<210>  263

<211>  201

<212>  PRT

<213>  Homo sapiens



<400>  263



Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp 

1               5                   10                  15      





Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Thr 

            20                  25                  30          





Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Arg 

        35                  40                  45              





Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr 

    50                  55                  60                  





Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Ser Ser Tyr Tyr Arg Gly 

65                  70                  75                  80  





Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr 

                85                  90                  95      





Ala Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr Ala Ser Glu 

            100                 105                 110         





Asn Val Asn Lys Leu Leu Val Gly Asn Lys Ser Asp Leu Thr Thr Lys 

        115                 120                 125             





Lys Val Val Asp Asn Thr Thr Ala Lys Glu Phe Ala Asp Ser Leu Gly 

    130                 135                 140                 





Ile Pro Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn Val Glu Gln 

145                 150                 155                 160 





Ala Phe Met Thr Met Ala Ala Glu Ile Lys Lys Arg Met Gly Pro Gly 

                165                 170                 175     





Ala Ala Ser Gly Gly Glu Arg Pro Asn Leu Lys Ile Asp Ser Thr Pro 

            180                 185                 190         





Val Lys Pro Ala Gly Gly Gly Cys Cys 

        195                 200     





<210>  264

<211>  1530

<212>  DNA

<213>  Homo sapiens



<400>  264

ccgcagaact gccacgtggg gatgagattt gctgggctgg tagcggcggc tgctgcggga       60



ggtcccgccc acgtgaagcc agcctaactg agctctggac tttggggaca gctgtcagtg      120



gcctaggccg caggacacca tgaagcaact gccagtcttg gaacctggag acaagcccag      180



gaaagcaaca tggtacacct tgactgtccc tggagacagc ccctgtgctc gagttggcca      240



cagctgttca tatttacccc cagttggtaa tgccaagaga gggaaggtct tcattgttgg      300



gggagcaaat ccaaacagaa gcttctcaga cgtgcacacc atggatctgg gaaaacacca      360



gtgggactta gatacctgca agggcctctt gccccggtat gaacatgcta gcttcattcc      420



ctcctgcaca cctgaccgta tctgggtatt tggaggtgcc aaccaatcag gaaatcgaaa      480



ttgtctacaa gtcctgaatc ctgaaaccag gacgtggacc acgccagaag tgaccagccc      540



cccaccatcc ccaagaacat tccacacatc atcggcagcc attggaaacc agctatatgt      600



ctttgggggc ggagagagag gtgcccagcc cgtgcaggac acgaagctgc atgtgtttga      660



cgcaaacact ctgacctggt cacagccaga gacacttgga aatcctccat ctccccggca      720



tggtcatgtg atggtggcag cagggacaaa gctcttcatc cacggaggct tggcggggga      780



cagattctat gatgacctcc actgcattga tataagtgac atgaaatggc agaagctaaa      840



tcccactggg gctgctccag caggctgtgc tgcccactca gctgtggcca tgggaaaaca      900



tgtgtacatc tttggtggaa tgactcctgc aggagcactg gacacaatgt accagtatca      960



cacagaagag cagcattgga ccttgcttaa atttgatact cttctacccc ctggacgatt     1020



ggaccattcc atgtgtatca ttccatggcc agtgacgtgt gcttctgaga aagaagattc     1080



caactctctc actctgaacc atgaagctga gaaagaggat tcagctgaca aagtaatgag     1140



ccacagtggt gactcacatg aggaaagcca gactgctaca ctgctctgtt tggtgtttgg     1200



tgggatgaat acagaagggg aaatctatga cgattgtatt gtgactgtag tggactaata     1260



aaacccacat ttttattacc tgtcagttac tttcagaata gttaagtaaa acattagctg     1320



ttttatacct ccaaaatatc ttctgcatta tatatctgtt tttctcctac tttggtaggt     1380



gaagaaacta atgcaaataa ttcttatgtg cactaaacct tgctatattg cctctcaaaa     1440



aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500



aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      1530





<210>  265

<211>  372

<212>  PRT

<213>  Homo sapiens



<400>  265



Met Lys Gln Leu Pro Val Leu Glu Pro Gly Asp Lys Pro Arg Lys Ala 

1               5                   10                  15      





Thr Trp Tyr Thr Leu Thr Val Pro Gly Asp Ser Pro Cys Ala Arg Val 

            20                  25                  30          





Gly His Ser Cys Ser Tyr Leu Pro Pro Val Gly Asn Ala Lys Arg Gly 

        35                  40                  45              





Lys Val Phe Ile Val Gly Gly Ala Asn Pro Asn Arg Ser Phe Ser Asp 

    50                  55                  60                  





Val His Thr Met Asp Leu Gly Lys His Gln Trp Asp Leu Asp Thr Cys 

65                  70                  75                  80  





Lys Gly Leu Leu Pro Arg Tyr Glu His Ala Ser Phe Ile Pro Ser Cys 

                85                  90                  95      





Thr Pro Asp Arg Ile Trp Val Phe Gly Gly Ala Asn Gln Ser Gly Asn 

            100                 105                 110         





Arg Asn Cys Leu Gln Val Leu Asn Pro Glu Thr Arg Thr Trp Thr Thr 

        115                 120                 125             





Pro Glu Val Thr Ser Pro Pro Pro Ser Pro Arg Thr Phe His Thr Ser 

    130                 135                 140                 





Ser Ala Ala Ile Gly Asn Gln Leu Tyr Val Phe Gly Gly Gly Glu Arg 

145                 150                 155                 160 





Gly Ala Gln Pro Val Gln Asp Thr Lys Leu His Val Phe Asp Ala Asn 

                165                 170                 175     





Thr Leu Thr Trp Ser Gln Pro Glu Thr Leu Gly Asn Pro Pro Ser Pro 

            180                 185                 190         





Arg His Gly His Val Met Val Ala Ala Gly Thr Lys Leu Phe Ile His 

        195                 200                 205             





Gly Gly Leu Ala Gly Asp Arg Phe Tyr Asp Asp Leu His Cys Ile Asp 

    210                 215                 220                 





Ile Ser Asp Met Lys Trp Gln Lys Leu Asn Pro Thr Gly Ala Ala Pro 

225                 230                 235                 240 





Ala Gly Cys Ala Ala His Ser Ala Val Ala Met Gly Lys His Val Tyr 

                245                 250                 255     





Ile Phe Gly Gly Met Thr Pro Ala Gly Ala Leu Asp Thr Met Tyr Gln 

            260                 265                 270         





Tyr His Thr Glu Glu Gln His Trp Thr Leu Leu Lys Phe Asp Thr Leu 

        275                 280                 285             





Leu Pro Pro Gly Arg Leu Asp His Ser Met Cys Ile Ile Pro Trp Pro 

    290                 295                 300                 





Val Thr Cys Ala Ser Glu Lys Glu Asp Ser Asn Ser Leu Thr Leu Asn 

305                 310                 315                 320 





His Glu Ala Glu Lys Glu Asp Ser Ala Asp Lys Val Met Ser His Ser 

                325                 330                 335     





Gly Asp Ser His Glu Glu Ser Gln Thr Ala Thr Leu Leu Cys Leu Val 

            340                 345                 350         





Phe Gly Gly Met Asn Thr Glu Gly Glu Ile Tyr Asp Asp Cys Ile Val 

        355                 360                 365             





Thr Val Val Asp 

    370         





<210>  266

<211>  6121

<212>  DNA

<213>  Homo sapiens



<400>  266

gaattccctt ttctgggcac cgccttctgc tagggggttg tagatgaaag tgcctgctcc       60



cagagaagct tgtctaacct agcacagttt ctaagctacc caggctgcca gaccgagcga      120



ccgtgctgcc atggacacag actctcagcg ttctcatctc tcttccttca ccatgaagct      180



gatggacaaa ttccactcac ccaaaatcaa gagaacgcca tcaaagaagg gaaaaccagc      240



tgaggtgtcc gtaaagattc cagagaagcc tgtgaacaaa gaggcaacag acagatttct      300



accagagggc taccctctcc ccttggatct ggagcagcag gcagtagaat ttatgtccac      360



cagtgctgtg gcttccaggt ctcaaaggca gaagaacctg agctggctgg aggagaaaga      420



gaaggaagtt gtcagtgccc tgcgctactt taagaccatt gtggacaaaa tggcaattga      480



taagaaggta ctggagatgc ttccagggtc agccagcaag gtgctggagg ccatcttacc      540



cctggtgcag aacgatcctc gaattcagca cagctcagcc ctctcttcct gctatagccg      600



agtgtaccaa agcctcgcca acctcattcg ctggtctgac caagtgatgc tggaaggcgt      660



gaactcagaa gacaaggaga tggtgacgac tgtgaagggg gtcatcaagg ctgtgctgga      720



tggagtgaag gagctggtca ggctcaccat cgagaagcag ggacgtccgt ctccgacgag      780



ccccgtgaag cccagttccc ctgccagcaa gcctgatggc ccagcagagc tccccctgac      840



agaccgcgag gtagagatcc taaacaagac gactgggatg tcacagtcaa ctgagctcct      900



cccagatgcc acggatgaag aggtcgcgcc ccccaagcct cctctgcctg gcattcgggt      960



ggttgataat agtcctccac cagcattgcc acccaagaaa agacagtcgg cgccgtcccc     1020



tacccgagtg gctgtggtgg cccccatgag ccgagccacc agtggctcca gtttgcctgt     1080



tggaatcaat aggcaggatt ttgatgttga ctgttacgca cagaggcgac tgtcaggagg     1140



cagccactca tatggtggag agtcgccccg cctctccccc tgcagcagca taggcaagct     1200



cagcaagtca gacgagcagc tgtcctctct ggacagggac agtgggcagt gctcccggaa     1260



cacaagctgt gaaacactag accactatga tcccgactat gaattcctcc agcaagacct     1320



ctctaacgca gaccagatac ctcagcagac ggcctggaac cttagcccgt tgccagagtc     1380



tttgggggag tctgggtctc catttcttgg ccctcctttc cagctgcctc ttggcggcca     1440



tccccagcca gacggacctc tggccccagg gcagcagaca gatacgccac ctgctctccc     1500



cgagaagaag cgcaggagcg cagcctccca gacggcggac ggctctggct gcagggtgtc     1560



ctacgagcgg catccctcgc agtatgacaa catctctggg gaggacctgc agagcacagc     1620



cccgatccca tccgtcccct acgcgccctt tgctgctatt ctgccctttc agcatggagg     1680



ttcctcagcc cctgtcgaat ttgtgggtga ttttactgct cctgagtcaa ccggtgaccc     1740



agaaaaacca cctcctctac cagagaagaa aaacaaacac atgctggcct acatgcagtt     1800



gctggaggac tactcggagc cgcagccctc tatgttctac cagacgccac agaacgagca     1860



catctaccag cagaagaaca agctcctcat ggaggtatac ggcttcagcg actccttcag     1920



tggggtggac tccgtgcagg agctggcccc gccgcccgcc ctacccccca agcagcggca     1980



gctggagcca ccggctggga aagacggaca tcccagagat ccctcagcgg tcagcggcgt     2040



ccctgggaag gacagcagag acggcagtga gagggcccca aagtcaccag atgctctgga     2100



gtcggctcag tcggaggagg aagtggacga gctgtccctc attgaccaca acgaaattat     2160



gtccaggctg acgctcaagc aggagggtga tgacgggccg gacgtccgcg gaggatctgg     2220



ggacatctta ctggtccatg ctactgagac tgacaggaaa gatttggtgt tgtactgcga     2280



ggcattcctg accacctaca ggaccttcat ctccccagag gagctcatca agaagctgca     2340



gtacagatat gagaaattct ctccctttgc cgacacattc aagaagcgcg tcagcaagaa     2400



cacgttcttc gtgctggtac gggtggtgga tgagctctgc ctggtggagt tgacagaaga     2460



gatcctgaag ctgctgatgg aactggtctt ccgcctggtg tgcaatgggg agctgagcct     2520



ggcccgtgtg ctccggaaga acatcctgga caaggtggac cagaagaagc tactcaggtg     2580



tgccacctcc agccagcccc tggcagcccg gggggtagca gccaggccgg ggaccttgca     2640



cgactttcac agccatgaga tagcggagca gctaacgctg ctggatgctg agctcttcta     2700



taaaatagag attcctgagg ttttgctttg ggcaaaagag cagaatgagg agaagagccc     2760



caacttgacc cagttcacgg agcacttcaa caacatgtcc tactgggtcc ggtccataat     2820



catgttacag gaaaaggccc aggacaggga acggctgctc ttgaagttca tcaagatcat     2880



gaagcacttg cggaagctga ataacttcaa ctcctacttg gccatcctct ctgccctgga     2940



ctcggcgccc atccgcaggc tggagtggca gaagcagact tcagagggcc tggccgagta     3000



ctgcacactg atcgacagct cgtcctcctt ccgagcctac cgggccgccc tctcggaggt     3060



ggaaccgccg tgcatcccgt acctggggct gatcctgcag gacctgacct tcgttcacct     3120



gggaaaccca gactacatcg acgggaaagt gaacttctcc aagcggtggc agcagttcaa     3180



catcctcgac agcatgcgct gcttccagca ggcgcactat gacatgcgga ggaacgacga     3240



cattataaac ttcttcaatg acttcagtga ccacctggct gaggaggccc tatgggaact     3300



gtctctgaaa attaaaccca ggaacataac aaggagaaaa acagaccggg aagagaagac     3360



ctaggagcag acgccgggat ccaggagaat gctcgagggg cgcagagggc agctcccaga     3420



ccggagagga ccttggacct gttaggcgca tggcaggagt cccggcctcg gagccatgag     3480



gctggccagc cctcagcggg gccgggcggg agctggagcc tgccagccgc ttcctgcctc     3540



cttcctctgt gggagcagac ccgtgggcct cagggcagcc agcaggcagg tcttgttgcc     3600



aatttacaaa ccggtggttt tctggtttgg ttttgttttc tgcttttact tccatctctc     3660



ccctcttgac cttccaccca ctcccctcca gggagagagc agcagagacc tcatcagcag     3720



accaaggaag tggtgggtgc tccccctccc taagctccag ggtccctgaa tcttctgaaa     3780



tctcaaatga gtggaggcct cctggggtgg cctgtcctgc aggggccctg gaatgggggc     3840



aagcagctgg gtgggcagaa tgcagagtag actcggggga ggatcctttc actttccgct     3900



tccccttctg atgcatggag gatggtgtga gcttttcagc aggcccggaa aggtacgcag     3960



gtgacgcctt agcagccccg cagctggtgc tctgccccgc ggtactggcg ccatcagggc     4020



ctcccttgcc cgcctgagag cagcagcagt ctctgtcatc ccgtcgcccc ttacccccca     4080



ccccaggcca ctgggcccct cccacaccac ctggggagct gagaagagga ggctggagta     4140



agggaggact tgatcatcca agaaatactt tttattgctg ggagtcttct gaacctcacc     4200



aaactgaggc cagagctgag ctcctggggg agttaattca gaggggagag gccagcacct     4260



ccctcctcca tcgctcgctg tgtgccttaa actccatctc atgtccctcc ccatcccctg     4320



gctttccctc cctccttgcc ccatcctggg ccagccagca gggctcctcc tctggctctt     4380



cagacctttc agccagtgct gtcagtgccc ctgggaggga agggcatccc tgaggcaccc     4440



gaatggtccc tcagggtgca gggaggcaga agcctggcca cagaggagcc tcctaaggca     4500



gcagctgcag caagcgcacc ctctccccac tctccccacg ccagagcggc ttccagagca     4560



gatgctgttt ccatcctcct cgtcaaaacc attctcgctg ctgagcttga caatctgggc     4620



aaggcttgtg gggcgcttga caaacagaat ctgccctgtg ccgcctggtt ccgtggcctc     4680



cagcatgagc ctgcaggcag ggcgctgcgg gaacccagtt gtgctgcccc agcccatgcc     4740



tccgggtctg ctgtgcatga atgagtgctc acttgtcccg ggtttaggac gtggtcaagt     4800



gaacagcagg gtctaactgt gcttacttag cccagttcaa acagaacaaa ggaaaaatat     4860



agaaagcaac atctgttgat catttaggtt tttttttaaa ccaccatgtc actttgagtc     4920



cttcatgggt ttttgaacag catttatcaa gaagaaaatg tgggcttttt cccctctccc     4980



gtgttttgtt tgtcctgtag atagagggag gaaagccgtg cagtggcagg cgggaccccc     5040



tctggtggcg ggaccccctc ttgcggtggt cttgcggggc cagccgggac ctgtcacttt     5100



attatttaag gagtgtgtgt gtagagtcgc tggcttatta acagtattgt gtgtgggttg     5160



ggtttttagt ttgttccttc tttttgaagt cccttcattt caatccttga ctctctctcc     5220



ccttcccttg cccagctctg ttgaatgctg ctgtgcgcgt gtgagggccg ctctgcacac     5280



agggcccttg ggttgtgtga actgaaattc tccctgtatt tgtgagactc gcaggagtcc     5340



ccatctgtag cacaggcaat gccagtgcca tgctgcagcc tcagaaacca ggcctctcac     5400



tccagcagca ggcagaaccg tgtctgtggt cgggtgctgt ccacagctct gtctgccttg     5460



ttcttgggct tgagctggat agaggtgggg tctcttcacc ttccctgaat tcagaacaga     5520



ccctgtgcct ggccccagtg tgcccaggca attccccagg ccctcactgg gagcccttgg     5580



tgttctgagc agcagggccc aggcagcaca tgagcagtgc ccaggggctc cctgcgtgag     5640



gacggcaagg tgcgatgtat gtctaactta ttgatggcag gcagccccct gtgcccccta     5700



agcctggccc tggttattgc tgagctctgt gctcagtgct gcggcctggc cgtggctcgt     5760



ctgttccttt ggggggcccg ggcgggttgt gggaatcagt cttcacagac agacgtgagc     5820



caggcggagg actcgttcct tgcagaggtc agtcctcacc tgcaggtgtc ggggtggggg     5880



ggggcaagga ggggcaggca cacaccatgt ctgacctgaa cccgattctg gggagcatct     5940



tcccgctccg gccccacgac ctccacaggg ttacattgta atatatatgc cccagctaac     6000



ctgtctgatg gtggcatctt cctgcagaca tttcaaacat gtaactttta tatgaaaaaa     6060



aataaacaca gatgaaagct gcccaatgcc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     6120



a                                                                     6121





<210>  267

<211>  1077

<212>  PRT

<213>  Homo sapiens



<400>  267



Met Asp Thr Asp Ser Gln Arg Ser His Leu Ser Ser Phe Thr Met Lys 

1               5                   10                  15      





Leu Met Asp Lys Phe His Ser Pro Lys Ile Lys Arg Thr Pro Ser Lys 

            20                  25                  30          





Lys Gly Lys Pro Ala Glu Val Ser Val Lys Ile Pro Glu Lys Pro Val 

        35                  40                  45              





Asn Lys Glu Ala Thr Asp Arg Phe Leu Pro Glu Gly Tyr Pro Leu Pro 

    50                  55                  60                  





Leu Asp Leu Glu Gln Gln Ala Val Glu Phe Met Ser Thr Ser Ala Val 

65                  70                  75                  80  





Ala Ser Arg Ser Gln Arg Gln Lys Asn Leu Ser Trp Leu Glu Glu Lys 

                85                  90                  95      





Glu Lys Glu Val Val Ser Ala Leu Arg Tyr Phe Lys Thr Ile Val Asp 

            100                 105                 110         





Lys Met Ala Ile Asp Lys Lys Val Leu Glu Met Leu Pro Gly Ser Ala 

        115                 120                 125             





Ser Lys Val Leu Glu Ala Ile Leu Pro Leu Val Gln Asn Asp Pro Arg 

    130                 135                 140                 





Ile Gln His Ser Ser Ala Leu Ser Ser Cys Tyr Ser Arg Val Tyr Gln 

145                 150                 155                 160 





Ser Leu Ala Asn Leu Ile Arg Trp Ser Asp Gln Val Met Leu Glu Gly 

                165                 170                 175     





Val Asn Ser Glu Asp Lys Glu Met Val Thr Thr Val Lys Gly Val Ile 

            180                 185                 190         





Lys Ala Val Leu Asp Gly Val Lys Glu Leu Val Arg Leu Thr Ile Glu 

        195                 200                 205             





Lys Gln Gly Arg Pro Ser Pro Thr Ser Pro Val Lys Pro Ser Ser Pro 

    210                 215                 220                 





Ala Ser Lys Pro Asp Gly Pro Ala Glu Leu Pro Leu Thr Asp Arg Glu 

225                 230                 235                 240 





Val Glu Ile Leu Asn Lys Thr Thr Gly Met Ser Gln Ser Thr Glu Leu 

                245                 250                 255     





Leu Pro Asp Ala Thr Asp Glu Glu Val Ala Pro Pro Lys Pro Pro Leu 

            260                 265                 270         





Pro Gly Ile Arg Val Val Asp Asn Ser Pro Pro Pro Ala Leu Pro Pro 

        275                 280                 285             





Lys Lys Arg Gln Ser Ala Pro Ser Pro Thr Arg Val Ala Val Val Ala 

    290                 295                 300                 





Pro Met Ser Arg Ala Thr Ser Gly Ser Ser Leu Pro Val Gly Ile Asn 

305                 310                 315                 320 





Arg Gln Asp Phe Asp Val Asp Cys Tyr Ala Gln Arg Arg Leu Ser Gly 

                325                 330                 335     





Gly Ser His Ser Tyr Gly Gly Glu Ser Pro Arg Leu Ser Pro Cys Ser 

            340                 345                 350         





Ser Ile Gly Lys Leu Ser Lys Ser Asp Glu Gln Leu Ser Ser Leu Asp 

        355                 360                 365             





Arg Asp Ser Gly Gln Cys Ser Arg Asn Thr Ser Cys Glu Thr Leu Asp 

    370                 375                 380                 





His Tyr Asp Pro Asp Tyr Glu Phe Leu Gln Gln Asp Leu Ser Asn Ala 

385                 390                 395                 400 





Asp Gln Ile Pro Gln Gln Thr Ala Trp Asn Leu Ser Pro Leu Pro Glu 

                405                 410                 415     





Ser Leu Gly Glu Ser Gly Ser Pro Phe Leu Gly Pro Pro Phe Gln Leu 

            420                 425                 430         





Pro Leu Gly Gly His Pro Gln Pro Asp Gly Pro Leu Ala Pro Gly Gln 

        435                 440                 445             





Gln Thr Asp Thr Pro Pro Ala Leu Pro Glu Lys Lys Arg Arg Ser Ala 

    450                 455                 460                 





Ala Ser Gln Thr Ala Asp Gly Ser Gly Cys Arg Val Ser Tyr Glu Arg 

465                 470                 475                 480 





His Pro Ser Gln Tyr Asp Asn Ile Ser Gly Glu Asp Leu Gln Ser Thr 

                485                 490                 495     





Ala Pro Ile Pro Ser Val Pro Tyr Ala Pro Phe Ala Ala Ile Leu Pro 

            500                 505                 510         





Phe Gln His Gly Gly Ser Ser Ala Pro Val Glu Phe Val Gly Asp Phe 

        515                 520                 525             





Thr Ala Pro Glu Ser Thr Gly Asp Pro Glu Lys Pro Pro Pro Leu Pro 

    530                 535                 540                 





Glu Lys Lys Asn Lys His Met Leu Ala Tyr Met Gln Leu Leu Glu Asp 

545                 550                 555                 560 





Tyr Ser Glu Pro Gln Pro Ser Met Phe Tyr Gln Thr Pro Gln Asn Glu 

                565                 570                 575     





His Ile Tyr Gln Gln Lys Asn Lys Leu Leu Met Glu Val Tyr Gly Phe 

            580                 585                 590         





Ser Asp Ser Phe Ser Gly Val Asp Ser Val Gln Glu Leu Ala Pro Pro 

        595                 600                 605             





Pro Ala Leu Pro Pro Lys Gln Arg Gln Leu Glu Pro Pro Ala Gly Lys 

    610                 615                 620                 





Asp Gly His Pro Arg Asp Pro Ser Ala Val Ser Gly Val Pro Gly Lys 

625                 630                 635                 640 





Asp Ser Arg Asp Gly Ser Glu Arg Ala Pro Lys Ser Pro Asp Ala Leu 

                645                 650                 655     





Glu Ser Ala Gln Ser Glu Glu Glu Val Asp Glu Leu Ser Leu Ile Asp 

            660                 665                 670         





His Asn Glu Ile Met Ser Arg Leu Thr Leu Lys Gln Glu Gly Asp Asp 

        675                 680                 685             





Gly Pro Asp Val Arg Gly Gly Ser Gly Asp Ile Leu Leu Val His Ala 

    690                 695                 700                 





Thr Glu Thr Asp Arg Lys Asp Leu Val Leu Tyr Cys Glu Ala Phe Leu 

705                 710                 715                 720 





Thr Thr Tyr Arg Thr Phe Ile Ser Pro Glu Glu Leu Ile Lys Lys Leu 

                725                 730                 735     





Gln Tyr Arg Tyr Glu Lys Phe Ser Pro Phe Ala Asp Thr Phe Lys Lys 

            740                 745                 750         





Arg Val Ser Lys Asn Thr Phe Phe Val Leu Val Arg Val Val Asp Glu 

        755                 760                 765             





Leu Cys Leu Val Glu Leu Thr Glu Glu Ile Leu Lys Leu Leu Met Glu 

    770                 775                 780                 





Leu Val Phe Arg Leu Val Cys Asn Gly Glu Leu Ser Leu Ala Arg Val 

785                 790                 795                 800 





Leu Arg Lys Asn Ile Leu Asp Lys Val Asp Gln Lys Lys Leu Leu Arg 

                805                 810                 815     





Cys Ala Thr Ser Ser Gln Pro Leu Ala Ala Arg Gly Val Ala Ala Arg 

            820                 825                 830         





Pro Gly Thr Leu His Asp Phe His Ser His Glu Ile Ala Glu Gln Leu 

        835                 840                 845             





Thr Leu Leu Asp Ala Glu Leu Phe Tyr Lys Ile Glu Ile Pro Glu Val 

    850                 855                 860                 





Leu Leu Trp Ala Lys Glu Gln Asn Glu Glu Lys Ser Pro Asn Leu Thr 

865                 870                 875                 880 





Gln Phe Thr Glu His Phe Asn Asn Met Ser Tyr Trp Val Arg Ser Ile 

                885                 890                 895     





Ile Met Leu Gln Glu Lys Ala Gln Asp Arg Glu Arg Leu Leu Leu Lys 

            900                 905                 910         





Phe Ile Lys Ile Met Lys His Leu Arg Lys Leu Asn Asn Phe Asn Ser 

        915                 920                 925             





Tyr Leu Ala Ile Leu Ser Ala Leu Asp Ser Ala Pro Ile Arg Arg Leu 

    930                 935                 940                 





Glu Trp Gln Lys Gln Thr Ser Glu Gly Leu Ala Glu Tyr Cys Thr Leu 

945                 950                 955                 960 





Ile Asp Ser Ser Ser Ser Phe Arg Ala Tyr Arg Ala Ala Leu Ser Glu 

                965                 970                 975     





Val Glu Pro Pro Cys Ile Pro Tyr Leu Gly Leu Ile Leu Gln Asp Leu 

            980                 985                 990         





Thr Phe Val His Leu Gly Asn Pro  Asp Tyr Ile Asp Gly  Lys Val Asn 

        995                 1000                 1005             





Phe Ser  Lys Arg Trp Gln Gln  Phe Asn Ile Leu Asp  Ser Met Arg 

    1010                 1015                 1020             





Cys Phe  Gln Gln Ala His Tyr  Asp Met Arg Arg Asn  Asp Asp Ile 

    1025                 1030                 1035             





Ile Asn  Phe Phe Asn Asp Phe  Ser Asp His Leu Ala  Glu Glu Ala 

    1040                 1045                 1050             





Leu Trp  Glu Leu Ser Leu Lys  Ile Lys Pro Arg Asn  Ile Thr Arg 

    1055                 1060                 1065             





Arg Lys  Thr Asp Arg Glu Glu  Lys Thr 

    1070                 1075         





<210>  268

<211>  6204

<212>  DNA

<213>  Homo sapiens



<400>  268

gagattcctc aggcttccct tgtgaggctg cctgggttct gccgctgggt ggtttgggat       60



gtccaagaga tatccccttt cagccagtga ctcggtcctc agttgctgct ccggaaagac      120



gctggggctg ggaagggccc tgtgtcctct ggctttaaaa tgggcaatgc tattgaaaaa      180



cagaagccct tgaaacgaag tcatctgtac ccctggaaac aagactctca gcgttctcat      240



ctctcttcct tcaccatgaa gctgatggac aaattccact cacccaaaat caagagaacg      300



ccatcaaaga agggaaaacc agctgaggtg tccgtaaaga ttccagagaa gcctgtgaac      360



aaagaggcaa cagacagatt tctaccagag ggctaccctc tccccttgga tctggagcag      420



caggcagtag aatttatgtc caccagtgct gtggcttcca ggtctcaaag gcagaagaac      480



ctgagctggc tggaggagaa agagaaggaa gttgtcagtg ccctgcgcta ctttaagacc      540



attgtggaca aaatggcaat tgataagaag gtactggaga tgcttccagg gtcagccagc      600



aaggtgctgg aggccatctt acccctggtg cagaacgatc ctcgaattca gcacagctca      660



gccctctctt cctgctatag ccgagtgtac caaagcctcg ccaacctcat tcgctggtct      720



gaccaagtga tgctggaagg cgtgaactca gaagacaagg agatggtgac gactgtgaag      780



ggggtcatca aggctgtgct ggatggagtg aaggagctgg tcaggctcac catcgagaag      840



cagggacgtc cgtctccgac gagccccgtg aagcccagtt cccctgccag caagcctgat      900



ggcccagcag agctccccct gacagaccgc gaggtagaga tcctaaacaa gacgactggg      960



atgtcacagt caactgagct cctcccagat gccacggatg aagaggtcgc gccccccaag     1020



cctcctctgc ctggcattcg ggtggttgat aatagtcctc caccagcatt gccacccaag     1080



aaaagacagt cggcgccgtc ccctacccga gtggctgtgg tggcccccat gagccgagcc     1140



accagtggct ccagtttgcc tgttggaatc aataggcagg attttgatgt tgactgttac     1200



gcacagaggc gactgtcagg aggcagccac tcatatggtg gagagtcgcc ccgcctctcc     1260



ccctgcagca gcataggcaa gctcagcaag tcagacgagc agctgtcctc tctggacagg     1320



gacagtgggc agtgctcccg gaacacaagc tgtgaaacac tagaccacta tgatcccgac     1380



tatgaattcc tccagcaaga cctctctaac gcagaccaga tacctcagca gacggcctgg     1440



aaccttagcc cgttgccaga gtctttgggg gagtctgggt ctccatttct tggccctcct     1500



ttccagctgc ctcttggcgg ccatccccag ccagacggac ctctggcccc agggcagcag     1560



acagatacgc cacctgctct ccccgagaag aagcgcagga gcgcagcctc ccagacggcg     1620



gacggctctg gctgcagggt gtcctacgag cggcatccct cgcagtatga caacatctct     1680



ggggaggacc tgcagagcac agccccgatc ccatccgtcc cctacgcgcc ctttgctgct     1740



attctgccct ttcagcatgg aggttcctca gcccctgtcg aatttgtggg tgattttact     1800



gctcctgagt caaccggtga cccagaaaaa ccacctcctc taccagagaa gaaaaacaaa     1860



cacatgctgg cctacatgca gttgctggag gactactcgg agccgcagcc ctctatgttc     1920



taccagacgc cacagaacga gcacatctac cagcagaaga acaagctcct catggaggta     1980



tacggcttca gcgactcctt cagtggggtg gactccgtgc aggagctggc cccgccgccc     2040



gccctacccc ccaagcagcg gcagctggag ccaccggctg ggaaagacgg acatcccaga     2100



gatccctcag cggtcagcgg cgtccctggg aaggacagca gagacggcag tgagagggcc     2160



ccaaagtcac cagatgctct ggagtcggct cagtcggagg aggaagtgga cgagctgtcc     2220



ctcattgacc acaacgaaat tatgtccagg ctgacgctca agcaggaggg tgatgacggg     2280



ccggacgtcc gcggaggatc tggggacatc ttactggtcc atgctactga gactgacagg     2340



aaagatttgg tgttgtactg cgaggcattc ctgaccacct acaggacctt catctcccca     2400



gaggagctca tcaagaagct gcagtacaga tatgagaaat tctctccctt tgccgacaca     2460



ttcaagaagc gcgtcagcaa gaacacgttc ttcgtgctgg tacgggtggt ggatgagctc     2520



tgcctggtgg agttgacaga agagatcctg aagctgctga tggaactggt cttccgcctg     2580



gtgtgcaatg gggagctgag cctggcccgt gtgctccgga agaacatcct ggacaaggtg     2640



gaccagaaga agctactcag gtgtgccacc tccagccagc ccctggcagc ccggggggta     2700



gcagccaggc cggggacctt gcacgacttt cacagccatg agatagcgga gcagctaacg     2760



ctgctggatg ctgagctctt ctataaaata gagattcctg aggttttgct ttgggcaaaa     2820



gagcagaatg aggagaagag ccccaacttg acccagttca cggagcactt caacaacatg     2880



tcctactggg tccggtccat aatcatgtta caggaaaagg cccaggacag ggaacggctg     2940



ctcttgaagt tcatcaagat catgaagcac ttgcggaagc tgaataactt caactcctac     3000



ttggccatcc tctctgccct ggactcggcg cccatccgca ggctggagtg gcagaagcag     3060



acttcagagg gcctggccga gtactgcaca ctgatcgaca gctcgtcctc cttccgagcc     3120



taccgggccg ccctctcgga ggtggaaccg ccgtgcatcc cgtacctggg gctgatcctg     3180



caggacctga ccttcgttca cctgggaaac ccagactaca tcgacgggaa agtgaacttc     3240



tccaagcggt ggcagcagtt caacatcctc gacagcatgc gctgcttcca gcaggcgcac     3300



tatgacatgc ggaggaacga cgacattata aacttcttca atgacttcag tgaccacctg     3360



gctgaggagg ccctatggga actgtctctg aaaattaaac ccaggaacat aacaaggaga     3420



aaaacagacc gggaagagaa gacctaggag cagacgccgg gatccaggag aatgctcgag     3480



gggcgcagag ggcagctccc agaccggaga ggaccttgga cctgttaggc gcatggcagg     3540



agtcccggcc tcggagccat gaggctggcc agccctcagc ggggccgggc gggagctgga     3600



gcctgccagc cgcttcctgc ctccttcctc tgtgggagca gacccgtggg cctcagggca     3660



gccagcaggc aggtcttgtt gccaatttac aaaccggtgg ttttctggtt tggttttgtt     3720



ttctgctttt acttccatct ctcccctctt gaccttccac ccactcccct ccagggagag     3780



agcagcagag acctcatcag cagaccaagg aagtggtggg tgctccccct ccctaagctc     3840



cagggtccct gaatcttctg aaatctcaaa tgagtggagg cctcctgggg tggcctgtcc     3900



tgcaggggcc ctggaatggg ggcaagcagc tgggtgggca gaatgcagag tagactcggg     3960



ggaggatcct ttcactttcc gcttcccctt ctgatgcatg gaggatggtg tgagcttttc     4020



agcaggcccg gaaaggtacg caggtgacgc cttagcagcc ccgcagctgg tgctctgccc     4080



cgcggtactg gcgccatcag ggcctccctt gcccgcctga gagcagcagc agtctctgtc     4140



atcccgtcgc cccttacccc ccaccccagg ccactgggcc cctcccacac cacctgggga     4200



gctgagaaga ggaggctgga gtaagggagg acttgatcat ccaagaaata ctttttattg     4260



ctgggagtct tctgaacctc accaaactga ggccagagct gagctcctgg gggagttaat     4320



tcagagggga gaggccagca cctccctcct ccatcgctcg ctgtgtgcct taaactccat     4380



ctcatgtccc tccccatccc ctggctttcc ctccctcctt gccccatcct gggccagcca     4440



gcagggctcc tcctctggct cttcagacct ttcagccagt gctgtcagtg cccctgggag     4500



ggaagggcat ccctgaggca cccgaatggt ccctcagggt gcagggaggc agaagcctgg     4560



ccacagagga gcctcctaag gcagcagctg cagcaagcgc accctctccc cactctcccc     4620



acgccagagc ggcttccaga gcagatgctg tttccatcct cctcgtcaaa accattctcg     4680



ctgctgagct tgacaatctg ggcaaggctt gtggggcgct tgacaaacag aatctgccct     4740



gtgccgcctg gttccgtggc ctccagcatg agcctgcagg cagggcgctg cgggaaccca     4800



gttgtgctgc cccagcccat gcctccgggt ctgctgtgca tgaatgagtg ctcacttgtc     4860



ccgggtttag gacgtggtca agtgaacagc agggtctaac tgtgcttact tagcccagtt     4920



caaacagaac aaaggaaaaa tatagaaagc aacatctgtt gatcatttag gttttttttt     4980



aaaccaccat gtcactttga gtccttcatg ggtttttgaa cagcatttat caagaagaaa     5040



atgtgggctt tttcccctct cccgtgtttt gtttgtcctg tagatagagg gaggaaagcc     5100



gtgcagtggc aggcgggacc ccctctggtg gcgggacccc ctcttgcggt ggtcttgcgg     5160



ggccagccgg gacctgtcac tttattattt aaggagtgtg tgtgtagagt cgctggctta     5220



ttaacagtat tgtgtgtggg ttgggttttt agtttgttcc ttctttttga agtcccttca     5280



tttcaatcct tgactctctc tccccttccc ttgcccagct ctgttgaatg ctgctgtgcg     5340



cgtgtgaggg ccgctctgca cacagggccc ttgggttgtg tgaactgaaa ttctccctgt     5400



atttgtgaga ctcgcaggag tccccatctg tagcacaggc aatgccagtg ccatgctgca     5460



gcctcagaaa ccaggcctct cactccagca gcaggcagaa ccgtgtctgt ggtcgggtgc     5520



tgtccacagc tctgtctgcc ttgttcttgg gcttgagctg gatagaggtg gggtctcttc     5580



accttccctg aattcagaac agaccctgtg cctggcccca gtgtgcccag gcaattcccc     5640



aggccctcac tgggagccct tggtgttctg agcagcaggg cccaggcagc acatgagcag     5700



tgcccagggg ctccctgcgt gaggacggca aggtgcgatg tatgtctaac ttattgatgg     5760



caggcagccc cctgtgcccc ctaagcctgg ccctggttat tgctgagctc tgtgctcagt     5820



gctgcggcct ggccgtggct cgtctgttcc tttggggggc ccgggcgggt tgtgggaatc     5880



agtcttcaca gacagacgtg agccaggcgg aggactcgtt ccttgcagag gtcagtcctc     5940



acctgcaggt gtcggggtgg gggggggcaa ggaggggcag gcacacacca tgtctgacct     6000



gaacccgatt ctggggagca tcttcccgct ccggccccac gacctccaca gggttacatt     6060



gtaatatata tgccccagct aacctgtctg atggtggcat cttcctgcag acatttcaaa     6120



catgtaactt ttatatgaaa aaaaataaac acagatgaaa gctgcccaat gccaaaaaaa     6180



aaaaaaaaaa aaaaaaaaaa aaaa                                            6204





<210>  269

<211>  1095

<212>  PRT

<213>  Homo sapiens



<400>  269



Met Gly Asn Ala Ile Glu Lys Gln Lys Pro Leu Lys Arg Ser His Leu 

1               5                   10                  15      





Tyr Pro Trp Lys Gln Asp Ser Gln Arg Ser His Leu Ser Ser Phe Thr 

            20                  25                  30          





Met Lys Leu Met Asp Lys Phe His Ser Pro Lys Ile Lys Arg Thr Pro 

        35                  40                  45              





Ser Lys Lys Gly Lys Pro Ala Glu Val Ser Val Lys Ile Pro Glu Lys 

    50                  55                  60                  





Pro Val Asn Lys Glu Ala Thr Asp Arg Phe Leu Pro Glu Gly Tyr Pro 

65                  70                  75                  80  





Leu Pro Leu Asp Leu Glu Gln Gln Ala Val Glu Phe Met Ser Thr Ser 

                85                  90                  95      





Ala Val Ala Ser Arg Ser Gln Arg Gln Lys Asn Leu Ser Trp Leu Glu 

            100                 105                 110         





Glu Lys Glu Lys Glu Val Val Ser Ala Leu Arg Tyr Phe Lys Thr Ile 

        115                 120                 125             





Val Asp Lys Met Ala Ile Asp Lys Lys Val Leu Glu Met Leu Pro Gly 

    130                 135                 140                 





Ser Ala Ser Lys Val Leu Glu Ala Ile Leu Pro Leu Val Gln Asn Asp 

145                 150                 155                 160 





Pro Arg Ile Gln His Ser Ser Ala Leu Ser Ser Cys Tyr Ser Arg Val 

                165                 170                 175     





Tyr Gln Ser Leu Ala Asn Leu Ile Arg Trp Ser Asp Gln Val Met Leu 

            180                 185                 190         





Glu Gly Val Asn Ser Glu Asp Lys Glu Met Val Thr Thr Val Lys Gly 

        195                 200                 205             





Val Ile Lys Ala Val Leu Asp Gly Val Lys Glu Leu Val Arg Leu Thr 

    210                 215                 220                 





Ile Glu Lys Gln Gly Arg Pro Ser Pro Thr Ser Pro Val Lys Pro Ser 

225                 230                 235                 240 





Ser Pro Ala Ser Lys Pro Asp Gly Pro Ala Glu Leu Pro Leu Thr Asp 

                245                 250                 255     





Arg Glu Val Glu Ile Leu Asn Lys Thr Thr Gly Met Ser Gln Ser Thr 

            260                 265                 270         





Glu Leu Leu Pro Asp Ala Thr Asp Glu Glu Val Ala Pro Pro Lys Pro 

        275                 280                 285             





Pro Leu Pro Gly Ile Arg Val Val Asp Asn Ser Pro Pro Pro Ala Leu 

    290                 295                 300                 





Pro Pro Lys Lys Arg Gln Ser Ala Pro Ser Pro Thr Arg Val Ala Val 

305                 310                 315                 320 





Val Ala Pro Met Ser Arg Ala Thr Ser Gly Ser Ser Leu Pro Val Gly 

                325                 330                 335     





Ile Asn Arg Gln Asp Phe Asp Val Asp Cys Tyr Ala Gln Arg Arg Leu 

            340                 345                 350         





Ser Gly Gly Ser His Ser Tyr Gly Gly Glu Ser Pro Arg Leu Ser Pro 

        355                 360                 365             





Cys Ser Ser Ile Gly Lys Leu Ser Lys Ser Asp Glu Gln Leu Ser Ser 

    370                 375                 380                 





Leu Asp Arg Asp Ser Gly Gln Cys Ser Arg Asn Thr Ser Cys Glu Thr 

385                 390                 395                 400 





Leu Asp His Tyr Asp Pro Asp Tyr Glu Phe Leu Gln Gln Asp Leu Ser 

                405                 410                 415     





Asn Ala Asp Gln Ile Pro Gln Gln Thr Ala Trp Asn Leu Ser Pro Leu 

            420                 425                 430         





Pro Glu Ser Leu Gly Glu Ser Gly Ser Pro Phe Leu Gly Pro Pro Phe 

        435                 440                 445             





Gln Leu Pro Leu Gly Gly His Pro Gln Pro Asp Gly Pro Leu Ala Pro 

    450                 455                 460                 





Gly Gln Gln Thr Asp Thr Pro Pro Ala Leu Pro Glu Lys Lys Arg Arg 

465                 470                 475                 480 





Ser Ala Ala Ser Gln Thr Ala Asp Gly Ser Gly Cys Arg Val Ser Tyr 

                485                 490                 495     





Glu Arg His Pro Ser Gln Tyr Asp Asn Ile Ser Gly Glu Asp Leu Gln 

            500                 505                 510         





Ser Thr Ala Pro Ile Pro Ser Val Pro Tyr Ala Pro Phe Ala Ala Ile 

        515                 520                 525             





Leu Pro Phe Gln His Gly Gly Ser Ser Ala Pro Val Glu Phe Val Gly 

    530                 535                 540                 





Asp Phe Thr Ala Pro Glu Ser Thr Gly Asp Pro Glu Lys Pro Pro Pro 

545                 550                 555                 560 





Leu Pro Glu Lys Lys Asn Lys His Met Leu Ala Tyr Met Gln Leu Leu 

                565                 570                 575     





Glu Asp Tyr Ser Glu Pro Gln Pro Ser Met Phe Tyr Gln Thr Pro Gln 

            580                 585                 590         





Asn Glu His Ile Tyr Gln Gln Lys Asn Lys Leu Leu Met Glu Val Tyr 

        595                 600                 605             





Gly Phe Ser Asp Ser Phe Ser Gly Val Asp Ser Val Gln Glu Leu Ala 

    610                 615                 620                 





Pro Pro Pro Ala Leu Pro Pro Lys Gln Arg Gln Leu Glu Pro Pro Ala 

625                 630                 635                 640 





Gly Lys Asp Gly His Pro Arg Asp Pro Ser Ala Val Ser Gly Val Pro 

                645                 650                 655     





Gly Lys Asp Ser Arg Asp Gly Ser Glu Arg Ala Pro Lys Ser Pro Asp 

            660                 665                 670         





Ala Leu Glu Ser Ala Gln Ser Glu Glu Glu Val Asp Glu Leu Ser Leu 

        675                 680                 685             





Ile Asp His Asn Glu Ile Met Ser Arg Leu Thr Leu Lys Gln Glu Gly 

    690                 695                 700                 





Asp Asp Gly Pro Asp Val Arg Gly Gly Ser Gly Asp Ile Leu Leu Val 

705                 710                 715                 720 





His Ala Thr Glu Thr Asp Arg Lys Asp Leu Val Leu Tyr Cys Glu Ala 

                725                 730                 735     





Phe Leu Thr Thr Tyr Arg Thr Phe Ile Ser Pro Glu Glu Leu Ile Lys 

            740                 745                 750         





Lys Leu Gln Tyr Arg Tyr Glu Lys Phe Ser Pro Phe Ala Asp Thr Phe 

        755                 760                 765             





Lys Lys Arg Val Ser Lys Asn Thr Phe Phe Val Leu Val Arg Val Val 

    770                 775                 780                 





Asp Glu Leu Cys Leu Val Glu Leu Thr Glu Glu Ile Leu Lys Leu Leu 

785                 790                 795                 800 





Met Glu Leu Val Phe Arg Leu Val Cys Asn Gly Glu Leu Ser Leu Ala 

                805                 810                 815     





Arg Val Leu Arg Lys Asn Ile Leu Asp Lys Val Asp Gln Lys Lys Leu 

            820                 825                 830         





Leu Arg Cys Ala Thr Ser Ser Gln Pro Leu Ala Ala Arg Gly Val Ala 

        835                 840                 845             





Ala Arg Pro Gly Thr Leu His Asp Phe His Ser His Glu Ile Ala Glu 

    850                 855                 860                 





Gln Leu Thr Leu Leu Asp Ala Glu Leu Phe Tyr Lys Ile Glu Ile Pro 

865                 870                 875                 880 





Glu Val Leu Leu Trp Ala Lys Glu Gln Asn Glu Glu Lys Ser Pro Asn 

                885                 890                 895     





Leu Thr Gln Phe Thr Glu His Phe Asn Asn Met Ser Tyr Trp Val Arg 

            900                 905                 910         





Ser Ile Ile Met Leu Gln Glu Lys Ala Gln Asp Arg Glu Arg Leu Leu 

        915                 920                 925             





Leu Lys Phe Ile Lys Ile Met Lys His Leu Arg Lys Leu Asn Asn Phe 

    930                 935                 940                 





Asn Ser Tyr Leu Ala Ile Leu Ser Ala Leu Asp Ser Ala Pro Ile Arg 

945                 950                 955                 960 





Arg Leu Glu Trp Gln Lys Gln Thr Ser Glu Gly Leu Ala Glu Tyr Cys 

                965                 970                 975     





Thr Leu Ile Asp Ser Ser Ser Ser Phe Arg Ala Tyr Arg Ala Ala Leu 

            980                 985                 990         





Ser Glu Val Glu Pro Pro Cys Ile  Pro Tyr Leu Gly Leu  Ile Leu Gln 

        995                 1000                 1005             





Asp Leu  Thr Phe Val His Leu  Gly Asn Pro Asp Tyr  Ile Asp Gly 

    1010                 1015                 1020             





Lys Val  Asn Phe Ser Lys Arg  Trp Gln Gln Phe Asn  Ile Leu Asp 

    1025                 1030                 1035             





Ser Met  Arg Cys Phe Gln Gln  Ala His Tyr Asp Met  Arg Arg Asn 

    1040                 1045                 1050             





Asp Asp  Ile Ile Asn Phe Phe  Asn Asp Phe Ser Asp  His Leu Ala 

    1055                 1060                 1065             





Glu Glu  Ala Leu Trp Glu Leu  Ser Leu Lys Ile Lys  Pro Arg Asn 

    1070                 1075                 1080             





Ile Thr  Arg Arg Lys Thr Asp  Arg Glu Glu Lys Thr  

    1085                 1090                 1095 





<210>  270

<211>  7182

<212>  DNA

<213>  Homo sapiens



<400>  270

ctttcctctt ggaagtggcg actgctgcgg ggctgagcgg tgctcgcacg cgtctcggga       60



gccaggttgg cggcgcgatg aggcgcagca aggccgatgt ggagcggtac gtcgcctcgg      120



tgctgggtct caccccgtcg cctcgacaga agtcaatgaa aggattctat tttgcaaagc      180



tgtattatga agctaaagaa tatgatcttg ctaaaaaata catatgtact tacattaatg      240



tgcaagagag ggatcccaaa gctcacagat ttctgggtct tctttatgaa ttggaagaaa      300



acacagagaa agccgttgaa tgttacaggc gttcagtgga attaaaccca acacaaaaag      360



atcttgtgtt gaagattgca gaattgcttt gtaaaaatga tgttactgat ggaagagcaa      420



aatactgggt cgaaagagca gcaaaacttt tcccaggaag tcctgcaatt tataaactaa      480



aggaacagct tctagattgt gaaggtgaag atggatggaa taaacttttt gacttgattc      540



agtcagaact ttatgtaaga cctgatgacg tccatgtgaa catccggcta gtggagttgt      600



atcgctcaac taaaagattg aaggatgctg tggcccactg ccatgaggca gagaggaaca      660



tagctttgcg ttcaagttta gagtggaatt cgtgtgttgt acagaccctt aaggaatatc      720



tggagtcttt acagtgtttg gagtctgata aaagtgactg gcaagcaacc aatacagact      780



tactgctggc ctatgctaat cttatgcttc ttacgctttc cactagagat gtgcaggaaa      840



atagagaatt actggaaagt tttgatagtg ctcttcagtc tgcgaaatct tctttgggtg      900



gaaatgatga actgtcagct actttcttag aaatgaaagg acatttctat atgtatgctg      960



gttctctgct cttgaagatg ggtcagcatg gtaataatgt tcaatggcga gctctttctg     1020



agctggctgc attgtgctat ctcatagcat ttcaggttcc aagaccaaag attaaattaa     1080



gagaaggtaa agctggacaa aatctgctgg aaatgatggc ctgtgaccga ctgagccaat     1140



cagggcacat gttgctaagc ttaagtcgtg gcaagcaaga tttcttaaaa gaggttgttg     1200



aaacttttgc caacaaaatt gggcagtctg cgttatatga tgctctgttt tctagtcagt     1260



cacctaagga tacatctttt cttggtagcg atgatattgg aaaaattgat gtacaagaac     1320



cagagcttga agatttggct agatacgatg ttggtgctat tcgagcacat aatggtagtc     1380



ttcagcatct tacttggctt ggcttacagt ggaattcatt gcctgcttta cctggaatcc     1440



gaaaatggct aaaacagctt ttccatcgtt tgccccatga aacctcaagg cttgaaacaa     1500



atgcgcctga atcaatatgt attttagatc ttgaagtatt tctccttgga gtagtatata     1560



ccagccactt acaattaaag gagaaatgta attctcacca tagctcctat cagccgttat     1620



gcctgccctt tcctgtgtgt aaacagcttt gtacagaaag acaaaaatct tggtgggatg     1680



cggtttgtac tctgattcac agaaaagcag tacctggaaa cttggcaaaa ttgagacttc     1740



tagttcagca tgaaataaac actctaagag cccaggaaaa acatggcctt caacctgctc     1800



tgcttgtaca ttgggcaaaa taccttcaga aaacgggcag cggtcttaat tctttttatg     1860



gtcaactaga atacataggg agaagtgttc attattggaa gaaagttttg ccattgttga     1920



agataataaa gaagaacagt attcctgaac ctattgatcc tctgtttaaa cattttcata     1980



gtgtagacat tcaggcatca gaaattgttg aatatgaaga agacgcacac ataacttttg     2040



ctatgttgga tgcagtaaat ggaaatatag aagatgctgt gactgctttt gaatctataa     2100



aaagtgttgt ttcttattgg aatcttgcac tgatttttca caggaaggca gaagacattg     2160



aaaatgatgc cctttctcct gaagaacaag aagaatgcag aaattatctg acaaagacca     2220



gggactacct aataaagatt atagatgacg gtgattcaaa tctttcagtg gtcaagaaat     2280



tgcctgtgcc cctggagtct gtaaaacaga tgcttaattc agtcatgcag gaactcgaag     2340



actatagtga aggaggtcct ctctataaaa atggttcttt gcgaaatgca gattcagaaa     2400



taaaacattc tacaccgtct cctaccaaat attcactatc accaagtaaa agttacaagt     2460



attctcccga aacaccacct cgatggacag aagatcggaa ttctttactg aatatgattt     2520



gccaacaagt agaggccatt aagaaagaaa tgcaggagtt gaaactaaat agcagtaagt     2580



cagcatcccg tcatcgttgg cccacagaga attatggacc agactcggtg cctgatggat     2640



atcaggggtc acagacattt catggggctc cactaacagt tgcaactact ggcccttcag     2700



tatattatag tcagtcacca gcatataatt cccagtatct tctcagacca gcagctaatg     2760



ttactcccac aaagggttct tctaatacag aatttaagtc aaccaaagaa ggattttcca     2820



tccctgtgtc tgctgatgga tttaaatttg gcatttcgga accaggaaat caagaaaaga     2880



aaagggaaaa gcctcttgaa aatgatactg gcttccaggc tcaggatatt agtggccgga     2940



agaagggccg tggtgtgatt tttggccaaa caagtagcac ttttacattt gcagatgttg     3000



caaaatcaac ttcaggagaa ggatttcagt ttggcaaaaa agacctcaat ttcaagggat     3060



tttcaggtgc tggagaaaaa ttattctcat cacgatacgg taaaatggcc aataaagcaa     3120



acacttccgg tgactttgag aaagatgatg atgcctataa gactgaggac agcgatgaca     3180



tccattttga accagtagtt caaatgcctg aaaaagtaga acttgtaaca ggagaagaag     3240



gtgaaaaagt tctgtattca cagggggtaa aactatttag atttgatgct gaggtaaggc     3300



agtggaaaga aaggggcttg gggaacttaa aaattctcaa aaacgaggtc aatggcaaac     3360



taagaatgct gatgcgaaga gaacaagtac taaaagtgtg tgctaatcat tggataacga     3420



ctacaatgaa cctgaagccc ctctctggat cagatagagc atggatgtgg tcagccagtg     3480



atttctctga cggtgatgcc aaactagagc ggttggcagc aaaatttaaa acaccagagc     3540



tggctgaaga attcaagcag aaatttgagg aatgccagcg gcttctgtta gacataccac     3600



ttcaaactcc ccataaactt gtagatactg gcagagctgc caagttaata cagagagctg     3660



aagaaatgaa gagtggactg aaagatttca aaacattttt gacaaatgat caaacaaaag     3720



tcactgagga agaaaataag ggttcaggta caggtgcggc cggtgcctca gacacaacaa     3780



taaaacccaa tgctgaaaac actgggccca cattagaatg ggataactat gacttaaggg     3840



aagatgcttt ggatgatagt gtcagtagta gctcagtaca tgcttctcca ttggcaagta     3900



gccctgtgag aaaaaatctt ttccgctttg atgagtcaac aacaggatct aacttcagtt     3960



ttaaatctgc tttgagtcta tctaagtctc ctgccaagtt gaatcagagt gggacttcag     4020



ttggcactga tgaagaatct gttgttactc aagaagaaga gagagatgga cagtactttg     4080



aacctgttgt tcctttacct gatctagttg aagtatccag tggtgaggaa aatgaacaag     4140



ttgtttttag tcacagggca gaaatctaca gatatgataa agatgttggt caatggaaag     4200



aaaggggcat tggtgatata aagattttac agaattatga taataagcaa gttcgtatag     4260



tgatgagaag ggaccaagta ttaaaacttt gtgccaatca cagaataact ccagacatga     4320



gtttgcaaaa tatgaaaggg acagaaagag tatgggtgtg gactgcatgt gattttgcag     4380



atggagaaag aaaagtagag catttagctg ttcgttttaa actacaggat gttgcagact     4440



cgtttaagaa aatttttgat gaagcaaaaa cagcccagga aaaagattct ttgataacac     4500



ctcatgtttc tcggtcaagc actcccagag agtcaccatg tggcaaaatt gctgtagcta     4560



tattagaaga aaccacaaga gagaggacag atgttattca gggtgatgat gtagcagatg     4620



cagcttcaga agttgaagtg tctagcacat ctgaaacaac aacaaaagca gtggtttctc     4680



ctccaaagtt tgtatttgtt tcagagtctg ttaaaagaat ttttagtagt gaaaaatcaa     4740



aaccatttgt atttggcaac agttctgcca ctgggtcttt gtttggattt agttttaatg     4800



cacctttgaa aagtaacaat agtgaaacta gttcagtagc ccagagtgga tctgaaagca     4860



aagtggaacc taaaaaatgt gaactgtcaa agaactctga tatcgaacag tcttcagata     4920



gcaaagtcaa aaatctctct gcttcctttc caacggaaga atcttcaatc aactacacat     4980



ttaaaacacc agaaaaggag cctccattat ggcatgctga atttaccaaa gaagaattgg     5040



ttcagaagct ccgttccacc acaaaaagtg cagatcactt aaacggcctg cttcgggaaa     5100



tagaggcaac caatgcagtc cttatggagc aaattaagct tctcaaaagt gaaataagaa     5160



gattggaaag gaatcaagag cgagagaagt ctgcagctaa cctggaatac ttgaagaacg     5220



tcttgctgca gttcattttc ttgaagccag gtagtgaaag agagagactt cttcctgtta     5280



taaatacgat gttgcagctc agccctgaag aaaagggaaa acttgctgcg gttgctcaag     5340



atgaggaaga aaatgcttcc cgttcttctg gatgagcatc ctatcttcgt agttggtttg     5400



gacttcgata ggttgatgga aggaatactt ctattaacca aatagaatct gtttacaaaa     5460



atggttcgtg tgtgttacca ttattctttt gtcaaaaagt gtgtatatat gtttgcattt     5520



acatatattt gtacatctgt atgacagatg tattttaaaa gtttcaactt gaagtaaaag     5580



tacaacagct tgaagtgttg ataccaggcc acagccctct aactcatgtg atctcccatg     5640



catgctgcca gaataaaacc accaggaatg aattcactcc ccacttctct ggaacctcag     5700



gacccgccca tttctcggca gtactgtgaa ttttgaagtt aaactaaatt ttggtaccat     5760



accaactgga atttaggctt taaaaataat gtttcaaggc caggtgtggt gattcatgcc     5820



tgaaatccca ctactttggg aggctgaggc tggagaatcg cttgaggcta gtgagctgtg     5880



attgtaccac tgcactccag ctcggggaac agagcgagac cttgtctcta aaaataataa     5940



tagtaataaa aataacgttt tatgactatt tattgcaagg tcagatttac agattgttat     6000



aaattgttga gaaatttttg tgattagaat atgaaggaaa aagctttgtt ggtaaaagtg     6060



acatgttaag gggctatgaa gtaaatatgc tgcagttaat tgtgctaagt taaaatacag     6120



tttagttatt tgctttaaaa taaactcttc tttttttctt taaagtatac tacctcaaaa     6180



ctcattatgt tgtcagagcc ctagagctgg ctagtgtaac actgactatg agtaggtggg     6240



cccaccactt gagttgaggt gatttcatgg tgtctttcca ggctcttgat agggtgtcac     6300



tgcatgcaag ccatgaatct gttttgagaa tcctctccat tttcccaaat aaaaacctat     6360



cccaacagtg actatatcac tcagcattgg atctaaatat aaaagtggtg ctttcagtgt     6420



ttttggcaga tagtgttcca taacctttcc atcagaaggg attttagaca ccttagaggt     6480



ccgtgctaca tcttcacagt tcctccgaat aaccttaggt ggtagtgtta cttgcctttg     6540



acacctgtgc atatgtttta atgactagat ccaaactgtg ttgttcttaa atcaaaaatt     6600



ggataatttt taatatttat gtattaatca cacagtgtgc tctctgaagt tctcttaagc     6660



cttcagttta tactcttaat tttctttctg agctggggaa ctgactttgc actttggtta     6720



cacagaacat tggtttccaa tttagtttaa ctgaaatttg ctgctgatat gttgagtttg     6780



ttctttaaaa aatatctcat atatctcgtc tttcctcctt agaagaacag acctaactag     6840



cgaatgtatg aatgaaaatg catctatttc agagccgaca tgaagagttt agttttttta     6900



ctttataaac tgtgaatatg agtatgccag ctgcattaga tgtaactaat catatttaaa     6960



tatatttcac tttgacttta gaccttttga agtctgtata aacttgtttt gaaatacagt     7020



ctccacttac gaatgtcata acaaaatact tttttgcatg ataaaaaatt actttgatta     7080



caaaaggcat attctttcat ggtttctgca atgagaggaa gtgtaatgat tattttaata     7140



tttctattaa aactgtatat ttttaaaaaa aaaaaaaaaa aa                        7182





<210>  271

<211>  1765

<212>  PRT

<213>  Homo sapiens



<400>  271



Met Arg Arg Ser Lys Ala Asp Val Glu Arg Tyr Val Ala Ser Val Leu 

1               5                   10                  15      





Gly Leu Thr Pro Ser Pro Arg Gln Lys Ser Met Lys Gly Phe Tyr Phe 

            20                  25                  30          





Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 

        35                  40                  45              





Ile Cys Thr Tyr Ile Asn Val Gln Glu Arg Asp Pro Lys Ala His Arg 

    50                  55                  60                  





Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Glu Lys Ala Val 

65                  70                  75                  80  





Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 

                85                  90                  95      





Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 

            100                 105                 110         





Arg Ala Lys Tyr Trp Val Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 

        115                 120                 125             





Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 

    130                 135                 140                 





Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 

145                 150                 155                 160 





Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Leu Tyr Arg 

                165                 170                 175     





Ser Thr Lys Arg Leu Lys Asp Ala Val Ala His Cys His Glu Ala Glu 

            180                 185                 190         





Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 

        195                 200                 205             





Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 

    210                 215                 220                 





Lys Ser Asp Trp Gln Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 

225                 230                 235                 240 





Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Asn Arg 

                245                 250                 255     





Glu Leu Leu Glu Ser Phe Asp Ser Ala Leu Gln Ser Ala Lys Ser Ser 

            260                 265                 270         





Leu Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly 

        275                 280                 285             





His Phe Tyr Met Tyr Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His 

    290                 295                 300                 





Gly Asn Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys 

305                 310                 315                 320 





Tyr Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Arg Glu 

                325                 330                 335     





Gly Lys Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu 

            340                 345                 350         





Ser Gln Ser Gly His Met Leu Leu Ser Leu Ser Arg Gly Lys Gln Asp 

        355                 360                 365             





Phe Leu Lys Glu Val Val Glu Thr Phe Ala Asn Lys Ile Gly Gln Ser 

    370                 375                 380                 





Ala Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser 

385                 390                 395                 400 





Phe Leu Gly Ser Asp Asp Ile Gly Lys Ile Asp Val Gln Glu Pro Glu 

                405                 410                 415     





Leu Glu Asp Leu Ala Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn 

            420                 425                 430         





Gly Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu 

        435                 440                 445             





Pro Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His Arg 

    450                 455                 460                 





Leu Pro His Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile 

465                 470                 475                 480 





Cys Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser 

                485                 490                 495     





His Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln 

            500                 505                 510         





Pro Leu Cys Leu Pro Phe Pro Val Cys Lys Gln Leu Cys Thr Glu Arg 

        515                 520                 525             





Gln Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala 

    530                 535                 540                 





Val Pro Gly Asn Leu Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile 

545                 550                 555                 560 





Asn Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu 

                565                 570                 575     





Val His Trp Ala Lys Tyr Leu Gln Lys Thr Gly Ser Gly Leu Asn Ser 

            580                 585                 590         





Phe Tyr Gly Gln Leu Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys 

        595                 600                 605             





Lys Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Asn Ser Ile Pro Glu 

    610                 615                 620                 





Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln Ala 

625                 630                 635                 640 





Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Ile Thr Phe Ala Met 

                645                 650                 655     





Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Val Thr Ala Phe Glu 

            660                 665                 670         





Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe His 

        675                 680                 685             





Arg Lys Ala Glu Asp Ile Glu Asn Asp Ala Leu Ser Pro Glu Glu Gln 

    690                 695                 700                 





Glu Glu Cys Arg Asn Tyr Leu Thr Lys Thr Arg Asp Tyr Leu Ile Lys 

705                 710                 715                 720 





Ile Ile Asp Asp Gly Asp Ser Asn Leu Ser Val Val Lys Lys Leu Pro 

                725                 730                 735     





Val Pro Leu Glu Ser Val Lys Gln Met Leu Asn Ser Val Met Gln Glu 

            740                 745                 750         





Leu Glu Asp Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser Leu 

        755                 760                 765             





Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr Lys 

    770                 775                 780                 





Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Glu Thr Pro 

785                 790                 795                 800 





Pro Arg Trp Thr Glu Asp Arg Asn Ser Leu Leu Asn Met Ile Cys Gln 

                805                 810                 815     





Gln Val Glu Ala Ile Lys Lys Glu Met Gln Glu Leu Lys Leu Asn Ser 

            820                 825                 830         





Ser Lys Ser Ala Ser Arg His Arg Trp Pro Thr Glu Asn Tyr Gly Pro 

        835                 840                 845             





Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly Ala 

    850                 855                 860                 





Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln Ser 

865                 870                 875                 880 





Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val Thr 

                885                 890                 895     





Pro Thr Lys Gly Ser Ser Asn Thr Glu Phe Lys Ser Thr Lys Glu Gly 

            900                 905                 910         





Phe Ser Ile Pro Val Ser Ala Asp Gly Phe Lys Phe Gly Ile Ser Glu 

        915                 920                 925             





Pro Gly Asn Gln Glu Lys Lys Arg Glu Lys Pro Leu Glu Asn Asp Thr 

    930                 935                 940                 





Gly Phe Gln Ala Gln Asp Ile Ser Gly Arg Lys Lys Gly Arg Gly Val 

945                 950                 955                 960 





Ile Phe Gly Gln Thr Ser Ser Thr Phe Thr Phe Ala Asp Val Ala Lys 

                965                 970                 975     





Ser Thr Ser Gly Glu Gly Phe Gln Phe Gly Lys Lys Asp Leu Asn Phe 

            980                 985                 990         





Lys Gly Phe Ser Gly Ala Gly Glu  Lys Leu Phe Ser Ser  Arg Tyr Gly 

        995                 1000                 1005             





Lys Met  Ala Asn Lys Ala Asn  Thr Ser Gly Asp Phe  Glu Lys Asp 

    1010                 1015                 1020             





Asp Asp  Ala Tyr Lys Thr Glu  Asp Ser Asp Asp Ile  His Phe Glu 

    1025                 1030                 1035             





Pro Val  Val Gln Met Pro Glu  Lys Val Glu Leu Val  Thr Gly Glu 

    1040                 1045                 1050             





Glu Gly  Glu Lys Val Leu Tyr  Ser Gln Gly Val Lys  Leu Phe Arg 

    1055                 1060                 1065             





Phe Asp  Ala Glu Val Arg Gln  Trp Lys Glu Arg Gly  Leu Gly Asn 

    1070                 1075                 1080             





Leu Lys  Ile Leu Lys Asn Glu  Val Asn Gly Lys Leu  Arg Met Leu 

    1085                 1090                 1095             





Met Arg  Arg Glu Gln Val Leu  Lys Val Cys Ala Asn  His Trp Ile 

    1100                 1105                 1110             





Thr Thr  Thr Met Asn Leu Lys  Pro Leu Ser Gly Ser  Asp Arg Ala 

    1115                 1120                 1125             





Trp Met  Trp Ser Ala Ser Asp  Phe Ser Asp Gly Asp  Ala Lys Leu 

    1130                 1135                 1140             





Glu Arg  Leu Ala Ala Lys Phe  Lys Thr Pro Glu Leu  Ala Glu Glu 

    1145                 1150                 1155             





Phe Lys  Gln Lys Phe Glu Glu  Cys Gln Arg Leu Leu  Leu Asp Ile 

    1160                 1165                 1170             





Pro Leu  Gln Thr Pro His Lys  Leu Val Asp Thr Gly  Arg Ala Ala 

    1175                 1180                 1185             





Lys Leu  Ile Gln Arg Ala Glu  Glu Met Lys Ser Gly  Leu Lys Asp 

    1190                 1195                 1200             





Phe Lys  Thr Phe Leu Thr Asn  Asp Gln Thr Lys Val  Thr Glu Glu 

    1205                 1210                 1215             





Glu Asn  Lys Gly Ser Gly Thr  Gly Ala Ala Gly Ala  Ser Asp Thr 

    1220                 1225                 1230             





Thr Ile  Lys Pro Asn Ala Glu  Asn Thr Gly Pro Thr  Leu Glu Trp 

    1235                 1240                 1245             





Asp Asn  Tyr Asp Leu Arg Glu  Asp Ala Leu Asp Asp  Ser Val Ser 

    1250                 1255                 1260             





Ser Ser  Ser Val His Ala Ser  Pro Leu Ala Ser Ser  Pro Val Arg 

    1265                 1270                 1275             





Lys Asn  Leu Phe Arg Phe Asp  Glu Ser Thr Thr Gly  Ser Asn Phe 

    1280                 1285                 1290             





Ser Phe  Lys Ser Ala Leu Ser  Leu Ser Lys Ser Pro  Ala Lys Leu 

    1295                 1300                 1305             





Asn Gln  Ser Gly Thr Ser Val  Gly Thr Asp Glu Glu  Ser Val Val 

    1310                 1315                 1320             





Thr Gln  Glu Glu Glu Arg Asp  Gly Gln Tyr Phe Glu  Pro Val Val 

    1325                 1330                 1335             





Pro Leu  Pro Asp Leu Val Glu  Val Ser Ser Gly Glu  Glu Asn Glu 

    1340                 1345                 1350             





Gln Val  Val Phe Ser His Arg  Ala Glu Ile Tyr Arg  Tyr Asp Lys 

    1355                 1360                 1365             





Asp Val  Gly Gln Trp Lys Glu  Arg Gly Ile Gly Asp  Ile Lys Ile 

    1370                 1375                 1380             





Leu Gln  Asn Tyr Asp Asn Lys  Gln Val Arg Ile Val  Met Arg Arg 

    1385                 1390                 1395             





Asp Gln  Val Leu Lys Leu Cys  Ala Asn His Arg Ile  Thr Pro Asp 

    1400                 1405                 1410             





Met Ser  Leu Gln Asn Met Lys  Gly Thr Glu Arg Val  Trp Val Trp 

    1415                 1420                 1425             





Thr Ala  Cys Asp Phe Ala Asp  Gly Glu Arg Lys Val  Glu His Leu 

    1430                 1435                 1440             





Ala Val  Arg Phe Lys Leu Gln  Asp Val Ala Asp Ser  Phe Lys Lys 

    1445                 1450                 1455             





Ile Phe  Asp Glu Ala Lys Thr  Ala Gln Glu Lys Asp  Ser Leu Ile 

    1460                 1465                 1470             





Thr Pro  His Val Ser Arg Ser  Ser Thr Pro Arg Glu  Ser Pro Cys 

    1475                 1480                 1485             





Gly Lys  Ile Ala Val Ala Ile  Leu Glu Glu Thr Thr  Arg Glu Arg 

    1490                 1495                 1500             





Thr Asp  Val Ile Gln Gly Asp  Asp Val Ala Asp Ala  Ala Ser Glu 

    1505                 1510                 1515             





Val Glu  Val Ser Ser Thr Ser  Glu Thr Thr Thr Lys  Ala Val Val 

    1520                 1525                 1530             





Ser Pro  Pro Lys Phe Val Phe  Val Ser Glu Ser Val  Lys Arg Ile 

    1535                 1540                 1545             





Phe Ser  Ser Glu Lys Ser Lys  Pro Phe Val Phe Gly  Asn Ser Ser 

    1550                 1555                 1560             





Ala Thr  Gly Ser Leu Phe Gly  Phe Ser Phe Asn Ala  Pro Leu Lys 

    1565                 1570                 1575             





Ser Asn  Asn Ser Glu Thr Ser  Ser Val Ala Gln Ser  Gly Ser Glu 

    1580                 1585                 1590             





Ser Lys  Val Glu Pro Lys Lys  Cys Glu Leu Ser Lys  Asn Ser Asp 

    1595                 1600                 1605             





Ile Glu  Gln Ser Ser Asp Ser  Lys Val Lys Asn Leu  Ser Ala Ser 

    1610                 1615                 1620             





Phe Pro  Thr Glu Glu Ser Ser  Ile Asn Tyr Thr Phe  Lys Thr Pro 

    1625                 1630                 1635             





Glu Lys  Glu Pro Pro Leu Trp  His Ala Glu Phe Thr  Lys Glu Glu 

    1640                 1645                 1650             





Leu Val  Gln Lys Leu Arg Ser  Thr Thr Lys Ser Ala  Asp His Leu 

    1655                 1660                 1665             





Asn Gly  Leu Leu Arg Glu Ile  Glu Ala Thr Asn Ala  Val Leu Met 

    1670                 1675                 1680             





Glu Gln  Ile Lys Leu Leu Lys  Ser Glu Ile Arg Arg  Leu Glu Arg 

    1685                 1690                 1695             





Asn Gln  Glu Arg Glu Lys Ser  Ala Ala Asn Leu Glu  Tyr Leu Lys 

    1700                 1705                 1710             





Asn Val  Leu Leu Gln Phe Ile  Phe Leu Lys Pro Gly  Ser Glu Arg 

    1715                 1720                 1725             





Glu Arg  Leu Leu Pro Val Ile  Asn Thr Met Leu Gln  Leu Ser Pro 

    1730                 1735                 1740             





Glu Glu  Lys Gly Lys Leu Ala  Ala Val Ala Gln Asp  Glu Glu Glu 

    1745                 1750                 1755             





Asn Ala  Ser Arg Ser Ser Gly  

    1760                 1765 





<210>  272

<211>  3325

<212>  DNA

<213>  Homo sapiens



<400>  272

ataaacccca gggctcattc ttgagctgct cctgcataga tctcgtcctg ttcaacacac       60



caaagattga cagctgaact gagagaccat cacccacaga cacaactggc cactgggtgg      120



tgcacaagtc agacagaact gaatagtcct gtgaagactc tggacactga actgactttg      180



gaaccagact gcagaatgga ggggtgggaa cttgtggctt gaacctaatc aggtttcatt      240



aaggttttct atagataaga tcatgtcaag acaccctcag accacagggc ggcgccacga      300



gcccggccga gtgcagctgg agcgccgacg tcgccgagga tacacagtgc tgaggcagaa      360



cgcaggttcg tcacagtggg cctccgtggg cggcgccgca cgctcgtcac agtgggcctc      420



cgccggctac gccgctgctt cagtggcttg caggcacttt cctcttggaa gtggcgactg      480



ctgcggggct gagcggtgct cgcacgcgtc tcgggagcca ggttggcggc gcgatgaggc      540



gcagcaaggc cgatgtggag cggtacgtcg cctcggtgct gggtctcacc ccgtcgcctc      600



gacagaagtc aatgaaagga ttctattttg caaagctgta ttatgaagct aaagaatatg      660



atcttgctaa aaaatacata tgtacttaca ttaatgtgca agagagggat cccaaagctc      720



acagatttct gggtcttctt tatgaattgg aagaaaacac agagaaagcc gttgaatgtt      780



acaggcgttc agtggaatta aacccaacac aaaaagatct tgtgttgaag attgcagaat      840



tgctttgtaa aaatgatgtt actgatggaa gagcaaaata ctgggtcgaa agagcagcaa      900



aacttttccc aggaagtcct gcaatttata aactaaagga acagcttcta gattgtgaag      960



gtgaagatgg atggaataaa ctttttgact tgattcagtc agaactttat gtaagacctg     1020



atgacgtcca tgtgaacatc cggctagtgg agttgtatcg ctcaactaaa agattgaagg     1080



atgctgtggc ccactgccat gaggcagaga ggaacatagc tttgcgttca agtttagagt     1140



ggaattcgtg tgttgtacag acccttaagg aatatctgga gtctttacag tgtttggagt     1200



ctgataaaag tgactggcaa gcaaccaata cagacttact gctggcctat gctaatctta     1260



tgcttcttac gctttccact agagatgtgc aggaaaatag agaattactg gaaagttttg     1320



atagtgctct tcagtctgcg aaatcttctt tgggtggaaa tgatgaactg tcagctactt     1380



tcttagaaat gaaaggacat ttctatatgt atgctggttc tctgctcttg aagatgggtc     1440



agcatggtaa taatgttcaa tggcgagctc tttctgagct ggctgcattg tgctatctca     1500



tagcatttca ggttccaaga ccaaagatta aattaagaga aggtaaagct ggacaaaatc     1560



tgctggaaat gatggcctgt gaccgactga gccaatcagg gcacatgttg ctaagcttaa     1620



gtcgtggcaa gcaagatttc ttaaaagagg ttgttgaaac ttttgccaac aaaattgggc     1680



agtctgcgtt atatgatgct ctgttttcta gtcagtcacc taaggataca tcttttcttg     1740



gtagcgatga tattggaaaa attgatgtac aagaaccaga gcttgaagat ttggctagat     1800



acgatgttgg tgctattcga gcacataatg gtagtcttca gcatcttact tggcttggct     1860



tacagtggaa ttcattgcct gctttacctg gaatccgaaa atggctaaaa cagcttttcc     1920



atcgtttgcc ccatgaaacc tcaaggcttg aaacaaatgc gcctgaatca atatgtattt     1980



tagatcttga agtatttctc cttggagtag tatataccag ccacttacaa ttaaaggaga     2040



aatgtaattc tcaccatagc tcctatcagc cgttatgcct gccctttcct gtgtgtaaac     2100



agctttgtac agaaagacaa aaatcttggt gggatgcggt ttgtactctg attcacagaa     2160



aagcagtacc tggaaacttg gcaaaattga gacttctagt tcagcatgaa ataaacactc     2220



taagagccca ggaaaaacat ggccttcaac ctgctctgct tgtacattgg gcaaaatacc     2280



ttcagaaaac gggcagcggt cttaattctt tttatggtca actagaatac atagggagaa     2340



gtgttcatta ttggaagaaa gttttgccat tgttgaagat aataaagaag aacagtattc     2400



ctgaacctat tgatcctctg tttaaacatt ttcatagtgt agacattcag gcatcagaaa     2460



ttgttgaata tgaagaagac gcacacataa cttttgctat gttggatgca gtaaatggaa     2520



atatagaaga tgctgtgact gcttttgaat ctataaaaag tgttgtttct tattggaatc     2580



ttgcactgat ttttcacagg aaggcagaag acattgaaaa tgatgccctt tctcctgaag     2640



aacaagaaga atgcagaaat tatctgacaa agaccaggga ctacctaata aagattatag     2700



atgacggtga ttcaaatctt tcagtggtca agaaattgcc tgtgcccctg gagtctgtaa     2760



aacagatgct taattcagtc atgcaggaac tcgaagacta tagtgaagga ggtcctctct     2820



ataaaaatgg ttctttgcga aatgcagatt cagaaataaa acattctaca ccgtctccta     2880



ccaaatattc actatcacca agtaaaagtt acaagtattc tcccgaaaca ccacctcgat     2940



ggacagaaga tcggaattct ttactgaata tgatttgcca acaagtagag gccattaaga     3000



aagaaatgca ggagttgaaa ctaaatagca gtaagtcagc atcccgtcat cgttggccca     3060



cagagaatta tggaccagac tcggtgcctg atggatatca ggggtcacag acatttcatg     3120



gggctccact aacagaagca gcacatcgtc attttacaat tgagaaacat ggagactcca     3180



aatggattat ttacaggttc acaaaacagc tttgtggcac tgaaagggcg agagccaaga     3240



tctcctgatt tctgttcctg tgttcataga ttctttttcc ttaataaaag taaacatata     3300



tcaaaaaaaa aaaaaaaaaa aaaaa                                           3325





<210>  273

<211>  904

<212>  PRT

<213>  Homo sapiens



<400>  273



Met Arg Arg Ser Lys Ala Asp Val Glu Arg Tyr Val Ala Ser Val Leu 

1               5                   10                  15      





Gly Leu Thr Pro Ser Pro Arg Gln Lys Ser Met Lys Gly Phe Tyr Phe 

            20                  25                  30          





Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 

        35                  40                  45              





Ile Cys Thr Tyr Ile Asn Val Gln Glu Arg Asp Pro Lys Ala His Arg 

    50                  55                  60                  





Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Glu Lys Ala Val 

65                  70                  75                  80  





Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 

                85                  90                  95      





Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 

            100                 105                 110         





Arg Ala Lys Tyr Trp Val Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 

        115                 120                 125             





Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 

    130                 135                 140                 





Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 

145                 150                 155                 160 





Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Leu Tyr Arg 

                165                 170                 175     





Ser Thr Lys Arg Leu Lys Asp Ala Val Ala His Cys His Glu Ala Glu 

            180                 185                 190         





Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 

        195                 200                 205             





Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 

    210                 215                 220                 





Lys Ser Asp Trp Gln Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 

225                 230                 235                 240 





Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Asn Arg 

                245                 250                 255     





Glu Leu Leu Glu Ser Phe Asp Ser Ala Leu Gln Ser Ala Lys Ser Ser 

            260                 265                 270         





Leu Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly 

        275                 280                 285             





His Phe Tyr Met Tyr Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His 

    290                 295                 300                 





Gly Asn Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys 

305                 310                 315                 320 





Tyr Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Arg Glu 

                325                 330                 335     





Gly Lys Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu 

            340                 345                 350         





Ser Gln Ser Gly His Met Leu Leu Ser Leu Ser Arg Gly Lys Gln Asp 

        355                 360                 365             





Phe Leu Lys Glu Val Val Glu Thr Phe Ala Asn Lys Ile Gly Gln Ser 

    370                 375                 380                 





Ala Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser 

385                 390                 395                 400 





Phe Leu Gly Ser Asp Asp Ile Gly Lys Ile Asp Val Gln Glu Pro Glu 

                405                 410                 415     





Leu Glu Asp Leu Ala Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn 

            420                 425                 430         





Gly Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu 

        435                 440                 445             





Pro Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His Arg 

    450                 455                 460                 





Leu Pro His Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile 

465                 470                 475                 480 





Cys Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser 

                485                 490                 495     





His Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln 

            500                 505                 510         





Pro Leu Cys Leu Pro Phe Pro Val Cys Lys Gln Leu Cys Thr Glu Arg 

        515                 520                 525             





Gln Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala 

    530                 535                 540                 





Val Pro Gly Asn Leu Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile 

545                 550                 555                 560 





Asn Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu 

                565                 570                 575     





Val His Trp Ala Lys Tyr Leu Gln Lys Thr Gly Ser Gly Leu Asn Ser 

            580                 585                 590         





Phe Tyr Gly Gln Leu Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys 

        595                 600                 605             





Lys Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Asn Ser Ile Pro Glu 

    610                 615                 620                 





Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln Ala 

625                 630                 635                 640 





Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Ile Thr Phe Ala Met 

                645                 650                 655     





Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Val Thr Ala Phe Glu 

            660                 665                 670         





Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe His 

        675                 680                 685             





Arg Lys Ala Glu Asp Ile Glu Asn Asp Ala Leu Ser Pro Glu Glu Gln 

    690                 695                 700                 





Glu Glu Cys Arg Asn Tyr Leu Thr Lys Thr Arg Asp Tyr Leu Ile Lys 

705                 710                 715                 720 





Ile Ile Asp Asp Gly Asp Ser Asn Leu Ser Val Val Lys Lys Leu Pro 

                725                 730                 735     





Val Pro Leu Glu Ser Val Lys Gln Met Leu Asn Ser Val Met Gln Glu 

            740                 745                 750         





Leu Glu Asp Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser Leu 

        755                 760                 765             





Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr Lys 

    770                 775                 780                 





Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Glu Thr Pro 

785                 790                 795                 800 





Pro Arg Trp Thr Glu Asp Arg Asn Ser Leu Leu Asn Met Ile Cys Gln 

                805                 810                 815     





Gln Val Glu Ala Ile Lys Lys Glu Met Gln Glu Leu Lys Leu Asn Ser 

            820                 825                 830         





Ser Lys Ser Ala Ser Arg His Arg Trp Pro Thr Glu Asn Tyr Gly Pro 

        835                 840                 845             





Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly Ala 

    850                 855                 860                 





Pro Leu Thr Glu Ala Ala His Arg His Phe Thr Ile Glu Lys His Gly 

865                 870                 875                 880 





Asp Ser Lys Trp Ile Ile Tyr Arg Phe Thr Lys Gln Leu Cys Gly Thr 

                885                 890                 895     





Glu Arg Ala Arg Ala Lys Ile Ser 

            900                 





<210>  274

<211>  10111

<212>  DNA

<213>  Homo sapiens



<400>  274

atggagactg aaagtgagag tagcacttta ggggatgaca gtgtcttctg gttggagtct       60



gaagttataa tccaggtgac tgactgtgaa gaggaagaaa gggaagagaa gttcaggaag      120



atgaagtcct cagtacattc tgaagaagat gattttgttc cagagctaca tagaaatgta      180



caccctcgag agcggcctga ttgggaagaa actcttagcg caatggcaag aggcgcagat      240



gttccagaga ttcctggaga tcttactctt aagacgtgtg gcagtacagc cagtatgaag      300



gttaagcatg tgaaaaagtt acccttcact aaaggtcact ttccgaagat ggctgaatgt      360



gcgcatttcc attatgagaa tgttgagttc ggcagcatac agctttcact ttcagaagaa      420



cagaatgaag taatgaaaaa tggctgtgaa tctaaagagc tggtctacct cgtgcagatt      480



gcttgtcagg gaaaaagttg gattgttaaa agaagttatg aagattttcg ggtacttgat      540



aaacatcttc atctgtgtat ttatgaccga agattttccc agctctcaga acttccccgt      600



tctgacaccc tgaaggacag tccagagtcg gtcactcaga tgcttatggc ttacctgtca      660



cgcctttcag ctatcgctgg caacaagatc aactgtgggc ccgcccttac ctggatggag      720



attgataata agggaaatca ccttttggtt catgaggagt catccatcaa cactcctgct      780



gtcggtgctg cccatgttat caagaggtac actgctcggg cccctgacga actgacctta      840



gaggtgggag acattgtttc tgttattgac atgcccccga aagtgttaag cacatggtgg      900



agaggcaagc acggattcca ggtgggactc ttccctggac actgtgttga gttaattaac      960



caaaaagttc cccagtcagt gaccaactca gtgccaaaac cagtgtctaa aaagcacggc     1020



aagctcatta cgttcttacg aacattcatg aagtctcgtc caacaaaaca gaagctgaag     1080



cagcggggaa tcttgaaaga gagggtgttt ggttgtgacc tgggggaaca ccttctaaat     1140



tctggttttg aagtgccgca ggttcttcaa agctgcacag cattcattga gagatatggc     1200



atcgtggatg gaatctatcg cctttctggt gttgcctcca atatccagag actacgccat     1260



gaatttgact ctgagcacgt ccccgacctg acgaaagaac cgtatgttca ggacatccat     1320



tctgtgggtt ccctatgtaa gctgtacttc cgggaactcc caaaccctct gcttacctac     1380



cagctgtatg agaaattttc tgatgcagtt tcagcagcaa cagatgaaga aaggctgata     1440



aaaatccacg atgtcatcca gcagctcccc ccaccacact acagaacact ggagttcctg     1500



atgagacact tgtctcttct agctgactat tgttccatca caaatatgca tgcaaaaaat     1560



ctagcaattg tttgggctcc aaacctgtta agatcaaaac agatagaatc tgcctgcttc     1620



agtggaacag cagctttcat ggaagtgagg attcagtctg tggttgttga gttcatcctg     1680



aatcacgttg atgtgctgtt cagcggcaga atcagcatgg ccatgcaaga gggggcagct     1740



tctctatcaa ggcccaagtc cctcctggta tcctctccat ccaccaaact gctgacattg     1800



gaagaggccc aggcacgaac acaagctcag gtcaattctc caattgtgac ggaaaataaa     1860



tatatcgaag taggagaagg acctgctgca cttcagggga aatttcatac cataattgag     1920



ttcccacttg aaagaaagag gcctcaaaat aagatgaaaa agtctcctgt gggtagctgg     1980



cgttcctttt tcaacttggg gaaatcatca tctgtttcta aacgaaagct gcagcggaat     2040



gagagtgagc cttcagagat gaaagccatg gctctgaaag gtggcagggc agaaggaacc     2100



ctccgttcag ctaaaagtga ggagtctctt acatctctcc atgcagttga tggtgattct     2160



aagctcttcc gacccagaag acccagatct tccagtgatg cactgtctgc ctcttttaat     2220



ggagaaatgc tggggaaccg ctgtaactcc tatgataatc tgcctcatga caatgagagt     2280



gaggaggaag gagggctgct tcatatccca gcccttatgt ctcctcattc agctgaggat     2340



gttgacttga gcccaccaga cattggagta gccagcctgg attttgatcc aatgtcattt     2400



caatgtagtc ctcctaaggc cgaatcagaa tgtctggaga gtggtgcttc ctttttagat     2460



tcaccaggat actccaagga taaaccaagt gccaataaaa aggatgcaga aacaggtagt     2520



agccaatgtc agactccagg aagcacagca agctctgaac ctgtctctcc tcttcaggag     2580



aaactgagtc cattctttac cctggacttg agcccaactg aagataaatc atctaagcca     2640



tcctccttta ctgaaaaggt cgtctatgct ttctctccga agataggacg gaaattaagc     2700



aaatcacctt ctatgagcat atctgagcca atttcagtga ccctaccacc acgggtgtca     2760



gaagtcattg gtacagtctc aaataccaca gctcagaatg catcatcttc aacctgggac     2820



aaatgcgttg aagaaaggga tgccacaaat agatccccca cccagatagt aaagatgaaa     2880



acaaatgaga cagttgccca agaagcatat gaatctgaag tccagcccct ggaccaggtg     2940



gctgctgaag aagtagaatt gccagggaaa gaggatcagt ctgtctcaag cagtcagagt     3000



aaggctgtag cttctggaca gactcagaca ggagcagtta cccatgaccc ccctcaggat     3060



tccgttcctg tcagttcagt ctctcttatc ccaccaccac cgcctccgaa aaatgttgcc     3120



cgaatgttgg cgctagcatt agctgagtcc gcacagcaag cctcaactca gtcattgaag     3180



agaccaggga cctctcaggc tgggtataca aattatggag acatagcggt ggctacaact     3240



gaagataatc tgtccagttc ttactctgca gttgctctag ataaggccta tttccaaacc     3300



gatcgaccag cagagcagtt ccacctccag aataatgcac caggaaactg tgaccatcct     3360



ctaccagaga caacagctac tggggatcct acccattcca acacaactga atctggggag     3420



caacatcacc aagtagactt aacagggaat cagccacatc aagcatattt atctggggac     3480



ccagaaaagg ccagaattac ttcagttccc ttagactcag agaagtctga tgatcatgta     3540



agtttccctg aagaccagtc tgggaagaac agtatgccaa ctgtctcctt cttggatcag     3600



gaccagtctc caccccgttt ctacagtgga gatcagcctc cttcttatct tggtgcaagt     3660



gtggataaac tccatcaccc tttagaattt gcagacaaat ctcccacacc tcctaattta     3720



cctagcgata aaatctaccc tccttctggg tcccccgaag agaataccag cacagccacc     3780



atgacttaca tgacaactac tccagcaaca gcccaaatga gcaccaagga agccagctgg     3840



gatgtggctg aacaacccac cactgctgat tttgctgctg ccacacttca gcgcacgcac     3900



agaactaatc gtccccttcc ccctccgcct tcccagagat ctgcagagca gccaccagtt     3960



gtggggcagg tacaagcagc aaccaatata ggattaaata attcccacaa ggttcaagga     4020



gtagttccag ttccagagag gccacctgaa cctcgagcca tggatgaccc tgcgtctgcc     4080



ttcatcagtg acagtggtgc tgctgctgct cagtgtccca tggctacagc tgtccagcca     4140



ggcctgcctg agaaagtgcg ggacggtgcc cgggtcccgc tgctgcacct gcgcgccgag     4200



tctgtccctg cgcatccctg tggctttcct gcaccactgc cccccaccag gatgatggag     4260



agtaagatga ttgctgccat acactccagc agtgcagatg ccaccagcag ttcaaattat     4320



cattcctttg tcactgcttc atccacctct gtggacgatg cattgccttt accacttcct     4380



gtcccacaac ctaagcatgc ttctcagaaa acagtttact cctcctttgc taggcccgat     4440



gtcaccactg aaccctttgg tccagataac tgtttgcatt tcaatatgac tccaaactgc     4500



cagtaccgtc cccagagtgt acctccccat cacaataaat tggagcagca ccaagtgtat     4560



ggtgccaggt cagagccacc agcctccatg ggtcttcgtt ataacacata tgtggcccca     4620



ggaagaaacg catctggaca ccactccaag ccatgcagcc gggtcgagta tgtgtcttct     4680



ttgagctcct ctgtcaggaa tacctgttac cccgaagaca ttccaccgta ccctaccatc     4740



cggagagtgc agtctctcca tgctccgccg tcttccatga ttcgctctgt tcccatttca     4800



cggacagaag ttcccccaga tgatgagcca gcctactgcc caagacctct gtaccaatat     4860



aagccatatc agtcctccca ggcccgctca gattatcatg tcactcagct tcagccttac     4920



tttgagaatg gccgggtcca ctacaggtat agcccatatt ccagttcttc tagttcctat     4980



tacagtccag atggggccct gtgtgatgtg gatgcctatg gcacagtcca gttgagaccc     5040



cttcaccgcc ttcccaatcg agactttgct ttctacaatc ctaggctgca aggaaagagc     5100



ttgtacagtt atgctggttt ggctccacgt ccccgggcca acgtgactgg ctatttctct     5160



cccaacgacc ataatgtagt cagcatgcct ccggctgctg atgtgaagca cacctacacc     5220



tcatgggatc ttgaggacat ggaaaaatac cgcatgcagt ccatccggag agagagccgt     5280



gctcggcaga aggtgaaagg gcctgtcatg tcccaatatg ataacatgac cccggcggtg     5340



caggacgact tgggtgggat ctatgtcatc catctgcgta gtaaatcaga tcctgggaaa     5400



actggacttc tctcagtggc agaaggaaag gagagccgcc atgcagccaa ggccatcagt     5460



cccgagggag aggaccgctt ctataggagg catcccgagg cagagatgga cagagcccac     5520



catcacggag gccatggtag cacgcagccg gagaagccat ccctgcctca gaagcagagc     5580



agcctgagga gcaggaagct tcctgacatg ggctgcagtc ttcctgagca cagggcacac     5640



caagaagcaa gccataggca gttctgtgag tcaaagaatg ggccccctta tccccaggga     5700



gctggccagt tagattatgg gtccaaaggg attccagaca cttctgagcc agtcagctac     5760



cacaactctg gagtaaaata tgctgcatcc gggcaagaat ctttaagact gaaccacaaa     5820



gaggtaaggc tctccaaaga gatggagcga ccctgggtta ggcagccttc tgccccagag     5880



aaacactcca gagactgcta caaggaggaa gaacacctca ctcagtcaat cgtcccaccc     5940



cctaaaccag agaggagtca tagcctcaaa ctccatcata cccagaacgt ggagagggac     6000



cccagtgtgc tgtaccagta ccaaccacac ggcaagcgcc agagcagtgt gactgttgtg     6060



tcccagtatg ataacctgga agattaccac tccctgcctc agcaccagcg aggagtcttt     6120



ggagggggcg gcatggggac gtatgtgccc cctggctttc cccatccaca gagcaggacc     6180



tatgctacag cgttgggtca aggggccttc ctgcccgcag agttgtcctt gcagcatcct     6240



gaaacacaga tccatgcaga atgagccctg cgagcaatag agttgaagca gcctctgctg     6300



gacagtggac tgttctattt ttttcaataa ccaaaaagat taaacaaaaa atactataaa     6360



acccctgacc acatttaaaa aatgataata aaagtaaaca aatcagcatc tttttcccct     6420



tccctgcttc attaccccct cttccatcta tagactttgt catttttgtc tttagaaaag     6480



atctgaagga tggtaaagcc ccgtgctgaa acccagtaga gaaacctgtc tcaggacaca     6540



cttgccatct agggctagct tgaaagagcc tgaggactgc ctttaactga atttgaattc     6600



agcattgtcc tttcttctta gtatttgctg cataattgag agcagttcac atcgatttcc     6660



tggtaggcgt ctgcattccc tgttgtgttc ctgcttctcc ttcagtagct gcacaacttg     6720



cgcagatcga cacactgttg tcacttcatt ctccccgtct gagaaggatc ttgtgttcag     6780



ttagagtcgt ggaaaaatcc ctgatccttc aaggtcagtc agacagttgg caacattata     6840



attaaaaata agaaattaag actttaaatt aaacatttgg tagagtcatc ataaaacacc     6900



agaccactta gactcaggct gaaccatact ctttctattc ttatttttca tccttgttcc     6960



tcacggttca gtgaacaggc tcatatcatg acagaatgga cttttaaaag ttagtactta     7020



aggaaacttc tttaggtgga agaaagtaaa gttcttattg tcagtgaact ttattagcac     7080



cagaaatctc tattgatgct tttaatgcat tgcctgcctt caggttttct tcttacccca     7140



cccctcaata agatttggtg aattgtaatt ctagtaaaac atgtcatacc attggttttc     7200



ctaaattatc aactttcttt cattaaaaaa aaaaaaaaaa aaaaaagccc agcatggttt     7260



gactggatag acacgcataa tttattatga atataaattt ccatgtttgt ttctgttcct     7320



aaaccagagt acgaggtccc tgggaattta agtagctacg cattatctat tattagactg     7380



caagttcctg caataactgc ttagttcaca gccccgtttc accagtggag ttctgggcag     7440



ttattgctgt cctaaggcat tactgtcgtt tgcttactct atacttgtgt ggtcacagtc     7500



ttcttgtaat taccatctac accagcattt caggtatagc tctttataac tctggagaca     7560



tgtaaaacat gtttaacacc cacgagtttt gaaagttgca ttccttatta gagtaggaac     7620



tctctagccc aactccattc tatgttctca gctccctcca ccccccaaaa tacatcagac     7680



tagcaaggca gtcctatgtt tacaaaacga gtttagattg tcatttcatt ccataactct     7740



taataatact caagttttat acattcacgt attttaaatg ctcggtctgt agaagacact     7800



aggagaattg cattccaatt actggatggt tgctgctctg gctttttaga acttgaaatt     7860



aatttttatt tagagcaaag gaggaaatct tttaagaggc taaaatcatg ctgctattat     7920



tgctgtgaaa ttgtataaag attaggattc atgccagttt ttattttaaa aaataatgtg     7980



cattttaagg gtttatattt agaaaaaaat aaaatgtttc aagaacaaca cattgatatg     8040



tggaaatatt ctataaggtt ttcttttgtt cccttagaat tcattggagg gatgcagtaa     8100



aaactgtagt agaaaccttg aaacacccat atgtgaaaag gtctgtggaa attgaggcct     8160



ctacattaaa agtgcagaac caactgtttt acagtcaaag tgctaggaaa cctgatagga     8220



tacttccctt tggcacaaaa acaccctggg tgctacatac aggagtatga cctttggtga     8280



atatgtggca ctaatttttt ttaccttaat catattcttg tcaagtaggc aacccattgc     8340



cccttggaga ccacaccagc cctgtaagtt ctcaccagca gcatggagat taggaagagg     8400



ggctgctgtg accaggagat acacacggct ttaagtaact gagagcctaa agaaagtaac     8460



ccagggagtc cggtccagtt ttaatatttg tggatttgtt gtcacacaca ttgtttagtc     8520



ctgaaactaa aacctatttt ataaatagta gggttaattc ctcgaaacaa tttctttatt     8580



aataaatgtc ctgtgggttt agaaatatca ggtaaatatt tgaatacaga atgatgattg     8640



caattactgt tacaagcgtg aaacacaaac ttcagatcaa atctagagtt gcttcattta     8700



atgcatgcta gcaacagcct taactttgga ttcagttatt tgaaacactt ttccggcatc     8760



tttccctttc taatgttgtg gggtggaaac cggatggcaa atcactgtga gccggatacc     8820



tcagcacagt ccaccttgtg tgtgacttca caaatggggg acttcacaaa tggggtaact     8880



gaatgttatt actttcaaat tttgacatgg agcattatga tcaaggaaat ggagctgcct     8940



tatacattaa acccgtgatt taatcctatt gacattttca tagccatgcc tccagatttt     9000



atctttttgg caaaattctg attccacagt ttggtctgat tgaaataaat attccctgga     9060



cgtctggcta aaaattttgc taacaatccc agaggtgcca ttttcttatt aataaatttc     9120



attggagcct tatttcttac tatattcaat ttcgtttcaa acctgcaagt ccctgggatg     9180



gtcccacgac tagggcctgc acatttctta caatggcaaa gcatttttta aaatttaggg     9240



tcaggttgaa aaattctagg actaattctg tagagaggag ggactgttaa ctaacgtgag     9300



tggggacgga ggagtaggtt accacatttg gagcagtaat agatgcaaac gatgtaaatt     9360



tgaaatttgc ccctttagtt aaagaaggag cctgcaaagt ccatttctct gttttcagcc     9420



ctgtcagtca cccatttagg atgttggcaa agtactgctt gagcagaatg tgtaagaaag     9480



taataatgaa agcaaaagta tgtcagacag ttacttcttc cacatggtta gaggcatgtg     9540



attttcagca ctgtgtgtta cagaaatgtc aggaatggtg tattataacg tgtgcaagat     9600



aatgtcagtg tgcacagagg gtcttttttc cttatctgat tagtactgtt aatgttcaaa     9660



gaataaaaat ggttttacag tttagattct gagatagcaa aacctgattt ttcaaccatg     9720



acctgcatga gagaagcatc ctaggaagtc ttagatcata cttttgagtt tttaatttta     9780



atttatatag tgttttttta tgtcttaata tttttgtgaa ctggtgtaaa ttgttaatgc     9840



atataagctt gtgtattttt gtaaatagtt ttgtgattta tttcttgccc catatgtaaa     9900



tatttagagt ctcatttctt gcaaacttat ttgaagctga gttgtgggtt tgggttttgt     9960



ttgtttcttt ggttgcaggg tggggtgggg ggtggcaggg gagggaggaa gggatttttg    10020



tacctggaga tggagatatc ttgtggttta aagcaaatgt cccactgaaa gtgattcaaa    10080



tatcaacaga attatttcag gttaaaacag a                                   10111





<210>  275

<211>  2087

<212>  PRT

<213>  Homo sapiens



<400>  275



Met Glu Thr Glu Ser Glu Ser Ser Thr Leu Gly Asp Asp Ser Val Phe 

1               5                   10                  15      





Trp Leu Glu Ser Glu Val Ile Ile Gln Val Thr Asp Cys Glu Glu Glu 

            20                  25                  30          





Glu Arg Glu Glu Lys Phe Arg Lys Met Lys Ser Ser Val His Ser Glu 

        35                  40                  45              





Glu Asp Asp Phe Val Pro Glu Leu His Arg Asn Val His Pro Arg Glu 

    50                  55                  60                  





Arg Pro Asp Trp Glu Glu Thr Leu Ser Ala Met Ala Arg Gly Ala Asp 

65                  70                  75                  80  





Val Pro Glu Ile Pro Gly Asp Leu Thr Leu Lys Thr Cys Gly Ser Thr 

                85                  90                  95      





Ala Ser Met Lys Val Lys His Val Lys Lys Leu Pro Phe Thr Lys Gly 

            100                 105                 110         





His Phe Pro Lys Met Ala Glu Cys Ala His Phe His Tyr Glu Asn Val 

        115                 120                 125             





Glu Phe Gly Ser Ile Gln Leu Ser Leu Ser Glu Glu Gln Asn Glu Val 

    130                 135                 140                 





Met Lys Asn Gly Cys Glu Ser Lys Glu Leu Val Tyr Leu Val Gln Ile 

145                 150                 155                 160 





Ala Cys Gln Gly Lys Ser Trp Ile Val Lys Arg Ser Tyr Glu Asp Phe 

                165                 170                 175     





Arg Val Leu Asp Lys His Leu His Leu Cys Ile Tyr Asp Arg Arg Phe 

            180                 185                 190         





Ser Gln Leu Ser Glu Leu Pro Arg Ser Asp Thr Leu Lys Asp Ser Pro 

        195                 200                 205             





Glu Ser Val Thr Gln Met Leu Met Ala Tyr Leu Ser Arg Leu Ser Ala 

    210                 215                 220                 





Ile Ala Gly Asn Lys Ile Asn Cys Gly Pro Ala Leu Thr Trp Met Glu 

225                 230                 235                 240 





Ile Asp Asn Lys Gly Asn His Leu Leu Val His Glu Glu Ser Ser Ile 

                245                 250                 255     





Asn Thr Pro Ala Val Gly Ala Ala His Val Ile Lys Arg Tyr Thr Ala 

            260                 265                 270         





Arg Ala Pro Asp Glu Leu Thr Leu Glu Val Gly Asp Ile Val Ser Val 

        275                 280                 285             





Ile Asp Met Pro Pro Lys Val Leu Ser Thr Trp Trp Arg Gly Lys His 

    290                 295                 300                 





Gly Phe Gln Val Gly Leu Phe Pro Gly His Cys Val Glu Leu Ile Asn 

305                 310                 315                 320 





Gln Lys Val Pro Gln Ser Val Thr Asn Ser Val Pro Lys Pro Val Ser 

                325                 330                 335     





Lys Lys His Gly Lys Leu Ile Thr Phe Leu Arg Thr Phe Met Lys Ser 

            340                 345                 350         





Arg Pro Thr Lys Gln Lys Leu Lys Gln Arg Gly Ile Leu Lys Glu Arg 

        355                 360                 365             





Val Phe Gly Cys Asp Leu Gly Glu His Leu Leu Asn Ser Gly Phe Glu 

    370                 375                 380                 





Val Pro Gln Val Leu Gln Ser Cys Thr Ala Phe Ile Glu Arg Tyr Gly 

385                 390                 395                 400 





Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ala Ser Asn Ile Gln 

                405                 410                 415     





Arg Leu Arg His Glu Phe Asp Ser Glu His Val Pro Asp Leu Thr Lys 

            420                 425                 430         





Glu Pro Tyr Val Gln Asp Ile His Ser Val Gly Ser Leu Cys Lys Leu 

        435                 440                 445             





Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Thr Tyr Gln Leu Tyr Glu 

    450                 455                 460                 





Lys Phe Ser Asp Ala Val Ser Ala Ala Thr Asp Glu Glu Arg Leu Ile 

465                 470                 475                 480 





Lys Ile His Asp Val Ile Gln Gln Leu Pro Pro Pro His Tyr Arg Thr 

                485                 490                 495     





Leu Glu Phe Leu Met Arg His Leu Ser Leu Leu Ala Asp Tyr Cys Ser 

            500                 505                 510         





Ile Thr Asn Met His Ala Lys Asn Leu Ala Ile Val Trp Ala Pro Asn 

        515                 520                 525             





Leu Leu Arg Ser Lys Gln Ile Glu Ser Ala Cys Phe Ser Gly Thr Ala 

    530                 535                 540                 





Ala Phe Met Glu Val Arg Ile Gln Ser Val Val Val Glu Phe Ile Leu 

545                 550                 555                 560 





Asn His Val Asp Val Leu Phe Ser Gly Arg Ile Ser Met Ala Met Gln 

                565                 570                 575     





Glu Gly Ala Ala Ser Leu Ser Arg Pro Lys Ser Leu Leu Val Ser Ser 

            580                 585                 590         





Pro Ser Thr Lys Leu Leu Thr Leu Glu Glu Ala Gln Ala Arg Thr Gln 

        595                 600                 605             





Ala Gln Val Asn Ser Pro Ile Val Thr Glu Asn Lys Tyr Ile Glu Val 

    610                 615                 620                 





Gly Glu Gly Pro Ala Ala Leu Gln Gly Lys Phe His Thr Ile Ile Glu 

625                 630                 635                 640 





Phe Pro Leu Glu Arg Lys Arg Pro Gln Asn Lys Met Lys Lys Ser Pro 

                645                 650                 655     





Val Gly Ser Trp Arg Ser Phe Phe Asn Leu Gly Lys Ser Ser Ser Val 

            660                 665                 670         





Ser Lys Arg Lys Leu Gln Arg Asn Glu Ser Glu Pro Ser Glu Met Lys 

        675                 680                 685             





Ala Met Ala Leu Lys Gly Gly Arg Ala Glu Gly Thr Leu Arg Ser Ala 

    690                 695                 700                 





Lys Ser Glu Glu Ser Leu Thr Ser Leu His Ala Val Asp Gly Asp Ser 

705                 710                 715                 720 





Lys Leu Phe Arg Pro Arg Arg Pro Arg Ser Ser Ser Asp Ala Leu Ser 

                725                 730                 735     





Ala Ser Phe Asn Gly Glu Met Leu Gly Asn Arg Cys Asn Ser Tyr Asp 

            740                 745                 750         





Asn Leu Pro His Asp Asn Glu Ser Glu Glu Glu Gly Gly Leu Leu His 

        755                 760                 765             





Ile Pro Ala Leu Met Ser Pro His Ser Ala Glu Asp Val Asp Leu Ser 

    770                 775                 780                 





Pro Pro Asp Ile Gly Val Ala Ser Leu Asp Phe Asp Pro Met Ser Phe 

785                 790                 795                 800 





Gln Cys Ser Pro Pro Lys Ala Glu Ser Glu Cys Leu Glu Ser Gly Ala 

                805                 810                 815     





Ser Phe Leu Asp Ser Pro Gly Tyr Ser Lys Asp Lys Pro Ser Ala Asn 

            820                 825                 830         





Lys Lys Asp Ala Glu Thr Gly Ser Ser Gln Cys Gln Thr Pro Gly Ser 

        835                 840                 845             





Thr Ala Ser Ser Glu Pro Val Ser Pro Leu Gln Glu Lys Leu Ser Pro 

    850                 855                 860                 





Phe Phe Thr Leu Asp Leu Ser Pro Thr Glu Asp Lys Ser Ser Lys Pro 

865                 870                 875                 880 





Ser Ser Phe Thr Glu Lys Val Val Tyr Ala Phe Ser Pro Lys Ile Gly 

                885                 890                 895     





Arg Lys Leu Ser Lys Ser Pro Ser Met Ser Ile Ser Glu Pro Ile Ser 

            900                 905                 910         





Val Thr Leu Pro Pro Arg Val Ser Glu Val Ile Gly Thr Val Ser Asn 

        915                 920                 925             





Thr Thr Ala Gln Asn Ala Ser Ser Ser Thr Trp Asp Lys Cys Val Glu 

    930                 935                 940                 





Glu Arg Asp Ala Thr Asn Arg Ser Pro Thr Gln Ile Val Lys Met Lys 

945                 950                 955                 960 





Thr Asn Glu Thr Val Ala Gln Glu Ala Tyr Glu Ser Glu Val Gln Pro 

                965                 970                 975     





Leu Asp Gln Val Ala Ala Glu Glu Val Glu Leu Pro Gly Lys Glu Asp 

            980                 985                 990         





Gln Ser Val Ser Ser Ser Gln Ser  Lys Ala Val Ala Ser  Gly Gln Thr 

        995                 1000                 1005             





Gln Thr  Gly Ala Val Thr His  Asp Pro Pro Gln Asp  Ser Val Pro 

    1010                 1015                 1020             





Val Ser  Ser Val Ser Leu Ile  Pro Pro Pro Pro Pro  Pro Lys Asn 

    1025                 1030                 1035             





Val Ala  Arg Met Leu Ala Leu  Ala Leu Ala Glu Ser  Ala Gln Gln 

    1040                 1045                 1050             





Ala Ser  Thr Gln Ser Leu Lys  Arg Pro Gly Thr Ser  Gln Ala Gly 

    1055                 1060                 1065             





Tyr Thr  Asn Tyr Gly Asp Ile  Ala Val Ala Thr Thr  Glu Asp Asn 

    1070                 1075                 1080             





Leu Ser  Ser Ser Tyr Ser Ala  Val Ala Leu Asp Lys  Ala Tyr Phe 

    1085                 1090                 1095             





Gln Thr  Asp Arg Pro Ala Glu  Gln Phe His Leu Gln  Asn Asn Ala 

    1100                 1105                 1110             





Pro Gly  Asn Cys Asp His Pro  Leu Pro Glu Thr Thr  Ala Thr Gly 

    1115                 1120                 1125             





Asp Pro  Thr His Ser Asn Thr  Thr Glu Ser Gly Glu  Gln His His 

    1130                 1135                 1140             





Gln Val  Asp Leu Thr Gly Asn  Gln Pro His Gln Ala  Tyr Leu Ser 

    1145                 1150                 1155             





Gly Asp  Pro Glu Lys Ala Arg  Ile Thr Ser Val Pro  Leu Asp Ser 

    1160                 1165                 1170             





Glu Lys  Ser Asp Asp His Val  Ser Phe Pro Glu Asp  Gln Ser Gly 

    1175                 1180                 1185             





Lys Asn  Ser Met Pro Thr Val  Ser Phe Leu Asp Gln  Asp Gln Ser 

    1190                 1195                 1200             





Pro Pro  Arg Phe Tyr Ser Gly  Asp Gln Pro Pro Ser  Tyr Leu Gly 

    1205                 1210                 1215             





Ala Ser  Val Asp Lys Leu His  His Pro Leu Glu Phe  Ala Asp Lys 

    1220                 1225                 1230             





Ser Pro  Thr Pro Pro Asn Leu  Pro Ser Asp Lys Ile  Tyr Pro Pro 

    1235                 1240                 1245             





Ser Gly  Ser Pro Glu Glu Asn  Thr Ser Thr Ala Thr  Met Thr Tyr 

    1250                 1255                 1260             





Met Thr  Thr Thr Pro Ala Thr  Ala Gln Met Ser Thr  Lys Glu Ala 

    1265                 1270                 1275             





Ser Trp  Asp Val Ala Glu Gln  Pro Thr Thr Ala Asp  Phe Ala Ala 

    1280                 1285                 1290             





Ala Thr  Leu Gln Arg Thr His  Arg Thr Asn Arg Pro  Leu Pro Pro 

    1295                 1300                 1305             





Pro Pro  Ser Gln Arg Ser Ala  Glu Gln Pro Pro Val  Val Gly Gln 

    1310                 1315                 1320             





Val Gln  Ala Ala Thr Asn Ile  Gly Leu Asn Asn Ser  His Lys Val 

    1325                 1330                 1335             





Gln Gly  Val Val Pro Val Pro  Glu Arg Pro Pro Glu  Pro Arg Ala 

    1340                 1345                 1350             





Met Asp  Asp Pro Ala Ser Ala  Phe Ile Ser Asp Ser  Gly Ala Ala 

    1355                 1360                 1365             





Ala Ala  Gln Cys Pro Met Ala  Thr Ala Val Gln Pro  Gly Leu Pro 

    1370                 1375                 1380             





Glu Lys  Val Arg Asp Gly Ala  Arg Val Pro Leu Leu  His Leu Arg 

    1385                 1390                 1395             





Ala Glu  Ser Val Pro Ala His  Pro Cys Gly Phe Pro  Ala Pro Leu 

    1400                 1405                 1410             





Pro Pro  Thr Arg Met Met Glu  Ser Lys Met Ile Ala  Ala Ile His 

    1415                 1420                 1425             





Ser Ser  Ser Ala Asp Ala Thr  Ser Ser Ser Asn Tyr  His Ser Phe 

    1430                 1435                 1440             





Val Thr  Ala Ser Ser Thr Ser  Val Asp Asp Ala Leu  Pro Leu Pro 

    1445                 1450                 1455             





Leu Pro  Val Pro Gln Pro Lys  His Ala Ser Gln Lys  Thr Val Tyr 

    1460                 1465                 1470             





Ser Ser  Phe Ala Arg Pro Asp  Val Thr Thr Glu Pro  Phe Gly Pro 

    1475                 1480                 1485             





Asp Asn  Cys Leu His Phe Asn  Met Thr Pro Asn Cys  Gln Tyr Arg 

    1490                 1495                 1500             





Pro Gln  Ser Val Pro Pro His  His Asn Lys Leu Glu  Gln His Gln 

    1505                 1510                 1515             





Val Tyr  Gly Ala Arg Ser Glu  Pro Pro Ala Ser Met  Gly Leu Arg 

    1520                 1525                 1530             





Tyr Asn  Thr Tyr Val Ala Pro  Gly Arg Asn Ala Ser  Gly His His 

    1535                 1540                 1545             





Ser Lys  Pro Cys Ser Arg Val  Glu Tyr Val Ser Ser  Leu Ser Ser 

    1550                 1555                 1560             





Ser Val  Arg Asn Thr Cys Tyr  Pro Glu Asp Ile Pro  Pro Tyr Pro 

    1565                 1570                 1575             





Thr Ile  Arg Arg Val Gln Ser  Leu His Ala Pro Pro  Ser Ser Met 

    1580                 1585                 1590             





Ile Arg  Ser Val Pro Ile Ser  Arg Thr Glu Val Pro  Pro Asp Asp 

    1595                 1600                 1605             





Glu Pro  Ala Tyr Cys Pro Arg  Pro Leu Tyr Gln Tyr  Lys Pro Tyr 

    1610                 1615                 1620             





Gln Ser  Ser Gln Ala Arg Ser  Asp Tyr His Val Thr  Gln Leu Gln 

    1625                 1630                 1635             





Pro Tyr  Phe Glu Asn Gly Arg  Val His Tyr Arg Tyr  Ser Pro Tyr 

    1640                 1645                 1650             





Ser Ser  Ser Ser Ser Ser Tyr  Tyr Ser Pro Asp Gly  Ala Leu Cys 

    1655                 1660                 1665             





Asp Val  Asp Ala Tyr Gly Thr  Val Gln Leu Arg Pro  Leu His Arg 

    1670                 1675                 1680             





Leu Pro  Asn Arg Asp Phe Ala  Phe Tyr Asn Pro Arg  Leu Gln Gly 

    1685                 1690                 1695             





Lys Ser  Leu Tyr Ser Tyr Ala  Gly Leu Ala Pro Arg  Pro Arg Ala 

    1700                 1705                 1710             





Asn Val  Thr Gly Tyr Phe Ser  Pro Asn Asp His Asn  Val Val Ser 

    1715                 1720                 1725             





Met Pro  Pro Ala Ala Asp Val  Lys His Thr Tyr Thr  Ser Trp Asp 

    1730                 1735                 1740             





Leu Glu  Asp Met Glu Lys Tyr  Arg Met Gln Ser Ile  Arg Arg Glu 

    1745                 1750                 1755             





Ser Arg  Ala Arg Gln Lys Val  Lys Gly Pro Val Met  Ser Gln Tyr 

    1760                 1765                 1770             





Asp Asn  Met Thr Pro Ala Val  Gln Asp Asp Leu Gly  Gly Ile Tyr 

    1775                 1780                 1785             





Val Ile  His Leu Arg Ser Lys  Ser Asp Pro Gly Lys  Thr Gly Leu 

    1790                 1795                 1800             





Leu Ser  Val Ala Glu Gly Lys  Glu Ser Arg His Ala  Ala Lys Ala 

    1805                 1810                 1815             





Ile Ser  Pro Glu Gly Glu Asp  Arg Phe Tyr Arg Arg  His Pro Glu 

    1820                 1825                 1830             





Ala Glu  Met Asp Arg Ala His  His His Gly Gly His  Gly Ser Thr 

    1835                 1840                 1845             





Gln Pro  Glu Lys Pro Ser Leu  Pro Gln Lys Gln Ser  Ser Leu Arg 

    1850                 1855                 1860             





Ser Arg  Lys Leu Pro Asp Met  Gly Cys Ser Leu Pro  Glu His Arg 

    1865                 1870                 1875             





Ala His  Gln Glu Ala Ser His  Arg Gln Phe Cys Glu  Ser Lys Asn 

    1880                 1885                 1890             





Gly Pro  Pro Tyr Pro Gln Gly  Ala Gly Gln Leu Asp  Tyr Gly Ser 

    1895                 1900                 1905             





Lys Gly  Ile Pro Asp Thr Ser  Glu Pro Val Ser Tyr  His Asn Ser 

    1910                 1915                 1920             





Gly Val  Lys Tyr Ala Ala Ser  Gly Gln Glu Ser Leu  Arg Leu Asn 

    1925                 1930                 1935             





His Lys  Glu Val Arg Leu Ser  Lys Glu Met Glu Arg  Pro Trp Val 

    1940                 1945                 1950             





Arg Gln  Pro Ser Ala Pro Glu  Lys His Ser Arg Asp  Cys Tyr Lys 

    1955                 1960                 1965             





Glu Glu  Glu His Leu Thr Gln  Ser Ile Val Pro Pro  Pro Lys Pro 

    1970                 1975                 1980             





Glu Arg  Ser His Ser Leu Lys  Leu His His Thr Gln  Asn Val Glu 

    1985                 1990                 1995             





Arg Asp  Pro Ser Val Leu Tyr  Gln Tyr Gln Pro His  Gly Lys Arg 

    2000                 2005                 2010             





Gln Ser  Ser Val Thr Val Val  Ser Gln Tyr Asp Asn  Leu Glu Asp 

    2015                 2020                 2025             





Tyr His  Ser Leu Pro Gln His  Gln Arg Gly Val Phe  Gly Gly Gly 

    2030                 2035                 2040             





Gly Met  Gly Thr Tyr Val Pro  Pro Gly Phe Pro His  Pro Gln Ser 

    2045                 2050                 2055             





Arg Thr  Tyr Ala Thr Ala Leu  Gly Gln Gly Ala Phe  Leu Pro Ala 

    2060                 2065                 2070             





Glu Leu  Ser Leu Gln His Pro  Glu Thr Gln Ile His  Ala Glu 

    2075                 2080                 2085         





<210>  276

<211>  9443

<212>  DNA

<213>  Homo sapiens



<400>  276

aaagcagtat gtgctgagag aggaggatta agctcctgga ggcagagctc tcccacacac       60



ttgctggctt gctgggctcc actgactgga ctgaaaacag ggccaagaaa actgctgctg      120



cagggggtcc tgaaaacagc tggaacccgg cagtgatgtg ggacctaact tgaagttaac      180



ctgtggtggt gaggttggaa ccagttggat tatgatttat tttctacact cttgtacgga      240



atgcagagct gttgtatcct gatgaatcta ctgctaaata tagtcatttg gaataatttt      300



aagtattgat cttaaaactt gtaccacaac aagagtgtct aaaaagcacg gcaagctcat      360



tacgttctta cgaacattca tgaagtctcg tccaacaaaa cagaagctga agcagcgggg      420



aatcttgaaa gagagggtgt ttggttgtga cctgggggaa caccttctaa attctggttt      480



tgaagtgccg caggttcttc aaagctgcac agcattcatt gagagatatg gcatcgtgga      540



tggaatctat cgcctttctg gtgttgcctc caatatccag agactacgcc atgaatttga      600



ctctgagcac gtccccgacc tgacgaaaga accgtatgtt caggacatcc attctgtggg      660



ttccctatgt aagctgtact tccgggaact cccaaaccct ctgcttacct accagctgta      720



tgagaaattt tctgatgcag tttcagcagc aacagatgaa gaaaggctga taaaaatcca      780



cgatgtcatc cagcagctcc ccccaccaca ctacagaaca ctggagttcc tgatgagaca      840



cttgtctctt ctagctgact attgttccat cacaaatatg catgcaaaaa atctagcaat      900



tgtttgggct ccaaacctgt taagatcaaa acagatagaa tctgcctgct tcagtggaac      960



agcagctttc atggaagtga ggattcagtc tgtggttgtt gagttcatcc tgaatcacgt     1020



tgatgtgctg ttcagcggca gaatcagcat ggccatgcaa gagggggcag cttctctatc     1080



aaggcccaag tccctcctgg tatcctctcc atccaccaaa ctgctgacat tggaagaggc     1140



ccaggcacga acacaagctc aggtcaattc tccaattgtg acggaaaata aatatatcga     1200



agtaggagaa ggacctgctg cacttcaggg gaaatttcat accataattg agttcccact     1260



tgaaagaaag aggcctcaaa ataagatgaa aaagtctcct gtgggtagct ggcgttcctt     1320



tttcaacttg gggaaatcat catctgtttc taaacgaaag ctgcagcgga atgagagtga     1380



gccttcagag atgaaagcca tggctctgaa aggtggcagg gcagaaggaa ccctccgttc     1440



agctaaaagt gaggagtctc ttacatctct ccatgcagtt gatggtgatt ctaagctctt     1500



ccgacccaga agacccagat cttccagtga tgcactgtct gcctctttta atggagaaat     1560



gctggggaac cgctgtaact cctatgataa tctgcctcat gacaatgaga gtgaggagga     1620



aggagggctg cttcatatcc cagcccttat gtctcctcat tcagctgagg atgttgactt     1680



gagcccacca gacattggag tagccagcct ggattttgat ccaatgtcat ttcaatgtag     1740



tcctcctaag gccgaatcag aatgtctgga gagtggtgct tcctttttag attcaccagg     1800



atactccaag gataaaccaa gtgccaataa aaaggatgca gaaacaggta gtagccaatg     1860



tcagactcca ggaagcacag caagctctga acctgtctct cctcttcagg agaaactgag     1920



tccattcttt accctggact tgagcccaac tgaagataaa tcatctaagc catcctcctt     1980



tactgaaaag gtcgtctatg ctttctctcc gaagatagga cggaaattaa gcaaatcacc     2040



ttctatgagc atatctgagc caatttcagt gaccctacca ccacgggtgt cagaagtcat     2100



tggtacagtc tcaaatacca cagctcagaa tgcatcatct tcaacctggg acaaatgcgt     2160



tgaagaaagg gatgccacaa atagatcccc cacccagata gtaaagatga aaacaaatga     2220



gacagttgcc caagaagcat atgaatctga agtccagccc ctggaccagg tggctgctga     2280



agaagtagaa ttgccaggga aagaggatca gtctgtctca agcagtcaga gtaaggctgt     2340



agcttctgga cagactcaga caggagcagt tacccatgac ccccctcagg attccgttcc     2400



tgtcagttca gtctctctta tcccaccacc accgcctccg aaaaatgttg cccgaatgtt     2460



ggcgctagca ttagctgagt ccgcacagca agcctcaact cagtcattga agagaccagg     2520



gacctctcag gctgggtata caaattatgg agacatagcg gtggctacaa ctgaagataa     2580



tctgtccagt tcttactctg cagttgctct agataaggcc tatttccaaa ccgatcgacc     2640



agcagagcag ttccacctcc agaataatgc accaggaaac tgtgaccatc ctctaccaga     2700



gacaacagct actggggatc ctacccattc caacacaact gaatctgggg agcaacatca     2760



ccaagtagac ttaacaggga atcagccaca tcaagcatat ttatctgggg acccagaaaa     2820



ggccagaatt acttcagttc ccttagactc agagaagtct gatgatcatg taagtttccc     2880



tgaagaccag tctgggaaga acagtatgcc aactgtctcc ttcttggatc aggaccagtc     2940



tccaccccgt ttctacagtg gagatcagcc tccttcttat cttggtgcaa gtgtggataa     3000



actccatcac cctttagaat ttgcagacaa atctcccaca cctcctaatt tacctagcga     3060



taaaatctac cctccttctg ggtcccccga agagaatacc agcacagcca ccatgactta     3120



catgacaact actccagcaa cagcccaaat gagcaccaag gaagccagct gggatgtggc     3180



tgaacaaccc accactgctg attttgctgc tgccacactt cagcgcacgc acagaactaa     3240



tcgtcccctt ccccctccgc cttcccagag atctgcagag cagccaccag ttgtggggca     3300



ggtacaagca gcaaccaata taggattaaa taattcccac aaggttcaag gagtagttcc     3360



agttccagag aggccacctg aacctcgagc catggatgac cctgcgtctg ccttcatcag     3420



tgacagtggt gctgctgctg ctcagtgtcc catggctaca gctgtccagc caggcctgcc     3480



tgagaaagtg cgggacggtg cccgggtccc gctgctgcac ctgcgcgccg agtctgtccc     3540



tgcgcatccc tgtggctttc ctgcaccact gccccccacc aggatgatgg agagtaagat     3600



gattgctgcc atacactcca gcagtgcaga tgccaccagc agttcaaatt atcattcctt     3660



tgtcactgct tcatccacct ctgtggacga tgcattgcct ttaccacttc ctgtcccaca     3720



acctaagcat gcttctcaga aaacagttta ctcctccttt gctaggcccg atgtcaccac     3780



tgaacccttt ggtccagata actgtttgca tttcaatatg actccaaact gccagtaccg     3840



tccccagagt gtacctcccc atcacaataa attggagcag caccaagtgt atggtgccag     3900



gtcagagcca ccagcctcca tgggtcttcg ttataacaca tatgtggccc caggaagaaa     3960



cgcatctgga caccactcca agccatgcag ccgggtcgag tatgtgtctt ctttgagctc     4020



ctctgtcagg aatacctgtt accccgaaga cattccaccg taccctacca tccggagagt     4080



gcagtctctc catgctccgc cgtcttccat gattcgctct gttcccattt cacggacaga     4140



agttccccca gatgatgagc cagcctactg cccaagacct ctgtaccaat ataagccata     4200



tcagtcctcc caggcccgct cagattatca tgtcactcag cttcagcctt actttgagaa     4260



tggccgggtc cactacaggt atagcccata ttccagttct tctagttcct attacagtcc     4320



agatggggcc ctgtgtgatg tggatgccta tggcacagtc cagttgagac cccttcaccg     4380



ccttcccaat cgagactttg ctttctacaa tcctaggctg caaggaaaga gcttgtacag     4440



ttatgctggt ttggctccac gtccccgggc caacgtgact ggctatttct ctcccaacga     4500



ccataatgta gtcagcatgc ctccggctgc tgatgtgaag cacacctaca cctcatggga     4560



tcttgaggac atggaaaaat accgcatgca gtccatccgg agagagagcc gtgctcggca     4620



gaaggtgaaa gggcctgtca tgtcccaata tgataacatg accccggcgg tgcaggacga     4680



cttgggtggg atctatgtca tccatctgcg tagtaaatca gatcctggga aaactggact     4740



tctctcagtg gcagaaggaa aggagagccg ccatgcagcc aaggccatca gtcccgaggg     4800



agaggaccgc ttctatagga ggcatcccga ggcagagatg gacagagccc accatcacgg     4860



aggccatggt agcacgcagc cggagaagcc atccctgcct cagaagcaga gcagcctgag     4920



gagcaggaag cttcctgaca tgggctgcag tcttcctgag cacagggcac accaagaagc     4980



aagccatagg cagttctgtg agtcaaagaa tgggccccct tatccccagg gagctggcca     5040



gttagattat gggtccaaag ggattccaga cacttctgag ccagtcagct accacaactc     5100



tggagtaaaa tatgctgcat ccgggcaaga atctttaaga ctgaaccaca aagaggtaag     5160



gctctccaaa gagatggagc gaccctgggt taggcagcct tctgccccag agaaacactc     5220



cagagactgc tacaaggagg aagaacacct cactcagtca atcgtcccac cccctaaacc     5280



agagaggagt catagcctca aactccatca tacccagaac gtggagaggg accccagtgt     5340



gctgtaccag taccaaccac acggcaagcg ccagagcagt gtgactgttg tgtcccagta     5400



tgataacctg gaagattacc actccctgcc tcagcaccag cgaggagtct ttggaggggg     5460



cggcatgggg acgtatgtgc cccctggctt tccccatcca cagagcagga cctatgctac     5520



agcgttgggt caaggggcct tcctgcccgc agagttgtcc ttgcagcatc ctgaaacaca     5580



gatccatgca gaatgagccc tgcgagcaat agagttgaag cagcctctgc tggacagtgg     5640



actgttctat ttttttcaat aaccaaaaag attaaacaaa aaatactata aaacccctga     5700



ccacatttaa aaaatgataa taaaagtaaa caaatcagca tctttttccc cttccctgct     5760



tcattacccc ctcttccatc tatagacttt gtcatttttg tctttagaaa agatctgaag     5820



gatggtaaag ccccgtgctg aaacccagta gagaaacctg tctcaggaca cacttgccat     5880



ctagggctag cttgaaagag cctgaggact gcctttaact gaatttgaat tcagcattgt     5940



cctttcttct tagtatttgc tgcataattg agagcagttc acatcgattt cctggtaggc     6000



gtctgcattc cctgttgtgt tcctgcttct ccttcagtag ctgcacaact tgcgcagatc     6060



gacacactgt tgtcacttca ttctccccgt ctgagaagga tcttgtgttc agttagagtc     6120



gtggaaaaat ccctgatcct tcaaggtcag tcagacagtt ggcaacatta taattaaaaa     6180



taagaaatta agactttaaa ttaaacattt ggtagagtca tcataaaaca ccagaccact     6240



tagactcagg ctgaaccata ctctttctat tcttattttt catccttgtt cctcacggtt     6300



cagtgaacag gctcatatca tgacagaatg gacttttaaa agttagtact taaggaaact     6360



tctttaggtg gaagaaagta aagttcttat tgtcagtgaa ctttattagc accagaaatc     6420



tctattgatg cttttaatgc attgcctgcc ttcaggtttt cttcttaccc cacccctcaa     6480



taagatttgg tgaattgtaa ttctagtaaa acatgtcata ccattggttt tcctaaatta     6540



tcaactttct ttcattaaaa aaaaaaaaaa aaaaaaaagc ccagcatggt ttgactggat     6600



agacacgcat aatttattat gaatataaat ttccatgttt gtttctgttc ctaaaccaga     6660



gtacgaggtc cctgggaatt taagtagcta cgcattatct attattagac tgcaagttcc     6720



tgcaataact gcttagttca cagccccgtt tcaccagtgg agttctgggc agttattgct     6780



gtcctaaggc attactgtcg tttgcttact ctatacttgt gtggtcacag tcttcttgta     6840



attaccatct acaccagcat ttcaggtata gctctttata actctggaga catgtaaaac     6900



atgtttaaca cccacgagtt ttgaaagttg cattccttat tagagtagga actctctagc     6960



ccaactccat tctatgttct cagctccctc caccccccaa aatacatcag actagcaagg     7020



cagtcctatg tttacaaaac gagtttagat tgtcatttca ttccataact cttaataata     7080



ctcaagtttt atacattcac gtattttaaa tgctcggtct gtagaagaca ctaggagaat     7140



tgcattccaa ttactggatg gttgctgctc tggcttttta gaacttgaaa ttaattttta     7200



tttagagcaa aggaggaaat cttttaagag gctaaaatca tgctgctatt attgctgtga     7260



aattgtataa agattaggat tcatgccagt ttttatttta aaaaataatg tgcattttaa     7320



gggtttatat ttagaaaaaa ataaaatgtt tcaagaacaa cacattgata tgtggaaata     7380



ttctataagg ttttcttttg ttcccttaga attcattgga gggatgcagt aaaaactgta     7440



gtagaaacct tgaaacaccc atatgtgaaa aggtctgtgg aaattgaggc ctctacatta     7500



aaagtgcaga accaactgtt ttacagtcaa agtgctagga aacctgatag gatacttccc     7560



tttggcacaa aaacaccctg ggtgctacat acaggagtat gacctttggt gaatatgtgg     7620



cactaatttt ttttacctta atcatattct tgtcaagtag gcaacccatt gccccttgga     7680



gaccacacca gccctgtaag ttctcaccag cagcatggag attaggaaga ggggctgctg     7740



tgaccaggag atacacacgg ctttaagtaa ctgagagcct aaagaaagta acccagggag     7800



tccggtccag ttttaatatt tgtggatttg ttgtcacaca cattgtttag tcctgaaact     7860



aaaacctatt ttataaatag tagggttaat tcctcgaaac aatttcttta ttaataaatg     7920



tcctgtgggt ttagaaatat caggtaaata tttgaataca gaatgatgat tgcaattact     7980



gttacaagcg tgaaacacaa acttcagatc aaatctagag ttgcttcatt taatgcatgc     8040



tagcaacagc cttaactttg gattcagtta tttgaaacac ttttccggca tctttccctt     8100



tctaatgttg tggggtggaa accggatggc aaatcactgt gagccggata cctcagcaca     8160



gtccaccttg tgtgtgactt cacaaatggg ggacttcaca aatggggtaa ctgaatgtta     8220



ttactttcaa attttgacat ggagcattat gatcaaggaa atggagctgc cttatacatt     8280



aaacccgtga tttaatccta ttgacatttt catagccatg cctccagatt ttatcttttt     8340



ggcaaaattc tgattccaca gtttggtctg attgaaataa atattccctg gacgtctggc     8400



taaaaatttt gctaacaatc ccagaggtgc cattttctta ttaataaatt tcattggagc     8460



cttatttctt actatattca atttcgtttc aaacctgcaa gtccctggga tggtcccacg     8520



actagggcct gcacatttct tacaatggca aagcattttt taaaatttag ggtcaggttg     8580



aaaaattcta ggactaattc tgtagagagg agggactgtt aactaacgtg agtggggacg     8640



gaggagtagg ttaccacatt tggagcagta atagatgcaa acgatgtaaa tttgaaattt     8700



gcccctttag ttaaagaagg agcctgcaaa gtccatttct ctgttttcag ccctgtcagt     8760



cacccattta ggatgttggc aaagtactgc ttgagcagaa tgtgtaagaa agtaataatg     8820



aaagcaaaag tatgtcagac agttacttct tccacatggt tagaggcatg tgattttcag     8880



cactgtgtgt tacagaaatg tcaggaatgg tgtattataa cgtgtgcaag ataatgtcag     8940



tgtgcacaga gggtcttttt tccttatctg attagtactg ttaatgttca aagaataaaa     9000



atggttttac agtttagatt ctgagatagc aaaacctgat ttttcaacca tgacctgcat     9060



gagagaagca tcctaggaag tcttagatca tacttttgag tttttaattt taatttatat     9120



agtgtttttt tatgtcttaa tatttttgtg aactggtgta aattgttaat gcatataagc     9180



ttgtgtattt ttgtaaatag ttttgtgatt tatttcttgc cccatatgta aatatttaga     9240



gtctcatttc ttgcaaactt atttgaagct gagttgtggg tttgggtttt gtttgtttct     9300



ttggttgcag ggtggggtgg ggggtggcag gggagggagg aagggatttt tgtacctgga     9360



gatggagata tcttgtggtt taaagcaaat gtcccactga aagtgattca aatatcaaca     9420



gaattatttc aggttaaaac aga                                             9443





<210>  277

<211>  1738

<212>  PRT

<213>  Homo sapiens



<400>  277



Met Lys Ser Arg Pro Thr Lys Gln Lys Leu Lys Gln Arg Gly Ile Leu 

1               5                   10                  15      





Lys Glu Arg Val Phe Gly Cys Asp Leu Gly Glu His Leu Leu Asn Ser 

            20                  25                  30          





Gly Phe Glu Val Pro Gln Val Leu Gln Ser Cys Thr Ala Phe Ile Glu 

        35                  40                  45              





Arg Tyr Gly Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ala Ser 

    50                  55                  60                  





Asn Ile Gln Arg Leu Arg His Glu Phe Asp Ser Glu His Val Pro Asp 

65                  70                  75                  80  





Leu Thr Lys Glu Pro Tyr Val Gln Asp Ile His Ser Val Gly Ser Leu 

                85                  90                  95      





Cys Lys Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Thr Tyr Gln 

            100                 105                 110         





Leu Tyr Glu Lys Phe Ser Asp Ala Val Ser Ala Ala Thr Asp Glu Glu 

        115                 120                 125             





Arg Leu Ile Lys Ile His Asp Val Ile Gln Gln Leu Pro Pro Pro His 

    130                 135                 140                 





Tyr Arg Thr Leu Glu Phe Leu Met Arg His Leu Ser Leu Leu Ala Asp 

145                 150                 155                 160 





Tyr Cys Ser Ile Thr Asn Met His Ala Lys Asn Leu Ala Ile Val Trp 

                165                 170                 175     





Ala Pro Asn Leu Leu Arg Ser Lys Gln Ile Glu Ser Ala Cys Phe Ser 

            180                 185                 190         





Gly Thr Ala Ala Phe Met Glu Val Arg Ile Gln Ser Val Val Val Glu 

        195                 200                 205             





Phe Ile Leu Asn His Val Asp Val Leu Phe Ser Gly Arg Ile Ser Met 

    210                 215                 220                 





Ala Met Gln Glu Gly Ala Ala Ser Leu Ser Arg Pro Lys Ser Leu Leu 

225                 230                 235                 240 





Val Ser Ser Pro Ser Thr Lys Leu Leu Thr Leu Glu Glu Ala Gln Ala 

                245                 250                 255     





Arg Thr Gln Ala Gln Val Asn Ser Pro Ile Val Thr Glu Asn Lys Tyr 

            260                 265                 270         





Ile Glu Val Gly Glu Gly Pro Ala Ala Leu Gln Gly Lys Phe His Thr 

        275                 280                 285             





Ile Ile Glu Phe Pro Leu Glu Arg Lys Arg Pro Gln Asn Lys Met Lys 

    290                 295                 300                 





Lys Ser Pro Val Gly Ser Trp Arg Ser Phe Phe Asn Leu Gly Lys Ser 

305                 310                 315                 320 





Ser Ser Val Ser Lys Arg Lys Leu Gln Arg Asn Glu Ser Glu Pro Ser 

                325                 330                 335     





Glu Met Lys Ala Met Ala Leu Lys Gly Gly Arg Ala Glu Gly Thr Leu 

            340                 345                 350         





Arg Ser Ala Lys Ser Glu Glu Ser Leu Thr Ser Leu His Ala Val Asp 

        355                 360                 365             





Gly Asp Ser Lys Leu Phe Arg Pro Arg Arg Pro Arg Ser Ser Ser Asp 

    370                 375                 380                 





Ala Leu Ser Ala Ser Phe Asn Gly Glu Met Leu Gly Asn Arg Cys Asn 

385                 390                 395                 400 





Ser Tyr Asp Asn Leu Pro His Asp Asn Glu Ser Glu Glu Glu Gly Gly 

                405                 410                 415     





Leu Leu His Ile Pro Ala Leu Met Ser Pro His Ser Ala Glu Asp Val 

            420                 425                 430         





Asp Leu Ser Pro Pro Asp Ile Gly Val Ala Ser Leu Asp Phe Asp Pro 

        435                 440                 445             





Met Ser Phe Gln Cys Ser Pro Pro Lys Ala Glu Ser Glu Cys Leu Glu 

    450                 455                 460                 





Ser Gly Ala Ser Phe Leu Asp Ser Pro Gly Tyr Ser Lys Asp Lys Pro 

465                 470                 475                 480 





Ser Ala Asn Lys Lys Asp Ala Glu Thr Gly Ser Ser Gln Cys Gln Thr 

                485                 490                 495     





Pro Gly Ser Thr Ala Ser Ser Glu Pro Val Ser Pro Leu Gln Glu Lys 

            500                 505                 510         





Leu Ser Pro Phe Phe Thr Leu Asp Leu Ser Pro Thr Glu Asp Lys Ser 

        515                 520                 525             





Ser Lys Pro Ser Ser Phe Thr Glu Lys Val Val Tyr Ala Phe Ser Pro 

    530                 535                 540                 





Lys Ile Gly Arg Lys Leu Ser Lys Ser Pro Ser Met Ser Ile Ser Glu 

545                 550                 555                 560 





Pro Ile Ser Val Thr Leu Pro Pro Arg Val Ser Glu Val Ile Gly Thr 

                565                 570                 575     





Val Ser Asn Thr Thr Ala Gln Asn Ala Ser Ser Ser Thr Trp Asp Lys 

            580                 585                 590         





Cys Val Glu Glu Arg Asp Ala Thr Asn Arg Ser Pro Thr Gln Ile Val 

        595                 600                 605             





Lys Met Lys Thr Asn Glu Thr Val Ala Gln Glu Ala Tyr Glu Ser Glu 

    610                 615                 620                 





Val Gln Pro Leu Asp Gln Val Ala Ala Glu Glu Val Glu Leu Pro Gly 

625                 630                 635                 640 





Lys Glu Asp Gln Ser Val Ser Ser Ser Gln Ser Lys Ala Val Ala Ser 

                645                 650                 655     





Gly Gln Thr Gln Thr Gly Ala Val Thr His Asp Pro Pro Gln Asp Ser 

            660                 665                 670         





Val Pro Val Ser Ser Val Ser Leu Ile Pro Pro Pro Pro Pro Pro Lys 

        675                 680                 685             





Asn Val Ala Arg Met Leu Ala Leu Ala Leu Ala Glu Ser Ala Gln Gln 

    690                 695                 700                 





Ala Ser Thr Gln Ser Leu Lys Arg Pro Gly Thr Ser Gln Ala Gly Tyr 

705                 710                 715                 720 





Thr Asn Tyr Gly Asp Ile Ala Val Ala Thr Thr Glu Asp Asn Leu Ser 

                725                 730                 735     





Ser Ser Tyr Ser Ala Val Ala Leu Asp Lys Ala Tyr Phe Gln Thr Asp 

            740                 745                 750         





Arg Pro Ala Glu Gln Phe His Leu Gln Asn Asn Ala Pro Gly Asn Cys 

        755                 760                 765             





Asp His Pro Leu Pro Glu Thr Thr Ala Thr Gly Asp Pro Thr His Ser 

    770                 775                 780                 





Asn Thr Thr Glu Ser Gly Glu Gln His His Gln Val Asp Leu Thr Gly 

785                 790                 795                 800 





Asn Gln Pro His Gln Ala Tyr Leu Ser Gly Asp Pro Glu Lys Ala Arg 

                805                 810                 815     





Ile Thr Ser Val Pro Leu Asp Ser Glu Lys Ser Asp Asp His Val Ser 

            820                 825                 830         





Phe Pro Glu Asp Gln Ser Gly Lys Asn Ser Met Pro Thr Val Ser Phe 

        835                 840                 845             





Leu Asp Gln Asp Gln Ser Pro Pro Arg Phe Tyr Ser Gly Asp Gln Pro 

    850                 855                 860                 





Pro Ser Tyr Leu Gly Ala Ser Val Asp Lys Leu His His Pro Leu Glu 

865                 870                 875                 880 





Phe Ala Asp Lys Ser Pro Thr Pro Pro Asn Leu Pro Ser Asp Lys Ile 

                885                 890                 895     





Tyr Pro Pro Ser Gly Ser Pro Glu Glu Asn Thr Ser Thr Ala Thr Met 

            900                 905                 910         





Thr Tyr Met Thr Thr Thr Pro Ala Thr Ala Gln Met Ser Thr Lys Glu 

        915                 920                 925             





Ala Ser Trp Asp Val Ala Glu Gln Pro Thr Thr Ala Asp Phe Ala Ala 

    930                 935                 940                 





Ala Thr Leu Gln Arg Thr His Arg Thr Asn Arg Pro Leu Pro Pro Pro 

945                 950                 955                 960 





Pro Ser Gln Arg Ser Ala Glu Gln Pro Pro Val Val Gly Gln Val Gln 

                965                 970                 975     





Ala Ala Thr Asn Ile Gly Leu Asn Asn Ser His Lys Val Gln Gly Val 

            980                 985                 990         





Val Pro Val Pro Glu Arg Pro Pro  Glu Pro Arg Ala Met  Asp Asp Pro 

        995                 1000                 1005             





Ala Ser  Ala Phe Ile Ser Asp  Ser Gly Ala Ala Ala  Ala Gln Cys 

    1010                 1015                 1020             





Pro Met  Ala Thr Ala Val Gln  Pro Gly Leu Pro Glu  Lys Val Arg 

    1025                 1030                 1035             





Asp Gly  Ala Arg Val Pro Leu  Leu His Leu Arg Ala  Glu Ser Val 

    1040                 1045                 1050             





Pro Ala  His Pro Cys Gly Phe  Pro Ala Pro Leu Pro  Pro Thr Arg 

    1055                 1060                 1065             





Met Met  Glu Ser Lys Met Ile  Ala Ala Ile His Ser  Ser Ser Ala 

    1070                 1075                 1080             





Asp Ala  Thr Ser Ser Ser Asn  Tyr His Ser Phe Val  Thr Ala Ser 

    1085                 1090                 1095             





Ser Thr  Ser Val Asp Asp Ala  Leu Pro Leu Pro Leu  Pro Val Pro 

    1100                 1105                 1110             





Gln Pro  Lys His Ala Ser Gln  Lys Thr Val Tyr Ser  Ser Phe Ala 

    1115                 1120                 1125             





Arg Pro  Asp Val Thr Thr Glu  Pro Phe Gly Pro Asp  Asn Cys Leu 

    1130                 1135                 1140             





His Phe  Asn Met Thr Pro Asn  Cys Gln Tyr Arg Pro  Gln Ser Val 

    1145                 1150                 1155             





Pro Pro  His His Asn Lys Leu  Glu Gln His Gln Val  Tyr Gly Ala 

    1160                 1165                 1170             





Arg Ser  Glu Pro Pro Ala Ser  Met Gly Leu Arg Tyr  Asn Thr Tyr 

    1175                 1180                 1185             





Val Ala  Pro Gly Arg Asn Ala  Ser Gly His His Ser  Lys Pro Cys 

    1190                 1195                 1200             





Ser Arg  Val Glu Tyr Val Ser  Ser Leu Ser Ser Ser  Val Arg Asn 

    1205                 1210                 1215             





Thr Cys  Tyr Pro Glu Asp Ile  Pro Pro Tyr Pro Thr  Ile Arg Arg 

    1220                 1225                 1230             





Val Gln  Ser Leu His Ala Pro  Pro Ser Ser Met Ile  Arg Ser Val 

    1235                 1240                 1245             





Pro Ile  Ser Arg Thr Glu Val  Pro Pro Asp Asp Glu  Pro Ala Tyr 

    1250                 1255                 1260             





Cys Pro  Arg Pro Leu Tyr Gln  Tyr Lys Pro Tyr Gln  Ser Ser Gln 

    1265                 1270                 1275             





Ala Arg  Ser Asp Tyr His Val  Thr Gln Leu Gln Pro  Tyr Phe Glu 

    1280                 1285                 1290             





Asn Gly  Arg Val His Tyr Arg  Tyr Ser Pro Tyr Ser  Ser Ser Ser 

    1295                 1300                 1305             





Ser Ser  Tyr Tyr Ser Pro Asp  Gly Ala Leu Cys Asp  Val Asp Ala 

    1310                 1315                 1320             





Tyr Gly  Thr Val Gln Leu Arg  Pro Leu His Arg Leu  Pro Asn Arg 

    1325                 1330                 1335             





Asp Phe  Ala Phe Tyr Asn Pro  Arg Leu Gln Gly Lys  Ser Leu Tyr 

    1340                 1345                 1350             





Ser Tyr  Ala Gly Leu Ala Pro  Arg Pro Arg Ala Asn  Val Thr Gly 

    1355                 1360                 1365             





Tyr Phe  Ser Pro Asn Asp His  Asn Val Val Ser Met  Pro Pro Ala 

    1370                 1375                 1380             





Ala Asp  Val Lys His Thr Tyr  Thr Ser Trp Asp Leu  Glu Asp Met 

    1385                 1390                 1395             





Glu Lys  Tyr Arg Met Gln Ser  Ile Arg Arg Glu Ser  Arg Ala Arg 

    1400                 1405                 1410             





Gln Lys  Val Lys Gly Pro Val  Met Ser Gln Tyr Asp  Asn Met Thr 

    1415                 1420                 1425             





Pro Ala  Val Gln Asp Asp Leu  Gly Gly Ile Tyr Val  Ile His Leu 

    1430                 1435                 1440             





Arg Ser  Lys Ser Asp Pro Gly  Lys Thr Gly Leu Leu  Ser Val Ala 

    1445                 1450                 1455             





Glu Gly  Lys Glu Ser Arg His  Ala Ala Lys Ala Ile  Ser Pro Glu 

    1460                 1465                 1470             





Gly Glu  Asp Arg Phe Tyr Arg  Arg His Pro Glu Ala  Glu Met Asp 

    1475                 1480                 1485             





Arg Ala  His His His Gly Gly  His Gly Ser Thr Gln  Pro Glu Lys 

    1490                 1495                 1500             





Pro Ser  Leu Pro Gln Lys Gln  Ser Ser Leu Arg Ser  Arg Lys Leu 

    1505                 1510                 1515             





Pro Asp  Met Gly Cys Ser Leu  Pro Glu His Arg Ala  His Gln Glu 

    1520                 1525                 1530             





Ala Ser  His Arg Gln Phe Cys  Glu Ser Lys Asn Gly  Pro Pro Tyr 

    1535                 1540                 1545             





Pro Gln  Gly Ala Gly Gln Leu  Asp Tyr Gly Ser Lys  Gly Ile Pro 

    1550                 1555                 1560             





Asp Thr  Ser Glu Pro Val Ser  Tyr His Asn Ser Gly  Val Lys Tyr 

    1565                 1570                 1575             





Ala Ala  Ser Gly Gln Glu Ser  Leu Arg Leu Asn His  Lys Glu Val 

    1580                 1585                 1590             





Arg Leu  Ser Lys Glu Met Glu  Arg Pro Trp Val Arg  Gln Pro Ser 

    1595                 1600                 1605             





Ala Pro  Glu Lys His Ser Arg  Asp Cys Tyr Lys Glu  Glu Glu His 

    1610                 1615                 1620             





Leu Thr  Gln Ser Ile Val Pro  Pro Pro Lys Pro Glu  Arg Ser His 

    1625                 1630                 1635             





Ser Leu  Lys Leu His His Thr  Gln Asn Val Glu Arg  Asp Pro Ser 

    1640                 1645                 1650             





Val Leu  Tyr Gln Tyr Gln Pro  His Gly Lys Arg Gln  Ser Ser Val 

    1655                 1660                 1665             





Thr Val  Val Ser Gln Tyr Asp  Asn Leu Glu Asp Tyr  His Ser Leu 

    1670                 1675                 1680             





Pro Gln  His Gln Arg Gly Val  Phe Gly Gly Gly Gly  Met Gly Thr 

    1685                 1690                 1695             





Tyr Val  Pro Pro Gly Phe Pro  His Pro Gln Ser Arg  Thr Tyr Ala 

    1700                 1705                 1710             





Thr Ala  Leu Gly Gln Gly Ala  Phe Leu Pro Ala Glu  Leu Ser Leu 

    1715                 1720                 1725             





Gln His  Pro Glu Thr Gln Ile  His Ala Glu 

    1730                 1735             





<210>  278

<211>  5136

<212>  DNA

<213>  Homo sapiens



<400>  278

atggagcgct cgcagagccg cctcagtctg tccgcctcct tcgaggcgct cgccatctac       60



ttcccgtgca tgaactcctt cgacgacgag gacgcagggg acagccggag gctgaagggg      120



gccatccaga ggagcacgga gacgggcctg gcagtggaga tgcccagccg gacactgcgc      180



caggccagcc acgagtccat tgaggacagc atgaacagct atggctcaga gggcaacctt      240



aactatggag gagtttgcct ggcgtcggac gcccagttca gtgacttcct gggaagcatg      300



gggccggcac agtttgtggg ccgccagacc ctggccacca cacccatggg ggatgtggag      360



atcggtctgc aggagcggaa cggtcagttg gaggtggaca ttatccaggc tcggggactg      420



acagccaagc caggctccaa gacactgcca gcggcctaca tcaaggccta cctgctagag      480



aatggcatct gcattgccaa gaagaagacc aaagtcgctc gcaagtcgct ggacccactg      540



tataaccagg tgctgctgtt tcctgagagt ccccagggca aagtcctcca ggtgatcgtg      600



tgggggaact acgggcggat ggagcggaag cagttcatgg gtgtggctcg cgtgctgctg      660



gaggagctgg acttgaccac cctggccgtg ggctggtaca agctcttccc cacctcctcc      720



atggtggacc cagccacagg ccccctgctc cggcaggcat cccagttgtc cctcgagagc      780



accgtggggc cctgcggaga acgatcttag tgctggaatg gggaggggct ccccaagatg      840



gcctggagac cacccagccc tgacctggga ccccaggccc aggggcacat tgaacaggag      900



gacggggctc tcccccacag tggggaagca gaacggggag acctgccccc ccttgggccc      960



ctcctcaccc cttctttgcc tcctaccccc gagacctccc ctctcccaac gggattggct     1020



acacttttga cttggccggt tcttgacctg gtggatgtgg ctgcagtcca gagaaaggaa     1080



agattgaggt ggcagagcag accactctcc cttcccaaac tgtccaactt ctcccccttt     1140



ttgcctcctc ggaagctcgc tgcccagagc catgtccaga acccagccgg ccatctccat     1200



ggtgccaatt accagcaagt gtctttcctg cggcaccggg ttcaggcagc tactcctgcc     1260



ccagagatga aggggcagct ttgcaaggat ccggagccag ctcccagggg cccagagccc     1320



cccacttgaa gaggagcttg agcttccctc tgcctgcccg tggaaggagc tttgccgcag     1380



cctgtccgag tccatccgtc cgtcccctcc tgcctgcccc tcttctggtg gctctaggaa     1440



ttggggttca gcagggacca aaggaaagga ggaggtgccg ggggcctggc acagacccct     1500



aggtgcctcg ctccatggga ttgcaacaag ctagtttagg aaccgctggc ggactagaaa     1560



gaatgttgtc gtctgtgttc cggtggagga gctgtggaac ctgagtttcc agaaccccaa     1620



ccctagagag catttggggg tgctgtattg gagggggagg ctaaggaaag ttgggattgg     1680



gactggtggt gccaagataa gggtttctca aattggagaa cccctccttg ttgcatgagg     1740



tcaatggtca tcctgtctac ccaccctgcc tccaggccag ggggctgggg aggcaaatag     1800



agccccccta ttttagtctt tttaaaaaaa acatcctata ctaagggcag aacccactgc     1860



cccggcctca attaccttgg ctgaaggaaa gatggcggta ggagagaaaa gtgaagaggc     1920



gtgagtgtaa gaactgggag attccttttc cagcaggcct gggtagctgc cttcccagcc     1980



cagccctccc tggggcctgc gggagccctt ttgcatgcaa gggaggatgg aggctggccc     2040



ctctttatag aagcacattt ctgccacctc ccctgggagg cacccagaag cctgccactc     2100



tttacctagt ccctgctgtg tagggcgtag tccaggttag ctaggtagag ttagtgctcc     2160



aagccctggg gcctgttctt agctcatgca tagtccttac agagtcccag gaccgggggt     2220



ggagaggagc ctcaagtaca ttccaggaga ccactgtctc ctcgctggcc tgggcctaga     2280



tggggcagcc tggctcacag gaggccagcc cctcctcctc cgcccccttc cttcccttgt     2340



ccccgtaggg ttatagctgg agctgcctgt tatactcggc tgttctgatt tattattctt     2400



ggtactgact ttctttatga gggactccta agggttgtag gaccttggca gagggggcct     2460



ggtctccatt agagggtgtt gttttctcct gaggacaccc aggctgcctt tggtcccacc     2520



ctgttcctgg tcccggtccc ggtcccagtc ccaccaggca actccttcca cccggaaatt     2580



cttcccttcc cttagcctgt ggaaaccctg ggtattcttt aaagttctgg tcaatgtata     2640



tcacctccac agagctgctt accctgcact gggaagggga gatggagacg ccccctttac     2700



ccaggaggtc ttcagagttt cctgggaccg cggtgggtgg aatcccaagg ctgggggtgg     2760



aaggagcagg gctctggagg gattcgcatt caaggcacag aattggcccc ttgcctgttt     2820



gtttttctaa ccagtgtgat ttctctgctg ttcgtttatt acttaccatt ggaatatttt     2880



gagccaggag agcgccttct ctctccagcc atcaccgctg tggttgttca ggggtagctt     2940



ttcaaaaaca gggcagagcc tggctgtccc aaccaggggg agcaggggct tggccctgac     3000



agcctgagcc cttcccctgg tgtctgcaca gcctttataa agagagagag agctccgaag     3060



caataacaac acctgggggt ggtcagtgag ggccccctca atgattttct tgtttgttct     3120



gtgaaatccc gctcacctcc tggaggggtg gagcagctgg gggctggagc cctgtttctt     3180



tgtgtcatcg tgagcatgtg ccccttccca ggggctgtga ccattgggtg tgggaactac     3240



ggtctgtcct caccaaggga tgggggtttg gggaggagag tgacattttc atcattagct     3300



tcggagaagc ttcaagccca tcctgtcccc gctactgcct ggccccttgc tgactcaggc     3360



tgcactgttt gaagaggagc agagaggctg gcactagggg ccactggggg gctggggtct     3420



ccaggggatg actgttttca atctctgggc caagatcaca tgcaggatac cacgggaagg     3480



agccatctcc actctccttc tccagaaccc ccttgaaggg cctttgggac cattagtcca     3540



tttccatttt acagacaagg aaatcaagac ccagcttggg ggaaaagcca cccctggagt     3600



cacctgtgtg ttcagtggca cccccagcct gggtcccctc ctcccaatag aggctgagcc     3660



ggagccaggg cagtatgagg tggggctgcc actgcccata cctcctcctc ccttctttct     3720



ttgaagccta atggcccccc aaaagatggg caggacaagc tgtagcccat ctgagaggtt     3780



gggaaactga ggcccagaaa caggaagtga ctcacacaag acccctcagc aagggtgcaa     3840



agggggaaga actaggggct ccattgttct tcaggcgaca ggagaccgtt gctccagtgc     3900



atgtctgctg ggacaaggat tcctggcctc gaagccctgg gctgcacagc cctactgggc     3960



tccacctcta taaaccagtg acttctctgg gcctgggtct gggggagagg gttgccaggg     4020



agactcagct ctccttgggg gctggcccag ctgactgagg gtacacagga ttgggtctag     4080



accttgatgc ctgggtggag ggcccttgta aggggccata gcctcttcag gaccaactgg     4140



agggagagtt aggaaacacc agctcctgcc tggggcagtg agggaatggg agcagctgtg     4200



ggcgcctcat ttcaggcaag tcctccccaa accttcagat gcagtgagac ctggccttcc     4260



tgttgtgctt ttcagacttt gttttcagaa tgcttttatc tcgagtgtgc ccttcggccc     4320



tcacaagagc ccctggggag taggtggtgg cctgtgccgt catccccatt tcaaagcagg     4380



gagctgaggt cctgggaggg gaaagtgctt gcctgaggtc ccactgtgtt agtgggtggg     4440



caggactgga actcggttct ccaacagccc agagctcact cttttacacc cagaggtgga     4500



gcaggtggct tagggggtgg ttatgtactt cacaagccaa ttcccttcag ccaggagctc     4560



ctgggtgcat ttccgtgtca gaaacagtac cgagtcccac cccctctgga ggcacagctg     4620



ttgcgtcagg caaggtcacc tgcatttatt tattgagcag cagtgctgtg tcaggcccag     4680



ggaccgagcc cctctccctg ttcccctatg gtgtctccga ggccctctgg gagggcccca     4740



catctggagc agcacctcag agtggacaga aagcattagc gtccacgagc tcacccgacg     4800



ccgagcctgt gaggtgggct gatggtgccc gtctaaccca gcgcttcagg gaggtcagaa     4860



tggagccgaa cccagggctg tgagcatcac ctctggagcc ctttcacttt atgactgctt     4920



cctggacggg tggtgggaag gcaggagcct gggtccttag gctgggggcc tctctccatc     4980



cacccacctt tccctcattc cctctcttgg agcagcagcc gcccaggcct ttagggaggg     5040



agggtttctg gggcccttgg gttggagtgg ggtcgcgttg cattgtgttc atgaccatgt     5100



agctcatgtt gaaattaaag tttttggctt ttctaa                               5136





<210>  279

<211>  269

<212>  PRT

<213>  Homo sapiens



<400>  279



Met Glu Arg Ser Gln Ser Arg Leu Ser Leu Ser Ala Ser Phe Glu Ala 

1               5                   10                  15      





Leu Ala Ile Tyr Phe Pro Cys Met Asn Ser Phe Asp Asp Glu Asp Ala 

            20                  25                  30          





Gly Asp Ser Arg Arg Leu Lys Gly Ala Ile Gln Arg Ser Thr Glu Thr 

        35                  40                  45              





Gly Leu Ala Val Glu Met Pro Ser Arg Thr Leu Arg Gln Ala Ser His 

    50                  55                  60                  





Glu Ser Ile Glu Asp Ser Met Asn Ser Tyr Gly Ser Glu Gly Asn Leu 

65                  70                  75                  80  





Asn Tyr Gly Gly Val Cys Leu Ala Ser Asp Ala Gln Phe Ser Asp Phe 

                85                  90                  95      





Leu Gly Ser Met Gly Pro Ala Gln Phe Val Gly Arg Gln Thr Leu Ala 

            100                 105                 110         





Thr Thr Pro Met Gly Asp Val Glu Ile Gly Leu Gln Glu Arg Asn Gly 

        115                 120                 125             





Gln Leu Glu Val Asp Ile Ile Gln Ala Arg Gly Leu Thr Ala Lys Pro 

    130                 135                 140                 





Gly Ser Lys Thr Leu Pro Ala Ala Tyr Ile Lys Ala Tyr Leu Leu Glu 

145                 150                 155                 160 





Asn Gly Ile Cys Ile Ala Lys Lys Lys Thr Lys Val Ala Arg Lys Ser 

                165                 170                 175     





Leu Asp Pro Leu Tyr Asn Gln Val Leu Leu Phe Pro Glu Ser Pro Gln 

            180                 185                 190         





Gly Lys Val Leu Gln Val Ile Val Trp Gly Asn Tyr Gly Arg Met Glu 

        195                 200                 205             





Arg Lys Gln Phe Met Gly Val Ala Arg Val Leu Leu Glu Glu Leu Asp 

    210                 215                 220                 





Leu Thr Thr Leu Ala Val Gly Trp Tyr Lys Leu Phe Pro Thr Ser Ser 

225                 230                 235                 240 





Met Val Asp Pro Ala Thr Gly Pro Leu Leu Arg Gln Ala Ser Gln Leu 

                245                 250                 255     





Ser Leu Glu Ser Thr Val Gly Pro Cys Gly Glu Arg Ser 

            260                 265                 





<210>  280

<211>  2803

<212>  DNA

<213>  Homo sapiens



<400>  280

acacaagatg gcggcgccca gcggagtagg ggctgcgctt ggggtttgct gaagctggct       60



gcctctccca ctcccctttt gggtgcaaag cgccgctagc gggaagacgg gggccgggcg      120



gggacagggg cacctgcgta gctggactga gagcctgcgc ccagcttaca tcgaccccac      180



ccggccccgg cccgacccga cgcgacccga tccgatccga tcccattcca tccgttcctc      240



gtctcctccc ggtctgaccc gttgcccggc cgtggttcgc cacaccaggc atccaaagct      300



gaggtcgctc ctacggcctg ggctcgcctt cgctttagag atgtttggcc tcttccctcc      360



caaacagccc atcttcaaaa cctggactct tggactggca cctggccacc tttccctcta      420



ccaagactcc acttccgtct tacccacttc ttcctcagat tcttggtacc ccctgggttg      480



gagactgctc attttccttc caaattaatc ccagaccccc taaaatattg acaaccttga      540



caacccccca accgaggagc cagactttgt tttggactaa cttccatagc cctatcatgg      600



aggcagtgta cctggtagtg aatgggttgg gcctggtgct ggacgtgctg accttggtgt      660



tggacctcaa cttcctgctg gtgtcctccc tcctggcttc cctggcctgg ctcctggcct      720



tcgtctacaa cctgccgcac acggtactga ctagtcttct gcacttgggc cgcggagtct      780



tgctttcatt gctggccttg atcgaagccg tggtccggtt cacatgtggg ggcttgcagg      840



ccttgtgtac tctgctgtat agctgctgct ctggcctaga gagcctaaag ctcctggggc      900



acctggcctc tcatggggca ctgcggagca gggagatact gcaccggggc gtcctcaatg      960



tggtctccag tggccatgct ttgctgcgcc aggcctgtga catctgtgcc attgccatga     1020



gcctggtggc ttatgtgatc aacagcctgg tcaacatctg cctcatcggc actcagaacc     1080



tcttttccct ggtgctggcc ctgtgggatg cagtgaccgg gcctctgtgg aggatgacgg     1140



acgtagtggc tgccttccta gcccacattt ccagcagtgc tgtggccatg gccatcctcc     1200



tttggacacc ctgccaacta gccctggagc tgctggcctc agctgcccgc ctcctggcca     1260



gctttgtgct tgtcaatctc actggcttgg tgttgctagc ttgtgtgctg gcagtgacgg     1320



tgactgtgtt gcatccggac ttcaccctga ggctggctac ccaggcactc agccagctcc     1380



atgcccggcc atcctaccac cgtcttcgag aggatgtcat gcggctctct cgcctagcac     1440



tgggctcaga ggcctggcgc cgagtctgga gccgcagtct gcagctggcg agttggccaa     1500



accggggagg ggcacctgga gctccccagg gtgaccctat gagggtattc tcagttagga     1560



cccggagaca ggacactctt cctgaagcgg ggcgcagatc agaggcagaa gaggaggagg     1620



ccaggaccat cagagtgaca cctgtcaggg gccgagagag gctcaatgag gaggagcctc     1680



caggtgggca agacccttgg aaattgctga aggagcaaga ggagcggaag aagtgtgtca     1740



tctgccagga ccagagcaag acagtgttgc tcctgccctg ccggcatctg tgcctgtgcc     1800



aggcctgcac tgaaatcctg atgcgccacc ccgtctacca ccgcaattgc ccgctctgcc     1860



gccggggcat cctgcagacc ctcaatgtct acctctgaag cctccttccc tgcctgccca     1920



cccctccatg ctccacgcag gcactcacgc taggacagca ttaacacctc atctccgggt     1980



cctggtctga atcccctcct acccctgtgg ccatcctgcc atacatccag gacattgagt     2040



tggaagacta tgatctgggt gggggcagga taacatggct tctctttacc cagtgggtcc     2100



cttcgatgct gagggtggtg agtatgtcac tatgcaaggg ccctgagact atttgctgtg     2160



ggctctcctc cagcctgccc agggcccacc cagatgcctc tggggttacc cctgtctgct     2220



tctggttttt ctgttggaga tctataggtc cttttcctgc ctccttcaca tttcctcccc     2280



agcttttgcg gccacaacac atcagtgtca tttgggtgtt ttggcaactc aggggccttc     2340



ggatgatctt aaacctttgt gttcagccag agcccctgtg ccctggtagg cgttggggtt     2400



agtatctctc gggtgccctc agagccacct ctgcctgtga tcgtctgatg aggctccctc     2460



ccaacctgat ccaaaagcca gtctcaggag tttacccctg ggatggggga tgcatctgca     2520



cctgactttg gggccacgtg ccctgtggca ccccagctca ctgggagtct caggagggat     2580



aaccggattt ctgctctttc ccctgtcact cccacatcac acagaaaaat ggcattcctc     2640



tctgtctctc cctggcatgg agagggcaga ctgtgcacat ttcactaggg tccaaataca     2700



gaagggccca gggcccaggg gcttgcagct tcgtgagggg tctctggccc agtttccaat     2760



gaataaagtt ctcttgacag ctctgaaaaa aaaaaaaaaa aaa                       2803





<210>  281

<211>  433

<212>  PRT

<213>  Homo sapiens



<400>  281



Met Glu Ala Val Tyr Leu Val Val Asn Gly Leu Gly Leu Val Leu Asp 

1               5                   10                  15      





Val Leu Thr Leu Val Leu Asp Leu Asn Phe Leu Leu Val Ser Ser Leu 

            20                  25                  30          





Leu Ala Ser Leu Ala Trp Leu Leu Ala Phe Val Tyr Asn Leu Pro His 

        35                  40                  45              





Thr Val Leu Thr Ser Leu Leu His Leu Gly Arg Gly Val Leu Leu Ser 

    50                  55                  60                  





Leu Leu Ala Leu Ile Glu Ala Val Val Arg Phe Thr Cys Gly Gly Leu 

65                  70                  75                  80  





Gln Ala Leu Cys Thr Leu Leu Tyr Ser Cys Cys Ser Gly Leu Glu Ser 

                85                  90                  95      





Leu Lys Leu Leu Gly His Leu Ala Ser His Gly Ala Leu Arg Ser Arg 

            100                 105                 110         





Glu Ile Leu His Arg Gly Val Leu Asn Val Val Ser Ser Gly His Ala 

        115                 120                 125             





Leu Leu Arg Gln Ala Cys Asp Ile Cys Ala Ile Ala Met Ser Leu Val 

    130                 135                 140                 





Ala Tyr Val Ile Asn Ser Leu Val Asn Ile Cys Leu Ile Gly Thr Gln 

145                 150                 155                 160 





Asn Leu Phe Ser Leu Val Leu Ala Leu Trp Asp Ala Val Thr Gly Pro 

                165                 170                 175     





Leu Trp Arg Met Thr Asp Val Val Ala Ala Phe Leu Ala His Ile Ser 

            180                 185                 190         





Ser Ser Ala Val Ala Met Ala Ile Leu Leu Trp Thr Pro Cys Gln Leu 

        195                 200                 205             





Ala Leu Glu Leu Leu Ala Ser Ala Ala Arg Leu Leu Ala Ser Phe Val 

    210                 215                 220                 





Leu Val Asn Leu Thr Gly Leu Val Leu Leu Ala Cys Val Leu Ala Val 

225                 230                 235                 240 





Thr Val Thr Val Leu His Pro Asp Phe Thr Leu Arg Leu Ala Thr Gln 

                245                 250                 255     





Ala Leu Ser Gln Leu His Ala Arg Pro Ser Tyr His Arg Leu Arg Glu 

            260                 265                 270         





Asp Val Met Arg Leu Ser Arg Leu Ala Leu Gly Ser Glu Ala Trp Arg 

        275                 280                 285             





Arg Val Trp Ser Arg Ser Leu Gln Leu Ala Ser Trp Pro Asn Arg Gly 

    290                 295                 300                 





Gly Ala Pro Gly Ala Pro Gln Gly Asp Pro Met Arg Val Phe Ser Val 

305                 310                 315                 320 





Arg Thr Arg Arg Gln Asp Thr Leu Pro Glu Ala Gly Arg Arg Ser Glu 

                325                 330                 335     





Ala Glu Glu Glu Glu Ala Arg Thr Ile Arg Val Thr Pro Val Arg Gly 

            340                 345                 350         





Arg Glu Arg Leu Asn Glu Glu Glu Pro Pro Gly Gly Gln Asp Pro Trp 

        355                 360                 365             





Lys Leu Leu Lys Glu Gln Glu Glu Arg Lys Lys Cys Val Ile Cys Gln 

    370                 375                 380                 





Asp Gln Ser Lys Thr Val Leu Leu Leu Pro Cys Arg His Leu Cys Leu 

385                 390                 395                 400 





Cys Gln Ala Cys Thr Glu Ile Leu Met Arg His Pro Val Tyr His Arg 

                405                 410                 415     





Asn Cys Pro Leu Cys Arg Arg Gly Ile Leu Gln Thr Leu Asn Val Tyr 

            420                 425                 430         





Leu 

    





<210>  282

<211>  3569

<212>  DNA

<213>  Homo sapiens



<400>  282

atcctctctg actcctgaat cttctgctcc ttcctcctca agcaggttca cccgtacttg       60



tcaaaatggc tcaactcctg aatagcatac tcagtgtgat tgacgtattc cacaaatatg      120



ccaaagggaa tggggactgt gccttactat gcaaggaaga gttgaaacaa ctgctcttgg      180



ctgagtttgg agacatcctc cagagaccaa atgacccaga gactgtggaa accatcttga      240



acctcttaga tcaagaccga gatggacata ttgattttca tgagtacctc ttgttggtgt      300



tccagttggt ccaagcctgc tatcataagc tagacaataa gtcacatgga ggcaggacct      360



cacagcaaga aagggggcag gaaggagcac aagactgtaa gttcccagga aacacaggca      420



gacaacacag acagaggcac gaggaagaaa ggcagaactc ccaccacagt cagcctgaga      480



gacaagacgg agattcccac catggtcagc ctgagagaca agacagagat tcccaccatg      540



gtcagtctga gaaacaagac agagattccc accacagtca gcctgagaga caagacagag      600



attctcacca caatcagtct gagagacaag acaaggattt cagctttgat cagtcagaga      660



gacaaagtca agactccagc tctggtaaaa aagtgagtca caaatctacc agtggccagg      720



ctaaatggca gggacatatc tttgccttaa atcggtgtga aaaaccaatt caggattctc      780



attatggtca gtctgaaaga catacacaac aatctgaaac acttggacaa gcctctcact      840



ttaaccagac aaatcaacag aaatcaggct cttattgtgg acagtctgag aggctaggtc      900



aggaattagg ctgtggtcag acagacagac aaggccagag ttcccactac ggtcagacgg      960



acagacaaga ccagagttat cattatggtc agacagacag acaaggccag agttcccact     1020



acagtcagac ggacagacaa ggccagagtt cccactacag tcagccagac agacaaggtc     1080



agagttccca ctatggtcaa atggacagaa aaggccagtg ttatcattat gatcagacaa     1140



acagacaagg ccagggttcc cactacagtc aaccaaacag acaaggtcag agttcccact     1200



atggtcagcc agacacacaa gatcagagtt ctcactatgg tcagacagac agacaagacc     1260



aaagttctca ctatggtcag acagagagac aaggccagag ttcccactac agtcagatgg     1320



accgacaagg ccagggttct cactacggtc agacagacag acaaggccag agttcccact     1380



atggtcagcc agacagacaa ggccagaatt cccactatgg tcagacagac agacaaggcc     1440



agagttccca ctatggtcag acagacagac aaggccagag ttcccactac agtcagccag     1500



acaaacaagg ccagagttcc cactatggta agatagacag acaagaccag agttatcatt     1560



atggtcagcc agacggacaa ggccaaagtt cccactatgg tcagacagac agacaaggcc     1620



agagtttcca ctatggtcag ccagacagac aaggccagag ttcccactac agtcagatgg     1680



acagacaagg ccagagttcc cactatggtc agacagacag acaaggccag agttcccact     1740



acggtcagac agacagacaa ggccagagct atcattatgg tcagacagac agacaaggcc     1800



agagttccca ctatattcaa tcacagactg gggaaataca agggcaaaat aagtacttcc     1860



aagggactga aggaacaaga aaagcctctt atgttgaaca atcaggaaga tcagggaggc     1920



taagtcaaca gactccagga caggaagggt accaaaacca gggacaggga ttccagtcta     1980



gggactcaca gcagaacggc caccaggtat gggagcctga agaggatagc caacatcacc     2040



aacacaaact cttagcacaa atccaacaag aaagaccact ttgtcacaaa gggagagact     2100



ggcaatcatg cagtagtgag cagggccaca gacaggccca gaccaggcag agtcatggtg     2160



aggggctgag ccactgggca gaggaagagc agggccatca aacttgggat agacacagcc     2220



atgagagtca ggaaggtcca tgtgggacac aggacaggcg aacccataaa gatgagcaga     2280



accatcagag acgagacaga caaacccatg aacatgagca gagccatcag agacgagaca     2340



ggcaaaccca tgaagacaag cagaaccgtc agagacgaga caggcaaacc catgaagacg     2400



agcagaacca tcagagatga gacaggcaaa ctcatgaaga ggatcaaaac catcagcaac     2460



aacataatag acaaaactat gaggagaaag agaggtatca aggatctcag aatcaaaaat     2520



cccaagtgac ccacagaagc tgtcctaaca gagaaaaatt ccacatgaaa gaggatgacc     2580



agagccaagg ctcacagaaa agacacactg aaccatcctt ctatccaacc cagagcagtg     2640



ggaggcccca aaccagagaa cagcgtggtc accctgccaa gggagctact gttcccaacc     2700



ccccctatga ctatgtgcaa gagcagaaat cctacccata ctaggctatg tgagcaccag     2760



aggtaaagca acacaaagcc aaaaaagaaa cctatatgtc gagttcacct ttaattcgat     2820



ttaagagatt gagaatgtat ttcttccctc tatcctctgc tgtatctccc tgcaaggatg     2880



tttttgagta ctagcattca cgtaagggct tttggttctt tgagcagcaa ttctagggtt     2940



ttctgattca gtgaaatcta ggtggtaaat tgggtgaaat aatcatatct taatgttgat     3000



cagtttgggt atttaaatca tttcctgctt tgccctctgt gtagatgaga cctggttgaa     3060



tcattgaaag gtagaacact tctccctaaa gttcagaaac agaaaagata ttctgaagat     3120



ttacattaca tccaaggatt atactacatc tccactcctc aaggaaccct agatttggtg     3180



agctttggct cctgtggata aaacatcagg aatttcaagc ctcatagtct agactagaat     3240



gaaactcagt tcaaggctgc tacaagagcc gagaacatag agtgcatctc tgatgtttac     3300



tacatctccc atgccaggct cttattccac accagaggga ctgtccatta gtgcctatca     3360



ctagagctga atggacccat tccaattcaa tacctttcta gtttctgatt atataaaata     3420



aagagaaagt atatgtcata tgtttgcaaa ttccagggga tcaagactat tgattcatag     3480



ctcctaagac ctgaaaactc ttctcaagaa aatctatgtg cagattatga attgtattaa     3540



aatatctaat aaataattga tgagcaata                                       3569





<210>  283

<211>  784

<212>  PRT

<213>  Homo sapiens



<400>  283



Met Ala Gln Leu Leu Asn Ser Ile Leu Ser Val Ile Asp Val Phe His 

1               5                   10                  15      





Lys Tyr Ala Lys Gly Asn Gly Asp Cys Ala Leu Leu Cys Lys Glu Glu 

            20                  25                  30          





Leu Lys Gln Leu Leu Leu Ala Glu Phe Gly Asp Ile Leu Gln Arg Pro 

        35                  40                  45              





Asn Asp Pro Glu Thr Val Glu Thr Ile Leu Asn Leu Leu Asp Gln Asp 

    50                  55                  60                  





Arg Asp Gly His Ile Asp Phe His Glu Tyr Leu Leu Leu Val Phe Gln 

65                  70                  75                  80  





Leu Val Gln Ala Cys Tyr His Lys Leu Asp Asn Lys Ser His Gly Gly 

                85                  90                  95      





Arg Thr Ser Gln Gln Glu Arg Gly Gln Glu Gly Ala Gln Asp Cys Lys 

            100                 105                 110         





Phe Pro Gly Asn Thr Gly Arg Gln His Arg Gln Arg His Glu Glu Glu 

        115                 120                 125             





Arg Gln Asn Ser His His Ser Gln Pro Glu Arg Gln Asp Gly Asp Ser 

    130                 135                 140                 





His His Gly Gln Pro Glu Arg Gln Asp Arg Asp Ser His His Gly Gln 

145                 150                 155                 160 





Ser Glu Lys Gln Asp Arg Asp Ser His His Ser Gln Pro Glu Arg Gln 

                165                 170                 175     





Asp Arg Asp Ser His His Asn Gln Ser Glu Arg Gln Asp Lys Asp Phe 

            180                 185                 190         





Ser Phe Asp Gln Ser Glu Arg Gln Ser Gln Asp Ser Ser Ser Gly Lys 

        195                 200                 205             





Lys Val Ser His Lys Ser Thr Ser Gly Gln Ala Lys Trp Gln Gly His 

    210                 215                 220                 





Ile Phe Ala Leu Asn Arg Cys Glu Lys Pro Ile Gln Asp Ser His Tyr 

225                 230                 235                 240 





Gly Gln Ser Glu Arg His Thr Gln Gln Ser Glu Thr Leu Gly Gln Ala 

                245                 250                 255     





Ser His Phe Asn Gln Thr Asn Gln Gln Lys Ser Gly Ser Tyr Cys Gly 

            260                 265                 270         





Gln Ser Glu Arg Leu Gly Gln Glu Leu Gly Cys Gly Gln Thr Asp Arg 

        275                 280                 285             





Gln Gly Gln Ser Ser His Tyr Gly Gln Thr Asp Arg Gln Asp Gln Ser 

    290                 295                 300                 





Tyr His Tyr Gly Gln Thr Asp Arg Gln Gly Gln Ser Ser His Tyr Ser 

305                 310                 315                 320 





Gln Thr Asp Arg Gln Gly Gln Ser Ser His Tyr Ser Gln Pro Asp Arg 

                325                 330                 335     





Gln Gly Gln Ser Ser His Tyr Gly Gln Met Asp Arg Lys Gly Gln Cys 

            340                 345                 350         





Tyr His Tyr Asp Gln Thr Asn Arg Gln Gly Gln Gly Ser His Tyr Ser 

        355                 360                 365             





Gln Pro Asn Arg Gln Gly Gln Ser Ser His Tyr Gly Gln Pro Asp Thr 

    370                 375                 380                 





Gln Asp Gln Ser Ser His Tyr Gly Gln Thr Asp Arg Gln Asp Gln Ser 

385                 390                 395                 400 





Ser His Tyr Gly Gln Thr Glu Arg Gln Gly Gln Ser Ser His Tyr Ser 

                405                 410                 415     





Gln Met Asp Arg Gln Gly Gln Gly Ser His Tyr Gly Gln Thr Asp Arg 

            420                 425                 430         





Gln Gly Gln Ser Ser His Tyr Gly Gln Pro Asp Arg Gln Gly Gln Asn 

        435                 440                 445             





Ser His Tyr Gly Gln Thr Asp Arg Gln Gly Gln Ser Ser His Tyr Gly 

    450                 455                 460                 





Gln Thr Asp Arg Gln Gly Gln Ser Ser His Tyr Ser Gln Pro Asp Lys 

465                 470                 475                 480 





Gln Gly Gln Ser Ser His Tyr Gly Lys Ile Asp Arg Gln Asp Gln Ser 

                485                 490                 495     





Tyr His Tyr Gly Gln Pro Asp Gly Gln Gly Gln Ser Ser His Tyr Gly 

            500                 505                 510         





Gln Thr Asp Arg Gln Gly Gln Ser Phe His Tyr Gly Gln Pro Asp Arg 

        515                 520                 525             





Gln Gly Gln Ser Ser His Tyr Ser Gln Met Asp Arg Gln Gly Gln Ser 

    530                 535                 540                 





Ser His Tyr Gly Gln Thr Asp Arg Gln Gly Gln Ser Ser His Tyr Gly 

545                 550                 555                 560 





Gln Thr Asp Arg Gln Gly Gln Ser Tyr His Tyr Gly Gln Thr Asp Arg 

                565                 570                 575     





Gln Gly Gln Ser Ser His Tyr Ile Gln Ser Gln Thr Gly Glu Ile Gln 

            580                 585                 590         





Gly Gln Asn Lys Tyr Phe Gln Gly Thr Glu Gly Thr Arg Lys Ala Ser 

        595                 600                 605             





Tyr Val Glu Gln Ser Gly Arg Ser Gly Arg Leu Ser Gln Gln Thr Pro 

    610                 615                 620                 





Gly Gln Glu Gly Tyr Gln Asn Gln Gly Gln Gly Phe Gln Ser Arg Asp 

625                 630                 635                 640 





Ser Gln Gln Asn Gly His Gln Val Trp Glu Pro Glu Glu Asp Ser Gln 

                645                 650                 655     





His His Gln His Lys Leu Leu Ala Gln Ile Gln Gln Glu Arg Pro Leu 

            660                 665                 670         





Cys His Lys Gly Arg Asp Trp Gln Ser Cys Ser Ser Glu Gln Gly His 

        675                 680                 685             





Arg Gln Ala Gln Thr Arg Gln Ser His Gly Glu Gly Leu Ser His Trp 

    690                 695                 700                 





Ala Glu Glu Glu Gln Gly His Gln Thr Trp Asp Arg His Ser His Glu 

705                 710                 715                 720 





Ser Gln Glu Gly Pro Cys Gly Thr Gln Asp Arg Arg Thr His Lys Asp 

                725                 730                 735     





Glu Gln Asn His Gln Arg Arg Asp Arg Gln Thr His Glu His Glu Gln 

            740                 745                 750         





Ser His Gln Arg Arg Asp Arg Gln Thr His Glu Asp Lys Gln Asn Arg 

        755                 760                 765             





Gln Arg Arg Asp Arg Gln Thr His Glu Asp Glu Gln Asn His Gln Arg 

    770                 775                 780                 





<210>  284

<211>  3032

<212>  DNA

<213>  Homo sapiens



<400>  284

gtcacccgta acaaccacaa gtgccgtcgc cgcgcccctt ccccctcccg cctccccggc       60



cccctccccg gaaccggcgg tcgagctacg gtcgcggagc agtggaaccg agactgcccc      120



gcggagccgc cggtatgagc gcccctcgcc accccgtgtc ccaggcccgg cctttctgac      180



aagagctaga cttcgggctc cttgaggata ttcagttttg tatgtttgaa tatcctctca      240



ccatgttcag cataaagtac cattcttaat gattatcctc aacaagacag gtgtgagagg      300



gttgctgttg tattgcaatc atggtgcaga aataccagtc cccagtgagg gtgtacaaat      360



acccctttga attaattatg gctgcctatg aaaggaggtt ccctacatgt cctttgattc      420



cgatgttcgt gggcagtgac actgtgaatg aattcaagag cgaagatggg gctattcatg      480



tcattgaaag gcgctgcaag ctggatgtag atgcacccag actgctgaag aagattgcag      540



gagttgatta tgtttatttt gtccagaaaa actcactgaa ttctcgggaa cgtactttgc      600



acattgaggc ttataatgaa acgttttcca atcgggtcat cattaatgag cattgctgct      660



acaccgttca ccctgaaaat gaagattgga cctgttttga acagtctgca agtttagata      720



ttaaatcttt ctttggtttt gaaagtacag tggaaaaaat tgcaatgaaa caatatacca      780



gcaacattaa aaaaggaaag gaaatcatcg aatactacct tcgccaatta gaagaagaag      840



gcataacctt tgtgccccgt tggagtccgc cttccatcac gccctcttca gagacatctt      900



catcatcctc caagaaacaa gcagcgtcca tggccgtcgt catcccagaa gctgccctca      960



aggaggggct gagtggtgat gccctcagca gccccagcgc acctgagccc gtggtgggca     1020



cccctgacga caaactagat gccgactaca tcaagagata cctgggcgat ttgactccgc     1080



tgcaggagag ctgcctcatt agacttcgcc agtggctcca ggagacccac aagggcaaaa     1140



ttccaaaaga tgagcatatt cttcggttcc tccgtgcacg ggattttaat attgacaaag     1200



ccagagagat catgtgtcag tctttgacgt ggagaaagca gcatcaggta gactacattc     1260



ttgaaacctg gacccctcct caggtccttc aggattacta cgcgggaggc tggcatcatc     1320



acgacaaaga tgggcggccc ctctacgtgc tcaggctggg gcagatggac accaaaggct     1380



tggtgagagc gctcggggag gaagccctgc tgagatacgt tctctccata aatgaagaag     1440



ggctaaggcg atgcgaagag aatacaaaag tctttggtcg gcctatcagc tcatggacct     1500



gcctggtgga cttggaaggg ctgaacatgc gccacttgtg gagacctggt gtgaaagcgc     1560



tgctgcggat catcgaggtg gtggaggcca actaccctga gacactgggc cgccttctca     1620



tcctgcgggc gcccagggta tttcctgtgc tctggacgct ggttagtccg ttcattgatg     1680



acaacaccag aaggaagttc ctcatttatg caggaaatga ctaccagggt cctggaggcc     1740



tgctggatta catcgacaaa gagattattc cagatttcct gagtggggag tgcatgtgcg     1800



aagtgccaga gggtggactg gtccccaaat ctctgtaccg gactgcagag gagctggaga     1860



acgaagacct gaagctctgg actgagacca tctaccagtc tgcaagcgtc ttcaaaggag     1920



ccccacatga gattctcatt cagattgtgg atgcctcgtc agtcatcact tgggatttcg     1980



acgtgtgcaa aggggacatt gtgtttaaca tctatcactc caagaggtcg ccacaaccac     2040



ccaaaaagga ctccctggga gcccacagca tcacctctcc gggtgggaac aatgtgcagc     2100



tcatagacaa agtctggcag ctgggccgcg actacagcat ggtggagtcg cctctgatct     2160



gcaaagaagg agaaagcgtg cagggttccc atgtgaccag gtggccgggc ttctacatcc     2220



tgcagtggaa attccacagc atgcctgcgt gcgccgccag cagccttccc cgggtggacg     2280



acgtgcttgc gtccctgcag gtctcttcgc acaagtgtaa agtgatgtac tacaccgagg     2340



tgatcggctc ggaggatttc agaggttcca tgacgagcct ggagtccagc cacagcggct     2400



tctcccagct gagtgccgcc accacctcct ccagccagtc ccactccagc tccatgatct     2460



ccagatggcg attttgctga cagctgccaa gaaaatgctt cactcaacag tcctcatgtg     2520



cccagagatg tttatagaac tgtttgaatt gcagccatcc cctgccccct cccaggctga     2580



agatctgttc tttttaagtt gattcgggag tggcattctt ttatacccaa agactgtagt     2640



gcatcttgaa gagctcaaag cacatgaccg cacaaatgct tacagggttt cctcccgagt     2700



aatccaatct cactcccctt gtaagggaat tctggggcag ctatggtttg agtatgcagt     2760



ttgcatcgtg tttctacctt tagtaccttg ccactctttt aaaacgctgc tgtcatttcc     2820



catttcttag tactaatgat tctttgattc tccctctatt atgtcttaat tcactttcct     2880



tcctaaattt gttatttgca tatcaaattc tgtaaatgtt ttgtaaacat attacctcac     2940



ttggtaatac aatactgata gtctttaaaa gattttttta ttgttatcaa taataaatgt     3000



gaactattta aagaaaaaaa aaaaaaaaaa aa                                   3032





<210>  285

<211>  719

<212>  PRT

<213>  Homo sapiens



<400>  285



Met Val Gln Lys Tyr Gln Ser Pro Val Arg Val Tyr Lys Tyr Pro Phe 

1               5                   10                  15      





Glu Leu Ile Met Ala Ala Tyr Glu Arg Arg Phe Pro Thr Cys Pro Leu 

            20                  25                  30          





Ile Pro Met Phe Val Gly Ser Asp Thr Val Asn Glu Phe Lys Ser Glu 

        35                  40                  45              





Asp Gly Ala Ile His Val Ile Glu Arg Arg Cys Lys Leu Asp Val Asp 

    50                  55                  60                  





Ala Pro Arg Leu Leu Lys Lys Ile Ala Gly Val Asp Tyr Val Tyr Phe 

65                  70                  75                  80  





Val Gln Lys Asn Ser Leu Asn Ser Arg Glu Arg Thr Leu His Ile Glu 

                85                  90                  95      





Ala Tyr Asn Glu Thr Phe Ser Asn Arg Val Ile Ile Asn Glu His Cys 

            100                 105                 110         





Cys Tyr Thr Val His Pro Glu Asn Glu Asp Trp Thr Cys Phe Glu Gln 

        115                 120                 125             





Ser Ala Ser Leu Asp Ile Lys Ser Phe Phe Gly Phe Glu Ser Thr Val 

    130                 135                 140                 





Glu Lys Ile Ala Met Lys Gln Tyr Thr Ser Asn Ile Lys Lys Gly Lys 

145                 150                 155                 160 





Glu Ile Ile Glu Tyr Tyr Leu Arg Gln Leu Glu Glu Glu Gly Ile Thr 

                165                 170                 175     





Phe Val Pro Arg Trp Ser Pro Pro Ser Ile Thr Pro Ser Ser Glu Thr 

            180                 185                 190         





Ser Ser Ser Ser Ser Lys Lys Gln Ala Ala Ser Met Ala Val Val Ile 

        195                 200                 205             





Pro Glu Ala Ala Leu Lys Glu Gly Leu Ser Gly Asp Ala Leu Ser Ser 

    210                 215                 220                 





Pro Ser Ala Pro Glu Pro Val Val Gly Thr Pro Asp Asp Lys Leu Asp 

225                 230                 235                 240 





Ala Asp Tyr Ile Lys Arg Tyr Leu Gly Asp Leu Thr Pro Leu Gln Glu 

                245                 250                 255     





Ser Cys Leu Ile Arg Leu Arg Gln Trp Leu Gln Glu Thr His Lys Gly 

            260                 265                 270         





Lys Ile Pro Lys Asp Glu His Ile Leu Arg Phe Leu Arg Ala Arg Asp 

        275                 280                 285             





Phe Asn Ile Asp Lys Ala Arg Glu Ile Met Cys Gln Ser Leu Thr Trp 

    290                 295                 300                 





Arg Lys Gln His Gln Val Asp Tyr Ile Leu Glu Thr Trp Thr Pro Pro 

305                 310                 315                 320 





Gln Val Leu Gln Asp Tyr Tyr Ala Gly Gly Trp His His His Asp Lys 

                325                 330                 335     





Asp Gly Arg Pro Leu Tyr Val Leu Arg Leu Gly Gln Met Asp Thr Lys 

            340                 345                 350         





Gly Leu Val Arg Ala Leu Gly Glu Glu Ala Leu Leu Arg Tyr Val Leu 

        355                 360                 365             





Ser Ile Asn Glu Glu Gly Leu Arg Arg Cys Glu Glu Asn Thr Lys Val 

    370                 375                 380                 





Phe Gly Arg Pro Ile Ser Ser Trp Thr Cys Leu Val Asp Leu Glu Gly 

385                 390                 395                 400 





Leu Asn Met Arg His Leu Trp Arg Pro Gly Val Lys Ala Leu Leu Arg 

                405                 410                 415     





Ile Ile Glu Val Val Glu Ala Asn Tyr Pro Glu Thr Leu Gly Arg Leu 

            420                 425                 430         





Leu Ile Leu Arg Ala Pro Arg Val Phe Pro Val Leu Trp Thr Leu Val 

        435                 440                 445             





Ser Pro Phe Ile Asp Asp Asn Thr Arg Arg Lys Phe Leu Ile Tyr Ala 

    450                 455                 460                 





Gly Asn Asp Tyr Gln Gly Pro Gly Gly Leu Leu Asp Tyr Ile Asp Lys 

465                 470                 475                 480 





Glu Ile Ile Pro Asp Phe Leu Ser Gly Glu Cys Met Cys Glu Val Pro 

                485                 490                 495     





Glu Gly Gly Leu Val Pro Lys Ser Leu Tyr Arg Thr Ala Glu Glu Leu 

            500                 505                 510         





Glu Asn Glu Asp Leu Lys Leu Trp Thr Glu Thr Ile Tyr Gln Ser Ala 

        515                 520                 525             





Ser Val Phe Lys Gly Ala Pro His Glu Ile Leu Ile Gln Ile Val Asp 

    530                 535                 540                 





Ala Ser Ser Val Ile Thr Trp Asp Phe Asp Val Cys Lys Gly Asp Ile 

545                 550                 555                 560 





Val Phe Asn Ile Tyr His Ser Lys Arg Ser Pro Gln Pro Pro Lys Lys 

                565                 570                 575     





Asp Ser Leu Gly Ala His Ser Ile Thr Ser Pro Gly Gly Asn Asn Val 

            580                 585                 590         





Gln Leu Ile Asp Lys Val Trp Gln Leu Gly Arg Asp Tyr Ser Met Val 

        595                 600                 605             





Glu Ser Pro Leu Ile Cys Lys Glu Gly Glu Ser Val Gln Gly Ser His 

    610                 615                 620                 





Val Thr Arg Trp Pro Gly Phe Tyr Ile Leu Gln Trp Lys Phe His Ser 

625                 630                 635                 640 





Met Pro Ala Cys Ala Ala Ser Ser Leu Pro Arg Val Asp Asp Val Leu 

                645                 650                 655     





Ala Ser Leu Gln Val Ser Ser His Lys Cys Lys Val Met Tyr Tyr Thr 

            660                 665                 670         





Glu Val Ile Gly Ser Glu Asp Phe Arg Gly Ser Met Thr Ser Leu Glu 

        675                 680                 685             





Ser Ser His Ser Gly Phe Ser Gln Leu Ser Ala Ala Thr Thr Ser Ser 

    690                 695                 700                 





Ser Gln Ser His Ser Ser Ser Met Ile Ser Arg Trp Arg Phe Cys 

705                 710                 715                 





<210>  286

<211>  5546

<212>  DNA

<213>  Homo sapiens



<400>  286

gtcacccgta acaaccacaa gtgccgtcgc cgcgcccctt ccccctcccg cctccccggc       60



cccctccccg gaaccggcgg tcgagctacg gtcgcggagc agtggaaccg agactgcccc      120



gcggagccgc cggtatgagc gcccctcgcc accccgtgtc ccaggcccgg cctttctgac      180



aagagctaga cttcgggctc cttgaggata ttcagttttg tatgtttgaa tatcctctca      240



ccatgttcag cataaagtac cattcttaat gattatcctc aacaagacag gtgtgagagg      300



gttgctgttg tattgcaatc atggtgcaga aataccagtc cccagtgagg gtgtacaaat      360



acccctttga attaattatg gctgcctatg aaaggaggtt ccctacatgt cctttgattc      420



cgatgttcgt gggcagtgac actgtgaatg aattcaagag cgaagatggg gctattcatg      480



tcattgaaag gcgctgcaag ctggatgtag atgcacccag actgctgaag aagattgcag      540



gagttgatta tgtttatttt gtccagaaaa actcactgaa ttctcgggaa cgtactttgc      600



acattgaggc ttataatgaa acgttttcca atcgggtcat cattaatgag cattgctgct      660



acaccgttca ccctgaaaat gaagattgga cctgttttga acagtctgca agtttagata      720



ttaaatcttt ctttggtttt gaaagtacag tggaaaaaat tgcaatgaaa caatatacca      780



gcaacattaa aaaaggaaag gaaatcatcg aatactacct tcgccaatta gaagaagaag      840



gcataacctt tgtgccccgt tggagtccgc cttccatcac gccctcttca gagacatctt      900



catcatcctc caagaaacaa gcagcgtcca tggccgtcgt catcccagaa gctgccctca      960



aggaggggct gagtggtgat gccctcagca gccccagcgc acctgagccc gtggtgggca     1020



cccctgacga caaactagat gccgactaca tcaagagata cctgggcgat ttgactccgc     1080



tgcaggagag ctgcctcatt agacttcgcc agtggctcca ggagacccac aagggcaaaa     1140



ttccaaaaga tgagcatatt cttcggttcc tccgtgcacg ggattttaat attgacaaag     1200



ccagagagat catgtgtcag tctttgacgt ggagaaagca gcatcaggta gactacattc     1260



ttgaaacctg gacccctcct caggtccttc aggattacta cgcgggaggc tggcatcatc     1320



acgacaaaga tgggcggccc ctctacgtgc tcaggctggg gcagatggac accaaaggct     1380



tggtgagagc gctcggggag gaagccctgc tgagatacgt tctctccata aatgaagaag     1440



ggctaaggcg atgcgaagag aatacaaaag tctttggtcg gcctatcagc tcatggacct     1500



gcctggtgga cttggaaggg ctgaacatgc gccacttgtg gagacctggt gtgaaagcgc     1560



tgctgcggat catcgaggtg gtggaggcca actaccctga gacactgggc cgccttctca     1620



tcctgcgggc gcccagggta tttcctgtgc tctggacgct ggttagtccg ttcattgatg     1680



acaacaccag aaggaagttc ctcatttatg caggaaatga ctaccagggt cctggaggcc     1740



tgctggatta catcgacaaa gagattattc cagatttcct gagtggggag tgcatgtgcg     1800



aagtgccaga gggtggactg gtccccaaat ctctgtaccg gactgcagag gagctggaga     1860



acgaagacct gaagctctgg actgagacca tctaccagtc tgcaagcgtc ttcaaaggag     1920



ccccacatga gattctcatt cagattgtgg atgcctcgtc agtcatcact tgggatttcg     1980



acgtgtgcaa aggggacatt gtgtttaaca tctatcactc caagaggtcg ccacaaccac     2040



ccaaaaagga ctccctggga gcccacagca tcacctctcc gggtgggaac aatgtgcagc     2100



tcatagacaa agtctggcag ctgggccgcg actacagcat ggtggagtcg cctctgatct     2160



gcaaagaagg agaaagcgtg cagggttccc atgtgaccag gtggccgggc ttctacatcc     2220



tgcagtggaa attccacagc atgcctgcgt gcgccgccag cagccttccc cgggtggacg     2280



acgtgcttgc gtccctgcag gtctcttcgc acaagtgtaa agtgatgtac tacaccgagg     2340



tgatcggctc ggaggatttc agaggttcca tgacgagcct ggagtccagc cacagcggct     2400



tctcccagct gagtgccgcc accacctcct ccagccagtc ccactccagc tccatgatct     2460



ccaggtagtg ccgcgctgcc tgcacctagt gtgcagaggg gacggccgcc cctcctcgga     2520



cagccagctg cacccgccca cccagcggcg acattgtaca gactcctctc acctctagat     2580



agcaaatagc tctcagatgg taaacgtagt cgtttgatcc caaaactacc ttggcaggta     2640



gttttaactc tgatcctaac ttaactcaat agccatagat tttgtatacg ttgtgcacaa     2700



aatccaacca gagcgcaagg gctctcttga aagaaaagta gtttctgtac caattaaagg     2760



attgacgtgg tctcagatat tgatgcaaaa aatttttcca acgaactccg cattgtccat     2820



tagtgaatga attcctgtga catcctccag agatggcccc tcctcacctg ggacggaagc     2880



tgccagctcg cttcccccaa gctgcctcat ggcccgcacg ccgcctcacg gcccccatgc     2940



ttcccgccag tcaagatggt ctgtggactt agggccagcc cttgaggtcc ttatcctctg     3000



aggattcaga ggttgcctgc ggagtacctt gtcccagggc cagacacacc cacaccaccc     3060



actgtcctgc agtggggccg ggggctcagg aggggctctc agggactcct ggtgactcca     3120



ggaaaatgct gccatcgtta aacattactt tctctttcct ccttttcaaa tctttttgat     3180



actttttaga gcaggatttt tctgtatgtg aacttgggtg ggggggttct tcccgtttcc     3240



ttccgtgcgt cgcccctctc acctgcagtc agctcccagc ccagtgtagg ccatctcctc     3300



tgtgccctct ggtggctcat tgtcctcaga gcccagacag ttccagccac taggaggccg     3360



tcttggaacc agcaagtcgc atttgccact tgacactgtc catggggttt tattagtagc     3420



taagcagcag ctctcgcatc cacttcaggg tggcgtgtgg catgtaggag tcctgcttct     3480



ttgtacatgg gaattgtgga ctcatgcgtg tgtgtgtgtg catgtgctgt gtgtgtgcat     3540



gtgtgcatga cggtgggggt gctgggggga cggggtgagt ggaaacttag tttgagtaat     3600



gaaggaatct tcacagaagc aaatcagaat atgggatttg tttgcctttt acattttgtt     3660



taattcctga ttttaaagcc tgctctatct ggtacaggcc cttatttttt cagcttttta     3720



tgggaaaagc aggttatttg agaatctgtc cagaagttgc ataggggatg gcctccacga     3780



taaggacatg caacacgtgt ttctgtgtgc agcagaggcc gtgtttttca tgccaaaccc     3840



cacgcggctg tcaactgtgt gcgtggtagg catggagatc ctggttgtgc cgtctcagct     3900



ccgctctgaa ggcactgtgt gggtgctgcg tgactggaga gctgtgtgga ggccatgtgt     3960



gccccgtgca gggatcagga gggcggggga gggaccgagc agccctcttg cccggtcggg     4020



tcagccctag tggctgcctg cacactgtag acgtcccagg gcctgtgctg tgatcacctg     4080



cctttggacc acatttgtgt ttgctcttag agatcgagct cctcagtggt acctgaagcc     4140



tttgcttccg gaaagcgcgg tagggttcgt aggtagggct agtaggtagg gttagtaggt     4200



agggctagta ggtagggcta gtaggtaggg ttcgtaggta gggttcgtag gtagggctgg     4260



taggtagggt tagtaggtag ggctagtagg tagggttagt aggtagggtt cgtaggtagg     4320



gttcgtaggt agggttcgta ggtagggcta gtaggtaggg ttagtaggta gggttcgtag     4380



gtagggttcg taggtagggt taggtagggt tcgtaggtag ggttagtagg tagggctagt     4440



aggtagggtt cgtaggtagg gttcgtaggt agggctagta ggtagggtta gtaggtaggg     4500



ctagtaggta gggctagtag gtagggttag taggtagggc tagtaggtag ggttcgtagg     4560



tagggttagt aggtagggct agtaggtagg gttcgtaggt agggttcgta ggtagggcta     4620



gtaggtaggg ttagtaggta gggctagtag gtagggctag taggtagggt tcgtaggtag     4680



ggttcgtagg tagggttcgt aggtagggtt cgtaggtagg gttagtaggt agggttcgta     4740



ggtagggcta gtaggtaggg ctagtaggta gggctagtag gtagggttag taggtagggc     4800



tagtaggtag ggctagtagg tagggctagt aggtagggct agtaggtagg gttcgtaggt     4860



agggttcgta ggtagggttc gtaggtaggg ttagtagcgc gtctgtgctg cttccacctg     4920



gtgcttcctg ttcccaaatc acaagggcct gaaggtggtc cctgctttct ctttctcttt     4980



ctctgtgtct cagatggcga ttttgctgac agctgccaag aaaatgcttc actcaacagt     5040



cctcatgtgc ccagagatgt ttatagaact gtttgaattg cagccatccc ctgccccctc     5100



ccaggctgaa gatctgttct ttttaagttg attcgggagt ggcattcttt tatacccaaa     5160



gactgtagtg catcttgaag agctcaaagc acatgaccgc acaaatgctt acagggtttc     5220



ctcccgagta atccaatctc actccccttg taagggaatt ctggggcagc tatggtttga     5280



gtatgcagtt tgcatcgtgt ttctaccttt agtaccttgc cactctttta aaacgctgct     5340



gtcatttccc atttcttagt actaatgatt ctttgattct ccctctatta tgtcttaatt     5400



cactttcctt cctaaatttg ttatttgcat atcaaattct gtaaatgttt tgtaaacata     5460



ttacctcact tggtaataca atactgatag tctttaaaag atttttttat tgttatcaat     5520



aataaatgtg aactatttaa agaaaa                                          5546





<210>  287

<211>  715

<212>  PRT

<213>  Homo sapiens



<400>  287



Met Val Gln Lys Tyr Gln Ser Pro Val Arg Val Tyr Lys Tyr Pro Phe 

1               5                   10                  15      





Glu Leu Ile Met Ala Ala Tyr Glu Arg Arg Phe Pro Thr Cys Pro Leu 

            20                  25                  30          





Ile Pro Met Phe Val Gly Ser Asp Thr Val Asn Glu Phe Lys Ser Glu 

        35                  40                  45              





Asp Gly Ala Ile His Val Ile Glu Arg Arg Cys Lys Leu Asp Val Asp 

    50                  55                  60                  





Ala Pro Arg Leu Leu Lys Lys Ile Ala Gly Val Asp Tyr Val Tyr Phe 

65                  70                  75                  80  





Val Gln Lys Asn Ser Leu Asn Ser Arg Glu Arg Thr Leu His Ile Glu 

                85                  90                  95      





Ala Tyr Asn Glu Thr Phe Ser Asn Arg Val Ile Ile Asn Glu His Cys 

            100                 105                 110         





Cys Tyr Thr Val His Pro Glu Asn Glu Asp Trp Thr Cys Phe Glu Gln 

        115                 120                 125             





Ser Ala Ser Leu Asp Ile Lys Ser Phe Phe Gly Phe Glu Ser Thr Val 

    130                 135                 140                 





Glu Lys Ile Ala Met Lys Gln Tyr Thr Ser Asn Ile Lys Lys Gly Lys 

145                 150                 155                 160 





Glu Ile Ile Glu Tyr Tyr Leu Arg Gln Leu Glu Glu Glu Gly Ile Thr 

                165                 170                 175     





Phe Val Pro Arg Trp Ser Pro Pro Ser Ile Thr Pro Ser Ser Glu Thr 

            180                 185                 190         





Ser Ser Ser Ser Ser Lys Lys Gln Ala Ala Ser Met Ala Val Val Ile 

        195                 200                 205             





Pro Glu Ala Ala Leu Lys Glu Gly Leu Ser Gly Asp Ala Leu Ser Ser 

    210                 215                 220                 





Pro Ser Ala Pro Glu Pro Val Val Gly Thr Pro Asp Asp Lys Leu Asp 

225                 230                 235                 240 





Ala Asp Tyr Ile Lys Arg Tyr Leu Gly Asp Leu Thr Pro Leu Gln Glu 

                245                 250                 255     





Ser Cys Leu Ile Arg Leu Arg Gln Trp Leu Gln Glu Thr His Lys Gly 

            260                 265                 270         





Lys Ile Pro Lys Asp Glu His Ile Leu Arg Phe Leu Arg Ala Arg Asp 

        275                 280                 285             





Phe Asn Ile Asp Lys Ala Arg Glu Ile Met Cys Gln Ser Leu Thr Trp 

    290                 295                 300                 





Arg Lys Gln His Gln Val Asp Tyr Ile Leu Glu Thr Trp Thr Pro Pro 

305                 310                 315                 320 





Gln Val Leu Gln Asp Tyr Tyr Ala Gly Gly Trp His His His Asp Lys 

                325                 330                 335     





Asp Gly Arg Pro Leu Tyr Val Leu Arg Leu Gly Gln Met Asp Thr Lys 

            340                 345                 350         





Gly Leu Val Arg Ala Leu Gly Glu Glu Ala Leu Leu Arg Tyr Val Leu 

        355                 360                 365             





Ser Ile Asn Glu Glu Gly Leu Arg Arg Cys Glu Glu Asn Thr Lys Val 

    370                 375                 380                 





Phe Gly Arg Pro Ile Ser Ser Trp Thr Cys Leu Val Asp Leu Glu Gly 

385                 390                 395                 400 





Leu Asn Met Arg His Leu Trp Arg Pro Gly Val Lys Ala Leu Leu Arg 

                405                 410                 415     





Ile Ile Glu Val Val Glu Ala Asn Tyr Pro Glu Thr Leu Gly Arg Leu 

            420                 425                 430         





Leu Ile Leu Arg Ala Pro Arg Val Phe Pro Val Leu Trp Thr Leu Val 

        435                 440                 445             





Ser Pro Phe Ile Asp Asp Asn Thr Arg Arg Lys Phe Leu Ile Tyr Ala 

    450                 455                 460                 





Gly Asn Asp Tyr Gln Gly Pro Gly Gly Leu Leu Asp Tyr Ile Asp Lys 

465                 470                 475                 480 





Glu Ile Ile Pro Asp Phe Leu Ser Gly Glu Cys Met Cys Glu Val Pro 

                485                 490                 495     





Glu Gly Gly Leu Val Pro Lys Ser Leu Tyr Arg Thr Ala Glu Glu Leu 

            500                 505                 510         





Glu Asn Glu Asp Leu Lys Leu Trp Thr Glu Thr Ile Tyr Gln Ser Ala 

        515                 520                 525             





Ser Val Phe Lys Gly Ala Pro His Glu Ile Leu Ile Gln Ile Val Asp 

    530                 535                 540                 





Ala Ser Ser Val Ile Thr Trp Asp Phe Asp Val Cys Lys Gly Asp Ile 

545                 550                 555                 560 





Val Phe Asn Ile Tyr His Ser Lys Arg Ser Pro Gln Pro Pro Lys Lys 

                565                 570                 575     





Asp Ser Leu Gly Ala His Ser Ile Thr Ser Pro Gly Gly Asn Asn Val 

            580                 585                 590         





Gln Leu Ile Asp Lys Val Trp Gln Leu Gly Arg Asp Tyr Ser Met Val 

        595                 600                 605             





Glu Ser Pro Leu Ile Cys Lys Glu Gly Glu Ser Val Gln Gly Ser His 

    610                 615                 620                 





Val Thr Arg Trp Pro Gly Phe Tyr Ile Leu Gln Trp Lys Phe His Ser 

625                 630                 635                 640 





Met Pro Ala Cys Ala Ala Ser Ser Leu Pro Arg Val Asp Asp Val Leu 

                645                 650                 655     





Ala Ser Leu Gln Val Ser Ser His Lys Cys Lys Val Met Tyr Tyr Thr 

            660                 665                 670         





Glu Val Ile Gly Ser Glu Asp Phe Arg Gly Ser Met Thr Ser Leu Glu 

        675                 680                 685             





Ser Ser His Ser Gly Phe Ser Gln Leu Ser Ala Ala Thr Thr Ser Ser 

    690                 695                 700                 





Ser Gln Ser His Ser Ser Ser Met Ile Ser Arg 

705                 710                 715 





<210>  288

<211>  5542

<212>  DNA

<213>  Homo sapiens



<400>  288

gtcacccgta acaaccacaa gtgccgtcgc cgcgcccctt ccccctcccg cctccccggc       60



cccctccccg gaaccggcgg tcgagctacg gtcgcggagc agtggaaccg agactgcccc      120



gcggagccgc cggtatgagc gcccctcgcc accccgtgtc ccaggcccgg cctttctgac      180



aagagacttc gggctccttg aggatattca gttttgtatg tttgaatatc ctctcaccat      240



gttcagcata aagtaccatt cttaatgatt atcctcaaca agacaggtgt gagagggttg      300



ctgttgtatt gcaatcatgg tgcagaaata ccagtcccca gtgagggtgt acaaataccc      360



ctttgaatta attatggctg cctatgaaag gaggttccct acatgtcctt tgattccgat      420



gttcgtgggc agtgacactg tgaatgaatt caagagcgaa gatggggcta ttcatgtcat      480



tgaaaggcgc tgcaagctgg atgtagatgc acccagactg ctgaagaaga ttgcaggagt      540



tgattatgtt tattttgtcc agaaaaactc actgaattct cgggaacgta ctttgcacat      600



tgaggcttat aatgaaacgt tttccaatcg ggtcatcatt aatgagcatt gctgctacac      660



cgttcaccct gaaaatgaag attggacctg ttttgaacag tctgcaagtt tagatattaa      720



atctttcttt ggttttgaaa gtacagtgga aaaaattgca atgaaacaat ataccagcaa      780



cattaaaaaa ggaaaggaaa tcatcgaata ctaccttcgc caattagaag aagaaggcat      840



aacctttgtg ccccgttgga gtccgccttc catcacgccc tcttcagaga catcttcatc      900



atcctccaag aaacaagcag cgtccatggc cgtcgtcatc ccagaagctg ccctcaagga      960



ggggctgagt ggtgatgccc tcagcagccc cagcgcacct gagcccgtgg tgggcacccc     1020



tgacgacaaa ctagatgccg actacatcaa gagatacctg ggcgatttga ctccgctgca     1080



ggagagctgc ctcattagac ttcgccagtg gctccaggag acccacaagg gcaaaattcc     1140



aaaagatgag catattcttc ggttcctccg tgcacgggat tttaatattg acaaagccag     1200



agagatcatg tgtcagtctt tgacgtggag aaagcagcat caggtagact acattcttga     1260



aacctggacc cctcctcagg tccttcagga ttactacgcg ggaggctggc atcatcacga     1320



caaagatggg cggcccctct acgtgctcag gctggggcag atggacacca aaggcttggt     1380



gagagcgctc ggggaggaag ccctgctgag atacgttctc tccataaatg aagaagggct     1440



aaggcgatgc gaagagaata caaaagtctt tggtcggcct atcagctcat ggacctgcct     1500



ggtggacttg gaagggctga acatgcgcca cttgtggaga cctggtgtga aagcgctgct     1560



gcggatcatc gaggtggtgg aggccaacta ccctgagaca ctgggccgcc ttctcatcct     1620



gcgggcgccc agggtatttc ctgtgctctg gacgctggtt agtccgttca ttgatgacaa     1680



caccagaagg aagttcctca tttatgcagg aaatgactac cagggtcctg gaggcctgct     1740



ggattacatc gacaaagaga ttattccaga tttcctgagt ggggagtgca tgtgcgaagt     1800



gccagagggt ggactggtcc ccaaatctct gtaccggact gcagaggagc tggagaacga     1860



agacctgaag ctctggactg agaccatcta ccagtctgca agcgtcttca aaggagcccc     1920



acatgagatt ctcattcaga ttgtggatgc ctcgtcagtc atcacttggg atttcgacgt     1980



gtgcaaaggg gacattgtgt ttaacatcta tcactccaag aggtcgccac aaccacccaa     2040



aaaggactcc ctgggagccc acagcatcac ctctccgggt gggaacaatg tgcagctcat     2100



agacaaagtc tggcagctgg gccgcgacta cagcatggtg gagtcgcctc tgatctgcaa     2160



agaaggagaa agcgtgcagg gttcccatgt gaccaggtgg ccgggcttct acatcctgca     2220



gtggaaattc cacagcatgc ctgcgtgcgc cgccagcagc cttccccggg tggacgacgt     2280



gcttgcgtcc ctgcaggtct cttcgcacaa gtgtaaagtg atgtactaca ccgaggtgat     2340



cggctcggag gatttcagag gttccatgac gagcctggag tccagccaca gcggcttctc     2400



ccagctgagt gccgccacca cctcctccag ccagtcccac tccagctcca tgatctccag     2460



gtagtgccgc gctgcctgca cctagtgtgc agaggggacg gccgcccctc ctcggacagc     2520



cagctgcacc cgcccaccca gcggcgacat tgtacagact cctctcacct ctagatagca     2580



aatagctctc agatggtaaa cgtagtcgtt tgatcccaaa actaccttgg caggtagttt     2640



taactctgat cctaacttaa ctcaatagcc atagattttg tatacgttgt gcacaaaatc     2700



caaccagagc gcaagggctc tcttgaaaga aaagtagttt ctgtaccaat taaaggattg     2760



acgtggtctc agatattgat gcaaaaaatt tttccaacga actccgcatt gtccattagt     2820



gaatgaattc ctgtgacatc ctccagagat ggcccctcct cacctgggac ggaagctgcc     2880



agctcgcttc ccccaagctg cctcatggcc cgcacgccgc ctcacggccc ccatgcttcc     2940



cgccagtcaa gatggtctgt ggacttaggg ccagcccttg aggtccttat cctctgagga     3000



ttcagaggtt gcctgcggag taccttgtcc cagggccaga cacacccaca ccacccactg     3060



tcctgcagtg gggccggggg ctcaggaggg gctctcaggg actcctggtg actccaggaa     3120



aatgctgcca tcgttaaaca ttactttctc tttcctcctt ttcaaatctt tttgatactt     3180



tttagagcag gatttttctg tatgtgaact tgggtggggg ggttcttccc gtttccttcc     3240



gtgcgtcgcc cctctcacct gcagtcagct cccagcccag tgtaggccat ctcctctgtg     3300



ccctctggtg gctcattgtc ctcagagccc agacagttcc agccactagg aggccgtctt     3360



ggaaccagca agtcgcattt gccacttgac actgtccatg gggttttatt agtagctaag     3420



cagcagctct cgcatccact tcagggtggc gtgtggcatg taggagtcct gcttctttgt     3480



acatgggaat tgtggactca tgcgtgtgtg tgtgtgcatg tgctgtgtgt gtgcatgtgt     3540



gcatgacggt gggggtgctg gggggacggg gtgagtggaa acttagtttg agtaatgaag     3600



gaatcttcac agaagcaaat cagaatatgg gatttgtttg ccttttacat tttgtttaat     3660



tcctgatttt aaagcctgct ctatctggta caggccctta ttttttcagc tttttatggg     3720



aaaagcaggt tatttgagaa tctgtccaga agttgcatag gggatggcct ccacgataag     3780



gacatgcaac acgtgtttct gtgtgcagca gaggccgtgt ttttcatgcc aaaccccacg     3840



cggctgtcaa ctgtgtgcgt ggtaggcatg gagatcctgg ttgtgccgtc tcagctccgc     3900



tctgaaggca ctgtgtgggt gctgcgtgac tggagagctg tgtggaggcc atgtgtgccc     3960



cgtgcaggga tcaggagggc gggggaggga ccgagcagcc ctcttgcccg gtcgggtcag     4020



ccctagtggc tgcctgcaca ctgtagacgt cccagggcct gtgctgtgat cacctgcctt     4080



tggaccacat ttgtgtttgc tcttagagat cgagctcctc agtggtacct gaagcctttg     4140



cttccggaaa gcgcggtagg gttcgtaggt agggctagta ggtagggtta gtaggtaggg     4200



ctagtaggta gggctagtag gtagggttcg taggtagggt tcgtaggtag ggctggtagg     4260



tagggttagt aggtagggct agtaggtagg gttagtaggt agggttcgta ggtagggttc     4320



gtaggtaggg ttcgtaggta gggctagtag gtagggttag taggtagggt tcgtaggtag     4380



ggttcgtagg tagggttagg tagggttcgt aggtagggtt agtaggtagg gctagtaggt     4440



agggttcgta ggtagggttc gtaggtaggg ctagtaggta gggttagtag gtagggctag     4500



taggtagggc tagtaggtag ggttagtagg tagggctagt aggtagggtt cgtaggtagg     4560



gttagtaggt agggctagta ggtagggttc gtaggtaggg ttcgtaggta gggctagtag     4620



gtagggttag taggtagggc tagtaggtag ggctagtagg tagggttcgt aggtagggtt     4680



cgtaggtagg gttcgtaggt agggttcgta ggtagggtta gtaggtaggg ttcgtaggta     4740



gggctagtag gtagggctag taggtagggc tagtaggtag ggttagtagg tagggctagt     4800



aggtagggct agtaggtagg gctagtaggt agggctagta ggtagggttc gtaggtaggg     4860



ttcgtaggta gggttcgtag gtagggttag tagcgcgtct gtgctgcttc cacctggtgc     4920



ttcctgttcc caaatcacaa gggcctgaag gtggtccctg ctttctcttt ctctttctct     4980



gtgtctcaga tggcgatttt gctgacagct gccaagaaaa tgcttcactc aacagtcctc     5040



atgtgcccag agatgtttat agaactgttt gaattgcagc catcccctgc cccctcccag     5100



gctgaagatc tgttcttttt aagttgattc gggagtggca ttcttttata cccaaagact     5160



gtagtgcatc ttgaagagct caaagcacat gaccgcacaa atgcttacag ggtttcctcc     5220



cgagtaatcc aatctcactc cccttgtaag ggaattctgg ggcagctatg gtttgagtat     5280



gcagtttgca tcgtgtttct acctttagta ccttgccact cttttaaaac gctgctgtca     5340



tttcccattt cttagtacta atgattcttt gattctccct ctattatgtc ttaattcact     5400



ttccttccta aatttgttat ttgcatatca aattctgtaa atgttttgta aacatattac     5460



ctcacttggt aatacaatac tgatagtctt taaaagattt ttttattgtt atcaataata     5520



aatgtgaact atttaaagaa aa                                              5542





<210>  289

<211>  715

<212>  PRT

<213>  Homo sapiens



<400>  289



Met Val Gln Lys Tyr Gln Ser Pro Val Arg Val Tyr Lys Tyr Pro Phe 

1               5                   10                  15      





Glu Leu Ile Met Ala Ala Tyr Glu Arg Arg Phe Pro Thr Cys Pro Leu 

            20                  25                  30          





Ile Pro Met Phe Val Gly Ser Asp Thr Val Asn Glu Phe Lys Ser Glu 

        35                  40                  45              





Asp Gly Ala Ile His Val Ile Glu Arg Arg Cys Lys Leu Asp Val Asp 

    50                  55                  60                  





Ala Pro Arg Leu Leu Lys Lys Ile Ala Gly Val Asp Tyr Val Tyr Phe 

65                  70                  75                  80  





Val Gln Lys Asn Ser Leu Asn Ser Arg Glu Arg Thr Leu His Ile Glu 

                85                  90                  95      





Ala Tyr Asn Glu Thr Phe Ser Asn Arg Val Ile Ile Asn Glu His Cys 

            100                 105                 110         





Cys Tyr Thr Val His Pro Glu Asn Glu Asp Trp Thr Cys Phe Glu Gln 

        115                 120                 125             





Ser Ala Ser Leu Asp Ile Lys Ser Phe Phe Gly Phe Glu Ser Thr Val 

    130                 135                 140                 





Glu Lys Ile Ala Met Lys Gln Tyr Thr Ser Asn Ile Lys Lys Gly Lys 

145                 150                 155                 160 





Glu Ile Ile Glu Tyr Tyr Leu Arg Gln Leu Glu Glu Glu Gly Ile Thr 

                165                 170                 175     





Phe Val Pro Arg Trp Ser Pro Pro Ser Ile Thr Pro Ser Ser Glu Thr 

            180                 185                 190         





Ser Ser Ser Ser Ser Lys Lys Gln Ala Ala Ser Met Ala Val Val Ile 

        195                 200                 205             





Pro Glu Ala Ala Leu Lys Glu Gly Leu Ser Gly Asp Ala Leu Ser Ser 

    210                 215                 220                 





Pro Ser Ala Pro Glu Pro Val Val Gly Thr Pro Asp Asp Lys Leu Asp 

225                 230                 235                 240 





Ala Asp Tyr Ile Lys Arg Tyr Leu Gly Asp Leu Thr Pro Leu Gln Glu 

                245                 250                 255     





Ser Cys Leu Ile Arg Leu Arg Gln Trp Leu Gln Glu Thr His Lys Gly 

            260                 265                 270         





Lys Ile Pro Lys Asp Glu His Ile Leu Arg Phe Leu Arg Ala Arg Asp 

        275                 280                 285             





Phe Asn Ile Asp Lys Ala Arg Glu Ile Met Cys Gln Ser Leu Thr Trp 

    290                 295                 300                 





Arg Lys Gln His Gln Val Asp Tyr Ile Leu Glu Thr Trp Thr Pro Pro 

305                 310                 315                 320 





Gln Val Leu Gln Asp Tyr Tyr Ala Gly Gly Trp His His His Asp Lys 

                325                 330                 335     





Asp Gly Arg Pro Leu Tyr Val Leu Arg Leu Gly Gln Met Asp Thr Lys 

            340                 345                 350         





Gly Leu Val Arg Ala Leu Gly Glu Glu Ala Leu Leu Arg Tyr Val Leu 

        355                 360                 365             





Ser Ile Asn Glu Glu Gly Leu Arg Arg Cys Glu Glu Asn Thr Lys Val 

    370                 375                 380                 





Phe Gly Arg Pro Ile Ser Ser Trp Thr Cys Leu Val Asp Leu Glu Gly 

385                 390                 395                 400 





Leu Asn Met Arg His Leu Trp Arg Pro Gly Val Lys Ala Leu Leu Arg 

                405                 410                 415     





Ile Ile Glu Val Val Glu Ala Asn Tyr Pro Glu Thr Leu Gly Arg Leu 

            420                 425                 430         





Leu Ile Leu Arg Ala Pro Arg Val Phe Pro Val Leu Trp Thr Leu Val 

        435                 440                 445             





Ser Pro Phe Ile Asp Asp Asn Thr Arg Arg Lys Phe Leu Ile Tyr Ala 

    450                 455                 460                 





Gly Asn Asp Tyr Gln Gly Pro Gly Gly Leu Leu Asp Tyr Ile Asp Lys 

465                 470                 475                 480 





Glu Ile Ile Pro Asp Phe Leu Ser Gly Glu Cys Met Cys Glu Val Pro 

                485                 490                 495     





Glu Gly Gly Leu Val Pro Lys Ser Leu Tyr Arg Thr Ala Glu Glu Leu 

            500                 505                 510         





Glu Asn Glu Asp Leu Lys Leu Trp Thr Glu Thr Ile Tyr Gln Ser Ala 

        515                 520                 525             





Ser Val Phe Lys Gly Ala Pro His Glu Ile Leu Ile Gln Ile Val Asp 

    530                 535                 540                 





Ala Ser Ser Val Ile Thr Trp Asp Phe Asp Val Cys Lys Gly Asp Ile 

545                 550                 555                 560 





Val Phe Asn Ile Tyr His Ser Lys Arg Ser Pro Gln Pro Pro Lys Lys 

                565                 570                 575     





Asp Ser Leu Gly Ala His Ser Ile Thr Ser Pro Gly Gly Asn Asn Val 

            580                 585                 590         





Gln Leu Ile Asp Lys Val Trp Gln Leu Gly Arg Asp Tyr Ser Met Val 

        595                 600                 605             





Glu Ser Pro Leu Ile Cys Lys Glu Gly Glu Ser Val Gln Gly Ser His 

    610                 615                 620                 





Val Thr Arg Trp Pro Gly Phe Tyr Ile Leu Gln Trp Lys Phe His Ser 

625                 630                 635                 640 





Met Pro Ala Cys Ala Ala Ser Ser Leu Pro Arg Val Asp Asp Val Leu 

                645                 650                 655     





Ala Ser Leu Gln Val Ser Ser His Lys Cys Lys Val Met Tyr Tyr Thr 

            660                 665                 670         





Glu Val Ile Gly Ser Glu Asp Phe Arg Gly Ser Met Thr Ser Leu Glu 

        675                 680                 685             





Ser Ser His Ser Gly Phe Ser Gln Leu Ser Ala Ala Thr Thr Ser Ser 

    690                 695                 700                 





Ser Gln Ser His Ser Ser Ser Met Ile Ser Arg 

705                 710                 715 





<210>  290

<211>  5334

<212>  DNA

<213>  Homo sapiens



<400>  290

agtgcatttg gtggcagagt gacaggcttg gaagagaatg tggagggagt aagggaggcg       60



cttgctaact gcccctgacg ctgacagagc tctggagagg tcagtgcagc ttctgagtta      120



gctgctcctt agcctggata ccttaaatgc catctggttg ggcatgccaa ggcctatgaa      180



aggaggttcc ctacatgtcc tttgattccg atgttcgtgg gcagtgacac tgtgaatgaa      240



ttcaagagcg aagatggggc tattcatgtc attgaaaggc gctgcaagct ggatgtagat      300



gcacccagac tgctgaagaa gattgcagga gttgattatg tttattttgt ccagaaaaac      360



tcactgaatt ctcgggaacg tactttgcac attgaggctt ataatgaaac gttttccaat      420



cgggtcatca ttaatgagca ttgctgctac accgttcacc ctgaaaatga agattggacc      480



tgttttgaac agtctgcaag tttagatatt aaatctttct ttggttttga aagtacagtg      540



gaaaaaattg caatgaaaca atataccagc aacattaaaa aaggaaagga aatcatcgaa      600



tactaccttc gccaattaga agaagaaggc ataacctttg tgccccgttg gagtccgcct      660



tccatcacgc cctcttcaga gacatcttca tcatcctcca agaaacaagc agcgtccatg      720



gccgtcgtca tcccagaagc tgccctcaag gaggggctga gtggtgatgc cctcagcagc      780



cccagcgcac ctgagcccgt ggtgggcacc cctgacgaca aactagatgc cgactacatc      840



aagagatacc tgggcgattt gactccgctg caggagagct gcctcattag acttcgccag      900



tggctccagg agacccacaa gggcaaaatt ccaaaagatg agcatattct tcggttcctc      960



cgtgcacggg attttaatat tgacaaagcc agagagatca tgtgtcagtc tttgacgtgg     1020



agaaagcagc atcaggtaga ctacattctt gaaacctgga cccctcctca ggtccttcag     1080



gattactacg cgggaggctg gcatcatcac gacaaagatg ggcggcccct ctacgtgctc     1140



aggctggggc agatggacac caaaggcttg gtgagagcgc tcggggagga agccctgctg     1200



agatacgttc tctccataaa tgaagaaggg ctaaggcgat gcgaagagaa tacaaaagtc     1260



tttggtcggc ctatcagctc atggacctgc ctggtggact tggaagggct gaacatgcgc     1320



cacttgtgga gacctggtgt gaaagcgctg ctgcggatca tcgaggtggt ggaggccaac     1380



taccctgaga cactgggccg ccttctcatc ctgcgggcgc ccagggtatt tcctgtgctc     1440



tggacgctgg ttagtccgtt cattgatgac aacaccagaa ggaagttcct catttatgca     1500



ggaaatgact accagggtcc tggaggcctg ctggattaca tcgacaaaga gattattcca     1560



gatttcctga gtggggagtg catgtgcgaa gtgccagagg gtggactggt ccccaaatct     1620



ctgtaccgga ctgcagagga gctggagaac gaagacctga agctctggac tgagaccatc     1680



taccagtctg caagcgtctt caaaggagcc ccacatgaga ttctcattca gattgtggat     1740



gcctcgtcag tcatcacttg ggatttcgac gtgtgcaaag gggacattgt gtttaacatc     1800



tatcactcca agaggtcgcc acaaccaccc aaaaaggact ccctgggagc ccacagcatc     1860



acctctccgg gtgggaacaa tgtgcagctc atagacaaag tctggcagct gggccgcgac     1920



tacagcatgg tggagtcgcc tctgatctgc aaagaaggag aaagcgtgca gggttcccat     1980



gtgaccaggt ggccgggctt ctacatcctg cagtggaaat tccacagcat gcctgcgtgc     2040



gccgccagca gccttccccg ggtggacgac gtgcttgcgt ccctgcaggt ctcttcgcac     2100



aagtgtaaag tgatgtacta caccgaggtg atcggctcgg aggatttcag aggttccatg     2160



acgagcctgg agtccagcca cagcggcttc tcccagctga gtgccgccac cacctcctcc     2220



agccagtccc actccagctc catgatctcc aggtagtgcc gcgctgcctg cacctagtgt     2280



gcagagggga cggccgcccc tcctcggaca gccagctgca cccgcccacc cagcggcgac     2340



attgtacaga ctcctctcac ctctagatag caaatagctc tcagatggta aacgtagtcg     2400



tttgatccca aaactacctt ggcaggtagt tttaactctg atcctaactt aactcaatag     2460



ccatagattt tgtatacgtt gtgcacaaaa tccaaccaga gcgcaagggc tctcttgaaa     2520



gaaaagtagt ttctgtacca attaaaggat tgacgtggtc tcagatattg atgcaaaaaa     2580



tttttccaac gaactccgca ttgtccatta gtgaatgaat tcctgtgaca tcctccagag     2640



atggcccctc ctcacctggg acggaagctg ccagctcgct tcccccaagc tgcctcatgg     2700



cccgcacgcc gcctcacggc ccccatgctt cccgccagtc aagatggtct gtggacttag     2760



ggccagccct tgaggtcctt atcctctgag gattcagagg ttgcctgcgg agtaccttgt     2820



cccagggcca gacacaccca caccacccac tgtcctgcag tggggccggg ggctcaggag     2880



gggctctcag ggactcctgg tgactccagg aaaatgctgc catcgttaaa cattactttc     2940



tctttcctcc ttttcaaatc tttttgatac tttttagagc aggatttttc tgtatgtgaa     3000



cttgggtggg ggggttcttc ccgtttcctt ccgtgcgtcg cccctctcac ctgcagtcag     3060



ctcccagccc agtgtaggcc atctcctctg tgccctctgg tggctcattg tcctcagagc     3120



ccagacagtt ccagccacta ggaggccgtc ttggaaccag caagtcgcat ttgccacttg     3180



acactgtcca tggggtttta ttagtagcta agcagcagct ctcgcatcca cttcagggtg     3240



gcgtgtggca tgtaggagtc ctgcttcttt gtacatggga attgtggact catgcgtgtg     3300



tgtgtgtgca tgtgctgtgt gtgtgcatgt gtgcatgacg gtgggggtgc tggggggacg     3360



gggtgagtgg aaacttagtt tgagtaatga aggaatcttc acagaagcaa atcagaatat     3420



gggatttgtt tgccttttac attttgttta attcctgatt ttaaagcctg ctctatctgg     3480



tacaggccct tattttttca gctttttatg ggaaaagcag gttatttgag aatctgtcca     3540



gaagttgcat aggggatggc ctccacgata aggacatgca acacgtgttt ctgtgtgcag     3600



cagaggccgt gtttttcatg ccaaacccca cgcggctgtc aactgtgtgc gtggtaggca     3660



tggagatcct ggttgtgccg tctcagctcc gctctgaagg cactgtgtgg gtgctgcgtg     3720



actggagagc tgtgtggagg ccatgtgtgc cccgtgcagg gatcaggagg gcgggggagg     3780



gaccgagcag ccctcttgcc cggtcgggtc agccctagtg gctgcctgca cactgtagac     3840



gtcccagggc ctgtgctgtg atcacctgcc tttggaccac atttgtgttt gctcttagag     3900



atcgagctcc tcagtggtac ctgaagcctt tgcttccgga aagcgcggta gggttcgtag     3960



gtagggctag taggtagggt tagtaggtag ggctagtagg tagggctagt aggtagggtt     4020



cgtaggtagg gttcgtaggt agggctggta ggtagggtta gtaggtaggg ctagtaggta     4080



gggttagtag gtagggttcg taggtagggt tcgtaggtag ggttcgtagg tagggctagt     4140



aggtagggtt agtaggtagg gttcgtaggt agggttcgta ggtagggtta ggtagggttc     4200



gtaggtaggg ttagtaggta gggctagtag gtagggttcg taggtagggt tcgtaggtag     4260



ggctagtagg tagggttagt aggtagggct agtaggtagg gctagtaggt agggttagta     4320



ggtagggcta gtaggtaggg ttcgtaggta gggttagtag gtagggctag taggtagggt     4380



tcgtaggtag ggttcgtagg tagggctagt aggtagggtt agtaggtagg gctagtaggt     4440



agggctagta ggtagggttc gtaggtaggg ttcgtaggta gggttcgtag gtagggttcg     4500



taggtagggt tagtaggtag ggttcgtagg tagggctagt aggtagggct agtaggtagg     4560



gctagtaggt agggttagta ggtagggcta gtaggtaggg ctagtaggta gggctagtag     4620



gtagggctag taggtagggt tcgtaggtag ggttcgtagg tagggttcgt aggtagggtt     4680



agtagcgcgt ctgtgctgct tccacctggt gcttcctgtt cccaaatcac aagggcctga     4740



aggtggtccc tgctttctct ttctctttct ctgtgtctca gatggcgatt ttgctgacag     4800



ctgccaagaa aatgcttcac tcaacagtcc tcatgtgccc agagatgttt atagaactgt     4860



ttgaattgca gccatcccct gccccctccc aggctgaaga tctgttcttt ttaagttgat     4920



tcgggagtgg cattctttta tacccaaaga ctgtagtgca tcttgaagag ctcaaagcac     4980



atgaccgcac aaatgcttac agggtttcct cccgagtaat ccaatctcac tccccttgta     5040



agggaattct ggggcagcta tggtttgagt atgcagtttg catcgtgttt ctacctttag     5100



taccttgcca ctcttttaaa acgctgctgt catttcccat ttcttagtac taatgattct     5160



ttgattctcc ctctattatg tcttaattca ctttccttcc taaatttgtt atttgcatat     5220



caaattctgt aaatgttttg taaacatatt acctcacttg gtaatacaat actgatagtc     5280



tttaaaagat ttttttattg ttatcaataa taaatgtgaa ctatttaaag aaaa           5334





<210>  291

<211>  681

<212>  PRT

<213>  Homo sapiens



<400>  291



Met Phe Val Gly Ser Asp Thr Val Asn Glu Phe Lys Ser Glu Asp Gly 

1               5                   10                  15      





Ala Ile His Val Ile Glu Arg Arg Cys Lys Leu Asp Val Asp Ala Pro 

            20                  25                  30          





Arg Leu Leu Lys Lys Ile Ala Gly Val Asp Tyr Val Tyr Phe Val Gln 

        35                  40                  45              





Lys Asn Ser Leu Asn Ser Arg Glu Arg Thr Leu His Ile Glu Ala Tyr 

    50                  55                  60                  





Asn Glu Thr Phe Ser Asn Arg Val Ile Ile Asn Glu His Cys Cys Tyr 

65                  70                  75                  80  





Thr Val His Pro Glu Asn Glu Asp Trp Thr Cys Phe Glu Gln Ser Ala 

                85                  90                  95      





Ser Leu Asp Ile Lys Ser Phe Phe Gly Phe Glu Ser Thr Val Glu Lys 

            100                 105                 110         





Ile Ala Met Lys Gln Tyr Thr Ser Asn Ile Lys Lys Gly Lys Glu Ile 

        115                 120                 125             





Ile Glu Tyr Tyr Leu Arg Gln Leu Glu Glu Glu Gly Ile Thr Phe Val 

    130                 135                 140                 





Pro Arg Trp Ser Pro Pro Ser Ile Thr Pro Ser Ser Glu Thr Ser Ser 

145                 150                 155                 160 





Ser Ser Ser Lys Lys Gln Ala Ala Ser Met Ala Val Val Ile Pro Glu 

                165                 170                 175     





Ala Ala Leu Lys Glu Gly Leu Ser Gly Asp Ala Leu Ser Ser Pro Ser 

            180                 185                 190         





Ala Pro Glu Pro Val Val Gly Thr Pro Asp Asp Lys Leu Asp Ala Asp 

        195                 200                 205             





Tyr Ile Lys Arg Tyr Leu Gly Asp Leu Thr Pro Leu Gln Glu Ser Cys 

    210                 215                 220                 





Leu Ile Arg Leu Arg Gln Trp Leu Gln Glu Thr His Lys Gly Lys Ile 

225                 230                 235                 240 





Pro Lys Asp Glu His Ile Leu Arg Phe Leu Arg Ala Arg Asp Phe Asn 

                245                 250                 255     





Ile Asp Lys Ala Arg Glu Ile Met Cys Gln Ser Leu Thr Trp Arg Lys 

            260                 265                 270         





Gln His Gln Val Asp Tyr Ile Leu Glu Thr Trp Thr Pro Pro Gln Val 

        275                 280                 285             





Leu Gln Asp Tyr Tyr Ala Gly Gly Trp His His His Asp Lys Asp Gly 

    290                 295                 300                 





Arg Pro Leu Tyr Val Leu Arg Leu Gly Gln Met Asp Thr Lys Gly Leu 

305                 310                 315                 320 





Val Arg Ala Leu Gly Glu Glu Ala Leu Leu Arg Tyr Val Leu Ser Ile 

                325                 330                 335     





Asn Glu Glu Gly Leu Arg Arg Cys Glu Glu Asn Thr Lys Val Phe Gly 

            340                 345                 350         





Arg Pro Ile Ser Ser Trp Thr Cys Leu Val Asp Leu Glu Gly Leu Asn 

        355                 360                 365             





Met Arg His Leu Trp Arg Pro Gly Val Lys Ala Leu Leu Arg Ile Ile 

    370                 375                 380                 





Glu Val Val Glu Ala Asn Tyr Pro Glu Thr Leu Gly Arg Leu Leu Ile 

385                 390                 395                 400 





Leu Arg Ala Pro Arg Val Phe Pro Val Leu Trp Thr Leu Val Ser Pro 

                405                 410                 415     





Phe Ile Asp Asp Asn Thr Arg Arg Lys Phe Leu Ile Tyr Ala Gly Asn 

            420                 425                 430         





Asp Tyr Gln Gly Pro Gly Gly Leu Leu Asp Tyr Ile Asp Lys Glu Ile 

        435                 440                 445             





Ile Pro Asp Phe Leu Ser Gly Glu Cys Met Cys Glu Val Pro Glu Gly 

    450                 455                 460                 





Gly Leu Val Pro Lys Ser Leu Tyr Arg Thr Ala Glu Glu Leu Glu Asn 

465                 470                 475                 480 





Glu Asp Leu Lys Leu Trp Thr Glu Thr Ile Tyr Gln Ser Ala Ser Val 

                485                 490                 495     





Phe Lys Gly Ala Pro His Glu Ile Leu Ile Gln Ile Val Asp Ala Ser 

            500                 505                 510         





Ser Val Ile Thr Trp Asp Phe Asp Val Cys Lys Gly Asp Ile Val Phe 

        515                 520                 525             





Asn Ile Tyr His Ser Lys Arg Ser Pro Gln Pro Pro Lys Lys Asp Ser 

    530                 535                 540                 





Leu Gly Ala His Ser Ile Thr Ser Pro Gly Gly Asn Asn Val Gln Leu 

545                 550                 555                 560 





Ile Asp Lys Val Trp Gln Leu Gly Arg Asp Tyr Ser Met Val Glu Ser 

                565                 570                 575     





Pro Leu Ile Cys Lys Glu Gly Glu Ser Val Gln Gly Ser His Val Thr 

            580                 585                 590         





Arg Trp Pro Gly Phe Tyr Ile Leu Gln Trp Lys Phe His Ser Met Pro 

        595                 600                 605             





Ala Cys Ala Ala Ser Ser Leu Pro Arg Val Asp Asp Val Leu Ala Ser 

    610                 615                 620                 





Leu Gln Val Ser Ser His Lys Cys Lys Val Met Tyr Tyr Thr Glu Val 

625                 630                 635                 640 





Ile Gly Ser Glu Asp Phe Arg Gly Ser Met Thr Ser Leu Glu Ser Ser 

                645                 650                 655     





His Ser Gly Phe Ser Gln Leu Ser Ala Ala Thr Thr Ser Ser Ser Gln 

            660                 665                 670         





Ser His Ser Ser Ser Met Ile Ser Arg 

        675                 680     





<210>  292

<211>  5493

<212>  DNA

<213>  Homo sapiens



<400>  292

gtcacccgta acaaccacaa gtgccgtcgc cgcgcccctt ccccctcccg cctccccggc       60



cccctccccg gaaccggcgg tcgagctacg gtcgcggagc agtggaaccg agactgcccc      120



gcggagccgc cgctagactt cgggctcctt gaggatattc agttttgtat gtttgaatat      180



cctctcacca tgttcagcat aaagtaccat tcttaatgat tatcctcaac aagacaggtg      240



tgagagggtt gctgttgtat tgcaatcatg gtgcagaaat accagtcccc agtgagggtg      300



tacaaatacc cctttgaatt aattatggct gcctatgaaa ggaggttccc tacatgtcct      360



ttgattccga tgttcgtggg cagtgacact gtgaatgaat tcaagagcga agatggggct      420



attcatgtca ttgaaaggcg ctgcaagctg gatgtagatg cacccagact gctgaagaag      480



attgcaggag ttgattatgt ttattttgtc cagaaaaact cactgaattc tcgggaacgt      540



actttgcaca ttgaggctta taatgaaacg ttttccaatc gggtcatcat taatgagcat      600



tgctgctaca ccgttcaccc tgaaaatgaa gattggacct gttttgaaca gtctgcaagt      660



ttagatatta aatctttctt tggttttgaa agtacagtgg aaaaaattgc aatgaaacaa      720



tataccagca acattaaaaa aggaaaggaa atcatcgaat actaccttcg ccaattagaa      780



gaagaaggca taacctttgt gccccgttgg agtccgcctt ccatcacgcc ctcttcagag      840



acatcttcat catcctccaa gaaacaagca gcgtccatgg ccgtcgtcat cccagaagct      900



gccctcaagg aggggctgag tggtgatgcc ctcagcagcc ccagcgcacc tgagcccgtg      960



gtgggcaccc ctgacgacaa actagatgcc gactacatca agagatacct gggcgatttg     1020



actccgctgc aggagagctg cctcattaga cttcgccagt ggctccagga gacccacaag     1080



ggcaaaattc caaaagatga gcatattctt cggttcctcc gtgcacggga ttttaatatt     1140



gacaaagcca gagagatcat gtgtcagtct ttgacgtgga gaaagcagca tcaggtagac     1200



tacattcttg aaacctggac ccctcctcag gtccttcagg attactacgc gggaggctgg     1260



catcatcacg acaaagatgg gcggcccctc tacgtgctca ggctggggca gatggacacc     1320



aaaggcttgg tgagagcgct cggggaggaa gccctgctga gatacgttct ctccataaat     1380



gaagaagggc taaggcgatg cgaagagaat acaaaagtct ttggtcggcc tatcagctca     1440



tggacctgcc tggtggactt ggaagggctg aacatgcgcc acttgtggag acctggtgtg     1500



aaagcgctgc tgcggatcat cgaggtggtg gaggccaact accctgagac actgggccgc     1560



cttctcatcc tgcgggcgcc cagggtattt cctgtgctct ggacgctggt tagtccgttc     1620



attgatgaca acaccagaag gaagttcctc atttatgcag gaaatgacta ccagggtcct     1680



ggaggcctgc tggattacat cgacaaagag attattccag atttcctgag tggggagtgc     1740



atgtgcgaag tgccagaggg tggactggtc cccaaatctc tgtaccggac tgcagaggag     1800



ctggagaacg aagacctgaa gctctggact gagaccatct accagtctgc aagcgtcttc     1860



aaaggagccc cacatgagat tctcattcag attgtggatg cctcgtcagt catcacttgg     1920



gatttcgacg tgtgcaaagg ggacattgtg tttaacatct atcactccaa gaggtcgcca     1980



caaccaccca aaaaggactc cctgggagcc cacagcatca cctctccggg tgggaacaat     2040



gtgcagctca tagacaaagt ctggcagctg ggccgcgact acagcatggt ggagtcgcct     2100



ctgatctgca aagaaggaga aagcgtgcag ggttcccatg tgaccaggtg gccgggcttc     2160



tacatcctgc agtggaaatt ccacagcatg cctgcgtgcg ccgccagcag ccttccccgg     2220



gtggacgacg tgcttgcgtc cctgcaggtc tcttcgcaca agtgtaaagt gatgtactac     2280



accgaggtga tcggctcgga ggatttcaga ggttccatga cgagcctgga gtccagccac     2340



agcggcttct cccagctgag tgccgccacc acctcctcca gccagtccca ctccagctcc     2400



atgatctcca ggtagtgccg cgctgcctgc acctagtgtg cagaggggac ggccgcccct     2460



cctcggacag ccagctgcac ccgcccaccc agcggcgaca ttgtacagac tcctctcacc     2520



tctagatagc aaatagctct cagatggtaa acgtagtcgt ttgatcccaa aactaccttg     2580



gcaggtagtt ttaactctga tcctaactta actcaatagc catagatttt gtatacgttg     2640



tgcacaaaat ccaaccagag cgcaagggct ctcttgaaag aaaagtagtt tctgtaccaa     2700



ttaaaggatt gacgtggtct cagatattga tgcaaaaaat ttttccaacg aactccgcat     2760



tgtccattag tgaatgaatt cctgtgacat cctccagaga tggcccctcc tcacctggga     2820



cggaagctgc cagctcgctt cccccaagct gcctcatggc ccgcacgccg cctcacggcc     2880



cccatgcttc ccgccagtca agatggtctg tggacttagg gccagccctt gaggtcctta     2940



tcctctgagg attcagaggt tgcctgcgga gtaccttgtc ccagggccag acacacccac     3000



accacccact gtcctgcagt ggggccgggg gctcaggagg ggctctcagg gactcctggt     3060



gactccagga aaatgctgcc atcgttaaac attactttct ctttcctcct tttcaaatct     3120



ttttgatact ttttagagca ggatttttct gtatgtgaac ttgggtgggg gggttcttcc     3180



cgtttccttc cgtgcgtcgc ccctctcacc tgcagtcagc tcccagccca gtgtaggcca     3240



tctcctctgt gccctctggt ggctcattgt cctcagagcc cagacagttc cagccactag     3300



gaggccgtct tggaaccagc aagtcgcatt tgccacttga cactgtccat ggggttttat     3360



tagtagctaa gcagcagctc tcgcatccac ttcagggtgg cgtgtggcat gtaggagtcc     3420



tgcttctttg tacatgggaa ttgtggactc atgcgtgtgt gtgtgtgcat gtgctgtgtg     3480



tgtgcatgtg tgcatgacgg tgggggtgct ggggggacgg ggtgagtgga aacttagttt     3540



gagtaatgaa ggaatcttca cagaagcaaa tcagaatatg ggatttgttt gccttttaca     3600



ttttgtttaa ttcctgattt taaagcctgc tctatctggt acaggccctt attttttcag     3660



ctttttatgg gaaaagcagg ttatttgaga atctgtccag aagttgcata ggggatggcc     3720



tccacgataa ggacatgcaa cacgtgtttc tgtgtgcagc agaggccgtg tttttcatgc     3780



caaaccccac gcggctgtca actgtgtgcg tggtaggcat ggagatcctg gttgtgccgt     3840



ctcagctccg ctctgaaggc actgtgtggg tgctgcgtga ctggagagct gtgtggaggc     3900



catgtgtgcc ccgtgcaggg atcaggaggg cgggggaggg accgagcagc cctcttgccc     3960



ggtcgggtca gccctagtgg ctgcctgcac actgtagacg tcccagggcc tgtgctgtga     4020



tcacctgcct ttggaccaca tttgtgtttg ctcttagaga tcgagctcct cagtggtacc     4080



tgaagccttt gcttccggaa agcgcggtag ggttcgtagg tagggctagt aggtagggtt     4140



agtaggtagg gctagtaggt agggctagta ggtagggttc gtaggtaggg ttcgtaggta     4200



gggctggtag gtagggttag taggtagggc tagtaggtag ggttagtagg tagggttcgt     4260



aggtagggtt cgtaggtagg gttcgtaggt agggctagta ggtagggtta gtaggtaggg     4320



ttcgtaggta gggttcgtag gtagggttag gtagggttcg taggtagggt tagtaggtag     4380



ggctagtagg tagggttcgt aggtagggtt cgtaggtagg gctagtaggt agggttagta     4440



ggtagggcta gtaggtaggg ctagtaggta gggttagtag gtagggctag taggtagggt     4500



tcgtaggtag ggttagtagg tagggctagt aggtagggtt cgtaggtagg gttcgtaggt     4560



agggctagta ggtagggtta gtaggtaggg ctagtaggta gggctagtag gtagggttcg     4620



taggtagggt tcgtaggtag ggttcgtagg tagggttcgt aggtagggtt agtaggtagg     4680



gttcgtaggt agggctagta ggtagggcta gtaggtaggg ctagtaggta gggttagtag     4740



gtagggctag taggtagggc tagtaggtag ggctagtagg tagggctagt aggtagggtt     4800



cgtaggtagg gttcgtaggt agggttcgta ggtagggtta gtagcgcgtc tgtgctgctt     4860



ccacctggtg cttcctgttc ccaaatcaca agggcctgaa ggtggtccct gctttctctt     4920



tctctttctc tgtgtctcag atggcgattt tgctgacagc tgccaagaaa atgcttcact     4980



caacagtcct catgtgccca gagatgttta tagaactgtt tgaattgcag ccatcccctg     5040



ccccctccca ggctgaagat ctgttctttt taagttgatt cgggagtggc attcttttat     5100



acccaaagac tgtagtgcat cttgaagagc tcaaagcaca tgaccgcaca aatgcttaca     5160



gggtttcctc ccgagtaatc caatctcact ccccttgtaa gggaattctg gggcagctat     5220



ggtttgagta tgcagtttgc atcgtgtttc tacctttagt accttgccac tcttttaaaa     5280



cgctgctgtc atttcccatt tcttagtact aatgattctt tgattctccc tctattatgt     5340



cttaattcac tttccttcct aaatttgtta tttgcatatc aaattctgta aatgttttgt     5400



aaacatatta cctcacttgg taatacaata ctgatagtct ttaaaagatt tttttattgt     5460



tatcaataat aaatgtgaac tatttaaaga aaa                                  5493





<210>  293

<211>  715

<212>  PRT

<213>  Homo sapiens



<400>  293



Met Val Gln Lys Tyr Gln Ser Pro Val Arg Val Tyr Lys Tyr Pro Phe 

1               5                   10                  15      





Glu Leu Ile Met Ala Ala Tyr Glu Arg Arg Phe Pro Thr Cys Pro Leu 

            20                  25                  30          





Ile Pro Met Phe Val Gly Ser Asp Thr Val Asn Glu Phe Lys Ser Glu 

        35                  40                  45              





Asp Gly Ala Ile His Val Ile Glu Arg Arg Cys Lys Leu Asp Val Asp 

    50                  55                  60                  





Ala Pro Arg Leu Leu Lys Lys Ile Ala Gly Val Asp Tyr Val Tyr Phe 

65                  70                  75                  80  





Val Gln Lys Asn Ser Leu Asn Ser Arg Glu Arg Thr Leu His Ile Glu 

                85                  90                  95      





Ala Tyr Asn Glu Thr Phe Ser Asn Arg Val Ile Ile Asn Glu His Cys 

            100                 105                 110         





Cys Tyr Thr Val His Pro Glu Asn Glu Asp Trp Thr Cys Phe Glu Gln 

        115                 120                 125             





Ser Ala Ser Leu Asp Ile Lys Ser Phe Phe Gly Phe Glu Ser Thr Val 

    130                 135                 140                 





Glu Lys Ile Ala Met Lys Gln Tyr Thr Ser Asn Ile Lys Lys Gly Lys 

145                 150                 155                 160 





Glu Ile Ile Glu Tyr Tyr Leu Arg Gln Leu Glu Glu Glu Gly Ile Thr 

                165                 170                 175     





Phe Val Pro Arg Trp Ser Pro Pro Ser Ile Thr Pro Ser Ser Glu Thr 

            180                 185                 190         





Ser Ser Ser Ser Ser Lys Lys Gln Ala Ala Ser Met Ala Val Val Ile 

        195                 200                 205             





Pro Glu Ala Ala Leu Lys Glu Gly Leu Ser Gly Asp Ala Leu Ser Ser 

    210                 215                 220                 





Pro Ser Ala Pro Glu Pro Val Val Gly Thr Pro Asp Asp Lys Leu Asp 

225                 230                 235                 240 





Ala Asp Tyr Ile Lys Arg Tyr Leu Gly Asp Leu Thr Pro Leu Gln Glu 

                245                 250                 255     





Ser Cys Leu Ile Arg Leu Arg Gln Trp Leu Gln Glu Thr His Lys Gly 

            260                 265                 270         





Lys Ile Pro Lys Asp Glu His Ile Leu Arg Phe Leu Arg Ala Arg Asp 

        275                 280                 285             





Phe Asn Ile Asp Lys Ala Arg Glu Ile Met Cys Gln Ser Leu Thr Trp 

    290                 295                 300                 





Arg Lys Gln His Gln Val Asp Tyr Ile Leu Glu Thr Trp Thr Pro Pro 

305                 310                 315                 320 





Gln Val Leu Gln Asp Tyr Tyr Ala Gly Gly Trp His His His Asp Lys 

                325                 330                 335     





Asp Gly Arg Pro Leu Tyr Val Leu Arg Leu Gly Gln Met Asp Thr Lys 

            340                 345                 350         





Gly Leu Val Arg Ala Leu Gly Glu Glu Ala Leu Leu Arg Tyr Val Leu 

        355                 360                 365             





Ser Ile Asn Glu Glu Gly Leu Arg Arg Cys Glu Glu Asn Thr Lys Val 

    370                 375                 380                 





Phe Gly Arg Pro Ile Ser Ser Trp Thr Cys Leu Val Asp Leu Glu Gly 

385                 390                 395                 400 





Leu Asn Met Arg His Leu Trp Arg Pro Gly Val Lys Ala Leu Leu Arg 

                405                 410                 415     





Ile Ile Glu Val Val Glu Ala Asn Tyr Pro Glu Thr Leu Gly Arg Leu 

            420                 425                 430         





Leu Ile Leu Arg Ala Pro Arg Val Phe Pro Val Leu Trp Thr Leu Val 

        435                 440                 445             





Ser Pro Phe Ile Asp Asp Asn Thr Arg Arg Lys Phe Leu Ile Tyr Ala 

    450                 455                 460                 





Gly Asn Asp Tyr Gln Gly Pro Gly Gly Leu Leu Asp Tyr Ile Asp Lys 

465                 470                 475                 480 





Glu Ile Ile Pro Asp Phe Leu Ser Gly Glu Cys Met Cys Glu Val Pro 

                485                 490                 495     





Glu Gly Gly Leu Val Pro Lys Ser Leu Tyr Arg Thr Ala Glu Glu Leu 

            500                 505                 510         





Glu Asn Glu Asp Leu Lys Leu Trp Thr Glu Thr Ile Tyr Gln Ser Ala 

        515                 520                 525             





Ser Val Phe Lys Gly Ala Pro His Glu Ile Leu Ile Gln Ile Val Asp 

    530                 535                 540                 





Ala Ser Ser Val Ile Thr Trp Asp Phe Asp Val Cys Lys Gly Asp Ile 

545                 550                 555                 560 





Val Phe Asn Ile Tyr His Ser Lys Arg Ser Pro Gln Pro Pro Lys Lys 

                565                 570                 575     





Asp Ser Leu Gly Ala His Ser Ile Thr Ser Pro Gly Gly Asn Asn Val 

            580                 585                 590         





Gln Leu Ile Asp Lys Val Trp Gln Leu Gly Arg Asp Tyr Ser Met Val 

        595                 600                 605             





Glu Ser Pro Leu Ile Cys Lys Glu Gly Glu Ser Val Gln Gly Ser His 

    610                 615                 620                 





Val Thr Arg Trp Pro Gly Phe Tyr Ile Leu Gln Trp Lys Phe His Ser 

625                 630                 635                 640 





Met Pro Ala Cys Ala Ala Ser Ser Leu Pro Arg Val Asp Asp Val Leu 

                645                 650                 655     





Ala Ser Leu Gln Val Ser Ser His Lys Cys Lys Val Met Tyr Tyr Thr 

            660                 665                 670         





Glu Val Ile Gly Ser Glu Asp Phe Arg Gly Ser Met Thr Ser Leu Glu 

        675                 680                 685             





Ser Ser His Ser Gly Phe Ser Gln Leu Ser Ala Ala Thr Thr Ser Ser 

    690                 695                 700                 





Ser Gln Ser His Ser Ser Ser Met Ile Ser Arg 

705                 710                 715 





<210>  294

<211>  2889

<212>  DNA

<213>  Homo sapiens



<400>  294

gcggcggggc tccggctgcg ctcgtggccg ggccgggcgg ggaggccggt cccgcgggcg       60



ggggcagggg cggctccgcg gcttctcccg ccgccgccgc caaggggagt ttccaggaag      120



tggccatatt ggatccattc agccgcagcc gcccgggcgg agcgcgtccc gcagccggct      180



ggtccctgtc gctgcccctg cgctcgtccc agcccacccg cccggtgcgg agctcgccat      240



ggcggccacc gacctggagc gcttctcgaa tgcagagcca gagccccgga gcctctccct      300



gggcggccat gtgggtttcg acagcctccc cgaccagctg gtcagcaagt cggtcactca      360



gggcttcagc ttcaacatcc tctgtgtggg ggagaccggc attggcaaat ccacactgat      420



gaacacactc ttcaacacga ccttcgagac tgaggaagcc agtcaccatg aggcatgcgt      480



gcgcctgcgg ccccagacct atgacctcca ggagagcaac gtgcagctca agctgaccat      540



tgtggatgcc gtgggctttg gggatcagat caataaggat gagagttaca ggcccatagt      600



tgactacatc gatgcgcagt ttgaaaatta tctgcaggag gagctgaaga tccgccgctc      660



gctcttcgac taccatgaca caaggatcca cgtttgcctc tacttcatca cgcccacagg      720



gcactccctg aagtctctag atctagtgac catgaagaaa ctagacagca aggtgaacat      780



tattcccatc atcgccaagg ctgacaccat ctccaagagc gagctccaca agttcaagat      840



caagatcatg ggcgagttgg tcagcaacgg ggtccagatc taccagttcc ccacggatga      900



tgaggctgtt gcagagatta acgcagtcat gaatgcacat ctgccctttg ccgtggtggg      960



cagcaccgag gaggtgaagg tggggaacaa gctggtccga gcacggcagt acccctgggg     1020



agtggtgcag gtggagaatg agaatcactg cgacttcgtg aagctgcggg agatgttgat     1080



ccgggtgaac atggaagacc tccgcgagca gacccacagc cggcactacg agctctaccg     1140



gcgctgcaag ttggaggaga tgggctttca ggacagcgat ggtgacagcc agcccttcag     1200



cctacaagag acatacgagg ccaagaggaa ggagttccta agtgagctgc agaggaagga     1260



ggaagagatg aggcagatgt ttgtcaacaa agtgaaggag acagagctgg agctgaagga     1320



gaaggaaagg gagctccatg agaagtttga gcacctgaag cgggtccacc aggaggagaa     1380



gcgcaaggtg gaggaaaagc gccgggaact ggaggaggag accaacgcct tcaatcgccg     1440



gaaggctgcg gtggaggccc tgcagtcgca ggccttgcac gccacctcgc agcagcccct     1500



gaggaaggac aaggacaaga agaacagatc agatatagga gcacaccagc cgggcatgag     1560



cctctccagc tctaaggtga tgatgaccaa ggccagtgtg gagcccttga actgcagcag     1620



ctggtggccc gccatacagt gctgcagctg cctggtcagg gatgcgacgt ggagggaagg     1680



attcctctga ggcagcagct ccaacacatg gggccagctc aggaccacca gggcatggaa     1740



ctggagacca tggtttttaa tgttagaaca gaaaacgcca tacttttcct atatcaatga     1800



tcaaaagtgc aaacaattta aatttccatc agggaacatc aaatgttgcc caaccctttt     1860



cattcctatc catggctccg taaggggctt gaggcttaat gcccatcctg tggccaagct     1920



gagcttccac tccgggacca aaaaaaaaaa aaagtctgct ttgtgacatc atcgttatga     1980



gcggaaagta cctagatgac aatgtttcca ttctgaaaaa tagaaacata ctattcaaga     2040



ccaaggtagc agaaaagtta cttgtatctg cttatcataa gacgaaactc tgcaacttgg     2100



caacggtggc cagttttcgt aatgaaacag tctttagtaa tttaatcttc atgcttcata     2160



acaaaccaaa accccatgag atttccacat tgcataattt tgccttacta acagaatcat     2220



atccttaagg atgaccatca ttcccccaac taaaacaaat acaaactaat gtatgatatt     2280



tttttaagtg ccagatcaat atggtctaaa gcttcaataa ggattgtgtg taggtgaata     2340



aagacagcta agtgaatgtg tgtaaagtgt agcaaaagca gacagatatt tatgtacagt     2400



attcatagaa tggaaagtta aatatttttg cagtgtgtat ttaaaagaga aactcaccat     2460



aatagtgccg tctaaaaatc tttgtaaagt taatttaatg tcctttagaa gtgggagtct     2520



ggtggaactg tgttggattt aagatacctt ttcactcttc cgtatgtcat gagccttgtg     2580



cgtcacctca ctgtggtgca tgtgcaaggg cgtgtgcacg cctgtgcttt gccatcccat     2640



gttgtaaaca gctgttccaa aggcacaaac gagtttaggg tagactctgt aaacacctcc     2700



ttactcacta tagtcaagaa gtccagcggc gtcccaatat agaggtccca gtgcagtctg     2760



tccagaatag ccagctccat cctcagcagc tcattcgggg aatagtcaga gccatagtgc     2820



tttgtgaagt cttttacttg tggaataaac tgtaaaaaga aaataaagag gccaaagccc     2880



tacatcatg                                                             2889





<210>  295

<211>  483

<212>  PRT

<213>  Homo sapiens



<400>  295



Met Ala Ala Thr Asp Leu Glu Arg Phe Ser Asn Ala Glu Pro Glu Pro 

1               5                   10                  15      





Arg Ser Leu Ser Leu Gly Gly His Val Gly Phe Asp Ser Leu Pro Asp 

            20                  25                  30          





Gln Leu Val Ser Lys Ser Val Thr Gln Gly Phe Ser Phe Asn Ile Leu 

        35                  40                  45              





Cys Val Gly Glu Thr Gly Ile Gly Lys Ser Thr Leu Met Asn Thr Leu 

    50                  55                  60                  





Phe Asn Thr Thr Phe Glu Thr Glu Glu Ala Ser His His Glu Ala Cys 

65                  70                  75                  80  





Val Arg Leu Arg Pro Gln Thr Tyr Asp Leu Gln Glu Ser Asn Val Gln 

                85                  90                  95      





Leu Lys Leu Thr Ile Val Asp Ala Val Gly Phe Gly Asp Gln Ile Asn 

            100                 105                 110         





Lys Asp Glu Ser Tyr Arg Pro Ile Val Asp Tyr Ile Asp Ala Gln Phe 

        115                 120                 125             





Glu Asn Tyr Leu Gln Glu Glu Leu Lys Ile Arg Arg Ser Leu Phe Asp 

    130                 135                 140                 





Tyr His Asp Thr Arg Ile His Val Cys Leu Tyr Phe Ile Thr Pro Thr 

145                 150                 155                 160 





Gly His Ser Leu Lys Ser Leu Asp Leu Val Thr Met Lys Lys Leu Asp 

                165                 170                 175     





Ser Lys Val Asn Ile Ile Pro Ile Ile Ala Lys Ala Asp Thr Ile Ser 

            180                 185                 190         





Lys Ser Glu Leu His Lys Phe Lys Ile Lys Ile Met Gly Glu Leu Val 

        195                 200                 205             





Ser Asn Gly Val Gln Ile Tyr Gln Phe Pro Thr Asp Asp Glu Ala Val 

    210                 215                 220                 





Ala Glu Ile Asn Ala Val Met Asn Ala His Leu Pro Phe Ala Val Val 

225                 230                 235                 240 





Gly Ser Thr Glu Glu Val Lys Val Gly Asn Lys Leu Val Arg Ala Arg 

                245                 250                 255     





Gln Tyr Pro Trp Gly Val Val Gln Val Glu Asn Glu Asn His Cys Asp 

            260                 265                 270         





Phe Val Lys Leu Arg Glu Met Leu Ile Arg Val Asn Met Glu Asp Leu 

        275                 280                 285             





Arg Glu Gln Thr His Ser Arg His Tyr Glu Leu Tyr Arg Arg Cys Lys 

    290                 295                 300                 





Leu Glu Glu Met Gly Phe Gln Asp Ser Asp Gly Asp Ser Gln Pro Phe 

305                 310                 315                 320 





Ser Leu Gln Glu Thr Tyr Glu Ala Lys Arg Lys Glu Phe Leu Ser Glu 

                325                 330                 335     





Leu Gln Arg Lys Glu Glu Glu Met Arg Gln Met Phe Val Asn Lys Val 

            340                 345                 350         





Lys Glu Thr Glu Leu Glu Leu Lys Glu Lys Glu Arg Glu Leu His Glu 

        355                 360                 365             





Lys Phe Glu His Leu Lys Arg Val His Gln Glu Glu Lys Arg Lys Val 

    370                 375                 380                 





Glu Glu Lys Arg Arg Glu Leu Glu Glu Glu Thr Asn Ala Phe Asn Arg 

385                 390                 395                 400 





Arg Lys Ala Ala Val Glu Ala Leu Gln Ser Gln Ala Leu His Ala Thr 

                405                 410                 415     





Ser Gln Gln Pro Leu Arg Lys Asp Lys Asp Lys Lys Asn Arg Ser Asp 

            420                 425                 430         





Ile Gly Ala His Gln Pro Gly Met Ser Leu Ser Ser Ser Lys Val Met 

        435                 440                 445             





Met Thr Lys Ala Ser Val Glu Pro Leu Asn Cys Ser Ser Trp Trp Pro 

    450                 455                 460                 





Ala Ile Gln Cys Cys Ser Cys Leu Val Arg Asp Ala Thr Trp Arg Glu 

465                 470                 475                 480 





Gly Phe Leu 

            





<210>  296

<211>  4076

<212>  DNA

<213>  Homo sapiens



<400>  296

gcggcggggc tccggctgcg ctcgtggccg ggccgggcgg ggaggccggt cccgcgggcg       60



ggggcagggg cggctccgcg gcttctcccg ccgccgccgc caaggggagt ttccaggaag      120



tggccatatt ggatccattc agccgcagcc gcccgggcgg agcgcgtccc gcagccggct      180



ggtccctgtc gctgcccctg cgctcgtccc agcccacccg cccggtgcgg agctcgccat      240



ggcggccacc gacctggagc gcttctcgaa tgcagagcca gagccccgga gcctctccct      300



gggcggccat gtgggtttcg acagcctccc cgaccagctg gtcagcaagt cggtcactca      360



gggcttcagc ttcaacatcc tctgtgtggg ggagaccggc attggcaaat ccacactgat      420



gaacacactc ttcaacacga ccttcgagac tgaggaagcc agtcaccatg aggcatgcgt      480



gcgcctgcgg ccccagacct atgacctcca ggagagcaac gtgcagctca agctgaccat      540



tgtggatgcc gtgggctttg gggatcagat caataaggat gagagttaca ggcccatagt      600



tgactacatc gatgcgcagt ttgaaaatta tctgcaggag gagctgaaga tccgccgctc      660



gctcttcgac taccatgaca caaggatcca cgtttgcctc tacttcatca cgcccacagg      720



gcactccctg aagtctctag atctagtgac catgaagaaa ctagacagca aggtgaacat      780



tattcccatc atcgccaagg ctgacaccat ctccaagagc gagctccaca agttcaagat      840



caagatcatg ggcgagttgg tcagcaacgg ggtccagatc taccagttcc ccacggatga      900



tgaggctgtt gcagagatta acgcagtcat gaatgcacat ctgccctttg ccgtggtggg      960



cagcaccgag gaggtgaagg tggggaacaa gctggtccga gcacggcagt acccctgggg     1020



agtggtgcag gtggagaatg agaatcactg cgacttcgtg aagctgcggg agatgttgat     1080



ccgggtgaac atggaagacc tccgcgagca gacccacagc cggcactacg agctctaccg     1140



gcgctgcaag ttggaggaga tgggctttca ggacagcgat ggtgacagcc agcccttcag     1200



cctacaagag acatacgagg ccaagaggaa ggagttccta agtgagctgc agaggaagga     1260



ggaagagatg aggcagatgt ttgtcaacaa agtgaaggag acagagctgg agctgaagga     1320



gaaggaaagg gagctccatg agaagtttga gcacctgaag cgggtccacc aggaggagaa     1380



gcgcaaggtg gaggaaaagc gccgggaact ggaggaggag accaacgcct tcaatcgccg     1440



gaaggctgcg gtggaggccc tgcagtcgca ggccttgcac gccacctcgc agcagcccct     1500



gaggaaggac aaggacaaga agaaagccag tggctggtct tccatttaca gtgtcactat     1560



tccctgacgg agctgttatg tgccgctcta gcgaaggccc cagccgggat gctaggccta     1620



attgttcagc gtggagatgg caactcacgt ggtgccctag gtgcagctgc gtggtctggt     1680



atacatgctg caaaattcac ccagttcccc tcattttaat ttttctaacc tacagcttaa     1740



ttttaataac tttaaaacac ttctaaatat ttattttggc accagcgtca agacaaataa     1800



tatcctctcc cattattttc ataagtaaca cagattccct gatttttaaa aactaaaaat     1860



acagctaaac ctttcttatg tataaagtat gcctatcata tacagggaga ggtgggtaat     1920



aaacttcctg taatgacagt gtttggcatt tctttatgga tggaattgga acatgaacaa     1980



gaccatgtcc agcgttttta ctgtgaatgt aaatggaaca gcagcccaaa gctgttgtct     2040



gtgccccaga ggtgctacct gtagacaggg accaactcca tgtgtgtgtg ttaagtgttt     2100



gactccaatt aagactccca agcaaatcct gcatattcca aatgtaaaga gtactcagtg     2160



ggaaaaaggt tgttacctca aagtcattgc ttctttcctg gctgggtcac agggtgaaga     2220



gatgaaggtg tctgatgtat atagacaatt agggaaaaat gagcggcaaa ggagctttcc     2280



ccttcagctg cactctaaag gggaacattt taaggaagta ctagcagctt tgactcttct     2340



atgctcctgt tggtttacaa gccaccaaga atgtcagtgt tgagaatacg gcctggtaaa     2400



atgggagatg taaaatgact aaatgaaagg aagggtagtt ttaatgttga agcaccgtgc     2460



tgggcactgg agctacccag aggaatgcac aacgctcccc tcaaggagct cacagtctag     2520



cctactccct ggctggaagc ctcaggaaga cgtgctaatt tattgtggaa ttggtagttt     2580



gcttttcatg cccctgtctt ccttctcatg accatttccc cctttctgtc tggcttgcat     2640



tattgatttc caggaccaag tcctggcttc ctcctgcctt cctgagatga tgttctgctc     2700



agggagaagt ggaggggtga gctgtgtgtg tccaccgagg cacggccagg aagaggcagc     2760



ctttacctgt gaggggctcc atgctccagc agcagagcag gttctagtga caattcaact     2820



ttttatgcta tgaccagggg tggatctaaa ttttatgggg ctgaaagctt gaattattta     2880



gaaagacttc tttaagaaaa acaatgttaa tataaaatta ggtacagggt cttggaaggg     2940



gccctgaaga ttaagcttcc ttagcgtcac aataagtccg tatctggttg caattgaaaa     3000



ctgatgcttc agtgagggta tctaaaaagg taaactggca tatccagggc aaatgtgggc     3060



tgccaatggc tcatctctag ggtaatttta tgtctgaaag tgtatgcagt tgggtcagag     3120



catgaccttt aagatagcct ctctcagcta acatatttat gaagatgagg cctggtgacc     3180



cagcaggttc attggataca taagaaatga gaattcctgg ttcatgggcc aacctaggac     3240



tctggagtat gcagacttgg ccattcgtcc attgtggcct gcgggtcgca ccccaggcat     3300



actgaaaggc catactcgtg gctggctgcc tgcgggccta agccttccca ggatcttcag     3360



gacacttgac agacttgtgt tttctggtct gagctgcctc cacaggtccc tccagcaagc     3420



ctcactgcac ctctcccctg ctgtttgtgt ttggaatttt gtcttcttta gctgagacca     3480



aattaaacct tggtgcataa agtgagctta aaacttgcca ctgtttagta agttagcccc     3540



catagaatgt gaccctgtct gcagagtctc atttacccct ctttttctca ttgtcatttg     3600



ttggctttat tagggctgtc ttacaggatc atgttggcat ttactatcat gtctttatca     3660



taaaccatgt ttgtttgagg tagaagaatc accatataat tcgttgccca aattgggact     3720



attgagagag aaaggggatg ctattaatta caccagatca aaaggcataa accagacctg     3780



tcccaggccg atgtggaaat atgttctttc tagttgtggg taccctgatc taggtggttt     3840



gtaattgtgc attactgact gcatatgttt gtgtatgtgt aaatgtgggc tccctgttaa     3900



gtggggctca tggatacgag gcctgaggaa gtgtggcttg ctagtctgtt acgttaacat     3960



gcttttctaa aattgcttca cgtgttaatt catttactcc tgcattcatt gactgttttt     4020



gttcttttcc attcactttg tacttatttt tttcattaaa ttttgcattt attttg         4076





<210>  297

<211>  442

<212>  PRT

<213>  Homo sapiens



<400>  297



Met Ala Ala Thr Asp Leu Glu Arg Phe Ser Asn Ala Glu Pro Glu Pro 

1               5                   10                  15      





Arg Ser Leu Ser Leu Gly Gly His Val Gly Phe Asp Ser Leu Pro Asp 

            20                  25                  30          





Gln Leu Val Ser Lys Ser Val Thr Gln Gly Phe Ser Phe Asn Ile Leu 

        35                  40                  45              





Cys Val Gly Glu Thr Gly Ile Gly Lys Ser Thr Leu Met Asn Thr Leu 

    50                  55                  60                  





Phe Asn Thr Thr Phe Glu Thr Glu Glu Ala Ser His His Glu Ala Cys 

65                  70                  75                  80  





Val Arg Leu Arg Pro Gln Thr Tyr Asp Leu Gln Glu Ser Asn Val Gln 

                85                  90                  95      





Leu Lys Leu Thr Ile Val Asp Ala Val Gly Phe Gly Asp Gln Ile Asn 

            100                 105                 110         





Lys Asp Glu Ser Tyr Arg Pro Ile Val Asp Tyr Ile Asp Ala Gln Phe 

        115                 120                 125             





Glu Asn Tyr Leu Gln Glu Glu Leu Lys Ile Arg Arg Ser Leu Phe Asp 

    130                 135                 140                 





Tyr His Asp Thr Arg Ile His Val Cys Leu Tyr Phe Ile Thr Pro Thr 

145                 150                 155                 160 





Gly His Ser Leu Lys Ser Leu Asp Leu Val Thr Met Lys Lys Leu Asp 

                165                 170                 175     





Ser Lys Val Asn Ile Ile Pro Ile Ile Ala Lys Ala Asp Thr Ile Ser 

            180                 185                 190         





Lys Ser Glu Leu His Lys Phe Lys Ile Lys Ile Met Gly Glu Leu Val 

        195                 200                 205             





Ser Asn Gly Val Gln Ile Tyr Gln Phe Pro Thr Asp Asp Glu Ala Val 

    210                 215                 220                 





Ala Glu Ile Asn Ala Val Met Asn Ala His Leu Pro Phe Ala Val Val 

225                 230                 235                 240 





Gly Ser Thr Glu Glu Val Lys Val Gly Asn Lys Leu Val Arg Ala Arg 

                245                 250                 255     





Gln Tyr Pro Trp Gly Val Val Gln Val Glu Asn Glu Asn His Cys Asp 

            260                 265                 270         





Phe Val Lys Leu Arg Glu Met Leu Ile Arg Val Asn Met Glu Asp Leu 

        275                 280                 285             





Arg Glu Gln Thr His Ser Arg His Tyr Glu Leu Tyr Arg Arg Cys Lys 

    290                 295                 300                 





Leu Glu Glu Met Gly Phe Gln Asp Ser Asp Gly Asp Ser Gln Pro Phe 

305                 310                 315                 320 





Ser Leu Gln Glu Thr Tyr Glu Ala Lys Arg Lys Glu Phe Leu Ser Glu 

                325                 330                 335     





Leu Gln Arg Lys Glu Glu Glu Met Arg Gln Met Phe Val Asn Lys Val 

            340                 345                 350         





Lys Glu Thr Glu Leu Glu Leu Lys Glu Lys Glu Arg Glu Leu His Glu 

        355                 360                 365             





Lys Phe Glu His Leu Lys Arg Val His Gln Glu Glu Lys Arg Lys Val 

    370                 375                 380                 





Glu Glu Lys Arg Arg Glu Leu Glu Glu Glu Thr Asn Ala Phe Asn Arg 

385                 390                 395                 400 





Arg Lys Ala Ala Val Glu Ala Leu Gln Ser Gln Ala Leu His Ala Thr 

                405                 410                 415     





Ser Gln Gln Pro Leu Arg Lys Asp Lys Asp Lys Lys Lys Ala Ser Gly 

            420                 425                 430         





Trp Ser Ser Ile Tyr Ser Val Thr Ile Pro 

        435                 440         





<210>  298

<211>  4270

<212>  DNA

<213>  Homo sapiens



<400>  298

tgctcgttgg ttgcacaagg agccgaaggc tggtcccttg cccgggaagg ccgcctggcc       60



ggacgcgcgg gtcccgccgg ggttcccgcc ttagctccgg ccggagcatc aggtggggcc      120



caagacaccc gcagactagg ctgccgcggc ctctcccgga tccgacgggt ctcccgcagc      180



ttgtccacac tctgaatgca gagccagagc cccggagcct ctccctgggc ggccatgtgg      240



gtttcgacag cctccccgac cagctggtca gcaagtcggt cactcagggc ttcagcttca      300



acatcctctg tgtgggggag accggcattg gcaaatccac actgatgaac acactcttca      360



acacgacctt cgagactgag gaagccagtc accatgaggc atgcgtgcgc ctgcggcccc      420



agacctatga cctccaggag agcaacgtgc agctcaagct gaccattgtg gatgccgtgg      480



gctttgggga tcagatcaat aaggatgaga gttacaggcc catagttgac tacatcgatg      540



cgcagtttga aaattatctg caggaggagc tgaagatccg ccgctcgctc ttcgactacc      600



atgacacaag gatccacgtt tgcctctact tcatcacgcc cacagggcac tccctgaagt      660



ctctagatct agtgaccatg aagaaactag acagcaaggt gaacattatt cccatcatcg      720



ccaaggctga caccatctcc aagagcgagc tccacaagtt caagatcaag atcatgggcg      780



agttggtcag caacggggtc cagatctacc agttccccac ggatgatgag gctgttgcag      840



agattaacgc agtcatgaat gcacatctgc cctttgccgt ggtgggcagc accgaggagg      900



tgaaggtggg gaacaagctg gtccgagcac ggcagtaccc ctggggagtg gtgcaggtgg      960



agaatgagaa tcactgcgac ttcgtgaagc tgcgggagat gttgatccgg gtgaacatgg     1020



aagacctccg cgagcagacc cacagccggc actacgagct ctaccggcgc tgcaagttgg     1080



aggagatggg ctttcaggac agcgatggtg acagccagcc cttcagccta caagagacat     1140



acgaggccaa gaggaaggag ttcctaagtg agctgcagag gaaggaggaa gagatgaggc     1200



agatgtttgt caacaaagtg aaggagacag agctggagct gaaggagaag gaaagggagc     1260



tccatgagaa gtttgagcac ctgaagcggg tccaccagga ggagaagcgc aaggtggagg     1320



aaaagcgccg ggaactggag gaggagacca acgccttcaa tcgccggaag gctgcggtgg     1380



aggccctgca gtcgcaggcc ttgcacgcca cctcgcagca gcccctgagg aaggacaagg     1440



acaagaagaa ttaacgcacg cacagactta catgtcaaga gtggacttta gactttcatg     1500



tgttaagttg cttgagttac accttgtgac ccttctccca taacatggtg tgaggacgga     1560



ctgggagccg gtacagactc cagtgtttac agccttgctt tcctcccacc gaccctggcc     1620



ccaggctgcc ccgggcctgg cgggccaccc ctctctatgc aaacacgtaa aagccatgaa     1680



tgctggaatc caaaactgac gaggtttatt tttttcagag ccagtggctg gtcttccatt     1740



tacagtgtca ctattccctg acggagctgt tatgtgccgc tctagcgaag gccccagccg     1800



ggatgctagg cctaattgtt cagcgtggag atggcaactc acgtggtgcc ctaggtgcag     1860



ctgcgtggtc tggtatacat gctgcaaaat tcacccagtt cccctcattt taatttttct     1920



aacctacagc ttaattttaa taactttaaa acacttctaa atatttattt tggcaccagc     1980



gtcaagacaa ataatatcct ctcccattat tttcataagt aacacagatt ccctgatttt     2040



taaaaactaa aaatacagct aaacctttct tatgtataaa gtatgcctat catatacagg     2100



gagaggtggg taataaactt cctgtaatga cagtgtttgg catttcttta tggatggaat     2160



tggaacatga acaagaccat gtccagcgtt tttactgtga atgtaaatgg aacagcagcc     2220



caaagctgtt gtctgtgccc cagaggtgct acctgtagac agggaccaac tccatgtgtg     2280



tgtgttaagt gtttgactcc aattaagact cccaagcaaa tcctgcatat tccaaatgta     2340



aagagtactc agtgggaaaa aggttgttac ctcaaagtca ttgcttcttt cctggctggg     2400



tcacagggtg aagagatgaa ggtgtctgat gtatatagac aattagggaa aaatgagcgg     2460



caaaggagct ttccccttca gctgcactct aaaggggaac attttaagga agtactagca     2520



gctttgactc ttctatgctc ctgttggttt acaagccacc aagaatgtca gtgttgagaa     2580



tacggcctgg taaaatggga gatgtaaaat gactaaatga aaggaagggt agttttaatg     2640



ttgaagcacc gtgctgggca ctggagctac ccagaggaat gcacaacgct cccctcaagg     2700



agctcacagt ctagcctact ccctggctgg aagcctcagg aagacgtgct aatttattgt     2760



ggaattggta gtttgctttt catgcccctg tcttccttct catgaccatt tccccctttc     2820



tgtctggctt gcattattga tttccaggac caagtcctgg cttcctcctg ccttcctgag     2880



atgatgttct gctcagggag aagtggaggg gtgagctgtg tgtgtccacc gaggcacggc     2940



caggaagagg cagcctttac ctgtgagggg ctccatgctc cagcagcaga gcaggttcta     3000



gtgacaattc aactttttat gctatgacca ggggtggatc taaattttat ggggctgaaa     3060



gcttgaatta tttagaaaga cttctttaag aaaaacaatg ttaatataaa attaggtaca     3120



gggtcttgga aggggccctg aagattaagc ttccttagcg tcacaataag tccgtatctg     3180



gttgcaattg aaaactgatg cttcagtgag ggtatctaaa aaggtaaact ggcatatcca     3240



gggcaaatgt gggctgccaa tggctcatct ctagggtaat tttatgtctg aaagtgtatg     3300



cagttgggtc agagcatgac ctttaagata gcctctctca gctaacatat ttatgaagat     3360



gaggcctggt gacccagcag gttcattgga tacataagaa atgagaattc ctggttcatg     3420



ggccaaccta ggactctgga gtatgcagac ttggccattc gtccattgtg gcctgcgggt     3480



cgcaccccag gcatactgaa aggccatact cgtggctggc tgcctgcggg cctaagcctt     3540



cccaggatct tcaggacact tgacagactt gtgttttctg gtctgagctg cctccacagg     3600



tccctccagc aagcctcact gcacctctcc cctgctgttt gtgtttggaa ttttgtcttc     3660



tttagctgag accaaattaa accttggtgc ataaagtgag cttaaaactt gccactgttt     3720



agtaagttag cccccataga atgtgaccct gtctgcagag tctcatttac ccctcttttt     3780



ctcattgtca tttgttggct ttattagggc tgtcttacag gatcatgttg gcatttacta     3840



tcatgtcttt atcataaacc atgtttgttt gaggtagaag aatcaccata taattcgttg     3900



cccaaattgg gactattgag agagaaaggg gatgctatta attacaccag atcaaaaggc     3960



ataaaccaga cctgtcccag gccgatgtgg aaatatgttc tttctagttg tgggtaccct     4020



gatctaggtg gtttgtaatt gtgcattact gactgcatat gtttgtgtat gtgtaaatgt     4080



gggctccctg ttaagtgggg ctcatggata cgaggcctga ggaagtgtgg cttgctagtc     4140



tgttacgtta acatgctttt ctaaaattgc ttcacgtgtt aattcattta ctcctgcatt     4200



cattgactgt ttttgttctt ttccattcac tttgtactta tttttttcat taaattttgc     4260



atttattttg                                                            4270





<210>  299

<211>  369

<212>  PRT

<213>  Homo sapiens



<400>  299



Met Asn Thr Leu Phe Asn Thr Thr Phe Glu Thr Glu Glu Ala Ser His 

1               5                   10                  15      





His Glu Ala Cys Val Arg Leu Arg Pro Gln Thr Tyr Asp Leu Gln Glu 

            20                  25                  30          





Ser Asn Val Gln Leu Lys Leu Thr Ile Val Asp Ala Val Gly Phe Gly 

        35                  40                  45              





Asp Gln Ile Asn Lys Asp Glu Ser Tyr Arg Pro Ile Val Asp Tyr Ile 

    50                  55                  60                  





Asp Ala Gln Phe Glu Asn Tyr Leu Gln Glu Glu Leu Lys Ile Arg Arg 

65                  70                  75                  80  





Ser Leu Phe Asp Tyr His Asp Thr Arg Ile His Val Cys Leu Tyr Phe 

                85                  90                  95      





Ile Thr Pro Thr Gly His Ser Leu Lys Ser Leu Asp Leu Val Thr Met 

            100                 105                 110         





Lys Lys Leu Asp Ser Lys Val Asn Ile Ile Pro Ile Ile Ala Lys Ala 

        115                 120                 125             





Asp Thr Ile Ser Lys Ser Glu Leu His Lys Phe Lys Ile Lys Ile Met 

    130                 135                 140                 





Gly Glu Leu Val Ser Asn Gly Val Gln Ile Tyr Gln Phe Pro Thr Asp 

145                 150                 155                 160 





Asp Glu Ala Val Ala Glu Ile Asn Ala Val Met Asn Ala His Leu Pro 

                165                 170                 175     





Phe Ala Val Val Gly Ser Thr Glu Glu Val Lys Val Gly Asn Lys Leu 

            180                 185                 190         





Val Arg Ala Arg Gln Tyr Pro Trp Gly Val Val Gln Val Glu Asn Glu 

        195                 200                 205             





Asn His Cys Asp Phe Val Lys Leu Arg Glu Met Leu Ile Arg Val Asn 

    210                 215                 220                 





Met Glu Asp Leu Arg Glu Gln Thr His Ser Arg His Tyr Glu Leu Tyr 

225                 230                 235                 240 





Arg Arg Cys Lys Leu Glu Glu Met Gly Phe Gln Asp Ser Asp Gly Asp 

                245                 250                 255     





Ser Gln Pro Phe Ser Leu Gln Glu Thr Tyr Glu Ala Lys Arg Lys Glu 

            260                 265                 270         





Phe Leu Ser Glu Leu Gln Arg Lys Glu Glu Glu Met Arg Gln Met Phe 

        275                 280                 285             





Val Asn Lys Val Lys Glu Thr Glu Leu Glu Leu Lys Glu Lys Glu Arg 

    290                 295                 300                 





Glu Leu His Glu Lys Phe Glu His Leu Lys Arg Val His Gln Glu Glu 

305                 310                 315                 320 





Lys Arg Lys Val Glu Glu Lys Arg Arg Glu Leu Glu Glu Glu Thr Asn 

                325                 330                 335     





Ala Phe Asn Arg Arg Lys Ala Ala Val Glu Ala Leu Gln Ser Gln Ala 

            340                 345                 350         





Leu His Ala Thr Ser Gln Gln Pro Leu Arg Lys Asp Lys Asp Lys Lys 

        355                 360                 365             





Asn 

    





<210>  300

<211>  4344

<212>  DNA

<213>  Homo sapiens



<400>  300

gcggcggggc tccggctgcg ctcgtggccg ggccgggcgg ggaggccggt cccgcgggcg       60



ggggcagggg cggctccgcg gcttctcccg ccgccgccgc caaggggagt ttccaggaag      120



tggccatatt ggatccattc agccgcagcc gcccgggcgg agcgcgtccc gcagccggct      180



ggtccctgtc gctgcccctg cgctcgtccc agcccacccg cccggtgcgg agctcgccat      240



ggcggccacc gacctggagc gcttctcgaa tgcagagcca gagccccgga gcctctccct      300



gggcggccat gtgggtttcg acagcctccc cgaccagctg gtcagcaagt cggtcactca      360



gggcttcagc ttcaacatcc tctgtgtggg ggagaccggc attggcaaat ccacactgat      420



gaacacactc ttcaacacga ccttcgagac tgaggaagcc agtcaccatg aggcatgcgt      480



gcgcctgcgg ccccagacct atgacctcca ggagagcaac gtgcagctca agctgaccat      540



tgtggatgcc gtgggctttg gggatcagat caataaggat gagagttaca ggcccatagt      600



tgactacatc gatgcgcagt ttgaaaatta tctgcaggag gagctgaaga tccgccgctc      660



gctcttcgac taccatgaca caaggatcca cgtttgcctc tacttcatca cgcccacagg      720



gcactccctg aagtctctag atctagtgac catgaagaaa ctagacagca aggtgaacat      780



tattcccatc atcgccaagg ctgacaccat ctccaagagc gagctccaca agttcaagat      840



caagatcatg ggcgagttgg tcagcaacgg ggtccagatc taccagttcc ccacggatga      900



tgaggctgtt gcagagatta acgcagtcat gaatgcacat ctgccctttg ccgtggtggg      960



cagcaccgag gaggtgaagg tggggaacaa gctggtccga gcacggcagt acccctgggg     1020



agtggtgcag gtggagaatg agaatcactg cgacttcgtg aagctgcggg agatgttgat     1080



ccgggtgaac atggaagacc tccgcgagca gacccacagc cggcactacg agctctaccg     1140



gcgctgcaag ttggaggaga tgggctttca ggacagcgat ggtgacagcc agcccttcag     1200



cctacaagag acatacgagg ccaagaggaa ggagttccta agtgagctgc agaggaagga     1260



ggaagagatg aggcagatgt ttgtcaacaa agtgaaggag acagagctgg agctgaagga     1320



gaaggaaagg gagctccatg agaagtttga gcacctgaag cgggtccacc aggaggagaa     1380



gcgcaaggtg gaggaaaagc gccgggaact ggaggaggag accaacgcct tcaatcgccg     1440



gaaggctgcg gtggaggccc tgcagtcgca ggccttgcac gccacctcgc agcagcccct     1500



gaggaaggac aaggacaaga agaattaacg cacgcacaga cttacatgtc aagagtggac     1560



tttagacttt catgtgttaa gttgcttgag ttacaccttg tgacccttct cccataacat     1620



ggtgtgagga cggactggga gccggtacag actccagtgt ttacagcctt gctttcctcc     1680



caccgaccct ggccccaggc tgccccgggc ctggcgggcc acccctctct atgcaaacac     1740



gtaaaagcca tgaatgctgg aatccaaaac tgacgaggtt tatttttttc agagccagtg     1800



gctggtcttc catttacagt gtcactattc cctgacggag ctgttatgtg ccgctctagc     1860



gaaggcccca gccgggatgc taggcctaat tgttcagcgt ggagatggca actcacgtgg     1920



tgccctaggt gcagctgcgt ggtctggtat acatgctgca aaattcaccc agttcccctc     1980



attttaattt ttctaaccta cagcttaatt ttaataactt taaaacactt ctaaatattt     2040



attttggcac cagcgtcaag acaaataata tcctctccca ttattttcat aagtaacaca     2100



gattccctga tttttaaaaa ctaaaaatac agctaaacct ttcttatgta taaagtatgc     2160



ctatcatata cagggagagg tgggtaataa acttcctgta atgacagtgt ttggcatttc     2220



tttatggatg gaattggaac atgaacaaga ccatgtccag cgtttttact gtgaatgtaa     2280



atggaacagc agcccaaagc tgttgtctgt gccccagagg tgctacctgt agacagggac     2340



caactccatg tgtgtgtgtt aagtgtttga ctccaattaa gactcccaag caaatcctgc     2400



atattccaaa tgtaaagagt actcagtggg aaaaaggttg ttacctcaaa gtcattgctt     2460



ctttcctggc tgggtcacag ggtgaagaga tgaaggtgtc tgatgtatat agacaattag     2520



ggaaaaatga gcggcaaagg agctttcccc ttcagctgca ctctaaaggg gaacatttta     2580



aggaagtact agcagctttg actcttctat gctcctgttg gtttacaagc caccaagaat     2640



gtcagtgttg agaatacggc ctggtaaaat gggagatgta aaatgactaa atgaaaggaa     2700



gggtagtttt aatgttgaag caccgtgctg ggcactggag ctacccagag gaatgcacaa     2760



cgctcccctc aaggagctca cagtctagcc tactccctgg ctggaagcct caggaagacg     2820



tgctaattta ttgtggaatt ggtagtttgc ttttcatgcc cctgtcttcc ttctcatgac     2880



catttccccc tttctgtctg gcttgcatta ttgatttcca ggaccaagtc ctggcttcct     2940



cctgccttcc tgagatgatg ttctgctcag ggagaagtgg aggggtgagc tgtgtgtgtc     3000



caccgaggca cggccaggaa gaggcagcct ttacctgtga ggggctccat gctccagcag     3060



cagagcaggt tctagtgaca attcaacttt ttatgctatg accaggggtg gatctaaatt     3120



ttatggggct gaaagcttga attatttaga aagacttctt taagaaaaac aatgttaata     3180



taaaattagg tacagggtct tggaaggggc cctgaagatt aagcttcctt agcgtcacaa     3240



taagtccgta tctggttgca attgaaaact gatgcttcag tgagggtatc taaaaaggta     3300



aactggcata tccagggcaa atgtgggctg ccaatggctc atctctaggg taattttatg     3360



tctgaaagtg tatgcagttg ggtcagagca tgacctttaa gatagcctct ctcagctaac     3420



atatttatga agatgaggcc tggtgaccca gcaggttcat tggatacata agaaatgaga     3480



attcctggtt catgggccaa cctaggactc tggagtatgc agacttggcc attcgtccat     3540



tgtggcctgc gggtcgcacc ccaggcatac tgaaaggcca tactcgtggc tggctgcctg     3600



cgggcctaag ccttcccagg atcttcagga cacttgacag acttgtgttt tctggtctga     3660



gctgcctcca caggtccctc cagcaagcct cactgcacct ctcccctgct gtttgtgttt     3720



ggaattttgt cttctttagc tgagaccaaa ttaaaccttg gtgcataaag tgagcttaaa     3780



acttgccact gtttagtaag ttagccccca tagaatgtga ccctgtctgc agagtctcat     3840



ttacccctct ttttctcatt gtcatttgtt ggctttatta gggctgtctt acaggatcat     3900



gttggcattt actatcatgt ctttatcata aaccatgttt gtttgaggta gaagaatcac     3960



catataattc gttgcccaaa ttgggactat tgagagagaa aggggatgct attaattaca     4020



ccagatcaaa aggcataaac cagacctgtc ccaggccgat gtggaaatat gttctttcta     4080



gttgtgggta ccctgatcta ggtggtttgt aattgtgcat tactgactgc atatgtttgt     4140



gtatgtgtaa atgtgggctc cctgttaagt ggggctcatg gatacgaggc ctgaggaagt     4200



gtggcttgct agtctgttac gttaacatgc ttttctaaaa ttgcttcacg tgttaattca     4260



tttactcctg cattcattga ctgtttttgt tcttttccat tcactttgta cttatttttt     4320



tcattaaatt ttgcatttat tttg                                            4344





<210>  301

<211>  429

<212>  PRT

<213>  Homo sapiens



<400>  301



Met Ala Ala Thr Asp Leu Glu Arg Phe Ser Asn Ala Glu Pro Glu Pro 

1               5                   10                  15      





Arg Ser Leu Ser Leu Gly Gly His Val Gly Phe Asp Ser Leu Pro Asp 

            20                  25                  30          





Gln Leu Val Ser Lys Ser Val Thr Gln Gly Phe Ser Phe Asn Ile Leu 

        35                  40                  45              





Cys Val Gly Glu Thr Gly Ile Gly Lys Ser Thr Leu Met Asn Thr Leu 

    50                  55                  60                  





Phe Asn Thr Thr Phe Glu Thr Glu Glu Ala Ser His His Glu Ala Cys 

65                  70                  75                  80  





Val Arg Leu Arg Pro Gln Thr Tyr Asp Leu Gln Glu Ser Asn Val Gln 

                85                  90                  95      





Leu Lys Leu Thr Ile Val Asp Ala Val Gly Phe Gly Asp Gln Ile Asn 

            100                 105                 110         





Lys Asp Glu Ser Tyr Arg Pro Ile Val Asp Tyr Ile Asp Ala Gln Phe 

        115                 120                 125             





Glu Asn Tyr Leu Gln Glu Glu Leu Lys Ile Arg Arg Ser Leu Phe Asp 

    130                 135                 140                 





Tyr His Asp Thr Arg Ile His Val Cys Leu Tyr Phe Ile Thr Pro Thr 

145                 150                 155                 160 





Gly His Ser Leu Lys Ser Leu Asp Leu Val Thr Met Lys Lys Leu Asp 

                165                 170                 175     





Ser Lys Val Asn Ile Ile Pro Ile Ile Ala Lys Ala Asp Thr Ile Ser 

            180                 185                 190         





Lys Ser Glu Leu His Lys Phe Lys Ile Lys Ile Met Gly Glu Leu Val 

        195                 200                 205             





Ser Asn Gly Val Gln Ile Tyr Gln Phe Pro Thr Asp Asp Glu Ala Val 

    210                 215                 220                 





Ala Glu Ile Asn Ala Val Met Asn Ala His Leu Pro Phe Ala Val Val 

225                 230                 235                 240 





Gly Ser Thr Glu Glu Val Lys Val Gly Asn Lys Leu Val Arg Ala Arg 

                245                 250                 255     





Gln Tyr Pro Trp Gly Val Val Gln Val Glu Asn Glu Asn His Cys Asp 

            260                 265                 270         





Phe Val Lys Leu Arg Glu Met Leu Ile Arg Val Asn Met Glu Asp Leu 

        275                 280                 285             





Arg Glu Gln Thr His Ser Arg His Tyr Glu Leu Tyr Arg Arg Cys Lys 

    290                 295                 300                 





Leu Glu Glu Met Gly Phe Gln Asp Ser Asp Gly Asp Ser Gln Pro Phe 

305                 310                 315                 320 





Ser Leu Gln Glu Thr Tyr Glu Ala Lys Arg Lys Glu Phe Leu Ser Glu 

                325                 330                 335     





Leu Gln Arg Lys Glu Glu Glu Met Arg Gln Met Phe Val Asn Lys Val 

            340                 345                 350         





Lys Glu Thr Glu Leu Glu Leu Lys Glu Lys Glu Arg Glu Leu His Glu 

        355                 360                 365             





Lys Phe Glu His Leu Lys Arg Val His Gln Glu Glu Lys Arg Lys Val 

    370                 375                 380                 





Glu Glu Lys Arg Arg Glu Leu Glu Glu Glu Thr Asn Ala Phe Asn Arg 

385                 390                 395                 400 





Arg Lys Ala Ala Val Glu Ala Leu Gln Ser Gln Ala Leu His Ala Thr 

                405                 410                 415     





Ser Gln Gln Pro Leu Arg Lys Asp Lys Asp Lys Lys Asn 

            420                 425                 





<210>  302

<211>  6505

<212>  DNA

<213>  Homo sapiens



<400>  302

acagcgcaag ccccacgcca cgcgtcgctg gtcccaggca gcgagtcgct cgcgcgcccc       60



gccgcccgcc tggcgacagc tccgccgcgc acgcacatgg aggggagcgc gagccccccg      120



gaaaagcccc gcgcccgccc tgcggctgcc gtgctgtgcc ggggcccggt agagccgctg      180



gtcttcctgg ccaactttgc cttggtcctg cagggcccgc tcaccacgca gtatctgtgg      240



caccgcttca gcgccgacct cggctacaat ggcacccgcc aaaggggggg ctgcagcaac      300



cgcagcgcgg accccaccat gcaggaagtg gagaccctta cctcccactg gaccctctac      360



atgaacgtgg gcggcttcct ggtggggctc ttctcgtcca ccctgctggg agcttggagc      420



gacagtgtgg gccgccgccc gctgctagtg ctggcctcgc tgggcctgct gctccaggcc      480



ctagtgtccg tttttgtggt gcagctgcag ctccacgtcg gctacttcgt gctgggtcgc      540



atcctttgtg ccctcctcgg cgacttcggt ggccttctgg ctgctagctt tgcgtccgtg      600



gcagatgtca gctccagtcg cagccgcacc ttccggatgg ccctgctgga agccagcatc      660



ggggtggctg ggatgctggc aagcctcctc gggggccact ggctccgggc ccagggttat      720



gccaacccct tctggctggc cttggccttg ctgatagcca tgactctcta tgcagctttc      780



tgctttggtg agaccttaaa ggagccaaag tccacccggc tcttcacgtt ccgtcaccac      840



cgatccattg tccagctcta tgtggctccc gccccagaga agtccaggaa acatttagcc      900



ctctactcac tggccatctt cgtggtgatc actgtgcact ttggggccca ggacatctta      960



accctttatg aactaagcac acccctctgc tgggactcca aactaatcgg ctatggttct     1020



gcagctcagc atctccccta cctcaccagc ctgctggccc tgaagctcct gcagtactgc     1080



ctggccgatg cctgggtagc tgagatcggc ctggccttca acatcctggg gatggtggtc     1140



tttgcctttg ccactatcac gcctctcatg ttcacaggat atgggttgct tttcctgtca     1200



ttagtcatca cacctgtcat ccgggctaaa ctctccaagc tggtgagaga gacagagcag     1260



ggtgctctct tttctgctgt ggcctgtgtg aatagcctgg ccatgctgac ggcctccggc     1320



atcttcaact cactctaccc agccactctg aactttatga aggggttccc cttcctcctg     1380



ggagctggcc tcctgctcat cccggctgtt ctgattggga tgctggaaaa ggctgatcct     1440



cacctcgagt tccagcagtt tccccagagc ccctgatctg cctggaccag aagacagagg     1500



gcaagaggag caaagtgaac accaagcaac tggaggtctg cagctggaag cccagcccac     1560



agcaggacaa gcaactcttg tctaagggca gtgctctctt tggacgaggt agtcaagaga     1620



gaccaaggca ccaccccatc cacagctgac ccagcctctg tctaggatct agaatcataa     1680



cccacacagg cccactgcag gacaggtggc agaggagcta tttgggacag gagtcagttc     1740



tccctttctg ctatccatca cttataaccc cacaggccag aggagaggtc ctgagagagg     1800



tgacacttca gggaccagag gcagcacgag ggctggcatc tctccttcca gcccaaactg     1860



cacagcccca accaggttcc caacacgtgt agcagtcatc agccattcct taacaatgaa     1920



tgtggtacct ggttagtgcc agccttggga aggagggagg gaggtaagag gggcttggtg     1980



atctctggag gaagagtgtt gcctttgctg tggttgggga atcgatcctt ggctatggcc     2040



tacccactcc cctggctgaa gagtgccaat cattacaaat cagcttcagc aaactgaaac     2100



aaaccttctg gtgccttggg ctttggggcc ctctgttttc ctgctcccag tctgcctgcc     2160



atacgttaga caacagaagc tgctgggctg ggcaggagcc ctgagctgcc tggtggattg     2220



gtaccaagtg gggccagcca gggcttctac tgactcgctg tgcaaccttg agcaagcccc     2280



actaggaacg gctagatcag caatgcccca aattgttgaa tcgtggtgat cacatttgga     2340



tggacaagtt aggaaactta gctgattctc tgagatactt cccacttcct catacattct     2400



acaatgagat gcctctcttc atgggcctgg ggaaaggatg aatgagtgtg gctggacttt     2460



tgacctttaa tgtccctgag cagttcttgg cccttgggga gaagtagggg gaggatctgg     2520



ctgactcagc cccaaccgag gggtagcagc tgcagcccag ccaagcagaa caccctggcc     2580



ctacagacct gtgtctgagc aggctttgga ggaaaggcca cttctgagtc ctctgtctca     2640



ggagaagcca ggcctaggtg cttgacctgg tgatctgagc tgtgtttgtc ctagtatggg     2700



tggcagtcac ctctgaacac actggccttg gcttagagga ggcttgtgac ttcagctgtt     2760



ccagctgggg ctggatgctg gactctgatt ccctcagaga gacagaagat cgggcagagg     2820



tcaaccagaa ggccacacag ggcagtggac aacagtggag ggtataccaa atagaaataa     2880



aacgcaggaa acctctctga atactgccct tggggacctc aggagggagt gggactgatt     2940



ggagacaaag agccagaaat catcccctgg agatactcag acactgtatt gttattggcg     3000



ctgtcctgtg agggcagtgt ccaggctgcc ctgcttgtca tatccatgcc ctggctctgg     3060



ccccggtgag cacttgtgct gcatgaggaa aggaggatca ggtggggtca aaaccaaagc     3120



atcgaggctg gcactggcca agacagactc tggcagggag gggagtggaa ggaaggagcc     3180



ccaaacctgg agtgagacct ttgactttct gatgatgtgg ccaagaacta ggagtcacct     3240



ggccagcaca gccaagagtg gggctggggg cgccagcttt aaggtgtcaa cacctggccc     3300



ttgcggggaa agagccttca gcagccccca cggcctggag cctgggttta ttggagggtg     3360



ctttcttacc ctctgaaccc agtggaggag ggggcaatgg gatattcctg ctctgtatgg     3420



cctctgggtc agctttttgt tgcaaaatcc tatcccccgc tgctagattc tttgaagcaa     3480



gggagaagca atagcccagc ctcagaatga ttctcaggaa agcaattcca ctgccagtgg     3540



actgggtgcc aggaggccta ggtctggatc tggggctgcc actaatgaca ggaaagtggg     3600



cttatcctca acctttctga gcctcagtgt cattatctgt aaaatgggga tgataatacc     3660



aggtagagtt gctctgatga ctggagacca tggagcggag tgtttgggaa atggcaaaga     3720



tttgtgaggg cttcgtgctt tagagatttg ctacccttaa ccaccagcat cagctcacct     3780



gggaatctgt aagaaatgca gagtcctagg ccccacccca gatctcctga ttttaacaac     3840



attcccaggt gacttggatg catgttaaag ttggagaagc tgccctaagt gacaaccctt     3900



tgccttttca ggactttgcc tctttccaca gagctgcagg ttctgtctag gctgctttta     3960



ctgccatggg ggctgcctgg tccctgagta agcagtgggt agccctggat ggctgagggg     4020



ctggggaagc cagctgggcc agaccaggaa ggagcctgag gcacagcacc aaggcatggg     4080



gtagggtggg ctttgaggca cggcctcccc atgcccagac ccaggcccaa acaggaggct     4140



cctgtgcacc agcaagtgca gcaaagctgg ctgcagtgac aaggaagtca gagggagggc     4200



tggtttgcct caaccctcgc cctggatgtg gcaaaagata ccacaccgaa ggaagctgta     4260



ggggatctgg gacttagtca ggctagctaa gggcactgag tgattacagg gcaaggccac     4320



agagcggcag gaagttgtaa gtgcaggggc caggcacagt ctgagtggag agccatgatg     4380



gcactcatcc ctggctggct cctgggccca ggcctttgct cagaatacag tgcccaggcc     4440



cgcctgggca ttgccttaat tcctgtctga ggctgccttc cttcatcctc ctcaagctga     4500



ctgctatcag caggagaagg gaatgcagaa ccacccccac cccaactcca gtgtctccag     4560



aactgagcag ggaccctccc catgacggag acagacaacc caatggcagg gcctggggga     4620



gttctaacct cccgtgccca agcctgactt cccttccctc tccagatact gaggaaagtg     4680



ggttggaggt gggccatgag ggtgggggac agggggaggg agagccattt cctaagaaga     4740



gcccaggttg tctcagccca gggagactgg tttcaggagc tgttccttca gaaaggacga     4800



tggaaatgga agtcacagca gggctgggga actggggact ggttaggttg gacccatggg     4860



tgcagcaccc tccaaactgg tgtcagagcc tgcagatgag tcccgggagg agcggccctg     4920



caggaagcgg atgatcttct caatggtggc ctcctggtat tcgtgggacc acctgtgggc     4980



acaggagcca atgtggttca gacagctggg cagagggagc tgctagtcag ctgtttgccc     5040



acactctgcc tgtcatggtg atttgtaccc tacccccctg gtcccagggc cctggggctc     5100



acttgatacc gttgaaagta agcacagcct gcatgtcctc aggcaggacc tggggctcag     5160



gccactcgaa gccatcaatg atgggcacaa tgttcttgcc gcagcttaaa gcagtcacaa     5220



tctcctggag aaagaaagga aaggaggaag atacccctgt acccatctag ggacccttgt     5280



agccaggcag gtgctgggag gcccactggc ccgaggctgg gcccagggca ggacaccagt     5340



cctgatgtcc accttgatgt ctaccttaac ccttgtagtg taataaaaaa taaatatttt     5400



tcctttgccc agagttcctg gcacagagct gctaaaaccc ttggaatctc ttgagtgatg     5460



agtgtctttg tatgctaaag agatgattcc ccactggggg cccggggggt gctatggggg     5520



tagcctagat agtttcagga agagggctgg tcaccaggga gaccagggca tgactagagg     5580



attggaactt tcagccccac ctcccagcct ccagagaggt gctggagatt gagttcaatc     5640



accaatggcc aatgatttaa tcaatcatgc ctacataatg gaacctccat aaaaaccccc     5700



aaacaagggg ttttgaagag cctccaggtt gataaacagg tgtaggtgct gggaaggtgg     5760



tagaaggcat ggcatccaca cctccaccct ccatacgtag agatcctatg tatctcttcc     5820



atttggctat tcttgagctg tgtcctttat aactgtgaaa ttaaataatt cagctgggca     5880



tggtgggtca cgcctgtaat cccaacactt tgggaggctg aggcaggagg atcacttgag     5940



cccaggattt tgagattaat aatattattt attactatta ttcaagcttt gttaaatcaa     6000



acctaaagct cttggaactt taagttattc tgagccttga caggaattgg tctctgcagc     6060



ctgagtcatg gggcatgcag ctgcaacttc cacctatttt ttttttttct gtaattactt     6120



aggaagacca aatggcacca gagataagac tcccttagat ccccacttag atcaccaccc     6180



tttctcaggg ggtaataaag tcatcttcct tggaatgtag caatctataa ccaatcaaag     6240



cactgtaaca tacgcactgg tcttgtatgg aaaatgttgt aatcctgcta aaattcctct     6300



ctctttgcct gtggaagtga aaccttaact tctccagttt ggaatgctca ccccatgcct     6360



ttggagtcaa tgcttactgg gtggctattc tcaaactttg cactcaaaga aactctatac     6420



ttagtcttat tttctgaatc tcattattta aggttgacat aataaacaac taatagtaag     6480



taaagtgaaa aaaaaaaaaa aaaaa                                           6505





<210>  303

<211>  459

<212>  PRT

<213>  Homo sapiens



<400>  303



Met Glu Gly Ser Ala Ser Pro Pro Glu Lys Pro Arg Ala Arg Pro Ala 

1               5                   10                  15      





Ala Ala Val Leu Cys Arg Gly Pro Val Glu Pro Leu Val Phe Leu Ala 

            20                  25                  30          





Asn Phe Ala Leu Val Leu Gln Gly Pro Leu Thr Thr Gln Tyr Leu Trp 

        35                  40                  45              





His Arg Phe Ser Ala Asp Leu Gly Tyr Asn Gly Thr Arg Gln Arg Gly 

    50                  55                  60                  





Gly Cys Ser Asn Arg Ser Ala Asp Pro Thr Met Gln Glu Val Glu Thr 

65                  70                  75                  80  





Leu Thr Ser His Trp Thr Leu Tyr Met Asn Val Gly Gly Phe Leu Val 

                85                  90                  95      





Gly Leu Phe Ser Ser Thr Leu Leu Gly Ala Trp Ser Asp Ser Val Gly 

            100                 105                 110         





Arg Arg Pro Leu Leu Val Leu Ala Ser Leu Gly Leu Leu Leu Gln Ala 

        115                 120                 125             





Leu Val Ser Val Phe Val Val Gln Leu Gln Leu His Val Gly Tyr Phe 

    130                 135                 140                 





Val Leu Gly Arg Ile Leu Cys Ala Leu Leu Gly Asp Phe Gly Gly Leu 

145                 150                 155                 160 





Leu Ala Ala Ser Phe Ala Ser Val Ala Asp Val Ser Ser Ser Arg Ser 

                165                 170                 175     





Arg Thr Phe Arg Met Ala Leu Leu Glu Ala Ser Ile Gly Val Ala Gly 

            180                 185                 190         





Met Leu Ala Ser Leu Leu Gly Gly His Trp Leu Arg Ala Gln Gly Tyr 

        195                 200                 205             





Ala Asn Pro Phe Trp Leu Ala Leu Ala Leu Leu Ile Ala Met Thr Leu 

    210                 215                 220                 





Tyr Ala Ala Phe Cys Phe Gly Glu Thr Leu Lys Glu Pro Lys Ser Thr 

225                 230                 235                 240 





Arg Leu Phe Thr Phe Arg His His Arg Ser Ile Val Gln Leu Tyr Val 

                245                 250                 255     





Ala Pro Ala Pro Glu Lys Ser Arg Lys His Leu Ala Leu Tyr Ser Leu 

            260                 265                 270         





Ala Ile Phe Val Val Ile Thr Val His Phe Gly Ala Gln Asp Ile Leu 

        275                 280                 285             





Thr Leu Tyr Glu Leu Ser Thr Pro Leu Cys Trp Asp Ser Lys Leu Ile 

    290                 295                 300                 





Gly Tyr Gly Ser Ala Ala Gln His Leu Pro Tyr Leu Thr Ser Leu Leu 

305                 310                 315                 320 





Ala Leu Lys Leu Leu Gln Tyr Cys Leu Ala Asp Ala Trp Val Ala Glu 

                325                 330                 335     





Ile Gly Leu Ala Phe Asn Ile Leu Gly Met Val Val Phe Ala Phe Ala 

            340                 345                 350         





Thr Ile Thr Pro Leu Met Phe Thr Gly Tyr Gly Leu Leu Phe Leu Ser 

        355                 360                 365             





Leu Val Ile Thr Pro Val Ile Arg Ala Lys Leu Ser Lys Leu Val Arg 

    370                 375                 380                 





Glu Thr Glu Gln Gly Ala Leu Phe Ser Ala Val Ala Cys Val Asn Ser 

385                 390                 395                 400 





Leu Ala Met Leu Thr Ala Ser Gly Ile Phe Asn Ser Leu Tyr Pro Ala 

                405                 410                 415     





Thr Leu Asn Phe Met Lys Gly Phe Pro Phe Leu Leu Gly Ala Gly Leu 

            420                 425                 430         





Leu Leu Ile Pro Ala Val Leu Ile Gly Met Leu Glu Lys Ala Asp Pro 

        435                 440                 445             





His Leu Glu Phe Gln Gln Phe Pro Gln Ser Pro 

    450                 455                 





<210>  304

<211>  10238

<212>  DNA

<213>  Homo sapiens



<400>  304

ggattcctcc agtccctccc tcggccgcct ctcctcccgg agcgagcgcg cagccctgcg       60



cagcagcgcc cactggtccc gtcctgtgag ccccggcccc agccgcggac agacccgcgg      120



agtcgcctcc cggcccaccc gcccggccgc cgaggagcgg gaggaggacg ggaccccggc      180



gcccccaccc catccccggg agaactctaa gaaggagctg atgtggagga gcagctgaga      240



cagttcaaga tgacgaccac agtagccaca gactatgaca acattgagat ccagcagcag      300



tacagtgatg tcaacaaccg ctgggatgtc gacgactggg acaatgagaa cagctctgcg      360



cggctttttg agcggtcccg catcaaggct ctggcagatg agcgtgaagc cgtgcagaag      420



aagaccttca ccaagtgggt caattcccac cttgcccgtg tgtcctgccg gatcacagac      480



ctgtacactg accttcgaga tggacggatg ctcatcaagc tgctggaggt cctctctgga      540



gagaggctgc ctaaacccac caagggacga atgcgcatcc actgcttaga gaatgtggac      600



aaggcccttc agttcctgaa ggagcagaga gtccatcttg agaacatggg gtcccatgac      660



atcgtggatg gaaaccaccg gctgaccctt ggcctcatct ggaccatcat cctgcgcttc      720



cagatccagg atatcagtgt ggaaactgaa gacaacaaag agaagaaatc tgccaaggat      780



gcattgctgt tgtggtgcca gatgaagaca gctgggtacc ccaatgtcaa cattcacaat      840



ttcaccacta gctggaggga cggcatggcc ttcaatgcac tgatacacaa acaccggcct      900



gacctgatag attttgacaa actaaagaaa tctaacgcac actacaacct gcagaatgca      960



tttaatctgg cagaacagca cctcggcctc actaaactgt tggaccccga agacatcagc     1020



gtggaccatc ctgatgagaa gtccataatc acttatgtgg tgacttatta ccactacttc     1080



tctaagatga aggccttagc tgttgaagga aaacgaattg gaaaggtgct tgacaatgct     1140



attgaaacag aaaaaatgat tgaaaagtat gaatcacttg cctctgacct tctggaatgg     1200



attgaacaaa ccatcatcat tctgaacaat cgcaaatttg ccaattcact ggtcggggtt     1260



caacagcagc ttcaggcatt caacacttac cgcactgtgg agaaaccacc caaatttact     1320



gagaagggga acttggaagt gctgctcttc accattcaga gcaagatgag ggccaacaac     1380



cagaaggtct acatgccccg ggaggggaag ctcatctctg acatcaacaa ggcctgggaa     1440



agactggaaa aagcggaaca cgaaagagaa ctggctttgc ggaatgagct cataagacag     1500



gagaaactgg aacagctcgc ccgcagattt gatcgcaagg cagctatgag ggagacttgg     1560



ctgagcgaaa accagcgtct ggtgtctcag gacaactttg ggtttgacct tcctgcagtt     1620



gaggccgcca caaaaaagca cgaggccatt gagacagaca ttgccgcata cgaggagcgt     1680



gtgcaggctg tggtagccgt ggccagggag ctcgaggccg agaattacca cgacatcaag     1740



cgcatcacag cgaggaagga caatgtcatc cggctctggg aatacctact ggaactgctc     1800



agggcccgga gacagcggct cgagatgaac ctggggctgc agaagatatt ccaggaaatg     1860



ctctacatta tggactggat ggatgaaatg aaggtgctag tattgtctca agactatggc     1920



aaacacttac ttggtgtgga agacctgtta cagaagcaca ccctggttga agcagacatt     1980



ggcatccagg cagagcgggt gagaggtgtc aatgcctccg cccagaagtt cgcaacagac     2040



ggggaaggtt acaagccctg tgacccccag gtgatccgag accgcgtggc ccacatggag     2100



ttctgttatc aagagctttg ccagctggcg gctgagcgca gggcccgtct ggaagagtcc     2160



cgccgcctct ggaagttctt ctgggagatg gcagaagagg aaggctggat acgggagaag     2220



gagaagatcc tgtcctcgga cgattacggg aaagacctga ccagcgtcat gcgcctgctc     2280



agcaagcacc gggcgttcga ggacgagatg agcggccgca gtggccactt tgagcaggcc     2340



atcaaggaag gcgaagacat gatcgcggag gagcacttcg ggtcggagaa gatccgtgag     2400



aggatcattt acatccggga gcagtgggcc aacctagagc agctctcggc cattcggaag     2460



aagcgcctgg aggaggcctc cctgctgcac cagttccagg cagatgctga tgacattgat     2520



gcctggatgc tggacatcct caagattgtc tccagcagcg acgtgggcca cgatgagtat     2580



tccacacagt ctctggtcaa gaaacacaag gacgtggcgg aagagatcgc caattacagg     2640



cccacccttg acacgctgca cgaacaagcc agcgccctcc cccaggagca tgccgagtct     2700



ccagacgtga ggggcaggct gtcgggcatc gaggagcggt ataaggaggt ggcagagctg     2760



acgcggctgc ggaagcaggc actccaggac actctggccc tgtacaagat gttcagcgag     2820



gctgatgcct gtgagctctg gatcgacgag aaggagcagt ggctcaacaa catgcagatc     2880



ccagagaagc tggaggatct ggaggtcatc cagcacagat ttgagagcct agaaccagaa     2940



atgaacaacc aggcttcccg ggttgcagtg gtgaaccaga ttgcacgcca gctgatgcac     3000



agcggccacc caagtgagaa ggaaatcaaa gcccagcagg acaaactcaa cacaaggtgg     3060



agccagttca gagaactggt tgacaggaag aaggatgccc tcctgtctgc cctgagcatc     3120



cagaactacc acctcgagtg caatgaaacc aaatcctgga ttcgggaaaa gaccaaggtc     3180



atcgagtcca cccaggacct gggcaatgac ctggctggcg tcatggccct gcagcgcaag     3240



ctgaccggca tggagcggga cttggtggcc attgaggcaa agctgagtga cctgcagaag     3300



gaggcggaga agctggagtc cgagcacccc gaccaggccc aggccatcct gtctcggctg     3360



gccgagatca gcgacgtgtg ggaggagatg aagaccaccc tgaaaaaccg agaggcctcc     3420



ctgggagagg ccagcaagct gcagcagttc ctacgggact tggacgactt ccagtcctgg     3480



ctctctagga cccagacagc gatcgcctcg gaggacatgc caaacaccct gaccgaggct     3540



gagaagctgc tcacgcagca cgagaacatc aagaacgaga tcgacaacta cgaggaggac     3600



taccagaaga tgagggacat gggcgagatg gtcacccagg ggcagaccga tgcccagtac     3660



atgtttctgc ggcagcggct gcaggccctg gacactggat ggaacgagct ccacaagatg     3720



tgggagaaca gacaaaatct cctatcccag tcacatgcct accagcagtt cctcagagac     3780



acgaagcaag ccgaagcctt tcttaacaac caggagtatg ttctggctca cactgaaatg     3840



cctaccacct tggaaggagc tgaagcagca attaaaaagc aagaggactt catgaccacc     3900



atggacgcca atgaggagaa gatcaatgct gtggtggaga ctggccggag gctggtgagc     3960



gatgggaaca tcaactcaga tcgcatccag gagaaggtgg actctattga tgacagacat     4020



aggaagaatc gtgagacagc cagtgaactt ttgatgaggt tgaaggacaa cagggatcta     4080



cagaaattcc tgcaagattg tcaagagctg tctctctgga tcaatgagaa gatgctcaca     4140



gcccaggaca tgtcttacga tgaagccaga aatctgcaca gtaaatggtt gaagcatcaa     4200



gcatttatgg cagaacttgc atccaacaaa gaatggcttg acaaaatcga gaaggaagga     4260



atgcagctca tttcagaaaa gcctgagacg gaagctgtgg tgaaggagaa actcactggt     4320



ttacataaaa tgtgggaagt ccttgaatcc actacccaga caaaggccca gcggctcttt     4380



gatgcaaaca aggccgaact tttcacccag agctgtgcag atctagacaa atggctgcac     4440



ggcctggaga gtcagattca gtctgatgac tatggcaaag acctgaccag tgtcaatatc     4500



ctgctgaaaa agcaacagat gctggagaat cagatggaag tgcggaagaa ggagatcgaa     4560



gagctccaaa gccaagccca ggccctgagt caggaaggga agagcaccga cgaggtagac     4620



agcaagcgcc tcaccgtgca gaccaagttc atggagttgc tggagccctt gaacgagagg     4680



aagcataacc tgctggcctc caaagagatc catcagttca acagggatgt ggaggacgag     4740



atcttgtggg ttggagagag gatgcctttg gcaacttcca cggatcatgg ccacaacctc     4800



cagactgtgc agctgttaat aaagaaaaat cagaccctcc agaaagaaat ccaggggcac     4860



cagcctcgca ttgacgacat ctttgagagg agccaaaaca tcgtcactga cagcagcagc     4920



ctcagcgctg aggccatcag acagaggctt gccgacctga agcagctgtg gggtctcctc     4980



attgaggaga cagagaaacg ccacaggcgg ctggaggagg cgcacagggc ccagcagtac     5040



tactttgacg ctgctgaggc cgaagcctgg atgagcgagc aggagctgta catgatgtca     5100



gaggagaagg ccaaggatga gcagagtgct gtctccatgt tgaagaagca ccagatctta     5160



gaacaagctg tggaggacta tgcagagacc gtgcatcagc tctccaagac cagccgggcc     5220



ctggtggccg acagccatcc tgaaagtgag cgcattagca tgcggcagtc caaagtggat     5280



aaactgtacg ctggtctgaa agaccttgct gaagagagaa gaggcaagct ggatgagaga     5340



cacaggttat tccagctcaa ccgggaggtg gacgacctgg agcagtggat cgctgagagg     5400



gaggtggtcg cagggtccca tgaactggga caggactatg agcatgtcac gatgttacaa     5460



gaacgattcc gggagtttgc ccgagacacc gggaacattg ggcaggagcg cgtggacacg     5520



gtcaatcacc tggcagatga gctcatcaac tctggacatt cagatgccgc caccatcgct     5580



gaatggaagg atggcctcaa tgaagcctgg gccgacctcc tggagctcat tgacacaaga     5640



acacagattc ttgccgcttc ctatgaactg cacaagtttt accacgatgc caaggagatc     5700



tttgggcgta tacaggacaa acacaagaaa ctccctgagg agcttgggag agatcagaac     5760



acagtggaga ccttacagag aatgcacact acatttgagc atgacatcca ggctctgggc     5820



acacaggtga ggcagctgca ggaggatgca gcccgcctcc aggcggccta tgcgggtgac     5880



aaggccgacg atatccagaa gcgcgagaac gaggtcctgg aagcctggaa gtccctcctg     5940



gacgcctgtg agagccgcag ggtgcggctg gtggacacag gggacaagtt ccgcttcttc     6000



agcatggtgc gcgacctcat gctctggatg gaggatgtca tccggcagat cgaggcccag     6060



gagaagccaa gggatgtatc atctgttgaa ctcttaatga ataatcatca aggcatcaaa     6120



gctgaaattg atgcacgtaa tgacagtttc acaacctgca ttgaacttgg gaaatccctg     6180



ttggcgagaa aacactatgc atctgaggag atcaaggaaa aattactgca gttgacggaa     6240



aagaggaaag aaatgatcga caagtgggaa gaccgatggg aatggttaag actgattctg     6300



gaggtccatc agttctcaag agacgccagt gtggccgagg cctggctgct tggacaggag     6360



ccgtacctat ccagccgaga gataggccag agcgtggacg aggtggagaa gctcatcaag     6420



cgccacgagg catttgaaaa gtctgcagca acctgggatg agaggttctc tgccctggaa     6480



aggctgacta cattggagtt actggaagtg cgcagacagc aagaggaaga ggagaggaag     6540



aggcggccgc cttctcccga gccgagcacg aaggtttcag aggaagccga gtcccagcag     6600



cagtgggata cttcaaaagg agaacaagtt tcccaaaacg gtttgccagc tgaacaggga     6660



tctccacgga tggcagaaac ggtggacaca agcgaaatgg tcaacggcgc tacagaacaa     6720



aggacgagct ctaaagagtc cagccccatc ccctccccga cctctgatcg taaagccaag     6780



actgccctcc cagcccagag tgccgccacc ttaccagcca gaacccagga gacaccttcg     6840



gcccagatgg aaggcttcct caatcggaaa cacgagtggg aggcccacaa taagaaagcc     6900



tcaagcaggt cctggcacaa tgtttattgt gtcataaata accaagaaat gggtttctac     6960



aaagatgcaa agactgctgc ttctggaatt ccctaccaca gcgaggtccc tgtgagtttg     7020



aaagaagctg tctgcgaagt ggcccttgat tacaaaaaga agaaacacgt attcaagcta     7080



agactaaatg atggcaatga gtacctcttc caagccaaag acgatgagga aatgaacaca     7140



tggatccagg ctatctcttc cgccatctcc tctgataaac acgaggtgtc tgccagcacc     7200



cagagcacgc cagcatccag ccgcgcgcag accctcccca ccagcgtcgt caccatcacc     7260



agcgagtcca gtcccggcaa gcgggaaaag gacaaagaga aagacaaaga gaagcggttc     7320



agcctttttg gcaaaaagaa atgaactcct ttccttcacc tcctgccctt ctcttacctt     7380



ttcagtgaaa ttccagcatg caagctcaga accaacacat tactctctgt gcctaatgtt     7440



cctcaatgtg gttgattttt tttttttttt aatttataga gcatttcggg gggggtgggg     7500



gaaacacacc taaacacttt atctccaagt tacaaaagtt tgaggtgcag agggaaggcc     7560



agattttttt tttaatgaaa ttatatagat tagatctcag tatttaaact gttcctcaat     7620



tttgtgaggc tgtgttggaa ataacccgcc tctagtgctg ttggtatgca aggcagcggt     7680



gcttaatcaa tatttcctgt gctcaccaga ggcaaaatgt accaatatcc tgacaccatt     7740



ctctctccat ttacttctgg tggttaccct gactcttgac tcttagaagt gcccgagatg     7800



gggctaacct ttattaaaca gatcgcatat tatgatcttg ctgcagccac agtgcagctc     7860



cacattaact ctacagacca aaccatttgt atctggcatc acttactaac acacgacatg     7920



cggcttttct gcatcaactg ctatgacggt taagaatgtc agtatacaag aaggaataga     7980



aaactgatac tgttttaaat aatctgtaat ttcaattttt tttttttgct gaaatacatt     8040



atattgtacg tttgagataa ttctagtaca aagtataata aaactagatg tataataaac     8100



cctttaaatc attggtaagt gtacaagtgg tggaactgaa gcatttactg gacaaagtaa     8160



tgttactcta atggttactt gctcgtgcgt tgccacactg tgttataatt tgcttcattt     8220



ccttgctatt tgatacatag tgtgcatttc tctgtcactg taactattgt aatgacaaat     8280



tttcatctta ctgcacaatc aaaatgacat tgataggaat gaactccaga ggctgggcct     8340



gaacagggag gtggtcgctc aggcctggtg ctcagtcgta cgacctgtac ctctcaactt     8400



ttgccctatc tgttaaatat atgctatgtc attaaatgct tttaaatcta gcacggtgac     8460



tagttgttgt tcttcctctg ctgcgtgtgc atgcccagta gggaaactgc aaagggagaa     8520



atgacaaaca agaaacattt tacaaccagt ctgggctcac ttttgcattt tttatgcatg     8580



tctggtgcac aagctttgaa aactacagca aacagtaata aatgtgactg ttttgtagtt     8640



atacattcag gctttatctt ttatttatga aaaagttacc agagcacttg tgaaacctga     8700



actctgagat aggggttggc aaatttgttc tgtaaaggga cagagatagt aaatatttta     8760



ggctttgtag gccgtaactg tctctgttgc tcaattctgc tgttgcgtaa tacaaaggca     8820



gccattgacg gtatgtgaat gcctgggcat ggctgtgttc cagtaaaact atttaaggac     8880



ataaatttga atttcatata actttgacat gccatacaat attttgattt tcttaatgat     8940



ttcaaaatgt aaagtctatt ttatacagat cagaccaaaa agaagaaaaa aaaaaaacag     9000



gcaagaggtt aggtttggcc catgggccat agtttgctga cttcagcata gagtcgtggg     9060



ttatttacaa gtgacatact tttcctgggt tatctgggta tgttgactcc atgccacttg     9120



cataaagcag caatggatat tagtattatg gatgtccagt aagttattcc acaaagacca     9180



tgcctaaggt ggcatcagcc ctgggctcca cagctgcgtg gcatcaaagc tttctcttaa     9240



ctctcttacc tctaggcaaa ctgagacctc accatcctct cccctgcttc ccacgacagt     9300



cctttgccct tgccatgctc agggttggaa tcaagttgtt ctattctcaa cagaccaaaa     9360



tgtttagtta aggcaaagta tcttggaaac aattgtgatt aattacagtc ttgtactctt     9420



gacaaagctg tgcagatggc aataagttca taccagcaat cctggagtcc cataataaat     9480



acgtacatgt ggaacatcgt gcacataatt tcaacagttc gcagatctgt agttatgaag     9540



ccagggtttg gtggtatttg ctctctcttg gtgcatttga taaggatcca ctgaggcctg     9600



aatgtggaag atgatgggca gcgagaggag cgtcagaaga ccccagtcaa gacgtgttcg     9660



ccatcagagg ttacaggccg cacagcctga tgagcttcaa gcctggcagg gtaaatagtt     9720



tttgggtttt ttgttttttt tttattcttc cactatcatg ttttttgagg attttgcata     9780



tttcttgttg ccataatgct gtgctatttt accctgattt tcagtgatac aatatgggtg     9840



acaatactgg cccctccata aatctgaaga gtaagaagta gtgaaaataa ggcttaggat     9900



atgaaatggc gttgtcactt gaatcaaggc cactttttgt cctacttgag catctcaagt     9960



tgggatgcat cttctgatgg cacttccgga actggctgtg gtttttttgg gtgtaccgag    10020



agtgccagtg actgtgcttc ttacaattcc tggcatcttg agtaggtgaa acactgtatc    10080



agactgggtg atgggcacat tgtcatttca ccaagttcct ggaactgtta gaattgcttg    10140



tgtatgggga tcctatgtta gttcccctgg atacattgtt ttatcagtcg gaattcttaa    10200



ataaagacat acttcccttc aaaaaaaaaa aaaaaaaa                            10238





<210>  305

<211>  2364

<212>  PRT

<213>  Homo sapiens



<400>  305



Met Thr Thr Thr Val Ala Thr Asp Tyr Asp Asn Ile Glu Ile Gln Gln 

1               5                   10                  15      





Gln Tyr Ser Asp Val Asn Asn Arg Trp Asp Val Asp Asp Trp Asp Asn 

            20                  25                  30          





Glu Asn Ser Ser Ala Arg Leu Phe Glu Arg Ser Arg Ile Lys Ala Leu 

        35                  40                  45              





Ala Asp Glu Arg Glu Ala Val Gln Lys Lys Thr Phe Thr Lys Trp Val 

    50                  55                  60                  





Asn Ser His Leu Ala Arg Val Ser Cys Arg Ile Thr Asp Leu Tyr Thr 

65                  70                  75                  80  





Asp Leu Arg Asp Gly Arg Met Leu Ile Lys Leu Leu Glu Val Leu Ser 

                85                  90                  95      





Gly Glu Arg Leu Pro Lys Pro Thr Lys Gly Arg Met Arg Ile His Cys 

            100                 105                 110         





Leu Glu Asn Val Asp Lys Ala Leu Gln Phe Leu Lys Glu Gln Arg Val 

        115                 120                 125             





His Leu Glu Asn Met Gly Ser His Asp Ile Val Asp Gly Asn His Arg 

    130                 135                 140                 





Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu Arg Phe Gln Ile Gln 

145                 150                 155                 160 





Asp Ile Ser Val Glu Thr Glu Asp Asn Lys Glu Lys Lys Ser Ala Lys 

                165                 170                 175     





Asp Ala Leu Leu Leu Trp Cys Gln Met Lys Thr Ala Gly Tyr Pro Asn 

            180                 185                 190         





Val Asn Ile His Asn Phe Thr Thr Ser Trp Arg Asp Gly Met Ala Phe 

        195                 200                 205             





Asn Ala Leu Ile His Lys His Arg Pro Asp Leu Ile Asp Phe Asp Lys 

    210                 215                 220                 





Leu Lys Lys Ser Asn Ala His Tyr Asn Leu Gln Asn Ala Phe Asn Leu 

225                 230                 235                 240 





Ala Glu Gln His Leu Gly Leu Thr Lys Leu Leu Asp Pro Glu Asp Ile 

                245                 250                 255     





Ser Val Asp His Pro Asp Glu Lys Ser Ile Ile Thr Tyr Val Val Thr 

            260                 265                 270         





Tyr Tyr His Tyr Phe Ser Lys Met Lys Ala Leu Ala Val Glu Gly Lys 

        275                 280                 285             





Arg Ile Gly Lys Val Leu Asp Asn Ala Ile Glu Thr Glu Lys Met Ile 

    290                 295                 300                 





Glu Lys Tyr Glu Ser Leu Ala Ser Asp Leu Leu Glu Trp Ile Glu Gln 

305                 310                 315                 320 





Thr Ile Ile Ile Leu Asn Asn Arg Lys Phe Ala Asn Ser Leu Val Gly 

                325                 330                 335     





Val Gln Gln Gln Leu Gln Ala Phe Asn Thr Tyr Arg Thr Val Glu Lys 

            340                 345                 350         





Pro Pro Lys Phe Thr Glu Lys Gly Asn Leu Glu Val Leu Leu Phe Thr 

        355                 360                 365             





Ile Gln Ser Lys Met Arg Ala Asn Asn Gln Lys Val Tyr Met Pro Arg 

    370                 375                 380                 





Glu Gly Lys Leu Ile Ser Asp Ile Asn Lys Ala Trp Glu Arg Leu Glu 

385                 390                 395                 400 





Lys Ala Glu His Glu Arg Glu Leu Ala Leu Arg Asn Glu Leu Ile Arg 

                405                 410                 415     





Gln Glu Lys Leu Glu Gln Leu Ala Arg Arg Phe Asp Arg Lys Ala Ala 

            420                 425                 430         





Met Arg Glu Thr Trp Leu Ser Glu Asn Gln Arg Leu Val Ser Gln Asp 

        435                 440                 445             





Asn Phe Gly Phe Asp Leu Pro Ala Val Glu Ala Ala Thr Lys Lys His 

    450                 455                 460                 





Glu Ala Ile Glu Thr Asp Ile Ala Ala Tyr Glu Glu Arg Val Gln Ala 

465                 470                 475                 480 





Val Val Ala Val Ala Arg Glu Leu Glu Ala Glu Asn Tyr His Asp Ile 

                485                 490                 495     





Lys Arg Ile Thr Ala Arg Lys Asp Asn Val Ile Arg Leu Trp Glu Tyr 

            500                 505                 510         





Leu Leu Glu Leu Leu Arg Ala Arg Arg Gln Arg Leu Glu Met Asn Leu 

        515                 520                 525             





Gly Leu Gln Lys Ile Phe Gln Glu Met Leu Tyr Ile Met Asp Trp Met 

    530                 535                 540                 





Asp Glu Met Lys Val Leu Val Leu Ser Gln Asp Tyr Gly Lys His Leu 

545                 550                 555                 560 





Leu Gly Val Glu Asp Leu Leu Gln Lys His Thr Leu Val Glu Ala Asp 

                565                 570                 575     





Ile Gly Ile Gln Ala Glu Arg Val Arg Gly Val Asn Ala Ser Ala Gln 

            580                 585                 590         





Lys Phe Ala Thr Asp Gly Glu Gly Tyr Lys Pro Cys Asp Pro Gln Val 

        595                 600                 605             





Ile Arg Asp Arg Val Ala His Met Glu Phe Cys Tyr Gln Glu Leu Cys 

    610                 615                 620                 





Gln Leu Ala Ala Glu Arg Arg Ala Arg Leu Glu Glu Ser Arg Arg Leu 

625                 630                 635                 640 





Trp Lys Phe Phe Trp Glu Met Ala Glu Glu Glu Gly Trp Ile Arg Glu 

                645                 650                 655     





Lys Glu Lys Ile Leu Ser Ser Asp Asp Tyr Gly Lys Asp Leu Thr Ser 

            660                 665                 670         





Val Met Arg Leu Leu Ser Lys His Arg Ala Phe Glu Asp Glu Met Ser 

        675                 680                 685             





Gly Arg Ser Gly His Phe Glu Gln Ala Ile Lys Glu Gly Glu Asp Met 

    690                 695                 700                 





Ile Ala Glu Glu His Phe Gly Ser Glu Lys Ile Arg Glu Arg Ile Ile 

705                 710                 715                 720 





Tyr Ile Arg Glu Gln Trp Ala Asn Leu Glu Gln Leu Ser Ala Ile Arg 

                725                 730                 735     





Lys Lys Arg Leu Glu Glu Ala Ser Leu Leu His Gln Phe Gln Ala Asp 

            740                 745                 750         





Ala Asp Asp Ile Asp Ala Trp Met Leu Asp Ile Leu Lys Ile Val Ser 

        755                 760                 765             





Ser Ser Asp Val Gly His Asp Glu Tyr Ser Thr Gln Ser Leu Val Lys 

    770                 775                 780                 





Lys His Lys Asp Val Ala Glu Glu Ile Ala Asn Tyr Arg Pro Thr Leu 

785                 790                 795                 800 





Asp Thr Leu His Glu Gln Ala Ser Ala Leu Pro Gln Glu His Ala Glu 

                805                 810                 815     





Ser Pro Asp Val Arg Gly Arg Leu Ser Gly Ile Glu Glu Arg Tyr Lys 

            820                 825                 830         





Glu Val Ala Glu Leu Thr Arg Leu Arg Lys Gln Ala Leu Gln Asp Thr 

        835                 840                 845             





Leu Ala Leu Tyr Lys Met Phe Ser Glu Ala Asp Ala Cys Glu Leu Trp 

    850                 855                 860                 





Ile Asp Glu Lys Glu Gln Trp Leu Asn Asn Met Gln Ile Pro Glu Lys 

865                 870                 875                 880 





Leu Glu Asp Leu Glu Val Ile Gln His Arg Phe Glu Ser Leu Glu Pro 

                885                 890                 895     





Glu Met Asn Asn Gln Ala Ser Arg Val Ala Val Val Asn Gln Ile Ala 

            900                 905                 910         





Arg Gln Leu Met His Ser Gly His Pro Ser Glu Lys Glu Ile Lys Ala 

        915                 920                 925             





Gln Gln Asp Lys Leu Asn Thr Arg Trp Ser Gln Phe Arg Glu Leu Val 

    930                 935                 940                 





Asp Arg Lys Lys Asp Ala Leu Leu Ser Ala Leu Ser Ile Gln Asn Tyr 

945                 950                 955                 960 





His Leu Glu Cys Asn Glu Thr Lys Ser Trp Ile Arg Glu Lys Thr Lys 

                965                 970                 975     





Val Ile Glu Ser Thr Gln Asp Leu Gly Asn Asp Leu Ala Gly Val Met 

            980                 985                 990         





Ala Leu Gln Arg Lys Leu Thr Gly  Met Glu Arg Asp Leu  Val Ala Ile 

        995                 1000                 1005             





Glu Ala  Lys Leu Ser Asp Leu  Gln Lys Glu Ala Glu  Lys Leu Glu 

    1010                 1015                 1020             





Ser Glu  His Pro Asp Gln Ala  Gln Ala Ile Leu Ser  Arg Leu Ala 

    1025                 1030                 1035             





Glu Ile  Ser Asp Val Trp Glu  Glu Met Lys Thr Thr  Leu Lys Asn 

    1040                 1045                 1050             





Arg Glu  Ala Ser Leu Gly Glu  Ala Ser Lys Leu Gln  Gln Phe Leu 

    1055                 1060                 1065             





Arg Asp  Leu Asp Asp Phe Gln  Ser Trp Leu Ser Arg  Thr Gln Thr 

    1070                 1075                 1080             





Ala Ile  Ala Ser Glu Asp Met  Pro Asn Thr Leu Thr  Glu Ala Glu 

    1085                 1090                 1095             





Lys Leu  Leu Thr Gln His Glu  Asn Ile Lys Asn Glu  Ile Asp Asn 

    1100                 1105                 1110             





Tyr Glu  Glu Asp Tyr Gln Lys  Met Arg Asp Met Gly  Glu Met Val 

    1115                 1120                 1125             





Thr Gln  Gly Gln Thr Asp Ala  Gln Tyr Met Phe Leu  Arg Gln Arg 

    1130                 1135                 1140             





Leu Gln  Ala Leu Asp Thr Gly  Trp Asn Glu Leu His  Lys Met Trp 

    1145                 1150                 1155             





Glu Asn  Arg Gln Asn Leu Leu  Ser Gln Ser His Ala  Tyr Gln Gln 

    1160                 1165                 1170             





Phe Leu  Arg Asp Thr Lys Gln  Ala Glu Ala Phe Leu  Asn Asn Gln 

    1175                 1180                 1185             





Glu Tyr  Val Leu Ala His Thr  Glu Met Pro Thr Thr  Leu Glu Gly 

    1190                 1195                 1200             





Ala Glu  Ala Ala Ile Lys Lys  Gln Glu Asp Phe Met  Thr Thr Met 

    1205                 1210                 1215             





Asp Ala  Asn Glu Glu Lys Ile  Asn Ala Val Val Glu  Thr Gly Arg 

    1220                 1225                 1230             





Arg Leu  Val Ser Asp Gly Asn  Ile Asn Ser Asp Arg  Ile Gln Glu 

    1235                 1240                 1245             





Lys Val  Asp Ser Ile Asp Asp  Arg His Arg Lys Asn  Arg Glu Thr 

    1250                 1255                 1260             





Ala Ser  Glu Leu Leu Met Arg  Leu Lys Asp Asn Arg  Asp Leu Gln 

    1265                 1270                 1275             





Lys Phe  Leu Gln Asp Cys Gln  Glu Leu Ser Leu Trp  Ile Asn Glu 

    1280                 1285                 1290             





Lys Met  Leu Thr Ala Gln Asp  Met Ser Tyr Asp Glu  Ala Arg Asn 

    1295                 1300                 1305             





Leu His  Ser Lys Trp Leu Lys  His Gln Ala Phe Met  Ala Glu Leu 

    1310                 1315                 1320             





Ala Ser  Asn Lys Glu Trp Leu  Asp Lys Ile Glu Lys  Glu Gly Met 

    1325                 1330                 1335             





Gln Leu  Ile Ser Glu Lys Pro  Glu Thr Glu Ala Val  Val Lys Glu 

    1340                 1345                 1350             





Lys Leu  Thr Gly Leu His Lys  Met Trp Glu Val Leu  Glu Ser Thr 

    1355                 1360                 1365             





Thr Gln  Thr Lys Ala Gln Arg  Leu Phe Asp Ala Asn  Lys Ala Glu 

    1370                 1375                 1380             





Leu Phe  Thr Gln Ser Cys Ala  Asp Leu Asp Lys Trp  Leu His Gly 

    1385                 1390                 1395             





Leu Glu  Ser Gln Ile Gln Ser  Asp Asp Tyr Gly Lys  Asp Leu Thr 

    1400                 1405                 1410             





Ser Val  Asn Ile Leu Leu Lys  Lys Gln Gln Met Leu  Glu Asn Gln 

    1415                 1420                 1425             





Met Glu  Val Arg Lys Lys Glu  Ile Glu Glu Leu Gln  Ser Gln Ala 

    1430                 1435                 1440             





Gln Ala  Leu Ser Gln Glu Gly  Lys Ser Thr Asp Glu  Val Asp Ser 

    1445                 1450                 1455             





Lys Arg  Leu Thr Val Gln Thr  Lys Phe Met Glu Leu  Leu Glu Pro 

    1460                 1465                 1470             





Leu Asn  Glu Arg Lys His Asn  Leu Leu Ala Ser Lys  Glu Ile His 

    1475                 1480                 1485             





Gln Phe  Asn Arg Asp Val Glu  Asp Glu Ile Leu Trp  Val Gly Glu 

    1490                 1495                 1500             





Arg Met  Pro Leu Ala Thr Ser  Thr Asp His Gly His  Asn Leu Gln 

    1505                 1510                 1515             





Thr Val  Gln Leu Leu Ile Lys  Lys Asn Gln Thr Leu  Gln Lys Glu 

    1520                 1525                 1530             





Ile Gln  Gly His Gln Pro Arg  Ile Asp Asp Ile Phe  Glu Arg Ser 

    1535                 1540                 1545             





Gln Asn  Ile Val Thr Asp Ser  Ser Ser Leu Ser Ala  Glu Ala Ile 

    1550                 1555                 1560             





Arg Gln  Arg Leu Ala Asp Leu  Lys Gln Leu Trp Gly  Leu Leu Ile 

    1565                 1570                 1575             





Glu Glu  Thr Glu Lys Arg His  Arg Arg Leu Glu Glu  Ala His Arg 

    1580                 1585                 1590             





Ala Gln  Gln Tyr Tyr Phe Asp  Ala Ala Glu Ala Glu  Ala Trp Met 

    1595                 1600                 1605             





Ser Glu  Gln Glu Leu Tyr Met  Met Ser Glu Glu Lys  Ala Lys Asp 

    1610                 1615                 1620             





Glu Gln  Ser Ala Val Ser Met  Leu Lys Lys His Gln  Ile Leu Glu 

    1625                 1630                 1635             





Gln Ala  Val Glu Asp Tyr Ala  Glu Thr Val His Gln  Leu Ser Lys 

    1640                 1645                 1650             





Thr Ser  Arg Ala Leu Val Ala  Asp Ser His Pro Glu  Ser Glu Arg 

    1655                 1660                 1665             





Ile Ser  Met Arg Gln Ser Lys  Val Asp Lys Leu Tyr  Ala Gly Leu 

    1670                 1675                 1680             





Lys Asp  Leu Ala Glu Glu Arg  Arg Gly Lys Leu Asp  Glu Arg His 

    1685                 1690                 1695             





Arg Leu  Phe Gln Leu Asn Arg  Glu Val Asp Asp Leu  Glu Gln Trp 

    1700                 1705                 1710             





Ile Ala  Glu Arg Glu Val Val  Ala Gly Ser His Glu  Leu Gly Gln 

    1715                 1720                 1725             





Asp Tyr  Glu His Val Thr Met  Leu Gln Glu Arg Phe  Arg Glu Phe 

    1730                 1735                 1740             





Ala Arg  Asp Thr Gly Asn Ile  Gly Gln Glu Arg Val  Asp Thr Val 

    1745                 1750                 1755             





Asn His  Leu Ala Asp Glu Leu  Ile Asn Ser Gly His  Ser Asp Ala 

    1760                 1765                 1770             





Ala Thr  Ile Ala Glu Trp Lys  Asp Gly Leu Asn Glu  Ala Trp Ala 

    1775                 1780                 1785             





Asp Leu  Leu Glu Leu Ile Asp  Thr Arg Thr Gln Ile  Leu Ala Ala 

    1790                 1795                 1800             





Ser Tyr  Glu Leu His Lys Phe  Tyr His Asp Ala Lys  Glu Ile Phe 

    1805                 1810                 1815             





Gly Arg  Ile Gln Asp Lys His  Lys Lys Leu Pro Glu  Glu Leu Gly 

    1820                 1825                 1830             





Arg Asp  Gln Asn Thr Val Glu  Thr Leu Gln Arg Met  His Thr Thr 

    1835                 1840                 1845             





Phe Glu  His Asp Ile Gln Ala  Leu Gly Thr Gln Val  Arg Gln Leu 

    1850                 1855                 1860             





Gln Glu  Asp Ala Ala Arg Leu  Gln Ala Ala Tyr Ala  Gly Asp Lys 

    1865                 1870                 1875             





Ala Asp  Asp Ile Gln Lys Arg  Glu Asn Glu Val Leu  Glu Ala Trp 

    1880                 1885                 1890             





Lys Ser  Leu Leu Asp Ala Cys  Glu Ser Arg Arg Val  Arg Leu Val 

    1895                 1900                 1905             





Asp Thr  Gly Asp Lys Phe Arg  Phe Phe Ser Met Val  Arg Asp Leu 

    1910                 1915                 1920             





Met Leu  Trp Met Glu Asp Val  Ile Arg Gln Ile Glu  Ala Gln Glu 

    1925                 1930                 1935             





Lys Pro  Arg Asp Val Ser Ser  Val Glu Leu Leu Met  Asn Asn His 

    1940                 1945                 1950             





Gln Gly  Ile Lys Ala Glu Ile  Asp Ala Arg Asn Asp  Ser Phe Thr 

    1955                 1960                 1965             





Thr Cys  Ile Glu Leu Gly Lys  Ser Leu Leu Ala Arg  Lys His Tyr 

    1970                 1975                 1980             





Ala Ser  Glu Glu Ile Lys Glu  Lys Leu Leu Gln Leu  Thr Glu Lys 

    1985                 1990                 1995             





Arg Lys  Glu Met Ile Asp Lys  Trp Glu Asp Arg Trp  Glu Trp Leu 

    2000                 2005                 2010             





Arg Leu  Ile Leu Glu Val His  Gln Phe Ser Arg Asp  Ala Ser Val 

    2015                 2020                 2025             





Ala Glu  Ala Trp Leu Leu Gly  Gln Glu Pro Tyr Leu  Ser Ser Arg 

    2030                 2035                 2040             





Glu Ile  Gly Gln Ser Val Asp  Glu Val Glu Lys Leu  Ile Lys Arg 

    2045                 2050                 2055             





His Glu  Ala Phe Glu Lys Ser  Ala Ala Thr Trp Asp  Glu Arg Phe 

    2060                 2065                 2070             





Ser Ala  Leu Glu Arg Leu Thr  Thr Leu Glu Leu Leu  Glu Val Arg 

    2075                 2080                 2085             





Arg Gln  Gln Glu Glu Glu Glu  Arg Lys Arg Arg Pro  Pro Ser Pro 

    2090                 2095                 2100             





Glu Pro  Ser Thr Lys Val Ser  Glu Glu Ala Glu Ser  Gln Gln Gln 

    2105                 2110                 2115             





Trp Asp  Thr Ser Lys Gly Glu  Gln Val Ser Gln Asn  Gly Leu Pro 

    2120                 2125                 2130             





Ala Glu  Gln Gly Ser Pro Arg  Met Ala Glu Thr Val  Asp Thr Ser 

    2135                 2140                 2145             





Glu Met  Val Asn Gly Ala Thr  Glu Gln Arg Thr Ser  Ser Lys Glu 

    2150                 2155                 2160             





Ser Ser  Pro Ile Pro Ser Pro  Thr Ser Asp Arg Lys  Ala Lys Thr 

    2165                 2170                 2175             





Ala Leu  Pro Ala Gln Ser Ala  Ala Thr Leu Pro Ala  Arg Thr Gln 

    2180                 2185                 2190             





Glu Thr  Pro Ser Ala Gln Met  Glu Gly Phe Leu Asn  Arg Lys His 

    2195                 2200                 2205             





Glu Trp  Glu Ala His Asn Lys  Lys Ala Ser Ser Arg  Ser Trp His 

    2210                 2215                 2220             





Asn Val  Tyr Cys Val Ile Asn  Asn Gln Glu Met Gly  Phe Tyr Lys 

    2225                 2230                 2235             





Asp Ala  Lys Thr Ala Ala Ser  Gly Ile Pro Tyr His  Ser Glu Val 

    2240                 2245                 2250             





Pro Val  Ser Leu Lys Glu Ala  Val Cys Glu Val Ala  Leu Asp Tyr 

    2255                 2260                 2265             





Lys Lys  Lys Lys His Val Phe  Lys Leu Arg Leu Asn  Asp Gly Asn 

    2270                 2275                 2280             





Glu Tyr  Leu Phe Gln Ala Lys  Asp Asp Glu Glu Met  Asn Thr Trp 

    2285                 2290                 2295             





Ile Gln  Ala Ile Ser Ser Ala  Ile Ser Ser Asp Lys  His Glu Val 

    2300                 2305                 2310             





Ser Ala  Ser Thr Gln Ser Thr  Pro Ala Ser Ser Arg  Ala Gln Thr 

    2315                 2320                 2325             





Leu Pro  Thr Ser Val Val Thr  Ile Thr Ser Glu Ser  Ser Pro Gly 

    2330                 2335                 2340             





Lys Arg  Glu Lys Asp Lys Glu  Lys Asp Lys Glu Lys  Arg Phe Ser 

    2345                 2350                 2355             





Leu Phe  Gly Lys Lys Lys 

    2360                 





<210>  306

<211>  9091

<212>  DNA

<213>  Homo sapiens



<400>  306

ggtgtgcgcg ctgcgcccgc gagctcccgg gctcggcaac cgtggcatgc ttaggattgg       60



ccatatttaa aagttctgaa gtagaacctg cgcctcctct ctgcttctcc ctcctcctca      120



gtaatttatt tcgagcttcc aggcaagggc cacggaagaa gggaaagcaa gaaattagat      180



gcctgtgtgg taactcctcg cggagctaag gtggactctc ttgcagccaa cttcccatca      240



gatcaccctg ctggacttgc agaccggaat ggggctcgcc taaggagccg agcgctgcgg      300



aggctgctgc gtgttggatg ggagtgggag ggggctggag cgagatttcc agggcgcagt      360



cctccggggc gttacgccgg gcataatgga attgcagagg acgtctagta tctccgggcc      420



gctgtcgccg gcgtacacgg ggcaggtgcc ttacaactac aaccagctgg aaggcagatt      480



caagcagctg caagatgagc gtgaagccgt gcagaagaag accttcacca agtgggtcaa      540



ttcccacctt gcccgtgtgt cctgccggat cacagacctg tacactgacc ttcgagatgg      600



acggatgctc atcaagctgc tggaggtcct ctctggagag aggctgccta aacccaccaa      660



gggacgaatg cgcatccact gcttagagaa tgtggacaag gcccttcagt tcctgaagga      720



gcagagagtc catcttgaga acatggggtc ccatgacatc gtggatggaa accaccggct      780



gacccttggc ctcatctgga ccatcatcct gcgcttccag atccaggata tcagtgtgga      840



aactgaagac aacaaagaga agaaatctgc caaggatgca ttgctgttgt ggtgccagat      900



gaagacagct gggtacccca atgtcaacat tcacaatttc accactagct ggagggacgg      960



catggccttc aatgcactga tacacaaaca ccggcctgac ctgatagatt ttgacaaact     1020



aaagaaatct aacgcacact acaacctgca gaatgcattt aatctggcag aacagcacct     1080



cggcctcact aaactgttgg accccgaaga catcagcgtg gaccatcctg atgagaagtc     1140



cataatcact tatgtggtga cttattacca ctacttctct aagatgaagg ccttagctgt     1200



tgaaggaaaa cgaattggaa aggtgcttga caatgctatt gaaacagaaa aaatgattga     1260



aaagtatgaa tcacttgcct ctgaccttct ggaatggatt gaacaaacca tcatcattct     1320



gaacaatcgc aaatttgcca attcactggt cggggttcaa cagcagcttc aggcattcaa     1380



cacttaccgc actgtggaga aaccacccaa atttactgag aaggggaact tggaagtgct     1440



gctcttcacc attcagagca agatgagggc caacaaccag aaggtctaca tgccccggga     1500



ggggaagctc atctctgaca tcaacaaggc ctgggaaaga ctggaaaaag cggaacacga     1560



aagagaactg gctttgcgga atgagctcat aagacaggag aaactggaac agctcgcccg     1620



cagatttgat cgcaaggcag ctatgaggga gacttggctg agcgaaaacc agcgtctggt     1680



gtctcaggac aactttgggt ttgaccttcc tgcagttgag gccgccacaa aaaagcacga     1740



ggccattgag acagacattg ccgcatacga ggagcgtgtg caggctgtgg tagccgtggc     1800



cagggagctc gaggccgaga attaccacga catcaagcgc atcacagcga ggaaggacaa     1860



tgtcatccgg ctctgggaat acctactgga actgctcagg gcccggagac agcggctcga     1920



gatgaacctg gggctgcaga agatattcca ggaaatgctc tacattatgg actggatgga     1980



tgaaatgaag gtgctagtat tgtctcaaga ctatggcaaa cacttacttg gtgtggaaga     2040



cctgttacag aagcacaccc tggttgaagc agacattggc atccaggcag agcgggtgag     2100



aggtgtcaat gcctccgccc agaagttcgc aacagacggg gaaggttaca agccctgtga     2160



cccccaggtg atccgagacc gcgtggccca catggagttc tgttatcaag agctttgcca     2220



gctggcggct gagcgcaggg cccgtctgga agagtcccgc cgcctctgga agttcttctg     2280



ggagatggca gaagaggaag gctggatacg ggagaaggag aagatcctgt cctcggacga     2340



ttacgggaaa gacctgacca gcgtcatgcg cctgctcagc aagcaccggg cgttcgagga     2400



cgagatgagc ggccgcagtg gccactttga gcaggccatc aaggaaggcg aagacatgat     2460



cgcggaggag cacttcgggt cggagaagat ccgtgagagg atcatttaca tccgggagca     2520



gtgggccaac ctagagcagc tctcggccat tcggaagaag cgcctggagg aggcctccct     2580



gctgcaccag ttccaggcag atgctgatga cattgatgcc tggatgctgg acatcctcaa     2640



gattgtctcc agcagcgacg tgggccacga tgagtattcc acacagtctc tggtcaagaa     2700



acacaaggac gtggcggaag agatcgccaa ttacaggccc acccttgaca cgctgcacga     2760



acaagccagc gccctccccc aggagcatgc cgagtctcca gacgtgaggg gcaggctgtc     2820



gggcatcgag gagcggtata aggaggtggc agagctgacg cggctgcgga agcaggcact     2880



ccaggacact ctggccctgt acaagatgtt cagcgaggct gatgcctgtg agctctggat     2940



cgacgagaag gagcagtggc tcaacaacat gcagatccca gagaagctgg aggatctgga     3000



ggtcatccag cacagatttg agagcctaga accagaaatg aacaaccagg cttcccgggt     3060



tgcagtggtg aaccagattg cacgccagct gatgcacagc ggccacccaa gtgagaagga     3120



aatcaaagcc cagcaggaca aactcaacac aaggtggagc cagttcagag aactggttga     3180



caggaagaag gatgccctcc tgtctgccct gagcatccag aactaccacc tcgagtgcaa     3240



tgaaaccaaa tcctggattc gggaaaagac caaggtcatc gagtccaccc aggacctggg     3300



caatgacctg gctggcgtca tggccctgca gcgcaagctg accggcatgg agcgggactt     3360



ggtggccatt gaggcaaagc tgagtgacct gcagaaggag gcggagaagc tggagtccga     3420



gcaccccgac caggcccagg ccatcctgtc tcggctggcc gagatcagcg acgtgtggga     3480



ggagatgaag accaccctga aaaaccgaga ggcctccctg ggagaggcca gcaagctgca     3540



gcagttccta cgggacttgg acgacttcca gtcctggctc tctaggaccc agacagcgat     3600



cgcctcggag gacatgccaa acaccctgac cgaggctgag aagctgctca cgcagcacga     3660



gaacatcaag aacgagatcg acaactacga ggaggactac cagaagatga gggacatggg     3720



cgagatggtc acccaggggc agaccgatgc ccagtacatg tttctgcggc agcggctgca     3780



ggccctggac actggatgga acgagctcca caagatgtgg gagaacagac aaaatctcct     3840



atcccagtca catgcctacc agcagttcct cagagacacg aagcaagccg aagcctttct     3900



taacaaccag gagtatgttc tggctcacac tgaaatgcct accaccttgg aaggagctga     3960



agcagcaatt aaaaagcaag aggacttcat gaccaccatg gacgccaatg aggagaagat     4020



caatgctgtg gtggagactg gccggaggct ggtgagcgat gggaacatca actcagatcg     4080



catccaggag aaggtggact ctattgatga cagacatagg aagaatcgtg agacagccag     4140



tgaacttttg atgaggttga aggacaacag ggatctacag aaattcctgc aagattgtca     4200



agagctgtct ctctggatca atgagaagat gctcacagcc caggacatgt cttacgatga     4260



agccagaaat ctgcacagta aatggttgaa gcatcaagca tttatggcag aacttgcatc     4320



caacaaagaa tggcttgaca aaatcgagaa ggaaggaatg cagctcattt cagaaaagcc     4380



tgagacggaa gctgtggtga aggagaaact cactggttta cataaaatgt gggaagtcct     4440



tgaatccact acccagacaa aggcccagcg gctctttgat gcaaacaagg ccgaactttt     4500



cacccagagc tgtgcagatc tagacaaatg gctgcacggc ctggagagtc agattcagtc     4560



tgatgactat ggcaaagacc tgaccagtgt caatatcctg ctgaaaaagc aacagatgct     4620



ggagaatcag atggaagtgc ggaagaagga gatcgaagag ctccaaagcc aagcccaggc     4680



cctgagtcag gaagggaaga gcaccgacga ggtagacagc aagcgcctca ccgtgcagac     4740



caagttcatg gagttgctgg agcccttgaa cgagaggaag cataacctgc tggcctccaa     4800



agagatccat cagttcaaca gggatgtgga ggacgagatc ttgtgggttg gagagaggat     4860



gcctttggca acttccacgg atcatggcca caacctccag actgtgcagc tgttaataaa     4920



gaaaaatcag accctccaga aagaaatcca ggggcaccag cctcgcattg acgacatctt     4980



tgagaggagc caaaacatcg tcactgacag cagcagcctc agcgctgagg ccatcagaca     5040



gaggcttgcc gacctgaagc agctgtgggg tctcctcatt gaggagacag agaaacgcca     5100



caggcggctg gaggaggcgc acagggccca gcagtactac tttgacgctg ctgaggccga     5160



agcctggatg agcgagcagg agctgtacat gatgtcagag gagaaggcca aggatgagca     5220



gagtgctgtc tccatgttga agaagcacca gatcttagaa caagctgtgg aggactatgc     5280



agagaccgtg catcagctct ccaagaccag ccgggccctg gtggccgaca gccatcctga     5340



aagtgagcgc attagcatgc ggcagtccaa agtggataaa ctgtacgctg gtctgaaaga     5400



ccttgctgaa gagagaagag gcaagctgga tgagagacac aggttattcc agctcaaccg     5460



ggaggtggac gacctggagc agtggatcgc tgagagggag gtggtcgcag ggtcccatga     5520



actgggacag gactatgagc atgtcacgat gttacaagaa cgattccggg agtttgcccg     5580



agacaccggg aacattgggc aggagcgcgt ggacacggtc aatcacctgg cagatgagct     5640



catcaactct ggacattcag atgccgccac catcgctgaa tggaaggatg gcctcaatga     5700



agcctgggcc gacctcctgg agctcattga cacaagaaca cagattcttg ccgcttccta     5760



tgaactgcac aagttttacc acgatgccaa ggagatcttt gggcgtatac aggacaaaca     5820



caagaaactc cctgaggagc ttgggagaga tcagaacaca gtggagacct tacagagaat     5880



gcacactaca tttgagcatg acatccaggc tctgggcaca caggtgaggc agctgcagga     5940



ggatgcagcc cgcctccagg cggcctatgc gggtgacaag gccgacgata tccagaagcg     6000



cgagaacgag gtcctggaag cctggaagtc cctcctggac gcctgtgaga gccgcagggt     6060



gcggctggtg gacacagggg acaagttccg cttcttcagc atggtgcgcg acctcatgct     6120



ctggatggag gatgtcatcc ggcagatcga ggcccaggag aagccaaggg atgtatcatc     6180



tgttgaactc ttaatgaata atcatcaagg catcaaagct gaaattgatg cacgtaatga     6240



cagtttcaca acctgcattg aacttgggaa atccctgttg gcgagaaaac actatgcatc     6300



tgaggagatc aaggaaaaat tactgcagtt gacggaaaag aggaaagaaa tgatcgacaa     6360



gtgggaagac cgatgggaat ggttaagact gattctggag gtccatcagt tctcaagaga     6420



cgccagtgtg gccgaggcct ggctgcttgg acaggagccg tacctatcca gccgagagat     6480



aggccagagc gtggacgagg tggagaagct catcaagcgc cacgaggcat ttgaaaagtc     6540



tgcagcaacc tgggatgaga ggttctctgc cctggaaagg ctgactacat tggagttact     6600



ggaagtgcgc agacagcaag aggaagagga gaggaagagg cggccgcctt ctcccgagcc     6660



gagcacgaag gtttcagagg aagccgagtc ccagcagcag tgggatactt caaaaggaga     6720



acaagtttcc caaaacggtt tgccagctga acagggatct ccacgggtta gttaccgctc     6780



tcaaacctac caaaactaca aaaactttaa tagcagacgg acagccagtg accagccatg     6840



gtctggactg tgaagttcac taccatttgt caagaatcac cctttccaaa tcctctgggt     6900



tttgactttt tggcttccac ttcacccaaa atgttaaaat ttttacttaa ttcatagcct     6960



tccttggttt catatttgtt tgcatttaat tcatgtttga gtctcttaac tgatggatgc     7020



ccacttgcct taaagcagca tacttatttt ttgtttattt attgtgagct ttttacttta     7080



ttaagatttt acagcgaaac ccttacatga gtaattgaaa tgaaattaaa tgagattaca     7140



gcataatgaa gaagaaaact agaatctaac aggtatgaca cattcagtta ttctaacagg     7200



gcacagtact gtgctatatg tagccgcctt tacagatgtt attaacctat agtagtttac     7260



tattaactag gaagactggt gtatgaggag ggagacattc tgtaataaga ttaaaaccta     7320



aagtcagctg tgtaacattc catgaaagat gcattcattt attgaagatg acaaaaaagg     7380



gagtcagata tattctggaa gctattttaa ttttaggcac acaatctcat acattttgag     7440



acccttgggt catttattac tttttacaaa ctagttcctc tctttttttc tgccaagtcc     7500



tgaattgaaa actgtaggct tccttgcaca gatgttgcag ccagcctcag gagtaaagtg     7560



cccgctgact gctgccgcca cctctgtctc gctccctgtc agtgctgctg gcacgtggga     7620



cgcggcaggt gacagccgtt ctcagcatgt tttagaagct tgcctcacag acttccatgc     7680



ctctccattc agccgatgac ttcagggtgt caaactgttt taatttttca aacaaatgga     7740



acagaagcca ttgtggttca tcctgattac ttgaacgttg cacttggtgg accgtgcctg     7800



ggagcgctcg catgccccct ggcttcagaa gtcatgtcag tgtctctgta gacaaactcc     7860



actgtacatc ttggattaat cttctgattc attgttcatt ttctcaagac tttttgtgga     7920



attctctgat aaaggaagct tttaggatgg tatctatcag gccaccagca ggaattgaaa     7980



atgttttcac aaaaatcctt ttccttagaa ataaaagctg gtgacagaga tggtttcctt     8040



gtaccgataa aaacaaaacc aaatccatat tatacatcaa aaccttgtga gacattcact     8100



tgctcttttg ccatatttag atgtgtcagt ggaatcagaa acctgttttg atatgtgttc     8160



tctatgagtt aagtctgatt tgtcttttta tttcatgatg catgtctttt ttttcttttg     8220



tcaggataac gtcatatagc atcttgtttg tttttcctta tctctatgta catatctatc     8280



tacttctgac tgtagatggg tatatagata gatgccaagc ttcttatgtt ctgggggtag     8340



tatgcatcat tattgggtct ctgccttaaa acacatcaaa attcatttta gacaaaaaaa     8400



cttctgcttt gtctttggtc attagggagc tctaatgtgt gtttgtggct ccaagttaca     8460



ttttgtgttt cattgatcta tatgtatata tgtgatgttt tcatatatat atgtgtgtgt     8520



gtttaaattt tgtatcatca ggactgacac ccaatttgac actttttgta tctagaagac     8580



cctccaaaaa aggaaccaca taagcacaca agaaaagagt gctatgatgt tcttagcatt     8640



tgctatcatg cctattttta tctagatttt taaatgtagc ttgtcataac aaaattttaa     8700



ttacaattgg cttgtatgag aagaaaaagt atttttattg ttttgagtga tgacgcagag     8760



actcagtgaa cttgaaaata gcattgcttc gtgcactttg aataccaatc aggtgttttc     8820



tgtgctacta gttgtcacgt tgcattcatg ttcacctcct gatttaagta tctcgggtgt     8880



gcccagccac taaagcactc tggactaatc gctaaagaga agcaacgtgg ggggtggggt     8940



tgcgagggat gtgttcacat gtacccatca tttgatcata gcactgtgat tgcttttgat     9000



gtgtgtctct agtggtgtgc tgtctgttgg catgcttaaa gcacatgtcc attaaaattc     9060



attttgttcc ttttaaaaaa aaaaaaaaaa a                                    9091





<210>  307

<211>  2155

<212>  PRT

<213>  Homo sapiens



<400>  307



Met Glu Leu Gln Arg Thr Ser Ser Ile Ser Gly Pro Leu Ser Pro Ala 

1               5                   10                  15      





Tyr Thr Gly Gln Val Pro Tyr Asn Tyr Asn Gln Leu Glu Gly Arg Phe 

            20                  25                  30          





Lys Gln Leu Gln Asp Glu Arg Glu Ala Val Gln Lys Lys Thr Phe Thr 

        35                  40                  45              





Lys Trp Val Asn Ser His Leu Ala Arg Val Ser Cys Arg Ile Thr Asp 

    50                  55                  60                  





Leu Tyr Thr Asp Leu Arg Asp Gly Arg Met Leu Ile Lys Leu Leu Glu 

65                  70                  75                  80  





Val Leu Ser Gly Glu Arg Leu Pro Lys Pro Thr Lys Gly Arg Met Arg 

                85                  90                  95      





Ile His Cys Leu Glu Asn Val Asp Lys Ala Leu Gln Phe Leu Lys Glu 

            100                 105                 110         





Gln Arg Val His Leu Glu Asn Met Gly Ser His Asp Ile Val Asp Gly 

        115                 120                 125             





Asn His Arg Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu Arg Phe 

    130                 135                 140                 





Gln Ile Gln Asp Ile Ser Val Glu Thr Glu Asp Asn Lys Glu Lys Lys 

145                 150                 155                 160 





Ser Ala Lys Asp Ala Leu Leu Leu Trp Cys Gln Met Lys Thr Ala Gly 

                165                 170                 175     





Tyr Pro Asn Val Asn Ile His Asn Phe Thr Thr Ser Trp Arg Asp Gly 

            180                 185                 190         





Met Ala Phe Asn Ala Leu Ile His Lys His Arg Pro Asp Leu Ile Asp 

        195                 200                 205             





Phe Asp Lys Leu Lys Lys Ser Asn Ala His Tyr Asn Leu Gln Asn Ala 

    210                 215                 220                 





Phe Asn Leu Ala Glu Gln His Leu Gly Leu Thr Lys Leu Leu Asp Pro 

225                 230                 235                 240 





Glu Asp Ile Ser Val Asp His Pro Asp Glu Lys Ser Ile Ile Thr Tyr 

                245                 250                 255     





Val Val Thr Tyr Tyr His Tyr Phe Ser Lys Met Lys Ala Leu Ala Val 

            260                 265                 270         





Glu Gly Lys Arg Ile Gly Lys Val Leu Asp Asn Ala Ile Glu Thr Glu 

        275                 280                 285             





Lys Met Ile Glu Lys Tyr Glu Ser Leu Ala Ser Asp Leu Leu Glu Trp 

    290                 295                 300                 





Ile Glu Gln Thr Ile Ile Ile Leu Asn Asn Arg Lys Phe Ala Asn Ser 

305                 310                 315                 320 





Leu Val Gly Val Gln Gln Gln Leu Gln Ala Phe Asn Thr Tyr Arg Thr 

                325                 330                 335     





Val Glu Lys Pro Pro Lys Phe Thr Glu Lys Gly Asn Leu Glu Val Leu 

            340                 345                 350         





Leu Phe Thr Ile Gln Ser Lys Met Arg Ala Asn Asn Gln Lys Val Tyr 

        355                 360                 365             





Met Pro Arg Glu Gly Lys Leu Ile Ser Asp Ile Asn Lys Ala Trp Glu 

    370                 375                 380                 





Arg Leu Glu Lys Ala Glu His Glu Arg Glu Leu Ala Leu Arg Asn Glu 

385                 390                 395                 400 





Leu Ile Arg Gln Glu Lys Leu Glu Gln Leu Ala Arg Arg Phe Asp Arg 

                405                 410                 415     





Lys Ala Ala Met Arg Glu Thr Trp Leu Ser Glu Asn Gln Arg Leu Val 

            420                 425                 430         





Ser Gln Asp Asn Phe Gly Phe Asp Leu Pro Ala Val Glu Ala Ala Thr 

        435                 440                 445             





Lys Lys His Glu Ala Ile Glu Thr Asp Ile Ala Ala Tyr Glu Glu Arg 

    450                 455                 460                 





Val Gln Ala Val Val Ala Val Ala Arg Glu Leu Glu Ala Glu Asn Tyr 

465                 470                 475                 480 





His Asp Ile Lys Arg Ile Thr Ala Arg Lys Asp Asn Val Ile Arg Leu 

                485                 490                 495     





Trp Glu Tyr Leu Leu Glu Leu Leu Arg Ala Arg Arg Gln Arg Leu Glu 

            500                 505                 510         





Met Asn Leu Gly Leu Gln Lys Ile Phe Gln Glu Met Leu Tyr Ile Met 

        515                 520                 525             





Asp Trp Met Asp Glu Met Lys Val Leu Val Leu Ser Gln Asp Tyr Gly 

    530                 535                 540                 





Lys His Leu Leu Gly Val Glu Asp Leu Leu Gln Lys His Thr Leu Val 

545                 550                 555                 560 





Glu Ala Asp Ile Gly Ile Gln Ala Glu Arg Val Arg Gly Val Asn Ala 

                565                 570                 575     





Ser Ala Gln Lys Phe Ala Thr Asp Gly Glu Gly Tyr Lys Pro Cys Asp 

            580                 585                 590         





Pro Gln Val Ile Arg Asp Arg Val Ala His Met Glu Phe Cys Tyr Gln 

        595                 600                 605             





Glu Leu Cys Gln Leu Ala Ala Glu Arg Arg Ala Arg Leu Glu Glu Ser 

    610                 615                 620                 





Arg Arg Leu Trp Lys Phe Phe Trp Glu Met Ala Glu Glu Glu Gly Trp 

625                 630                 635                 640 





Ile Arg Glu Lys Glu Lys Ile Leu Ser Ser Asp Asp Tyr Gly Lys Asp 

                645                 650                 655     





Leu Thr Ser Val Met Arg Leu Leu Ser Lys His Arg Ala Phe Glu Asp 

            660                 665                 670         





Glu Met Ser Gly Arg Ser Gly His Phe Glu Gln Ala Ile Lys Glu Gly 

        675                 680                 685             





Glu Asp Met Ile Ala Glu Glu His Phe Gly Ser Glu Lys Ile Arg Glu 

    690                 695                 700                 





Arg Ile Ile Tyr Ile Arg Glu Gln Trp Ala Asn Leu Glu Gln Leu Ser 

705                 710                 715                 720 





Ala Ile Arg Lys Lys Arg Leu Glu Glu Ala Ser Leu Leu His Gln Phe 

                725                 730                 735     





Gln Ala Asp Ala Asp Asp Ile Asp Ala Trp Met Leu Asp Ile Leu Lys 

            740                 745                 750         





Ile Val Ser Ser Ser Asp Val Gly His Asp Glu Tyr Ser Thr Gln Ser 

        755                 760                 765             





Leu Val Lys Lys His Lys Asp Val Ala Glu Glu Ile Ala Asn Tyr Arg 

    770                 775                 780                 





Pro Thr Leu Asp Thr Leu His Glu Gln Ala Ser Ala Leu Pro Gln Glu 

785                 790                 795                 800 





His Ala Glu Ser Pro Asp Val Arg Gly Arg Leu Ser Gly Ile Glu Glu 

                805                 810                 815     





Arg Tyr Lys Glu Val Ala Glu Leu Thr Arg Leu Arg Lys Gln Ala Leu 

            820                 825                 830         





Gln Asp Thr Leu Ala Leu Tyr Lys Met Phe Ser Glu Ala Asp Ala Cys 

        835                 840                 845             





Glu Leu Trp Ile Asp Glu Lys Glu Gln Trp Leu Asn Asn Met Gln Ile 

    850                 855                 860                 





Pro Glu Lys Leu Glu Asp Leu Glu Val Ile Gln His Arg Phe Glu Ser 

865                 870                 875                 880 





Leu Glu Pro Glu Met Asn Asn Gln Ala Ser Arg Val Ala Val Val Asn 

                885                 890                 895     





Gln Ile Ala Arg Gln Leu Met His Ser Gly His Pro Ser Glu Lys Glu 

            900                 905                 910         





Ile Lys Ala Gln Gln Asp Lys Leu Asn Thr Arg Trp Ser Gln Phe Arg 

        915                 920                 925             





Glu Leu Val Asp Arg Lys Lys Asp Ala Leu Leu Ser Ala Leu Ser Ile 

    930                 935                 940                 





Gln Asn Tyr His Leu Glu Cys Asn Glu Thr Lys Ser Trp Ile Arg Glu 

945                 950                 955                 960 





Lys Thr Lys Val Ile Glu Ser Thr Gln Asp Leu Gly Asn Asp Leu Ala 

                965                 970                 975     





Gly Val Met Ala Leu Gln Arg Lys Leu Thr Gly Met Glu Arg Asp Leu 

            980                 985                 990         





Val Ala Ile Glu Ala Lys Leu Ser  Asp Leu Gln Lys Glu  Ala Glu Lys 

        995                 1000                 1005             





Leu Glu  Ser Glu His Pro Asp  Gln Ala Gln Ala Ile  Leu Ser Arg 

    1010                 1015                 1020             





Leu Ala  Glu Ile Ser Asp Val  Trp Glu Glu Met Lys  Thr Thr Leu 

    1025                 1030                 1035             





Lys Asn  Arg Glu Ala Ser Leu  Gly Glu Ala Ser Lys  Leu Gln Gln 

    1040                 1045                 1050             





Phe Leu  Arg Asp Leu Asp Asp  Phe Gln Ser Trp Leu  Ser Arg Thr 

    1055                 1060                 1065             





Gln Thr  Ala Ile Ala Ser Glu  Asp Met Pro Asn Thr  Leu Thr Glu 

    1070                 1075                 1080             





Ala Glu  Lys Leu Leu Thr Gln  His Glu Asn Ile Lys  Asn Glu Ile 

    1085                 1090                 1095             





Asp Asn  Tyr Glu Glu Asp Tyr  Gln Lys Met Arg Asp  Met Gly Glu 

    1100                 1105                 1110             





Met Val  Thr Gln Gly Gln Thr  Asp Ala Gln Tyr Met  Phe Leu Arg 

    1115                 1120                 1125             





Gln Arg  Leu Gln Ala Leu Asp  Thr Gly Trp Asn Glu  Leu His Lys 

    1130                 1135                 1140             





Met Trp  Glu Asn Arg Gln Asn  Leu Leu Ser Gln Ser  His Ala Tyr 

    1145                 1150                 1155             





Gln Gln  Phe Leu Arg Asp Thr  Lys Gln Ala Glu Ala  Phe Leu Asn 

    1160                 1165                 1170             





Asn Gln  Glu Tyr Val Leu Ala  His Thr Glu Met Pro  Thr Thr Leu 

    1175                 1180                 1185             





Glu Gly  Ala Glu Ala Ala Ile  Lys Lys Gln Glu Asp  Phe Met Thr 

    1190                 1195                 1200             





Thr Met  Asp Ala Asn Glu Glu  Lys Ile Asn Ala Val  Val Glu Thr 

    1205                 1210                 1215             





Gly Arg  Arg Leu Val Ser Asp  Gly Asn Ile Asn Ser  Asp Arg Ile 

    1220                 1225                 1230             





Gln Glu  Lys Val Asp Ser Ile  Asp Asp Arg His Arg  Lys Asn Arg 

    1235                 1240                 1245             





Glu Thr  Ala Ser Glu Leu Leu  Met Arg Leu Lys Asp  Asn Arg Asp 

    1250                 1255                 1260             





Leu Gln  Lys Phe Leu Gln Asp  Cys Gln Glu Leu Ser  Leu Trp Ile 

    1265                 1270                 1275             





Asn Glu  Lys Met Leu Thr Ala  Gln Asp Met Ser Tyr  Asp Glu Ala 

    1280                 1285                 1290             





Arg Asn  Leu His Ser Lys Trp  Leu Lys His Gln Ala  Phe Met Ala 

    1295                 1300                 1305             





Glu Leu  Ala Ser Asn Lys Glu  Trp Leu Asp Lys Ile  Glu Lys Glu 

    1310                 1315                 1320             





Gly Met  Gln Leu Ile Ser Glu  Lys Pro Glu Thr Glu  Ala Val Val 

    1325                 1330                 1335             





Lys Glu  Lys Leu Thr Gly Leu  His Lys Met Trp Glu  Val Leu Glu 

    1340                 1345                 1350             





Ser Thr  Thr Gln Thr Lys Ala  Gln Arg Leu Phe Asp  Ala Asn Lys 

    1355                 1360                 1365             





Ala Glu  Leu Phe Thr Gln Ser  Cys Ala Asp Leu Asp  Lys Trp Leu 

    1370                 1375                 1380             





His Gly  Leu Glu Ser Gln Ile  Gln Ser Asp Asp Tyr  Gly Lys Asp 

    1385                 1390                 1395             





Leu Thr  Ser Val Asn Ile Leu  Leu Lys Lys Gln Gln  Met Leu Glu 

    1400                 1405                 1410             





Asn Gln  Met Glu Val Arg Lys  Lys Glu Ile Glu Glu  Leu Gln Ser 

    1415                 1420                 1425             





Gln Ala  Gln Ala Leu Ser Gln  Glu Gly Lys Ser Thr  Asp Glu Val 

    1430                 1435                 1440             





Asp Ser  Lys Arg Leu Thr Val  Gln Thr Lys Phe Met  Glu Leu Leu 

    1445                 1450                 1455             





Glu Pro  Leu Asn Glu Arg Lys  His Asn Leu Leu Ala  Ser Lys Glu 

    1460                 1465                 1470             





Ile His  Gln Phe Asn Arg Asp  Val Glu Asp Glu Ile  Leu Trp Val 

    1475                 1480                 1485             





Gly Glu  Arg Met Pro Leu Ala  Thr Ser Thr Asp His  Gly His Asn 

    1490                 1495                 1500             





Leu Gln  Thr Val Gln Leu Leu  Ile Lys Lys Asn Gln  Thr Leu Gln 

    1505                 1510                 1515             





Lys Glu  Ile Gln Gly His Gln  Pro Arg Ile Asp Asp  Ile Phe Glu 

    1520                 1525                 1530             





Arg Ser  Gln Asn Ile Val Thr  Asp Ser Ser Ser Leu  Ser Ala Glu 

    1535                 1540                 1545             





Ala Ile  Arg Gln Arg Leu Ala  Asp Leu Lys Gln Leu  Trp Gly Leu 

    1550                 1555                 1560             





Leu Ile  Glu Glu Thr Glu Lys  Arg His Arg Arg Leu  Glu Glu Ala 

    1565                 1570                 1575             





His Arg  Ala Gln Gln Tyr Tyr  Phe Asp Ala Ala Glu  Ala Glu Ala 

    1580                 1585                 1590             





Trp Met  Ser Glu Gln Glu Leu  Tyr Met Met Ser Glu  Glu Lys Ala 

    1595                 1600                 1605             





Lys Asp  Glu Gln Ser Ala Val  Ser Met Leu Lys Lys  His Gln Ile 

    1610                 1615                 1620             





Leu Glu  Gln Ala Val Glu Asp  Tyr Ala Glu Thr Val  His Gln Leu 

    1625                 1630                 1635             





Ser Lys  Thr Ser Arg Ala Leu  Val Ala Asp Ser His  Pro Glu Ser 

    1640                 1645                 1650             





Glu Arg  Ile Ser Met Arg Gln  Ser Lys Val Asp Lys  Leu Tyr Ala 

    1655                 1660                 1665             





Gly Leu  Lys Asp Leu Ala Glu  Glu Arg Arg Gly Lys  Leu Asp Glu 

    1670                 1675                 1680             





Arg His  Arg Leu Phe Gln Leu  Asn Arg Glu Val Asp  Asp Leu Glu 

    1685                 1690                 1695             





Gln Trp  Ile Ala Glu Arg Glu  Val Val Ala Gly Ser  His Glu Leu 

    1700                 1705                 1710             





Gly Gln  Asp Tyr Glu His Val  Thr Met Leu Gln Glu  Arg Phe Arg 

    1715                 1720                 1725             





Glu Phe  Ala Arg Asp Thr Gly  Asn Ile Gly Gln Glu  Arg Val Asp 

    1730                 1735                 1740             





Thr Val  Asn His Leu Ala Asp  Glu Leu Ile Asn Ser  Gly His Ser 

    1745                 1750                 1755             





Asp Ala  Ala Thr Ile Ala Glu  Trp Lys Asp Gly Leu  Asn Glu Ala 

    1760                 1765                 1770             





Trp Ala  Asp Leu Leu Glu Leu  Ile Asp Thr Arg Thr  Gln Ile Leu 

    1775                 1780                 1785             





Ala Ala  Ser Tyr Glu Leu His  Lys Phe Tyr His Asp  Ala Lys Glu 

    1790                 1795                 1800             





Ile Phe  Gly Arg Ile Gln Asp  Lys His Lys Lys Leu  Pro Glu Glu 

    1805                 1810                 1815             





Leu Gly  Arg Asp Gln Asn Thr  Val Glu Thr Leu Gln  Arg Met His 

    1820                 1825                 1830             





Thr Thr  Phe Glu His Asp Ile  Gln Ala Leu Gly Thr  Gln Val Arg 

    1835                 1840                 1845             





Gln Leu  Gln Glu Asp Ala Ala  Arg Leu Gln Ala Ala  Tyr Ala Gly 

    1850                 1855                 1860             





Asp Lys  Ala Asp Asp Ile Gln  Lys Arg Glu Asn Glu  Val Leu Glu 

    1865                 1870                 1875             





Ala Trp  Lys Ser Leu Leu Asp  Ala Cys Glu Ser Arg  Arg Val Arg 

    1880                 1885                 1890             





Leu Val  Asp Thr Gly Asp Lys  Phe Arg Phe Phe Ser  Met Val Arg 

    1895                 1900                 1905             





Asp Leu  Met Leu Trp Met Glu  Asp Val Ile Arg Gln  Ile Glu Ala 

    1910                 1915                 1920             





Gln Glu  Lys Pro Arg Asp Val  Ser Ser Val Glu Leu  Leu Met Asn 

    1925                 1930                 1935             





Asn His  Gln Gly Ile Lys Ala  Glu Ile Asp Ala Arg  Asn Asp Ser 

    1940                 1945                 1950             





Phe Thr  Thr Cys Ile Glu Leu  Gly Lys Ser Leu Leu  Ala Arg Lys 

    1955                 1960                 1965             





His Tyr  Ala Ser Glu Glu Ile  Lys Glu Lys Leu Leu  Gln Leu Thr 

    1970                 1975                 1980             





Glu Lys  Arg Lys Glu Met Ile  Asp Lys Trp Glu Asp  Arg Trp Glu 

    1985                 1990                 1995             





Trp Leu  Arg Leu Ile Leu Glu  Val His Gln Phe Ser  Arg Asp Ala 

    2000                 2005                 2010             





Ser Val  Ala Glu Ala Trp Leu  Leu Gly Gln Glu Pro  Tyr Leu Ser 

    2015                 2020                 2025             





Ser Arg  Glu Ile Gly Gln Ser  Val Asp Glu Val Glu  Lys Leu Ile 

    2030                 2035                 2040             





Lys Arg  His Glu Ala Phe Glu  Lys Ser Ala Ala Thr  Trp Asp Glu 

    2045                 2050                 2055             





Arg Phe  Ser Ala Leu Glu Arg  Leu Thr Thr Leu Glu  Leu Leu Glu 

    2060                 2065                 2070             





Val Arg  Arg Gln Gln Glu Glu  Glu Glu Arg Lys Arg  Arg Pro Pro 

    2075                 2080                 2085             





Ser Pro  Glu Pro Ser Thr Lys  Val Ser Glu Glu Ala  Glu Ser Gln 

    2090                 2095                 2100             





Gln Gln  Trp Asp Thr Ser Lys  Gly Glu Gln Val Ser  Gln Asn Gly 

    2105                 2110                 2115             





Leu Pro  Ala Glu Gln Gly Ser  Pro Arg Val Ser Tyr  Arg Ser Gln 

    2120                 2125                 2130             





Thr Tyr  Gln Asn Tyr Lys Asn  Phe Asn Ser Arg Arg  Thr Ala Ser 

    2135                 2140                 2145             





Asp Gln  Pro Trp Ser Gly Leu  

    2150                 2155 





<210>  308

<211>  1646

<212>  DNA

<213>  Homo sapiens



<400>  308

gccaagcccc gcccctcagg ccggggcgcg accgcggatc cgcagttccc gggccagcct       60



ggggcggccg gccaggaacc acccgttaag gtgtcttctc tttagggatg gtgaggttgg      120



aaaaaggctc ctgtaaccct cctccaggat gaaccacctg ccagaagaca tggagaacgc      180



tctcaccggg agccagagct cccatgcttc tctgcgcaat atccattcca tcaaccccac      240



acaactcatg gccaggattg agtcctatga aggaagggaa aagaaaggca tatctgatgt      300



caggaggact ttctgtttgt ttgtcacctt tgacctctta ttcgtaacat tactgtggat      360



aatagagtta aatgtgaatg gaggcattga gaacacatta gagaaggagg tgatgcagta      420



tgactactat tcttcatatt ttgatatatt tcttctggca gtttttcgat ttaaagtgtt      480



aatacttgca tatgctgtgt gcagactgcg ccattggtgg gcaatagcgt tgacaacggc      540



agtgaccagt gcctttttac tagcaaaagt gatcctttcg aagcttttct ctcaaggggc      600



ttttggctat gtgctgccca tcatttcatt catccttgcc tggattgaga cgtggttcct      660



ggatttcaaa gtgttacctc aagaagcaga agaagaaaac agactcctga tagttcagga      720



tgcttcagag agggcagcac ttatacctgg tggtctttct gatggtcagt tttattcccc      780



tcctgaatcc gaagcaggat ctgaagaagc tgaagaaaaa caggacagtg agaaaccact      840



tttagaacta tgagtactac ttttgttaaa tgtgaaaaac cctcacagaa agtcatcgag      900



gcaaaaagag gcaggcagtg gagtctccct gtcgacagta aagttgaaat ggtgacgtcc      960



actgctggct ttattgaaca gctaataaag atttatttat tgtaatacct cacagacgtt     1020



gtaccatatc catgcacatt tagttgcctg cctgtggctg gtaaggtaat gtcatgattc     1080



atcctctctt cagtgagact gagcctgatg tgttaacaaa taggtgaaga aagtcttgtg     1140



ctgtattcct aatcaaaaga cttaatatat tgaagtaaca cttttttagt aagcaagata     1200



cctttttatt tcaattcaca gaatggaatt tttttgtttc atgtctcaga tttattttgt     1260



atttcttttt taacactcta catttccctt gttttttaac tcatgcacat gtgctctttg     1320



tacagtttta aaaagtgtaa taaaatctga catgtcaatg tggctagttt tatttttctt     1380



gttttgcatt atgtgtatgg cctgaagtgt tggacttgca aaaggggaag aaaggaattg     1440



cgaatacatg taaaatgtca ccagacattt gtattatttt tatcatgaaa tcatgttttt     1500



ctctgattgt tctgaaatgt tctaaatact cttattttga atgcacaaaa tgacttaaac     1560



cattcatatc atgtttcctt tgcgttcagc caatttcaat taaaatgaac taaattaaaa     1620



aaaaaaaaaa aaaaaaaaaa aaaaaa                                          1646





<210>  309

<211>  234

<212>  PRT

<213>  Homo sapiens



<400>  309



Met Asn His Leu Pro Glu Asp Met Glu Asn Ala Leu Thr Gly Ser Gln 

1               5                   10                  15      





Ser Ser His Ala Ser Leu Arg Asn Ile His Ser Ile Asn Pro Thr Gln 

            20                  25                  30          





Leu Met Ala Arg Ile Glu Ser Tyr Glu Gly Arg Glu Lys Lys Gly Ile 

        35                  40                  45              





Ser Asp Val Arg Arg Thr Phe Cys Leu Phe Val Thr Phe Asp Leu Leu 

    50                  55                  60                  





Phe Val Thr Leu Leu Trp Ile Ile Glu Leu Asn Val Asn Gly Gly Ile 

65                  70                  75                  80  





Glu Asn Thr Leu Glu Lys Glu Val Met Gln Tyr Asp Tyr Tyr Ser Ser 

                85                  90                  95      





Tyr Phe Asp Ile Phe Leu Leu Ala Val Phe Arg Phe Lys Val Leu Ile 

            100                 105                 110         





Leu Ala Tyr Ala Val Cys Arg Leu Arg His Trp Trp Ala Ile Ala Leu 

        115                 120                 125             





Thr Thr Ala Val Thr Ser Ala Phe Leu Leu Ala Lys Val Ile Leu Ser 

    130                 135                 140                 





Lys Leu Phe Ser Gln Gly Ala Phe Gly Tyr Val Leu Pro Ile Ile Ser 

145                 150                 155                 160 





Phe Ile Leu Ala Trp Ile Glu Thr Trp Phe Leu Asp Phe Lys Val Leu 

                165                 170                 175     





Pro Gln Glu Ala Glu Glu Glu Asn Arg Leu Leu Ile Val Gln Asp Ala 

            180                 185                 190         





Ser Glu Arg Ala Ala Leu Ile Pro Gly Gly Leu Ser Asp Gly Gln Phe 

        195                 200                 205             





Tyr Ser Pro Pro Glu Ser Glu Ala Gly Ser Glu Glu Ala Glu Glu Lys 

    210                 215                 220                 





Gln Asp Ser Glu Lys Pro Leu Leu Glu Leu 

225                 230                 





<210>  310

<211>  1313

<212>  DNA

<213>  Homo sapiens



<400>  310

catttgttgc atttccagtt tccaatacca actcacctac aaagatttta ccaaaaacct       60



taggaccaat aaatgtgaat gttggacccc aaatgattat aagcacacca cagagactaa      120



ccagttcagg aagtgttctg attgggagtc catatacccc tgcaccagca atggttactc      180



agacacacat agcagaagct actggctggg tccctggtga tagaaaacgg gctagaaaat      240



ttatagactc tgatttttca gaaagtaaac gaagcaaaaa aggagataaa aatgggaaag      300



gcttgagaca cttttcaatg aaagtgtgtg agaaagttca acgaaaaggt acaacatcgt      360



acaatgaagt cgctgatgag ctggtgtcag agttcaccaa ttcaaataac catttggctg      420



ctgattcgca ggcttatgat cagaagaaca ttaggcgaag agtttatgat gctttaaatg      480



tgctaatggc aatgaacata atttcaaagg aaaaaaaaga aatcaagtgg attggcctgc      540



ctaccaattc tgctcaggaa tgtcagaatc tggagataga gaagcagagg cggatagaac      600



ggataaagca gaagcgggcc cagctgcaag aacttctcct acagcaaatc gctttcaaaa      660



acctggtaca gagaaatcga caaaatgagc agcaaaacca gggcccgccg gctctgaact      720



ctaccattca gctgccattc ataatcatca atacaagcag aaaaacagtc atagattgca      780



gcatctccag tgacaagttt gagtatcttt tcaattttga caacaccttt gagatccatg      840



atgacataga agtactaaag cggatgggaa tgtcgtttgg cctggagtca ggcaaatgct      900



ctctggagga tctgaaactt gcgaaatccc tggtgccaaa ggctttagaa ggttatatca      960



cagatatctc cacaggacct tcttggttaa atcagggact acttctgaac tctacccaat     1020



cagtttcaaa tttagacctg accactggtg ccaccttacc ccagtcaagt gtaaaccaag     1080



ggttatgctt ggatgcagaa gtggccttag caactgggca gttcctggcc ccaaacagtc     1140



accagtccag cagtgcggcc tctcactgct ccgagtcccg aggcgagacc ccctgttcgt     1200



tcaatgatga agatgaggaa gatgatgagg aggattcctc ctccccagaa taaagacaag     1260



agaaagccta cgtttcaata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            1313





<210>  311

<211>  386

<212>  PRT

<213>  Homo sapiens



<400>  311



Met Ile Ile Ser Thr Pro Gln Arg Leu Thr Ser Ser Gly Ser Val Leu 

1               5                   10                  15      





Ile Gly Ser Pro Tyr Thr Pro Ala Pro Ala Met Val Thr Gln Thr His 

            20                  25                  30          





Ile Ala Glu Ala Thr Gly Trp Val Pro Gly Asp Arg Lys Arg Ala Arg 

        35                  40                  45              





Lys Phe Ile Asp Ser Asp Phe Ser Glu Ser Lys Arg Ser Lys Lys Gly 

    50                  55                  60                  





Asp Lys Asn Gly Lys Gly Leu Arg His Phe Ser Met Lys Val Cys Glu 

65                  70                  75                  80  





Lys Val Gln Arg Lys Gly Thr Thr Ser Tyr Asn Glu Val Ala Asp Glu 

                85                  90                  95      





Leu Val Ser Glu Phe Thr Asn Ser Asn Asn His Leu Ala Ala Asp Ser 

            100                 105                 110         





Gln Ala Tyr Asp Gln Lys Asn Ile Arg Arg Arg Val Tyr Asp Ala Leu 

        115                 120                 125             





Asn Val Leu Met Ala Met Asn Ile Ile Ser Lys Glu Lys Lys Glu Ile 

    130                 135                 140                 





Lys Trp Ile Gly Leu Pro Thr Asn Ser Ala Gln Glu Cys Gln Asn Leu 

145                 150                 155                 160 





Glu Ile Glu Lys Gln Arg Arg Ile Glu Arg Ile Lys Gln Lys Arg Ala 

                165                 170                 175     





Gln Leu Gln Glu Leu Leu Leu Gln Gln Ile Ala Phe Lys Asn Leu Val 

            180                 185                 190         





Gln Arg Asn Arg Gln Asn Glu Gln Gln Asn Gln Gly Pro Pro Ala Leu 

        195                 200                 205             





Asn Ser Thr Ile Gln Leu Pro Phe Ile Ile Ile Asn Thr Ser Arg Lys 

    210                 215                 220                 





Thr Val Ile Asp Cys Ser Ile Ser Ser Asp Lys Phe Glu Tyr Leu Phe 

225                 230                 235                 240 





Asn Phe Asp Asn Thr Phe Glu Ile His Asp Asp Ile Glu Val Leu Lys 

                245                 250                 255     





Arg Met Gly Met Ser Phe Gly Leu Glu Ser Gly Lys Cys Ser Leu Glu 

            260                 265                 270         





Asp Leu Lys Leu Ala Lys Ser Leu Val Pro Lys Ala Leu Glu Gly Tyr 

        275                 280                 285             





Ile Thr Asp Ile Ser Thr Gly Pro Ser Trp Leu Asn Gln Gly Leu Leu 

    290                 295                 300                 





Leu Asn Ser Thr Gln Ser Val Ser Asn Leu Asp Leu Thr Thr Gly Ala 

305                 310                 315                 320 





Thr Leu Pro Gln Ser Ser Val Asn Gln Gly Leu Cys Leu Asp Ala Glu 

                325                 330                 335     





Val Ala Leu Ala Thr Gly Gln Phe Leu Ala Pro Asn Ser His Gln Ser 

            340                 345                 350         





Ser Ser Ala Ala Ser His Cys Ser Glu Ser Arg Gly Glu Thr Pro Cys 

        355                 360                 365             





Ser Phe Asn Asp Glu Asp Glu Glu Asp Asp Glu Glu Asp Ser Ser Ser 

    370                 375                 380                 





Pro Glu 

385     





<210>  312

<211>  5625

<212>  DNA

<213>  Homo sapiens



<400>  312

acatccgggc ttctgctact agtgagagga agatggcggc cgcggctgtg gtggttcccg       60



cagagtggat aaagaactgg gagaaatcag ggagaggcga atttttgcat ttatgtcgga      120



tcctcagtga aaataaaagc catgatagtt caacatacag agatttccag caagctctct      180



atgagttgtc atatcatgta attaaaggaa atctaaagca tgaacaggca tctaatgttc      240



ttagtgacat tagtgaattt cgtgaggata tgccctccat tcttgctgat gtattctgca      300



tattagacat tgagacaaat tgtttagaag aaaaaagcaa gagagactat tttacacagt      360



tggtattagc atgtttgtat ttagtttcag acacagttct aaaggaacgc ctggatccag      420



aaacactgga atcattaggg cttatcaaac aatcacagca attcaatcaa aagtcagtta      480



aaatcaagac aaaactcttt tataagcagc aaaaattcaa tttgttaaga gaagagaatg      540



aaggttatgc caagctgatt gctgaattgg ggcaagattt atctggaagt attactagtg      600



atttaatctt agaaaatatc aaatctttaa taggatgctt taatctggat cccaatagag      660



ttttggatgt cattttagaa gtgtttgaat gcaggccaga acacgatgac ttctttatat      720



ctttgttaga atcttacatg agtatgtgtg aaccgcaaac actgtgtcat attcttgggt      780



tcaaattcaa gttttaccag gaaccaaatg gcgagacacc atcatcttta tacagagttg      840



cagcagtact tctacaattt aatcttattg atttagatga tctttatgta catcttcttc      900



cggctgataa ttgcattatg gatgaacaca aacgagaaat tgcggaagct aagcaaattg      960



ttagaaagct tacgatggtt gtgttgtctt ctgaaaaaat ggatgagcga gagaaagaaa     1020



aggaaaaaga agaggagaaa gtagagaaac cacctgataa ccaaaaactt ggcttgttgg     1080



aagccttatt aaagattggt gattggcaac atgcacagaa cattatggat cagatgcctc     1140



catactatgc agcttcacac aagctaatag cccttgctat ttgcaagctc attcatataa     1200



ctattgagcc tctctaccga agagttggag ttcctaaagg tgctaaaggc tcacctgtta     1260



atgctttgca aaacaagaga gcaccaaaac aagctgagag ctttgaagat ttgaggagag     1320



acgtgttcaa tatgttctgt taccttggtc ctcacctttc tcacgatccc attttatttg     1380



caaaagtggt gcgcataggc aagtcattta tgaaggagtt tcagtctgat ggaagcaaac     1440



aagaagataa agaaaaaacg gaagttatcc ttagctgttt gcttagcatt actgaccagg     1500



tactacttcc atctctttct ttgatggact gcaatgcttg tatgtctgag gaactatggg     1560



gaatgtttaa aacatttcca tatcagcata gatatcgtct gtatggccag tggaagaatg     1620



aaacttataa cagtcaccca cttttagtaa aagttaaagc tcaaacaata gacagagcca     1680



aatatatcat gaagcgccta accaaggaaa atgtgaagcc ttctggaaga caaattggga     1740



agttgagcca cagcaatcca accattttgt ttgattatat cttgtcacaa atacagaagt     1800



atgataactt aataacacct gtagtagatt cattgaaata cctcacttca ctgaattatg     1860



atgtcttggc ctattgtatc attgaagctt tagctaatcc agaaaaggaa agaatgaaac     1920



atgatgacac aaccatctca agctggcttc agagtctggc tagtttctgt ggtgcagttt     1980



ttcgtaaata tccaattgat cttgctggtc ttcttcagta tgttgccaat cagctaaagg     2040



cgggcaaaag ttttgacctg cttatattga aagaagtggt acaaaaaatg gcaggaatag     2100



aaattacaga ggaaatgaca atggagcaac tagaggctat gactggtgga gagcagctaa     2160



aagctgaggg tggttatttt ggtcagatca gaaacactaa aaaatcctct cagagattaa     2220



aggatgctct attggaccat gatcttgccc ttcctctctg tctgcttatg gctcagcaga     2280



gaaatggggt aatctttcag gaaggtggag agaaacattt gaaacttgtg ggaaagctct     2340



atgaccagtg tcatgatacc ctggtgcagt ttggtgggtt tttagcatct aatctgagca     2400



cagaagatta tataaagcga gtgccttcaa ttgatgtact ctgtaatgaa tttcatacac     2460



cccatgatgc agcatttttc ctgtctaggc caatgtatgc ccatcatatt tcgtcaaagt     2520



atgatgaact taaaaaatca gaaaagggaa gtaaacagca acataaagtt cataagtaca     2580



ttacatcatg tgagatggtg atggcgcctg tccatgaagc agtggtctcc ttacatgttt     2640



ccaaagtctg ggatgacatc agccctcaat tctatgctac attctggtca ttgacaatgt     2700



atgaccttgc agttccacac accagctatg aacgagaagt caataaactt aaagtccaga     2760



tgaaagcaat tgatgacaat caggaaatgc ccccaaataa aaagaaaaaa gagaaggagc     2820



gctgtactgc ccttcaggac aagcttcttg aagaagaaaa gaaacagatg gaacatgtac     2880



agagagttct acagagattg aaactggaaa aggacaactg gcttttagca aaatctacca     2940



aaaatgagac catcacaaaa tttctacagc tgtgtatatt tcctcgatgt attttttcag     3000



caattgatgc tgtttactgt gctcgttttg ttgaattggt acatcaacag aaaactccaa     3060



atttttccac acttctttgc tatgatcgag ttttctctga cataatttac acagttgcaa     3120



gctgtactga aaatgaagcc agtcgatacg gaaggtttct ttgctgcatg ttagagactg     3180



tgaccaggtg gcatagtgat agagccacat atgaaaagga atgtggaaac tatccaggat     3240



tccttaccat attacgggca actggatttg atggtggaaa taaggctgat caattagact     3300



atgaaaattt tcgacatgtt gtacataaat ggcattacaa actaaccaag gcatcggtac     3360



attgccttga aacaggcgaa tatactcaca tcaggaatat cttgattgtg ctaacaaaaa     3420



tacttccttg gtacccaaaa gttttgaatc tgggtcaagc tttggaaaga agagtacaca     3480



aaatctgcca agaagaaaaa gagaagaggc cagatctata tgcattggct atgggctact     3540



ctgggcagtt gaaaagtaga aagtcataca tgatacctga aaatgagttt catcacaaag     3600



acccccctcc gaggaatgca gttgccagtg tgcaaaatgg gcctggtggt gggccttctt     3660



catcatcaat aggaagtgca tctaaatcgg atgaaagcag tactgaggag actgataaat     3720



caagggagag atctcagtgt ggtgtgaaag ctgttaataa agcttctagt accacaccta     3780



aagggaattc aagcaatgga aatagtggct ctaacagcaa caaagctgtt aaagaaaatg     3840



acaaagaaaa agggaaagag aaagaaaaag agaaaaaaga aaagactcca gctactactc     3900



cagaggccag ggtacttggt aaagatggta aagaaaaacc aaaggaagag cggccaaata     3960



aagatgaaaa agcaagagag accaaggaaa gaacgccgaa gtctgacaaa gagaaagaaa     4020



aattcaagaa ggaagaaaaa gctaaagatg agaaatttaa gaccactgtc cccaacgcag     4080



aatcaaaatc aactcaagaa agggaaagag agaaggagcc atccagagaa agagatatag     4140



caaaggaaat gaaatcaaag gaaaatgtta aaggaggaga aaaaacacca gtttctgggt     4200



ccttgaaatc acctgttccc agatcagata ttccagagcc tgaaagggaa caaaaacgcc     4260



gcaaaattga tactcaccct tctccatcac attcctccac agtaaaggac agtctcatcg     4320



aactcaagga atcttcagca aagctctaca ttaatcatac tcctccacca ctgtccaaga     4380



gtaaggagag agaaatggac aagaaagatt tggacaagtc aagggaaaga tccagagaaa     4440



gagagaaaaa agatgaaaag gacaggaaag agcggaaaag ggatcactca aacaacgacc     4500



gtgaagtgcc accggactta accaagagac gtaaagagga gaatggaaca atgggggttt     4560



caaaacataa aagtgaaagt ccttgtgaat ctccttatcc aaatgagaaa gacaaggaaa     4620



aaaataagtc aaaatcttca ggcaaagaaa aaggcagtga ttcatttaaa tctgagaaga     4680



tggataaaat ctcctccggt ggcaaaaagg agtccaggca tgataaagaa aagatagaaa     4740



agaaagagaa acgggacagt tcaggaggaa aggaagagaa gaaacatcat aagtcctcgg     4800



acaagcacag ataatgaaga ctttccatca aggtgagatc ggactggaac tgttcggctg     4860



cgaccagaaa tttattttcc tgagtaaatt gccgagaatt aagaatgaag agggccattt     4920



gcatctcctt aaattattca gttacctgct ttattgctcc atgtggaaaa cttaaaattg     4980



ttaagttgtg cattactgta ttttaacttg ttgcttagtt tctacatgtt tattttcagt     5040



aatggctgaa agtgttaact gttccatact tttagcacaa tgtgctgcat aaggttacct     5100



gtgtacagag ttttacttta gattaactaa atattgcctg ggttcagttt ttatttccat     5160



tctgaaatgc ttccttttta ttgtttgaaa ctgaaaataa acaattgttg aacccttttg     5220



attttacctc attttaaaac tgttttaatt tattatttgg cttgttctta atattagtca     5280



ctaaaagcag tgggagcatt gtcttatgaa atgcttagga atcattttat atagtacatg     5340



tacaacatta aacgtgttta aaaaagaaaa aggtaccagc gatcacttgt cccttgccat     5400



tttttcttgt aattatgtta gacaaatctt ggcggcgggg ggatcaaaac ataattgttt     5460



taattctaca gctgtaggag ctttgtattg ctgaactttc atctggaaaa gtttcacagt     5520



gacattttta aaagagaatt tttttatctg ccgaattcta ccagtgtaac cttttttcta     5580



aataaacaat agttttctca aatggttgta aaaaaaaaaa aaaaa                     5625





<210>  313

<211>  1593

<212>  PRT

<213>  Homo sapiens



<400>  313



Met Ala Ala Ala Ala Val Val Val Pro Ala Glu Trp Ile Lys Asn Trp 

1               5                   10                  15      





Glu Lys Ser Gly Arg Gly Glu Phe Leu His Leu Cys Arg Ile Leu Ser 

            20                  25                  30          





Glu Asn Lys Ser His Asp Ser Ser Thr Tyr Arg Asp Phe Gln Gln Ala 

        35                  40                  45              





Leu Tyr Glu Leu Ser Tyr His Val Ile Lys Gly Asn Leu Lys His Glu 

    50                  55                  60                  





Gln Ala Ser Asn Val Leu Ser Asp Ile Ser Glu Phe Arg Glu Asp Met 

65                  70                  75                  80  





Pro Ser Ile Leu Ala Asp Val Phe Cys Ile Leu Asp Ile Glu Thr Asn 

                85                  90                  95      





Cys Leu Glu Glu Lys Ser Lys Arg Asp Tyr Phe Thr Gln Leu Val Leu 

            100                 105                 110         





Ala Cys Leu Tyr Leu Val Ser Asp Thr Val Leu Lys Glu Arg Leu Asp 

        115                 120                 125             





Pro Glu Thr Leu Glu Ser Leu Gly Leu Ile Lys Gln Ser Gln Gln Phe 

    130                 135                 140                 





Asn Gln Lys Ser Val Lys Ile Lys Thr Lys Leu Phe Tyr Lys Gln Gln 

145                 150                 155                 160 





Lys Phe Asn Leu Leu Arg Glu Glu Asn Glu Gly Tyr Ala Lys Leu Ile 

                165                 170                 175     





Ala Glu Leu Gly Gln Asp Leu Ser Gly Ser Ile Thr Ser Asp Leu Ile 

            180                 185                 190         





Leu Glu Asn Ile Lys Ser Leu Ile Gly Cys Phe Asn Leu Asp Pro Asn 

        195                 200                 205             





Arg Val Leu Asp Val Ile Leu Glu Val Phe Glu Cys Arg Pro Glu His 

    210                 215                 220                 





Asp Asp Phe Phe Ile Ser Leu Leu Glu Ser Tyr Met Ser Met Cys Glu 

225                 230                 235                 240 





Pro Gln Thr Leu Cys His Ile Leu Gly Phe Lys Phe Lys Phe Tyr Gln 

                245                 250                 255     





Glu Pro Asn Gly Glu Thr Pro Ser Ser Leu Tyr Arg Val Ala Ala Val 

            260                 265                 270         





Leu Leu Gln Phe Asn Leu Ile Asp Leu Asp Asp Leu Tyr Val His Leu 

        275                 280                 285             





Leu Pro Ala Asp Asn Cys Ile Met Asp Glu His Lys Arg Glu Ile Ala 

    290                 295                 300                 





Glu Ala Lys Gln Ile Val Arg Lys Leu Thr Met Val Val Leu Ser Ser 

305                 310                 315                 320 





Glu Lys Met Asp Glu Arg Glu Lys Glu Lys Glu Lys Glu Glu Glu Lys 

                325                 330                 335     





Val Glu Lys Pro Pro Asp Asn Gln Lys Leu Gly Leu Leu Glu Ala Leu 

            340                 345                 350         





Leu Lys Ile Gly Asp Trp Gln His Ala Gln Asn Ile Met Asp Gln Met 

        355                 360                 365             





Pro Pro Tyr Tyr Ala Ala Ser His Lys Leu Ile Ala Leu Ala Ile Cys 

    370                 375                 380                 





Lys Leu Ile His Ile Thr Ile Glu Pro Leu Tyr Arg Arg Val Gly Val 

385                 390                 395                 400 





Pro Lys Gly Ala Lys Gly Ser Pro Val Asn Ala Leu Gln Asn Lys Arg 

                405                 410                 415     





Ala Pro Lys Gln Ala Glu Ser Phe Glu Asp Leu Arg Arg Asp Val Phe 

            420                 425                 430         





Asn Met Phe Cys Tyr Leu Gly Pro His Leu Ser His Asp Pro Ile Leu 

        435                 440                 445             





Phe Ala Lys Val Val Arg Ile Gly Lys Ser Phe Met Lys Glu Phe Gln 

    450                 455                 460                 





Ser Asp Gly Ser Lys Gln Glu Asp Lys Glu Lys Thr Glu Val Ile Leu 

465                 470                 475                 480 





Ser Cys Leu Leu Ser Ile Thr Asp Gln Val Leu Leu Pro Ser Leu Ser 

                485                 490                 495     





Leu Met Asp Cys Asn Ala Cys Met Ser Glu Glu Leu Trp Gly Met Phe 

            500                 505                 510         





Lys Thr Phe Pro Tyr Gln His Arg Tyr Arg Leu Tyr Gly Gln Trp Lys 

        515                 520                 525             





Asn Glu Thr Tyr Asn Ser His Pro Leu Leu Val Lys Val Lys Ala Gln 

    530                 535                 540                 





Thr Ile Asp Arg Ala Lys Tyr Ile Met Lys Arg Leu Thr Lys Glu Asn 

545                 550                 555                 560 





Val Lys Pro Ser Gly Arg Gln Ile Gly Lys Leu Ser His Ser Asn Pro 

                565                 570                 575     





Thr Ile Leu Phe Asp Tyr Ile Leu Ser Gln Ile Gln Lys Tyr Asp Asn 

            580                 585                 590         





Leu Ile Thr Pro Val Val Asp Ser Leu Lys Tyr Leu Thr Ser Leu Asn 

        595                 600                 605             





Tyr Asp Val Leu Ala Tyr Cys Ile Ile Glu Ala Leu Ala Asn Pro Glu 

    610                 615                 620                 





Lys Glu Arg Met Lys His Asp Asp Thr Thr Ile Ser Ser Trp Leu Gln 

625                 630                 635                 640 





Ser Leu Ala Ser Phe Cys Gly Ala Val Phe Arg Lys Tyr Pro Ile Asp 

                645                 650                 655     





Leu Ala Gly Leu Leu Gln Tyr Val Ala Asn Gln Leu Lys Ala Gly Lys 

            660                 665                 670         





Ser Phe Asp Leu Leu Ile Leu Lys Glu Val Val Gln Lys Met Ala Gly 

        675                 680                 685             





Ile Glu Ile Thr Glu Glu Met Thr Met Glu Gln Leu Glu Ala Met Thr 

    690                 695                 700                 





Gly Gly Glu Gln Leu Lys Ala Glu Gly Gly Tyr Phe Gly Gln Ile Arg 

705                 710                 715                 720 





Asn Thr Lys Lys Ser Ser Gln Arg Leu Lys Asp Ala Leu Leu Asp His 

                725                 730                 735     





Asp Leu Ala Leu Pro Leu Cys Leu Leu Met Ala Gln Gln Arg Asn Gly 

            740                 745                 750         





Val Ile Phe Gln Glu Gly Gly Glu Lys His Leu Lys Leu Val Gly Lys 

        755                 760                 765             





Leu Tyr Asp Gln Cys His Asp Thr Leu Val Gln Phe Gly Gly Phe Leu 

    770                 775                 780                 





Ala Ser Asn Leu Ser Thr Glu Asp Tyr Ile Lys Arg Val Pro Ser Ile 

785                 790                 795                 800 





Asp Val Leu Cys Asn Glu Phe His Thr Pro His Asp Ala Ala Phe Phe 

                805                 810                 815     





Leu Ser Arg Pro Met Tyr Ala His His Ile Ser Ser Lys Tyr Asp Glu 

            820                 825                 830         





Leu Lys Lys Ser Glu Lys Gly Ser Lys Gln Gln His Lys Val His Lys 

        835                 840                 845             





Tyr Ile Thr Ser Cys Glu Met Val Met Ala Pro Val His Glu Ala Val 

    850                 855                 860                 





Val Ser Leu His Val Ser Lys Val Trp Asp Asp Ile Ser Pro Gln Phe 

865                 870                 875                 880 





Tyr Ala Thr Phe Trp Ser Leu Thr Met Tyr Asp Leu Ala Val Pro His 

                885                 890                 895     





Thr Ser Tyr Glu Arg Glu Val Asn Lys Leu Lys Val Gln Met Lys Ala 

            900                 905                 910         





Ile Asp Asp Asn Gln Glu Met Pro Pro Asn Lys Lys Lys Lys Glu Lys 

        915                 920                 925             





Glu Arg Cys Thr Ala Leu Gln Asp Lys Leu Leu Glu Glu Glu Lys Lys 

    930                 935                 940                 





Gln Met Glu His Val Gln Arg Val Leu Gln Arg Leu Lys Leu Glu Lys 

945                 950                 955                 960 





Asp Asn Trp Leu Leu Ala Lys Ser Thr Lys Asn Glu Thr Ile Thr Lys 

                965                 970                 975     





Phe Leu Gln Leu Cys Ile Phe Pro Arg Cys Ile Phe Ser Ala Ile Asp 

            980                 985                 990         





Ala Val Tyr Cys Ala Arg Phe Val  Glu Leu Val His Gln  Gln Lys Thr 

        995                 1000                 1005             





Pro Asn  Phe Ser Thr Leu Leu  Cys Tyr Asp Arg Val  Phe Ser Asp 

    1010                 1015                 1020             





Ile Ile  Tyr Thr Val Ala Ser  Cys Thr Glu Asn Glu  Ala Ser Arg 

    1025                 1030                 1035             





Tyr Gly  Arg Phe Leu Cys Cys  Met Leu Glu Thr Val  Thr Arg Trp 

    1040                 1045                 1050             





His Ser  Asp Arg Ala Thr Tyr  Glu Lys Glu Cys Gly  Asn Tyr Pro 

    1055                 1060                 1065             





Gly Phe  Leu Thr Ile Leu Arg  Ala Thr Gly Phe Asp  Gly Gly Asn 

    1070                 1075                 1080             





Lys Ala  Asp Gln Leu Asp Tyr  Glu Asn Phe Arg His  Val Val His 

    1085                 1090                 1095             





Lys Trp  His Tyr Lys Leu Thr  Lys Ala Ser Val His  Cys Leu Glu 

    1100                 1105                 1110             





Thr Gly  Glu Tyr Thr His Ile  Arg Asn Ile Leu Ile  Val Leu Thr 

    1115                 1120                 1125             





Lys Ile  Leu Pro Trp Tyr Pro  Lys Val Leu Asn Leu  Gly Gln Ala 

    1130                 1135                 1140             





Leu Glu  Arg Arg Val His Lys  Ile Cys Gln Glu Glu  Lys Glu Lys 

    1145                 1150                 1155             





Arg Pro  Asp Leu Tyr Ala Leu  Ala Met Gly Tyr Ser  Gly Gln Leu 

    1160                 1165                 1170             





Lys Ser  Arg Lys Ser Tyr Met  Ile Pro Glu Asn Glu  Phe His His 

    1175                 1180                 1185             





Lys Asp  Pro Pro Pro Arg Asn  Ala Val Ala Ser Val  Gln Asn Gly 

    1190                 1195                 1200             





Pro Gly  Gly Gly Pro Ser Ser  Ser Ser Ile Gly Ser  Ala Ser Lys 

    1205                 1210                 1215             





Ser Asp  Glu Ser Ser Thr Glu  Glu Thr Asp Lys Ser  Arg Glu Arg 

    1220                 1225                 1230             





Ser Gln  Cys Gly Val Lys Ala  Val Asn Lys Ala Ser  Ser Thr Thr 

    1235                 1240                 1245             





Pro Lys  Gly Asn Ser Ser Asn  Gly Asn Ser Gly Ser  Asn Ser Asn 

    1250                 1255                 1260             





Lys Ala  Val Lys Glu Asn Asp  Lys Glu Lys Gly Lys  Glu Lys Glu 

    1265                 1270                 1275             





Lys Glu  Lys Lys Glu Lys Thr  Pro Ala Thr Thr Pro  Glu Ala Arg 

    1280                 1285                 1290             





Val Leu  Gly Lys Asp Gly Lys  Glu Lys Pro Lys Glu  Glu Arg Pro 

    1295                 1300                 1305             





Asn Lys  Asp Glu Lys Ala Arg  Glu Thr Lys Glu Arg  Thr Pro Lys 

    1310                 1315                 1320             





Ser Asp  Lys Glu Lys Glu Lys  Phe Lys Lys Glu Glu  Lys Ala Lys 

    1325                 1330                 1335             





Asp Glu  Lys Phe Lys Thr Thr  Val Pro Asn Ala Glu  Ser Lys Ser 

    1340                 1345                 1350             





Thr Gln  Glu Arg Glu Arg Glu  Lys Glu Pro Ser Arg  Glu Arg Asp 

    1355                 1360                 1365             





Ile Ala  Lys Glu Met Lys Ser  Lys Glu Asn Val Lys  Gly Gly Glu 

    1370                 1375                 1380             





Lys Thr  Pro Val Ser Gly Ser  Leu Lys Ser Pro Val  Pro Arg Ser 

    1385                 1390                 1395             





Asp Ile  Pro Glu Pro Glu Arg  Glu Gln Lys Arg Arg  Lys Ile Asp 

    1400                 1405                 1410             





Thr His  Pro Ser Pro Ser His  Ser Ser Thr Val Lys  Asp Ser Leu 

    1415                 1420                 1425             





Ile Glu  Leu Lys Glu Ser Ser  Ala Lys Leu Tyr Ile  Asn His Thr 

    1430                 1435                 1440             





Pro Pro  Pro Leu Ser Lys Ser  Lys Glu Arg Glu Met  Asp Lys Lys 

    1445                 1450                 1455             





Asp Leu  Asp Lys Ser Arg Glu  Arg Ser Arg Glu Arg  Glu Lys Lys 

    1460                 1465                 1470             





Asp Glu  Lys Asp Arg Lys Glu  Arg Lys Arg Asp His  Ser Asn Asn 

    1475                 1480                 1485             





Asp Arg  Glu Val Pro Pro Asp  Leu Thr Lys Arg Arg  Lys Glu Glu 

    1490                 1495                 1500             





Asn Gly  Thr Met Gly Val Ser  Lys His Lys Ser Glu  Ser Pro Cys 

    1505                 1510                 1515             





Glu Ser  Pro Tyr Pro Asn Glu  Lys Asp Lys Glu Lys  Asn Lys Ser 

    1520                 1525                 1530             





Lys Ser  Ser Gly Lys Glu Lys  Gly Ser Asp Ser Phe  Lys Ser Glu 

    1535                 1540                 1545             





Lys Met  Asp Lys Ile Ser Ser  Gly Gly Lys Lys Glu  Ser Arg His 

    1550                 1555                 1560             





Asp Lys  Glu Lys Ile Glu Lys  Lys Glu Lys Arg Asp  Ser Ser Gly 

    1565                 1570                 1575             





Gly Lys  Glu Glu Lys Lys His  His Lys Ser Ser Asp  Lys His Arg 

    1580                 1585                 1590             





<210>  314

<211>  2668

<212>  DNA

<213>  Homo sapiens



<400>  314

ttcattgcct ggggatgaga gggagagaca acgtgtgtct tacacatctc ccaacagccg       60



acttagatgt gatccgttct cccagaggga gcaggtttct ttgaactttt cctttttatg      120



tacagcatag tgctgagcag atcactgcac tgtgcaggag ttttaacgac agtcaggcca      180



acggcatgga aggaccgcgg gagaatcagg atcctcctcc gaggcctctg gcccgccacc      240



tgtctgatgc agaccgcctc cgcaaagtca tccaggagct tgtggacaca gagaagtcct      300



acgtgaagga tttgagctgc ctctttgaat tatacttgga gccacttcag aatgagacct      360



ttcttaccca agatgagatg gagtcacttt ttggaagttt gccagagatg cttgagtttc      420



agaaggtgtt tctggagacc ctggaggatg ggatttcagc atcatctgac tttaacaccc      480



tagaaacccc ctcacagttt agaaaattac tgttttccct tggaggctct ttcctttatt      540



acgcggacca ctttaaactg tacagtggat tctgtgctaa ccatatcaaa gtacagaagg      600



ttctggagcg agctaaaact gacaaagcct tcaaggcttt tctggacgcc cggaacccca      660



ccaagcagca ttcctccacg ctggagtcct acctcatcaa gccggttcag agagtgctca      720



agtacccgct gctgctcaag gagctggtgt ccctgacgga ccaggagagc gaggagcact      780



accacctgac ggaagcacta aaggcaatgg agaaagtagc gagccacatc aatgagatgc      840



agaagatcta tgaggattat gggaccgtgt ttgaccagct agtagctgag cagagcggaa      900



cagagaagga ggtaacagaa ctttcgatgg gagagcttct gatgcactct acggtttcct      960



ggttgaatcc atttctgtct ctaggaaaag ctagaaagga ccttgagctc acagtatttg     1020



tttttaagag agccgtcata ctggtttata aagaaaactg caaactgaaa aagaaattgc     1080



cctcgaattc ccggcctgca cacaactcta ctgacttgga cccatttaaa ttccgctggt     1140



tgatccccat ctccgcgctt caagtcagac tggggaatcc agcagggaca gaaaataatt     1200



ccatatggga actgatccat acgaagtcag aaatagaagg acggccagaa accatctttc     1260



agttgtgttg cagtgacagt gaaagcaaaa ccaacattgt taaggtgatt cgttctattc     1320



tgagggagaa cttcaggcgt cacataaagt gtgaattacc actggagaaa acgtgtaagg     1380



atcgcctggt acctcttaag aaccgagttc ctgtttcggc caaattagct tcatccaggt     1440



ctttaaaagt cctgaagaat tcctccagca acgagtggac cggtgagact ggcaagggaa     1500



ccttgctgga ctctgacgag ggcagcttga gcagcggcac ccagagcagc ggctgcccca     1560



cggctgaggg caggcaggac tccaagagca cttctcccgg gaaataccca caccccggct     1620



tggcagattt tgccgacaat ctcatcaaag agagtgacat cctgagcgat gaagatgatg     1680



accaccgtca gactgtgaag cagggcagcc ctactaaaga catcgaaatt cagttccaga     1740



gactgaggat ttccgaggac ccagacgttc accccgaggc tgagcagcag cctggcccgg     1800



agtcgggtga gggtcagaaa ggaggagagc agcccaaact ggtccggggg cacttctgcc     1860



ccattaaacg aaaagccaac agcaccaaga gggacagagg aactttgctc aaggcgcaga     1920



tccgtcacca gtcccttgac agtcagtctg aaaatgccac catcgaccta aattctgttc     1980



tagagcgaga attcagtgtc cagagtttaa catctgttgt cagtgaggag tgtttttatg     2040



aaacagagag ccacggaaaa tcatagtatg attcaatcca gatatgggtt aaattcctca     2100



ttttactttt aaactggtgg taaagtggaa attgcaaaaa aaaaaaaaaa aaaaaactgt     2160



tcattcctgg gttttgtgca gtatacattt tcccacaaaa tggttgtaaa gatttaagtt     2220



attttaattt attgtggatc agaaacctag atgaaactgg tcagaatctg taaattactt     2280



agtttatatc cactttgagc aggtatcaaa tgatttagga tccttaaaat tacattctaa     2340



taattaagtt atgtggaaaa agtaaggctg gggaagtcgt gattaatagt tttcaaaggg     2400



ccatttttta aaatcctctg ggcattttct ttcagctgtt tgttagtttt tgctttattt     2460



aaagcatatt taagttattt taatgtggtt taggggcaaa atgtgcagat acttcatttt     2520



tgtaagatag attgtaatag atgctgttta tactaaacat gtcataacta tctatacagt     2580



atatattaaa agaaagcttg tactgtatct tatttgatga tatttatttt ctctgccaag     2640



ctgtatagta aaaggaaaat aagtcaca                                        2668





<210>  315

<211>  626

<212>  PRT

<213>  Homo sapiens



<400>  315



Met Glu Gly Pro Arg Glu Asn Gln Asp Pro Pro Pro Arg Pro Leu Ala 

1               5                   10                  15      





Arg His Leu Ser Asp Ala Asp Arg Leu Arg Lys Val Ile Gln Glu Leu 

            20                  25                  30          





Val Asp Thr Glu Lys Ser Tyr Val Lys Asp Leu Ser Cys Leu Phe Glu 

        35                  40                  45              





Leu Tyr Leu Glu Pro Leu Gln Asn Glu Thr Phe Leu Thr Gln Asp Glu 

    50                  55                  60                  





Met Glu Ser Leu Phe Gly Ser Leu Pro Glu Met Leu Glu Phe Gln Lys 

65                  70                  75                  80  





Val Phe Leu Glu Thr Leu Glu Asp Gly Ile Ser Ala Ser Ser Asp Phe 

                85                  90                  95      





Asn Thr Leu Glu Thr Pro Ser Gln Phe Arg Lys Leu Leu Phe Ser Leu 

            100                 105                 110         





Gly Gly Ser Phe Leu Tyr Tyr Ala Asp His Phe Lys Leu Tyr Ser Gly 

        115                 120                 125             





Phe Cys Ala Asn His Ile Lys Val Gln Lys Val Leu Glu Arg Ala Lys 

    130                 135                 140                 





Thr Asp Lys Ala Phe Lys Ala Phe Leu Asp Ala Arg Asn Pro Thr Lys 

145                 150                 155                 160 





Gln His Ser Ser Thr Leu Glu Ser Tyr Leu Ile Lys Pro Val Gln Arg 

                165                 170                 175     





Val Leu Lys Tyr Pro Leu Leu Leu Lys Glu Leu Val Ser Leu Thr Asp 

            180                 185                 190         





Gln Glu Ser Glu Glu His Tyr His Leu Thr Glu Ala Leu Lys Ala Met 

        195                 200                 205             





Glu Lys Val Ala Ser His Ile Asn Glu Met Gln Lys Ile Tyr Glu Asp 

    210                 215                 220                 





Tyr Gly Thr Val Phe Asp Gln Leu Val Ala Glu Gln Ser Gly Thr Glu 

225                 230                 235                 240 





Lys Glu Val Thr Glu Leu Ser Met Gly Glu Leu Leu Met His Ser Thr 

                245                 250                 255     





Val Ser Trp Leu Asn Pro Phe Leu Ser Leu Gly Lys Ala Arg Lys Asp 

            260                 265                 270         





Leu Glu Leu Thr Val Phe Val Phe Lys Arg Ala Val Ile Leu Val Tyr 

        275                 280                 285             





Lys Glu Asn Cys Lys Leu Lys Lys Lys Leu Pro Ser Asn Ser Arg Pro 

    290                 295                 300                 





Ala His Asn Ser Thr Asp Leu Asp Pro Phe Lys Phe Arg Trp Leu Ile 

305                 310                 315                 320 





Pro Ile Ser Ala Leu Gln Val Arg Leu Gly Asn Pro Ala Gly Thr Glu 

                325                 330                 335     





Asn Asn Ser Ile Trp Glu Leu Ile His Thr Lys Ser Glu Ile Glu Gly 

            340                 345                 350         





Arg Pro Glu Thr Ile Phe Gln Leu Cys Cys Ser Asp Ser Glu Ser Lys 

        355                 360                 365             





Thr Asn Ile Val Lys Val Ile Arg Ser Ile Leu Arg Glu Asn Phe Arg 

    370                 375                 380                 





Arg His Ile Lys Cys Glu Leu Pro Leu Glu Lys Thr Cys Lys Asp Arg 

385                 390                 395                 400 





Leu Val Pro Leu Lys Asn Arg Val Pro Val Ser Ala Lys Leu Ala Ser 

                405                 410                 415     





Ser Arg Ser Leu Lys Val Leu Lys Asn Ser Ser Ser Asn Glu Trp Thr 

            420                 425                 430         





Gly Glu Thr Gly Lys Gly Thr Leu Leu Asp Ser Asp Glu Gly Ser Leu 

        435                 440                 445             





Ser Ser Gly Thr Gln Ser Ser Gly Cys Pro Thr Ala Glu Gly Arg Gln 

    450                 455                 460                 





Asp Ser Lys Ser Thr Ser Pro Gly Lys Tyr Pro His Pro Gly Leu Ala 

465                 470                 475                 480 





Asp Phe Ala Asp Asn Leu Ile Lys Glu Ser Asp Ile Leu Ser Asp Glu 

                485                 490                 495     





Asp Asp Asp His Arg Gln Thr Val Lys Gln Gly Ser Pro Thr Lys Asp 

            500                 505                 510         





Ile Glu Ile Gln Phe Gln Arg Leu Arg Ile Ser Glu Asp Pro Asp Val 

        515                 520                 525             





His Pro Glu Ala Glu Gln Gln Pro Gly Pro Glu Ser Gly Glu Gly Gln 

    530                 535                 540                 





Lys Gly Gly Glu Gln Pro Lys Leu Val Arg Gly His Phe Cys Pro Ile 

545                 550                 555                 560 





Lys Arg Lys Ala Asn Ser Thr Lys Arg Asp Arg Gly Thr Leu Leu Lys 

                565                 570                 575     





Ala Gln Ile Arg His Gln Ser Leu Asp Ser Gln Ser Glu Asn Ala Thr 

            580                 585                 590         





Ile Asp Leu Asn Ser Val Leu Glu Arg Glu Phe Ser Val Gln Ser Leu 

        595                 600                 605             





Thr Ser Val Val Ser Glu Glu Cys Phe Tyr Glu Thr Glu Ser His Gly 

    610                 615                 620                 





Lys Ser 

625     





<210>  316

<211>  5916

<212>  DNA

<213>  Homo sapiens



<400>  316

ggctctgtgt atgaatgaca aggatacctt cagccagctc attctggatg aatgaatgat       60



tacactaagt gtcctccaca ttcctctgtg ggctcacttc atggactcac tttgcgtgct      120



tgttaaatgt gctgtgttgc tcccaagacc atgtaaagcc tactgaccac taacctccct      180



cacagcagaa actagacgtc aggttaaaat gggcaactcc gacagtcagt acacccttca      240



aggatctaaa aatcatagca atactattac tggtgctaag caaattcctt gctccctgaa      300



aatacgtggc attcatgcaa aagaggaaaa gtcattgcat ggatggggtc acggaagcaa      360



cggagcaggt tacaagtcca ggtccctggc ccgaagctgc ctttctcact ttaagagtaa      420



ccagccttac gcatcgagac tcggtggccc cacatgcaag gtctccagag gtgttgccta      480



ctccacgcac aggacaaatg ccccagggaa ggatttccag ggcatcagtg ctgctttctc      540



aactgagaat ggcttccact ctgttggcca cgagctggca gataaccaca tcacctccag      600



agactgcaac ggacaccttc tcaactgcta cgggaggaat gagagcattg cctccacccc      660



accgggcgaa gaccgcaaga gcccccgagt gctcatcaaa acgctgggga agctggatgg      720



gtgtttaagg gtcgagttcc acaatggtgg caaccccagc aaagtgcctg cagaggactg      780



cagtgagccg gtgcagctgc tgaggtactc acctacctta gcatcggaaa cctcccctgt      840



gcctgaagcc aggagggggt ccagcgccga ttccctgccc agccatcgcc cctctcccac      900



ggactctcgc ctgcggtcca gcaaaggcag ctccctgagt tctgagtcat cctggtacga      960



ctccccttgg ggcaatgctg gagagctgag cgaggctgag ggctccttcc tggcccccgg     1020



catgcctgac cccagtctcc atgccagctt cccacctggc gatgccaaaa agcctttcaa     1080



ccaaagctct tccctctcct ccctccggga actgtacaaa gatgccaacc tggggagcct     1140



ctccccctca ggtatccgcc tttctgatga atacatgggc acgcatgcca gcctgagcaa     1200



ccgtgtctct tttgcttccg acattgatgt gccctccaga gtggcacacg gggaccccat     1260



ccagtacagt tccttcactc tcccctgtcg gaagcccaaa gcctttgttg aggatactgc     1320



gaagaaggac tccctcaaag ccaggatgcg acggatcagt gactggacgg gaagcctctc     1380



aaggaagaaa aggaaactcc aggagccgag gtccaaggag ggcagtgact actttgacag     1440



tcgctctgat ggactgaata cagatgtgca gggatcctcc caggcatctg cttttctgtg     1500



gtcagggggc tctactcaga tcctgtctca gagaagtgaa tccacacatg cgattggcag     1560



cgatcccctc cggcagaaca tttatgagaa tttcatgcga gagttggaaa tgagcaggac     1620



caacactgag aacatagaaa catctacaga aaccgccgag tccagcagcg agtcactcag     1680



ctctctggaa cagctggatc tgctctttga gaaggaacag ggggtggtcc ggaaggccgg     1740



gtggctcttc ttcaagcccc tggtcactgt gcagaaggaa aggaagcttg agctggtggc     1800



acgaaggaaa tggaaacagt actgggtaac gctgaaagga tgcacgctgc tgttttatga     1860



gacctatggg aagaattcca tggatcagag cagtgcccct cggtgtgctc tgtttgcaga     1920



agacagcata gtgcagtctg ttccagagca tcccaagaaa gaaaatgtgt tctgcctcag     1980



caactccttt ggagatgtct accttttcca ggccaccagc cagacagatc tagaaaactg     2040



ggtcactgct gtacactctg cttgtgcatc cctttttgca aagaagcatg ggaaagagga     2100



cacgctgcgg ctgctgaaga accagaccaa aaacctgctt cagaagatag acatggacag     2160



caagatgaag aagatggcag agctgcagct gtccgtggtg agcgacccaa agaacaggaa     2220



agccatagag aaccagatcc agcaatggga gcagaatctt gagaaatttc acatggatct     2280



gttcaggatg cgctgctatc tggccagcct acaaggtggg gagttaccga acccaaagag     2340



tctccttgca gccgccagcc gcccctccaa gctggccctc ggcaggctgg gcatcttgtc     2400



tgtttcctct ttccatgctc tggtatgttc tagagatgac tctgctctcc ggaaaaggac     2460



actgtcactg acccagcgag ggagaaacaa gaagggaata ttttcttcgt taaaagggct     2520



ggacacactg gccagaaaag gcaaggagaa gagaccttct ataactcagg tcgatgaact     2580



tctgcatata tatggttcaa cagtagacgg tgttccccga gacaatgcat gggaaatcca     2640



gacttatgtc cactttcagg acaatcacgg agttactgta gggatcaagc cagagcacag     2700



agtagaagat attttgactt tggcatgcaa gatgaggcag ttggaaccca gccattatgg     2760



cctacagctt cgaaaattag tagatgacaa tgttgagtat tgcatccctg caccatatga     2820



atatatgcaa caacaggttt atgatgaaat agaagtcttt ccactaaatg tttatgacgt     2880



gcagctcacg aagactggga gtgtgtgtga ctttgggttt gcagttacag cgcaggtgga     2940



tgagcgtcag catctcagcc ggatatttat aagcgacgtt cttcccgatg gcctggcgta     3000



tggggaaggg ctgagaaagg gcaatgagat catgacctta aatggggaag ctgtgtctga     3060



tcttgacctt aagcagatgg aggccctgtt ttctgagaag agcgtcggac tcactctgat     3120



tgcccggcct ccggacacaa aagcaaccct gtgtacatcc tggtcagaca gtgacctgtt     3180



ctccagggac cagaagagtc tgctgccccc tcctaaccag tcccaactgc tggaggaatt     3240



cctggataac tttaaaaaga atacagccaa tgatttcagc aacgtccctg atatcacaac     3300



aggtctgaaa aggagtcaga cagatggcac tctggatcag gtttcccaca gggagaaaat     3360



ggagcagaca ttcaggagtg ctgagcagat cactgcactg tgcaggagtt ttaacgacag     3420



tcaggccaac ggcatggaag gaccgcggga gaatcaggat cctcctccga ggcctctggc     3480



ccgccacctg tctgatgcag accgcctccg caaagtcatc caggagcttg tggacacaga     3540



gaagtcctac gtgaaggatt tgagctgcct ctttgaatta tacttggagc cacttcagaa     3600



tgagaccttt cttacccaag atgagatgga gtcacttttt ggaagtttgc cagagatgct     3660



tgagtttcag aaggtgtttc tggagaccct ggaggatggg atttcagcat catctgactt     3720



taacacccta gaaaccccct cacagtttag aaaattactg ttttcccttg gaggctcttt     3780



cctttattac gcggaccact ttaaactgta cagtggattc tgtgctaacc atatcaaagt     3840



acagaaggtt ctggagcgag ctaaaactga caaagccttc aaggcttttc tggacgcccg     3900



gaaccccacc aagcagcatt cctccacgct ggagtcctac ctcatcaagc cggttcagag     3960



agtgctcaag tacccgctgc tgctcaagga gctggtgtcc ctgacggacc aggagagcga     4020



ggagcactac cacctgacgg aagcactaaa ggcaatggag aaagtagcga gccacatcaa     4080



tgagatgcag aagatctatg aggattatgg gaccgtgttt gaccagctag tagctgagca     4140



gagcggaaca gagaaggagg taacagaact ttcgatggga gagcttctga tgcactctac     4200



ggtttcctgg ttgaatccat ttctgtctct aggaaaagct agaaaggacc ttgagctcac     4260



agtatttgtt tttaagagag ccgtcatact ggtttataaa gaaaactgca aactgaaaaa     4320



gaaattgccc tcgaattccc ggcctgcaca caactctact gacttggacc catttaaatt     4380



ccgctggttg atccccatct ccgcgcttca agtcagactg gggaatccag cagggacaga     4440



aaataattcc atatgggaac tgatccatac gaagtcagaa atagaaggac ggccagaaac     4500



catctttcag ttgtgttgca gtgacagtga aagcaaaacc aacattgtta aggtgattcg     4560



ttctattctg agggagaact tcaggcgtca cataaagtgt gaattaccac tggagaaaac     4620



gtgtaaggat cgcctggtac ctcttaagaa ccgagttcct gtttcggcca aattagcttc     4680



atccaggtct ttaaaagtcc tgaagaattc ctccagcaac gagtggaccg gtgagactgg     4740



caagggaacc ttgctggact ctgacgaggg cagcttgagc agcggcaccc agagcagcgg     4800



ctgccccacg gctgagggca ggcaggactc caagagcact tctcccggga aatacccaca     4860



ccccggcttg gcagattttg ccgacaatct catcaaagag agtgacatcc tgagcgatga     4920



agatgatgac caccgtcaga ctgtgaagca gggcagccct actaaagaca tcgaaattca     4980



gttccagaga ctgaggattt ccgaggaccc agacgttcac cccgaggctg agcagcagcc     5040



tggcccggag tcgggtgagg gtcagaaagg aggagagcag cccaaactgg tccgggggca     5100



cttctgcccc attaaacgaa aagccaacag caccaagagg gacagaggaa ctttgctcaa     5160



ggcgcagatc cgtcaccagt cccttgacag tcagtctgaa aatgccacca tcgacctaaa     5220



ttctgttcta gagcgagaat tcagtgtcca gagtttaaca tctgttgtca gtgaggagtg     5280



tttttatgaa acagagagcc acggaaaatc atagtatgat tcaatccaga tatgggttaa     5340



attcctcatt ttacttttaa actggtggta aagtggaaat tgcaaaaaaa aaaaaaaaaa     5400



aaaactgttc attcctgggt tttgtgcagt atacattttc ccacaaaatg gttgtaaaga     5460



tttaagttat tttaatttat tgtggatcag aaacctagat gaaactggtc agaatctgta     5520



aattacttag tttatatcca ctttgagcag gtatcaaatg atttaggatc cttaaaatta     5580



cattctaata attaagttat gtggaaaaag taaggctggg gaagtcgtga ttaatagttt     5640



tcaaagggcc attttttaaa atcctctggg cattttcttt cagctgtttg ttagtttttg     5700



ctttatttaa agcatattta agttatttta atgtggttta ggggcaaaat gtgcagatac     5760



ttcatttttg taagatagat tgtaatagat gctgtttata ctaaacatgt cataactatc     5820



tatacagtat atattaaaag aaagcttgta ctgtatctta tttgatgata tttattttct     5880



ctgccaagct gtatagtaaa aggaaaataa gtcaca                               5916





<210>  317

<211>  1701

<212>  PRT

<213>  Homo sapiens



<400>  317



Met Gly Asn Ser Asp Ser Gln Tyr Thr Leu Gln Gly Ser Lys Asn His 

1               5                   10                  15      





Ser Asn Thr Ile Thr Gly Ala Lys Gln Ile Pro Cys Ser Leu Lys Ile 

            20                  25                  30          





Arg Gly Ile His Ala Lys Glu Glu Lys Ser Leu His Gly Trp Gly His 

        35                  40                  45              





Gly Ser Asn Gly Ala Gly Tyr Lys Ser Arg Ser Leu Ala Arg Ser Cys 

    50                  55                  60                  





Leu Ser His Phe Lys Ser Asn Gln Pro Tyr Ala Ser Arg Leu Gly Gly 

65                  70                  75                  80  





Pro Thr Cys Lys Val Ser Arg Gly Val Ala Tyr Ser Thr His Arg Thr 

                85                  90                  95      





Asn Ala Pro Gly Lys Asp Phe Gln Gly Ile Ser Ala Ala Phe Ser Thr 

            100                 105                 110         





Glu Asn Gly Phe His Ser Val Gly His Glu Leu Ala Asp Asn His Ile 

        115                 120                 125             





Thr Ser Arg Asp Cys Asn Gly His Leu Leu Asn Cys Tyr Gly Arg Asn 

    130                 135                 140                 





Glu Ser Ile Ala Ser Thr Pro Pro Gly Glu Asp Arg Lys Ser Pro Arg 

145                 150                 155                 160 





Val Leu Ile Lys Thr Leu Gly Lys Leu Asp Gly Cys Leu Arg Val Glu 

                165                 170                 175     





Phe His Asn Gly Gly Asn Pro Ser Lys Val Pro Ala Glu Asp Cys Ser 

            180                 185                 190         





Glu Pro Val Gln Leu Leu Arg Tyr Ser Pro Thr Leu Ala Ser Glu Thr 

        195                 200                 205             





Ser Pro Val Pro Glu Ala Arg Arg Gly Ser Ser Ala Asp Ser Leu Pro 

    210                 215                 220                 





Ser His Arg Pro Ser Pro Thr Asp Ser Arg Leu Arg Ser Ser Lys Gly 

225                 230                 235                 240 





Ser Ser Leu Ser Ser Glu Ser Ser Trp Tyr Asp Ser Pro Trp Gly Asn 

                245                 250                 255     





Ala Gly Glu Leu Ser Glu Ala Glu Gly Ser Phe Leu Ala Pro Gly Met 

            260                 265                 270         





Pro Asp Pro Ser Leu His Ala Ser Phe Pro Pro Gly Asp Ala Lys Lys 

        275                 280                 285             





Pro Phe Asn Gln Ser Ser Ser Leu Ser Ser Leu Arg Glu Leu Tyr Lys 

    290                 295                 300                 





Asp Ala Asn Leu Gly Ser Leu Ser Pro Ser Gly Ile Arg Leu Ser Asp 

305                 310                 315                 320 





Glu Tyr Met Gly Thr His Ala Ser Leu Ser Asn Arg Val Ser Phe Ala 

                325                 330                 335     





Ser Asp Ile Asp Val Pro Ser Arg Val Ala His Gly Asp Pro Ile Gln 

            340                 345                 350         





Tyr Ser Ser Phe Thr Leu Pro Cys Arg Lys Pro Lys Ala Phe Val Glu 

        355                 360                 365             





Asp Thr Ala Lys Lys Asp Ser Leu Lys Ala Arg Met Arg Arg Ile Ser 

    370                 375                 380                 





Asp Trp Thr Gly Ser Leu Ser Arg Lys Lys Arg Lys Leu Gln Glu Pro 

385                 390                 395                 400 





Arg Ser Lys Glu Gly Ser Asp Tyr Phe Asp Ser Arg Ser Asp Gly Leu 

                405                 410                 415     





Asn Thr Asp Val Gln Gly Ser Ser Gln Ala Ser Ala Phe Leu Trp Ser 

            420                 425                 430         





Gly Gly Ser Thr Gln Ile Leu Ser Gln Arg Ser Glu Ser Thr His Ala 

        435                 440                 445             





Ile Gly Ser Asp Pro Leu Arg Gln Asn Ile Tyr Glu Asn Phe Met Arg 

    450                 455                 460                 





Glu Leu Glu Met Ser Arg Thr Asn Thr Glu Asn Ile Glu Thr Ser Thr 

465                 470                 475                 480 





Glu Thr Ala Glu Ser Ser Ser Glu Ser Leu Ser Ser Leu Glu Gln Leu 

                485                 490                 495     





Asp Leu Leu Phe Glu Lys Glu Gln Gly Val Val Arg Lys Ala Gly Trp 

            500                 505                 510         





Leu Phe Phe Lys Pro Leu Val Thr Val Gln Lys Glu Arg Lys Leu Glu 

        515                 520                 525             





Leu Val Ala Arg Arg Lys Trp Lys Gln Tyr Trp Val Thr Leu Lys Gly 

    530                 535                 540                 





Cys Thr Leu Leu Phe Tyr Glu Thr Tyr Gly Lys Asn Ser Met Asp Gln 

545                 550                 555                 560 





Ser Ser Ala Pro Arg Cys Ala Leu Phe Ala Glu Asp Ser Ile Val Gln 

                565                 570                 575     





Ser Val Pro Glu His Pro Lys Lys Glu Asn Val Phe Cys Leu Ser Asn 

            580                 585                 590         





Ser Phe Gly Asp Val Tyr Leu Phe Gln Ala Thr Ser Gln Thr Asp Leu 

        595                 600                 605             





Glu Asn Trp Val Thr Ala Val His Ser Ala Cys Ala Ser Leu Phe Ala 

    610                 615                 620                 





Lys Lys His Gly Lys Glu Asp Thr Leu Arg Leu Leu Lys Asn Gln Thr 

625                 630                 635                 640 





Lys Asn Leu Leu Gln Lys Ile Asp Met Asp Ser Lys Met Lys Lys Met 

                645                 650                 655     





Ala Glu Leu Gln Leu Ser Val Val Ser Asp Pro Lys Asn Arg Lys Ala 

            660                 665                 670         





Ile Glu Asn Gln Ile Gln Gln Trp Glu Gln Asn Leu Glu Lys Phe His 

        675                 680                 685             





Met Asp Leu Phe Arg Met Arg Cys Tyr Leu Ala Ser Leu Gln Gly Gly 

    690                 695                 700                 





Glu Leu Pro Asn Pro Lys Ser Leu Leu Ala Ala Ala Ser Arg Pro Ser 

705                 710                 715                 720 





Lys Leu Ala Leu Gly Arg Leu Gly Ile Leu Ser Val Ser Ser Phe His 

                725                 730                 735     





Ala Leu Val Cys Ser Arg Asp Asp Ser Ala Leu Arg Lys Arg Thr Leu 

            740                 745                 750         





Ser Leu Thr Gln Arg Gly Arg Asn Lys Lys Gly Ile Phe Ser Ser Leu 

        755                 760                 765             





Lys Gly Leu Asp Thr Leu Ala Arg Lys Gly Lys Glu Lys Arg Pro Ser 

    770                 775                 780                 





Ile Thr Gln Val Asp Glu Leu Leu His Ile Tyr Gly Ser Thr Val Asp 

785                 790                 795                 800 





Gly Val Pro Arg Asp Asn Ala Trp Glu Ile Gln Thr Tyr Val His Phe 

                805                 810                 815     





Gln Asp Asn His Gly Val Thr Val Gly Ile Lys Pro Glu His Arg Val 

            820                 825                 830         





Glu Asp Ile Leu Thr Leu Ala Cys Lys Met Arg Gln Leu Glu Pro Ser 

        835                 840                 845             





His Tyr Gly Leu Gln Leu Arg Lys Leu Val Asp Asp Asn Val Glu Tyr 

    850                 855                 860                 





Cys Ile Pro Ala Pro Tyr Glu Tyr Met Gln Gln Gln Val Tyr Asp Glu 

865                 870                 875                 880 





Ile Glu Val Phe Pro Leu Asn Val Tyr Asp Val Gln Leu Thr Lys Thr 

                885                 890                 895     





Gly Ser Val Cys Asp Phe Gly Phe Ala Val Thr Ala Gln Val Asp Glu 

            900                 905                 910         





Arg Gln His Leu Ser Arg Ile Phe Ile Ser Asp Val Leu Pro Asp Gly 

        915                 920                 925             





Leu Ala Tyr Gly Glu Gly Leu Arg Lys Gly Asn Glu Ile Met Thr Leu 

    930                 935                 940                 





Asn Gly Glu Ala Val Ser Asp Leu Asp Leu Lys Gln Met Glu Ala Leu 

945                 950                 955                 960 





Phe Ser Glu Lys Ser Val Gly Leu Thr Leu Ile Ala Arg Pro Pro Asp 

                965                 970                 975     





Thr Lys Ala Thr Leu Cys Thr Ser Trp Ser Asp Ser Asp Leu Phe Ser 

            980                 985                 990         





Arg Asp Gln Lys Ser Leu Leu Pro  Pro Pro Asn Gln Ser  Gln Leu Leu 

        995                 1000                 1005             





Glu Glu  Phe Leu Asp Asn Phe  Lys Lys Asn Thr Ala  Asn Asp Phe 

    1010                 1015                 1020             





Ser Asn  Val Pro Asp Ile Thr  Thr Gly Leu Lys Arg  Ser Gln Thr 

    1025                 1030                 1035             





Asp Gly  Thr Leu Asp Gln Val  Ser His Arg Glu Lys  Met Glu Gln 

    1040                 1045                 1050             





Thr Phe  Arg Ser Ala Glu Gln  Ile Thr Ala Leu Cys  Arg Ser Phe 

    1055                 1060                 1065             





Asn Asp  Ser Gln Ala Asn Gly  Met Glu Gly Pro Arg  Glu Asn Gln 

    1070                 1075                 1080             





Asp Pro  Pro Pro Arg Pro Leu  Ala Arg His Leu Ser  Asp Ala Asp 

    1085                 1090                 1095             





Arg Leu  Arg Lys Val Ile Gln  Glu Leu Val Asp Thr  Glu Lys Ser 

    1100                 1105                 1110             





Tyr Val  Lys Asp Leu Ser Cys  Leu Phe Glu Leu Tyr  Leu Glu Pro 

    1115                 1120                 1125             





Leu Gln  Asn Glu Thr Phe Leu  Thr Gln Asp Glu Met  Glu Ser Leu 

    1130                 1135                 1140             





Phe Gly  Ser Leu Pro Glu Met  Leu Glu Phe Gln Lys  Val Phe Leu 

    1145                 1150                 1155             





Glu Thr  Leu Glu Asp Gly Ile  Ser Ala Ser Ser Asp  Phe Asn Thr 

    1160                 1165                 1170             





Leu Glu  Thr Pro Ser Gln Phe  Arg Lys Leu Leu Phe  Ser Leu Gly 

    1175                 1180                 1185             





Gly Ser  Phe Leu Tyr Tyr Ala  Asp His Phe Lys Leu  Tyr Ser Gly 

    1190                 1195                 1200             





Phe Cys  Ala Asn His Ile Lys  Val Gln Lys Val Leu  Glu Arg Ala 

    1205                 1210                 1215             





Lys Thr  Asp Lys Ala Phe Lys  Ala Phe Leu Asp Ala  Arg Asn Pro 

    1220                 1225                 1230             





Thr Lys  Gln His Ser Ser Thr  Leu Glu Ser Tyr Leu  Ile Lys Pro 

    1235                 1240                 1245             





Val Gln  Arg Val Leu Lys Tyr  Pro Leu Leu Leu Lys  Glu Leu Val 

    1250                 1255                 1260             





Ser Leu  Thr Asp Gln Glu Ser  Glu Glu His Tyr His  Leu Thr Glu 

    1265                 1270                 1275             





Ala Leu  Lys Ala Met Glu Lys  Val Ala Ser His Ile  Asn Glu Met 

    1280                 1285                 1290             





Gln Lys  Ile Tyr Glu Asp Tyr  Gly Thr Val Phe Asp  Gln Leu Val 

    1295                 1300                 1305             





Ala Glu  Gln Ser Gly Thr Glu  Lys Glu Val Thr Glu  Leu Ser Met 

    1310                 1315                 1320             





Gly Glu  Leu Leu Met His Ser  Thr Val Ser Trp Leu  Asn Pro Phe 

    1325                 1330                 1335             





Leu Ser  Leu Gly Lys Ala Arg  Lys Asp Leu Glu Leu  Thr Val Phe 

    1340                 1345                 1350             





Val Phe  Lys Arg Ala Val Ile  Leu Val Tyr Lys Glu  Asn Cys Lys 

    1355                 1360                 1365             





Leu Lys  Lys Lys Leu Pro Ser  Asn Ser Arg Pro Ala  His Asn Ser 

    1370                 1375                 1380             





Thr Asp  Leu Asp Pro Phe Lys  Phe Arg Trp Leu Ile  Pro Ile Ser 

    1385                 1390                 1395             





Ala Leu  Gln Val Arg Leu Gly  Asn Pro Ala Gly Thr  Glu Asn Asn 

    1400                 1405                 1410             





Ser Ile  Trp Glu Leu Ile His  Thr Lys Ser Glu Ile  Glu Gly Arg 

    1415                 1420                 1425             





Pro Glu  Thr Ile Phe Gln Leu  Cys Cys Ser Asp Ser  Glu Ser Lys 

    1430                 1435                 1440             





Thr Asn  Ile Val Lys Val Ile  Arg Ser Ile Leu Arg  Glu Asn Phe 

    1445                 1450                 1455             





Arg Arg  His Ile Lys Cys Glu  Leu Pro Leu Glu Lys  Thr Cys Lys 

    1460                 1465                 1470             





Asp Arg  Leu Val Pro Leu Lys  Asn Arg Val Pro Val  Ser Ala Lys 

    1475                 1480                 1485             





Leu Ala  Ser Ser Arg Ser Leu  Lys Val Leu Lys Asn  Ser Ser Ser 

    1490                 1495                 1500             





Asn Glu  Trp Thr Gly Glu Thr  Gly Lys Gly Thr Leu  Leu Asp Ser 

    1505                 1510                 1515             





Asp Glu  Gly Ser Leu Ser Ser  Gly Thr Gln Ser Ser  Gly Cys Pro 

    1520                 1525                 1530             





Thr Ala  Glu Gly Arg Gln Asp  Ser Lys Ser Thr Ser  Pro Gly Lys 

    1535                 1540                 1545             





Tyr Pro  His Pro Gly Leu Ala  Asp Phe Ala Asp Asn  Leu Ile Lys 

    1550                 1555                 1560             





Glu Ser  Asp Ile Leu Ser Asp  Glu Asp Asp Asp His  Arg Gln Thr 

    1565                 1570                 1575             





Val Lys  Gln Gly Ser Pro Thr  Lys Asp Ile Glu Ile  Gln Phe Gln 

    1580                 1585                 1590             





Arg Leu  Arg Ile Ser Glu Asp  Pro Asp Val His Pro  Glu Ala Glu 

    1595                 1600                 1605             





Gln Gln  Pro Gly Pro Glu Ser  Gly Glu Gly Gln Lys  Gly Gly Glu 

    1610                 1615                 1620             





Gln Pro  Lys Leu Val Arg Gly  His Phe Cys Pro Ile  Lys Arg Lys 

    1625                 1630                 1635             





Ala Asn  Ser Thr Lys Arg Asp  Arg Gly Thr Leu Leu  Lys Ala Gln 

    1640                 1645                 1650             





Ile Arg  His Gln Ser Leu Asp  Ser Gln Ser Glu Asn  Ala Thr Ile 

    1655                 1660                 1665             





Asp Leu  Asn Ser Val Leu Glu  Arg Glu Phe Ser Val  Gln Ser Leu 

    1670                 1675                 1680             





Thr Ser  Val Val Ser Glu Glu  Cys Phe Tyr Glu Thr  Glu Ser His 

    1685                 1690                 1695             





Gly Lys  Ser 

    1700     





<210>  318

<211>  2126

<212>  DNA

<213>  Homo sapiens



<400>  318

gcggagctta ggcggcggtg gctgagaagg cagcggggcg gcggcggcgg cggcggcggc       60



ggctgtggag gccgcagtcc gggtcctggc ttcggcctca gccccaccat ggtgacgctt      120



gctgaactgc tggtgcttct ggccgctctc ctggccacgg tctcgggcta tttcgttagc      180



atcgacgccc atgctgaaga gtgcttcttt gagcgggtca cctcgggcac caagatgggc      240



ctcatcttcg aggtggcgga gggcggcttc ctggacatcg acgtggagat tacaggacca      300



gataacaaag gaatttacaa aggagacaga gaatccagtg ggaaatacac atttgctgct      360



cacatggatg gaacatacaa attttgtttt agtaaccgga tgtccaccat gactccaaaa      420



atagtgatgt tcaccattga tattggggag gctccaaaag gacaagatat ggaaacagaa      480



gctcaccaga acaagctaga agaaatgatc aatgagctag cagtggcgat gacagctgta      540



aagcacgaac aggaatacat ggaagtccgg gagagaatac acagagccat caacgacaac      600



acaaacagca gagtggtcct ttggtccttc tttgaagctc ttgttctagt tgccatgaca      660



ttgggacaga tctactacct gaagagattt tttgaagtcc ggagagttgt ttaaaaagcc      720



tcttcctgat gatcccaact cagaattcac tgtttaccaa acaccttggt cataataatg      780



tcattagttt ctccattttt attttctgaa ctgtacattc acaacttatg tttctttgag      840



attaatagat attgggggaa aaacgccttt ttaggaaaat tatagtgaaa atttgacagt      900



tgattggcat aatttcttgt ttgaatgctg cctccattat ataggtcctt ccaggaactc      960



aaacactgta agtgaaatat gggagtatag tttttattat ttcttctttt ccttttgttt     1020



tcataatata atgcagtttg ttcaggaaat cagcacaaag cctgatagta ctttactaaa     1080



atgactgcat tctttggatt ccttcagtct atggttcaag tcactaaaga ttcatttttg     1140



ttgagtcctt atgagaaaca gcagtatgaa tcttgacggt ttctgcccgt cctaatggca     1200



gagctctctg acttgggtgt atgctgccag gctgggtact ttcatacttt gttttcttgt     1260



tttgctttaa aactacgact cagcatacat tttcccacat acatttttac attgtacctt     1320



aggactcagt catctccact taaattgatg acacaagcag ctaataacca tttctgggtt     1380



tctgcctaac cccctaattg tctgttaaag ccaattctct gggtgtccca gtgagtggtg     1440



gctttttttc tttccacatt ggcacattca cttctcccac tcttggcatg taagaaataa     1500



gcatttacat aattggaaaa atctggattt ctgatgccaa agggttaaag cttcttggat     1560



ttcatttcat tgatatacag ccactatttt atttttgatc agtggccttt gggccactgt     1620



tcagggtact gaccatcagt gtcagcatta gggttttggt ttttgtttct tttgggtctt     1680



tcttttttgg cacatgtgaa tcttgttttg tgtaaaatga aattactttc tcttgttctc     1740



tgatgatggg tttaaaatta aaagagcatc cggttttggt atggggatga tccaggatta     1800



tgttgtgact gatacatatt agttacttgt gctttttttt ttttttttgg atctttgcaa     1860



gggcaaaact acaagtaacg agttttatat aattaattta aatttgttac aggttttcat     1920



gttcaggata aaccatactt ccaccttggg tgagaacact tgcaacagtt tattaatgag     1980



gtgactttca ccttaggaca actgttgcat gccaagtttt ttgtgtgtgt gaaacacttc     2040



aaaactgatt taaaagatgt aaatttaaaa ttggttgtat ctaatatgcc ccaggttcgg     2100



taaataaaca attcttttta aaaaca                                          2126





<210>  319

<211>  201

<212>  PRT

<213>  Homo sapiens



<400>  319



Met Val Thr Leu Ala Glu Leu Leu Val Leu Leu Ala Ala Leu Leu Ala 

1               5                   10                  15      





Thr Val Ser Gly Tyr Phe Val Ser Ile Asp Ala His Ala Glu Glu Cys 

            20                  25                  30          





Phe Phe Glu Arg Val Thr Ser Gly Thr Lys Met Gly Leu Ile Phe Glu 

        35                  40                  45              





Val Ala Glu Gly Gly Phe Leu Asp Ile Asp Val Glu Ile Thr Gly Pro 

    50                  55                  60                  





Asp Asn Lys Gly Ile Tyr Lys Gly Asp Arg Glu Ser Ser Gly Lys Tyr 

65                  70                  75                  80  





Thr Phe Ala Ala His Met Asp Gly Thr Tyr Lys Phe Cys Phe Ser Asn 

                85                  90                  95      





Arg Met Ser Thr Met Thr Pro Lys Ile Val Met Phe Thr Ile Asp Ile 

            100                 105                 110         





Gly Glu Ala Pro Lys Gly Gln Asp Met Glu Thr Glu Ala His Gln Asn 

        115                 120                 125             





Lys Leu Glu Glu Met Ile Asn Glu Leu Ala Val Ala Met Thr Ala Val 

    130                 135                 140                 





Lys His Glu Gln Glu Tyr Met Glu Val Arg Glu Arg Ile His Arg Ala 

145                 150                 155                 160 





Ile Asn Asp Asn Thr Asn Ser Arg Val Val Leu Trp Ser Phe Phe Glu 

                165                 170                 175     





Ala Leu Val Leu Val Ala Met Thr Leu Gly Gln Ile Tyr Tyr Leu Lys 

            180                 185                 190         





Arg Phe Phe Glu Val Arg Arg Val Val 

        195                 200     





<210>  320

<211>  1901

<212>  DNA

<213>  Homo sapiens



<400>  320

cgcacttctg actcgagtcc ccgccgcgct tgtcgtcgcc gccgccggga tccgcagccc       60



cgcgccatgg agccggccgc gggcatccag cgccgcagct cccaggggcc caccgtcccg      120



ccgccgcccc ggggccacgc gccaccggct gccgcccccg gcccggcccc gctgagctcc      180



ccggtgcgcg agccgcccca gctggaggag gagcggcagg tgcggatcag cgagagcggc      240



cagttcagcg acgggctgga ggaccgaggc ttactagaaa gcagcacccg cctgaaacct      300



cacgaagccc agaactacag gaagaaggca ttgtgggtgt cctggttctc catcattgtc      360



accctggccc tcgcggtggc tgcctttact gtctccgtta tgaggtacag cgcctctgct      420



tttgggtttg catttgatgc catcctggac gtcctgtcat cggcgattgt cctgtggcgt      480



tacagcaacg cggccgctgt gcactctgcc catagggagt acatagcctg tgtcatcttg      540



ggggtgatat tccttctgtc atccatatgt atagtggtca aagccatcca tgacctctca      600



actaggctgc tcccagaagt ggacgatttc ctgttcagtg tctccatttt aagtgggatt      660



ctttgcagca tcctggccgt gttgaagttc atgctgggga aggttctgac cagtagagca      720



ctcataacag atgggtttaa ctccctcgtg ggtggcgtga tgggcttctc cattcttctg      780



agcgcggaag tgttcaagca tgactcggcg gtctggtacc tggacggcag cataggcgtt      840



ctgatcggcc tcaccatatt tgcctatggg gtcaaactcc tcatcgacat ggtgccgagg      900



gtgaggcaga cacgtcacta cgagatgttt gagtgaaggg ggccagcatc cgcatgagac      960



catcgagatg aggagtttcc acataggcaa agggtgccaa tatttaactg aacatctggt     1020



ttctttttgg aagttttctt tcacatggtt tgtcattaca agacaaggtc tgcccagcca     1080



ggtggatcta ccttgccccc atcacctgcc gcccccatca aacatgttgg gacaatgccc     1140



ataggaatgg acctccttcc ccgtctccag ctgggactgg cgttttttag tctctggagt     1200



atgatggttc tcatgggtag gatgagatct ttggcagaaa ggtcttcggt ggtgctctga     1260



gcctgcgctg cataggactg agcagaccca cctcctccag cttgggtggc cctgccactc     1320



ctggttccaa gtctctcctt tcctggcagg tcttaaggga agattgtacc cctcaccctt     1380



tacataccca gaatcatcag tatgtcactt cctaatttct atcagtgtat ctcattattt     1440



catactgttt tactaatcct aagtctaaac agatttgctc aaaaggagac cattctattt     1500



tttaaagtac ttagtgatac acgtataagc tttgcatgga cgaattaaat aagcacattg     1560



accttttctt gtacattcag aacctgaaca tccatgtgaa aactgggtcc atttttgaga     1620



gatgtgaaac tacagtttat ttgtaataaa taaatataat ctatccgtat atgcatatat     1680



ctatatgctg tgttaagtgg taatgggtac attacagtct gtgagagatg gatcgctccc     1740



tctgtaagga acaagacgtt ctcagctgat gtcacggtag gtttagattc tgtagagtgt     1800



tccccaaccc gcaccgttct gtacctctca caccactgct tgcccgggca gtagtggctg     1860



accaataaag acctttacct gttttgtatg gcaaaaaaaa a                         1901





<210>  321

<211>  289

<212>  PRT

<213>  Homo sapiens



<400>  321



Met Glu Pro Ala Ala Gly Ile Gln Arg Arg Ser Ser Gln Gly Pro Thr 

1               5                   10                  15      





Val Pro Pro Pro Pro Arg Gly His Ala Pro Pro Ala Ala Ala Pro Gly 

            20                  25                  30          





Pro Ala Pro Leu Ser Ser Pro Val Arg Glu Pro Pro Gln Leu Glu Glu 

        35                  40                  45              





Glu Arg Gln Val Arg Ile Ser Glu Ser Gly Gln Phe Ser Asp Gly Leu 

    50                  55                  60                  





Glu Asp Arg Gly Leu Leu Glu Ser Ser Thr Arg Leu Lys Pro His Glu 

65                  70                  75                  80  





Ala Gln Asn Tyr Arg Lys Lys Ala Leu Trp Val Ser Trp Phe Ser Ile 

                85                  90                  95      





Ile Val Thr Leu Ala Leu Ala Val Ala Ala Phe Thr Val Ser Val Met 

            100                 105                 110         





Arg Tyr Ser Ala Ser Ala Phe Gly Phe Ala Phe Asp Ala Ile Leu Asp 

        115                 120                 125             





Val Leu Ser Ser Ala Ile Val Leu Trp Arg Tyr Ser Asn Ala Ala Ala 

    130                 135                 140                 





Val His Ser Ala His Arg Glu Tyr Ile Ala Cys Val Ile Leu Gly Val 

145                 150                 155                 160 





Ile Phe Leu Leu Ser Ser Ile Cys Ile Val Val Lys Ala Ile His Asp 

                165                 170                 175     





Leu Ser Thr Arg Leu Leu Pro Glu Val Asp Asp Phe Leu Phe Ser Val 

            180                 185                 190         





Ser Ile Leu Ser Gly Ile Leu Cys Ser Ile Leu Ala Val Leu Lys Phe 

        195                 200                 205             





Met Leu Gly Lys Val Leu Thr Ser Arg Ala Leu Ile Thr Asp Gly Phe 

    210                 215                 220                 





Asn Ser Leu Val Gly Gly Val Met Gly Phe Ser Ile Leu Leu Ser Ala 

225                 230                 235                 240 





Glu Val Phe Lys His Asp Ser Ala Val Trp Tyr Leu Asp Gly Ser Ile 

                245                 250                 255     





Gly Val Leu Ile Gly Leu Thr Ile Phe Ala Tyr Gly Val Lys Leu Leu 

            260                 265                 270         





Ile Asp Met Val Pro Arg Val Arg Gln Thr Arg His Tyr Glu Met Phe 

        275                 280                 285             





Glu 

    





<210>  322

<211>  8821

<212>  DNA

<213>  Homo sapiens



<400>  322

agatagaaaa agtagtttgc ttggcatctc ccaaattatc ttgagcaaac aataaaataa       60



gaaatgtttc agaagacaat tcggctccca ggcccaaacc aaaactcgaa cctggtactt      120



tttgtaagtg cgggccaaga aaggggctgt aaagttaaag agccggtggc gcctctgaac      180



acacccgggc agggcgagca ggatgtcctt gtccagggag accccttctc ctggctttga      240



ggaaggtgct ccctatcccc gcgggttcct ccgccaagcg ggacgccgcg ccgggcgggt      300



gagagaaagc ccgggcagga gagcacagag ccggcgactg gacgcgagcg cggggcgggt      360



ggagagcgtc tctccgggcg ccgctgctgt tgtcccgggt gctgaaaagc cgggaacttc      420



ccgggaagca gcggcacttt tctccctgga aggctaaaca tatttttgac tggtatgaac      480



ccattctact ttcatgcagt aaatataatt ttacactgct tagtgactct tgtgctgatg      540



tacacctgtg ataaaactgt cttcaagaat cgtggacttg cttttgtaac ggcattgctt      600



tttgctgtac atcctattca tactgaggcg gtggctggga tcgttggcag agcggacgtg      660



ttagcgtgtc tgctgtttct attggccttt ctctcgtaca acaggagtct ggatcagggc      720



tgtgttgggg gaagtttccc ttccacggtg tctcccttct tcttgctgct cagtttgttt      780



ctggggacct gtgcgatgct ggtgaaagag acaggcatca cggtgtttgg agtgtgcttg      840



gtttatgacc tcttttccct ttccaacaag caagacaagt cgagcaatgg ggccctctgt      900



ccacgcagcc cacagcagcc cgggagcccc cagccctcct cactgccagg ccatcctcac      960



cgggagaatg ggaagcagca gcggttccct cacaaaggag cttggggtgg ctgccactct     1020



ccactgccac cagaacccaa gagcagtgga ttcccagtgt ccccacgagc tgtgtggtcc     1080



atgatgagat tcctcaccta ttcctacctc ttggccttca atgtgtggct tctgcttgca     1140



cccgtgaccc tgtgctatga ctggcaggtc ggcagtattc ctctggtaga gaccatatgg     1200



gacatgcgga acttagccac catctttctg gcggttgtga tggccttatt gagcctgcac     1260



tgcttagcag cctttaagag actggagcac aaggaggttt tagtcggctt gttgttcctg     1320



gtgttcccgt tcattccagc cagcaacctc ttcttcaggg tgggttttgt ggtggcggag     1380



agagtccttt acatgcctag catgggctac tgcatccttt ttgtgcatgg actgagcaag     1440



ctctgcactt ggctgaatcg atgtggggcc accaccctga ttgtgtccac tgtgttgctg     1500



ctgttgcttt tctcttggaa aactgtgaaa cagaatgaaa tttggctgtc aagagagtcc     1560



ctattcaggt ctggagttca aactctgccc cacaatgcca aggttcacta caactatgcc     1620



aatttcctga aggaccaagg tcggaacaag gaagcgatct accactacag aacagctctc     1680



aagttgtatc cacgccatgc aagtgcgctc aacaaccttg gaacactgac gagagacaca     1740



gcagaggcaa agatgtacta tcagagggct ctccagctcc atccacagca taaccgggct     1800



cttttcaatc tggggaatct cctcaagtcc caggagaaaa aggaagaagc tatcacctta     1860



ctgaaggatt ccatcaaata tggtccagag tttgcagatg catattcaag cttagcttcg     1920



ttattggctg agcaggagcg gtttaaagaa gctgaagaaa tataccaaac tggaataaag     1980



aactgtccag acagctcaga tttacacaac aactatgggg ttttcttagt tgatactggc     2040



ttaccagaaa aggcagtggc ccattaccag caggccatca aacttagccc cagtcatcac     2100



gtggccatgg tgaacttggg aagactctac aggtcactgg gagagaacag catggctgaa     2160



gaatggtaca agcgcgccct gcaggtggca cacaaagctg agatattgtc acctttggga     2220



gcactgtatt acaacactgg ccgatacgaa gaggctttgc agatttacca ggaagctgca     2280



gcacttcagc cttctcagag ggagctccgc ttggcactgg ctcaggtttt ggccgtgatg     2340



ggtcagacaa aagaagctga aaagatgacc aatcacattg tgtcagagga gaccggatgc     2400



cttgaatgct atcgcctctt gtcagccatc tatagcaagc aggagaacca cgacaaggca     2460



cttgatgcta tagacaaggc tctccagctg aaaccaaagg acccaaaagt catttctgaa     2520



ctttttttca caaaaggaaa ccaattaaga gagcagaacc ttctcgacaa agcttttgag     2580



agctatagag tggctgtgca actaaaccca gaccaagcac aggcctggat gaacatgggt     2640



ggcatccaac acatcaaggg aaaatatgtg tctgcaagag cttattatga gagagcctta     2700



cagctggttc cagacagcaa actgctgaag gaaaatcttg ccaaattgga tcgcctagaa     2760



aaacgattac aagaagttcg agaaaaggat caaacatagc accaccgtct gacccaacct     2820



cataggataa tgtggtgcct ctgaaagggg agtgatggaa gccttgcttt cacatcagca     2880



ggggcacaac taatgagatt ttctctcatt ccgagttcag ggtgacacat tttgggacat     2940



ctgctggtag cccagtgctg aaggacttgc ttttccatga agaagacgaa aacagcaaac     3000



aagggcaaga aggtctgaga gggaaggaga atgacattta cacattttac agatttttgt     3060



ttggtttaac tccagatttc tcttgatata tctctgtgct tttgagacct ggagatctaa     3120



ttctgtttag acattttttg tcccagaaat acagaagctt gaaatgctat gaaggcagag     3180



cttctattct ttatgggatg aaatatttca aaagaggata aatcctctgt ggtaagccat     3240



ttggaaaatc ctaccaagaa ttggcttatt taattttcca gaaccaggaa tgagtatcta     3300



atagcttttg tagaaccttc cagaatatgt ggggaaaaag ggctattgct aagtgagctt     3360



tatctaatat cctcctaaga gttttactag tgcttttttg aggaattaca gggaagctcc     3420



tggaattgta catggatatc tttatcccta gggggaaatc aaggagctgg gcacccctaa     3480



ttctttatgg aagtgtttaa aactatttta attttattac aagtattact agagtggtgg     3540



ttctactcta agatttcaaa agtgcattta aaatcataca tgttcccgcc tgcaaatata     3600



ttgttatttt ggtggagaaa aaaatagtat attctacata aaaaattaaa gatattaact     3660



aagagaaatg tcctacttta ttatcttaat gttcagacat catgagattt attatttttt     3720



tgaaaaatat attgaaccat tgaggaacct ttatgatgta tcacagaaat cttcatagat     3780



tctaactaga tggaaaaaga gctctattta tttgtgttcc taggcttaat gagaattctg     3840



ggcttagaac atcaacgatt aatacccaga attctttgtt ttgagaatat tatggagaat     3900



gctctaaaaa tctagggtaa agatctaaat tcaaatttta aatatatatt tatatttaag     3960



aaataggaaa ggcaaagttg aactcacaat ttgacattta tttttagtgt tatttatttc     4020



ataacttata aaatatttaa tatatacata cacactcttc ttttttctct gtacaaagtg     4080



gttttaatat cagctttcaa aactgatctt ataaaatgta aatctaaatt gtaaaatagt     4140



taagttttaa cagtccctcc caaactttgt gttgattatt cacttgctaa agagatgtga     4200



ggaatcagcc ttcagttttt tggcagtagt atattttgga agtgaagaaa ttggaacacc     4260



tgtttctaat ttggtcttca tcattagaga caaaaccaaa acactccagg cagtactgtt     4320



tatagtgctg agccaggtag cacacagaca tagtagccta aaggctcaca taattcgcat     4380



gctcaggcca gggcagggta aaaatagcct tctgcttctt tcaacccagt atcaggaagc     4440



actaccccag tgttattatt tgttttgtca aggtaagtct aaataaacaa gaaaaacttc     4500



ttcggaaggc atggcgaagg gagtatttta aatgaaaatg attacagaat ttgaattagc     4560



atgcatctct ttgtgtgcaa cagtaatcca agaatgtata tgttaccact acaaccattt     4620



gtttctaata gttttttcat gttatataac ataaatgtat ccacaacctt aattaagaac     4680



tattcttccc ccaaaatcat agtcctagtg tcaagaaaca tactccagtg tttattgtaa     4740



aataacaacc acaccctcaa attgaaaaaa gtgaatgtct aggactttat tacaactttt     4800



cagaataatc tgtaatgaaa actcatgctt aaaaatttaa tggaaaagac tgagccccaa     4860



attttgaata gtgattacgc cttacttgaa gtgctaataa aggtaggaga gtacatttgt     4920



tggaataaca gaaatggtga tttcagccta aaagtttctg agggtaaagg atcacatgac     4980



cttcaggaaa ctctctgcct cctgtaggtg ctttcctatc tcccccatcc ttccctaccc     5040



cttttccctt ttccttcctc tctttttctc tcactgtcac tctgtctaca cacactggca     5100



tcttttgaac actaaaagta agcactgttt tttaaaaaag taattatttg ttggatcaga     5160



tacttttatc ccaagtgaat accttcactg agatgtggcc aatgcaatag tttcacagta     5220



aaaacagtgc ctataagaaa atagatcaca tactattttt caatgatatt aagtgtattt     5280



tgtaactatt ttcatttggt ccttgtaaca tgaaataata catggaactt acctttataa     5340



taaaaatgga gtgccctggt tcatcataga ggtgcatcta gtttgccctt aatggaagta     5400



tacttgctgt gtggattgat agcaccttct tgaaatggag gagctcagct ggcctcatgg     5460



atgtgcaatt tttgcagtcc cacagggcct tgcatacaga agcaccccga gctcagttga     5520



atgtctgttt gattttttct tatttatttt tttgagacac agttccactt tgtctttttg     5580



tcacccagga tggagttcag tggcacaaac atggctcact gtagcctcga cctccctggc     5640



tgaagggatc ctcccacctc agcctcccaa gtaaccgaga ctacaggcat atgccagcat     5700



gtccagctaa tttttgtatt ttttgtagag acagggtttc accatgttgc ccaggctggt     5760



ctcaaactcc tgggctcaag cgatctgccc acctctgcct cccaaagtgc tgggattaaa     5820



ggcataagcc accatgtcca actgaaattc ttaataatta ataatttttg agcaagaggt     5880



ccacactttc attttgcact gggttcccaa acaggtcctg ggtaggaagg atggctgagg     5940



ataaaacagg agttgctttg gcctggctga acatttgaac caatgatcag agtttcattt     6000



tatgattgtg ttactctgaa cagatttgct atttttttcc agctacattt agagttcctc     6060



atgtatatat cacccctctt tttccagtcc atctaacctc tccttttttt tgtgcctaga     6120



atcagttctc cttgccttca aaatccctga taagtgtcca tttctttttg tatcctttga     6180



tgtagaagcc acaagaatgg ctttagcagc ttattttaat cttatgaatt attcattcag     6240



gattttttaa atgattcaga tgctttcaat ctgttaacag tatttataaa acatgtttca     6300



gtgatacaac ataggtgaac taaaccaaag atgcaaatgc cttggaggaa aagaaattgt     6360



attatagaga atcctgagat atatcctttt gggttgttta atttaaagcc tatcacaaaa     6420



caaagagaat tgtcgcactt taattccaac ctcctgcagt acttcacaac ccttagcata     6480



agattctgaa atttgtaata ggtggtacct agtttgatgc agggttttgc agcagttgtg     6540



cgaatgcctc tgcgcaacgg cctttcagtc agactaaatg agaaaatcca aactgtccta     6600



tcaaaactga cccacaataa ctgtactctg aggcgaaaca gagcaaatgt gggtttcctg     6660



ttttcattgt aaaacattcc aggttctcag attgaagagc tacattcagc tgatagttga     6720



catctgttcc ctcacacgta gtggctctca acacgggctg cactttggaa tcacctgagg     6780



acctttcgga atcttcggtt gaatcatcct ggctgtcctg gtgatgcttc ttatgtgcag     6840



ctaggctgga gaaccactac agggctgaca cctggaatgg gagcttgtaa cttttacaaa     6900



ataatagatg tttatcatct tttgcaattt ttacttttaa gtctatacta aaatgagcca     6960



aagaagtctt aacaatgatg tatggcacaa ttggttggtt gaggctatca ttccatgatt     7020



acaaataggt ggttatgtgg ggtggttttg cacttgtggc aattggactg caatttggcc     7080



ttaaaatgac acaattcctc gttctcagat ggagaggaat tgccttgaaa tttgcatgta     7140



ccagactaag tgccagtata tatatgactg atattttcgt gactcataga aggtgtccat     7200



ggtatagagt ttatgcctac atctctatct ttattttggg cacacatgag cttttgttaa     7260



ttatttcttt gtacttgtta gaatctgttt ttgaaaaaaa aaaaaacttt tgctttgatt     7320



tgtggtggat tcaccttctt aaaataataa atttagagga tattaggaat gacattcaaa     7380



acaaatatag tgagaggtga ttttttaaaa atttttgttc ctggtttcca aattatgttt     7440



actttgattt gattatatgt tggtatctcc caaatatagg ttaacttagc tatttaaatg     7500



gtatcttttg acatttaaaa agaattaagt acctgtcaaa tctagcattg aggttgcagt     7560



tgaataagat aaaagcttag gatgtcaaaa aataatatag agaaatatta taagatttta     7620



tgattattct tgacgttttt gatgcaaaag gaaaatatgc tgaatagttc ttccaaaaaa     7680



tattatttcc ctcaatattt tatttgtagc catgtaattt aaagagaaca gaaaataact     7740



gcaatcaaaa gtatggttta atatcaatca aagtggcaca acagaattga taagatcttt     7800



ataacaatca attggctgat attaaaatat tgattttaat tgatcttttc aattaaaatc     7860



tttagggcct gtaactcata aaatcagcat ccaccacaat atatggtcat tattggtttg     7920



taagcataga tcaccattga ctcctacctg gagagacatg tctatttcta aaaatccagt     7980



agtttctttg cattctcagt agtacacgtt gtatatatat atatgtaaca aatttggtag     8040



ttttcagtat gtgtgatgtc ctttgggggt tatttatctt gctggtccat aggaggggta     8100



cactacccca agaatcaaga catctgagtt ctagttctag ttctagctct gccactgaag     8160



agccacctta cctggggcaa gttagccatt gtctcccagt catgtttacc acccatgaaa     8220



ggactcgtcg gtttgatgtt tccattaagc tcaatgagta actctaatag ttactcttga     8280



atctggattg aaaaacacca tgcatctgat gagataattc ataaatgttg cccctttttt     8340



aaatgataca accctaaaag tgactgaatt gcccaagtgc ttgaacatgg cagaggtagt     8400



tactcctatt ttgcagtttg tgcacttaaa aattcctaca gtgattgtta ctttactggg     8460



gaaaaaagat gaggtgaaac ttcctcccaa ggaattaaaa tatctgtaga agccatggct     8520



tgcttttata atgtggaaat catttgattt gctgtaattc acgcagatcc ctccttttgt     8580



cagggggaaa tgatttgcat catgttcttt tttcataatg cttttacttc ctgtttggat     8640



cagttgtatg taaatgtaca tttttgttac tttggctgtg cccgttagaa tttatcttcc     8700



ataaagtatt tctcccattg agtctaatga tgtatacttt gcctaggtct ttccaaaatt     8760



aaatttatgt aaatgtctat tttatataaa atatgattaa aataagtatg tctggtttca     8820



a                                                                     8821





<210>  323

<211>  774

<212>  PRT

<213>  Homo sapiens



<400>  323



Met Asn Pro Phe Tyr Phe His Ala Val Asn Ile Ile Leu His Cys Leu 

1               5                   10                  15      





Val Thr Leu Val Leu Met Tyr Thr Cys Asp Lys Thr Val Phe Lys Asn 

            20                  25                  30          





Arg Gly Leu Ala Phe Val Thr Ala Leu Leu Phe Ala Val His Pro Ile 

        35                  40                  45              





His Thr Glu Ala Val Ala Gly Ile Val Gly Arg Ala Asp Val Leu Ala 

    50                  55                  60                  





Cys Leu Leu Phe Leu Leu Ala Phe Leu Ser Tyr Asn Arg Ser Leu Asp 

65                  70                  75                  80  





Gln Gly Cys Val Gly Gly Ser Phe Pro Ser Thr Val Ser Pro Phe Phe 

                85                  90                  95      





Leu Leu Leu Ser Leu Phe Leu Gly Thr Cys Ala Met Leu Val Lys Glu 

            100                 105                 110         





Thr Gly Ile Thr Val Phe Gly Val Cys Leu Val Tyr Asp Leu Phe Ser 

        115                 120                 125             





Leu Ser Asn Lys Gln Asp Lys Ser Ser Asn Gly Ala Leu Cys Pro Arg 

    130                 135                 140                 





Ser Pro Gln Gln Pro Gly Ser Pro Gln Pro Ser Ser Leu Pro Gly His 

145                 150                 155                 160 





Pro His Arg Glu Asn Gly Lys Gln Gln Arg Phe Pro His Lys Gly Ala 

                165                 170                 175     





Trp Gly Gly Cys His Ser Pro Leu Pro Pro Glu Pro Lys Ser Ser Gly 

            180                 185                 190         





Phe Pro Val Ser Pro Arg Ala Val Trp Ser Met Met Arg Phe Leu Thr 

        195                 200                 205             





Tyr Ser Tyr Leu Leu Ala Phe Asn Val Trp Leu Leu Leu Ala Pro Val 

    210                 215                 220                 





Thr Leu Cys Tyr Asp Trp Gln Val Gly Ser Ile Pro Leu Val Glu Thr 

225                 230                 235                 240 





Ile Trp Asp Met Arg Asn Leu Ala Thr Ile Phe Leu Ala Val Val Met 

                245                 250                 255     





Ala Leu Leu Ser Leu His Cys Leu Ala Ala Phe Lys Arg Leu Glu His 

            260                 265                 270         





Lys Glu Val Leu Val Gly Leu Leu Phe Leu Val Phe Pro Phe Ile Pro 

        275                 280                 285             





Ala Ser Asn Leu Phe Phe Arg Val Gly Phe Val Val Ala Glu Arg Val 

    290                 295                 300                 





Leu Tyr Met Pro Ser Met Gly Tyr Cys Ile Leu Phe Val His Gly Leu 

305                 310                 315                 320 





Ser Lys Leu Cys Thr Trp Leu Asn Arg Cys Gly Ala Thr Thr Leu Ile 

                325                 330                 335     





Val Ser Thr Val Leu Leu Leu Leu Leu Phe Ser Trp Lys Thr Val Lys 

            340                 345                 350         





Gln Asn Glu Ile Trp Leu Ser Arg Glu Ser Leu Phe Arg Ser Gly Val 

        355                 360                 365             





Gln Thr Leu Pro His Asn Ala Lys Val His Tyr Asn Tyr Ala Asn Phe 

    370                 375                 380                 





Leu Lys Asp Gln Gly Arg Asn Lys Glu Ala Ile Tyr His Tyr Arg Thr 

385                 390                 395                 400 





Ala Leu Lys Leu Tyr Pro Arg His Ala Ser Ala Leu Asn Asn Leu Gly 

                405                 410                 415     





Thr Leu Thr Arg Asp Thr Ala Glu Ala Lys Met Tyr Tyr Gln Arg Ala 

            420                 425                 430         





Leu Gln Leu His Pro Gln His Asn Arg Ala Leu Phe Asn Leu Gly Asn 

        435                 440                 445             





Leu Leu Lys Ser Gln Glu Lys Lys Glu Glu Ala Ile Thr Leu Leu Lys 

    450                 455                 460                 





Asp Ser Ile Lys Tyr Gly Pro Glu Phe Ala Asp Ala Tyr Ser Ser Leu 

465                 470                 475                 480 





Ala Ser Leu Leu Ala Glu Gln Glu Arg Phe Lys Glu Ala Glu Glu Ile 

                485                 490                 495     





Tyr Gln Thr Gly Ile Lys Asn Cys Pro Asp Ser Ser Asp Leu His Asn 

            500                 505                 510         





Asn Tyr Gly Val Phe Leu Val Asp Thr Gly Leu Pro Glu Lys Ala Val 

        515                 520                 525             





Ala His Tyr Gln Gln Ala Ile Lys Leu Ser Pro Ser His His Val Ala 

    530                 535                 540                 





Met Val Asn Leu Gly Arg Leu Tyr Arg Ser Leu Gly Glu Asn Ser Met 

545                 550                 555                 560 





Ala Glu Glu Trp Tyr Lys Arg Ala Leu Gln Val Ala His Lys Ala Glu 

                565                 570                 575     





Ile Leu Ser Pro Leu Gly Ala Leu Tyr Tyr Asn Thr Gly Arg Tyr Glu 

            580                 585                 590         





Glu Ala Leu Gln Ile Tyr Gln Glu Ala Ala Ala Leu Gln Pro Ser Gln 

        595                 600                 605             





Arg Glu Leu Arg Leu Ala Leu Ala Gln Val Leu Ala Val Met Gly Gln 

    610                 615                 620                 





Thr Lys Glu Ala Glu Lys Met Thr Asn His Ile Val Ser Glu Glu Thr 

625                 630                 635                 640 





Gly Cys Leu Glu Cys Tyr Arg Leu Leu Ser Ala Ile Tyr Ser Lys Gln 

                645                 650                 655     





Glu Asn His Asp Lys Ala Leu Asp Ala Ile Asp Lys Ala Leu Gln Leu 

            660                 665                 670         





Lys Pro Lys Asp Pro Lys Val Ile Ser Glu Leu Phe Phe Thr Lys Gly 

        675                 680                 685             





Asn Gln Leu Arg Glu Gln Asn Leu Leu Asp Lys Ala Phe Glu Ser Tyr 

    690                 695                 700                 





Arg Val Ala Val Gln Leu Asn Pro Asp Gln Ala Gln Ala Trp Met Asn 

705                 710                 715                 720 





Met Gly Gly Ile Gln His Ile Lys Gly Lys Tyr Val Ser Ala Arg Ala 

                725                 730                 735     





Tyr Tyr Glu Arg Ala Leu Gln Leu Val Pro Asp Ser Lys Leu Leu Lys 

            740                 745                 750         





Glu Asn Leu Ala Lys Leu Asp Arg Leu Glu Lys Arg Leu Gln Glu Val 

        755                 760                 765             





Arg Glu Lys Asp Gln Thr 

    770                 





<210>  324

<211>  3669

<212>  DNA

<213>  Homo sapiens



<400>  324

aaaggtatcg gtgctgtcgc ttccggtccg ggtaaacgaa ccttaggtac actggtgtgt       60



ggcctcccaa gataggcttc tgagggcaag tcagcgactg aagacgggag cgccagaatc      120



tgtggactca agagtctaga atcaagtgga aaaaccggaa aaaaggccag gaacctgaat      180



acgacctaat agctgtttcc gagggggcaa cttccacgga gaaccttctg ccctggtaac      240



ggccaaagag gaggagatgg cgccagtcag ggagcggccg tggcccagac agtgaggaag      300



cgcgaaggcg gagcaaccga ggaatcctcc ggagaagaat cagagccgtc gctaccgcca      360



ctaccgccac caccatggaa ggagcaaagc cgacattgca gctcgtgtac caggcagtgc      420



aggcgcttta ccacgaccca gatcccagcg gaaaggagcg cgcctctttt tggcttgggg      480



agctgcagcg ttcggttcat gcatgggaga tctcagacca gttgttacag atccggcagg      540



atgtggagtc atgctatttt gctgcacaga ccatgaaaat gaagattcag acctcatttt      600



atgagctccc cacagactct catgcctctt tacgggactc attgctaacc catatccaga      660



acttgaaaga cttgtcacct gttattgtaa cgcagctggc tttagcaata gcagatcttg      720



ccctacagat gccttcctgg aagggatgtg tgcaaacact ggtggaaaaa tacagcaatg      780



atgtgacttc tttgcctttt ttgctggaga tccttacagt gttacctgaa gaagtacata      840



gtcgttcctt acgaattgga gctaatcggc gcacagaaat tatagaagat ttggccttct      900



actctagtac agtagtatct ctattgatga cctgtgtaga aaaagcagga acagatgaga      960



aaatgcttat gaaggttttt cgctgtttgg gaagttggtt taacttggga gttttggaca     1020



gtaacttcat ggctaacaat aaattactag cactcctttt tgaggttttg caacaggata     1080



agacctcgtc taacctacat gaagctgctt cggactgtgt atgctcagct ctctatgcca     1140



ttgagaatgt ggagactaac ttgccattag ccatgcaact ttttcaggga gtgctgacat     1200



tggagactgc ctatcatatg gccgtggcac gtgaagattt agacaaagtt ctgaattact     1260



gccgtatttt cactgaacta tgtgaaactt ttcttgaaaa aattgtttgt actccaggcc     1320



aaggtcttgg ggaccttcga actctggagc tgctgcttat ctgtgcaggc catcctcaat     1380



atgaggtagt agaaatttca tttaactttt ggtaccgact gggggaacat ttgtacaaaa     1440



ctaacgatga agttattcat ggcatcttca aagcttacat tcagaggctg cttcacgcct     1500



tggctcgaca ctgccagctg gaaccagacc atgagggggt tcctgaggag actgatgact     1560



ttggggagtt tcgcatgagg gtatcagacc tggtaaagga cttgattttc ttgatagggt     1620



ctatggagtg ttttgctcag ttatattcta ctctgaaaga aggcaaccca ccctgggagg     1680



tgacagaagc ggttctcttt atcatggctg ctatagcaaa gagtgttgat ccggaaaaca     1740



atccaacact tgtggaagtc ctagaaggag ttgtccgcct cccggagacc gtacatacgg     1800



ctgtgcgata caccagcatt gaattggttg gagagatgag tgaagtcgtt gatcgaaatc     1860



ctcagttcct tgaccctgtg ttgggctatt tgatgaaagg cctgtgtgaa aagcccctgg     1920



cttctgctgc agccaaagcc attcataaca tttgctctgt ctgccgagat cacatggctc     1980



agcactttaa tggactcctg gagattgccc gctccctcga ttccttcctg ttgtctccag     2040



aagctgctgt gggcttgcta aaagggacag cacttgtcct agcccgatta cctttggata     2100



agattaccga atgtcttagt gaactatgtt ctgttcaggt tatggcattg aaaaagctgt     2160



tgtctcaaga gcccagcaat ggcatatcct cagatcccac agtgttctta gatcgccttg     2220



cagtgatatt taggcatacc aatcccattg tggaaaatgg acagactcat ccgtgtcaga     2280



aagtcataca ggaaatatgg ccagttttat ccgagactct aaataagcac cgagctgata     2340



atcggattgt agagcgttgt tgcaggtgcc tgcgctttgc tgttcgctgt gtaggcaaag     2400



gatctgcagc actgctgcag ccactagtca cacagatggt gaatgtgtac cacgtacatc     2460



agcattcctg cttcctgtac cttggcagta tccttgtgga tgaatatggc atggaagaag     2520



gctgtcggca gggactgcta gacatgctcc aggcactgtg catccccacc tttcagctcc     2580



tagaacagca gaatggtctc cagaatcacc ctgacactgt agatgacctg ttccggctag     2640



ccaccaggtt tattcagcgt agccctgtca ccttgctgcg gagccaagtg gtcatcccta     2700



tcttacagtg ggccattgcc tctactaccc tggaccaccg ggatgccaat tgtagtgtca     2760



tgaggtttct acgagacctc attcatacag gggtagccaa tgatcatgaa gaagactttg     2820



aattacggaa agaactgatt ggacaggtga tgaaccagct tggacagcag cttgtcagcc     2880



agctgctgca cacctgctgc ttttgcctcc ccccctatac cctaccagat gtggctgaag     2940



tgctctggga gatcatgcag gttgacagac cgactttttg tcgatggtta gaaaattcct     3000



taaaaggttt gccaaaggaa acaaccgtgg gagccgtcac agtgacacac aaacaactta     3060



cagacttcca caagcaagtc actagtgctg aggaatgtaa acaagtttgc tgggccttgc     3120



gagacttcac caggttgttt cgatagctca cactcctgca ctgtgcctgt cacccaggaa     3180



tgtctttttt aattagaaga caggaagaaa acaaaaacca gactgtgtcc cacaatcaga     3240



aacctccgtt gtggcagagg ggccttcacc gccaccaggg tgtcccgcca gacagggaga     3300



gactccagcc ttctgaggcc atcctgagga gttcctgttt gggggtgtga gggaaaatca     3360



gcgcggattt taaaaagatg gctgtggcct gcccggcgtg gtgggagggg agctggtttc     3420



ctggtgaact ttctaaaagg aaaaataatt ttaagtaaag aaaaaagaaa aaaaaggaag     3480



actaaacaga aaccagaact gaaacattca cctggtagca aatgacacat gcacgcacac     3540



acacatacac gcacaagcgc cagtgcgcac gtgtacacag aaaaacaaaa ggacaagctt     3600



tctgtgaaac aaaatattta cttagggata atgtggggat tcacatgaat taaatagctg     3660



caattggaa                                                             3669





<210>  325

<211>  923

<212>  PRT

<213>  Homo sapiens



<400>  325



Met Glu Gly Ala Lys Pro Thr Leu Gln Leu Val Tyr Gln Ala Val Gln 

1               5                   10                  15      





Ala Leu Tyr His Asp Pro Asp Pro Ser Gly Lys Glu Arg Ala Ser Phe 

            20                  25                  30          





Trp Leu Gly Glu Leu Gln Arg Ser Val His Ala Trp Glu Ile Ser Asp 

        35                  40                  45              





Gln Leu Leu Gln Ile Arg Gln Asp Val Glu Ser Cys Tyr Phe Ala Ala 

    50                  55                  60                  





Gln Thr Met Lys Met Lys Ile Gln Thr Ser Phe Tyr Glu Leu Pro Thr 

65                  70                  75                  80  





Asp Ser His Ala Ser Leu Arg Asp Ser Leu Leu Thr His Ile Gln Asn 

                85                  90                  95      





Leu Lys Asp Leu Ser Pro Val Ile Val Thr Gln Leu Ala Leu Ala Ile 

            100                 105                 110         





Ala Asp Leu Ala Leu Gln Met Pro Ser Trp Lys Gly Cys Val Gln Thr 

        115                 120                 125             





Leu Val Glu Lys Tyr Ser Asn Asp Val Thr Ser Leu Pro Phe Leu Leu 

    130                 135                 140                 





Glu Ile Leu Thr Val Leu Pro Glu Glu Val His Ser Arg Ser Leu Arg 

145                 150                 155                 160 





Ile Gly Ala Asn Arg Arg Thr Glu Ile Ile Glu Asp Leu Ala Phe Tyr 

                165                 170                 175     





Ser Ser Thr Val Val Ser Leu Leu Met Thr Cys Val Glu Lys Ala Gly 

            180                 185                 190         





Thr Asp Glu Lys Met Leu Met Lys Val Phe Arg Cys Leu Gly Ser Trp 

        195                 200                 205             





Phe Asn Leu Gly Val Leu Asp Ser Asn Phe Met Ala Asn Asn Lys Leu 

    210                 215                 220                 





Leu Ala Leu Leu Phe Glu Val Leu Gln Gln Asp Lys Thr Ser Ser Asn 

225                 230                 235                 240 





Leu His Glu Ala Ala Ser Asp Cys Val Cys Ser Ala Leu Tyr Ala Ile 

                245                 250                 255     





Glu Asn Val Glu Thr Asn Leu Pro Leu Ala Met Gln Leu Phe Gln Gly 

            260                 265                 270         





Val Leu Thr Leu Glu Thr Ala Tyr His Met Ala Val Ala Arg Glu Asp 

        275                 280                 285             





Leu Asp Lys Val Leu Asn Tyr Cys Arg Ile Phe Thr Glu Leu Cys Glu 

    290                 295                 300                 





Thr Phe Leu Glu Lys Ile Val Cys Thr Pro Gly Gln Gly Leu Gly Asp 

305                 310                 315                 320 





Leu Arg Thr Leu Glu Leu Leu Leu Ile Cys Ala Gly His Pro Gln Tyr 

                325                 330                 335     





Glu Val Val Glu Ile Ser Phe Asn Phe Trp Tyr Arg Leu Gly Glu His 

            340                 345                 350         





Leu Tyr Lys Thr Asn Asp Glu Val Ile His Gly Ile Phe Lys Ala Tyr 

        355                 360                 365             





Ile Gln Arg Leu Leu His Ala Leu Ala Arg His Cys Gln Leu Glu Pro 

    370                 375                 380                 





Asp His Glu Gly Val Pro Glu Glu Thr Asp Asp Phe Gly Glu Phe Arg 

385                 390                 395                 400 





Met Arg Val Ser Asp Leu Val Lys Asp Leu Ile Phe Leu Ile Gly Ser 

                405                 410                 415     





Met Glu Cys Phe Ala Gln Leu Tyr Ser Thr Leu Lys Glu Gly Asn Pro 

            420                 425                 430         





Pro Trp Glu Val Thr Glu Ala Val Leu Phe Ile Met Ala Ala Ile Ala 

        435                 440                 445             





Lys Ser Val Asp Pro Glu Asn Asn Pro Thr Leu Val Glu Val Leu Glu 

    450                 455                 460                 





Gly Val Val Arg Leu Pro Glu Thr Val His Thr Ala Val Arg Tyr Thr 

465                 470                 475                 480 





Ser Ile Glu Leu Val Gly Glu Met Ser Glu Val Val Asp Arg Asn Pro 

                485                 490                 495     





Gln Phe Leu Asp Pro Val Leu Gly Tyr Leu Met Lys Gly Leu Cys Glu 

            500                 505                 510         





Lys Pro Leu Ala Ser Ala Ala Ala Lys Ala Ile His Asn Ile Cys Ser 

        515                 520                 525             





Val Cys Arg Asp His Met Ala Gln His Phe Asn Gly Leu Leu Glu Ile 

    530                 535                 540                 





Ala Arg Ser Leu Asp Ser Phe Leu Leu Ser Pro Glu Ala Ala Val Gly 

545                 550                 555                 560 





Leu Leu Lys Gly Thr Ala Leu Val Leu Ala Arg Leu Pro Leu Asp Lys 

                565                 570                 575     





Ile Thr Glu Cys Leu Ser Glu Leu Cys Ser Val Gln Val Met Ala Leu 

            580                 585                 590         





Lys Lys Leu Leu Ser Gln Glu Pro Ser Asn Gly Ile Ser Ser Asp Pro 

        595                 600                 605             





Thr Val Phe Leu Asp Arg Leu Ala Val Ile Phe Arg His Thr Asn Pro 

    610                 615                 620                 





Ile Val Glu Asn Gly Gln Thr His Pro Cys Gln Lys Val Ile Gln Glu 

625                 630                 635                 640 





Ile Trp Pro Val Leu Ser Glu Thr Leu Asn Lys His Arg Ala Asp Asn 

                645                 650                 655     





Arg Ile Val Glu Arg Cys Cys Arg Cys Leu Arg Phe Ala Val Arg Cys 

            660                 665                 670         





Val Gly Lys Gly Ser Ala Ala Leu Leu Gln Pro Leu Val Thr Gln Met 

        675                 680                 685             





Val Asn Val Tyr His Val His Gln His Ser Cys Phe Leu Tyr Leu Gly 

    690                 695                 700                 





Ser Ile Leu Val Asp Glu Tyr Gly Met Glu Glu Gly Cys Arg Gln Gly 

705                 710                 715                 720 





Leu Leu Asp Met Leu Gln Ala Leu Cys Ile Pro Thr Phe Gln Leu Leu 

                725                 730                 735     





Glu Gln Gln Asn Gly Leu Gln Asn His Pro Asp Thr Val Asp Asp Leu 

            740                 745                 750         





Phe Arg Leu Ala Thr Arg Phe Ile Gln Arg Ser Pro Val Thr Leu Leu 

        755                 760                 765             





Arg Ser Gln Val Val Ile Pro Ile Leu Gln Trp Ala Ile Ala Ser Thr 

    770                 775                 780                 





Thr Leu Asp His Arg Asp Ala Asn Cys Ser Val Met Arg Phe Leu Arg 

785                 790                 795                 800 





Asp Leu Ile His Thr Gly Val Ala Asn Asp His Glu Glu Asp Phe Glu 

                805                 810                 815     





Leu Arg Lys Glu Leu Ile Gly Gln Val Met Asn Gln Leu Gly Gln Gln 

            820                 825                 830         





Leu Val Ser Gln Leu Leu His Thr Cys Cys Phe Cys Leu Pro Pro Tyr 

        835                 840                 845             





Thr Leu Pro Asp Val Ala Glu Val Leu Trp Glu Ile Met Gln Val Asp 

    850                 855                 860                 





Arg Pro Thr Phe Cys Arg Trp Leu Glu Asn Ser Leu Lys Gly Leu Pro 

865                 870                 875                 880 





Lys Glu Thr Thr Val Gly Ala Val Thr Val Thr His Lys Gln Leu Thr 

                885                 890                 895     





Asp Phe His Lys Gln Val Thr Ser Ala Glu Glu Cys Lys Gln Val Cys 

            900                 905                 910         





Trp Ala Leu Arg Asp Phe Thr Arg Leu Phe Arg 

        915                 920             





<210>  326

<211>  777

<212>  DNA

<213>  Homo sapiens



<400>  326

aaggggcgga gctccgtgga aaccggaagt aactcttgac gggcactcgg agcagttccg       60



atgactgtcc acaacctgta cctgtttgac cggaatggag tgtgtctgca ctacagcgaa      120



tggcaccgca agaagcaagc agggattccc aaggaggagg agtataagct gatgtacggg      180



atgctcttct ctatccgctc gtttgtcagc aagatgtccc cgctagacat gaaggatggc      240



ttcctggcct tccaaactag ccgttacaaa ctccattact acgagacgcc cactgggatc      300



aaagttgtca tgaatactga cttgggcgtg ggacccatcc gagatgtgct gcaccacatc      360



tacagtgcgc tgtatgtgga gctggtggtg aagaatcccc tgtgcccgct gggccaaact      420



gtgcaaagtg agctctttcg ctcccgactg gactcctatg ttcgctctct gcccttcttc      480



tccgcccggg ctggctgaag caacctacct caagtctcag gagaattcat gtctgcctgg      540



ggcccttccg aacctgtgcc aactaagggc ccccactgta agcccccgca cccccacccc      600



ctgcccagag caacagccta aaggcctgcc ctgatgctct cctcctacca gagtgaagcc      660



cacagagtcc ctccacctcc acaccaggcc ctctctccag ttttatcccc tgcctaatgc      720



tgcgagaagc acagaataaa ctttttgtca ctctctgcga aaaaaaaaaa aaaaaaa         777





<210>  327

<211>  145

<212>  PRT

<213>  Homo sapiens



<400>  327



Met Thr Val His Asn Leu Tyr Leu Phe Asp Arg Asn Gly Val Cys Leu 

1               5                   10                  15      





His Tyr Ser Glu Trp His Arg Lys Lys Gln Ala Gly Ile Pro Lys Glu 

            20                  25                  30          





Glu Glu Tyr Lys Leu Met Tyr Gly Met Leu Phe Ser Ile Arg Ser Phe 

        35                  40                  45              





Val Ser Lys Met Ser Pro Leu Asp Met Lys Asp Gly Phe Leu Ala Phe 

    50                  55                  60                  





Gln Thr Ser Arg Tyr Lys Leu His Tyr Tyr Glu Thr Pro Thr Gly Ile 

65                  70                  75                  80  





Lys Val Val Met Asn Thr Asp Leu Gly Val Gly Pro Ile Arg Asp Val 

                85                  90                  95      





Leu His His Ile Tyr Ser Ala Leu Tyr Val Glu Leu Val Val Lys Asn 

            100                 105                 110         





Pro Leu Cys Pro Leu Gly Gln Thr Val Gln Ser Glu Leu Phe Arg Ser 

        115                 120                 125             





Arg Leu Asp Ser Tyr Val Arg Ser Leu Pro Phe Phe Ser Ala Arg Ala 

    130                 135                 140                 





Gly 

145 





<210>  328

<211>  837

<212>  DNA

<213>  Homo sapiens



<400>  328

agcagttccg gtgagtccgt gggtggggtc cccacctggt tggaaggctg tgggtccggg       60



aacccgagcc caaggagtgg gggcggcccc ggagcgaggc tcacactccc tgccctgcag      120



atgactgtcc acaacctgta cctgtttgac cggaatggag tgtgtctgca ctacagcgaa      180



tggcaccgca agaagcaagc agggattccc aaggaggagg agtataagct gatgtacggg      240



atgctcttct ctatccgctc gtttgtcagc aagatgtccc cgctagacat gaaggatggc      300



ttcctggcct tccaaactag ccgttacaaa ctccattact acgagacgcc cactgggatc      360



aaagttgtca tgaatactga cttgggcgtg ggacccatcc gagatgtgct gcaccacatc      420



tacagtgcgc tgtatgtgga gctggtggtg aagaatcccc tgtgcccgct gggccaaact      480



gtgcaaagtg agctctttcg ctcccgactg gactcctatg ttcgctctct gcccttcttc      540



tccgcccggg ctggctgaag caacctacct caagtctcag gagaattcat gtctgcctgg      600



ggcccttccg aacctgtgcc aactaagggc ccccactgta agcccccgca cccccacccc      660



ctgcccagag caacagccta aaggcctgcc ctgatgctct cctcctacca gagtgaagcc      720



cacagagtcc ctccacctcc acaccaggcc ctctctccag ttttatcccc tgcctaatgc      780



tgcgagaagc acagaataaa ctttttgtca ctctctgcga aaaaaaaaaa aaaaaaa         837





<210>  329

<211>  145

<212>  PRT

<213>  Homo sapiens



<400>  329



Met Thr Val His Asn Leu Tyr Leu Phe Asp Arg Asn Gly Val Cys Leu 

1               5                   10                  15      





His Tyr Ser Glu Trp His Arg Lys Lys Gln Ala Gly Ile Pro Lys Glu 

            20                  25                  30          





Glu Glu Tyr Lys Leu Met Tyr Gly Met Leu Phe Ser Ile Arg Ser Phe 

        35                  40                  45              





Val Ser Lys Met Ser Pro Leu Asp Met Lys Asp Gly Phe Leu Ala Phe 

    50                  55                  60                  





Gln Thr Ser Arg Tyr Lys Leu His Tyr Tyr Glu Thr Pro Thr Gly Ile 

65                  70                  75                  80  





Lys Val Val Met Asn Thr Asp Leu Gly Val Gly Pro Ile Arg Asp Val 

                85                  90                  95      





Leu His His Ile Tyr Ser Ala Leu Tyr Val Glu Leu Val Val Lys Asn 

            100                 105                 110         





Pro Leu Cys Pro Leu Gly Gln Thr Val Gln Ser Glu Leu Phe Arg Ser 

        115                 120                 125             





Arg Leu Asp Ser Tyr Val Arg Ser Leu Pro Phe Phe Ser Ala Arg Ala 

    130                 135                 140                 





Gly 

145 





<210>  330

<211>  2859

<212>  DNA

<213>  Homo sapiens



<400>  330

tcctgtcact ggcttatatg gacacgtcag cccaccgtca cgtgaccgca ggctgctaaa       60



aacagctcca gcacccactc caaaccaggg cctgaaacaa tgtcctccac cgagagaaac      120



gtaaaggaca cttgatcaca caatccctgg aataatatcc aggaaacact tgctggagcc      180



actcgcagca cccttccctg gcagcacact tggggacagc gaggagatga gcgcatctct      240



gaattacaaa tctttttcca aagagcagca gaccatggat aacttagaga agcaactcat      300



ctgtcccatc tgcttagaga tgttcacgaa acctgtggtg attctccctt gtcagcacaa      360



cctgtgtagg aaatgtgcca gtgatatttt ccaggcctct aacccgtatt tgcccacaag      420



aggaggtacc accatggcat cagggggccg attccgctgc ccatcctgta gacatgaagt      480



ggttttggat agacatgggg tatatggact tcagaggaac ctgctggtgg aaaatatcat      540



tgacatctac aagcaggagt ccaccaggcc agaaaagaaa tccgaccagc ccatgtgcga      600



ggaacatgaa gaggagcgca tcaacatcta ctgtctgaac tgcgaagtac ccacctgctc      660



tctgtgcaag gtgtttggtg cacacaaaga ctgccaggtg gctcccctca ctcatgtgtt      720



ccagagacag aagtctgagc tcagtgatgg catcgccatc ctcgtgggca gcaacgatcg      780



agtccaggga gtgatcagcc agctggaaga cacctgcaaa actatcgagg aatgttgcag      840



aaaacagaaa caagagcttt gtgagaagtt tgattacctg tatggcattt tggaggagag      900



gaagaatgaa atgacccaag tcattacccg aacccaagag gagaaactgg aacatgtccg      960



tgctctgatc aaaaagtatt ctgatcattt ggagaacgtc tcaaagttgg ttgagtcagg     1020



aattcagttt atggatgagc cagaaatggc agtgtttctg cagaatgcca aaaccctgct     1080



aaaaaaaatc tcggaagcat caaaggcatt tcagatggag aaaatagaac atggctatga     1140



gaacatgaac cacttcacag tcaacctcaa tagagaagaa aagataatac gtgaaattga     1200



cttttacaga gaagatgaag atgaagaaga agaagaaggc ggagaaggag aaaaagaagg     1260



agaaggagaa gtgggaggag aagcagtaga agtggaagag gtagaaaatg ttcaaacaga     1320



gtttccagga gaagatgaaa acccagaaaa agcttcagag ctctctcagg tggagctgca     1380



ggctgcccct ggggcacttc cagtttcctc tccagagcca cctccagccc tgccacctgc     1440



tgcggatgcc cctgtgacac agggggaggt tgtacccact ggctctgagc agaccacaga     1500



gtctgaaact ccagtccctg cagcagcaga aactgcggat cccttgtttt accctagttg     1560



gtataaaggc caaacccgga aagccaccac caacccacct tgcaccccag ggagcgaagg     1620



tctggggcaa atagggcctc caggttctga ggattcgaat gtacggaagg cagaagtggc     1680



agcagccgca gcgagtgaga gggcagctgt gagtggtaag gaaactagtg cacctgcagc     1740



tacttctcag gagttagtaa tctgcctagc gcttttggct tttcttattc ttcactacat     1800



ctggagtcag attcagtgct tgatttttac tttaatggat tggatttgag gctcctcccc     1860



tccagggaca ggctgcagct ccagcgagtg gcagtggagc tgattctgag ccagctcgcc     1920



atatcttctc cttttcctgg ttgaactccc taaatgaatg atattcattc caactgctgc     1980



ccctctgtct gcctggctga gatgcatgtg ggcagcagga agcccaagtg aaattaatat     2040



tatgcagatg atgaaaggga cctctgaaca ggatttctgc aaaaatagcc ccaaactgca     2100



attccatatg acttatctaa catcttgggg ggaaagaata ttttgagaaa atagttgcag     2160



aaagcactgg aaataataaa cttgatctta tacaaatctt ctattgtgtg gaaaatgttg     2220



tgaagggtgt gtaggtgtgg tacatgtgta tgtcactaac aagtggcaaa tggtgaaaaa     2280



agtggtcact atgcttttgt ctctcatagg cactgacttt ttgttattat attatggtag     2340



ctttcatttc ctttactctt taacagtgca ggtggtcagt gaaaatcagt gtcaactcag     2400



aagtgactga tttatcaata catggacaaa aagtaaatca ttgaccaaag ctatgaaatg     2460



tttcacaaag ttttcctctt ttgcataaca gatgtcactg gatgtacatt cagaaatgtt     2520



ctttgaattt ggtgacactt tcatggtcca gaaagctgaa ggcctgggca tctcttgtga     2580



catttttcta atattagttt tagattttca cgtattaggc actttagttg aatcttccag     2640



caaaagctgt ctactttctc ttttattcac tgtggcacca atctggtaaa ttgtagaaca     2700



attgcatgtg tttaaatata tatacaaaca tatcacacat taaatatata tatatttaaa     2760



tcatgctttg ttaatatttg tcccaccata atgcctcctt cagaacataa gtgtaacttt     2820



atatgaactc ttaaataaat gatgttttta aaaaaaaaa                            2859





<210>  331

<211>  540

<212>  PRT

<213>  Homo sapiens



<400>  331



Met Ser Ala Ser Leu Asn Tyr Lys Ser Phe Ser Lys Glu Gln Gln Thr 

1               5                   10                  15      





Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 

            20                  25                  30          





Phe Thr Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 

        35                  40                  45              





Lys Cys Ala Ser Asp Ile Phe Gln Ala Ser Asn Pro Tyr Leu Pro Thr 

    50                  55                  60                  





Arg Gly Gly Thr Thr Met Ala Ser Gly Gly Arg Phe Arg Cys Pro Ser 

65                  70                  75                  80  





Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 

                85                  90                  95      





Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 

            100                 105                 110         





Thr Arg Pro Glu Lys Lys Ser Asp Gln Pro Met Cys Glu Glu His Glu 

        115                 120                 125             





Glu Glu Arg Ile Asn Ile Tyr Cys Leu Asn Cys Glu Val Pro Thr Cys 

    130                 135                 140                 





Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Gln Val Ala Pro 

145                 150                 155                 160 





Leu Thr His Val Phe Gln Arg Gln Lys Ser Glu Leu Ser Asp Gly Ile 

                165                 170                 175     





Ala Ile Leu Val Gly Ser Asn Asp Arg Val Gln Gly Val Ile Ser Gln 

            180                 185                 190         





Leu Glu Asp Thr Cys Lys Thr Ile Glu Glu Cys Cys Arg Lys Gln Lys 

        195                 200                 205             





Gln Glu Leu Cys Glu Lys Phe Asp Tyr Leu Tyr Gly Ile Leu Glu Glu 

    210                 215                 220                 





Arg Lys Asn Glu Met Thr Gln Val Ile Thr Arg Thr Gln Glu Glu Lys 

225                 230                 235                 240 





Leu Glu His Val Arg Ala Leu Ile Lys Lys Tyr Ser Asp His Leu Glu 

                245                 250                 255     





Asn Val Ser Lys Leu Val Glu Ser Gly Ile Gln Phe Met Asp Glu Pro 

            260                 265                 270         





Glu Met Ala Val Phe Leu Gln Asn Ala Lys Thr Leu Leu Lys Lys Ile 

        275                 280                 285             





Ser Glu Ala Ser Lys Ala Phe Gln Met Glu Lys Ile Glu His Gly Tyr 

    290                 295                 300                 





Glu Asn Met Asn His Phe Thr Val Asn Leu Asn Arg Glu Glu Lys Ile 

305                 310                 315                 320 





Ile Arg Glu Ile Asp Phe Tyr Arg Glu Asp Glu Asp Glu Glu Glu Glu 

                325                 330                 335     





Glu Gly Gly Glu Gly Glu Lys Glu Gly Glu Gly Glu Val Gly Gly Glu 

            340                 345                 350         





Ala Val Glu Val Glu Glu Val Glu Asn Val Gln Thr Glu Phe Pro Gly 

        355                 360                 365             





Glu Asp Glu Asn Pro Glu Lys Ala Ser Glu Leu Ser Gln Val Glu Leu 

    370                 375                 380                 





Gln Ala Ala Pro Gly Ala Leu Pro Val Ser Ser Pro Glu Pro Pro Pro 

385                 390                 395                 400 





Ala Leu Pro Pro Ala Ala Asp Ala Pro Val Thr Gln Gly Glu Val Val 

                405                 410                 415     





Pro Thr Gly Ser Glu Gln Thr Thr Glu Ser Glu Thr Pro Val Pro Ala 

            420                 425                 430         





Ala Ala Glu Thr Ala Asp Pro Leu Phe Tyr Pro Ser Trp Tyr Lys Gly 

        435                 440                 445             





Gln Thr Arg Lys Ala Thr Thr Asn Pro Pro Cys Thr Pro Gly Ser Glu 

    450                 455                 460                 





Gly Leu Gly Gln Ile Gly Pro Pro Gly Ser Glu Asp Ser Asn Val Arg 

465                 470                 475                 480 





Lys Ala Glu Val Ala Ala Ala Ala Ala Ser Glu Arg Ala Ala Val Ser 

                485                 490                 495     





Gly Lys Glu Thr Ser Ala Pro Ala Ala Thr Ser Gln Glu Leu Val Ile 

            500                 505                 510         





Cys Leu Ala Leu Leu Ala Phe Leu Ile Leu His Tyr Ile Trp Ser Gln 

        515                 520                 525             





Ile Gln Cys Leu Ile Phe Thr Leu Met Asp Trp Ile 

    530                 535                 540 





<210>  332

<211>  2771

<212>  DNA

<213>  Homo sapiens



<400>  332

tcctgtcact ggcttatatg gacacgtcag cccaccgtca cgtgaccgca ggctgctaaa       60



aacagctcca gcacccactc caaaccaggg cctgaaacaa tgtcctccac cgagagaaac      120



gtaaaggaca cttgatcaca caatccctgg aataatatcc aggaaacact tgctggagcc      180



actcgcagca cccttccctg gcagcacact tggggacagc gaggagatga gcgcatctct      240



gaattacaaa tctttttcca aagagcagca gaccatggat aacttagaga agcaactcat      300



ctgtcccatc tgcttagaga tgttcacgaa acctgtggtg attctccctt gtcagcacaa      360



cctgtgtagg aaatgtgcca gtgatatttt ccaggcctct aacccgtatt tgcccacaag      420



aggaggtacc accatggcat cagggggccg attccgctgc ccatcctgta gacatgaagt      480



ggttttggat agacatgggg tatatggact tcagaggaac ctgctggtgg aaaatatcat      540



tgacatctac aagcaggagt ccaccaggcc agaaaagaaa tccgaccagc ccatgtgcga      600



ggaacatgaa gaggagcgca tcaacatcta ctgtctgaac tgcgaagtac ccacctgctc      660



tctgtgcaag gtgtttggtg cacacaaaga ctgccaggtg gctcccctca ctcatgtgtt      720



ccagagacag aagtctgagc tcagtgatgg catcgccatc ctcgtgggca gcaacgatcg      780



agtccaggga gtgatcagcc agctggaaga cacctgcaaa actatcgagg aatgttgcag      840



aaaacagaaa caagagcttt gtgagaagtt tgattacctg tatggcattt tggaggagag      900



gaagaatgaa atgacccaag tcattacccg aacccaagag gagaaactgg aacatgtccg      960



tgctctgatc aaaaagtatt ctgatcattt ggagaacgtc tcaaagttgg ttgagtcagg     1020



aattcagttt atggatgagc cagaaatggc agtgtttctg cagaatgcca aaaccctgct     1080



aaaaaaaatc tcggaagcat caaaggcatt tcagatggag aaaatagaac atggctatga     1140



gaacatgaac cacttcacag tcaacctcaa tagagaagaa aagataatac gtgaaattga     1200



cttttacaga gaagatgaag atgaagaaga agaagaaggc ggagaaggag aaaaagaagg     1260



agaaggagaa gtgggaggag aagcagtaga agtggaagag gtagaaaatg ttcaaacaga     1320



gtttccagga gaagatgaaa acccagaaaa agcttcagag ctctctcagg tggagctgca     1380



ggctgcccct ggggcacttc cagtttcctc tccagagcca cctccagccc tgccacctgc     1440



tgcggatgcc cctgtgacac agggggaggt tgtacccact ggctctgagc agaccacaga     1500



gtctgaaact ccagtccctg cagcagcaga aactgcggat cccttgtttt accctagttg     1560



gtataaaggc caaacccgga aagccaccac caacccacct tgcaccccag ggagcgaagg     1620



tctggggcaa atagggcctc caggttctga ggattcgaat gtacggaagg cagaagtggc     1680



agcagccgca gcgagtgaga gggcagctgt gagtggtaag gaaactagtg cacctgcagc     1740



tacttctcag attggatttg aggctcctcc cctccaggga caggctgcag ctccagcgag     1800



tggcagtgga gctgattctg agccagctcg ccatatcttc tccttttcct ggttgaactc     1860



cctaaatgaa tgatattcat tccaactgct gcccctctgt ctgcctggct gagatgcatg     1920



tgggcagcag gaagcccaag tgaaattaat attatgcaga tgatgaaagg gacctctgaa     1980



caggatttct gcaaaaatag ccccaaactg caattccata tgacttatct aacatcttgg     2040



ggggaaagaa tattttgaga aaatagttgc agaaagcact ggaaataata aacttgatct     2100



tatacaaatc ttctattgtg tggaaaatgt tgtgaagggt gtgtaggtgt ggtacatgtg     2160



tatgtcacta acaagtggca aatggtgaaa aaagtggtca ctatgctttt gtctctcata     2220



ggcactgact ttttgttatt atattatggt agctttcatt tcctttactc tttaacagtg     2280



caggtggtca gtgaaaatca gtgtcaactc agaagtgact gatttatcaa tacatggaca     2340



aaaagtaaat cattgaccaa agctatgaaa tgtttcacaa agttttcctc ttttgcataa     2400



cagatgtcac tggatgtaca ttcagaaatg ttctttgaat ttggtgacac tttcatggtc     2460



cagaaagctg aaggcctggg catctcttgt gacatttttc taatattagt tttagatttt     2520



cacgtattag gcactttagt tgaatcttcc agcaaaagct gtctactttc tcttttattc     2580



actgtggcac caatctggta aattgtagaa caattgcatg tgtttaaata tatatacaaa     2640



catatcacac attaaatata tatatattta aatcatgctt tgttaatatt tgtcccacca     2700



taatgcctcc ttcagaacat aagtgtaact ttatatgaac tcttaaataa atgatgtttt     2760



taaaaaaaaa a                                                          2771





<210>  333

<211>  548

<212>  PRT

<213>  Homo sapiens



<400>  333



Met Ser Ala Ser Leu Asn Tyr Lys Ser Phe Ser Lys Glu Gln Gln Thr 

1               5                   10                  15      





Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 

            20                  25                  30          





Phe Thr Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 

        35                  40                  45              





Lys Cys Ala Ser Asp Ile Phe Gln Ala Ser Asn Pro Tyr Leu Pro Thr 

    50                  55                  60                  





Arg Gly Gly Thr Thr Met Ala Ser Gly Gly Arg Phe Arg Cys Pro Ser 

65                  70                  75                  80  





Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 

                85                  90                  95      





Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 

            100                 105                 110         





Thr Arg Pro Glu Lys Lys Ser Asp Gln Pro Met Cys Glu Glu His Glu 

        115                 120                 125             





Glu Glu Arg Ile Asn Ile Tyr Cys Leu Asn Cys Glu Val Pro Thr Cys 

    130                 135                 140                 





Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Gln Val Ala Pro 

145                 150                 155                 160 





Leu Thr His Val Phe Gln Arg Gln Lys Ser Glu Leu Ser Asp Gly Ile 

                165                 170                 175     





Ala Ile Leu Val Gly Ser Asn Asp Arg Val Gln Gly Val Ile Ser Gln 

            180                 185                 190         





Leu Glu Asp Thr Cys Lys Thr Ile Glu Glu Cys Cys Arg Lys Gln Lys 

        195                 200                 205             





Gln Glu Leu Cys Glu Lys Phe Asp Tyr Leu Tyr Gly Ile Leu Glu Glu 

    210                 215                 220                 





Arg Lys Asn Glu Met Thr Gln Val Ile Thr Arg Thr Gln Glu Glu Lys 

225                 230                 235                 240 





Leu Glu His Val Arg Ala Leu Ile Lys Lys Tyr Ser Asp His Leu Glu 

                245                 250                 255     





Asn Val Ser Lys Leu Val Glu Ser Gly Ile Gln Phe Met Asp Glu Pro 

            260                 265                 270         





Glu Met Ala Val Phe Leu Gln Asn Ala Lys Thr Leu Leu Lys Lys Ile 

        275                 280                 285             





Ser Glu Ala Ser Lys Ala Phe Gln Met Glu Lys Ile Glu His Gly Tyr 

    290                 295                 300                 





Glu Asn Met Asn His Phe Thr Val Asn Leu Asn Arg Glu Glu Lys Ile 

305                 310                 315                 320 





Ile Arg Glu Ile Asp Phe Tyr Arg Glu Asp Glu Asp Glu Glu Glu Glu 

                325                 330                 335     





Glu Gly Gly Glu Gly Glu Lys Glu Gly Glu Gly Glu Val Gly Gly Glu 

            340                 345                 350         





Ala Val Glu Val Glu Glu Val Glu Asn Val Gln Thr Glu Phe Pro Gly 

        355                 360                 365             





Glu Asp Glu Asn Pro Glu Lys Ala Ser Glu Leu Ser Gln Val Glu Leu 

    370                 375                 380                 





Gln Ala Ala Pro Gly Ala Leu Pro Val Ser Ser Pro Glu Pro Pro Pro 

385                 390                 395                 400 





Ala Leu Pro Pro Ala Ala Asp Ala Pro Val Thr Gln Gly Glu Val Val 

                405                 410                 415     





Pro Thr Gly Ser Glu Gln Thr Thr Glu Ser Glu Thr Pro Val Pro Ala 

            420                 425                 430         





Ala Ala Glu Thr Ala Asp Pro Leu Phe Tyr Pro Ser Trp Tyr Lys Gly 

        435                 440                 445             





Gln Thr Arg Lys Ala Thr Thr Asn Pro Pro Cys Thr Pro Gly Ser Glu 

    450                 455                 460                 





Gly Leu Gly Gln Ile Gly Pro Pro Gly Ser Glu Asp Ser Asn Val Arg 

465                 470                 475                 480 





Lys Ala Glu Val Ala Ala Ala Ala Ala Ser Glu Arg Ala Ala Val Ser 

                485                 490                 495     





Gly Lys Glu Thr Ser Ala Pro Ala Ala Thr Ser Gln Ile Gly Phe Glu 

            500                 505                 510         





Ala Pro Pro Leu Gln Gly Gln Ala Ala Ala Pro Ala Ser Gly Ser Gly 

        515                 520                 525             





Ala Asp Ser Glu Pro Ala Arg His Ile Phe Ser Phe Ser Trp Leu Asn 

    530                 535                 540                 





Ser Leu Asn Glu 

545             





<210>  334

<211>  2483

<212>  DNA

<213>  Homo sapiens



<400>  334

tcctgtcact ggcttatatg gacacgtcag cccaccgtca cgtgaccgca ggctgctaaa       60



aacagctcca gcacccactc caaaccaggg cctgaaacaa tgtcctccac cgagagaaac      120



gtaaaggaca cttgatcaca caatccctgg aataatatcc aggaaacact tgctggagcc      180



actcgcagca cccttccctg gcagcacact tggggacagc gaggagatga gcgcatctct      240



gaattacaaa tctttttcca aagagcagca gaccatggat aacttagaga agcaactcat      300



ctgtcccatc tgcttagaga tgttcacgaa acctgtggtg attctccctt gtcagcacaa      360



cctgtgtagg aaatgtgcca gtgatatttt ccaggcctct aacccgtatt tgcccacaag      420



aggaggtacc accatggcat cagggggccg attccgctgc ccatcctgta gacatgaagt      480



ggttttggat agacatgggg tatatggact tcagaggaac ctgctggtgg aaaatatcat      540



tgacatctac aagcaggagt ccaccaggcc agaaaagaaa tccgaccagc ccatgtgcga      600



ggaacatgaa gaggagcgca tcaacatcta ctgtctgaac tgcgaagtac ccacctgctc      660



tctgtgcaag gtgtttggtg cacacaaaga ctgccaggtg gctcccctca ctcatgtgtt      720



ccagagacag aagtctgagc tcagtgatgg catcgccatc ctcgtgggca gcaacgatcg      780



agtccaggga gtgatcagcc agctggaaga cacctgcaaa actatcgagg aatgttgcag      840



aaaacagaaa caagagcttt gtgagaagtt tgattacctg tatggcattt tggaggagag      900



gaagaatgaa atgacccaag tcattacccg aacccaagag gagaaactgg aacatgtccg      960



tgctctgatc aaaaagtatt ctgatcattt ggagaacgtc tcaaagttgg ttgagtcagg     1020



aattcagttt atggatgagc cagaaatggc agtgtttctg cagaatgcca aaaccctgct     1080



aaaaaaaatc tcggaagcat caaaggcatt tcagatggag aaaatagaac atggctatga     1140



gaacatgaac cacttcacag tcaacctcaa tagagaagaa aagataatac gtgaaattga     1200



cttttacaga gaagatgaag atgaagaaga agaagaaggc ggagaaggag aaaaagaagg     1260



agaaggagaa gtgggaggag aagcagtaga agtggaagag gtagaaaatg ttcaaacaga     1320



gtttccagga gaagatgaaa acccagaaaa agcttcagag ctctctcagg tggagctgca     1380



ggctgcccct ggggcacttc cagtttcctc tccagagcca cctccagccc tgccacctgc     1440



tgcggatgcc cctgtgacac agattggatt tgaggctcct cccctccagg gacaggctgc     1500



agctccagcg agtggcagtg gagctgattc tgagccagct cgccatatct tctccttttc     1560



ctggttgaac tccctaaatg aatgatattc attccaactg ctgcccctct gtctgcctgg     1620



ctgagatgca tgtgggcagc aggaagccca agtgaaatta atattatgca gatgatgaaa     1680



gggacctctg aacaggattt ctgcaaaaat agccccaaac tgcaattcca tatgacttat     1740



ctaacatctt ggggggaaag aatattttga gaaaatagtt gcagaaagca ctggaaataa     1800



taaacttgat cttatacaaa tcttctattg tgtggaaaat gttgtgaagg gtgtgtaggt     1860



gtggtacatg tgtatgtcac taacaagtgg caaatggtga aaaaagtggt cactatgctt     1920



ttgtctctca taggcactga ctttttgtta ttatattatg gtagctttca tttcctttac     1980



tctttaacag tgcaggtggt cagtgaaaat cagtgtcaac tcagaagtga ctgatttatc     2040



aatacatgga caaaaagtaa atcattgacc aaagctatga aatgtttcac aaagttttcc     2100



tcttttgcat aacagatgtc actggatgta cattcagaaa tgttctttga atttggtgac     2160



actttcatgg tccagaaagc tgaaggcctg ggcatctctt gtgacatttt tctaatatta     2220



gttttagatt ttcacgtatt aggcacttta gttgaatctt ccagcaaaag ctgtctactt     2280



tctcttttat tcactgtggc accaatctgg taaattgtag aacaattgca tgtgtttaaa     2340



tatatataca aacatatcac acattaaata tatatatatt taaatcatgc tttgttaata     2400



tttgtcccac cataatgcct ccttcagaac ataagtgtaa ctttatatga actcttaaat     2460



aaatgatgtt tttaaaaaaa aaa                                             2483





<210>  335

<211>  452

<212>  PRT

<213>  Homo sapiens



<400>  335



Met Ser Ala Ser Leu Asn Tyr Lys Ser Phe Ser Lys Glu Gln Gln Thr 

1               5                   10                  15      





Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 

            20                  25                  30          





Phe Thr Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 

        35                  40                  45              





Lys Cys Ala Ser Asp Ile Phe Gln Ala Ser Asn Pro Tyr Leu Pro Thr 

    50                  55                  60                  





Arg Gly Gly Thr Thr Met Ala Ser Gly Gly Arg Phe Arg Cys Pro Ser 

65                  70                  75                  80  





Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 

                85                  90                  95      





Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 

            100                 105                 110         





Thr Arg Pro Glu Lys Lys Ser Asp Gln Pro Met Cys Glu Glu His Glu 

        115                 120                 125             





Glu Glu Arg Ile Asn Ile Tyr Cys Leu Asn Cys Glu Val Pro Thr Cys 

    130                 135                 140                 





Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Gln Val Ala Pro 

145                 150                 155                 160 





Leu Thr His Val Phe Gln Arg Gln Lys Ser Glu Leu Ser Asp Gly Ile 

                165                 170                 175     





Ala Ile Leu Val Gly Ser Asn Asp Arg Val Gln Gly Val Ile Ser Gln 

            180                 185                 190         





Leu Glu Asp Thr Cys Lys Thr Ile Glu Glu Cys Cys Arg Lys Gln Lys 

        195                 200                 205             





Gln Glu Leu Cys Glu Lys Phe Asp Tyr Leu Tyr Gly Ile Leu Glu Glu 

    210                 215                 220                 





Arg Lys Asn Glu Met Thr Gln Val Ile Thr Arg Thr Gln Glu Glu Lys 

225                 230                 235                 240 





Leu Glu His Val Arg Ala Leu Ile Lys Lys Tyr Ser Asp His Leu Glu 

                245                 250                 255     





Asn Val Ser Lys Leu Val Glu Ser Gly Ile Gln Phe Met Asp Glu Pro 

            260                 265                 270         





Glu Met Ala Val Phe Leu Gln Asn Ala Lys Thr Leu Leu Lys Lys Ile 

        275                 280                 285             





Ser Glu Ala Ser Lys Ala Phe Gln Met Glu Lys Ile Glu His Gly Tyr 

    290                 295                 300                 





Glu Asn Met Asn His Phe Thr Val Asn Leu Asn Arg Glu Glu Lys Ile 

305                 310                 315                 320 





Ile Arg Glu Ile Asp Phe Tyr Arg Glu Asp Glu Asp Glu Glu Glu Glu 

                325                 330                 335     





Glu Gly Gly Glu Gly Glu Lys Glu Gly Glu Gly Glu Val Gly Gly Glu 

            340                 345                 350         





Ala Val Glu Val Glu Glu Val Glu Asn Val Gln Thr Glu Phe Pro Gly 

        355                 360                 365             





Glu Asp Glu Asn Pro Glu Lys Ala Ser Glu Leu Ser Gln Val Glu Leu 

    370                 375                 380                 





Gln Ala Ala Pro Gly Ala Leu Pro Val Ser Ser Pro Glu Pro Pro Pro 

385                 390                 395                 400 





Ala Leu Pro Pro Ala Ala Asp Ala Pro Val Thr Gln Ile Gly Phe Glu 

                405                 410                 415     





Ala Pro Pro Leu Gln Gly Gln Ala Ala Ala Pro Ala Ser Gly Ser Gly 

            420                 425                 430         





Ala Asp Ser Glu Pro Ala Arg His Ile Phe Ser Phe Ser Trp Leu Asn 

        435                 440                 445             





Ser Leu Asn Glu 

    450         





<210>  336

<211>  1850

<212>  DNA

<213>  Homo sapiens



<400>  336

tcctgtcact ggcttatatg gacacgtcag cccaccgtca cgtgaccgca ggctgctaaa       60



aacagctcca gcacccactc caaaccaggg cctgaaacaa tgtcctccac cgagagaaac      120



gtaaaggaca cttgatcaca caatccctgg aataatatcc aggaaacact tgctggagcc      180



actcgcagca cccttccctg gcagcacact tggggacagc gaggagatga gcgcatctct      240



gaattacaaa tctttttcca aagagcagca gaccatggat aacttagaga agcaactcat      300



ctgtcccatc tgcttagaga tgttcacgaa acctgtggtg attctccctt gtcagcacaa      360



cctgtgtagg aaatgtgcca gtgatatttt ccaggcctct aacccgtatt tgcccacaag      420



aggaggtacc accatggcat cagggggccg attccgctgc ccatcctgta gacatgaagt      480



ggttttggat agacatgggg tatatggact tcagaggaac ctgctggtgg aaaatatcat      540



tgacatctac aagcaggagt ccaccaggcc agaaaagaaa tccgaccagc ccatgtgcga      600



ggaacatgaa gaggagcgca tcaacatcta ctgtctgaac tgcgaagtac ccacctgctc      660



tctgtgcaag gtgtttggtg cacacaaaga ctgccaggtg gctcccctca ctcatgtgtt      720



ccagagacag aagtctgagc tcagtgatgg catcgccatc ctcgtgggca gcaacgatcg      780



agtccaggga gtgatcagcc agctggaaga cacctgcaaa actatcgaga ttggatttga      840



ggctcctccc ctccagggac aggctgcagc tccagcgagt ggcagtggag ctgattctga      900



gccagctcgc catatcttct ccttttcctg gttgaactcc ctaaatgaat gatattcatt      960



ccaactgctg cccctctgtc tgcctggctg agatgcatgt gggcagcagg aagcccaagt     1020



gaaattaata ttatgcagat gatgaaaggg acctctgaac aggatttctg caaaaatagc     1080



cccaaactgc aattccatat gacttatcta acatcttggg gggaaagaat attttgagaa     1140



aatagttgca gaaagcactg gaaataataa acttgatctt atacaaatct tctattgtgt     1200



ggaaaatgtt gtgaagggtg tgtaggtgtg gtacatgtgt atgtcactaa caagtggcaa     1260



atggtgaaaa aagtggtcac tatgcttttg tctctcatag gcactgactt tttgttatta     1320



tattatggta gctttcattt cctttactct ttaacagtgc aggtggtcag tgaaaatcag     1380



tgtcaactca gaagtgactg atttatcaat acatggacaa aaagtaaatc attgaccaaa     1440



gctatgaaat gtttcacaaa gttttcctct tttgcataac agatgtcact ggatgtacat     1500



tcagaaatgt tctttgaatt tggtgacact ttcatggtcc agaaagctga aggcctgggc     1560



atctcttgtg acatttttct aatattagtt ttagattttc acgtattagg cactttagtt     1620



gaatcttcca gcaaaagctg tctactttct cttttattca ctgtggcacc aatctggtaa     1680



attgtagaac aattgcatgt gtttaaatat atatacaaac atatcacaca ttaaatatat     1740



atatatttaa atcatgcttt gttaatattt gtcccaccat aatgcctcct tcagaacata     1800



agtgtaactt tatatgaact cttaaataaa tgatgttttt aaaaaaaaaa                1850





<210>  337

<211>  241

<212>  PRT

<213>  Homo sapiens



<400>  337



Met Ser Ala Ser Leu Asn Tyr Lys Ser Phe Ser Lys Glu Gln Gln Thr 

1               5                   10                  15      





Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 

            20                  25                  30          





Phe Thr Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 

        35                  40                  45              





Lys Cys Ala Ser Asp Ile Phe Gln Ala Ser Asn Pro Tyr Leu Pro Thr 

    50                  55                  60                  





Arg Gly Gly Thr Thr Met Ala Ser Gly Gly Arg Phe Arg Cys Pro Ser 

65                  70                  75                  80  





Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 

                85                  90                  95      





Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 

            100                 105                 110         





Thr Arg Pro Glu Lys Lys Ser Asp Gln Pro Met Cys Glu Glu His Glu 

        115                 120                 125             





Glu Glu Arg Ile Asn Ile Tyr Cys Leu Asn Cys Glu Val Pro Thr Cys 

    130                 135                 140                 





Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Gln Val Ala Pro 

145                 150                 155                 160 





Leu Thr His Val Phe Gln Arg Gln Lys Ser Glu Leu Ser Asp Gly Ile 

                165                 170                 175     





Ala Ile Leu Val Gly Ser Asn Asp Arg Val Gln Gly Val Ile Ser Gln 

            180                 185                 190         





Leu Glu Asp Thr Cys Lys Thr Ile Glu Ile Gly Phe Glu Ala Pro Pro 

        195                 200                 205             





Leu Gln Gly Gln Ala Ala Ala Pro Ala Ser Gly Ser Gly Ala Asp Ser 

    210                 215                 220                 





Glu Pro Ala Arg His Ile Phe Ser Phe Ser Trp Leu Asn Ser Leu Asn 

225                 230                 235                 240 





Glu 

    





<210>  338

<211>  5158

<212>  DNA

<213>  Homo sapiens



<400>  338

gggagacggt gcgggcggcc gggagcgcag ccctccggga ggcgggtcat ggcctgggcg       60



ccgcccgggg agcggctgcg cgaggatgcg cggtgcccgg tgtgcctgga tttcctgcag      120



gagccggtca gcgtggactg cggccacagc ttctgcctca ggtgcatctc cgagttctgc      180



gagaagtcgg acggcgcgca gggcggcgtc tacgcctgtc cgcagtgccg gggccccttc      240



cggccctcgg gctttcgccc caaccggcag ctggcgggcc tggtggagag cgtgcggcgg      300



ctggggttgg gcgcggggcc cggggcgcgg cgatgcgcgc ggcacggcga ggacctgagc      360



cgcttctgcg aggaggacga ggcggcgctg tgctgggtgt gcgacgccgg ccccgagcac      420



aggacgcacc gcacggcgcc gctgcaggag gccgccggca gctaccaggt aaagctccag      480



atggctctgg aacttatgag gaaagagttg gaggacgcct tgactcagga ggccaacgtg      540



gggaaaaaga ctgtcatttg gaaggagaaa gtggaaatgc agaggcagcg cttcagattg      600



gagtttgaga agcatcgtgg ctttctggcc caggaggagc aacggcagct gaggcggctg      660



gaggcggagg agcgagcgac gctgcagaga ctgcgggaga gcaagagccg gctggtccag      720



cagagcaagg ccctgaagga gctggcggat gagctgcagg agaggtgcca gcgcccggcc      780



ctgggtctgc tggagggtgt gagaggagtc ctgagcagaa gtaaggctgt cacaaggctg      840



gaagcagaga acatccccat ggaactgaag acagcatgct gcatccctgg gaggagggag      900



ctcttaagga agttccaagt ggatgtaaag ctggatcccg ccacggcgca cccgagtctg      960



ctcttgaccg ccgacctgcg cagtgtgcag gatggagaac catggaggga tgtccccaac     1020



aaccctgagc gatttgacac atggccctgc atcctgggtt tgcagagctt ctcatcaggg     1080



aggcattact gggaggttct ggtgggagaa ggagcagagt ggggtttagg ggtctgtcaa     1140



gacacactgc caagaaaggg ggaaaccacg ccatctcctg agaatggggt ctgggccctg     1200



tggctgctga aagggaatga gtacatggtc cttgcctccc catcagtgcc tcttctccaa     1260



ctggaaagtc ctcgctgcat tgggattttc ttggactatg aagccggtga aatttcattc     1320



tacaatgtca cagatggatc ttatatctac acattcaacc aactcttctc tggtcttctt     1380



cggccttact ttttcatctg tgatgcaact cctcttatct tgccacccac aacaatagca     1440



gggtcaggaa attgggcatc cagggatcat ttagatcctg cttctgatgt aagagatgat     1500



catctctaaa attctgttcc caagatgcag tcctagcgta gcgaacgttc ctggagtggg     1560



gtgaaggata tcaatatact aagttttaac agatacccca tttaggtcag cacttgattc     1620



gttgttgctg tgaaatatgt ccatgggaca aaagagggaa tatgaaatat ttgcatatgg     1680



gaagattata gagcataata attttgtaaa tggagcaatc tcaacctcta tttctagatc     1740



acattttctt gatgtcttcc ttcaaattaa tgaccttgga ttacataagg atttctatgc     1800



attcattata atttgttatt cctttcaata tccttgtatt tcaaatcttc catataagaa     1860



ttagacatgg caattcttaa attgattcag aatggtctga tactattcca gtatcacctc     1920



cttaattctg tttctcctcg ttttcctgat tttccttctc attctctcct tccccgctct     1980



gtctctctct ccctgtcact ctctctctct tgttccttat tttttgtttc ttacctctta     2040



ctgtttaacc tgttgcttcc ttctggatta atacatttag agccattcct ttatatggtc     2100



acatttccta tgactttact caattacttt taaaatcctt tctattctga gactaatttt     2160



taagaattac aaagctcatt cttctgaatc taatatcact aactcctaga ctttttccgt     2220



tttctttgga tacactttaa gtaggaattt atcagaattt tcattcaact cgttctttaa     2280



tgcagatatt tactagttat aagaccttaa ggctgggtgc agtggctcac gcctgtaatc     2340



ccagcacttt gggaggctga ggcgggtgga tcacaagctc aggagttcaa gaccagcctg     2400



gccaacatgg tgaaaccctg tctctactaa aaaaaaaaaa aaaatagaaa aattagctgg     2460



gcatggtggc aggagcctgt aatcccagct attctggagg tggagacagg agaattgctt     2520



gaaccctgga ggcggaggtt gcagtgagcc aatatctcac cactgtactc cagcccagtg     2580



cgagactcca tctcaaaaaa gaaaaaagac ctcaaacaac acttctctct ctcttttagc     2640



tgcttgttat ggttcctata catggaacaa ttatactggc ctcactgtgt tatggtaaat     2700



atttaaggtc atatttgata ttgctggttt gaattcagct tttccattta aatacattat     2760



aatgatgatg atgaaatcat gataatattt aacttatttt taaagtatat tctgtacctt     2820



tccaacaaaa aggttaaaag tcattgaagg ctaaccttac tgccttcttt gtatcactgt     2880



cttctaaata attattatgt ctgggtacag tggctcacgc ctgtaatccc agcactttgg     2940



gaggccgagg tgggcagatc acgaggtcag gagattgaga ccatcctggc taacacagtg     3000



aaaccccgtc tctactaaaa atacaaaaag aaattagctg ggcgtggtgg tgggtgcctg     3060



ttgtcccagc tacttgggag gctgaggcag gagaatggca tgaacccagg aggcagagct     3120



tgtagtgagc cgagatcgcg ccactgcact ccagccgggg caacagagca agactccatc     3180



tcaaaaataa ataaataaat aaataaataa ataaataaat aaataaatat tacacaaatg     3240



ctaaaatgtt taaatggtaa atgcttcaat gctaaccaaa tattaattaa tggcaaatta     3300



tttaacatta tctgataata atctgcagaa ggtttaattt tcctcctcaa tttgaagttc     3360



aagatgtttt tctcttccag ggagattttt tcgactgaca tctttaactt accttccaat     3420



catattacta acgtagcctt cttcctagat tttttaattg tttgatcatg agcgaacact     3480



tctactctct gtgatagatt tgcaaacaga ggaaataacg catcctcgtg tccctcttct     3540



tggtgttcca caggccatgt gtgccctagc cctcgttcat gcaaggtctg tgtagggaag     3600



gtggacttca gctcagcaac agcatccctt cccacaggga tcaggtgggt ggcttgagat     3660



accccttcca tggggcacca cccattcagt gagacgggga agccctgggt gggagggaga     3720



acacctccac atgtcttcta ctctctccat aggatggaat gagtgtccca gtcccaggag     3780



tatccatttc ccactgtgta gcccagtact ctggtctcac tgtctctgct gaatcctgtc     3840



tcactgtgca tattattgtg gtttatatca gtcagtaaac caatgtgagt cttcatctct     3900



tgcattctta ggttcatagt tttgtgtgtc tcctgtaatg actcttctct ttccctttcc     3960



aactcctgaa agattgccac tatttcctct ggaactttgt ttcgttacca gcaaaatcct     4020



cgacatccat acccgtttcc tggctttccc tctcctttcc tctgaatggt agtcttttat     4080



attcagctgt ccacttgaca tcaaaataga cattttgaac tcaatttgcc taaaacttac     4140



ccacaaattt ctccccaagt ctctccctaa ctgcaacaac aaaaaccaca ggcttctccc     4200



tgtcactgga tggcaactcc attcttttga ttgcttaagc caggcatccg attgagtact     4260



ttcttgattt ctccagccca catccagtcc atcggcaagc cctgttggtc ctaccttcag     4320



aatatgtccg gggttcagtt gtcctggcca ccctgctgct gtaaccatgg tcagaactcc     4380



atcctgcccc tctggattat gactttcgtt tcctcacagt ggtcctgctt gggctctagg     4440



cccttccact cccattctct ctacagcagc tgggctgatt cctttagcac ccaaggatat     4500



gttggcatca cagtgactta gataccatca caaagacctc ccattcaact tagagtgaaa     4560



gtcagaatcc tcacagtgaa tccccaggcc ctagaggatg tgaaccccca ggccctagag     4620



gatctgaacc cccatccctc ctctgattat ctctcccacc cccacttccc tttgcattct     4680



gctccagctg ccctggcctc atggctgggt ttccaccaaa gcaggcactt cccatcacag     4740



ggccatttcc ccgcctgtgg cttctgcttg acattccctt ttccctgata tccccttgac     4800



tcattattcc ctttcttcct taactcttct gagatccagc ttctcagtga taccacacag     4860



ccctactccc cccagagccc atctagagct cacctttcca gtcgcccttg ccaggctcag     4920



tggaggctct ttgttcccca tacagtacgt gtcgtcgtac tatattgtta ggcttattta     4980



atttatgtat gttttgcctt tttgtgctaa atgtaaacac cacaagggga ggtatctttg     5040



tctgttgaca atgatacatt caatgtttct caagcacccc caatgctggt ttgtatgtgg     5100



ttatcattca atctgtattt gttgaatgaa taaatgattg actatgtgga gagcaaaa       5158





<210>  339

<211>  486

<212>  PRT

<213>  Homo sapiens



<400>  339



Met Ala Trp Ala Pro Pro Gly Glu Arg Leu Arg Glu Asp Ala Arg Cys 

1               5                   10                  15      





Pro Val Cys Leu Asp Phe Leu Gln Glu Pro Val Ser Val Asp Cys Gly 

            20                  25                  30          





His Ser Phe Cys Leu Arg Cys Ile Ser Glu Phe Cys Glu Lys Ser Asp 

        35                  40                  45              





Gly Ala Gln Gly Gly Val Tyr Ala Cys Pro Gln Cys Arg Gly Pro Phe 

    50                  55                  60                  





Arg Pro Ser Gly Phe Arg Pro Asn Arg Gln Leu Ala Gly Leu Val Glu 

65                  70                  75                  80  





Ser Val Arg Arg Leu Gly Leu Gly Ala Gly Pro Gly Ala Arg Arg Cys 

                85                  90                  95      





Ala Arg His Gly Glu Asp Leu Ser Arg Phe Cys Glu Glu Asp Glu Ala 

            100                 105                 110         





Ala Leu Cys Trp Val Cys Asp Ala Gly Pro Glu His Arg Thr His Arg 

        115                 120                 125             





Thr Ala Pro Leu Gln Glu Ala Ala Gly Ser Tyr Gln Val Lys Leu Gln 

    130                 135                 140                 





Met Ala Leu Glu Leu Met Arg Lys Glu Leu Glu Asp Ala Leu Thr Gln 

145                 150                 155                 160 





Glu Ala Asn Val Gly Lys Lys Thr Val Ile Trp Lys Glu Lys Val Glu 

                165                 170                 175     





Met Gln Arg Gln Arg Phe Arg Leu Glu Phe Glu Lys His Arg Gly Phe 

            180                 185                 190         





Leu Ala Gln Glu Glu Gln Arg Gln Leu Arg Arg Leu Glu Ala Glu Glu 

        195                 200                 205             





Arg Ala Thr Leu Gln Arg Leu Arg Glu Ser Lys Ser Arg Leu Val Gln 

    210                 215                 220                 





Gln Ser Lys Ala Leu Lys Glu Leu Ala Asp Glu Leu Gln Glu Arg Cys 

225                 230                 235                 240 





Gln Arg Pro Ala Leu Gly Leu Leu Glu Gly Val Arg Gly Val Leu Ser 

                245                 250                 255     





Arg Ser Lys Ala Val Thr Arg Leu Glu Ala Glu Asn Ile Pro Met Glu 

            260                 265                 270         





Leu Lys Thr Ala Cys Cys Ile Pro Gly Arg Arg Glu Leu Leu Arg Lys 

        275                 280                 285             





Phe Gln Val Asp Val Lys Leu Asp Pro Ala Thr Ala His Pro Ser Leu 

    290                 295                 300                 





Leu Leu Thr Ala Asp Leu Arg Ser Val Gln Asp Gly Glu Pro Trp Arg 

305                 310                 315                 320 





Asp Val Pro Asn Asn Pro Glu Arg Phe Asp Thr Trp Pro Cys Ile Leu 

                325                 330                 335     





Gly Leu Gln Ser Phe Ser Ser Gly Arg His Tyr Trp Glu Val Leu Val 

            340                 345                 350         





Gly Glu Gly Ala Glu Trp Gly Leu Gly Val Cys Gln Asp Thr Leu Pro 

        355                 360                 365             





Arg Lys Gly Glu Thr Thr Pro Ser Pro Glu Asn Gly Val Trp Ala Leu 

    370                 375                 380                 





Trp Leu Leu Lys Gly Asn Glu Tyr Met Val Leu Ala Ser Pro Ser Val 

385                 390                 395                 400 





Pro Leu Leu Gln Leu Glu Ser Pro Arg Cys Ile Gly Ile Phe Leu Asp 

                405                 410                 415     





Tyr Glu Ala Gly Glu Ile Ser Phe Tyr Asn Val Thr Asp Gly Ser Tyr 

            420                 425                 430         





Ile Tyr Thr Phe Asn Gln Leu Phe Ser Gly Leu Leu Arg Pro Tyr Phe 

        435                 440                 445             





Phe Ile Cys Asp Ala Thr Pro Leu Ile Leu Pro Pro Thr Thr Ile Ala 

    450                 455                 460                 





Gly Ser Gly Asn Trp Ala Ser Arg Asp His Leu Asp Pro Ala Ser Asp 

465                 470                 475                 480 





Val Arg Asp Asp His Leu 

                485     





<210>  340

<211>  5302

<212>  DNA

<213>  Homo sapiens



<400>  340

atccacccgc gacccacatc cgatcggtac cggagcggga ggtgaggggt cggctcgcgg       60



atccagctgc agagcgacgt ggggaattgg aatggtgctt tggatcttat ggaggccatt      120



tggattctca ggaagatttc tgaaactgga aagccatagc ataactgaat caaaatcgtt      180



gattccagta gcttggacat ccctgacaca gatgcttttg gaagcacctg gtattttctt      240



attgggtcaa agaaaaagat tctcaaccat gccagaaaca gaaacacatg agagagagac      300



tgaattgttt tcaccacctt ctgatgtccg aggcatgaca aaacttgata gaacagcttt      360



taaaaagaca gtcaacattc cagtgcttaa agtgaggaaa gaaatagtca gtaaattgat      420



gcgatcccta aaaagggcag cattgcagcg cccaggcata agacgtgtga ttgaagatcc      480



ggaagataaa gaaagtagac taatcatgtt ggatccctat aaaatattta ctcatgattc      540



ctttgagaaa gcagaactca gtgttttaga gcagcttaat gtcagtccac agatctctaa      600



atacaatttg gaactaacat atgaacactt taagtcagaa gaaatcttga gagctgtgct      660



tcctgaaggt caagatgtaa cttcagggtt tagcaggatt ggacatattg cacacctaaa      720



ccttcgagat catcagctgt ctttcaaaca tttaattggc caggttatga ttgacaaaaa      780



tccaggaatc acctcagcag taaataaaat aaataatatt gacaatatgt accgaaattt      840



ccaaatggaa gtgctatctg gagagcagaa catgatgaca aaggttcgag aaaacaacta      900



cacctatgaa tttgattttt caaaagtcta ttggaatcct cgtctgtcta cagaacacag      960



ccgtatcaca gaacttctca aacctgggga tgtcctattt gatgtttttg ctggggttgg     1020



gccctttgcc attccagtag caaagaaaaa ctgcactgta tttgccaatg atctcaatcc     1080



tgaatctcat aaatggctgt tgtacaactg taaattaaat aaagtggacc aaaaggtgaa     1140



agtcttcaac ttggatggga aagacttcct ccaaggacca gtcaaagaag agttaatgca     1200



gctgctgggt ctgtcaaaag aaagaaaacc ctctgtgcac gttgtcatga acttgccagc     1260



aaaagctata gagtttctta gtgctttcaa gtggctttta gatgggcagc catgcagcag     1320



tgagttcctt cccatagtgc attgttatag cttttccaaa gatgctaacc ctgctgagga     1380



tgttcggcaa agggctggag ctgtgttagg catttctctg gaggcatgca gttcagttca     1440



cctggtaaga aatgtggccc caaacaagga aatgctgtgc atcacgtttc agattcctgc     1500



ctctgtcctc tacaagaacc agaccagaaa tccagagaat catgaagatc cacctcttaa     1560



aaggcagagg acggctgaag ccttttcaga cgaaaaaaca caaattgttt caaacactta     1620



attggaaatg ttttctccat ctccctacca gacttacatg tagtgaaata gaatttgtat     1680



tatttaataa aattttaggg tttggttttt actattgaac ccttgtactt tgccttattt     1740



tacaaattga ggattaccaa ttaaacttta actgaactaa ggctaccaaa tacattccct     1800



gttatctaaa ttataacata caattatttt ataacaaaat atatctaatt tttattggat     1860



aaatatgaat aaatattttc tctcagggaa aataattttt gaaagtaggg tgattgagta     1920



ctaactagga aggtattaac accactttgt agttgtcctt tacgtaacta ctcctttact     1980



gccaattaac tatcaccata aaagtaataa aaaatgaaat tatttagaac ggggcaggca     2040



aactacatcc tgcaggccaa atctgtccca ccacctgttt tcatatggcc tgtggcctaa     2100



taatgttctt acgttttcca ttggttgaaa aataatcaaa agaacatttt gtgacgtgaa     2160



aattttatga catctattat gtatcagttt taaaaattag aattgtatga aattaagagt     2220



ttcagagttc ataaagtttg attggaacat accatgctca tttgtttaca tatcatctgc     2280



agctgttttt tgtttttaat atggaacgct tcacgaattt gcatgtcatc cttgcgcagg     2340



gaccattctg atcttctctg taccattcca gttttttagt atatgtgctg ctgaagtgag     2400



gactgcagct gctttcttga acaatagcag agttgagtgg ttgcaacaca cactgaatgt     2460



gactgtcatc acttcacact gctgtttgac acatcacaaa tcactgatgt ggttgtaacg     2520



acagcatttt gagtgccatg tatatcacat gaacccacat tttatttttt attaccagag     2580



catatctatt atagcaaaac aagaaaagtg gactttgttg ttatttttaa agtacagtag     2640



ggtgtgaatt attttgatgt tgaattagac gacaaagcat ctatatagct aagctaaaag     2700



aataaccatt gacattacca gacaaaccac tcatcacagt attcccaact cacaggcaag     2760



caactgttag aaaaattaga aaatttaaaa tggaaataac aaagcagaat ttcttcacaa     2820



aatgaaaatg aggctgcaac aacagtaagt ctctaagtca atcatttgtt agccaagcaa     2880



agccatttat tgatggtgtg aattaattat gtttggatgc agcagctgaa tatatccaga     2940



gaaaataaac ttaagattac tggcctttgg caagaacagt tgcttaaaga gttaaggaca     3000



ttgaaagcga cataaatagt cactttaaaa aggaaatgat tctggatggt tctttgactc     3060



tatttttatt tttacttaga gacagggtct tgctctgttg cccaggctgg agtgtagaga     3120



cacagttaca cctcaatgta accttgaact cctaggcttg agatcttccc atctcggctt     3180



cccaatgtgt gaaggttaca ggtgtgagcc cttatatgtg gccctcgtga atggtttagc     3240



actatcccct tggtggtgtc cttaagataa tgagttatga gatcttgttg tttcaaagta     3300



tgtggcactc gccccccaca ctctcttgct cctgccttcg ccatgtgaag tgccttctcc     3360



tattttgcct tctaccatga gtaaaagctt cctgaggctt ccccagaagc agatgccagt     3420



gctatgcttc ctatagcctg gagaactgtg agccaattat acctcttttc ttataaatta     3480



cccagtatca agtatttctt tatagcaatg caagaatggc ctaaaacaca aggcaaaaca     3540



actttgatat ggtacagtca ttttgacaat cgatatttga atcacaatat ttgatgacaa     3600



tatccttaca catttgtcat actatcaaag agaaagaaac aagatttcca ttcccacaaa     3660



ttttagtgag tatattttct gagttcagca tttttaggga cctaggtgca agtgcaaagg     3720



aaatttccct gtttcaaaat ctatttaact gcaattgagg tgattcaacc taattttcag     3780



taagaagtga ttaaaataat gacatgctaa aaggcaaatt tcaagggaag aaatgtaaaa     3840



gaattttaca aatgctttcc aagtgatgaa tatgctcagt taatttcata tgctcctgga     3900



ttgatagcag tatttggcaa tacctatctg tatgagaaga catttttaaa gatgaaatgt     3960



gtaaaatctt attaccatta gtattaatgg ttaatgatgg ttaatgataa ccattaatag     4020



gcaatcattt acaactgatt ttgatcacag ggaacactta cttagaaccc tgattagagg     4080



caatgttatt ctcaccaaaa aaggcattac aaaaaattgg gctatatttt gaattttgtc     4140



aattaaaaaa gcgtgggagc agtgtgaagg agaagaggca agaacgaccc ctggaccgac     4200



caaagcccgc gcgctgctgc gtcccacacc cggtgcccac atcccgccgc cgccgccgcc     4260



gccatgccca agagaaagac tgaaggggat gctaaaggag ataaagccaa ggtgaaggat     4320



gaatcacaga gaagatctgc gaggttgtct gctaaacctg ctcctccaaa gccagagccc     4380



aagcctaaaa aggcccctgc aaagaaggga gagaaggtac ccaaagggaa aaagagaaaa     4440



gctgatgctg gcaaggagcg ggaaggtgct ggagatccca agtgaagtgt gtgcattttt     4500



tataactgta cttctggtga ctgtacagtt tgaaatattc tttatcaagt tttataaaaa     4560



tgcagaattt tgttttactt tttttaagct atgttgttag cacacagaac acttcattgt     4620



tgtttttggg ggaaggggta tgtgtcacta atagaatatc tctgaagctg gattgatacg     4680



gggaaaacat ctttcccttc tagttttgag agacttcctc ttggctccca ggaggaggga     4740



tttcctgact ttgacacaca tggccacctt ggcacaaaag ccttgtggta tggaaaaaca     4800



aattcgtttt tatgtcttct tttccctttc catctttcag catagactta atccccttaa     4860



gcccagacat ctgttgggac ctgacccccg gtcattggtt accagtgtgt ctggcaatct     4920



ggactttcca gtgatgccac tgagatggca cctgtcaaaa gagcagtggt tccatttcta     4980



gattatggat cttcggataa attctgccat tttcatttca cttcctgaaa gtcagggttg     5040



gcttgtgaaa agttgttaaa caacatgcta aatgtgaaat gttaaccctc taaactttcc     5100



ctgttcagag catcagatga ggacttcatt gggttttata gcggctgatt tttggtagtc     5160



cattgaagaa gagagtttga aagttgtata ctgttaatga ctgtctgccc atgtcctgcc     5220



tgaaatacca tgattgttta tggaaagtat ctttaataaa gctggataca gtttgaaaga     5280



aaaaaaaaaa aaaaaaaaaa aa                                              5302





<210>  341

<211>  509

<212>  PRT

<213>  Homo sapiens



<400>  341



Met Val Leu Trp Ile Leu Trp Arg Pro Phe Gly Phe Ser Gly Arg Phe 

1               5                   10                  15      





Leu Lys Leu Glu Ser His Ser Ile Thr Glu Ser Lys Ser Leu Ile Pro 

            20                  25                  30          





Val Ala Trp Thr Ser Leu Thr Gln Met Leu Leu Glu Ala Pro Gly Ile 

        35                  40                  45              





Phe Leu Leu Gly Gln Arg Lys Arg Phe Ser Thr Met Pro Glu Thr Glu 

    50                  55                  60                  





Thr His Glu Arg Glu Thr Glu Leu Phe Ser Pro Pro Ser Asp Val Arg 

65                  70                  75                  80  





Gly Met Thr Lys Leu Asp Arg Thr Ala Phe Lys Lys Thr Val Asn Ile 

                85                  90                  95      





Pro Val Leu Lys Val Arg Lys Glu Ile Val Ser Lys Leu Met Arg Ser 

            100                 105                 110         





Leu Lys Arg Ala Ala Leu Gln Arg Pro Gly Ile Arg Arg Val Ile Glu 

        115                 120                 125             





Asp Pro Glu Asp Lys Glu Ser Arg Leu Ile Met Leu Asp Pro Tyr Lys 

    130                 135                 140                 





Ile Phe Thr His Asp Ser Phe Glu Lys Ala Glu Leu Ser Val Leu Glu 

145                 150                 155                 160 





Gln Leu Asn Val Ser Pro Gln Ile Ser Lys Tyr Asn Leu Glu Leu Thr 

                165                 170                 175     





Tyr Glu His Phe Lys Ser Glu Glu Ile Leu Arg Ala Val Leu Pro Glu 

            180                 185                 190         





Gly Gln Asp Val Thr Ser Gly Phe Ser Arg Ile Gly His Ile Ala His 

        195                 200                 205             





Leu Asn Leu Arg Asp His Gln Leu Ser Phe Lys His Leu Ile Gly Gln 

    210                 215                 220                 





Val Met Ile Asp Lys Asn Pro Gly Ile Thr Ser Ala Val Asn Lys Ile 

225                 230                 235                 240 





Asn Asn Ile Asp Asn Met Tyr Arg Asn Phe Gln Met Glu Val Leu Ser 

                245                 250                 255     





Gly Glu Gln Asn Met Met Thr Lys Val Arg Glu Asn Asn Tyr Thr Tyr 

            260                 265                 270         





Glu Phe Asp Phe Ser Lys Val Tyr Trp Asn Pro Arg Leu Ser Thr Glu 

        275                 280                 285             





His Ser Arg Ile Thr Glu Leu Leu Lys Pro Gly Asp Val Leu Phe Asp 

    290                 295                 300                 





Val Phe Ala Gly Val Gly Pro Phe Ala Ile Pro Val Ala Lys Lys Asn 

305                 310                 315                 320 





Cys Thr Val Phe Ala Asn Asp Leu Asn Pro Glu Ser His Lys Trp Leu 

                325                 330                 335     





Leu Tyr Asn Cys Lys Leu Asn Lys Val Asp Gln Lys Val Lys Val Phe 

            340                 345                 350         





Asn Leu Asp Gly Lys Asp Phe Leu Gln Gly Pro Val Lys Glu Glu Leu 

        355                 360                 365             





Met Gln Leu Leu Gly Leu Ser Lys Glu Arg Lys Pro Ser Val His Val 

    370                 375                 380                 





Val Met Asn Leu Pro Ala Lys Ala Ile Glu Phe Leu Ser Ala Phe Lys 

385                 390                 395                 400 





Trp Leu Leu Asp Gly Gln Pro Cys Ser Ser Glu Phe Leu Pro Ile Val 

                405                 410                 415     





His Cys Tyr Ser Phe Ser Lys Asp Ala Asn Pro Ala Glu Asp Val Arg 

            420                 425                 430         





Gln Arg Ala Gly Ala Val Leu Gly Ile Ser Leu Glu Ala Cys Ser Ser 

        435                 440                 445             





Val His Leu Val Arg Asn Val Ala Pro Asn Lys Glu Met Leu Cys Ile 

    450                 455                 460                 





Thr Phe Gln Ile Pro Ala Ser Val Leu Tyr Lys Asn Gln Thr Arg Asn 

465                 470                 475                 480 





Pro Glu Asn His Glu Asp Pro Pro Leu Lys Arg Gln Arg Thr Ala Glu 

                485                 490                 495     





Ala Phe Ser Asp Glu Lys Thr Gln Ile Val Ser Asn Thr 

            500                 505                 





<210>  342

<211>  1817

<212>  DNA

<213>  Homo sapiens



<400>  342

attcattact acagggcagg aagggcacgt tctcatcagc atgagggagt gcctttccat       60



ccacatcggt caagctggca tccagattgg ggacgcctgc tgggaactct attgcctgga      120



acatggaatc cagccaaatg gcgttgttct tgacactcaa caggatcagc tggaaaatgc      180



aaaaatggag cacacaaatg catctttcga taccttcttc tgtgagacaa gagctgggaa      240



gcatgtgcct agagcactct tcgtggactt ggagccaact gttatagatg ggatccggac      300



gggccagcac cgttcactct tccaccccga gcagctcctt agcggaaagg aggatgctgc      360



caacaattac gcgcgaggcc gttactctgt ggggtcggag gtcatcgacc ttgtgctgga      420



gaggacccgg aagctggcag aacagtgtgg tggacttcag ggatttttga ttttccgaag      480



ctttggagga ggcactggtt cagggtttac gtctctctta atggagaggc tcacaggaga      540



atatagcaga aagactaagc tggagttctc ggtctaccca gcccccagga tctccactgc      600



cgtggtagag ccttataact ctgtcctcac cacccactcc accacagagc acacggactg      660



taccttcatg gtggacaacg aggccgtcta tgatatatgc catcgtaaac tcggtgttga      720



atgcccctct catgccagca tcaatagatt ggtggttcag gtggtatctt ccatcactgc      780



ctccctccgg tttgaagggc ccttgaatgt agacctaatt gaattccaga ccaacctggt      840



accttatccg agaatacatt tccccatgac agccttcgcc cccatcgtct ctgctgacaa      900



agcctaccat gagcagttct ctgtgtcaga catcaccact gcttgctttg agtcctccaa      960



ccagctggtc aagtgtgatc ctcggcttgg gaagtacatg gcctgctgcc tactctatag     1020



aggggatgtg gtccccaagg aagtgaatgc agcaatcgca gccacgaagt cgaggcactc     1080



tgttcagttt gtagattggt gtccaactgg tttcaaggtg ggcatcaaca atcggccgcc     1140



cacggtgatg ccgggtgggg acctggccaa agtccaccgg tccatctgca tgctgagcaa     1200



caccacggcg attgtggagg cctgggcccg cctggaccac aagtttgacc tcatgtacgc     1260



caagagagca tttctgcact ggtacctcag agaaggcatg gaagaagcag agttcttgga     1320



ggccagggaa gatctggcag ccctggagag ggactatgag gaagtggcgc aaagtttctg     1380



aggcatgtat gatgggtgca aatgaatgtc aagttaaaat ggcatgtttt cttttcaagc     1440



cgttatatgc ctagtgggta gttcccctga tgagcagaaa aatgaactca aatcaggcaa     1500



gactctaggt tccacactaa attaagtggg tcagtaccaa caatgaacac attatttcct     1560



ggtctactgg tacaagtcag ctctgctacc tgggagcctt tggaagctta gagtcctttg     1620



aactgctgag tcacttctag gtgggatttt tttgttttac caagagacaa tgaaatccta     1680



aagtttatgc ttttcctttc tggtaccgga agtagaaaac agcacatgtt gattacgaat     1740



gttttttccc ccatgtctac attttttaca ctgattaaat cataaatatt ttcagtatga     1800



aaaaaaaaaa aaaaaaa                                                    1817





<210>  343

<211>  446

<212>  PRT

<213>  Homo sapiens



<400>  343



Met Arg Glu Cys Leu Ser Ile His Ile Gly Gln Ala Gly Ile Gln Ile 

1               5                   10                  15      





Gly Asp Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 

            20                  25                  30          





Asn Gly Val Val Leu Asp Thr Gln Gln Asp Gln Leu Glu Asn Ala Lys 

        35                  40                  45              





Met Glu His Thr Asn Ala Ser Phe Asp Thr Phe Phe Cys Glu Thr Arg 

    50                  55                  60                  





Ala Gly Lys His Val Pro Arg Ala Leu Phe Val Asp Leu Glu Pro Thr 

65                  70                  75                  80  





Val Ile Asp Gly Ile Arg Thr Gly Gln His Arg Ser Leu Phe His Pro 

                85                  90                  95      





Glu Gln Leu Leu Ser Gly Lys Glu Asp Ala Ala Asn Asn Tyr Ala Arg 

            100                 105                 110         





Gly Arg Tyr Ser Val Gly Ser Glu Val Ile Asp Leu Val Leu Glu Arg 

        115                 120                 125             





Thr Arg Lys Leu Ala Glu Gln Cys Gly Gly Leu Gln Gly Phe Leu Ile 

    130                 135                 140                 





Phe Arg Ser Phe Gly Gly Gly Thr Gly Ser Gly Phe Thr Ser Leu Leu 

145                 150                 155                 160 





Met Glu Arg Leu Thr Gly Glu Tyr Ser Arg Lys Thr Lys Leu Glu Phe 

                165                 170                 175     





Ser Val Tyr Pro Ala Pro Arg Ile Ser Thr Ala Val Val Glu Pro Tyr 

            180                 185                 190         





Asn Ser Val Leu Thr Thr His Ser Thr Thr Glu His Thr Asp Cys Thr 

        195                 200                 205             





Phe Met Val Asp Asn Glu Ala Val Tyr Asp Ile Cys His Arg Lys Leu 

    210                 215                 220                 





Gly Val Glu Cys Pro Ser His Ala Ser Ile Asn Arg Leu Val Val Gln 

225                 230                 235                 240 





Val Val Ser Ser Ile Thr Ala Ser Leu Arg Phe Glu Gly Pro Leu Asn 

                245                 250                 255     





Val Asp Leu Ile Glu Phe Gln Thr Asn Leu Val Pro Tyr Pro Arg Ile 

            260                 265                 270         





His Phe Pro Met Thr Ala Phe Ala Pro Ile Val Ser Ala Asp Lys Ala 

        275                 280                 285             





Tyr His Glu Gln Phe Ser Val Ser Asp Ile Thr Thr Ala Cys Phe Glu 

    290                 295                 300                 





Ser Ser Asn Gln Leu Val Lys Cys Asp Pro Arg Leu Gly Lys Tyr Met 

305                 310                 315                 320 





Ala Cys Cys Leu Leu Tyr Arg Gly Asp Val Val Pro Lys Glu Val Asn 

                325                 330                 335     





Ala Ala Ile Ala Ala Thr Lys Ser Arg His Ser Val Gln Phe Val Asp 

            340                 345                 350         





Trp Cys Pro Thr Gly Phe Lys Val Gly Ile Asn Asn Arg Pro Pro Thr 

        355                 360                 365             





Val Met Pro Gly Gly Asp Leu Ala Lys Val His Arg Ser Ile Cys Met 

    370                 375                 380                 





Leu Ser Asn Thr Thr Ala Ile Val Glu Ala Trp Ala Arg Leu Asp His 

385                 390                 395                 400 





Lys Phe Asp Leu Met Tyr Ala Lys Arg Ala Phe Leu His Trp Tyr Leu 

                405                 410                 415     





Arg Glu Gly Met Glu Glu Ala Glu Phe Leu Glu Ala Arg Glu Asp Leu 

            420                 425                 430         





Ala Ala Leu Glu Arg Asp Tyr Glu Glu Val Ala Gln Ser Phe 

        435                 440                 445     





<210>  344

<211>  3545

<212>  DNA

<213>  Homo sapiens



<400>  344

gggcggccgg gtggcggcgg cggcatggcg gagccgagcg gggccgagac gaggcccccc       60



attcgggtca ccgtcaagac ccccaaggac aaggaggaaa ttgtgatctg cgatcgagcc      120



tcggtcaagg agttcaaaga ggaaatctcc cggaggttta aggctcagca ggatcagctg      180



gtcctgatct tcgcaggcaa gatcctcaag gatggggaca cactgaacca gcacggaatc      240



aaggacgggc tcactgtcca tctggtcatc aagacccctc agaaggctca agatccagct      300



gctgccactg cttcttcccc ctccacacct gaccctgcct cagcaccctc caccacgcct      360



gcttcacccg ccacccctgc ccagccctcc acctctggca gtgcctcttc agatgctggc      420



agtggaagcc ggaggagcag tggtgggggg ccctctccgg gggctgggga gggatccccc      480



agtgctactg cgtccatact ctctggcttt gggggcatcc tggggctggg cagcctaggc      540



ctgggctctg ccaacttcat ggagctgcag cagcagatgc agcggcagct gatgtccaat      600



cctgagatgc tgtcacagat catggagaac cccctggtcc aggatatgat gtctaaccct      660



gatctgatgc gtcacatgat tatggccaac ccccagatgc agcagttgat ggagcggaac      720



cctgagatca gccacatgct caataaccct gaactcatga ggcagacaat ggagcttgct      780



cggaatccag ccatgatgca agagatgatg cggaaccagg accgggccct gagcaacctt      840



gagagcatcc ctggagggta taatgccctc cgccgcatgt acacggacat ccaggagccc      900



atgttcagtg ctgcccggga acagtttggc aacaatccct tctcttccct ggccgggaac      960



tccgacagct catcctccca gcctctgcgg actgagaatc gagagcccct ccctaacccc     1020



tggagcccct cgccccccac ctcccaggcc cccgggtccg gtggggaggg caccggagga     1080



tcggggacca gccaggtgca cccgacagtc tcgaacccct ttgggatcaa tgcggctagc     1140



ctggggtcag ggatgttcaa tagcccagaa atgcaagccc tcctccagca gatctctgag     1200



aacccccagc tgatgcagaa tgtgatctca gcaccctaca tgcgcagcat gatgcagacg     1260



cttgcccaga accccgactt tgctgctcag atgatggtga atgtgccgct cttcgcgggg     1320



aacccccaac tgcaggagca gctccgcctg cagctcccag tcttcctgca gcagatgcag     1380



aacccagagt cactctccat ccttaccaat ccccgagcca tgcaggcatt gctgcagatc     1440



cagcagggac tacagacctt gcagaccgag gcccctgggc tggtacccag ccttggctcc     1500



tttgggatat cccggacccc agcaccctca gcaggcagca acgcagggtc tacgcccgag     1560



gcccccactt cctcaccagc cacgccagcc acatcttctc caacaggggc ttccagcgcc     1620



cagcagcaac tcatgcagca gatgatccag cttttggctg gaagtggaaa ctcacaggtg     1680



cagacgccag aagtgagatt tcagcagcag ctggagcagc tcaactccat gggcttcatc     1740



aatcgtgagg ctaacctgca ggccctgatt gccacaggag gggacatcaa cgcagctatc     1800



gagagactgc tgggctccca gctctcctaa tccctcggcc catgcctcct gcctctcccc     1860



tccctcgatg tcagcattcg gttcttctgt caatccttac cctctgcagc ttgtcctccc     1920



ttccgtcttc tccctcatcc tttccaaaca gcagggtgac tttagaggca tgggctccaa     1980



ccccttagct ctgtctgaga attatggttt tactgctacg tctctaacag actcttctct     2040



cctggtctcc ttgagcagtg ctacttaaac agttttcaca gtttcattga ttgactctac     2100



ctccttgccc cacaccactt ttgcaatctt taaactttca gtggctgtgc agagtcgagg     2160



gaggaaccag ctctctggtt tactggaaca tagtcttcca tctataccac tagggttttg     2220



tcttatgttt acttttggta actctcttcc ttctttttct ccctaccccc caacccctag     2280



cccaaccaat gctagaattt cttgctctga aggaggagca ggtgaaacag gtggtaattt     2340



tccttctcgg cccctattct ggttcattca gcactttttg gtgggaactg ttggaaattc     2400



cagggtaagg aggaagatgc ctgttctccc tgtctgaaga gggagatgag acagctctct     2460



ggacaggaat taacaaacgc tggagcagcc cagaggaaat tcgtgtgaaa gaggagggaa     2520



tgagattatt cggaggaagg gaatggggga gacagcctga gtaaaaggct tggaagttgg     2580



aattagcagt ggggagcaga agcactcata gctcttttag gcagaagaat ccaggcccga     2640



gctggcagaa gagacttaga gatgctaatg gaatttaaac tgaaaaaagg agcccaatga     2700



agctaagcgc cacgccccac aaggggtcat attggcttta gttcctcaag catatgtgct     2760



tatatgcaca cacacacaca tttccatgga cccaggtctt gcttgtgtcc ccaggcacca     2820



gtagtttgag cccccctcaa aagacatgaa gggggttggg gtctgtgtga gtagtgggga     2880



ggtgcatgtg tatccacatg tgtgcataca ctcttaagtt gggtgggaag tggattcctt     2940



gttggtttct ggttcagagt gctctcccac caccagagac aagtgggtaa aaaggtcagt     3000



ccattgcagg aatatatatc cgggagagct aggtcccttg gggctctgga tgctgggtaa     3060



cccagaggta atgtgggtac cctttctgaa gctgtcaggg ctgtgactag cacccttatc     3120



acccctcact gccttgtggg aatagtagag ggtttttttc ctccagagcc cctggccttt     3180



cagttcttaa ctatttccct ccaggccaga aagttttctt tgaggaagga gaggagaggg     3240



tggcaatgat gcctttgatc tggaattgga catttctctg tcagagcaca gaggaggctc     3300



atatcacctc ttccctctcc tacttggccc agctgcttgg aggaccgacc ccatggctga     3360



gaatatgacg gcaagaggaa cagagtttgc tccaagtggg aaagggtccc aagcagtcca     3420



gagaagatgt ctgtgtggct ttccctccct gcctccccca gctcccacac tggcctttgt     3480



aaataaatgg cgtggtcttt gttgtgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3540



aaaaa                                                                 3545





<210>  345

<211>  601

<212>  PRT

<213>  Homo sapiens



<400>  345



Met Ala Glu Pro Ser Gly Ala Glu Thr Arg Pro Pro Ile Arg Val Thr 

1               5                   10                  15      





Val Lys Thr Pro Lys Asp Lys Glu Glu Ile Val Ile Cys Asp Arg Ala 

            20                  25                  30          





Ser Val Lys Glu Phe Lys Glu Glu Ile Ser Arg Arg Phe Lys Ala Gln 

        35                  40                  45              





Gln Asp Gln Leu Val Leu Ile Phe Ala Gly Lys Ile Leu Lys Asp Gly 

    50                  55                  60                  





Asp Thr Leu Asn Gln His Gly Ile Lys Asp Gly Leu Thr Val His Leu 

65                  70                  75                  80  





Val Ile Lys Thr Pro Gln Lys Ala Gln Asp Pro Ala Ala Ala Thr Ala 

                85                  90                  95      





Ser Ser Pro Ser Thr Pro Asp Pro Ala Ser Ala Pro Ser Thr Thr Pro 

            100                 105                 110         





Ala Ser Pro Ala Thr Pro Ala Gln Pro Ser Thr Ser Gly Ser Ala Ser 

        115                 120                 125             





Ser Asp Ala Gly Ser Gly Ser Arg Arg Ser Ser Gly Gly Gly Pro Ser 

    130                 135                 140                 





Pro Gly Ala Gly Glu Gly Ser Pro Ser Ala Thr Ala Ser Ile Leu Ser 

145                 150                 155                 160 





Gly Phe Gly Gly Ile Leu Gly Leu Gly Ser Leu Gly Leu Gly Ser Ala 

                165                 170                 175     





Asn Phe Met Glu Leu Gln Gln Gln Met Gln Arg Gln Leu Met Ser Asn 

            180                 185                 190         





Pro Glu Met Leu Ser Gln Ile Met Glu Asn Pro Leu Val Gln Asp Met 

        195                 200                 205             





Met Ser Asn Pro Asp Leu Met Arg His Met Ile Met Ala Asn Pro Gln 

    210                 215                 220                 





Met Gln Gln Leu Met Glu Arg Asn Pro Glu Ile Ser His Met Leu Asn 

225                 230                 235                 240 





Asn Pro Glu Leu Met Arg Gln Thr Met Glu Leu Ala Arg Asn Pro Ala 

                245                 250                 255     





Met Met Gln Glu Met Met Arg Asn Gln Asp Arg Ala Leu Ser Asn Leu 

            260                 265                 270         





Glu Ser Ile Pro Gly Gly Tyr Asn Ala Leu Arg Arg Met Tyr Thr Asp 

        275                 280                 285             





Ile Gln Glu Pro Met Phe Ser Ala Ala Arg Glu Gln Phe Gly Asn Asn 

    290                 295                 300                 





Pro Phe Ser Ser Leu Ala Gly Asn Ser Asp Ser Ser Ser Ser Gln Pro 

305                 310                 315                 320 





Leu Arg Thr Glu Asn Arg Glu Pro Leu Pro Asn Pro Trp Ser Pro Ser 

                325                 330                 335     





Pro Pro Thr Ser Gln Ala Pro Gly Ser Gly Gly Glu Gly Thr Gly Gly 

            340                 345                 350         





Ser Gly Thr Ser Gln Val His Pro Thr Val Ser Asn Pro Phe Gly Ile 

        355                 360                 365             





Asn Ala Ala Ser Leu Gly Ser Gly Met Phe Asn Ser Pro Glu Met Gln 

    370                 375                 380                 





Ala Leu Leu Gln Gln Ile Ser Glu Asn Pro Gln Leu Met Gln Asn Val 

385                 390                 395                 400 





Ile Ser Ala Pro Tyr Met Arg Ser Met Met Gln Thr Leu Ala Gln Asn 

                405                 410                 415     





Pro Asp Phe Ala Ala Gln Met Met Val Asn Val Pro Leu Phe Ala Gly 

            420                 425                 430         





Asn Pro Gln Leu Gln Glu Gln Leu Arg Leu Gln Leu Pro Val Phe Leu 

        435                 440                 445             





Gln Gln Met Gln Asn Pro Glu Ser Leu Ser Ile Leu Thr Asn Pro Arg 

    450                 455                 460                 





Ala Met Gln Ala Leu Leu Gln Ile Gln Gln Gly Leu Gln Thr Leu Gln 

465                 470                 475                 480 





Thr Glu Ala Pro Gly Leu Val Pro Ser Leu Gly Ser Phe Gly Ile Ser 

                485                 490                 495     





Arg Thr Pro Ala Pro Ser Ala Gly Ser Asn Ala Gly Ser Thr Pro Glu 

            500                 505                 510         





Ala Pro Thr Ser Ser Pro Ala Thr Pro Ala Thr Ser Ser Pro Thr Gly 

        515                 520                 525             





Ala Ser Ser Ala Gln Gln Gln Leu Met Gln Gln Met Ile Gln Leu Leu 

    530                 535                 540                 





Ala Gly Ser Gly Asn Ser Gln Val Gln Thr Pro Glu Val Arg Phe Gln 

545                 550                 555                 560 





Gln Gln Leu Glu Gln Leu Asn Ser Met Gly Phe Ile Asn Arg Glu Ala 

                565                 570                 575     





Asn Leu Gln Ala Leu Ile Ala Thr Gly Gly Asp Ile Asn Ala Ala Ile 

            580                 585                 590         





Glu Arg Leu Leu Gly Ser Gln Leu Ser 

        595                 600     





<210>  346

<211>  2794

<212>  DNA

<213>  Homo sapiens



<400>  346

cttcaagatt atcaataatc ggagatacgt atattttatt tgtaaagaaa acatggctgc       60



cctattccta cgtggttttg tccaaatagg gaactgcaag actgggatat ctaagtcaaa      120



agaagcattc attgaagcag tggaaagaaa gaagaaagat agactggtgc tgtatttcaa      180



aagtggaaaa tatagcactt ttcggctaag tgataatatt caaaatgtag tccttaaatc      240



ctatagagga aaccaaaatc acctgcattt aactttacaa aataataatg gcttgtttat      300



tgaaggatta tcctccacag atgctgaaca attgaagata ttcttggaca gagttcatca      360



aaacgaggtt cagccacctg tgagacctgg taagggtggg agtgtctttt ctagcacaac      420



acagaaggaa atcaacaaaa cttcattcca caaagttgat gagaaatcaa gtagcaaatc      480



ttttgagata gcaaaaggaa gtgggacagg tgtccttcag aggatgcctt tgcttacatc      540



aaaattgaca cttacttgcg gagagttatc agaaaatcag cacaagaaga ggaaaagaat      600



gctctcatct agctcagaga tgaatgagga attcttgaaa gaaaataatt ctgtagaata      660



caagaaatcc aaggcagatt gttcgaggtg tgtaagctat aatcgagaga aacaattgaa      720



gttaaaagag ttagaagaga ataagaaatt ggaatgtgaa tcttcatgca tcatgaacgc      780



cactggaaat ccttacctag atgacattgg tcttctccaa gctctcactg agaaaatggt      840



tttggtattt ctgttacaac aagggtatag tgacggttac acaaagtggg ataaattaaa      900



actatttttt gaattatttc cagagaaaat atgccacggc ctccccaatt tgggaaacac      960



ctgttatatg aatgcagtgt tacagtctct actttcaatc ccatcgtttg ctgatgattt     1020



acttaatcag agtttcccat ggggtaaaat tccccttaat gctcttacca tgtgcttggc     1080



acggctactt ttttttaaag atacctataa tatagaaatc aaggagatgt tactcttgaa     1140



tcttaaaaag gccatttcag cagctgcaga gatattccat ggcaatgcac agaacgatgc     1200



tcatgagttt ttagctcact gtttagatca actgaaagat aacatggaaa aactcaacac     1260



aatttggaag cctaaaagtg aatttgggga agataatttt cctaaacagg tttttgctga     1320



tgatcctgac accagtgggt tttcttgccc tgtcattact aattttgagt tagagttgtt     1380



gcactccatt gcttgtaaag cttgtggtca ggttattctc aagacagaac tgaataatta     1440



cctctccatc aaccttcccc aaagaataaa agcacatcct tcatctattc agtctacttt     1500



tgatcttttt tttggagcag aagagcttga gtataaatgt gcaaaatgtg agcacaagac     1560



ttccgttgga gtgcactcat tcagtaggct acctagaatc cttattgttc acctcaaacg     1620



ctatagcttg aatgagtttt gtgcattaaa gaagaatgac caggaagtca tcatttccaa     1680



atatttaaag gtgtcttctc attgcaatga aggcaccaga ccacctcttc ccttgagtga     1740



ggatggagaa attacagatt tccaattatt aaaagttatt cgaaagatga cttctggaaa     1800



catcagtgta tcatggcctg caacaaagga atccaaagat atcctggctc cacacattgg     1860



atcagataag gagtctgaac aaaaaaaagg ccagacagtc tttaaagggg caagcagaag     1920



acagcagcaa aagtaccttg gaaaaaattc taaaccaaat gagctagaat ctgtatactc     1980



aggagatcga gcattcattg aaaaagaacc gttagctcac ttaatgacgt atctggaaga     2040



tacctcactt tgtcagttcc acaaagctgg aggtaaacct gccagcagcc caggcacacc     2100



tctctcaaaa gttgactttc aaacagtgcc cgaaaatcca aaacgaaaga aatatgtgaa     2160



aaccagtaag tttgtagctt ttgataggat tatcaatcct actaaagatt tgtatgaaga     2220



taaaaatatc agaattccag aaagattcca aaaagtgtct gaacagactc agcagtgtga     2280



cggtatgaga atctgtgaac aagcccctca gcaggcactg cctcaaagct ttccaaagcc     2340



aggcacccag gggcacacaa agaacctcct aagacctaca aaattaaatc tacagaagtc     2400



taacaggaat tccctacttg cactgggttc caataagaat ccaagaaaca aagacatttt     2460



agataagata aaatctaaag ccaaggaaac aaaaagaaat gatgataagg gagatcatac     2520



ctaccggctc attagtgttg tcagccatct tgggaagact ctaaagtcag gccattatat     2580



ctgtgatgcc tatgactttg agaaacagat ctggttcact tacgatgata tgcgggtgtt     2640



aggtatccag gaggcccaga tgcaggagga taggcgttgc actgggtaca tcttctttta     2700



catgcataat gagatctttg aagagatgtt gaaaagagaa gagaatgccc agcttaatag     2760



caaggaggta gaggagaccc ttcagaagga ataa                                 2794





<210>  347

<211>  913

<212>  PRT

<213>  Homo sapiens



<400>  347



Met Ala Ala Leu Phe Leu Arg Gly Phe Val Gln Ile Gly Asn Cys Lys 

1               5                   10                  15      





Thr Gly Ile Ser Lys Ser Lys Glu Ala Phe Ile Glu Ala Val Glu Arg 

            20                  25                  30          





Lys Lys Lys Asp Arg Leu Val Leu Tyr Phe Lys Ser Gly Lys Tyr Ser 

        35                  40                  45              





Thr Phe Arg Leu Ser Asp Asn Ile Gln Asn Val Val Leu Lys Ser Tyr 

    50                  55                  60                  





Arg Gly Asn Gln Asn His Leu His Leu Thr Leu Gln Asn Asn Asn Gly 

65                  70                  75                  80  





Leu Phe Ile Glu Gly Leu Ser Ser Thr Asp Ala Glu Gln Leu Lys Ile 

                85                  90                  95      





Phe Leu Asp Arg Val His Gln Asn Glu Val Gln Pro Pro Val Arg Pro 

            100                 105                 110         





Gly Lys Gly Gly Ser Val Phe Ser Ser Thr Thr Gln Lys Glu Ile Asn 

        115                 120                 125             





Lys Thr Ser Phe His Lys Val Asp Glu Lys Ser Ser Ser Lys Ser Phe 

    130                 135                 140                 





Glu Ile Ala Lys Gly Ser Gly Thr Gly Val Leu Gln Arg Met Pro Leu 

145                 150                 155                 160 





Leu Thr Ser Lys Leu Thr Leu Thr Cys Gly Glu Leu Ser Glu Asn Gln 

                165                 170                 175     





His Lys Lys Arg Lys Arg Met Leu Ser Ser Ser Ser Glu Met Asn Glu 

            180                 185                 190         





Glu Phe Leu Lys Glu Asn Asn Ser Val Glu Tyr Lys Lys Ser Lys Ala 

        195                 200                 205             





Asp Cys Ser Arg Cys Val Ser Tyr Asn Arg Glu Lys Gln Leu Lys Leu 

    210                 215                 220                 





Lys Glu Leu Glu Glu Asn Lys Lys Leu Glu Cys Glu Ser Ser Cys Ile 

225                 230                 235                 240 





Met Asn Ala Thr Gly Asn Pro Tyr Leu Asp Asp Ile Gly Leu Leu Gln 

                245                 250                 255     





Ala Leu Thr Glu Lys Met Val Leu Val Phe Leu Leu Gln Gln Gly Tyr 

            260                 265                 270         





Ser Asp Gly Tyr Thr Lys Trp Asp Lys Leu Lys Leu Phe Phe Glu Leu 

        275                 280                 285             





Phe Pro Glu Lys Ile Cys His Gly Leu Pro Asn Leu Gly Asn Thr Cys 

    290                 295                 300                 





Tyr Met Asn Ala Val Leu Gln Ser Leu Leu Ser Ile Pro Ser Phe Ala 

305                 310                 315                 320 





Asp Asp Leu Leu Asn Gln Ser Phe Pro Trp Gly Lys Ile Pro Leu Asn 

                325                 330                 335     





Ala Leu Thr Met Cys Leu Ala Arg Leu Leu Phe Phe Lys Asp Thr Tyr 

            340                 345                 350         





Asn Ile Glu Ile Lys Glu Met Leu Leu Leu Asn Leu Lys Lys Ala Ile 

        355                 360                 365             





Ser Ala Ala Ala Glu Ile Phe His Gly Asn Ala Gln Asn Asp Ala His 

    370                 375                 380                 





Glu Phe Leu Ala His Cys Leu Asp Gln Leu Lys Asp Asn Met Glu Lys 

385                 390                 395                 400 





Leu Asn Thr Ile Trp Lys Pro Lys Ser Glu Phe Gly Glu Asp Asn Phe 

                405                 410                 415     





Pro Lys Gln Val Phe Ala Asp Asp Pro Asp Thr Ser Gly Phe Ser Cys 

            420                 425                 430         





Pro Val Ile Thr Asn Phe Glu Leu Glu Leu Leu His Ser Ile Ala Cys 

        435                 440                 445             





Lys Ala Cys Gly Gln Val Ile Leu Lys Thr Glu Leu Asn Asn Tyr Leu 

    450                 455                 460                 





Ser Ile Asn Leu Pro Gln Arg Ile Lys Ala His Pro Ser Ser Ile Gln 

465                 470                 475                 480 





Ser Thr Phe Asp Leu Phe Phe Gly Ala Glu Glu Leu Glu Tyr Lys Cys 

                485                 490                 495     





Ala Lys Cys Glu His Lys Thr Ser Val Gly Val His Ser Phe Ser Arg 

            500                 505                 510         





Leu Pro Arg Ile Leu Ile Val His Leu Lys Arg Tyr Ser Leu Asn Glu 

        515                 520                 525             





Phe Cys Ala Leu Lys Lys Asn Asp Gln Glu Val Ile Ile Ser Lys Tyr 

    530                 535                 540                 





Leu Lys Val Ser Ser His Cys Asn Glu Gly Thr Arg Pro Pro Leu Pro 

545                 550                 555                 560 





Leu Ser Glu Asp Gly Glu Ile Thr Asp Phe Gln Leu Leu Lys Val Ile 

                565                 570                 575     





Arg Lys Met Thr Ser Gly Asn Ile Ser Val Ser Trp Pro Ala Thr Lys 

            580                 585                 590         





Glu Ser Lys Asp Ile Leu Ala Pro His Ile Gly Ser Asp Lys Glu Ser 

        595                 600                 605             





Glu Gln Lys Lys Gly Gln Thr Val Phe Lys Gly Ala Ser Arg Arg Gln 

    610                 615                 620                 





Gln Gln Lys Tyr Leu Gly Lys Asn Ser Lys Pro Asn Glu Leu Glu Ser 

625                 630                 635                 640 





Val Tyr Ser Gly Asp Arg Ala Phe Ile Glu Lys Glu Pro Leu Ala His 

                645                 650                 655     





Leu Met Thr Tyr Leu Glu Asp Thr Ser Leu Cys Gln Phe His Lys Ala 

            660                 665                 670         





Gly Gly Lys Pro Ala Ser Ser Pro Gly Thr Pro Leu Ser Lys Val Asp 

        675                 680                 685             





Phe Gln Thr Val Pro Glu Asn Pro Lys Arg Lys Lys Tyr Val Lys Thr 

    690                 695                 700                 





Ser Lys Phe Val Ala Phe Asp Arg Ile Ile Asn Pro Thr Lys Asp Leu 

705                 710                 715                 720 





Tyr Glu Asp Lys Asn Ile Arg Ile Pro Glu Arg Phe Gln Lys Val Ser 

                725                 730                 735     





Glu Gln Thr Gln Gln Cys Asp Gly Met Arg Ile Cys Glu Gln Ala Pro 

            740                 745                 750         





Gln Gln Ala Leu Pro Gln Ser Phe Pro Lys Pro Gly Thr Gln Gly His 

        755                 760                 765             





Thr Lys Asn Leu Leu Arg Pro Thr Lys Leu Asn Leu Gln Lys Ser Asn 

    770                 775                 780                 





Arg Asn Ser Leu Leu Ala Leu Gly Ser Asn Lys Asn Pro Arg Asn Lys 

785                 790                 795                 800 





Asp Ile Leu Asp Lys Ile Lys Ser Lys Ala Lys Glu Thr Lys Arg Asn 

                805                 810                 815     





Asp Asp Lys Gly Asp His Thr Tyr Arg Leu Ile Ser Val Val Ser His 

            820                 825                 830         





Leu Gly Lys Thr Leu Lys Ser Gly His Tyr Ile Cys Asp Ala Tyr Asp 

        835                 840                 845             





Phe Glu Lys Gln Ile Trp Phe Thr Tyr Asp Asp Met Arg Val Leu Gly 

    850                 855                 860                 





Ile Gln Glu Ala Gln Met Gln Glu Asp Arg Arg Cys Thr Gly Tyr Ile 

865                 870                 875                 880 





Phe Phe Tyr Met His Asn Glu Ile Phe Glu Glu Met Leu Lys Arg Glu 

                885                 890                 895     





Glu Asn Ala Gln Leu Asn Ser Lys Glu Val Glu Glu Thr Leu Gln Lys 

            900                 905                 910         





Glu 

    





<210>  348

<211>  7971

<212>  DNA

<213>  Homo sapiens



<400>  348

ctaaaaatac cattaagtaa tagtattagc ttttgtattc tgagattcaa cagcagcagt       60



cacttccctc cactcctatg tgtatcccag gaccaccctg ggcggggagg gctgaggtca      120



gggaggtctg aagctggtcc tgggctccgg gggtgacagt gatgaggaac tgggtgcaca      180



catgagtggg gcagccgggc ctggccagag aagcaacaca cacgtgcaca gacatgttta      240



tccacataca catgtgcacg catgtgcaca aacacattgc aggcaggcat gttgacgcct      300



caggcagcgg aggaccctga ctctgggccc tgctgaccca ggcaaggccc cattgtgatg      360



cgtgccatga cctcagaatg tcactggtgc ttagcaccta tccgctctcc agactgcgtc      420



tgtgttctac ggcagttaca cacacgcagt ggtattcaca agcggttttg tggactcaaa      480



ggttttctcc ctgagaggca taacccaggc cagctgattc atcagaatca ggtgagtgtg      540



acctgctctc ttccctccag gctgacttgg ggacagtggc tatggtatgg gcggtgttgg      600



cctctgggca gctacagagg agggtcatcc ctgagcactc accgggcgcc cgttctacac      660



tgcccatgta gacgattttc tctttcgtct tcatggtggc ttcgtagagt gggtgctgtt      720



cccaaatgta cccattcgac aggtgagccg tctggggtca gagaggcagt aactggcctg      780



ggaatccaga caagaccctg ggttttgctc tcagccctgc tgtgtgccat gctagacttc      840



aggcctcaac cctgagacct ccctgctcta gatcccaaat ctgcccagat ttccgatccc      900



aatggggcag agcctggccc tggcagagac actgggatgg atccactgtg ggtggggagg      960



agggaagggt cctcagaaca cacctggggc ctaagctggg tcttgatggt cactgtggga     1020



cccactggac acacacagtc ccttgtctgg gagtggcatg gggagccttc tgcccttggg     1080



cagttgtgga aagtgaagga gccctggaga gctggctgag gggagactat cttcccttgt     1140



gttcaaaggg gtccaggcac tggggctctc cccaagtatt tcttattctg tctggcctcg     1200



ctttcctttt gccctgagta ttctcaggag ggacggtcca tctagatgtc ctccaggagc     1260



aaggacccac tgttcttcat cagtgaccca ggaaaatgaa gccccctcct gtggggacag     1320



ctcagaatgg tggagtccac agtccctccc tgagagacat ggtttccatg agcacagtgg     1380



ctgctttgga gacagtaatc attttcatcc ccaaaaccaa acacactcct gctcaaatgg     1440



tgttattgct aaagcagctt cactggttag actgaagggc catggtagcc caagtgatga     1500



gcggggtaga atggagcagt caggagagat cttgttcccc gtaggaaact gggcatctct     1560



gtggccctga acatcccagg aggccgatcg tacagagacc tctggtgcct gaccgcagtt     1620



cacatccaca tccctggaat agaccatcac aggctcttca cccttggcag gtggacacca     1680



ttcaacctgc cggggcagga tggacatggt agagaatgca gatagtttgc aggcacagga     1740



gcggaaggac atacttatga agtatgacaa gggacaccga gctgggctgc cagaggacaa     1800



ggggcctgag cccgttggaa tcaacagcag cattgatcgt tttggcattt tgcatgagac     1860



ggagctgcct cctgtgactg cacgggaggc gaagaaaatt cggcgggaga tgacacgaac     1920



gagcaagtgg atggaaatgc tgggagaatg ggagacatat aagcacagta gcaaactcat     1980



agatcgagtg tacaagggaa ttcccatgaa catccggggc ccggtgtggt cagtcctcct     2040



gaacattcag gaaatcaagt tgaaaaaccc cggaagatac cagatcatga aggagagggg     2100



caagaggtca tctgaacaca tccaccacat cgacctggac gtgaggacga ctctccggaa     2160



ccatgtcttc tttagggatc gatatggagc caagcagagg gaactattct acatcctcct     2220



ggcctattcg gagtataacc cggaggtggg ctactgcagg gacctgagcc acatcaccgc     2280



cttgttcctc ctttatctgc ctgaggagga cgcattctgg gcactggtgc agctgctggc     2340



cagtgagagg cactccctgc caggattcca cagcccaaat ggtgggacag tccaggggct     2400



ccaagaccaa caggagcatg tggtacccaa gtcacaaccc aagaccatgt ggcatcagga     2460



caaggaaggt ctatgcgggc agtgtgcctc gttaggctgc cttctccgga acctgattga     2520



cgggatctct ctcgggctca ccctgcgcct gtgggacgtg tatttggtgg aaggagaaca     2580



ggtgttgatg ccaataacca gcattgctct taaggttcag cagaagcgcc tcatgaagac     2640



atccaggtgt ggcctgtggg cacgtctgcg gaaccaattc ttcgatacct gggccatgaa     2700



cgatgacacc gtgctcaagc atcttagggc ctctacgaag aaactaacaa ggaagcaagg     2760



ggacctgcca cccccagcca aacgcgagca agggtccttg gcacccaggc ctgtgccggc     2820



ttcacgtggt gggaagaccc tctgcaaggg gtataggcag gcccctccag gcccaccagc     2880



ccagttccag cggcccattt gctcagcttc cccgccatgg gcatctcgtt tttccacgcc     2940



ctgtcctggt ggggctgtcc gggaagacac gtaccctgtg ggcactcagg gtgtgcccag     3000



cctggccctg gctcagggag gacctcaggg ttcctggaga ttcctggagt ggaagtcaat     3060



gccccggctc ccaacggacc tggatatagg gggcccttgg ttcccccatt atgattttga     3120



atggagctgc tgggtccgtg ccatatccca ggaggaccag ctggccacct gctggcaggc     3180



tgaacactgc ggagaggttc acaacaaaga tatgagttgg cctgaggaga tgtcttttac     3240



agcaaatagt agtaaaatag atagacaaaa ggttcccaca gaaaagggag ccacaggtct     3300



aagcaacctg ggaaacacat gcttcatgaa ctcaagcatc cagtgcgtta gtaacacaca     3360



gccactgaca cagtatttta tctcagggag acatctttat gaactcaaca ggacaaatcc     3420



cattggtatg aaggggcata tggctaaatg ctatggtgat ttagtgcagg aactctggag     3480



tggaactcag aagagtgttg ccccattaaa gcttcggcgg accatagcaa aatatgctcc     3540



caagtttgat gggtttcagc aacaagactc ccaagaactt ctggcttttc tcttggatgg     3600



tcttcatgaa gatctcaacc gagtccatga aaagccatat gtggaactga aggacagtga     3660



tggccgacca gactgggaag tagctgcaga ggcctgggac aaccatctaa gaagaaatag     3720



atcaattatt gtggatttgt tccatgggca gctaagatct caagtcaaat gcaagacatg     3780



tgggcatata agtgtccgat ttgacccttt caattttttg tctttgccac taccaatgga     3840



cagttacatg gacttagaaa taacagtgat taagttagat ggtactaccc ctgtacggta     3900



tggactaaga ctgaatatgg atgaaaagta cacaggttta aaaaaacagc tgagggatct     3960



ctgtggactt aattcagaac aaatcctact agcagaagta catgattcca acataaagaa     4020



ctttcctcag gataaccaaa aagtacaact ctcagtgagc ggatttttgt gtgcatttga     4080



aattcctgtc ccttcatctc caatttcagc ttctagtcca acacaaatag atttctcctc     4140



ttcaccatct acaaatggaa tgttcaccct aactaccaat ggggacctac ccaaaccaat     4200



attcatcccc aatggaatgc caaacactgt tgtgccatgt ggaactgaga agaacttcac     4260



aaatggaatg gttaatggtc acatgccatc tcttcctgac agccccttta caggttacat     4320



cattgcagtc caccgaaaaa tgatgaggac agaactgtat ttcctgtcac ctcaggagaa     4380



tcgccccagc ctctttggaa tgccattgat tgttccatgc actgtgcata cccggaagaa     4440



agacctatat gatgcggttt ggattcaagt atcctggtta gcaagaccac tcccacctca     4500



ggaagctagt attcatgccc aggatcgtga taactgtatg ggctatcaat atccattcac     4560



tctacgagtt gtgcagaaag atgggaactc ctgtgcttgg tgcccacagt atagattttg     4620



cagaggctgt aaaattgatt gtggggaaga cagagctttc attggaaatg cctatattgc     4680



tgtggattgg caccccacag cccttcacct tcgctatcaa acatcccagg aaagggttgt     4740



agataagcat gagagtgtgg agcagagtcg gcgagcgcaa gccgagccca tcaacctgga     4800



cagctgtctc cgtgctttca ccagtgagga agagctaggg gaaagtgaga tgtactactg     4860



ttccaagtgt aagacccact gcttagcaac aaagaagctg gatctctgga ggcttccacc     4920



cttcctgatt attcacctta agcgatttca atttgtaaat gatcagtgga taaaatcaca     4980



gaaaattgtc agatttcttc gggaaagttt tgatccgagt gcttttttgg taccacgaga     5040



cccggccctc tgccagcata aaccactcac accccagggg gatgagctct ccaagcccag     5100



gattctggca agagaggtga agaaagtgga tgcgcagagt tcggctggaa aagaggacat     5160



gctcctaagc aaaagcccat cctcactcag cgctaacatc agcagcagcc caaaaggttc     5220



tccttcttca tcaagaaaaa gtggaaccag ctgtccctcc agcaaaaaca gcagccctaa     5280



tagcagccca cggactttgg ggaggagcaa agggaggctc cggctgcccc agattggcag     5340



caaaaataag ccgtcaagta gtaagaagaa cttggatgcc agcaaagaga atggggctgg     5400



gcagatctgt gagctggctg acgccttgag ccgagggcat atgcgggggg gcagccaacc     5460



agagctggtc actcctcagg accatgaggt agctttggcc aatggattcc tttatgagca     5520



tgaagcatgt ggcaatggct gtggcgatgg ctacagcaat ggtcagcttg gaaaccacag     5580



tgaagaagac agcactgatg accaaagaga agacactcat attaagccta tttataatct     5640



atatgcaatt tcatgccatt caggaattct gagtgggggc cattacatca cttatgccaa     5700



aaacccaaac tgcaagtggt actgttataa tgacagcagc tgtgaggaac ttcaccctga     5760



tgaaattgac accgactctg cctacattct tttctatgag cagcagggga tagactacgc     5820



acaatttctg ccaaagattg atggcaaaaa gatggcagac acaagcagta cggatgaaga     5880



ctctgagtct gattacgaaa agtactctat gttacagtaa agctaccact ctggctgcta     5940



gacagcttgg tggcgaggga gatgactcct tgtagctgat acttggcaaa agtgtcactg     6000



aaagacaagc taaatgtagt tattttatcc tgttagaaca aaaattctaa ttaaaatagt     6060



taacttgaag agtagaaaca attgtatttt gaagtctcat acaagctgtc tgatagagaa     6120



ctttcaggca gatcccacca ttagcctgta aacaaaaggt gtggcaccag ccacctggga     6180



ccaaataaga attgaattgt gcttgtccag atatgaacaa atatgtagtg agtatagagt     6240



ttaccaataa tcataacaaa tattaaagat ttccttggag tcagaggaaa aaacaaacaa     6300



ttataatgtt gtctagggac gacatgatac gctacctcct ttttcctgaa gttttattcc     6360



attatattga caagatggag aaagcaagat catgaaggtg tgcaaatgat tcttacggca     6420



tggacaagga tttttcaatt tattttttaa actgtttcca taccctttct ttttcttgct     6480



ttttgttttt gccattgtgt ttacgtttga gacacaacca gtcattggtg gcaggggcat     6540



agagtggtca gtctgaaagg gaggctctct taagagctat gtgccttcca accagaggga     6600



gacccagtag aaagaaaaac atcctgggaa atccagctac cagggccctc ccagtggagg     6660



catcttacat ttaggctact tcaagtatcc tcagaaatgt attctgcacc cccggccccg     6720



cccatgctga gggaagggga gcagttgcca atatttgcac catcttcaca tgcacatgtt     6780



gcaacaagag cttctgggaa ggtaagcggc atcggagcta gatcacgttt cacaattagt     6840



ggttattctt ttctgtgttt gttttgcact ttaaaaaaga gagaacacat gcaaatgaac     6900



ttgcttgtgt gtatttgatg gctctaaggg ctataaatta caaacaaaac acatcccaga     6960



cattaggagt tcataagtat atttaatgaa attggtggtt ttaggaagtc aactttagtt     7020



ttgctttgtt tgcatgtcca ctggtttttt tattttgata tttgtctttt tttaaatttt     7080



acagtagtca ttgaaagtta tgtttctttg cttacttcat tttttccctc taattattta     7140



agattggaac aaaagtataa atattattta tttgaggtag aatttttttc atgtagtttc     7200



ttaatatata cttgaaggaa atgtttcacc ttatttttgg tctttgttta ttcatttaga     7260



ccctgcaagt tgattctcat tgccagattc cattaccctt tcttcctcat aggtagtaat     7320



taccaatgta actaagcatt tgtgttctga tatctgaggc cagtaactat taatatctag     7380



ttctcagagc atttggaaag gttatcttaa atggctacct aaattgaaat ccttttcaga     7440



aaaaatataa ttgcaagtag gtaggagtgg cctaaattgt ctaatgtaat aaagtcagac     7500



aaaatgcaca ctttatagtt tcaagatttt cagtaaataa aatctgtcca ttcctacctg     7560



gacatgtccc attaaaaagt ggaagatttt aaataatttc tttacagatg ttttatttaa     7620



acaggtagca caatctacta atgttgtgtg atttgtgtta tactggttgt aattaatttt     7680



tttaattcat gaactagcgg aaaatttatt aaattaacta ttaactacat tcaccttgta     7740



aattactgta taaaacttgt tgacaatgca ctgactttag aaagatgtta atgtacataa     7800



atagagtgta aataaaatag tgttgatgta ctgaaatatg aactgtatca aaagtattgg     7860



taattgtata tggggtgtac ctgtttatct gttaactatt atccaaacaa attaaatact     7920



gtggttgcct ctatgtgctg tttttcctca tacaagtaaa cacagaaagt c              7971





<210>  349

<211>  1406

<212>  PRT

<213>  Homo sapiens



<400>  349



Met Asp Met Val Glu Asn Ala Asp Ser Leu Gln Ala Gln Glu Arg Lys 

1               5                   10                  15      





Asp Ile Leu Met Lys Tyr Asp Lys Gly His Arg Ala Gly Leu Pro Glu 

            20                  25                  30          





Asp Lys Gly Pro Glu Pro Val Gly Ile Asn Ser Ser Ile Asp Arg Phe 

        35                  40                  45              





Gly Ile Leu His Glu Thr Glu Leu Pro Pro Val Thr Ala Arg Glu Ala 

    50                  55                  60                  





Lys Lys Ile Arg Arg Glu Met Thr Arg Thr Ser Lys Trp Met Glu Met 

65                  70                  75                  80  





Leu Gly Glu Trp Glu Thr Tyr Lys His Ser Ser Lys Leu Ile Asp Arg 

                85                  90                  95      





Val Tyr Lys Gly Ile Pro Met Asn Ile Arg Gly Pro Val Trp Ser Val 

            100                 105                 110         





Leu Leu Asn Ile Gln Glu Ile Lys Leu Lys Asn Pro Gly Arg Tyr Gln 

        115                 120                 125             





Ile Met Lys Glu Arg Gly Lys Arg Ser Ser Glu His Ile His His Ile 

    130                 135                 140                 





Asp Leu Asp Val Arg Thr Thr Leu Arg Asn His Val Phe Phe Arg Asp 

145                 150                 155                 160 





Arg Tyr Gly Ala Lys Gln Arg Glu Leu Phe Tyr Ile Leu Leu Ala Tyr 

                165                 170                 175     





Ser Glu Tyr Asn Pro Glu Val Gly Tyr Cys Arg Asp Leu Ser His Ile 

            180                 185                 190         





Thr Ala Leu Phe Leu Leu Tyr Leu Pro Glu Glu Asp Ala Phe Trp Ala 

        195                 200                 205             





Leu Val Gln Leu Leu Ala Ser Glu Arg His Ser Leu Pro Gly Phe His 

    210                 215                 220                 





Ser Pro Asn Gly Gly Thr Val Gln Gly Leu Gln Asp Gln Gln Glu His 

225                 230                 235                 240 





Val Val Pro Lys Ser Gln Pro Lys Thr Met Trp His Gln Asp Lys Glu 

                245                 250                 255     





Gly Leu Cys Gly Gln Cys Ala Ser Leu Gly Cys Leu Leu Arg Asn Leu 

            260                 265                 270         





Ile Asp Gly Ile Ser Leu Gly Leu Thr Leu Arg Leu Trp Asp Val Tyr 

        275                 280                 285             





Leu Val Glu Gly Glu Gln Val Leu Met Pro Ile Thr Ser Ile Ala Leu 

    290                 295                 300                 





Lys Val Gln Gln Lys Arg Leu Met Lys Thr Ser Arg Cys Gly Leu Trp 

305                 310                 315                 320 





Ala Arg Leu Arg Asn Gln Phe Phe Asp Thr Trp Ala Met Asn Asp Asp 

                325                 330                 335     





Thr Val Leu Lys His Leu Arg Ala Ser Thr Lys Lys Leu Thr Arg Lys 

            340                 345                 350         





Gln Gly Asp Leu Pro Pro Pro Ala Lys Arg Glu Gln Gly Ser Leu Ala 

        355                 360                 365             





Pro Arg Pro Val Pro Ala Ser Arg Gly Gly Lys Thr Leu Cys Lys Gly 

    370                 375                 380                 





Tyr Arg Gln Ala Pro Pro Gly Pro Pro Ala Gln Phe Gln Arg Pro Ile 

385                 390                 395                 400 





Cys Ser Ala Ser Pro Pro Trp Ala Ser Arg Phe Ser Thr Pro Cys Pro 

                405                 410                 415     





Gly Gly Ala Val Arg Glu Asp Thr Tyr Pro Val Gly Thr Gln Gly Val 

            420                 425                 430         





Pro Ser Leu Ala Leu Ala Gln Gly Gly Pro Gln Gly Ser Trp Arg Phe 

        435                 440                 445             





Leu Glu Trp Lys Ser Met Pro Arg Leu Pro Thr Asp Leu Asp Ile Gly 

    450                 455                 460                 





Gly Pro Trp Phe Pro His Tyr Asp Phe Glu Trp Ser Cys Trp Val Arg 

465                 470                 475                 480 





Ala Ile Ser Gln Glu Asp Gln Leu Ala Thr Cys Trp Gln Ala Glu His 

                485                 490                 495     





Cys Gly Glu Val His Asn Lys Asp Met Ser Trp Pro Glu Glu Met Ser 

            500                 505                 510         





Phe Thr Ala Asn Ser Ser Lys Ile Asp Arg Gln Lys Val Pro Thr Glu 

        515                 520                 525             





Lys Gly Ala Thr Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn 

    530                 535                 540                 





Ser Ser Ile Gln Cys Val Ser Asn Thr Gln Pro Leu Thr Gln Tyr Phe 

545                 550                 555                 560 





Ile Ser Gly Arg His Leu Tyr Glu Leu Asn Arg Thr Asn Pro Ile Gly 

                565                 570                 575     





Met Lys Gly His Met Ala Lys Cys Tyr Gly Asp Leu Val Gln Glu Leu 

            580                 585                 590         





Trp Ser Gly Thr Gln Lys Ser Val Ala Pro Leu Lys Leu Arg Arg Thr 

        595                 600                 605             





Ile Ala Lys Tyr Ala Pro Lys Phe Asp Gly Phe Gln Gln Gln Asp Ser 

    610                 615                 620                 





Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn 

625                 630                 635                 640 





Arg Val His Glu Lys Pro Tyr Val Glu Leu Lys Asp Ser Asp Gly Arg 

                645                 650                 655     





Pro Asp Trp Glu Val Ala Ala Glu Ala Trp Asp Asn His Leu Arg Arg 

            660                 665                 670         





Asn Arg Ser Ile Ile Val Asp Leu Phe His Gly Gln Leu Arg Ser Gln 

        675                 680                 685             





Val Lys Cys Lys Thr Cys Gly His Ile Ser Val Arg Phe Asp Pro Phe 

    690                 695                 700                 





Asn Phe Leu Ser Leu Pro Leu Pro Met Asp Ser Tyr Met Asp Leu Glu 

705                 710                 715                 720 





Ile Thr Val Ile Lys Leu Asp Gly Thr Thr Pro Val Arg Tyr Gly Leu 

                725                 730                 735     





Arg Leu Asn Met Asp Glu Lys Tyr Thr Gly Leu Lys Lys Gln Leu Arg 

            740                 745                 750         





Asp Leu Cys Gly Leu Asn Ser Glu Gln Ile Leu Leu Ala Glu Val His 

        755                 760                 765             





Asp Ser Asn Ile Lys Asn Phe Pro Gln Asp Asn Gln Lys Val Gln Leu 

    770                 775                 780                 





Ser Val Ser Gly Phe Leu Cys Ala Phe Glu Ile Pro Val Pro Ser Ser 

785                 790                 795                 800 





Pro Ile Ser Ala Ser Ser Pro Thr Gln Ile Asp Phe Ser Ser Ser Pro 

                805                 810                 815     





Ser Thr Asn Gly Met Phe Thr Leu Thr Thr Asn Gly Asp Leu Pro Lys 

            820                 825                 830         





Pro Ile Phe Ile Pro Asn Gly Met Pro Asn Thr Val Val Pro Cys Gly 

        835                 840                 845             





Thr Glu Lys Asn Phe Thr Asn Gly Met Val Asn Gly His Met Pro Ser 

    850                 855                 860                 





Leu Pro Asp Ser Pro Phe Thr Gly Tyr Ile Ile Ala Val His Arg Lys 

865                 870                 875                 880 





Met Met Arg Thr Glu Leu Tyr Phe Leu Ser Pro Gln Glu Asn Arg Pro 

                885                 890                 895     





Ser Leu Phe Gly Met Pro Leu Ile Val Pro Cys Thr Val His Thr Arg 

            900                 905                 910         





Lys Lys Asp Leu Tyr Asp Ala Val Trp Ile Gln Val Ser Trp Leu Ala 

        915                 920                 925             





Arg Pro Leu Pro Pro Gln Glu Ala Ser Ile His Ala Gln Asp Arg Asp 

    930                 935                 940                 





Asn Cys Met Gly Tyr Gln Tyr Pro Phe Thr Leu Arg Val Val Gln Lys 

945                 950                 955                 960 





Asp Gly Asn Ser Cys Ala Trp Cys Pro Gln Tyr Arg Phe Cys Arg Gly 

                965                 970                 975     





Cys Lys Ile Asp Cys Gly Glu Asp Arg Ala Phe Ile Gly Asn Ala Tyr 

            980                 985                 990         





Ile Ala Val Asp Trp His Pro Thr  Ala Leu His Leu Arg  Tyr Gln Thr 

        995                 1000                 1005             





Ser Gln  Glu Arg Val Val Asp  Lys His Glu Ser Val  Glu Gln Ser 

    1010                 1015                 1020             





Arg Arg  Ala Gln Ala Glu Pro  Ile Asn Leu Asp Ser  Cys Leu Arg 

    1025                 1030                 1035             





Ala Phe  Thr Ser Glu Glu Glu  Leu Gly Glu Ser Glu  Met Tyr Tyr 

    1040                 1045                 1050             





Cys Ser  Lys Cys Lys Thr His  Cys Leu Ala Thr Lys  Lys Leu Asp 

    1055                 1060                 1065             





Leu Trp  Arg Leu Pro Pro Phe  Leu Ile Ile His Leu  Lys Arg Phe 

    1070                 1075                 1080             





Gln Phe  Val Asn Asp Gln Trp  Ile Lys Ser Gln Lys  Ile Val Arg 

    1085                 1090                 1095             





Phe Leu  Arg Glu Ser Phe Asp  Pro Ser Ala Phe Leu  Val Pro Arg 

    1100                 1105                 1110             





Asp Pro  Ala Leu Cys Gln His  Lys Pro Leu Thr Pro  Gln Gly Asp 

    1115                 1120                 1125             





Glu Leu  Ser Lys Pro Arg Ile  Leu Ala Arg Glu Val  Lys Lys Val 

    1130                 1135                 1140             





Asp Ala  Gln Ser Ser Ala Gly  Lys Glu Asp Met Leu  Leu Ser Lys 

    1145                 1150                 1155             





Ser Pro  Ser Ser Leu Ser Ala  Asn Ile Ser Ser Ser  Pro Lys Gly 

    1160                 1165                 1170             





Ser Pro  Ser Ser Ser Arg Lys  Ser Gly Thr Ser Cys  Pro Ser Ser 

    1175                 1180                 1185             





Lys Asn  Ser Ser Pro Asn Ser  Ser Pro Arg Thr Leu  Gly Arg Ser 

    1190                 1195                 1200             





Lys Gly  Arg Leu Arg Leu Pro  Gln Ile Gly Ser Lys  Asn Lys Pro 

    1205                 1210                 1215             





Ser Ser  Ser Lys Lys Asn Leu  Asp Ala Ser Lys Glu  Asn Gly Ala 

    1220                 1225                 1230             





Gly Gln  Ile Cys Glu Leu Ala  Asp Ala Leu Ser Arg  Gly His Met 

    1235                 1240                 1245             





Arg Gly  Gly Ser Gln Pro Glu  Leu Val Thr Pro Gln  Asp His Glu 

    1250                 1255                 1260             





Val Ala  Leu Ala Asn Gly Phe  Leu Tyr Glu His Glu  Ala Cys Gly 

    1265                 1270                 1275             





Asn Gly  Cys Gly Asp Gly Tyr  Ser Asn Gly Gln Leu  Gly Asn His 

    1280                 1285                 1290             





Ser Glu  Glu Asp Ser Thr Asp  Asp Gln Arg Glu Asp  Thr His Ile 

    1295                 1300                 1305             





Lys Pro  Ile Tyr Asn Leu Tyr  Ala Ile Ser Cys His  Ser Gly Ile 

    1310                 1315                 1320             





Leu Ser  Gly Gly His Tyr Ile  Thr Tyr Ala Lys Asn  Pro Asn Cys 

    1325                 1330                 1335             





Lys Trp  Tyr Cys Tyr Asn Asp  Ser Ser Cys Glu Glu  Leu His Pro 

    1340                 1345                 1350             





Asp Glu  Ile Asp Thr Asp Ser  Ala Tyr Ile Leu Phe  Tyr Glu Gln 

    1355                 1360                 1365             





Gln Gly  Ile Asp Tyr Ala Gln  Phe Leu Pro Lys Ile  Asp Gly Lys 

    1370                 1375                 1380             





Lys Met  Ala Asp Thr Ser Ser  Thr Asp Glu Asp Ser  Glu Ser Asp 

    1385                 1390                 1395             





Tyr Glu  Lys Tyr Ser Met Leu  Gln 

    1400                 1405     





<210>  350

<211>  5984

<212>  DNA

<213>  Homo sapiens



<400>  350

cgcgctgtgt gtgtgtgtga gtggagagtg agtgcgggac ctgaggctgt gtgtgtgtga       60



actgtggcca ctggcggggt cggggggggg cagcggcgga gccgcctcgg acgataagga      120



aattgagatt tggagaagtt aaataaccaa gacttcacag gcaaagccat gactacagta      180



gtggtacatg tggactccaa agctgagctc actaccctgc tggagcagtg ggaaaaggaa      240



catggcagtg ggcaggacat ggtacctatc cttaccagga tgtctcaatt gattgaaaaa      300



gaaactgaag agtatcgtaa aggggatcca gacccatttg atgatcgaca tcctggtcga      360



gctgatccag agtgtatgct gggccacttg ctgagaatac tcttcaagaa tgatgatttc      420



atgaatgcac tggtgaatgc atatgtgatg acaagccgag agcccccttt aaacactgca      480



gcttgcagac tcctattaga catcatgcca gggctggaaa ctgctgtcgt ctttcaagaa      540



aaggagggaa ttgtcgagaa tcttttcaaa tgggcccgag aggccgatca accattgagg      600



acatattcta ctggactgtt aggaggtgct atggaaaatc aagacattgc tgccaactat      660



agagatgaaa attcacagct ggtggcaata gtgcttcgaa gactgaggga gctacagcta      720



caggaagtgg ctttgcggca ggaaaacaag cgtcccagtc cacggaagct ctcttctgaa      780



ccccttttgc ctctggatga ggaggctgtg gatatggact atggtgacat ggctgtagat      840



gtagtggatg gagaccaaga ggaagcttct ggagacatgg agatctcctt tcatcttgat      900



tcaggccaca agactagtag cagagtgaac tcaacaacca aacctgagga tggaggatta      960



aagaaaaaca agtcagcaaa acagggtgac agagagaact ttaggaaagc caagcaaaag     1020



ttgggtttct catcttctga tccagatcgc atgtttgttg agctgtctaa tagcagttgg     1080



tcagaaatgt ctccctgggt gattggcacc aattataccc tttatcctat gactcctgct     1140



atcgagcagc gactcattct ccaatatttg acccctctag gagaatatca ggagctactt     1200



cccatattca tgcaacttgg atcacgggag ctgatgatgt tctatattga cctgaagcaa     1260



actaatgatg tcctgcttac atttgaggca ctaaagcacc tagcatctct cctgctccat     1320



aacaaatttg ccacagaatt tgttgcgcat ggtggagtac agaaattact ggaaatacct     1380



cgtccttcta tggctgcaac cggtgtgtct atgtgtttgt attacctatc ctacaatcag     1440



gatgccatgg aaagagtttg catgcatccc cacaatgttc tgtctgatgt ggtgaactat     1500



accctgtggt taatggagtg ttctcatgct tcaggatgct gccatgctac catgtttttt     1560



tcaatttgct tctcatttcg ggccgtcttg gagctctttg accgctatga tggtcttcgt     1620



cgtctggtga acttgatcag tactttggag attctaaatt tggaagatca gggtgcactt     1680



ctgagtgatg atgaaatatt tgctagccgc caaactggga aacatacctg catggccttg     1740



cgcaaatact ttgaggctca cctggccatt aaattggaac aagtgaagca gtcacttcag     1800



aggactgagg gtggcattct tgtccaccca caacccccgt acaaggcatg ctcatatact     1860



catgaacaga ttgtggaaat gatggaattt ttgatagaat atggcccagc gcagctatat     1920



tgggaaccag ctgaagtttt cctcaaactt tcttgtgtgc aactcttgtt gcagcttatt     1980



tctattgcct gcaattggaa gacctattat gcaaggaatg acactgtgcg ctttgctttg     2040



gatgtcctgg ctattcttac tgtggtgcca aaaatccagc tccagttggc agaatcagtg     2100



gacgtgttgg atgaggctgg atctacagtc tctactgtag gtatcagcat tattttggga     2160



gtggctgagg gtgagttctt catccatgat gctgaaattc agaagtcagc acttcagatt     2220



atcatcaatt gtgtgtgtgg cccagataac cgaatatcca gtattggtaa atttatctct     2280



ggtactcctc ggagaaagct gcctcagaac cctaaaagca gtgagcacac cctggccaag     2340



atgtggaatg tggttcagtc caacaacggc atcaaggtgc tcctgtcctt actgtccatt     2400



aagatgccca tcacagatgc agaccaaatc cgggccctgg cctgcaaagc cctagtgggc     2460



ctgtctcgca gtagcactgt ccggcagatc atcagtaaac tgcccctttt cagcagctgc     2520



cagatccagc agctgatgaa ggagcctgtg ctgcaggaca agcgcagtga ccatgtcaag     2580



ttctgcaagt atgctgctga actcattgaa cgggtgtcag gaaaaccact tctcattggc     2640



actgatgttt ccctagcacg actgcagaaa gcagatgttg ttgcccagtc aaggatctcc     2700



ttccctgaga aagagctgct tttgttgata cgaaaccatc ttatttctaa agggcttgga     2760



gaaacagcaa ccgtgctgac aaaagaggct gacctgccca tgactgctgc ctcccattct     2820



tctgccttta ccccagtcac tgctgctgct tctcctgtct ctctaccccg aacccctcgt     2880



atcgctaatg gcattgcaac tcgtctgggc agccatgctg ctgtgggtgc ctctgcgcct     2940



tctgccccta ctgctcatcc tcagccacgg cccccccagg gtccgctagc tctgcccggc     3000



ccatcttatg caggcaactc ccctttgatt ggtagaatca gttttatcag agagaggcca     3060



tcaccctgca atggcaggaa aatcagagtg ttgcggcaga agtcggacca tggtgcctac     3120



agccaaagcc cagccataaa aaaacagctg gacagacatc ttccttcccc acctacgctg     3180



gacagtataa tcacagagta tcttagagaa caacatgctc gctgcaagaa tccagttgcc     3240



acctgcccac ctttctccct ctttactcct caccaatgtc ctgagccaaa acagaggcgg     3300



caagcgccaa taaactttac gtcaaggcta aaccgcaggg catcatttcc aaagtatgga     3360



ggggtggatg gcggatgctt tgataggcac cttatcttta gcagattccg tcctatttca     3420



gtgttccggg aagccaatga agatgagagt ggcttcacct gctgtgcatt ctcagcacgg     3480



gagcggttcc tgatgcttgg cacctgcaca gggcagctga agctctataa tgtgtttagt     3540



ggacaggagg aggccagcta taactgtcac aactcagcca tcacacatct tgaaccttcc     3600



agggatgggt ccttgctgct gacatctgct acttggagcc agcctttgtc tgcactttgg     3660



ggaatgaagt cagtatttga tatgaagcat tccttcacag aagatcacta tgttgagttc     3720



agtaagcact cccaggatcg ggtcatcggc acaaaaggag acattgccca catttatgat     3780



attcagactg gcaacaagct gttgactctg tttaacccag atcttgccaa caactacaag     3840



aggaactgtg ccacctttaa tcctacagat gatcttgtct taaatgatgg cgtcctctgg     3900



gatgtccgct ctgcacaggc catccacaag tttgacaagt tcaatatgaa catcagtggt     3960



gttttccatc caaatggact ggaggtgatc attaatactg agatttggga ccttcgaact     4020



tttcatcttt tgcatactgt tcccgctctg gatcagtgtc gcgtggtgtt caatcacacg     4080



ggaacagtga tgtatggagc tatgttgcag gcagatgatg aagatgactt aatggaagag     4140



aggatgaaaa gcccctttgg gtcatccttc cgaacattta atgcaactga ctacaaacct     4200



atagcaacca ttgatgtgaa acggaacatc tttgacctgt gtacagacac caaagactgc     4260



tatcttgctg tcattgagaa tcaaggcagc atggatgccc tgaacatgga cacagtatgc     4320



aggctgtatg aagtgggcag gcagcgtctg gcagaggatg aggatgaaga ggaggaccag     4380



gaagaggaag aacaggagga agaagatgat gatgaagatg atgatgacac cgatgattta     4440



gatgagcttg acactgacca gttgctggag gcggagttgg aggaggacga caataatgag     4500



aacgcagggg aagatgggga caatgacttc tctccctctg atgaggagct agcaaacctt     4560



ctagaggagg gagaggacgg ggaggatgaa gactctgatg cagatgagga ggtggaactg     4620



atcctggggg acactgacag ctctgacaac tctgatttgg aagatgacat catcttatct     4680



ctgaatgagt gaggagccat cactgcttgg aagagattct tggcagagag aagaggggac     4740



aaatttggtt gtgaagtaaa caagaaacac aagacggcta aaactctcca ggggcaggta     4800



aagccctgct gggctcagaa gcactataga atttgctgta cacactgaag tgggtctgtg     4860



tcacacaggt atttcttggt cctctggaga gcagaggact cactcagctc tttgcttcat     4920



gcctcgcttt aatggtagta aacacttaac cagtggaata gtctgactgc tggtactgat     4980



ggcatcagaa gaaaacaggt taacaatcaa gtagtgaaag cactatattc tagtcattaa     5040



ctcaacggag ccagtctcaa ctctgctggg agcacccaca ggtctctgtg ggggagacag     5100



ggactataac agggaggcag aattcaggtt ggcttgacaa cacaccttag gaacatgtgc     5160



taaggggcta aggaggcatc agctgtcttc cttattctac cagggctgaa aatcggagtc     5220



acttaggagg cagcatgaga acagtggcac accaccagtg aggcacatgt tgcctttttg     5280



tctttaagca acaccttaga cagggcctga accctgggtg ggggcactgg atgcctgaag     5340



taagtaagtt ttctcagtgg ggcagtctca taaaatcacc aggacattga ccacctgacc     5400



tcccctaact agtgctggcc aaggcctgag agttcacaga acctgctagg tcttaagagc     5460



caaaggaagg aagtggttga gggccaggaa agagaaggaa tgtcatgcca gggtgttact     5520



cctcaccaaa acttggcagt tctttttggg gccatgggac acctttctct gaagaggggt     5580



tggataaggc aaaggttgaa gtgtcttctc taggcacgtt ttctagcatg tttcctttta     5640



cttggttctg tctcacaaag ctgggaggta gatgattctt ccgggtcctg agcacctgct     5700



tcatgaagga agataggtag cccagagaag aagttttgga cttaacaaca taccaaggca     5760



gctctggcct gtgactcagg cgtttgttgg agagctgcag gaaaaccact gcagtgtgcc     5820



tgcaacagga caagacccac tcctgtttct ggcggtacca gctaccctgg aatggtggcg     5880



tgtcctgctg tacccaactg acttgcttag gtacctggca gctgtgacca cagctcaagt     5940



aaaaaaacaa aaacaggcaa ataaataaac atgcttaaca tgtc                      5984





<210>  351

<211>  1507

<212>  PRT

<213>  Homo sapiens



<400>  351



Met Thr Thr Val Val Val His Val Asp Ser Lys Ala Glu Leu Thr Thr 

1               5                   10                  15      





Leu Leu Glu Gln Trp Glu Lys Glu His Gly Ser Gly Gln Asp Met Val 

            20                  25                  30          





Pro Ile Leu Thr Arg Met Ser Gln Leu Ile Glu Lys Glu Thr Glu Glu 

        35                  40                  45              





Tyr Arg Lys Gly Asp Pro Asp Pro Phe Asp Asp Arg His Pro Gly Arg 

    50                  55                  60                  





Ala Asp Pro Glu Cys Met Leu Gly His Leu Leu Arg Ile Leu Phe Lys 

65                  70                  75                  80  





Asn Asp Asp Phe Met Asn Ala Leu Val Asn Ala Tyr Val Met Thr Ser 

                85                  90                  95      





Arg Glu Pro Pro Leu Asn Thr Ala Ala Cys Arg Leu Leu Leu Asp Ile 

            100                 105                 110         





Met Pro Gly Leu Glu Thr Ala Val Val Phe Gln Glu Lys Glu Gly Ile 

        115                 120                 125             





Val Glu Asn Leu Phe Lys Trp Ala Arg Glu Ala Asp Gln Pro Leu Arg 

    130                 135                 140                 





Thr Tyr Ser Thr Gly Leu Leu Gly Gly Ala Met Glu Asn Gln Asp Ile 

145                 150                 155                 160 





Ala Ala Asn Tyr Arg Asp Glu Asn Ser Gln Leu Val Ala Ile Val Leu 

                165                 170                 175     





Arg Arg Leu Arg Glu Leu Gln Leu Gln Glu Val Ala Leu Arg Gln Glu 

            180                 185                 190         





Asn Lys Arg Pro Ser Pro Arg Lys Leu Ser Ser Glu Pro Leu Leu Pro 

        195                 200                 205             





Leu Asp Glu Glu Ala Val Asp Met Asp Tyr Gly Asp Met Ala Val Asp 

    210                 215                 220                 





Val Val Asp Gly Asp Gln Glu Glu Ala Ser Gly Asp Met Glu Ile Ser 

225                 230                 235                 240 





Phe His Leu Asp Ser Gly His Lys Thr Ser Ser Arg Val Asn Ser Thr 

                245                 250                 255     





Thr Lys Pro Glu Asp Gly Gly Leu Lys Lys Asn Lys Ser Ala Lys Gln 

            260                 265                 270         





Gly Asp Arg Glu Asn Phe Arg Lys Ala Lys Gln Lys Leu Gly Phe Ser 

        275                 280                 285             





Ser Ser Asp Pro Asp Arg Met Phe Val Glu Leu Ser Asn Ser Ser Trp 

    290                 295                 300                 





Ser Glu Met Ser Pro Trp Val Ile Gly Thr Asn Tyr Thr Leu Tyr Pro 

305                 310                 315                 320 





Met Thr Pro Ala Ile Glu Gln Arg Leu Ile Leu Gln Tyr Leu Thr Pro 

                325                 330                 335     





Leu Gly Glu Tyr Gln Glu Leu Leu Pro Ile Phe Met Gln Leu Gly Ser 

            340                 345                 350         





Arg Glu Leu Met Met Phe Tyr Ile Asp Leu Lys Gln Thr Asn Asp Val 

        355                 360                 365             





Leu Leu Thr Phe Glu Ala Leu Lys His Leu Ala Ser Leu Leu Leu His 

    370                 375                 380                 





Asn Lys Phe Ala Thr Glu Phe Val Ala His Gly Gly Val Gln Lys Leu 

385                 390                 395                 400 





Leu Glu Ile Pro Arg Pro Ser Met Ala Ala Thr Gly Val Ser Met Cys 

                405                 410                 415     





Leu Tyr Tyr Leu Ser Tyr Asn Gln Asp Ala Met Glu Arg Val Cys Met 

            420                 425                 430         





His Pro His Asn Val Leu Ser Asp Val Val Asn Tyr Thr Leu Trp Leu 

        435                 440                 445             





Met Glu Cys Ser His Ala Ser Gly Cys Cys His Ala Thr Met Phe Phe 

    450                 455                 460                 





Ser Ile Cys Phe Ser Phe Arg Ala Val Leu Glu Leu Phe Asp Arg Tyr 

465                 470                 475                 480 





Asp Gly Leu Arg Arg Leu Val Asn Leu Ile Ser Thr Leu Glu Ile Leu 

                485                 490                 495     





Asn Leu Glu Asp Gln Gly Ala Leu Leu Ser Asp Asp Glu Ile Phe Ala 

            500                 505                 510         





Ser Arg Gln Thr Gly Lys His Thr Cys Met Ala Leu Arg Lys Tyr Phe 

        515                 520                 525             





Glu Ala His Leu Ala Ile Lys Leu Glu Gln Val Lys Gln Ser Leu Gln 

    530                 535                 540                 





Arg Thr Glu Gly Gly Ile Leu Val His Pro Gln Pro Pro Tyr Lys Ala 

545                 550                 555                 560 





Cys Ser Tyr Thr His Glu Gln Ile Val Glu Met Met Glu Phe Leu Ile 

                565                 570                 575     





Glu Tyr Gly Pro Ala Gln Leu Tyr Trp Glu Pro Ala Glu Val Phe Leu 

            580                 585                 590         





Lys Leu Ser Cys Val Gln Leu Leu Leu Gln Leu Ile Ser Ile Ala Cys 

        595                 600                 605             





Asn Trp Lys Thr Tyr Tyr Ala Arg Asn Asp Thr Val Arg Phe Ala Leu 

    610                 615                 620                 





Asp Val Leu Ala Ile Leu Thr Val Val Pro Lys Ile Gln Leu Gln Leu 

625                 630                 635                 640 





Ala Glu Ser Val Asp Val Leu Asp Glu Ala Gly Ser Thr Val Ser Thr 

                645                 650                 655     





Val Gly Ile Ser Ile Ile Leu Gly Val Ala Glu Gly Glu Phe Phe Ile 

            660                 665                 670         





His Asp Ala Glu Ile Gln Lys Ser Ala Leu Gln Ile Ile Ile Asn Cys 

        675                 680                 685             





Val Cys Gly Pro Asp Asn Arg Ile Ser Ser Ile Gly Lys Phe Ile Ser 

    690                 695                 700                 





Gly Thr Pro Arg Arg Lys Leu Pro Gln Asn Pro Lys Ser Ser Glu His 

705                 710                 715                 720 





Thr Leu Ala Lys Met Trp Asn Val Val Gln Ser Asn Asn Gly Ile Lys 

                725                 730                 735     





Val Leu Leu Ser Leu Leu Ser Ile Lys Met Pro Ile Thr Asp Ala Asp 

            740                 745                 750         





Gln Ile Arg Ala Leu Ala Cys Lys Ala Leu Val Gly Leu Ser Arg Ser 

        755                 760                 765             





Ser Thr Val Arg Gln Ile Ile Ser Lys Leu Pro Leu Phe Ser Ser Cys 

    770                 775                 780                 





Gln Ile Gln Gln Leu Met Lys Glu Pro Val Leu Gln Asp Lys Arg Ser 

785                 790                 795                 800 





Asp His Val Lys Phe Cys Lys Tyr Ala Ala Glu Leu Ile Glu Arg Val 

                805                 810                 815     





Ser Gly Lys Pro Leu Leu Ile Gly Thr Asp Val Ser Leu Ala Arg Leu 

            820                 825                 830         





Gln Lys Ala Asp Val Val Ala Gln Ser Arg Ile Ser Phe Pro Glu Lys 

        835                 840                 845             





Glu Leu Leu Leu Leu Ile Arg Asn His Leu Ile Ser Lys Gly Leu Gly 

    850                 855                 860                 





Glu Thr Ala Thr Val Leu Thr Lys Glu Ala Asp Leu Pro Met Thr Ala 

865                 870                 875                 880 





Ala Ser His Ser Ser Ala Phe Thr Pro Val Thr Ala Ala Ala Ser Pro 

                885                 890                 895     





Val Ser Leu Pro Arg Thr Pro Arg Ile Ala Asn Gly Ile Ala Thr Arg 

            900                 905                 910         





Leu Gly Ser His Ala Ala Val Gly Ala Ser Ala Pro Ser Ala Pro Thr 

        915                 920                 925             





Ala His Pro Gln Pro Arg Pro Pro Gln Gly Pro Leu Ala Leu Pro Gly 

    930                 935                 940                 





Pro Ser Tyr Ala Gly Asn Ser Pro Leu Ile Gly Arg Ile Ser Phe Ile 

945                 950                 955                 960 





Arg Glu Arg Pro Ser Pro Cys Asn Gly Arg Lys Ile Arg Val Leu Arg 

                965                 970                 975     





Gln Lys Ser Asp His Gly Ala Tyr Ser Gln Ser Pro Ala Ile Lys Lys 

            980                 985                 990         





Gln Leu Asp Arg His Leu Pro Ser  Pro Pro Thr Leu Asp  Ser Ile Ile 

        995                 1000                 1005             





Thr Glu  Tyr Leu Arg Glu Gln  His Ala Arg Cys Lys  Asn Pro Val 

    1010                 1015                 1020             





Ala Thr  Cys Pro Pro Phe Ser  Leu Phe Thr Pro His  Gln Cys Pro 

    1025                 1030                 1035             





Glu Pro  Lys Gln Arg Arg Gln  Ala Pro Ile Asn Phe  Thr Ser Arg 

    1040                 1045                 1050             





Leu Asn  Arg Arg Ala Ser Phe  Pro Lys Tyr Gly Gly  Val Asp Gly 

    1055                 1060                 1065             





Gly Cys  Phe Asp Arg His Leu  Ile Phe Ser Arg Phe  Arg Pro Ile 

    1070                 1075                 1080             





Ser Val  Phe Arg Glu Ala Asn  Glu Asp Glu Ser Gly  Phe Thr Cys 

    1085                 1090                 1095             





Cys Ala  Phe Ser Ala Arg Glu  Arg Phe Leu Met Leu  Gly Thr Cys 

    1100                 1105                 1110             





Thr Gly  Gln Leu Lys Leu Tyr  Asn Val Phe Ser Gly  Gln Glu Glu 

    1115                 1120                 1125             





Ala Ser  Tyr Asn Cys His Asn  Ser Ala Ile Thr His  Leu Glu Pro 

    1130                 1135                 1140             





Ser Arg  Asp Gly Ser Leu Leu  Leu Thr Ser Ala Thr  Trp Ser Gln 

    1145                 1150                 1155             





Pro Leu  Ser Ala Leu Trp Gly  Met Lys Ser Val Phe  Asp Met Lys 

    1160                 1165                 1170             





His Ser  Phe Thr Glu Asp His  Tyr Val Glu Phe Ser  Lys His Ser 

    1175                 1180                 1185             





Gln Asp  Arg Val Ile Gly Thr  Lys Gly Asp Ile Ala  His Ile Tyr 

    1190                 1195                 1200             





Asp Ile  Gln Thr Gly Asn Lys  Leu Leu Thr Leu Phe  Asn Pro Asp 

    1205                 1210                 1215             





Leu Ala  Asn Asn Tyr Lys Arg  Asn Cys Ala Thr Phe  Asn Pro Thr 

    1220                 1225                 1230             





Asp Asp  Leu Val Leu Asn Asp  Gly Val Leu Trp Asp  Val Arg Ser 

    1235                 1240                 1245             





Ala Gln  Ala Ile His Lys Phe  Asp Lys Phe Asn Met  Asn Ile Ser 

    1250                 1255                 1260             





Gly Val  Phe His Pro Asn Gly  Leu Glu Val Ile Ile  Asn Thr Glu 

    1265                 1270                 1275             





Ile Trp  Asp Leu Arg Thr Phe  His Leu Leu His Thr  Val Pro Ala 

    1280                 1285                 1290             





Leu Asp  Gln Cys Arg Val Val  Phe Asn His Thr Gly  Thr Val Met 

    1295                 1300                 1305             





Tyr Gly  Ala Met Leu Gln Ala  Asp Asp Glu Asp Asp  Leu Met Glu 

    1310                 1315                 1320             





Glu Arg  Met Lys Ser Pro Phe  Gly Ser Ser Phe Arg  Thr Phe Asn 

    1325                 1330                 1335             





Ala Thr  Asp Tyr Lys Pro Ile  Ala Thr Ile Asp Val  Lys Arg Asn 

    1340                 1345                 1350             





Ile Phe  Asp Leu Cys Thr Asp  Thr Lys Asp Cys Tyr  Leu Ala Val 

    1355                 1360                 1365             





Ile Glu  Asn Gln Gly Ser Met  Asp Ala Leu Asn Met  Asp Thr Val 

    1370                 1375                 1380             





Cys Arg  Leu Tyr Glu Val Gly  Arg Gln Arg Leu Ala  Glu Asp Glu 

    1385                 1390                 1395             





Asp Glu  Glu Glu Asp Gln Glu  Glu Glu Glu Gln Glu  Glu Glu Asp 

    1400                 1405                 1410             





Asp Asp  Glu Asp Asp Asp Asp  Thr Asp Asp Leu Asp  Glu Leu Asp 

    1415                 1420                 1425             





Thr Asp  Gln Leu Leu Glu Ala  Glu Leu Glu Glu Asp  Asp Asn Asn 

    1430                 1435                 1440             





Glu Asn  Ala Gly Glu Asp Gly  Asp Asn Asp Phe Ser  Pro Ser Asp 

    1445                 1450                 1455             





Glu Glu  Leu Ala Asn Leu Leu  Glu Glu Gly Glu Asp  Gly Glu Asp 

    1460                 1465                 1470             





Glu Asp  Ser Asp Ala Asp Glu  Glu Val Glu Leu Ile  Leu Gly Asp 

    1475                 1480                 1485             





Thr Asp  Ser Ser Asp Asn Ser  Asp Leu Glu Asp Asp  Ile Ile Leu 

    1490                 1495                 1500             





Ser Leu  Asn Glu 

    1505         





<210>  352

<211>  10302

<212>  DNA

<213>  Homo sapiens



<400>  352

gaagtgccgg agcggctgac agagcggctg acggagccgg gctcaccagg tcgctgccgc       60



gagggagttg ctgtgctggg gcctgggtgg cggctggagg cctgagttgg gctcgcggcg      120



ggggtcggca gggggccggg tggcggaatg atggaggagg aggaactgga gttcgtggag      180



gagctggaag ccgtgctgca gctcacgccc gaggtgcagc tggccatcga gcaggtgttt      240



ccaagccagg accctctaga tcgagcagat ttcaatgctg ttgagtatat caataccctg      300



ttcccaaccg agcaatctct ggcgaacata gacgaagtcg tgaacaaaat taggctgaaa      360



ataaggagac tggatgacaa tattcgaact gttgtaagag gtcagacgaa cgtggggcag      420



gatggacggc aagcgcttga agaggctcag aaagctatcc aacaactctt tggcaaaatc      480



aaagatatca aagacaaagc tgaaaaatca gagcaaatgg tgaaagaaat cacccgtgat      540



attaagcaat tagatcacgc caaacgccac ctgaccacct caatcaccac actgaaccac      600



ctgcacatgc tggcaggagg tgtcgactcc ctcgaagcca tgaccaggcg aagacaatac      660



ggagaagttg ctaatctcct tcagggtgtg atgaatgtcc tggagcactt ccacaagtat      720



atggggattc cgcagatccg gcagctttcc gaaagagtga aggctgcaca gactgagtta      780



ggacagcaaa tcctggcaga ttttgaagaa gcgtttcctt cccagggcac caagagacca      840



ggaggaccca gcaatgttct acgagatgca tgtctggttg ctaatattct agatcccagg      900



atcaaacagg aaatcatcaa aaagtttatt aaacagcatc tgtcagagta tctggtactt      960



tttcaagaaa accaagatgt tgcctggctg gacaaaatcg acagacgcta tgcctggata     1020



aaacgccagc ttgtggacta tgaggagaaa tacggccgca tgtttccacg tgagtggtgc     1080



atggctgaga ggattgcggt ggaattttgc catgtgacaa gggcagaact tgccaagatt     1140



atgcgtacca gagcgaagga aattgaagtg aaattgcttc tttttgctat tcaaagaaca     1200



actaactttg aggggtttct tgcaaaacgc ttctccggct gcaccctgac cgatgggacc     1260



ctgaaaaagc ttgagtctcc acccccatct accaatccct tcctggaaga tgagccaaca     1320



ccagagatgg aggaactggc aacggagaaa ggagatttag atcaaccaaa gaagcctaaa     1380



gccccagaca atccatttca tggcattgtt tccaagtgtt ttgagcctca tctctacgtg     1440



tatatcgaat cccaagacaa gaacctcgga gagctgatag atcggtttgt ggctgatttc     1500



aaagcccagg ggccacctaa gcccaacact gatgaagggg gtgccgtgct ccccagctgc     1560



gccgacctct ttgtctacta caagaagtgc atggtgcaat gctctcagct cagtactggg     1620



gagcccatga tcgccctgac caccattttc cagaagtacc tccgagaata cgcctggaaa     1680



atcctctctg gcaacctgcc caaaaccaca accagcagtg gaggactgac tatcagcagc     1740



ctcctcaagg aaaaggaggg ctcagaagta gccaagttca ctctggagga gctctgcctc     1800



atctgtaaca tcctgagcac ggcagagtac tgtctggcca ccacccagca gctagaagaa     1860



aaactcaaag aaaaagtgga tgtaagtctg attgaacgaa tcaatctgac tggagagatg     1920



gacacgttca gcaccgtcat ctccagcagt attcagctgc tggttcagga tctggatgct     1980



gcctgtgatc ctgccctgac tgccatgagc aagatgcagt ggcagaacgt ggagcacgtt     2040



ggtgaccaga gcccctacgt cacctctgtc attctgcaca tcaagcagaa cgtccccatc     2100



atccgtgaca acctggcttc cacacgcaag tacttcactc agttctgcgt taaatttgca     2160



aactccttca ttcccaaatt catcacccac ctcttcaagt gcaagccaat tagcatggtg     2220



ggagcagaac agctgctgct ggacacccac tcgctgaaga tggtcctgct cgatctcccc     2280



tccatcagct cgcaggtggt gaggaaggca cccgccagct acaccaagat cgttgtcaaa     2340



ggcatgaccc gggctgagat gatcctcaag gtagtgatgg cccctcatga accgttggtg     2400



gtgtttgttg acaactacat caaacttctc acagactgca acacagaaac ctttcagaag     2460



atactggaca tgaaggggct gaagaggagt gagcagagca gcatgctgga actcctgcgc     2520



cagcggctcc ccgcaccgcc ctcgggggca gaaagctccg gctcactgtc cctgacggcg     2580



ccaacaccag agcaagagtc gtcacgcatc cgcaagctcg agaaactcat taaaaagaga     2640



ctgtagcagc agcaaggggc cctttgctcc tggctggaga ccctcagcgc ccgttcccca     2700



gaagccccca acctctcctg tgctccccgg cactctcaca tcgtcggtct tcaaacttcc     2760



tgggacatgt gggttgttac tgagtctctc ccatgccctg tcttacttcc tgccctaatc     2820



ggagacgctg agtaagggct gggctctaag agggcgattt aggtgatctc tggttcgtga     2880



agcagaggca gcagtggagg ataggtccct gagctgccct tgactcatgt agcctcccca     2940



tggcagtcac accctcttga cacgtgggcc ccacccgtcc tttttttttt tttttttttt     3000



tttttttgag acagagtctc gctctgtcac ccaggctgga gtgcagtggc gtgatctcgg     3060



ctcactgcaa cctccgcctc ccaggttcaa gcaattctcc tgcctcagcc tcctgagtat     3120



cggattacag gcgtgagcca ccgagcccag ccccttcctc catttcttta ctcccaccct     3180



gctcctggtt tctagggaag ggaaaccagg aagttcactt ggaagacgtt tcctaggttt     3240



tctcatcaga tgaagccatg ggaacgccca ggaagtccat actctcaaac ccctttctgc     3300



ccactcacct tcaggtccac agcactttcc agcgtcatct gaaatagcaa aggtgatgtg     3360



cagcatccca gtgatgtgtt cctgtgttat gagaaggagt ctggggttct ggatgcctca     3420



ggaacagaat atggacctta aagaccaggc tgagagcctg gcctggcacg cagcctgccc     3480



gccccccccg cccttcctgt ccaccgcggg ctctctgcag cagggcttgc cgaagagact     3540



gctcccgacc tctcatgtca tcctgcatcc agagaatggc agcatatcaa gccgttaacc     3600



ctgattcact cggttccctt gaaaccaggc ctcagttaac catgaccaca gctacaggca     3660



aaccgctgct gttgctgcct gcttttgctg aagaatgata tcttgccagg cacggcggct     3720



catgcctgta gtcgcaacac tttgggagac caaggcagga ggatcacttg agtccaggag     3780



tttgagacca gcctgggcaa catacagatg tctacaaaaa taaaaatttg caaggtgtgg     3840



tggcatgcac ctgtagtccc aactgctagg gaggctgagg tgggcagatt gcttgagctc     3900



aggagtttga gaccagtctg ggcaacctgg caaaaccaaa aatacaaaaa attggctggg     3960



tgtggtggct catgcctgta atcacagcac tttgggaggc tgaggcaggt ggatcacctg     4020



aggtcaggaa ttcgagacca gcctgcccaa catggcgaaa ccctgtctca actaaaaata     4080



aaaaaaatta gccgggtgtc atggcgagtg cctgtaatcc cagctactgg ggaggctgag     4140



gcaggagaat cacttaaacc cgggaggtgg aggctgcagt gagccaagat ttcaccactg     4200



cactccagcc tgggtgacag agcaagaccc cttctcaaaa agttttcagg atagaggaaa     4260



tttccttaaa atccataaaa cttgtaacag ccgtacagta ggaataaggt ttggaaatct     4320



gcctggaaac ctgatttcct catccccacc ttgtttccca acataaccac tgctctgtgc     4380



ccctgccctc tctgccaggc tttctccccg atgccgtcca gctctgatcc tgagtgtcat     4440



ttcttcatcg gcttccaggc tgtccttgct agctggtttg actctcacgc atcaagcgtc     4500



tcaaatttga gaatgcggag gagaaaagaa gtgttgcgag aaggagatgc ggccttcagt     4560



tgaggtctat taggaaaaga ttccaaataa gacaagggcg gggggcggca gtcgggagag     4620



cccccaggaa gccctgtaga tgcccccacc ccagcccatg gagttgctat ggttaagcag     4680



cctgagccgt acagttgaaa aggggcggtg gggcccatct ccaaatagca cagccagttc     4740



agccgtctgt cctcaaccca ggagagctgg gaaagccagt ggactcctgc acctggttct     4800



tgtcactcct ggcgtttgtg tacagatcac cacttctctt tttggttcat tgttgaggag     4860



tcgttttccg gacggctcca tcacagcatt gagctatcaa gctgctgttt tccacagttg     4920



gtggtcacag ccagggaagt tgctgtcttg atttgttaca ttgtcagtaa tccccaagga     4980



accaatggat gtcagtagga gtttctgtta aatgtctcct tgatggggac tcagtactgt     5040



gtagagacgc tgtgtttctc ttctgggggt gtgcatcaga accactgggg ccttttaaaa     5100



tctacagatg ccggccgggc gccgtggctc acgcctggaa tcccagcact tggggaggct     5160



gaggcgggcg gatcacaagc gcaggaaatt gagaccatcc ttgccaatat ggtgaaaccc     5220



catctctaca aaaaatacaa aaattaccgg ggtgtggtgg cgtgcacacc tcccagctac     5280



ttgggaggct gaggcaggag aatcgcttga acccgggagg caaagattgc agtgagccga     5340



gatcacgcca ctgcactcca gcctggcgac agagtgagac tctatctcaa aacaaacaaa     5400



aaaacagatg cccggagatt ttgagtcagt aagtttggat ggggcctggc atacaggttt     5460



aaaagttcca taggtagtta taacgtttac accttgttaa gaaccactgc aacagagaga     5520



tttgctttat ggaagggctc ctgccacgca ttttcataca tgtctatttt tctgactcta     5580



agctaaaagt gcgccgacac tacacttgag ctggtgccaa cgtggtgaag attctctact     5640



gataacagct ttcattttaa acttgtgttg ggtcaggcgc ggtggctcac gcctgtaatc     5700



ccagcacttt gggaggccga ggtgggcgga tcacatgagg tcacgagttt gagaccagcc     5760



tggccaacat ggcaaaatcc catctctact aaaaatacaa aaaaaaaaaa aaaaaaagca     5820



ggcaggtggc gggtgcctgt aatcccagct acttgggagg ctgaggcagg ggaatcagtt     5880



gaatccggga ggcggaggtt gcagtgagcc gaggtcccgc cactgcactc cagcctggga     5940



gacagagtga gactcagtta aaaaaaaaag acttttggtg gtggtgggga ccatgcccag     6000



gattgggctc tctccatact gatgaggatt cttcttgttt tgatgaccaa cccccaagca     6060



gaagctttat ttattaacat cacttcaaaa ataacgtatc aaaggggcac cctaggccgg     6120



gtactgtggc atcacacctg taatgccagt gctttgagag gctgaggtgg gaagattgct     6180



tgagcccagg acttcaagac aagcctgggc aacagagtga gaccccatct ctattaaaaa     6240



ataggccggg catggtggct cacactggta atcccagcac tttgggaggc cgaggcaggt     6300



ggatcatgtg aggtcaggag ttcgagacca gcctggccga catggtgaaa ccctgtcttt     6360



actaaaaata caaaattagc caggcgtggt ggtgggcgcc tgtaatccca gctactcagg     6420



aggctgaagc aggaggatcg cttgaaccca ggaggcagag gctgcagtga gccgagatca     6480



tgccattgca ctcctgcctg ggtgacggag caagactctc taaaaaataa taaggtaaaa     6540



ggagtacctg tggatgaaag cagcagctaa cagctctgtg attcagctag acctagatat     6600



tgtgcccatt ccttcccctc agtccatttt ctgtagcccc tttaaaaacc aaaaaacaac     6660



tttgaagtca ctttgggttt aaaataaata gtggtaattt gtataatcaa taaagagttc     6720



actctgctct tactgagggg acttgtctga aagctggctt agcggtgtcc aggccagaga     6780



acatcctgtg tggactctta acaatgaaac aggagccgca atggacaagg tgttctgatc     6840



tccaaaccca gctcagggat tgaagctaac taccgccact ccttcctctc tcgaagaaca     6900



aagagccagt acccagggct ctgcccaccc ccgagaaggg gtgcctgatt tcttatgtct     6960



agggtggctc ctctgtgcag atcagacagg actgagagca gacaagctga gaccagcatg     7020



accagtacag ggcacgcaga gcgtgggggc aggtccgagg ctgctgctcg atgcagggta     7080



tgacaccaac ccttcctgaa ttgccatcgg atgaggagac ctggttccct gttgaaagaa     7140



tgccagggga aatgctgcat gtgcacagct ggaaatgggg ttccttctct aggaagagca     7200



ctcggaataa cctgctggaa atggggttcc ttccctagga agagcactca gaataacctg     7260



ctggaaatgg gattccttgg ctaggaagag cactcagaat aacctgctgg aaatgggatt     7320



ccttggctag gaagagcact cagaataacc tgctggaaat gggattcctt acctaggaag     7380



agcactcgga ataacctgct ggaaatggga ttccttacct aggaagagca ctcggaataa     7440



cctgctggaa atggggttcc ttccctagga agagcactcg gaataacctg ctggaaatgg     7500



ggttccttcc ctaggaagag cactcggaat aacctgctgg aaatggggtt ccttcgctag     7560



gaagagcact cggaataacc tgctggaaat gggattcctt cgctaggaag agcactcgga     7620



ataacctgct ggaaatggga ttccttcgct aggaagagca ctcggaataa cctgctggaa     7680



atgagattcc ttccctagga agagcactcg gaataacctg ctggaaatgg gattccttcg     7740



ctaggaagag cactcggaat aacctgctgg aaatgagatt ccttcgctag gaagagcact     7800



cggaataacc tgctggaaat gggattcctt cgctaggaag agcactcgga ataacctgct     7860



ggaaatgaga ttccttcgct aggaagagca ctcggaataa cctgctggaa atgggattcc     7920



ttcgctagga agagcactcg gaataacctg ctggaaatgg gattccttcg ctaggaagag     7980



cactcggaat aacctgctgg aaatgggatt ccttccctag gaagagcact cggaataacc     8040



tgctggaaat gagattcctt ccctaggaag agcactcgga ataacctgct ggaaatggga     8100



ttccttcgct aggaagagca ctcggaataa cctgctggaa atgggattcc ttcgctagga     8160



agagcactca gaacaacctg cctgcttgag ggtgacagca agtgtctcac acttctcgtc     8220



tactccaagt cagattccta aaaataaaat agagctccaa tgggcaattt aagcaaaagc     8280



cttagaaaca tggacacctg aaatgctggc ctacatgaag ggtacgatga cattttatat     8340



attaaataaa aattcccagt cctgttttag tattcatcag aatagcctct tggaccctcg     8400



aagttctaca cctttgggag atataaattt ccttaaaata aagggattgc ttctttgtgt     8460



aaatagcttt cattttctcc atctggaagt gatttctgcc tgcatgttgg agcacaaaat     8520



actgcagtta attaaagcat tactggatgt catttgctag aatgtatttc cttactgctg     8580



acagaaaaca gaacagactc taggaaagaa gtagcaagtc cgtgaccctg gccgctcctg     8640



gtggctgccc ttctcccttc cctgacagtc taaggaagca acgcgtggga gcagaatgtg     8700



gccgactgag cccagtcctg acctgcccag ttgcagtgga gcctgtctgt aatgttgtgt     8760



aaagtgtttt gcttctgact tggaacccta cttgccctgt gaatttctat cctgtgaacc     8820



ttcccttctc tgtccttacc gttcccatca cagcctgctc ttccagtgac ggccaagtga     8880



tttctctcct gcacgcatga gtccatcctg tttccttagt agctggatgg acgttttgcc     8940



atgaaaactc tttgggaagt cttgtgtcct ttagtgattt ctctcctgca cgcatgagtc     9000



catcctgttt ccttagtagc tggttggacg tttttgccat gaaaactctt cgggaagtcc     9060



tgtgtccttt caacagggga aaactggctg cggcccttcc attaggctcc aggatcatta     9120



cctcgtttcc attctttctt ttcaacagct ccccacttta ctagggaagc caagggatca     9180



acctaatgag aaaagaacct tccctgtagc ccacctggaa gggcattgcc tgccagctcc     9240



ttccttctca cctatgtgaa caggagggaa gatgccggcg atccatggat ctgtgggaca     9300



tgaaggacgt gtccatcaga aatgaaagca gcctgggatt ggaagcatcc acagaagact     9360



tgatctgcag gtcttgattt ggacctggca ctttgacacc aggcgagtca ctgatcccct     9420



gagcatccat tttcaatatt ggtgagaggg gattataatg aatattggct gtgaaggtca     9480



cacaagaccg ggctatatgc acttgctctg ccataaggca gtgtgaagtg tgttcgtgat     9540



cacttgtggg cgggagcctg tggctgtctt gcctggactg gcttttttaa acatggatga     9600



gtggtgacaa atcctgcggc cgtgtgcagg ctacatccgc agcgagctcc gcatatctgg     9660



tctttgcctt tttaggtcat gactgtaata tcaagcttac acgagagttt taaaagactg     9720



agcagtatcc ccttcccctg gcagctgctg cttccgtagc atttagggat aaacctgcag     9780



acactgagaa gagagcttcc tccctcctgg ggctggtggc gaggctgcct gttgtggaaa     9840



atagggcatg tctcctgtga atgcgaattg cgagggttgc caaagcctcc cttccaagaa     9900



acttgcttag gtgtctggtg tccacagacc agactcttct cccgacaggg acaaaaattc     9960



ttgcctgcct ttctttttct tttttttcct tttacttatt cttgcctttt ttcttcttct    10020



tcttctttag gtatgatgcc ccccaaaaaa ctaagcaaga ttaacttggg acaggcagtt    10080



ctaactggga agcctgagct cacaggctgt ttggattact ttccaattgt gtttcaaaga    10140



tgtttagact tttcccaagg ccagctgaat ccttataatc agcccaaaag ttcctttctg    10200



tttctgtctg tcccctttga gggtgttgac tcagagaacc tggggcaata tgagatgtta    10260



aaataaaaat agcgtccaac gtccaaaaaa aaaaaaaaaa aa                       10302





<210>  353

<211>  832

<212>  PRT

<213>  Homo sapiens



<400>  353



Met Met Glu Glu Glu Glu Leu Glu Phe Val Glu Glu Leu Glu Ala Val 

1               5                   10                  15      





Leu Gln Leu Thr Pro Glu Val Gln Leu Ala Ile Glu Gln Val Phe Pro 

            20                  25                  30          





Ser Gln Asp Pro Leu Asp Arg Ala Asp Phe Asn Ala Val Glu Tyr Ile 

        35                  40                  45              





Asn Thr Leu Phe Pro Thr Glu Gln Ser Leu Ala Asn Ile Asp Glu Val 

    50                  55                  60                  





Val Asn Lys Ile Arg Leu Lys Ile Arg Arg Leu Asp Asp Asn Ile Arg 

65                  70                  75                  80  





Thr Val Val Arg Gly Gln Thr Asn Val Gly Gln Asp Gly Arg Gln Ala 

                85                  90                  95      





Leu Glu Glu Ala Gln Lys Ala Ile Gln Gln Leu Phe Gly Lys Ile Lys 

            100                 105                 110         





Asp Ile Lys Asp Lys Ala Glu Lys Ser Glu Gln Met Val Lys Glu Ile 

        115                 120                 125             





Thr Arg Asp Ile Lys Gln Leu Asp His Ala Lys Arg His Leu Thr Thr 

    130                 135                 140                 





Ser Ile Thr Thr Leu Asn His Leu His Met Leu Ala Gly Gly Val Asp 

145                 150                 155                 160 





Ser Leu Glu Ala Met Thr Arg Arg Arg Gln Tyr Gly Glu Val Ala Asn 

                165                 170                 175     





Leu Leu Gln Gly Val Met Asn Val Leu Glu His Phe His Lys Tyr Met 

            180                 185                 190         





Gly Ile Pro Gln Ile Arg Gln Leu Ser Glu Arg Val Lys Ala Ala Gln 

        195                 200                 205             





Thr Glu Leu Gly Gln Gln Ile Leu Ala Asp Phe Glu Glu Ala Phe Pro 

    210                 215                 220                 





Ser Gln Gly Thr Lys Arg Pro Gly Gly Pro Ser Asn Val Leu Arg Asp 

225                 230                 235                 240 





Ala Cys Leu Val Ala Asn Ile Leu Asp Pro Arg Ile Lys Gln Glu Ile 

                245                 250                 255     





Ile Lys Lys Phe Ile Lys Gln His Leu Ser Glu Tyr Leu Val Leu Phe 

            260                 265                 270         





Gln Glu Asn Gln Asp Val Ala Trp Leu Asp Lys Ile Asp Arg Arg Tyr 

        275                 280                 285             





Ala Trp Ile Lys Arg Gln Leu Val Asp Tyr Glu Glu Lys Tyr Gly Arg 

    290                 295                 300                 





Met Phe Pro Arg Glu Trp Cys Met Ala Glu Arg Ile Ala Val Glu Phe 

305                 310                 315                 320 





Cys His Val Thr Arg Ala Glu Leu Ala Lys Ile Met Arg Thr Arg Ala 

                325                 330                 335     





Lys Glu Ile Glu Val Lys Leu Leu Leu Phe Ala Ile Gln Arg Thr Thr 

            340                 345                 350         





Asn Phe Glu Gly Phe Leu Ala Lys Arg Phe Ser Gly Cys Thr Leu Thr 

        355                 360                 365             





Asp Gly Thr Leu Lys Lys Leu Glu Ser Pro Pro Pro Ser Thr Asn Pro 

    370                 375                 380                 





Phe Leu Glu Asp Glu Pro Thr Pro Glu Met Glu Glu Leu Ala Thr Glu 

385                 390                 395                 400 





Lys Gly Asp Leu Asp Gln Pro Lys Lys Pro Lys Ala Pro Asp Asn Pro 

                405                 410                 415     





Phe His Gly Ile Val Ser Lys Cys Phe Glu Pro His Leu Tyr Val Tyr 

            420                 425                 430         





Ile Glu Ser Gln Asp Lys Asn Leu Gly Glu Leu Ile Asp Arg Phe Val 

        435                 440                 445             





Ala Asp Phe Lys Ala Gln Gly Pro Pro Lys Pro Asn Thr Asp Glu Gly 

    450                 455                 460                 





Gly Ala Val Leu Pro Ser Cys Ala Asp Leu Phe Val Tyr Tyr Lys Lys 

465                 470                 475                 480 





Cys Met Val Gln Cys Ser Gln Leu Ser Thr Gly Glu Pro Met Ile Ala 

                485                 490                 495     





Leu Thr Thr Ile Phe Gln Lys Tyr Leu Arg Glu Tyr Ala Trp Lys Ile 

            500                 505                 510         





Leu Ser Gly Asn Leu Pro Lys Thr Thr Thr Ser Ser Gly Gly Leu Thr 

        515                 520                 525             





Ile Ser Ser Leu Leu Lys Glu Lys Glu Gly Ser Glu Val Ala Lys Phe 

    530                 535                 540                 





Thr Leu Glu Glu Leu Cys Leu Ile Cys Asn Ile Leu Ser Thr Ala Glu 

545                 550                 555                 560 





Tyr Cys Leu Ala Thr Thr Gln Gln Leu Glu Glu Lys Leu Lys Glu Lys 

                565                 570                 575     





Val Asp Val Ser Leu Ile Glu Arg Ile Asn Leu Thr Gly Glu Met Asp 

            580                 585                 590         





Thr Phe Ser Thr Val Ile Ser Ser Ser Ile Gln Leu Leu Val Gln Asp 

        595                 600                 605             





Leu Asp Ala Ala Cys Asp Pro Ala Leu Thr Ala Met Ser Lys Met Gln 

    610                 615                 620                 





Trp Gln Asn Val Glu His Val Gly Asp Gln Ser Pro Tyr Val Thr Ser 

625                 630                 635                 640 





Val Ile Leu His Ile Lys Gln Asn Val Pro Ile Ile Arg Asp Asn Leu 

                645                 650                 655     





Ala Ser Thr Arg Lys Tyr Phe Thr Gln Phe Cys Val Lys Phe Ala Asn 

            660                 665                 670         





Ser Phe Ile Pro Lys Phe Ile Thr His Leu Phe Lys Cys Lys Pro Ile 

        675                 680                 685             





Ser Met Val Gly Ala Glu Gln Leu Leu Leu Asp Thr His Ser Leu Lys 

    690                 695                 700                 





Met Val Leu Leu Asp Leu Pro Ser Ile Ser Ser Gln Val Val Arg Lys 

705                 710                 715                 720 





Ala Pro Ala Ser Tyr Thr Lys Ile Val Val Lys Gly Met Thr Arg Ala 

                725                 730                 735     





Glu Met Ile Leu Lys Val Val Met Ala Pro His Glu Pro Leu Val Val 

            740                 745                 750         





Phe Val Asp Asn Tyr Ile Lys Leu Leu Thr Asp Cys Asn Thr Glu Thr 

        755                 760                 765             





Phe Gln Lys Ile Leu Asp Met Lys Gly Leu Lys Arg Ser Glu Gln Ser 

    770                 775                 780                 





Ser Met Leu Glu Leu Leu Arg Gln Arg Leu Pro Ala Pro Pro Ser Gly 

785                 790                 795                 800 





Ala Glu Ser Ser Gly Ser Leu Ser Leu Thr Ala Pro Thr Pro Glu Gln 

                805                 810                 815     





Glu Ser Ser Arg Ile Arg Lys Leu Glu Lys Leu Ile Lys Lys Arg Leu 

            820                 825                 830         





<210>  354

<211>  2694

<212>  DNA

<213>  Homo sapiens



<400>  354

gaagtgccgg agcggctgac agagcggctg acggagccgg gctcaccagg tcgctgccgc       60



gagggagttg ctgtgctggg gcctgggtgg cggctggagg cctgagttgg gctcgcggcg      120



ggggtcggca gggggccggg tggcggaatg atggaggagg aggaactgga gttcgtggag      180



gagctggaag ccgtgctgca gctcacgccc gaggtgcagc tggccatcga gcaggtgttt      240



ccaagccagg accctctaga tcgagcagat ttcaatgctg ttgagtatat caataccctg      300



ttcccaaccg agcaatctct ggcgaacata gacgaagtcg tgaacaaaat taggctgaaa      360



ataaggagac tggatgacaa tattcgaact gttgtaagag gtcagacgaa cgtggggcag      420



gatggacggc aagtgaaaga aatcacccgt gatattaagc aattagatca cgccaaacgc      480



cacctgacca cctcaatcac cacactgaac cacctgcaca tgctggcagg aggtgtcgac      540



tccctcgaag ccatgaccag gcgaagacaa tacggagaag ttgctaatct ccttcagggt      600



gtgatgaatg tcctggagca cttccacaag tatatgggga ttccgcagat ccggcagctt      660



tccgaaagag tgaaggctgc acagactgag ttaggacagc aaatcctggc agattttgaa      720



gaagcgtttc cttcccaggg caccaagaga ccaggaggac ccagcaatgt tctacgagat      780



gcatgtctgg ttgctaatat tctagatccc aggatcaaac aggaaatcat caaaaagttt      840



attaaacagc atctgtcaga gtatctggta ctttttcaag aaaaccaaga tgttgcctgg      900



ctggacaaaa tcgacagacg ctatgcctgg ataaaacgcc agcttgtgga ctatgaggag      960



aaatacggcc gcatgtttcc acgtgagtgg tgcatggctg agaggattgc ggtggaattt     1020



tgccatgtga caagggcaga acttgccaag attatgcgta ccagagcgaa ggaaattgaa     1080



gtgaaattgc ttctttttgc tattcaaaga acaactaact ttgaggggtt tcttgcaaaa     1140



cgcttctccg gctgcaccct gaccgatggg accctgaaaa agcttgagtc tccaccccca     1200



tctaccaatc ccttcctgga agatgagcca acaccagaga tggaggaact ggcaacggag     1260



aaaggagatt tagatcaacc aaagaagcct aaagccccag acaatccatt tcatggcatt     1320



gtttccaagt gttttgagcc tcatctctac gtgtatatcg aatcccaaga caagaacctc     1380



ggagagctga tagatcggtt tgtggctgat ttcaaagccc aggggccacc taagcccaac     1440



actgatgaag ggggtgccgt gctccccagc tgcgccgacc tctttgtcta ctacaagaag     1500



tgcatggtgc aatgctctca gctcagtact ggggagccca tgatcgccct gaccaccatt     1560



ttccagaagt acctccgaga atacgcctgg aaaatcctct ctggcaacct gcccaaaacc     1620



acaaccagca gtggaggact gactatcagc agcctcctca aggaaaagga gggctcagaa     1680



gtagccaagt tcactctgga ggagctctgc ctcatctgta acatcctgag cacggcagag     1740



tactgtctgg ccaccaccca gcagctagaa gaaaaactca aagaaaaagt ggatgtaagt     1800



ctgattgaac gaatcaatct gactggagag atggacacgt tcagcaccgt catctccagc     1860



agtattcagc tgctggttca ggatctggat gctgcctgtg atcctgccct gactgccatg     1920



agcaagatgc agtggcagaa cgtggagcac gttggtgacc agagccccta cgtcacctct     1980



gtcattctgc acatcaagca gaacgtcccc atcatccgtg acaacctggc ttccacacgc     2040



aagtacttca ctcagttctg cgttaaattt gcaaactcct tcattcccaa attcatcacc     2100



cacctcttca agtgcaagcc aattagcatg gtgggagcag aacaggtgag atggacgtag     2160



tatcaggcat ttgcctggca gcttttgttg tagatcaagc acatattctt ctagtccaga     2220



tctacttggc aggaataaaa ttgatgatgt cccctgtttg gggacagtat aatgactcac     2280



ccggaaggtt tcttaattcg ttcttccatt tatttttaaa aattttgttt gaacgcctac     2340



taagttctgg gtgcagggta taacacagca agcaccatgg aaaggtccct gctcctagtg     2400



ctcacactcc aataagaaga agtggctggg ccgggcacag cggctcacgc tgtaacccca     2460



gcatttcggg aggcctgggc aggcagatca cctggggtaa ggaatttgag agcagcctgg     2520



ccaacatggt gaaatcccat ctctactaaa aatacaaaaa ttagctgggc atgggggcag     2580



gctactgggg aggctgaggc aggagaatca cttgaacccg ggaggtggag gttgcagtga     2640



gccgatatca caccactgca ctccagcctg ggtgacaaag tgagactcca tctc           2694





<210>  355

<211>  670

<212>  PRT

<213>  Homo sapiens



<400>  355



Met Met Glu Glu Glu Glu Leu Glu Phe Val Glu Glu Leu Glu Ala Val 

1               5                   10                  15      





Leu Gln Leu Thr Pro Glu Val Gln Leu Ala Ile Glu Gln Val Phe Pro 

            20                  25                  30          





Ser Gln Asp Pro Leu Asp Arg Ala Asp Phe Asn Ala Val Glu Tyr Ile 

        35                  40                  45              





Asn Thr Leu Phe Pro Thr Glu Gln Ser Leu Ala Asn Ile Asp Glu Val 

    50                  55                  60                  





Val Asn Lys Ile Arg Leu Lys Ile Arg Arg Leu Asp Asp Asn Ile Arg 

65                  70                  75                  80  





Thr Val Val Arg Gly Gln Thr Asn Val Gly Gln Asp Gly Arg Gln Val 

                85                  90                  95      





Lys Glu Ile Thr Arg Asp Ile Lys Gln Leu Asp His Ala Lys Arg His 

            100                 105                 110         





Leu Thr Thr Ser Ile Thr Thr Leu Asn His Leu His Met Leu Ala Gly 

        115                 120                 125             





Gly Val Asp Ser Leu Glu Ala Met Thr Arg Arg Arg Gln Tyr Gly Glu 

    130                 135                 140                 





Val Ala Asn Leu Leu Gln Gly Val Met Asn Val Leu Glu His Phe His 

145                 150                 155                 160 





Lys Tyr Met Gly Ile Pro Gln Ile Arg Gln Leu Ser Glu Arg Val Lys 

                165                 170                 175     





Ala Ala Gln Thr Glu Leu Gly Gln Gln Ile Leu Ala Asp Phe Glu Glu 

            180                 185                 190         





Ala Phe Pro Ser Gln Gly Thr Lys Arg Pro Gly Gly Pro Ser Asn Val 

        195                 200                 205             





Leu Arg Asp Ala Cys Leu Val Ala Asn Ile Leu Asp Pro Arg Ile Lys 

    210                 215                 220                 





Gln Glu Ile Ile Lys Lys Phe Ile Lys Gln His Leu Ser Glu Tyr Leu 

225                 230                 235                 240 





Val Leu Phe Gln Glu Asn Gln Asp Val Ala Trp Leu Asp Lys Ile Asp 

                245                 250                 255     





Arg Arg Tyr Ala Trp Ile Lys Arg Gln Leu Val Asp Tyr Glu Glu Lys 

            260                 265                 270         





Tyr Gly Arg Met Phe Pro Arg Glu Trp Cys Met Ala Glu Arg Ile Ala 

        275                 280                 285             





Val Glu Phe Cys His Val Thr Arg Ala Glu Leu Ala Lys Ile Met Arg 

    290                 295                 300                 





Thr Arg Ala Lys Glu Ile Glu Val Lys Leu Leu Leu Phe Ala Ile Gln 

305                 310                 315                 320 





Arg Thr Thr Asn Phe Glu Gly Phe Leu Ala Lys Arg Phe Ser Gly Cys 

                325                 330                 335     





Thr Leu Thr Asp Gly Thr Leu Lys Lys Leu Glu Ser Pro Pro Pro Ser 

            340                 345                 350         





Thr Asn Pro Phe Leu Glu Asp Glu Pro Thr Pro Glu Met Glu Glu Leu 

        355                 360                 365             





Ala Thr Glu Lys Gly Asp Leu Asp Gln Pro Lys Lys Pro Lys Ala Pro 

    370                 375                 380                 





Asp Asn Pro Phe His Gly Ile Val Ser Lys Cys Phe Glu Pro His Leu 

385                 390                 395                 400 





Tyr Val Tyr Ile Glu Ser Gln Asp Lys Asn Leu Gly Glu Leu Ile Asp 

                405                 410                 415     





Arg Phe Val Ala Asp Phe Lys Ala Gln Gly Pro Pro Lys Pro Asn Thr 

            420                 425                 430         





Asp Glu Gly Gly Ala Val Leu Pro Ser Cys Ala Asp Leu Phe Val Tyr 

        435                 440                 445             





Tyr Lys Lys Cys Met Val Gln Cys Ser Gln Leu Ser Thr Gly Glu Pro 

    450                 455                 460                 





Met Ile Ala Leu Thr Thr Ile Phe Gln Lys Tyr Leu Arg Glu Tyr Ala 

465                 470                 475                 480 





Trp Lys Ile Leu Ser Gly Asn Leu Pro Lys Thr Thr Thr Ser Ser Gly 

                485                 490                 495     





Gly Leu Thr Ile Ser Ser Leu Leu Lys Glu Lys Glu Gly Ser Glu Val 

            500                 505                 510         





Ala Lys Phe Thr Leu Glu Glu Leu Cys Leu Ile Cys Asn Ile Leu Ser 

        515                 520                 525             





Thr Ala Glu Tyr Cys Leu Ala Thr Thr Gln Gln Leu Glu Glu Lys Leu 

    530                 535                 540                 





Lys Glu Lys Val Asp Val Ser Leu Ile Glu Arg Ile Asn Leu Thr Gly 

545                 550                 555                 560 





Glu Met Asp Thr Phe Ser Thr Val Ile Ser Ser Ser Ile Gln Leu Leu 

                565                 570                 575     





Val Gln Asp Leu Asp Ala Ala Cys Asp Pro Ala Leu Thr Ala Met Ser 

            580                 585                 590         





Lys Met Gln Trp Gln Asn Val Glu His Val Gly Asp Gln Ser Pro Tyr 

        595                 600                 605             





Val Thr Ser Val Ile Leu His Ile Lys Gln Asn Val Pro Ile Ile Arg 

    610                 615                 620                 





Asp Asn Leu Ala Ser Thr Arg Lys Tyr Phe Thr Gln Phe Cys Val Lys 

625                 630                 635                 640 





Phe Ala Asn Ser Phe Ile Pro Lys Phe Ile Thr His Leu Phe Lys Cys 

                645                 650                 655     





Lys Pro Ile Ser Met Val Gly Ala Glu Gln Val Arg Trp Thr 

            660                 665                 670 





<210>  356

<211>  2284

<212>  DNA

<213>  Homo sapiens



<400>  356

gcggtgccgc ccgccgtggc cgcctcagcc caccagccgg gaccgcgagc catgctgtcc       60



gccgcccgcc cccagggttg ttaaagccag actgcgaact ctcgccactg ccgccaccgc      120



cgcgtcccgt cccaccgtcg cgggcaacaa ccaaagtcgc cgcaactgca gcacagagcg      180



ggcaaagcca ggcaggccat ggggctctgg gcgctgttgc ctggctgggt ttctgctacg      240



ctgctgctgg cgctggccgc tctgcccgca gccctggctg ccaacagcag tggccgatgg      300



tggggtattg tgaacgtagc ctcctccacg aacctgctta cagactccaa gagtctgcaa      360



ctggtactcg agcccagtct gcagctgttg agccgcaaac agcggcgtct gatacgccaa      420



aatccgggga tcctgcacag cgtgagtggg gggctgcaga gtgccgtgcg cgagtgcaag      480



tggcagttcc ggaatcgccg ctggaactgt cccactgctc cagggcccca cctcttcggc      540



aagatcgtca accgaggctg tcgagaaacg gcgtttatct tcgctatcac ctccgccggg      600



gtcacccatt cggtggcgcg ctcctgctca gaaggttcca tcgaatcctg cacgtgtgac      660



taccggcggc gcggccccgg gggccccgac tggcactggg ggggctgcag cgacaacatt      720



gacttcggcc gcctcttcgg ccgggagttc gtggactccg gggagaaggg gcgggacctg      780



cgcttcctca tgaaccttca caacaacgag gcaggccgta cgaccgtatt ctccgagatg      840



cgccaggagt gcaagtgcca cgggatgtcc ggctcatgca cggtgcgcac gtgctggatg      900



cggctgccca cgctgcgcgc cgtgggcgat gtgctgcgcg accgcttcga cggcgcctcg      960



cgcgtcctgt acggcaaccg cggcagcaac cgcgcttcgc gggcggagct gctgcgcctg     1020



gagccggaag acccggccca caaaccgccc tccccccacg acctcgtcta cttcgagaaa     1080



tcgcccaact tctgcacgta cagcggacgc ctgggcacag caggcacggc agggcgcgcc     1140



tgtaacagct cgtcgcccgc gctggacggc tgcgagctgc tctgctgcgg caggggccac     1200



cgcacgcgca cgcagcgcgt caccgagcgc tgcaactgca ccttccactg gtgctgccac     1260



gtcagctgcc gcaactgcac gcacacgcgc gtactgcacg agtgtctgtg aggcgctgcg     1320



cggactcgcc cccaggaacg ctctcctcga gccctccccc aaacagactc gctagcactc     1380



aagacccggt tattcgccca cccgagtacc tccagtcaca ctccccgcgg ttcatacgca     1440



tcccatctct cccacttcct cctacctggg gactcctcaa accacttgcc tggggcggca     1500



tgaaccctct tgccatcctg atggacctgc cccggaccta cctccctccc tctccgcggg     1560



agaccccttg ttgcactgcc ccctgcttgg ccaggaggtg agagaaggat gggtcccctc     1620



cgccatgggg tcggctcctg atggtgtcat tctgcctgct ccatcgcgcc agcgacctct     1680



ctgcctctct tcttcccctt tgtcctgcgt tttctccggg tcctcctaag tcccttccta     1740



ttctcctgcc atgggtgcag accctgaacc cacacctggg catcagggcc tttctcctcc     1800



ccacctgtag ctgaagcagg aggttacagg gcaaaagggc agctgtgatg atgtggaaat     1860



gaggttgggg gaaccagcag aaatgccccc attctcccag tctctgtcgt ggagccattg     1920



aacagctgtg agccatgcct ccctgggcca cctcctaccc cttcctgtcc tgcctcctca     1980



tcagtgtgta aataatttgc actgaaacgt ggatacagag ccacgagttt ggatgttgta     2040



aataaaacta tttattgtgc tgggtcccag cctggtttgc aaagaccacc tccaacccaa     2100



cccaatccct ctccactctt ctctcctttc tccctgcagc cttttctggt ccctcttctc     2160



tcctcagttt ctcaaagatg cgtttgcctc ctggaatcag tatttccttc cactgtagct     2220



attagcggct cctcgccccc accagtgtag catcttcctc tgcagaataa aatctctatt     2280



ttta                                                                  2284





<210>  357

<211>  370

<212>  PRT

<213>  Homo sapiens



<400>  357



Met Gly Leu Trp Ala Leu Leu Pro Gly Trp Val Ser Ala Thr Leu Leu 

1               5                   10                  15      





Leu Ala Leu Ala Ala Leu Pro Ala Ala Leu Ala Ala Asn Ser Ser Gly 

            20                  25                  30          





Arg Trp Trp Gly Ile Val Asn Val Ala Ser Ser Thr Asn Leu Leu Thr 

        35                  40                  45              





Asp Ser Lys Ser Leu Gln Leu Val Leu Glu Pro Ser Leu Gln Leu Leu 

    50                  55                  60                  





Ser Arg Lys Gln Arg Arg Leu Ile Arg Gln Asn Pro Gly Ile Leu His 

65                  70                  75                  80  





Ser Val Ser Gly Gly Leu Gln Ser Ala Val Arg Glu Cys Lys Trp Gln 

                85                  90                  95      





Phe Arg Asn Arg Arg Trp Asn Cys Pro Thr Ala Pro Gly Pro His Leu 

            100                 105                 110         





Phe Gly Lys Ile Val Asn Arg Gly Cys Arg Glu Thr Ala Phe Ile Phe 

        115                 120                 125             





Ala Ile Thr Ser Ala Gly Val Thr His Ser Val Ala Arg Ser Cys Ser 

    130                 135                 140                 





Glu Gly Ser Ile Glu Ser Cys Thr Cys Asp Tyr Arg Arg Arg Gly Pro 

145                 150                 155                 160 





Gly Gly Pro Asp Trp His Trp Gly Gly Cys Ser Asp Asn Ile Asp Phe 

                165                 170                 175     





Gly Arg Leu Phe Gly Arg Glu Phe Val Asp Ser Gly Glu Lys Gly Arg 

            180                 185                 190         





Asp Leu Arg Phe Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Thr 

        195                 200                 205             





Thr Val Phe Ser Glu Met Arg Gln Glu Cys Lys Cys His Gly Met Ser 

    210                 215                 220                 





Gly Ser Cys Thr Val Arg Thr Cys Trp Met Arg Leu Pro Thr Leu Arg 

225                 230                 235                 240 





Ala Val Gly Asp Val Leu Arg Asp Arg Phe Asp Gly Ala Ser Arg Val 

                245                 250                 255     





Leu Tyr Gly Asn Arg Gly Ser Asn Arg Ala Ser Arg Ala Glu Leu Leu 

            260                 265                 270         





Arg Leu Glu Pro Glu Asp Pro Ala His Lys Pro Pro Ser Pro His Asp 

        275                 280                 285             





Leu Val Tyr Phe Glu Lys Ser Pro Asn Phe Cys Thr Tyr Ser Gly Arg 

    290                 295                 300                 





Leu Gly Thr Ala Gly Thr Ala Gly Arg Ala Cys Asn Ser Ser Ser Pro 

305                 310                 315                 320 





Ala Leu Asp Gly Cys Glu Leu Leu Cys Cys Gly Arg Gly His Arg Thr 

                325                 330                 335     





Arg Thr Gln Arg Val Thr Glu Arg Cys Asn Cys Thr Phe His Trp Cys 

            340                 345                 350         





Cys His Val Ser Cys Arg Asn Cys Thr His Thr Arg Val Leu His Glu 

        355                 360                 365             





Cys Leu 

    370 





<210>  358

<211>  6301

<212>  DNA

<213>  Homo sapiens



<400>  358

tatcaatggc gcaggcttca cttctgctgt ggcggtgact gaggcctttc tggtgacctc       60



agcccaacac aggccgtctc cggagcttcc cggtagtggc cccggattcc cacggtcttt      120



gtcattggct gtcagctagc aggcctggcc gctcccgtgc ggagagacca tctcttcagg      180



gcaatgtcca ggccgagcag cgtctccccg cggcagccgg ctcctggcgg tggcggaggc      240



ggcggcccct cgccttgtgg ccctgggggc ggcggccggg ccaaggggct gaaggacatt      300



cgcattgatg aggaggtgaa gatcgcagtc aatatcgcgc tggagcgctt ccgatacggg      360



gaccagagag aaatggaatt tccttcttct ttgaccagta ctgaaagagc ctttattcat      420



cgactcagtc agtctcttgg tttggtctct aaaagtaaag gaaagggagc aaatagatac      480



ctaactgtga agaagaaaga tggatcagaa acagctcatg caatgatgac ctgtaatttg      540



actcataata caaaacatgc tgttaggagc ctaattcaaa gatttcctgt caccaataaa      600



gagcgtacag aacttctgcc taaaacagaa agaggaaatg tgtttgcagt tgaagctgaa      660



aaccgggaaa tgagcaagac aagtgggcga ctcaacaatg gcatacctca gattccagtg      720



aaaagaggag aatccgaatt tgattctttt aggcagtctt taccagtgtt tgagaaacag      780



gaagaaattg ttaaaataat taaggaaaat aaagtagttt tgattgtagg agaaactggg      840



tctggaaaga ccacacagat tcctcagttc cttttagatg attgctttaa aaatggtatc      900



ccctgccgta tattttgtac tcaaccaaga cgattggcag ctatcgctgt ggctgaaaga      960



gttgccgcag agagacggga aaggattggt caaacaattg gttatcagat ccgattagaa     1020



agcagggttt ctccaaagac acttctgaca ttttgtacta atggggtatt gcttcgtaca     1080



ttgatggcag gagatagtac gttgtcgact gtgacacatg ttatcgtgga tgaagtgcat     1140



gaaagggatc gatttagtga ttttttactt acaaagttaa gagatttgtt gcaaaagcac     1200



ccaactttga aactaattct ttctagtgct gccttggatg taaatctctt tataagatat     1260



tttggaagtt gtccagtgat atatatacag ggaagaccat ttgaagtaaa agaaatgttt     1320



ctggaagata ttttaagaac aactggatat acaaacaaag aaatgttaaa atataaaaag     1380



gaaaaacagc aagaagagaa acaacaaacc acacttacag aatggtactc agctcaagaa     1440



aatagtttca agcctgaatc tcagaggcag agaactgttc taaatgtgac tgatgagtat     1500



gacttactgg atgatggtgg tgatgctgtc ttcagtcagc tgactgaaaa agatgtgaat     1560



tgccttgaac catggttaat aaaggaaatg gatgcttgcc tttctgatat atggctacat     1620



aaagatattg atgcctttgc tcaggtcttt catctcattt taactgaaaa tgttagtgtt     1680



gattacagac atagtgaaac cagtgcaaca gctctgatgg ttgctgcagg acgtggcttt     1740



gcaagtcaag tagaacagtt aatcagtatg ggagccaatg tccatagtaa agcatcaaat     1800



ggctggatgg cattggattg ggctaaacac tttgggcaga ctgaaattgt ggatcttcta     1860



gaatcttaca gtgcttcact ggaatttgga aatctagatg aaagttctct ggttcaaaca     1920



aatggaagtg acctcagtgc tgaagacaga gagctcctga aagcttatca tcatagtttc     1980



gatgatgaaa aagtagactt ggatttgatc atgcatcttc tatacaatat ctgccatagt     2040



tgtgatgctg gtgcagtact aatttttctg cctggatatg acgaaattgt tggactgaga     2100



gatcgcatcc tgtttgatga caagcggttt gctgacaata cacatagata ccaagtcttt     2160



atgcttcatt caaatatgca aacatccgat caaaagaaag tattaaaaaa cccacctgca     2220



ggtgttcgaa aaataattct ttccaccaat attgctgaaa ccagcatcac agtcaatgat     2280



gttgtctttg ttattgattc tggtaaggtg aaagagaaat cctttgatgc tctgaatttt     2340



gttacaatgt taaaaatggt atggatttcc aaagctagtg ccatacagcg gaaaggcagg     2400



gcagggcgat gtagacctgg aatttgtttt cgtctgttca gtagactccg attccagaat     2460



atgttggaat ttcagactcc ggaacttttg agaatgccat tacaggaact ttgcttacat     2520



accaagctgt tagccccagt taattgtccc attgctgatt ttcttatgaa agctcctgaa     2580



cctccaccag ctttaattgt aagaaatgct gtacaaatgc ttaagacaat agatgcaatg     2640



gatacatggg aagatctgac tgaacttggg tatcatttgg ctgacttgcc agtagaacca     2700



catcttggta aaatggtctt gtgtgctgtt gttttaaagt gtctggaccc catccttaca     2760



attgcttgca cactagctta tcgagatcct tttgtactac ctactcaggc ctctcaaaaa     2820



cgtgcagcta tgctttgtag gaaacgtttt actgcaggag ctttcagtga ccatatggca     2880



cttctcagag cattccaggc ctggcaaaaa gcacgaagtg atgggtggga gcgagccttt     2940



tgtgaaaaga attttctttc acaggctact atggaaataa tcataggcat gagaacacag     3000



ttgcttggtc aacttagagc atcaggtttt gttagagcac gaggtggtgg tgacattcgg     3060



gacgttaaca caaactctga gaattgggct gtcgttaaag ctgcattggt ggcaggcatg     3120



tatcctaatt tagtccacgt ggacagagag aatctagtgt tgacagggcc aaaggagaaa     3180



aaagtacgat ttcatcctgc ttcagttctc agtcagcctc aatataaaaa gattcctcca     3240



gccaatggtc aagctgcagc aattaaggca ctgcccacag attggcttat ttatgatgaa     3300



atgaccagag cccatagaat agctaatatt agatgttgtt cagcagtgac gcctgtcact     3360



atattggtat tctgtggacc agctagattg gcaagtaatg ctcttcagga accttcatcc     3420



tttagagtgg atggcattcc caatgacagt agtgatagtg aaatggagga caaaactaca     3480



gctaatttgg cagccttgaa acttgatgag tggctccatt tcacactgga gccagaggca     3540



gctagtttat tgctgcagct cagacagaag tggcatagct tatttttacg ccgaatgaga     3600



gctccatcta aaccttggtc tcaagttgat gaagctacca taagagcaat tatagctgtt     3660



ttaagcactg aagaacagtc tgcaggttta caacaaccat ctgggattgg ccaaaggcca     3720



aggcctatgt cttcagaaga gcttcctttg gcctcatctt ggaggtcaaa taatagtagg     3780



aaaagttcag cagatactga attttctgat gagtgtacta ctgcagaaag agtactgatg     3840



aaatctccat ctccagcatt acacccacct cagaagtaca aagatagagg aattttacat     3900



cctaaacgag gtactgagga ccgatcagat cagtcttctc tgaaatctac agacagcagt     3960



agttacccaa gtccttgtgc tagtccttct cctccatcct caggaaaggg ctcaaaatct     4020



ccttcgccaa gaccaaacat gcctgttcga tacttcataa tgaagagtag caatttgaga     4080



aaccttgaaa tttctcaaca gaagggtatc tggtctacaa ctcctagtaa tgaacggaag     4140



ctaaatcgag ccttttggga aagcagcata gtttacttgg tattttctgt tcaaggatct     4200



ggacatttcc agggattttc taggatgtct tctgagattg gaagggaaaa gagtcaggac     4260



tggggctctg ctggactagg aggagtattt aaggtggagt ggatacgaaa agaaagcctt     4320



ccctttcaat ttgcacacca tttactcaat ccatggaatg acaacaagaa agtgcagata     4380



agcagggatg ggcaggaact agaacctctg gttggtgaac agttgctcca gttatgggaa     4440



cgtcttccct tgggagaaaa aaacacaact gattgacact cagaactctt agctgtggaa     4500



gaacatcatg cctatttata accactgaat gcactgactt tcaaaaactg aggtggggtg     4560



tgtgttacga atgggctttt taacactttt agagtgttgc tttagaacta ccatcttcat     4620



atacaggaga aaggaagcat ttaaattttt atagtgatta tagagaatga ttatatgatg     4680



tttgtaatga ataaaatagt agtttcatta tttggcacaa tagcagttta ttttaaacaa     4740



acaatttgaa gttaaacatt tcatttttaa aaacactgaa ttacagttct tattgatgac     4800



tttttaatgc agagtaagtt gtttaagaaa ggcctgaata tatcagaaca tctgagcacc     4860



attttagaag agtcaactct taagattatc attagaaaac aaatacgtca acacctatga     4920



aaagaagcgg ggaaaacaac aacaaggaca acaacaaaaa accagtgaaa ttctacaagt     4980



gtccctttta aaaatagtgt gtgctaacta agggctattc attctgccat ttttaacttg     5040



agacacattt aagaataaag ttggatgttc tttttctgtg attatgaaat gcaataaaat     5100



ctgaataaag ggcaaagttt cttcctgatc agattagatt aagtgcttag ttttattcct     5160



aattctgccc cttttaacct gatgtgtacc ttactctttc ctccctctct tcctcccttc     5220



ctcctctccc cactcctttc ctgcatttct ccctccctcc ttccctcgtc acatctctta     5280



tatgagcaca gtaattatga cctttttgtt ttggctacaa cttgattgaa acaagttcaa     5340



aatttaaaca agttcataca agtttttaaa aattctcaac tggtagcttg cttgctgtgc     5400



gtcttccaaa ctaaagcctg caagcgccac aattctaagt gccgccttcc attttttttc     5460



agtatgtttt cactggctta tgttttcaga tatgattttc ctttttcgca tatatggttt     5520



aataaatggg ggataatttt ttttttgtaa atccgtgctt gtgccaagtc tcatatttct     5580



ttgccatctc agaattatct ttttaccacc actgtttata aaatttcctt agagactttt     5640



tgaagggaaa atagagcaac agggaaaaat gaaagaaatg tcttggttac tgagctctaa     5700



atagacaggt ttgatggcac ttctcatgat acattttagt tattcttata aaagcaaaca     5760



ggcaaacatg agtgtaaatt aaagacaaaa agaaaactct ggttttatat ttgagaacac     5820



gtgaaaaatc atgggtcaac ataaaatctt gagaaccttc tactttctct gggaaagcat     5880



tatatagtgg tgcattagtt tagaaagtca gctatgattt tgcctatagt tctagttatt     5940



agctttgggg ttttcttgta ctttaagaca tacctgtaaa ttgaacctat ttgaattata     6000



ttccactgta tgtgtattat ggctcttttc ctattagagc aacttgtgtt tccctgataa     6060



tgtgtacatt ttttaggcat gtacttaata gttcacaatg ttctaaattt ggaaggactt     6120



aaaaaaaaaa cttgtttaaa tttccatctg ttttgtaata tctagctcta tatgtaaatg     6180



atgggtttgt tggtatttaa aatgaataca acttgaatgt aattaaagtg ctgttttttg     6240



gaagcgataa actttaaata tacttattaa aatgaaattc tattaaaaaa aaaaaaaaaa     6300



a                                                                     6301





<210>  359

<211>  1430

<212>  PRT

<213>  Homo sapiens



<400>  359



Met Ser Arg Pro Ser Ser Val Ser Pro Arg Gln Pro Ala Pro Gly Gly 

1               5                   10                  15      





Gly Gly Gly Gly Gly Pro Ser Pro Cys Gly Pro Gly Gly Gly Gly Arg 

            20                  25                  30          





Ala Lys Gly Leu Lys Asp Ile Arg Ile Asp Glu Glu Val Lys Ile Ala 

        35                  40                  45              





Val Asn Ile Ala Leu Glu Arg Phe Arg Tyr Gly Asp Gln Arg Glu Met 

    50                  55                  60                  





Glu Phe Pro Ser Ser Leu Thr Ser Thr Glu Arg Ala Phe Ile His Arg 

65                  70                  75                  80  





Leu Ser Gln Ser Leu Gly Leu Val Ser Lys Ser Lys Gly Lys Gly Ala 

                85                  90                  95      





Asn Arg Tyr Leu Thr Val Lys Lys Lys Asp Gly Ser Glu Thr Ala His 

            100                 105                 110         





Ala Met Met Thr Cys Asn Leu Thr His Asn Thr Lys His Ala Val Arg 

        115                 120                 125             





Ser Leu Ile Gln Arg Phe Pro Val Thr Asn Lys Glu Arg Thr Glu Leu 

    130                 135                 140                 





Leu Pro Lys Thr Glu Arg Gly Asn Val Phe Ala Val Glu Ala Glu Asn 

145                 150                 155                 160 





Arg Glu Met Ser Lys Thr Ser Gly Arg Leu Asn Asn Gly Ile Pro Gln 

                165                 170                 175     





Ile Pro Val Lys Arg Gly Glu Ser Glu Phe Asp Ser Phe Arg Gln Ser 

            180                 185                 190         





Leu Pro Val Phe Glu Lys Gln Glu Glu Ile Val Lys Ile Ile Lys Glu 

        195                 200                 205             





Asn Lys Val Val Leu Ile Val Gly Glu Thr Gly Ser Gly Lys Thr Thr 

    210                 215                 220                 





Gln Ile Pro Gln Phe Leu Leu Asp Asp Cys Phe Lys Asn Gly Ile Pro 

225                 230                 235                 240 





Cys Arg Ile Phe Cys Thr Gln Pro Arg Arg Leu Ala Ala Ile Ala Val 

                245                 250                 255     





Ala Glu Arg Val Ala Ala Glu Arg Arg Glu Arg Ile Gly Gln Thr Ile 

            260                 265                 270         





Gly Tyr Gln Ile Arg Leu Glu Ser Arg Val Ser Pro Lys Thr Leu Leu 

        275                 280                 285             





Thr Phe Cys Thr Asn Gly Val Leu Leu Arg Thr Leu Met Ala Gly Asp 

    290                 295                 300                 





Ser Thr Leu Ser Thr Val Thr His Val Ile Val Asp Glu Val His Glu 

305                 310                 315                 320 





Arg Asp Arg Phe Ser Asp Phe Leu Leu Thr Lys Leu Arg Asp Leu Leu 

                325                 330                 335     





Gln Lys His Pro Thr Leu Lys Leu Ile Leu Ser Ser Ala Ala Leu Asp 

            340                 345                 350         





Val Asn Leu Phe Ile Arg Tyr Phe Gly Ser Cys Pro Val Ile Tyr Ile 

        355                 360                 365             





Gln Gly Arg Pro Phe Glu Val Lys Glu Met Phe Leu Glu Asp Ile Leu 

    370                 375                 380                 





Arg Thr Thr Gly Tyr Thr Asn Lys Glu Met Leu Lys Tyr Lys Lys Glu 

385                 390                 395                 400 





Lys Gln Gln Glu Glu Lys Gln Gln Thr Thr Leu Thr Glu Trp Tyr Ser 

                405                 410                 415     





Ala Gln Glu Asn Ser Phe Lys Pro Glu Ser Gln Arg Gln Arg Thr Val 

            420                 425                 430         





Leu Asn Val Thr Asp Glu Tyr Asp Leu Leu Asp Asp Gly Gly Asp Ala 

        435                 440                 445             





Val Phe Ser Gln Leu Thr Glu Lys Asp Val Asn Cys Leu Glu Pro Trp 

    450                 455                 460                 





Leu Ile Lys Glu Met Asp Ala Cys Leu Ser Asp Ile Trp Leu His Lys 

465                 470                 475                 480 





Asp Ile Asp Ala Phe Ala Gln Val Phe His Leu Ile Leu Thr Glu Asn 

                485                 490                 495     





Val Ser Val Asp Tyr Arg His Ser Glu Thr Ser Ala Thr Ala Leu Met 

            500                 505                 510         





Val Ala Ala Gly Arg Gly Phe Ala Ser Gln Val Glu Gln Leu Ile Ser 

        515                 520                 525             





Met Gly Ala Asn Val His Ser Lys Ala Ser Asn Gly Trp Met Ala Leu 

    530                 535                 540                 





Asp Trp Ala Lys His Phe Gly Gln Thr Glu Ile Val Asp Leu Leu Glu 

545                 550                 555                 560 





Ser Tyr Ser Ala Ser Leu Glu Phe Gly Asn Leu Asp Glu Ser Ser Leu 

                565                 570                 575     





Val Gln Thr Asn Gly Ser Asp Leu Ser Ala Glu Asp Arg Glu Leu Leu 

            580                 585                 590         





Lys Ala Tyr His His Ser Phe Asp Asp Glu Lys Val Asp Leu Asp Leu 

        595                 600                 605             





Ile Met His Leu Leu Tyr Asn Ile Cys His Ser Cys Asp Ala Gly Ala 

    610                 615                 620                 





Val Leu Ile Phe Leu Pro Gly Tyr Asp Glu Ile Val Gly Leu Arg Asp 

625                 630                 635                 640 





Arg Ile Leu Phe Asp Asp Lys Arg Phe Ala Asp Asn Thr His Arg Tyr 

                645                 650                 655     





Gln Val Phe Met Leu His Ser Asn Met Gln Thr Ser Asp Gln Lys Lys 

            660                 665                 670         





Val Leu Lys Asn Pro Pro Ala Gly Val Arg Lys Ile Ile Leu Ser Thr 

        675                 680                 685             





Asn Ile Ala Glu Thr Ser Ile Thr Val Asn Asp Val Val Phe Val Ile 

    690                 695                 700                 





Asp Ser Gly Lys Val Lys Glu Lys Ser Phe Asp Ala Leu Asn Phe Val 

705                 710                 715                 720 





Thr Met Leu Lys Met Val Trp Ile Ser Lys Ala Ser Ala Ile Gln Arg 

                725                 730                 735     





Lys Gly Arg Ala Gly Arg Cys Arg Pro Gly Ile Cys Phe Arg Leu Phe 

            740                 745                 750         





Ser Arg Leu Arg Phe Gln Asn Met Leu Glu Phe Gln Thr Pro Glu Leu 

        755                 760                 765             





Leu Arg Met Pro Leu Gln Glu Leu Cys Leu His Thr Lys Leu Leu Ala 

    770                 775                 780                 





Pro Val Asn Cys Pro Ile Ala Asp Phe Leu Met Lys Ala Pro Glu Pro 

785                 790                 795                 800 





Pro Pro Ala Leu Ile Val Arg Asn Ala Val Gln Met Leu Lys Thr Ile 

                805                 810                 815     





Asp Ala Met Asp Thr Trp Glu Asp Leu Thr Glu Leu Gly Tyr His Leu 

            820                 825                 830         





Ala Asp Leu Pro Val Glu Pro His Leu Gly Lys Met Val Leu Cys Ala 

        835                 840                 845             





Val Val Leu Lys Cys Leu Asp Pro Ile Leu Thr Ile Ala Cys Thr Leu 

    850                 855                 860                 





Ala Tyr Arg Asp Pro Phe Val Leu Pro Thr Gln Ala Ser Gln Lys Arg 

865                 870                 875                 880 





Ala Ala Met Leu Cys Arg Lys Arg Phe Thr Ala Gly Ala Phe Ser Asp 

                885                 890                 895     





His Met Ala Leu Leu Arg Ala Phe Gln Ala Trp Gln Lys Ala Arg Ser 

            900                 905                 910         





Asp Gly Trp Glu Arg Ala Phe Cys Glu Lys Asn Phe Leu Ser Gln Ala 

        915                 920                 925             





Thr Met Glu Ile Ile Ile Gly Met Arg Thr Gln Leu Leu Gly Gln Leu 

    930                 935                 940                 





Arg Ala Ser Gly Phe Val Arg Ala Arg Gly Gly Gly Asp Ile Arg Asp 

945                 950                 955                 960 





Val Asn Thr Asn Ser Glu Asn Trp Ala Val Val Lys Ala Ala Leu Val 

                965                 970                 975     





Ala Gly Met Tyr Pro Asn Leu Val His Val Asp Arg Glu Asn Leu Val 

            980                 985                 990         





Leu Thr Gly Pro Lys Glu Lys Lys  Val Arg Phe His Pro  Ala Ser Val 

        995                 1000                 1005             





Leu Ser  Gln Pro Gln Tyr Lys  Lys Ile Pro Pro Ala  Asn Gly Gln 

    1010                 1015                 1020             





Ala Ala  Ala Ile Lys Ala Leu  Pro Thr Asp Trp Leu  Ile Tyr Asp 

    1025                 1030                 1035             





Glu Met  Thr Arg Ala His Arg  Ile Ala Asn Ile Arg  Cys Cys Ser 

    1040                 1045                 1050             





Ala Val  Thr Pro Val Thr Ile  Leu Val Phe Cys Gly  Pro Ala Arg 

    1055                 1060                 1065             





Leu Ala  Ser Asn Ala Leu Gln  Glu Pro Ser Ser Phe  Arg Val Asp 

    1070                 1075                 1080             





Gly Ile  Pro Asn Asp Ser Ser  Asp Ser Glu Met Glu  Asp Lys Thr 

    1085                 1090                 1095             





Thr Ala  Asn Leu Ala Ala Leu  Lys Leu Asp Glu Trp  Leu His Phe 

    1100                 1105                 1110             





Thr Leu  Glu Pro Glu Ala Ala  Ser Leu Leu Leu Gln  Leu Arg Gln 

    1115                 1120                 1125             





Lys Trp  His Ser Leu Phe Leu  Arg Arg Met Arg Ala  Pro Ser Lys 

    1130                 1135                 1140             





Pro Trp  Ser Gln Val Asp Glu  Ala Thr Ile Arg Ala  Ile Ile Ala 

    1145                 1150                 1155             





Val Leu  Ser Thr Glu Glu Gln  Ser Ala Gly Leu Gln  Gln Pro Ser 

    1160                 1165                 1170             





Gly Ile  Gly Gln Arg Pro Arg  Pro Met Ser Ser Glu  Glu Leu Pro 

    1175                 1180                 1185             





Leu Ala  Ser Ser Trp Arg Ser  Asn Asn Ser Arg Lys  Ser Ser Ala 

    1190                 1195                 1200             





Asp Thr  Glu Phe Ser Asp Glu  Cys Thr Thr Ala Glu  Arg Val Leu 

    1205                 1210                 1215             





Met Lys  Ser Pro Ser Pro Ala  Leu His Pro Pro Gln  Lys Tyr Lys 

    1220                 1225                 1230             





Asp Arg  Gly Ile Leu His Pro  Lys Arg Gly Thr Glu  Asp Arg Ser 

    1235                 1240                 1245             





Asp Gln  Ser Ser Leu Lys Ser  Thr Asp Ser Ser Ser  Tyr Pro Ser 

    1250                 1255                 1260             





Pro Cys  Ala Ser Pro Ser Pro  Pro Ser Ser Gly Lys  Gly Ser Lys 

    1265                 1270                 1275             





Ser Pro  Ser Pro Arg Pro Asn  Met Pro Val Arg Tyr  Phe Ile Met 

    1280                 1285                 1290             





Lys Ser  Ser Asn Leu Arg Asn  Leu Glu Ile Ser Gln  Gln Lys Gly 

    1295                 1300                 1305             





Ile Trp  Ser Thr Thr Pro Ser  Asn Glu Arg Lys Leu  Asn Arg Ala 

    1310                 1315                 1320             





Phe Trp  Glu Ser Ser Ile Val  Tyr Leu Val Phe Ser  Val Gln Gly 

    1325                 1330                 1335             





Ser Gly  His Phe Gln Gly Phe  Ser Arg Met Ser Ser  Glu Ile Gly 

    1340                 1345                 1350             





Arg Glu  Lys Ser Gln Asp Trp  Gly Ser Ala Gly Leu  Gly Gly Val 

    1355                 1360                 1365             





Phe Lys  Val Glu Trp Ile Arg  Lys Glu Ser Leu Pro  Phe Gln Phe 

    1370                 1375                 1380             





Ala His  His Leu Leu Asn Pro  Trp Asn Asp Asn Lys  Lys Val Gln 

    1385                 1390                 1395             





Ile Ser  Arg Asp Gly Gln Glu  Leu Glu Pro Leu Val  Gly Glu Gln 

    1400                 1405                 1410             





Leu Leu  Gln Leu Trp Glu Arg  Leu Pro Leu Gly Glu  Lys Asn Thr 

    1415                 1420                 1425             





Thr Asp  

    1430 





<210>  360

<211>  3105

<212>  DNA

<213>  Homo sapiens



<400>  360

cgcggcggca gcagcagcag cagcagcgag aggcagaggc ggcggcggcg gggaggacag       60



cacggccgag gctgcccagc ggcgcctcct ccacaccccc cgccgcagca gcaccggcga      120



cagatttttt aaaaaatgga tttggccaac catggactta ttctactgca acagttaaac      180



gctcagcgag agtttggttt cctgtgtgac tgcacggttg caatcggcga tgtatacttc      240



aaggcacaca aatcagttct tgcttcattc tccaattact ttaagatgtt gtttgtccat      300



cagaccagtg agtgtgtccg cttgaaacca actgacatac agcccgacat cttcagctat      360



ctcttacact tgatgtacac tgggaagatg gcgcctcagc tcatcgaccc ggttcgatta      420



gaacagggca tcaagtttct gcacgcctac ccgctcattc aggaagccag cctcgccagc      480



cagggagcct tttctcaccc tgaccaagtt ttcccactgg cttcttcatt gtatggcatt      540



cagattgcag atcatcagtt gagacaagcc accaagattg cttcagcacc tgaaaaactc      600



gggcgagatc cacggccaca gacctccagg ataagccagg agcaggtccc tgaggcctca      660



cagctctccc agctgacttc aaatctggcc caggtgaatc ggacaaatat gactccctca      720



gaccccctgc agacctcgct gtctccagaa cttgtttcca ctcctgttcc tccccctcct      780



cccggggagg agaccaatct ggaagcatct tcctccgatg agcagcctgc gtccctcaca      840



atagcccacg tcaagccaag catcatgaag aggaatggga gctttccaaa gtactatgcc      900



tgccacctgt gtggacggcg cttcactctc cggagcagct tacgtgaaca cctccagatc      960



cacacaggag tacctttcac atctagccaa cagggagaaa gtcgcgtccc cctgactctc     1020



tgtagcaatg cagctgacct cgggaaagat gccatggaag tgcctgaagc cgggatgata     1080



agtgacagtg agctgcagca catctctgat tctcccatca tcgatgggca gcagcagtcg     1140



gaaaccccac ccccctcaga cattgctgac attgacaacc tggagcaggc cgaccaggag     1200



agggaggtga agaggcggaa gtacgagtgc acaatatgtg gacgcaaatt tatccagaaa     1260



agccactgga gggaacacat gtacatacac accgggaagc ctttcaagtg cagcacttgt     1320



gacaaaagct tttgcagggc caaccaggct gcccgccacg tgtgcctcaa ccagagcatc     1380



gacacttaca ccatggtgga caaacagact ctggaactct gcacatttga ggaagggagt     1440



cagatggaca acatgctggt gcaaacaaac aaaccctaca aatgcaactt gtgtgacaaa     1500



acattctcca ctcccaatga ggttgttaaa cattcatgcc aaaaccagaa ctcggatgtt     1560



tttgccctag acgaagggcg atccattctc ctgggcagtg gggactcgga agtaacggag     1620



cctgaccacc cagtgttagc ttccatcaaa aaggaacaag aaaccgtctt actagactga     1680



atgtcactta tctttttaaa aaactctcat ttttacaaag actatcttcc ctcccttccc     1740



tgaattcaga actgtagttc tccatggcat gatacaaaca ggtccttgtt ctcttctcct     1800



cttccccttt tccacatccc agccccacct ctgtaaaggc tttgtgcatt ataaacctgg     1860



aatgtatcga ctttctttca ggggatattg gaaagataat ggtcattata cttataaact     1920



caaattttga gaggttttag attattcaga agcatacttg gaactaatga agggtatata     1980



ataaaacaac tggaatccaa tttggtaagc taaaattatg actttccctg ggtaaaaagt     2040



cttctcagaa aaacaatgtc agaaaataac agcgtgctgc ttagaaatac ggctgggctc     2100



tgtactatgc aaaatctaga aagtgtgggg aaactttaaa cccaagaaaa cgttcttagt     2160



attcatcctc caggtgtctt acttcagaat gcatcctttg agattatgtc cacttaagag     2220



aaatcatcag ttaagaaatc tactttaaca aaacaaaaag gagaaaaagt aataatgtga     2280



tggcaatctt aatttttggg tacaacatga caagctgtga gtttgtgtgt ttgtaagaga     2340



aaaatgtgtg ggtacttgct aataaacagg tgaattaatg cacatcctta tctcattgct     2400



ggcttctttc caagttgagc aacaacaaaa tgctgtattt gagtttctga caaatttgtt     2460



ttaaaaatca aatttgaatg tactattcta taaattgcct ttctgaatag aacatgacat     2520



gccattttct agcagctgcc agtgataatt tgttttacac taacttttaa atcagtgtgt     2580



gtactgcagg gaaaaggata taggaatact catcttacag gggaatttgt gaccagaaga     2640



tgtagtaact tcaatgactg aaagtcaatg ctgatagttt actggcaaca ttaattgaag     2700



catcaaaaat aaatggcaaa gagaaatcag gacaaaaaat ctaattgctg tttgggaaaa     2760



aacttgattt tgatgtttat tctccaggtt tttggttgtt tttttttctt tcttctttct     2820



taatgcctga aattttctcc attggcccga aagcagtaaa aattgttcat taatcttccg     2880



ttaggccaat aaaagaaggg cctcacaaga caaaacagga gccagaagta aggactgaag     2940



gagaagggga gaatagctaa tagctatagt atatgtatat gttaaaaact gaatatccca     3000



tcatcctatt tcatgtatag ttgagttctc aaatttgtaa gtttttatac atcctttcat     3060



tgaataaacg tttaattaaa tgagtaaaaa aaaaaaaaaa aaaaa                     3105





<210>  361

<211>  514

<212>  PRT

<213>  Homo sapiens



<400>  361



Met Asp Leu Ala Asn His Gly Leu Ile Leu Leu Gln Gln Leu Asn Ala 

1               5                   10                  15      





Gln Arg Glu Phe Gly Phe Leu Cys Asp Cys Thr Val Ala Ile Gly Asp 

            20                  25                  30          





Val Tyr Phe Lys Ala His Lys Ser Val Leu Ala Ser Phe Ser Asn Tyr 

        35                  40                  45              





Phe Lys Met Leu Phe Val His Gln Thr Ser Glu Cys Val Arg Leu Lys 

    50                  55                  60                  





Pro Thr Asp Ile Gln Pro Asp Ile Phe Ser Tyr Leu Leu His Leu Met 

65                  70                  75                  80  





Tyr Thr Gly Lys Met Ala Pro Gln Leu Ile Asp Pro Val Arg Leu Glu 

                85                  90                  95      





Gln Gly Ile Lys Phe Leu His Ala Tyr Pro Leu Ile Gln Glu Ala Ser 

            100                 105                 110         





Leu Ala Ser Gln Gly Ala Phe Ser His Pro Asp Gln Val Phe Pro Leu 

        115                 120                 125             





Ala Ser Ser Leu Tyr Gly Ile Gln Ile Ala Asp His Gln Leu Arg Gln 

    130                 135                 140                 





Ala Thr Lys Ile Ala Ser Ala Pro Glu Lys Leu Gly Arg Asp Pro Arg 

145                 150                 155                 160 





Pro Gln Thr Ser Arg Ile Ser Gln Glu Gln Val Pro Glu Ala Ser Gln 

                165                 170                 175     





Leu Ser Gln Leu Thr Ser Asn Leu Ala Gln Val Asn Arg Thr Asn Met 

            180                 185                 190         





Thr Pro Ser Asp Pro Leu Gln Thr Ser Leu Ser Pro Glu Leu Val Ser 

        195                 200                 205             





Thr Pro Val Pro Pro Pro Pro Pro Gly Glu Glu Thr Asn Leu Glu Ala 

    210                 215                 220                 





Ser Ser Ser Asp Glu Gln Pro Ala Ser Leu Thr Ile Ala His Val Lys 

225                 230                 235                 240 





Pro Ser Ile Met Lys Arg Asn Gly Ser Phe Pro Lys Tyr Tyr Ala Cys 

                245                 250                 255     





His Leu Cys Gly Arg Arg Phe Thr Leu Arg Ser Ser Leu Arg Glu His 

            260                 265                 270         





Leu Gln Ile His Thr Gly Val Pro Phe Thr Ser Ser Gln Gln Gly Glu 

        275                 280                 285             





Ser Arg Val Pro Leu Thr Leu Cys Ser Asn Ala Ala Asp Leu Gly Lys 

    290                 295                 300                 





Asp Ala Met Glu Val Pro Glu Ala Gly Met Ile Ser Asp Ser Glu Leu 

305                 310                 315                 320 





Gln His Ile Ser Asp Ser Pro Ile Ile Asp Gly Gln Gln Gln Ser Glu 

                325                 330                 335     





Thr Pro Pro Pro Ser Asp Ile Ala Asp Ile Asp Asn Leu Glu Gln Ala 

            340                 345                 350         





Asp Gln Glu Arg Glu Val Lys Arg Arg Lys Tyr Glu Cys Thr Ile Cys 

        355                 360                 365             





Gly Arg Lys Phe Ile Gln Lys Ser His Trp Arg Glu His Met Tyr Ile 

    370                 375                 380                 





His Thr Gly Lys Pro Phe Lys Cys Ser Thr Cys Asp Lys Ser Phe Cys 

385                 390                 395                 400 





Arg Ala Asn Gln Ala Ala Arg His Val Cys Leu Asn Gln Ser Ile Asp 

                405                 410                 415     





Thr Tyr Thr Met Val Asp Lys Gln Thr Leu Glu Leu Cys Thr Phe Glu 

            420                 425                 430         





Glu Gly Ser Gln Met Asp Asn Met Leu Val Gln Thr Asn Lys Pro Tyr 

        435                 440                 445             





Lys Cys Asn Leu Cys Asp Lys Thr Phe Ser Thr Pro Asn Glu Val Val 

    450                 455                 460                 





Lys His Ser Cys Gln Asn Gln Asn Ser Asp Val Phe Ala Leu Asp Glu 

465                 470                 475                 480 





Gly Arg Ser Ile Leu Leu Gly Ser Gly Asp Ser Glu Val Thr Glu Pro 

                485                 490                 495     





Asp His Pro Val Leu Ala Ser Ile Lys Lys Glu Gln Glu Thr Val Leu 

            500                 505                 510         





Leu Asp 

        





<210>  362

<211>  3332

<212>  DNA

<213>  Homo sapiens



<400>  362

ctccctccag gaaggccgtt gtcttccctg ggacgacttg ccagctctga ggcatgacag       60



tacgggcccc cagaagggtg accaggaggc cctcctcgtc ccagctgccg gcgtcgccgc      120



ccactgcagg gcccgggctg tgactcgtgg ggacggttcc ctgcgccccg gcgggggagg      180



tgggcgggga ggggcggcgg ggcgccgggg cggggctcgg gacggccggg ctgggagctg      240



gagcccacag cgggaagcgg ccgccgcccg ggcctcgcag ggctaggcga ggcgaggggg      300



ggcggggccg ggcgctacgg gaaggggagg ccgcgcggac cgggagccgc accgcgccag      360



ccgggctgca gcggccgcgc accaaggctg cgatggggct ggagacggag aaggcggacg      420



tacagctctt catggacgac gactcctaca gccaccacag cggcctcgag tacgccgacc      480



ccgagaagtt cgcggactcg gaccaggacc gggatcccca ccggctcaac tcgcatctca      540



agctgggctt cgaggatgtg atcgcagagc cggtgactac gcactccttt gacaaagtgt      600



ggatctgcag ccatgccctc tttgaaatca gcaaatacgt aatgtacaag ttcctgacgg      660



tgttcctggc cattcccctg gccttcattg cgggaattct ctttgccacc ctcagctgtc      720



tgcacatctg gattttaatg ccttttgtaa agacctgcct aatggttctg ccttcagtgc      780



agacaatatg gaagagtgtg acagatgtta tcattgctcc attgtgtacg agcgtaggac      840



gatgcttctc ttctgtcagc ctgcaactga gccaggattg aatacttgga ccccaggtct      900



ggagattggg atactgtaat acttctttgt tattataaca taaaagcacc actgttctgt      960



tcatttccta gctgttctaa ttaagaaaac tattaagatg agcaaccaca tttagaaatg     1020



tttattgaca ggtcttttca aataatgctt ttctaattaa tagccaaaga tttcatatct     1080



aactttgtaa ccagaattat acagtaagtt gacaccactt agatttaaag gcagacagtt     1140



ttgctttagt acaatagtat acattttata atgatgaact tataatgatt aagggacatt     1200



tctataaaaa tactacaata gttttatgca caacttccca ttaaaaatga gatttcttat     1260



ttgtttgtct gtttttactc tgggagtaat actttttaaa ttacctttac atatatagtc     1320



actggcatac tgagaatata caatgatcct ggaaattgca gtaacaaaag cacacaacga     1380



ttatagtaac tataagatac aataaaacaa ataaatatga aagtagattc atgaaaatgt     1440



attcctttaa aatattgttt tcctacaggc ctatttaaca agatgtttca ttttactgta     1500



tattttgtag ttaatataaa tgttgctcta atcagattgc ttaaaagcat ttttattata     1560



tttatgttgt tgaactaata tatgaaataa gtaaatgtag ctcccacaag gtaaacttca     1620



ttggtaagat tgcactgttc tgattatgta agcatttgta catcttcttt ggaaataaaa     1680



gataaaagag cgatacacaa agctttcttt tctaactttt ccaagcaaaa tctaaaatgt     1740



tttatgacat ttttctggct gtgatcttaa aataattcat atctaaatag tattttgtct     1800



aggagatgct ttctctctag tagttagaaa ttaaatctgt gtcagcattc ctattaatgt     1860



ctcactttac tttcaagtaa tattggtgct atttaacatt ttacagtaaa tgttacttct     1920



gatactttag tacaatttca actacagtga ttcatgtaga gagacagggg agttgtcaac     1980



ttgggctact gaactacatg cataaactaa aaactaacag ctacaaactt ttaagatttc     2040



tctaatattg gtatgtaaca caggataaag ttattcttgt cattttgaac tgtagagtcc     2100



tatttcagtg tgatgaatca ctgttgcttt gaaaaatctc attatttctg ggccgggcat     2160



ggtggctcac ccctgtaatc ccagcacttt gggaggccaa ggcgggtgga tcatgaggtc     2220



aggagatcaa gaccatcctg gccaacatgg tgataccccg tctctactaa aaatacaaaa     2280



aaattagttg ggcatggtgg catgcacctg tagtcccagc tacctgggag gctgaggcag     2340



gagaattgct tgaacctggg aggcagaggt tgcagtgagc caaaatcatg ccactgcact     2400



cccgcctggc aacagagcaa gagtctgtct caaaaaaaaa aagaaaaaaa gaaaaaaaga     2460



aaaaagaaaa atctcattat ttcaaaatga tagacatata ccaaaaacaa gtctataatg     2520



tgagtagtta ctaaaattta cacatcttaa aagtgtgtaa atgcttaaat ttcagaatta     2580



ccatcagaac ctcaattgac attcctttga atacgctaat aagtgacaaa taagattaat     2640



aagatttttc aaaatcgcca ggactggtga atataaatga tgattgaact ggaataatat     2700



tggggaccaa atcaaatgaa tgattaaatt atgaagctca tatccttttg aaggtagttg     2760



caaagagaca tttcaaaact gccctaggcc attgcagcat ccttagatgg gacgcataat     2820



cattacctta aagcatcacc actcattttg accatataga ttttattatg ttagtttaaa     2880



aggtcaatca gcctcatgac tttatagtta tgtcttgtat ttaaaaacat tttttataca     2940



tttggttatg ttgataaacc aaaaacattt gattaataaa atatctattt gaataaatta     3000



tgagctatcc tttcaaacag ctattggcaa gttttaaacc caaaatatat acacatagtt     3060



ctgtaataaa actgtttgac ttctcaagta acatgacttc cttatttctg aacagtactg     3120



gttactttca aaatgaattt ttattgagat tttccattaa ctattttttt caaagactca     3180



aattttgtac caagtaaatc caggctttat gtacaaacat gttgtttgtt ttatttgggg     3240



ctgggggagg tatatgatga gcagacttct cggaattcat aataaatttt ctaaaagcct     3300



aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                   3332





<210>  363

<211>  162

<212>  PRT

<213>  Homo sapiens



<400>  363



Met Gly Leu Glu Thr Glu Lys Ala Asp Val Gln Leu Phe Met Asp Asp 

1               5                   10                  15      





Asp Ser Tyr Ser His His Ser Gly Leu Glu Tyr Ala Asp Pro Glu Lys 

            20                  25                  30          





Phe Ala Asp Ser Asp Gln Asp Arg Asp Pro His Arg Leu Asn Ser His 

        35                  40                  45              





Leu Lys Leu Gly Phe Glu Asp Val Ile Ala Glu Pro Val Thr Thr His 

    50                  55                  60                  





Ser Phe Asp Lys Val Trp Ile Cys Ser His Ala Leu Phe Glu Ile Ser 

65                  70                  75                  80  





Lys Tyr Val Met Tyr Lys Phe Leu Thr Val Phe Leu Ala Ile Pro Leu 

                85                  90                  95      





Ala Phe Ile Ala Gly Ile Leu Phe Ala Thr Leu Ser Cys Leu His Ile 

            100                 105                 110         





Trp Ile Leu Met Pro Phe Val Lys Thr Cys Leu Met Val Leu Pro Ser 

        115                 120                 125             





Val Gln Thr Ile Trp Lys Ser Val Thr Asp Val Ile Ile Ala Pro Leu 

    130                 135                 140                 





Cys Thr Ser Val Gly Arg Cys Phe Ser Ser Val Ser Leu Gln Leu Ser 

145                 150                 155                 160 





Gln Asp 

        





<210>  364

<211>  3144

<212>  DNA

<213>  Homo sapiens



<400>  364

ctccctccag gaaggccgtt gtcttccctg ggacgacttg ccagctctga ggcatgacag       60



tacgggcccc cagaagggtg accaggaggc cctcctcgtc ccagctgccg gcgtcgccgc      120



ccactgcagg gcccgggctg tgactcgtgg ggacggttcc ctgcgccccg gcgggggagg      180



tgggcgggga ggggcggcgg ggcgccgggg cggggctcgg gacggccggg ctgggagctg      240



gagcccacag cgggaagcgg ccgccgcccg ggcctcgcag ggctaggcga ggcgaggggg      300



ggcggggccg ggcgctacgg gaaggggagg ccgcgcggac cgggagccgc accgcgccag      360



ccgggctgca gcggccgcgc accaaggctg cgatggggct ggagacggag aaggcggacg      420



tacagctctt catggacgac gactcctaca gccaccacag cggcctcgag tacgccgacc      480



ccgagaagtt cgcggactcg gaccaggacc gggatcccca ccggctcaac tcgcatctca      540



aggattttaa tgccttttgt aaagacctgc ctaatggttc tgccttcagt gcagacaata      600



tggaagagtg tgacagatgt tatcattgct ccattgtgta cgagcgtagg acgatgcttc      660



tcttctgtca gcctgcaact gagccaggat tgaatacttg gaccccaggt ctggagattg      720



ggatactgta atacttcttt gttattataa cataaaagca ccactgttct gttcatttcc      780



tagctgttct aattaagaaa actattaaga tgagcaacca catttagaaa tgtttattga      840



caggtctttt caaataatgc ttttctaatt aatagccaaa gatttcatat ctaactttgt      900



aaccagaatt atacagtaag ttgacaccac ttagatttaa aggcagacag ttttgcttta      960



gtacaatagt atacatttta taatgatgaa cttataatga ttaagggaca tttctataaa     1020



aatactacaa tagttttatg cacaacttcc cattaaaaat gagatttctt atttgtttgt     1080



ctgtttttac tctgggagta atacttttta aattaccttt acatatatag tcactggcat     1140



actgagaata tacaatgatc ctggaaattg cagtaacaaa agcacacaac gattatagta     1200



actataagat acaataaaac aaataaatat gaaagtagat tcatgaaaat gtattccttt     1260



aaaatattgt tttcctacag gcctatttaa caagatgttt cattttactg tatattttgt     1320



agttaatata aatgttgctc taatcagatt gcttaaaagc atttttatta tatttatgtt     1380



gttgaactaa tatatgaaat aagtaaatgt agctcccaca aggtaaactt cattggtaag     1440



attgcactgt tctgattatg taagcatttg tacatcttct ttggaaataa aagataaaag     1500



agcgatacac aaagctttct tttctaactt ttccaagcaa aatctaaaat gttttatgac     1560



atttttctgg ctgtgatctt aaaataattc atatctaaat agtattttgt ctaggagatg     1620



ctttctctct agtagttaga aattaaatct gtgtcagcat tcctattaat gtctcacttt     1680



actttcaagt aatattggtg ctatttaaca ttttacagta aatgttactt ctgatacttt     1740



agtacaattt caactacagt gattcatgta gagagacagg ggagttgtca acttgggcta     1800



ctgaactaca tgcataaact aaaaactaac agctacaaac ttttaagatt tctctaatat     1860



tggtatgtaa cacaggataa agttattctt gtcattttga actgtagagt cctatttcag     1920



tgtgatgaat cactgttgct ttgaaaaatc tcattatttc tgggccgggc atggtggctc     1980



acccctgtaa tcccagcact ttgggaggcc aaggcgggtg gatcatgagg tcaggagatc     2040



aagaccatcc tggccaacat ggtgataccc cgtctctact aaaaatacaa aaaaattagt     2100



tgggcatggt ggcatgcacc tgtagtccca gctacctggg aggctgaggc aggagaattg     2160



cttgaacctg ggaggcagag gttgcagtga gccaaaatca tgccactgca ctcccgcctg     2220



gcaacagagc aagagtctgt ctcaaaaaaa aaaagaaaaa aagaaaaaaa gaaaaaagaa     2280



aaatctcatt atttcaaaat gatagacata taccaaaaac aagtctataa tgtgagtagt     2340



tactaaaatt tacacatctt aaaagtgtgt aaatgcttaa atttcagaat taccatcaga     2400



acctcaattg acattccttt gaatacgcta ataagtgaca aataagatta ataagatttt     2460



tcaaaatcgc caggactggt gaatataaat gatgattgaa ctggaataat attggggacc     2520



aaatcaaatg aatgattaaa ttatgaagct catatccttt tgaaggtagt tgcaaagaga     2580



catttcaaaa ctgccctagg ccattgcagc atccttagat gggacgcata atcattacct     2640



taaagcatca ccactcattt tgaccatata gattttatta tgttagttta aaaggtcaat     2700



cagcctcatg actttatagt tatgtcttgt atttaaaaac attttttata catttggtta     2760



tgttgataaa ccaaaaacat ttgattaata aaatatctat ttgaataaat tatgagctat     2820



cctttcaaac agctattggc aagttttaaa cccaaaatat atacacatag ttctgtaata     2880



aaactgtttg acttctcaag taacatgact tccttatttc tgaacagtac tggttacttt     2940



caaaatgaat ttttattgag attttccatt aactattttt ttcaaagact caaattttgt     3000



accaagtaaa tccaggcttt atgtacaaac atgttgtttg ttttatttgg ggctggggga     3060



ggtatatgat gagcagactt ctcggaattc ataataaatt ttctaaaagc ctaaaaaaaa     3120



aaaaaaaaaa aaaaaaaaaa aaaa                                            3144





<210>  365

<211>  112

<212>  PRT

<213>  Homo sapiens



<400>  365



Met Gly Leu Glu Thr Glu Lys Ala Asp Val Gln Leu Phe Met Asp Asp 

1               5                   10                  15      





Asp Ser Tyr Ser His His Ser Gly Leu Glu Tyr Ala Asp Pro Glu Lys 

            20                  25                  30          





Phe Ala Asp Ser Asp Gln Asp Arg Asp Pro His Arg Leu Asn Ser His 

        35                  40                  45              





Leu Lys Asp Phe Asn Ala Phe Cys Lys Asp Leu Pro Asn Gly Ser Ala 

    50                  55                  60                  





Phe Ser Ala Asp Asn Met Glu Glu Cys Asp Arg Cys Tyr His Cys Ser 

65                  70                  75                  80  





Ile Val Tyr Glu Arg Arg Thr Met Leu Leu Phe Cys Gln Pro Ala Thr 

                85                  90                  95      





Glu Pro Gly Leu Asn Thr Trp Thr Pro Gly Leu Glu Ile Gly Ile Leu 

            100                 105                 110         





<210>  366

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  366

agtctgtgcg gtagtgtccc                                                   20





<210>  367

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  367

ctcgtcccac ctgctcaaat                                                   20





<210>  368

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  368

ctcgtcccac ctgctcaaa                                                    19





<210>  369

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  369

gccgcttccc tctttagact                                                   20





<210>  370

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  370

ctcgtcccac ctgctcaaat a                                                 21





<210>  371

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  371

gcttctgttc tgctggctct                                                   20





<210>  372

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  372

gcaacgccac tctctttggg                                                   20





<210>  373

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  373

gctatgggta gggtggttct c                                                 21





<210>  374

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  374

tcgtcccacc tgctcaaata g                                                 21





<210>  375

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  375

gccgcttccc tctttagac                                                    19





<210>  376

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  376

ccttgctcct ctgtcccact                                                   20





<210>  377

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  377

accttgctcc tctgtcccac t                                                 21





<210>  378

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  378

gtccatctcc tcctcctcct                                                   20





<210>  379

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  379

accttgctcc tctgtcccac                                                   20





<210>  380

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  380

cttgctcctc tgtcccact                                                    19





<210>  381

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  381

aaccttgctc ctctgtccca c                                                 21





<210>  382

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  382

cttgctcctc tgtcccactg                                                   20





<210>  383

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  383

tccatctcct cctcctcct                                                    19





<210>  384

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  384

tctcctcctc ctcctgcttc t                                                 21





<210>  385

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  385

ctcctcctcc tcctgcttct                                                   20





<210>  386

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  386

gtcagatgtt ccctccacca                                                   20





<210>  387

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  387

gtcagatgtt ccctccacc                                                    19





<210>  388

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  388

tgtcagatgt tccctccacc                                                   20





<210>  389

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  389

ttgtcagatg ttccctccac c                                                 21





<210>  390

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  390

tcagatgttc cctccacca                                                    19





<210>  391

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  391

tgtcagatgt tccctccacc a                                                 21





<210>  392

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  392

gtcctcttct gggcgtcttg t                                                 21





<210>  393

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  393

gtgtcctgtg ttcgccatc                                                    19





<210>  394

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  394

ttgtcagatg ttccctccac                                                   20





<210>  395

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  395

agactgccac ttccaccacc                                                   20





<210>  396

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  396

gtgtcctgtg gctctgttgg                                                   20





<210>  397

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  397

gtcctgtggc tctgttggca                                                   20





<210>  398

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  398

gggtgtcctg tggctctgtt                                                   20





<210>  399

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  399

tccttcacca ccgccacgtt                                                   20





<210>  400

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  400

tgtcctgtgg ctctgttggc                                                   20





<210>  401

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  401

tgtcctgtgg ctctgttggc a                                                 21





<210>  402

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  402

gccactcatc caagctcact                                                   20





<210>  403

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  403

cttcttcctc agcaccacga                                                   20





<210>  404

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  404

gtgtcctgtg gctctgttg                                                    19





<210>  405

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  405

ctgccatccc actttccagc                                                   20





<210>  406

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  406

gccatcccac tttccagcag                                                   20





<210>  407

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  407

gccatcccac tttccagca                                                    19





<210>  408

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  408

tgccatccca ctttccagc                                                    19





<210>  409

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  409

ccatcccact ttccagcag                                                    19





<210>  410

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  410

gtactgccat cccactttcc a                                                 21





<210>  411

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  411

gtactgccat cccactttcc                                                   20





<210>  412

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  412

ctgccatccc actttccag                                                    19





<210>  413

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  413

actgccatcc cactttccag c                                                 21





<210>  414

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  414

gcatatcctc cagcagccac a                                                 21





<210>  415

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  415

aaccaaccct cccactcca                                                    19





<210>  416

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  416

accaaccctc ccactccaga                                                   20





<210>  417

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  417

aaccaaccct cccactccag                                                   20





<210>  418

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  418

aaccaaccct cccactccag a                                                 21





<210>  419

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  419

gtcccacttc tcgcactag                                                    19





<210>  420

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  420

gtcccacttc tcgcactagc                                                   20





<210>  421

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  421

atccactgcg ttcctcccga                                                   20





<210>  422

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  422

cgtcccactt ctcgcactag                                                   20





<210>  423

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  423

gtctcccttc tgtgtgttc                                                    19





<210>  424

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  424

caccaccacc tcatgttccc                                                   20





<210>  425

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  425

ccaccacctc atgttcccga                                                   20





<210>  426

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  426

gccaccacca cctcatgttc                                                   20





<210>  427

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  427

accaccacct catgttcccg a                                                 21





<210>  428

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  428

gtctcccttc tgtgtgttca                                                   20





<210>  429

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  429

accaccacct catgttcccg                                                   20





<210>  430

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  430

accaccacct catgttccc                                                    19





<210>  431

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  431

cgccaccacc acctcatgtt                                                   20





<210>  432

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  432

cagccagtcc agtccttca                                                    19





<210>  433

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  433

actcccatcc caccctttcc t                                                 21





<210>  434

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  434

actcccatcc caccctttcc                                                   20





<210>  435

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  435

ccactcccat cccacccttt                                                   20





<210>  436

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  436

ctctttaccc actcccatcc c                                                 21





<210>  437

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  437

ctcccatccc accctttcct                                                   20





<210>  438

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  438

cactcccatc ccaccctttc                                                   20





<210>  439

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  439

ttacccactc ccatcccacc                                                   20





<210>  440

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  440

ctcccatccc accctttcct t                                                 21





<210>  441

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  441

tttacccact cccatcccac c                                                 21





<210>  442

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  442

gcccacagtc cattcctctt                                                   20





<210>  443

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  443

gcccacagtc cattcctct                                                    19





<210>  444

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  444

gcccacagtc cattcctctt t                                                 21





<210>  445

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  445

tccagatgct ttcccttccc                                                   20





<210>  446

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  446

ttccagatgc tttcccttcc c                                                 21





<210>  447

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  447

gtcgtgctcc acttcccaca                                                   20





<210>  448

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  448

tctccctcac cctgtcttt                                                    19





<210>  449

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  449

atctccctca ccctgtcttt                                                   20





<210>  450

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  450

gcttgctcac ccaccagtca                                                   20





<210>  451

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  451

atctccctca ccctgtctt                                                    19





<210>  452

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  452

catatctccc tcaccctgtc t                                                 21





<210>  453

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  453

tatctccctc accctgtctt                                                   20





<210>  454

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  454

gcttgctcac ccaccagtca t                                                 21





<210>  455

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  455

atatctccct caccctgtct                                                   20





<210>  456

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  456

tatctccctc accctgtct                                                    19





<210>  457

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  457

tctgcccttc accaccctct                                                   20





<210>  458

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  458

tccctccttg ttgctgccac                                                   20





<210>  459

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  459

ttccctcctt gttgctgcca c                                                 21





<210>  460

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  460

ttccctcctt gttgctgcca                                                   20





<210>  461

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  461

tccctccttg ttgctgcca                                                    19





<210>  462

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  462

tttccctcct tgttgctgcc                                                   20





<210>  463

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  463

tttccctcct tgttgctgcc a                                                 21





<210>  464

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  464

ttccctcctt gttgctgcc                                                    19





<210>  465

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  465

gcctcttctc ccagctcaca                                                   20





<210>  466

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  466

ccttcctttc cagatgttcc c                                                 21





<210>  467

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  467

tccactccct ctcccaccat                                                   20





<210>  468

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  468

tccctctccc accatactcc t                                                 21





<210>  469

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  469

ccctctccca ccatactcct                                                   20





<210>  470

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  470

tccctctccc accatactcc                                                   20





<210>  471

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  471

tccactccct ctcccaccat a                                                 21





<210>  472

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  472

ccactccctc tcccaccata                                                   20





<210>  473

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  473

cctctcccac catactcctc t                                                 21





<210>  474

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  474

cctctcccac catactcctc                                                   20





<210>  475

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  475

ctccctctcc caccatactc                                                   20





<210>  476

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  476

actccctctc ccaccatact c                                                 21





<210>  477

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  477

tctctctcct tccttcacca                                                   20





<210>  478

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  478

ttctctctcc ttccttcacc a                                                 21





<210>  479

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  479

ttctctctcc ttccttcacc                                                   20





<210>  480

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  480

tctctctcct tccttcacc                                                    19





<210>  481

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  481

tttctctctc cttccttcac c                                                 21





<210>  482

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  482

ctctctcctt ccttcacca                                                    19





<210>  483

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  483

tctctctcct tccttcacca t                                                 21





<210>  484

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  484

ctctctcctt ccttcaccat                                                   20





<210>  485

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  485

ctctctcctt ccttcaccat a                                                 21





<210>  486

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  486

tttctctctc cttccttcac                                                   20





<210>  487

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  487

ccttcttctc ttccttccca c                                                 21





<210>  488

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  488

cttcttctct tccttcccac a                                                 21





<210>  489

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  489

cttcttctct tccttcccac                                                   20





<210>  490

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  490

tccttcttct cttccttccc                                                   20





<210>  491

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  491

tccttcttct cttccttccc a                                                 21





<210>  492

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  492

ttcttctctt ccttcccaca                                                   20





<210>  493

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  493

gtcttgtgtc tcccttcctt                                                   20





<210>  494

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  494

ccttcttctc ttccttccca                                                   20





<210>  495

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  495

ttccttcttc tcttccttcc c                                                 21





<210>  496

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  496

tcttctcttc cttcccaca                                                    19





<210>  497

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  497

gtcaccacca ctgtctcca                                                    19





<210>  498

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  498

gtcccatagt ttcatcaggc                                                   20





<210>  499

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  499

ggtcccatag tttcatcagg c                                                 21





<210>  500

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  500

cactctactc tggcactttc a                                                 21





<210>  501

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  501

agttatttca gtcaccacca c                                                 21





<210>  502

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  502

acactctact ctggcacttt c                                                 21





<210>  503

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  503

gttatttcag tcaccaccac                                                   20





<210>  504

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  504

cactctactc tggcactttc                                                   20





<210>  505

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  505

cacactctac tctggcactt t                                                 21





<210>  506

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  506

gcacactcta ctctggcact                                                   20





<210>  507

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  507

tgttgggtgg gtctgggtct                                                   20





<210>  508

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  508

ttgttgggtg ggtctgggtc t                                                 21





<210>  509

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  509

gttgggtggg tctgggtcta                                                   20





<210>  510

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  510

ttgttgggtg ggtctgggtc                                                   20





<210>  511

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  511

tgttgggtgg gtctgggtct a                                                 21





<210>  512

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  512

ttgttgggtg ggtctgggt                                                    19





<210>  513

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  513

attgttgggt gggtctgggt c                                                 21





<210>  514

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  514

attgttgggt gggtctgggt                                                   20





<210>  515

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  515

ttgggtgggt ctgggtcta                                                    19





<210>  516

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  516

acccaccata gagcacccac                                                   20





<210>  517

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  517

gtagccactc tgccagccat                                                   20





<210>  518

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  518

ttaccacagc caccaccacc                                                   20





<210>  519

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  519

attaccacag ccaccaccac c                                                 21





<210>  520

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  520

tagccactct gccagccatg                                                   20





<210>  521

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  521

tagccactct gccagccat                                                    19





<210>  522

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  522

tctgccagcc atgtaccacc t                                                 21





<210>  523

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  523

ctgccagcca tgtaccacct                                                   20





<210>  524

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  524

tctgccagcc atgtaccacc                                                   20





<210>  525

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  525

ctctgccagc catgtaccac                                                   20





<210>  526

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  526

cattaccaca gccaccacca c                                                 21





<210>  527

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  527

ccctcttcct cttcttccc                                                    19





<210>  528

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  528

cccttcttcc tccacttct                                                    19





<210>  529

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  529

cccttcttcc tccacttctg                                                   20





<210>  530

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  530

gctctctact ccactgccag                                                   20





<210>  531

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  531

tctctgtatc ccacggttcc c                                                 21





<210>  532

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  532

gtttctctct gtatcccacg g                                                 21





<210>  533

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  533

cccttcttcc tccacttctg a                                                 21





<210>  534

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  534

ccagcagcca ttccatttcc c                                                 21





<210>  535

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  535

tctctctgta tcccacggtt c                                                 21





<210>  536

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  536

gtttctctct gtatcccacg                                                   20





<210>  537

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  537

gatagtccct cttcttcccg a                                                 21





<210>  538

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  538

gatagtccct cttcttcccg                                                   20





<210>  539

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  539

gatagtccct cttcttccc                                                    19





<210>  540

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  540

tagtccctct tcttcccga                                                    19





<210>  541

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  541

atagtccctc ttcttcccga                                                   20





<210>  542

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  542

agtccctctt cttcccgag                                                    19





<210>  543

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  543

gtcgcagcag atagtccctc t                                                 21





<210>  544

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  544

atagtccctc ttcttcccg                                                    19





<210>  545

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  545

tagtccctct tcttcccgag                                                   20





<210>  546

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  546

ggtcgcagca gatagtccct                                                   20





<210>  547

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  547

ccactccatt cctgtcttcc c                                                 21





<210>  548

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  548

gccactccat tcctgtcttc c                                                 21





<210>  549

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  549

gccactccat tcctgtcttc                                                   20





<210>  550

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  550

tcatccacag tccagcatcc c                                                 21





<210>  551

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  551

catccacagt ccagcatccc a                                                 21





<210>  552

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  552

catccacagt ccagcatccc                                                   20





<210>  553

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  553

gccactccat tcctgtctt                                                    19





<210>  554

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  554

tccacagtcc agcatccca                                                    19





<210>  555

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  555

atccacagtc cagcatccca                                                   20





<210>  556

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  556

tgagtggtgg tggtggtggt                                                   20





<210>  557

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  557

gtggtggctg taggagtcgt                                                   20





<210>  558

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  558

acctcatgat ccacccgcct                                                   20





<210>  559

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  559

cctcatgatc cacccgcctt                                                   20





<210>  560

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  560

tgtggtggct gtaggagtcg t                                                 21





<210>  561

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  561

acctcatgat ccacccgcct t                                                 21





<210>  562

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  562

tggtggctgt aggagtcgtc                                                   20





<210>  563

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  563

gtggctgtag gagtcgtcgt                                                   20





<210>  564

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  564

tctgctcatc atatacctcc c                                                 21





<210>  565

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  565

gctgtggtgg ctgtaggagt                                                   20





<210>  566

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  566

cctgacctca tgatccaccc                                                   20





<210>  567

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  567

gttcttcctc tctccctcca                                                   20





<210>  568

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  568

gttcttcctc tctccctcc                                                    19





<210>  569

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  569

tgttcttcct ctctccctcc                                                   20





<210>  570

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  570

gttgttcttc ctctctccct c                                                 21





<210>  571

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  571

ttgttcttcc tctctccctc c                                                 21





<210>  572

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  572

gttgttcttc ctctctccct                                                   20





<210>  573

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  573

gttcttcctc tctccctcca t                                                 21





<210>  574

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  574

ttcttcctct ctccctcca                                                    19





<210>  575

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  575

tgttgttctt cctctctccc t                                                 21





<210>  576

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  576

ttgttcttcc tctctccctc                                                   20





<210>  577

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  577

actcatccac ctgcttccc                                                    19





<210>  578

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  578

gactcatcca cctgcttccc                                                   20





<210>  579

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  579

gtcttcctcc tccatgccag                                                   20





<210>  580

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  580

tgactcatcc acctgcttcc c                                                 21





<210>  581

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  581

gtcttcctcc tccatgcca                                                    19





<210>  582

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  582

agtcttcctc ctccatgcca                                                   20





<210>  583

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  583

agtcttcctc ctccatgcca g                                                 21





<210>  584

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  584

gtctgtgtct cttcttcttc t                                                 21





<210>  585

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  585

gcctgactca tccacctgct                                                   20





<210>  586

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  586

gtctgtgtct cttcttcttc                                                   20





<210>  587

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  587

ttctcgcctc ctcctcccta                                                   20





<210>  588

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  588

ctgtgtccca tcccttccca                                                   20





<210>  589

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  589

tgtgtcccat cccttcccac                                                   20





<210>  590

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  590

tgtgtcccat cccttccca                                                    19





<210>  591

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  591

atcttctcgc ctcctcctcc                                                   20





<210>  592

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  592

tctcgcctcc tcctccctaa                                                   20





<210>  593

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  593

ccatcttctc gcctcctcct                                                   20





<210>  594

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  594

ttctcgcctc ctcctcccta a                                                 21





<210>  595

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  595

catcttctcg cctcctcctc                                                   20





<210>  596

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  596

gtgtagggct gggtctggtt                                                   20





<210>  597

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  597

gtatgcgtct cctcctcca                                                    19





<210>  598

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  598

gtatgcgtct cctcctccat c                                                 21





<210>  599

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  599

ctcccggctc ttctctgcaa                                                   20





<210>  600

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  600

gtcagtatgc gtctcctcct c                                                 21





<210>  601

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  601

tcagtatgcg tctcctcctc c                                                 21





<210>  602

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  602

cagtatgcgt ctcctcctcc a                                                 21





<210>  603

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  603

cagtatgcgt ctcctcctcc                                                   20





<210>  604

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  604

tcccggctct tctctgcaac a                                                 21





<210>  605

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  605

gtatgcgtct cctcctccat                                                   20





<210>  606

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  606

tcccggctct tctctgcaac                                                   20





<210>  607

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  607

tccacccttc ccttcagca                                                    19





<210>  608

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  608

atccaccctt cccttcagca                                                   20





<210>  609

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  609

atccaccctt cccttcagc                                                    19





<210>  610

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  610

tccctcagac tccacagcac                                                   20





<210>  611

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  611

tccacccttc ccttcagcaa                                                   20





<210>  612

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  612

tccctcagac tccacagca                                                    19





<210>  613

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  613

atccaccctt cccttcagca a                                                 21





<210>  614

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  614

aatccaccct tcccttcagc a                                                 21





<210>  615

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  615

aatccaccct tcccttcagc                                                   20





<210>  616

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  616

ccacccttcc cttcagcaa                                                    19





<210>  617

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  617

tcttccctct ctcactctct                                                   20





<210>  618

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  618

tcttccctct ctcactctct t                                                 21





<210>  619

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  619

ttcttccctc tctcactctc t                                                 21





<210>  620

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  620

cttccctctc tcactctctt                                                   20





<210>  621

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  621

ttcttccctc tctcactctc                                                   20





<210>  622

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  622

cttccctctc tcactctct                                                    19





<210>  623

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  623

cttccctctc tcactctctt t                                                 21





<210>  624

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  624

tttcttccct ctctcactct c                                                 21





<210>  625

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  625

tcttccctct ctcactctc                                                    19





<210>  626

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  626

ttccctctct cactctcttt                                                   20





<210>  627

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  627

gtatgtcact ccaccctgt                                                    19





<210>  628

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  628

gcctaagtcc cagagtccag                                                   20





<210>  629

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  629

gcctaagtcc cagagtcca                                                    19





<210>  630

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  630

ggtgccagtg tcggtcttca                                                   20





<210>  631

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  631

gtgccagtgt cggtcttca                                                    19





<210>  632

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  632

acttcccagg cacccatagg                                                   20





<210>  633

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  633

acacatactt gcctccaccg a                                                 21





<210>  634

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  634

gccgctgtct gtctggatgt                                                   20





<210>  635

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  635

cacatacttg cctccaccga                                                   20





<210>  636

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  636

gacttcccag gcacccatag                                                   20





<210>  637

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  637

ctctttctgg tctctgttct                                                   20





<210>  638

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  638

ctctttctgg tctctgttct t                                                 21





<210>  639

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  639

tctttctggt ctctgttctt c                                                 21





<210>  640

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  640

gtgttccctg ttgtcttact                                                   20





<210>  641

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  641

ctttctggtc tctgttcttc                                                   20





<210>  642

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  642

ctctttctgg tctctgttc                                                    19





<210>  643

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  643

catcttctgc tccacttcca                                                   20





<210>  644

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  644

gtgttccctg ttgtcttact g                                                 21





<210>  645

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  645

gtgttccctg ttgtcttac                                                    19





<210>  646

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  646

ctttcttctc ctcctcctct c                                                 21





<210>  647

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  647

tctcctcctc ctctcgcttc t                                                 21





<210>  648

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  648

tcttctcctc ctcctctcgc t                                                 21





<210>  649

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  649

ctccagttct tcctccaccc t                                                 21





<210>  650

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  650

tctccagttc ttcctccacc c                                                 21





<210>  651

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  651

ctttcttctc ctcctcctct                                                   20





<210>  652

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  652

tttcttctcc tcctcctctc                                                   20





<210>  653

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  653

ctcctcctcc tctcgcttct                                                   20





<210>  654

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  654

cttctcctcc tcctctcgct                                                   20





<210>  655

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  655

tctcctcctc ctctcgcttc                                                   20





<210>  656

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  656

gcacctccca gccttcttca                                                   20





<210>  657

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  657

cacctcccag ccttcttcag                                                   20





<210>  658

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  658

tcaccactgt cccgcttcca                                                   20





<210>  659

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  659

cacctcccag ccttcttca                                                    19





<210>  660

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  660

acctcccagc cttcttcag                                                    19





<210>  661

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  661

tcttgtcgtc cagtgtgccc                                                   20





<210>  662

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  662

gttcttgtcg tccagtgtgc c                                                 21





<210>  663

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  663

caccactgtc ccgcttccaa                                                   20





<210>  664

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  664

ttcttgtcgt ccagtgtgcc c                                                 21





<210>  665

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  665

agtcaccact gtcccgcttc                                                   20





<210>  666

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  666

cccattctgc tctgtccctg t                                                 21





<210>  667

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  667

tttcttcctc ctcccatcca                                                   20





<210>  668

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  668

ttcttcctcc tcccatcca                                                    19





<210>  669

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  669

tttcttcctc ctcccatcc                                                    19





<210>  670

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  670

cccattctgc tctgtccctg                                                   20





<210>  671

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  671

cccattctgc tctgtccct                                                    19





<210>  672

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  672

ccattctgct ctgtccctgt                                                   20





<210>  673

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  673

ttcttcctcc tcccatccaa                                                   20





<210>  674

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  674

gcccattctg ctctgtccct                                                   20





<210>  675

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  675

tttcttcctc ctcccatcca a                                                 21





<210>  676

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  676

tctgggtctg tgtggtctgg t                                                 21





<210>  677

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  677

accacatccc acactccta                                                    19





<210>  678

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  678

gtcttctggg tctgtgtggt c                                                 21





<210>  679

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  679

ctgggtctgt gtggtctggt                                                   20





<210>  680

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  680

tcctcccaca gctccttcca                                                   20





<210>  681

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  681

cctcatttcc tcccacagc                                                    19





<210>  682

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  682

gcctcatttc ctcccacag                                                    19





<210>  683

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  683

gtcttctggg tctgtgtggt                                                   20





<210>  684

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  684

ccacatccca cactcctatg c                                                 21





<210>  685

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  685

accacatccc acactcctat                                                   20





<210>  686

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  686

tcctcccagc catgtttgtg c                                                 21





<210>  687

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  687

ctcccagcca tgtttgtgcc                                                   20





<210>  688

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  688

cctcccagcc atgtttgtgc                                                   20





<210>  689

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  689

ctcccagcca tgtttgtgcc a                                                 21





<210>  690

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  690

ccaattcctc ccagccatgt                                                   20





<210>  691

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  691

ccaattcctc ccagccatgt t                                                 21





<210>  692

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  692

tcccagccat gtttgtgcca                                                   20





<210>  693

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  693

tcctcccagc catgtttgtg                                                   20





<210>  694

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  694

ttcctcccag ccatgtttgt                                                   20





<210>  695

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  695

tcctcccagc catgtttgt                                                    19





<210>  696

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  696

tcctcccagc catgtttgtg c                                                 21





<210>  697

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  697

ctcccagcca tgtttgtgcc                                                   20





<210>  698

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  698

cctcccagcc atgtttgtgc                                                   20





<210>  699

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  699

ctcccagcca tgtttgtgcc a                                                 21





<210>  700

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  700

ccaattcctc ccagccatgt                                                   20





<210>  701

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  701

ccaattcctc ccagccatgt t                                                 21





<210>  702

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  702

tcccagccat gtttgtgcca                                                   20





<210>  703

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  703

tcctcccagc catgtttgtg                                                   20





<210>  704

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  704

ttcctcccag ccatgtttgt                                                   20





<210>  705

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  705

tcctcccagc catgtttgt                                                    19





<210>  706

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  706

cccagcctca cagttccttc t                                                 21





<210>  707

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  707

cccagcctca cagttccttc                                                   20





<210>  708

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  708

ccagcctcac agttccttct                                                   20





<210>  709

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  709

cccagcctca cagttcctt                                                    19





<210>  710

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  710

ccagcctcac agttccttc                                                    19





<210>  711

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  711

ccagcctcac agttccttct g                                                 21





<210>  712

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  712

cagcctcaca gttccttct                                                    19





<210>  713

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  713

gggtctctgg cttagaaggg a                                                 21





<210>  714

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  714

gggtctctgg cttagaaggg                                                   20





<210>  715

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  715

agggtctctg gcttagaagg g                                                 21





<210>  716

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  716

gtctcattcc acaagcctct                                                   20





<210>  717

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  717

cgtctcattc cacaagcctc t                                                 21





<210>  718

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  718

gtctcattcc acaagcctct a                                                 21





<210>  719

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  719

gttctgtttc tctgttgtc                                                    19





<210>  720

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  720

caccgcccac agaacctcat                                                   20





<210>  721

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  721

cctctttcct ttcctttcca c                                                 21





<210>  722

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  722

gtctctcctg ctgctccctt                                                   20





<210>  723

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  723

tgtctctcct gctgctccct                                                   20





<210>  724

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  724

ctctttcctt tcctttccac t                                                 21





<210>  725

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  725

tgtctctcct gctgctccct t                                                 21





<210>  726

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  726

ctctttcctt tcctttccac                                                   20





<210>  727

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  727

cctctttcct ttcctttcca                                                   20





<210>  728

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  728

tctctcctgc tgctcccttg                                                   20





<210>  729

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  729

tctctcctgc tgctccctt                                                    19





<210>  730

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  730

gtcagcagca tcccacctat c                                                 21





<210>  731

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  731

cccattcctg ccacctctca                                                   20





<210>  732

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  732

ctcctcctgc ttcttctccc                                                   20





<210>  733

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  733

ctcctcctgc ttcttctccc a                                                 21





<210>  734

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  734

cctttccctc cgctttcctg t                                                 21





<210>  735

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  735

tctccttctc ctccgcctct                                                   20





<210>  736

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  736

ccattcctgc cacctctcac                                                   20





<210>  737

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  737

ccattcctgc cacctctcac a                                                 21





<210>  738

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  738

tcctcctgct tcttctccc                                                    19





<210>  739

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  739

tcctcctgct tcttctccca                                                   20





<210>  740

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  740

cctttcctcc tgctcccttt                                                   20





<210>  741

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  741

cctttcctcc tgctccctt                                                    19





<210>  742

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  742

cctttcctcc tgctcccttt a                                                 21





<210>  743

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  743

gcctttcctc ctgctccctt                                                   20





<210>  744

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  744

ctttcctcct gctcccttt                                                    19





<210>  745

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  745

gcctttcctc ctgctccctt t                                                 21





<210>  746

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  746

ctttcctcct gctcccttta                                                   20





<210>  747

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  747

ctttcctcct gctcccttta t                                                 21





<210>  748

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  748

tttcctcctg ctccctttat                                                   20





<210>  749

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  749

tttcctcctg ctcccttta                                                    19





<210>  750

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  750

tcctctcagc ctttcctccc t                                                 21





<210>  751

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  751

cctctcagcc tttcctccct                                                   20





<210>  752

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  752

tcctctcagc ctttcctccc                                                   20





<210>  753

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  753

cctctcagcc tttcctccct t                                                 21





<210>  754

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  754

cctcccatcc tctcagcctt                                                   20





<210>  755

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  755

atcctctcag cctttcctcc c                                                 21





<210>  756

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  756

cctttcctcc ctttctcttg                                                   20





<210>  757

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  757

cctcccatcc tctcagcctt t                                                 21





<210>  758

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  758

tcccatcctc tcagcctttc c                                                 21





<210>  759

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  759

cctttcctcc ctttctctt                                                    19





<210>  760

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  760

ccagttcctc ccagtcttgc                                                   20





<210>  761

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  761

cccagttcct cccagtcttg                                                   20





<210>  762

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  762

cccagttcct cccagtctt                                                    19





<210>  763

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  763

cagttcctcc cagtcttgc                                                    19





<210>  764

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  764

ccagttcctc ccagtcttgc a                                                 21





<210>  765

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  765

acccatccac tcacaagccg                                                   20





<210>  766

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  766

ccagttcctc ccagtcttg                                                    19





<210>  767

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  767

agtcccttgc catgttcac                                                    19





<210>  768

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  768

acccatccac tcacaagcc                                                    19





<210>  769

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  769

actcctcaac cctcttctca                                                   20





<210>  770

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  770

ctgcttcttc cctctccttc                                                   20





<210>  771

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  771

gcttcttccc tctccttcag t                                                 21





<210>  772

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  772

gcttcttccc tctccttcag                                                   20





<210>  773

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  773

aacctcctct tcccttccc                                                    19





<210>  774

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  774

gctgcttctt ccctctcctt c                                                 21





<210>  775

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  775

ctgcttcttc cctctccttc a                                                 21





<210>  776

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  776

gcttcttccc tctccttca                                                    19





<210>  777

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  777

gctgcttctt ccctctcctt                                                   20





<210>  778

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  778

gctgcttctt ccctctcct                                                    19





<210>  779

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  779

tgcttcttcc ctctccttca                                                   20





<210>  780

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  780

actccttctc ctccctctg                                                    19





<210>  781

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  781

aactccttct cctccctctg                                                   20





<210>  782

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  782

actccttctc ctccctctgg                                                   20





<210>  783

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  783

aactccttct cctccctct                                                    19





<210>  784

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  784

aactccttct cctccctctg g                                                 21





<210>  785

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  785

gaactccttc tcctccctct                                                   20





<210>  786

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  786

gaactccttc tcctccctct g                                                 21





<210>  787

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  787

gtttgctgta ctccctctg                                                    19





<210>  788

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  788

gtttgctgta ctccctctgc                                                   20





<210>  789

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  789

gccagcttcc tcttctcctc                                                   20





<210>  790

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  790

gctgaaccac tccctctacc t                                                 21





<210>  791

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  791

gctgaaccac tccctctacc                                                   20





<210>  792

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  792

accactccct ctaccttta                                                    19





<210>  793

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  793

tgctgaacca ctccctctac c                                                 21





<210>  794

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  794

ctgaaccact ccctctacct                                                   20





<210>  795

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  795

ccactccctc tacctttagc                                                   20





<210>  796

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  796

gaaccactcc ctctaccttt                                                   20





<210>  797

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  797

accactccct ctacctttag c                                                 21





<210>  798

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  798

ctgaaccact ccctctacct t                                                 21





<210>  799

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  799

ccactccctc tacctttagc g                                                 21





<210>  800

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  800

tcttgctgtg tttcccattc c                                                 21





<210>  801

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  801

cttgctgtgt ttcccattcc                                                   20





<210>  802

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  802

gctttggtca ctctgctcct c                                                 21





<210>  803

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  803

gttcttgctg tgtttcccat                                                   20





<210>  804

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  804

gtgtttccca ttccagtctt                                                   20





<210>  805

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  805

gttcttgctg tgtttccca                                                    19





<210>  806

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  806

gttcttgctg tgtttcccat t                                                 21





<210>  807

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  807

agttcttgct gtgtttccca                                                   20





<210>  808

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  808

gtgtttccca ttccagtct                                                    19





<210>  809

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  809

tgtgtttccc attccagtct                                                   20





<210>  810

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  810

tccagcctca tctctcagcc a                                                 21





<210>  811

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  811

ccagcctcat ctctcagcca                                                   20





<210>  812

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  812

gtccagcctc atctctcagc                                                   20





<210>  813

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  813

tccagcctca tctctcagcc                                                   20





<210>  814

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  814

cctcagcact tcctcatctc c                                                 21





<210>  815

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  815

agcctcatct ctcagccagg                                                   20





<210>  816

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  816

ccttcccgcc actgcatgta                                                   20





<210>  817

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  817

cagcctcatc tctcagccag                                                   20





<210>  818

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  818

gtccagcctc atctctcag                                                    19





<210>  819

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  819

ccttggtcag ctcctcctct                                                   20





<210>  820

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  820

accctccttc ttcctctccc                                                   20





<210>  821

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  821

gttccactcc ctctactcct                                                   20





<210>  822

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  822

gttccactcc ctctactcct g                                                 21





<210>  823

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  823

ttccactccc tctactcct                                                    19





<210>  824

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  824

taccctcctt cttcctctcc c                                                 21





<210>  825

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  825

gttccactcc ctctactcc                                                    19





<210>  826

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  826

ttccactccc tctactcctg                                                   20





<210>  827

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  827

tgttccactc cctctactcc t                                                 21





<210>  828

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  828

tccactccct ctactcctg                                                    19





<210>  829

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  829

tgttccactc cctctactcc                                                   20





<210>  830

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  830

tttccacgct ctctcccgct                                                   20





<210>  831

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  831

ttccacgctc tctcccgcta                                                   20





<210>  832

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  832

tttccacgct ctctcccgct a                                                 21





<210>  833

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  833

gtccatgtcc tctgtatgcc a                                                 21





<210>  834

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  834

ccatgaactc tccagcctcc t                                                 21





<210>  835

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  835

ccatgaactc tccagcctcc                                                   20





<210>  836

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  836

gctgctgggc tctgtcttct                                                   20





<210>  837

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  837

accatgaact ctccagcctc c                                                 21





<210>  838

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  838

gtccatgtcc tctgtatgcc                                                   20





<210>  839

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  839

tccatgtcct ctgtatgcca                                                   20





<210>  840

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  840

actcaccctc tctcactccc                                                   20





<210>  841

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  841

gctcctcctc aaccttccct                                                   20





<210>  842

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  842

actcaccctc tctcactcc                                                    19





<210>  843

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  843

ctcctcctca accttccctc                                                   20





<210>  844

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  844

tcctcctcaa ccttccctcg                                                   20





<210>  845

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  845

ctcctcctca accttccct                                                    19





<210>  846

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  846

gactcaccct ctctcactcc                                                   20





<210>  847

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  847

tcctcctcaa ccttccctc                                                    19





<210>  848

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  848

ctcctcaacc ttccctcgct                                                   20





<210>  849

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  849

tcctcaacct tccctcgctg                                                   20





<210>  850

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  850

ctctgtcagc cactcaccca                                                   20





<210>  851

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  851

ctctgccact tgataccctc c                                                 21





<210>  852

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  852

cctctgccac ttgataccct c                                                 21





<210>  853

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  853

gccacttgat accctccttc t                                                 21





<210>  854

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  854

tccaccacga cccaatccct                                                   20





<210>  855

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  855

cctctgccac ttgataccct                                                   20





<210>  856

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  856

gccacttgat accctccttc                                                   20





<210>  857

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  857

tctgtcagcc actcacccag                                                   20





<210>  858

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  858

ctgtcagcca ctcacccaga                                                   20





<210>  859

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  859

tctgccactt gataccctcc t                                                 21





<210>  860

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  860

gcccacagtc accatgttct c                                                 21





<210>  861

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  861

cccacagtca ccatgttctc c                                                 21





<210>  862

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  862

gcccacagtc accatgttct                                                   20





<210>  863

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  863

gctgctgatg ttgtacttcc c                                                 21





<210>  864

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  864

agcccacagt caccatgttc                                                   20





<210>  865

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  865

aaggagttct gcggtgccac                                                   20





<210>  866

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  866

gcccacagtc accatgttc                                                    19





<210>  867

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  867

ggtagtcctc gctgctgatg t                                                 21





<210>  868

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  868

ccacagtcac catgttctcc a                                                 21





<210>  869

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  869

gtttctcctc ctcgcgcatc t                                                 21





<210>  870

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  870

gttcccattc cacctgcctg                                                   20





<210>  871

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  871

gttcccattc cacctgcct                                                    19





<210>  872

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  872

gagttcccat tccacctgcc t                                                 21





<210>  873

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  873

ccagagagtt cccattccac c                                                 21





<210>  874

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  874

ttcccattcc acctgcctg                                                    19





<210>  875

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  875

gagttcccat tccacctgcc                                                   20





<210>  876

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  876

agttcccatt ccacctgcct                                                   20





<210>  877

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  877

agttcccatt ccacctgcct g                                                 21





<210>  878

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  878

agagttccca ttccacctgc c                                                 21





<210>  879

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  879

agttcccatt ccacctgcc                                                    19





<210>  880

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  880

ctcttgtact ccctgccacc                                                   20





<210>  881

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  881

tcttgtactc cctgccaccc                                                   20





<210>  882

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  882

tcttgtactc cctgccaccc a                                                 21





<210>  883

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  883

cctgtcttcc ctccttctcc                                                   20





<210>  884

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  884

ccctgtcttc cctccttctc                                                   20





<210>  885

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  885

tgtactccct gccacccact                                                   20





<210>  886

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  886

cttgtactcc ctgccaccca                                                   20





<210>  887

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  887

ttgtactccc tgccacccac t                                                 21





<210>  888

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  888

ttgtactccc tgccacccac                                                   20





<210>  889

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  889

ccctgtcttc cctccttct                                                    19





<210>  890

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  890

tcctcctctt ctgccaccca                                                   20





<210>  891

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  891

atcctcctct tctgccaccc                                                   20





<210>  892

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  892

atcctcctct tctgccaccc a                                                 21





<210>  893

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  893

gtcatcctcc tcttctgcca c                                                 21





<210>  894

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  894

tcatcctcct cttctgccac c                                                 21





<210>  895

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  895

catcctcctc ttctgccacc                                                   20





<210>  896

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  896

ctgtcttctc ctccttcctc t                                                 21





<210>  897

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  897

gtcttctcct ccttcctct                                                    19





<210>  898

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  898

tgtcttctcc tccttcctct                                                   20





<210>  899

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  899

atcctcctct tctgccacc                                                    19





<210>  900

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  900

cattccactc ccatgtatcc a                                                 21





<210>  901

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  901

ttccactccc atgtatccag                                                   20





<210>  902

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  902

cattccactc ccatgtatcc                                                   20





<210>  903

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  903

attccactcc catgtatcca g                                                 21





<210>  904

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  904

tccactccca tgtatccag                                                    19





<210>  905

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  905

attccactcc catgtatcca                                                   20





<210>  906

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  906

ccactcccat gtatccaga                                                    19





<210>  907

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  907

ttccactccc atgtatcca                                                    19





<210>  908

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  908

ccactcccat gtatccagat                                                   20





<210>  909

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  909

tccactccca tgtatccaga                                                   20





<210>  910

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  910

actctgccgc cttcttctcc                                                   20





<210>  911

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  911

cttcttctcc cgccgcttct                                                   20





<210>  912

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  912

tcttctcccg ccgcttcttc                                                   20





<210>  913

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  913

cttcttctcc cgccgcttct t                                                 21





<210>  914

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  914

ctcgcagtag tcccagtcgt                                                   20





<210>  915

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  915

ttcttctccc gccgcttctt c                                                 21





<210>  916

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  916

ttcttctccc gccgcttctt                                                   20





<210>  917

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  917

tcttctcccg ccgcttctt                                                    19





<210>  918

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  918

ttcttctccc gccgcttct                                                    19





<210>  919

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  919

tcgcagtagt cccagtcgtg                                                   20





<210>  920

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  920

tcctcctctc caccttctcc                                                   20





<210>  921

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  921

tcctcctctc caccttctcc a                                                 21





<210>  922

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  922

cctcctctcc accttctcca                                                   20





<210>  923

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  923

cccatcctcc tctccacctt                                                   20





<210>  924

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  924

atcctcctct ccaccttctc c                                                 21





<210>  925

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  925

cctcctctcc aactcatccc t                                                 21





<210>  926

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  926

tcctcctctc caccttctc                                                    19





<210>  927

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  927

cctcctctcc accttctcca t                                                 21





<210>  928

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  928

ccatcctcct ctccaccttc t                                                 21





<210>  929

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  929

cctcctctcc aactcatccc                                                   20





<210>  930

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  930

tccacacgcc attctcccat c                                                 21





<210>  931

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  931

ccacacgcca ttctcccatc                                                   20





<210>  932

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  932

ttccacacgc cattctccca                                                   20





<210>  933

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  933

tccacacgcc attctcccat                                                   20





<210>  934

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  934

tttccacacg ccattctccc a                                                 21





<210>  935

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  935

tccacacgcc attctccca                                                    19





<210>  936

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  936

tttccacacg ccattctccc                                                   20





<210>  937

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  937

ttccacacgc cattctccca t                                                 21





<210>  938

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  938

ttccacacgc cattctccc                                                    19





<210>  939

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  939

ccacacgcca ttctcccat                                                    19





<210>  940

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  940

tttcccgaac agccgccaca                                                   20





<210>  941

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  941

ttcccgaaca gccgccacaa                                                   20





<210>  942

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  942

tttcccgaac agccgccaca a                                                 21





<210>  943

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  943

cagccagccg agtcctttgt                                                   20





<210>  944

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  944

gccagccgag tcctttgtga                                                   20





<210>  945

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  945

agccagccga gtcctttgtg a                                                 21





<210>  946

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  946

agccagccga gtcctttgtg                                                   20





<210>  947

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  947

agccagccga gtcctttgt                                                    19





<210>  948

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  948

tctgcactct cattccacca                                                   20





<210>  949

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  949

actttcccga acagccgcca                                                   20





<210>  950

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  950

cctccttccc accacttgct                                                   20





<210>  951

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  951

gctacctcct tcccaccact                                                   20





<210>  952

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  952

ctacctcctt cccaccactt                                                   20





<210>  953

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  953

acctccttcc caccacttgc t                                                 21





<210>  954

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  954

cctccttccc accacttgct t                                                 21





<210>  955

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  955

ctacctcctt cccaccact                                                    19





<210>  956

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  956

gctacctcct tcccaccact t                                                 21





<210>  957

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  957

acctccttcc caccacttgc                                                   20





<210>  958

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  958

tcccaccact tgcttctctc t                                                 21





<210>  959

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  959

ccttcccacc acttgcttct c                                                 21





<210>  960

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  960

tccaccatcc accctccatc                                                   20





<210>  961

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  961

tccaccatcc accctccatc a                                                 21





<210>  962

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  962

ccaccatcca ccctccatca                                                   20





<210>  963

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  963

catccaccat ccaccctcca                                                   20





<210>  964

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  964

acatccacca tccaccctcc                                                   20





<210>  965

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  965

atccaccatc caccctccat c                                                 21





<210>  966

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  966

acatccacca tccaccctcc a                                                 21





<210>  967

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  967

catccaccat ccaccctcca t                                                 21





<210>  968

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  968

atccaccatc caccctccat                                                   20





<210>  969

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  969

tccaccatcc accctccat                                                    19





<210>  970

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  970

gcccatccac cttcatctat                                                   20





<210>  971

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  971

gcccatccac cttcatcta                                                    19





<210>  972

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  972

agcccatcca ccttcatct                                                    19





<210>  973

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  973

tcaccacttc agcccattca                                                   20





<210>  974

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  974

agcccatcca ccttcatcta                                                   20





<210>  975

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  975

atcaccactt cagcccattc a                                                 21





<210>  976

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  976

gcccatccac cttcatctat g                                                 21





<210>  977

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  977

agcccatcca ccttcatcta t                                                 21





<210>  978

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  978

atcaccactt cagcccattc                                                   20





<210>  979

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  979

gcttgatctc tctctatccc a                                                 21





<210>  980

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  980

gtttctcttc tgtccttccc                                                   20





<210>  981

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  981

cacctccacc acctactcca                                                   20





<210>  982

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  982

tgtttctctt ctgtccttcc c                                                 21





<210>  983

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  983

acctccacca cctactcca                                                    19





<210>  984

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  984

tcttgccacc tccaccacct                                                   20





<210>  985

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  985

acctccacca cctactccag                                                   20





<210>  986

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  986

atcttgccac ctccaccacc t                                                 21





<210>  987

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  987

tcttgccacc tccaccacct a                                                 21





<210>  988

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  988

tctcatcttg ccacctccac c                                                 21





<210>  989

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  989

atcttgccac ctccaccacc                                                   20





<210>  990

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  990

ctcttctcca tctcctccca c                                                 21





<210>  991

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  991

tcttctccat ctcctcccac                                                   20





<210>  992

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  992

tcttctccat ctcctcccac a                                                 21





<210>  993

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  993

cttctccatc tcctcccaca                                                   20





<210>  994

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  994

tctcttctcc atctcctccc                                                   20





<210>  995

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  995

tctcttctcc atctcctccc a                                                 21





<210>  996

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  996

ctcttctcca tctcctccca                                                   20





<210>  997

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  997

cttctccatc tcctcccac                                                    19





<210>  998

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  998

ctcttctcca tctcctccc                                                    19





<210>  999

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  999

ttctccatct cctcccaca                                                    19





<210>  1000

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1000

gctgctctca cctcccagaa                                                   20





<210>  1001

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1001

gttctgggct gctctcacct                                                   20





<210>  1002

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1002

ttctgggctg ctctcacctc                                                   20





<210>  1003

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1003

ctgctctcac ctcccagaa                                                    19





<210>  1004

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1004

gtctcagcat ttccaccttg                                                   20





<210>  1005

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1005

gctccagctc tgtcagtgtc t                                                 21





<210>  1006

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1006

agtctcagca tttccacctt                                                   20





<210>  1007

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1007

agtctcagca tttccacctt g                                                 21





<210>  1008

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1008

gctctgtcag tgtctgggtg t                                                 21





<210>  1009

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1009

gtctcagcat ttccacctt                                                    19





<210>  1010

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1010

tcccacttcc caagccctca                                                   20





<210>  1011

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1011

atcccacttc ccaagccctc                                                   20





<210>  1012

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1012

atcccacttc ccaagccctc a                                                 21





<210>  1013

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1013

gatcccactt cccaagccct                                                   20





<210>  1014

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1014

tgccaccctc ctcccacaaa                                                   20





<210>  1015

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1015

agatcccact tcccaagccc t                                                 21





<210>  1016

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1016

agatcccact tcccaagccc                                                   20





<210>  1017

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1017

atcccacttc ccaagccct                                                    19





<210>  1018

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1018

ccacttccca agccctcaga                                                   20





<210>  1019

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1019

gcactcgatc ccacttcctt                                                   20





<210>  1020

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1020

ctccacttcc tcttgctcct c                                                 21





<210>  1021

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1021

tccacttcct cttgctcctc t                                                 21





<210>  1022

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1022

tctccacttc ctcttgctcc t                                                 21





<210>  1023

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1023

ccacttcctc ttgctcctct                                                   20





<210>  1024

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1024

ctccacttcc tcttgctcct                                                   20





<210>  1025

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1025

tccacttcct cttgctcctc                                                   20





<210>  1026

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1026

tctccacttc ctcttgctcc                                                   20





<210>  1027

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1027

ccacttcctc ttgctcctct t                                                 21





<210>  1028

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1028

gttctccact tcctcttgct c                                                 21





<210>  1029

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1029

ttctccactt cctcttgctc c                                                 21





<210>  1030

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1030

gtctcccagt ccaccatcac                                                   20





<210>  1031

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1031

ctttcctgcc actttccctt c                                                 21





<210>  1032

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1032

gtctcccagt ccaccatca                                                    19





<210>  1033

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1033

gactttcctg ccactttccc t                                                 21





<210>  1034

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1034

ttcctgccac tttcccttca                                                   20





<210>  1035

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1035

gactttcctg ccactttccc                                                   20





<210>  1036

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1036

actttcctgc cactttccct                                                   20





<210>  1037

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1037

ctttcctgcc actttccctt                                                   20





<210>  1038

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1038

tcctgccact ttcccttca                                                    19





<210>  1039

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1039

tttcctgcca ctttcccttc a                                                 21





<210>  1040

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1040

cgtcccaagg ctctctctca                                                   20





<210>  1041

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1041

gtcccaaggc tctctctca                                                    19





<210>  1042

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1042

ctctcacaac tcatctttcc c                                                 21





<210>  1043

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1043

gtcccaaggc tctctctcaa                                                   20





<210>  1044

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1044

cgtcccaagg ctctctctca a                                                 21





<210>  1045

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1045

acccaaaccc tccaatccc                                                    19





<210>  1046

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1046

tctcacaact catctttccc t                                                 21





<210>  1047

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1047

tacccaaacc ctccaatccc                                                   20





<210>  1048

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1048

gtacccaaac cctccaatcc c                                                 21





<210>  1049

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1049

ctcacaactc atctttccct                                                   20





<210>  1050

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1050

tcccacattc atccacctcc c                                                 21





<210>  1051

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1051

cccacattca tccacctccc                                                   20





<210>  1052

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1052

ctcccacatt catccacctc c                                                 21





<210>  1053

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1053

tcccacattc atccacctcc                                                   20





<210>  1054

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1054

gtccaccgtt gtcccatgct                                                   20





<210>  1055

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1055

tctcccacat tcatccacct c                                                 21





<210>  1056

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1056

ccacattcat ccacctcccg                                                   20





<210>  1057

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1057

tgtccaccgt tgtcccatgc t                                                 21





<210>  1058

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1058

ctcccacatt catccacctc                                                   20





<210>  1059

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1059

ccacattcat ccacctccc                                                    19





<210>  1060

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1060

tctttgtgcc cttcctccct                                                   20





<210>  1061

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1061

tcatcacatc tcccacagcc a                                                 21





<210>  1062

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1062

tcacatctcc cacagccaac c                                                 21





<210>  1063

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1063

tctttgtgcc cttcctccct g                                                 21





<210>  1064

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1064

catcacatct cccacagcca                                                   20





<210>  1065

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1065

cacatctccc acagccaacc a                                                 21





<210>  1066

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1066

atctttgtgc ccttcctccc t                                                 21





<210>  1067

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1067

ctttgtgccc ttcctccctg                                                   20





<210>  1068

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1068

cacatctccc acagccaacc                                                   20





<210>  1069

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1069

gtcatcacat ctcccacagc c                                                 21





<210>  1070

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1070

ataccctgtc cctccctga                                                    19





<210>  1071

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1071

tataccctgt ccctccctga                                                   20





<210>  1072

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1072

ttataccctg tccctccctg a                                                 21





<210>  1073

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1073

ccctgtccct ccctgaaatg t                                                 21





<210>  1074

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1074

cattataccc tgtccctccc t                                                 21





<210>  1075

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1075

tcattatacc ctgtccctcc c                                                 21





<210>  1076

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1076

ttataccctg tccctccctg                                                   20





<210>  1077

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1077

tataccctgt ccctccctg                                                    19





<210>  1078

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1078

attataccct gtccctccct                                                   20





<210>  1079

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1079

ttataccctg tccctccct                                                    19





<210>  1080

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1080

cctcccacag tcctaagcct                                                   20





<210>  1081

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1081

ctcccacagt cctaagcct                                                    19





<210>  1082

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1082

gctcctcagt cttcttgccc                                                   20





<210>  1083

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1083

ctccacttct tcttgcttct                                                   20





<210>  1084

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1084

ctcctcagtc ttcttgccc                                                    19





<210>  1085

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1085

ctcttccact tattacctgc c                                                 21





<210>  1086

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1086

ctccacttct tcttgcttct t                                                 21





<210>  1087

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1087

tcttccactt attacctgcc a                                                 21





<210>  1088

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1088

cttccactta ttacctgcca c                                                 21





<210>  1089

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1089

gctgctccac ttcttcttgc t                                                 21





<210>  1090

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1090

attcccacag ccatcacca                                                    19





<210>  1091

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1091

gattcccaca gccatcacca                                                   20





<210>  1092

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1092

gattcccaca gccatcacc                                                    19





<210>  1093

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1093

ttcccacagc catcaccaat                                                   20





<210>  1094

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1094

attcccacag ccatcaccaa                                                   20





<210>  1095

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1095

ttcccacagc catcaccaa                                                    19





<210>  1096

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1096

attcccacag ccatcaccaa t                                                 21





<210>  1097

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1097

tcccacagcc atcaccaat                                                    19





<210>  1098

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1098

tcccacagcc atcaccaata                                                   20





<210>  1099

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1099

gtgcttccgt ctctgtgcca                                                   20





<210>  1100

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1100

cctcctcatc gtccactctc t                                                 21





<210>  1101

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1101

tcctcctcat cgtccactct c                                                 21





<210>  1102

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1102

cctcctcatc gtccactctc                                                   20





<210>  1103

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1103

tcctcctcat cgtccactct                                                   20





<210>  1104

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1104

atcctcctca tcgtccactc t                                                 21





<210>  1105

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1105

ctcctcatcg tccactctct                                                   20





<210>  1106

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1106

cctcctcatc gtccactct                                                    19





<210>  1107

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1107

ctcctcatcg tccactctct t                                                 21





<210>  1108

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1108

tcctcatcgt ccactctctt c                                                 21





<210>  1109

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1109

cctcatcgtc cactctcttc a                                                 21





<210>  1110

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1110

gccacctccc tcatagtcca                                                   20





<210>  1111

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1111

agccacctcc ctcatagtcc                                                   20





<210>  1112

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1112

agccacctcc ctcatagtcc a                                                 21





<210>  1113

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1113

gcagccacct ccctcatagt                                                   20





<210>  1114

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1114

cagccacctc cctcatagtc                                                   20





<210>  1115

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1115

agccacctcc ctcatagtc                                                    19





<210>  1116

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1116

cagccacctc cctcatagt                                                    19





<210>  1117

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1117

ctgctccacg attccttccc                                                   20





<210>  1118

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1118

ccacctccct catagtccag                                                   20





<210>  1119

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1119

ccacctccct catagtcca                                                    19





<210>  1120

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1120

cttcaccttc acctccgcca                                                   20





<210>  1121

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1121

cttcaccttc acctccgcca t                                                 21





<210>  1122

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1122

caccttcacc ttcacctcc                                                    19





<210>  1123

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1123

aggcatgttc cactctccc                                                    19





<210>  1124

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1124

gcaccttcac cttcacctcc                                                   20





<210>  1125

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1125

tgtttgtctt ctccctttc                                                    19





<210>  1126

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1126

tcaccttcac ctccgccatg                                                   20





<210>  1127

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1127

ttcaccttca cctccgccat                                                   20





<210>  1128

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1128

ttcaccttca cctccgcca                                                    19





<210>  1129

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1129

ttcaccttca cctccgccat g                                                 21





<210>  1130

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1130

gtcctgttgc tgtgtttccc                                                   20





<210>  1131

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1131

gtcctgttgc tgtgtttccc a                                                 21





<210>  1132

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1132

agtcctgttg ctgtgtttcc c                                                 21





<210>  1133

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1133

tcctgttgct gtgtttccc                                                    19





<210>  1134

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1134

tcctgttgct gtgtttccca                                                   20





<210>  1135

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1135

tcctttcatt tgctcccact                                                   20





<210>  1136

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1136

tcctttcatt tgctcccact t                                                 21





<210>  1137

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1137

ttcctttcat ttgctcccac t                                                 21





<210>  1138

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1138

cctttcattt gctcccactt                                                   20





<210>  1139

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1139

cctttcattt gctcccactt t                                                 21





<210>  1140

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1140

gtccctgtgc cctactcctt                                                   20





<210>  1141

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1141

tgtccctgtg ccctactcct                                                   20





<210>  1142

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1142

tgtccctgtg ccctactcct t                                                 21





<210>  1143

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1143

ttcctcctgt gccatctccc                                                   20





<210>  1144

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1144

atgtccctgt gccctactcc t                                                 21





<210>  1145

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1145

atgtccctgt gccctactcc                                                   20





<210>  1146

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1146

tttcctcctg tgccatctcc c                                                 21





<210>  1147

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1147

tccctgtgcc ctactccttg                                                   20





<210>  1148

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1148

tccctgtgcc ctactcctt                                                    19





<210>  1149

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1149

gatgtccctg tgccctactc                                                   20





<210>  1150

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1150

tcattccctc ctccagctcc t                                                 21





<210>  1151

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1151

cattccctcc tccagctcct                                                   20





<210>  1152

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1152

tcattccctc ctccagctcc                                                   20





<210>  1153

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1153

ccttccatcc tcctctttca                                                   20





<210>  1154

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1154

actctaccac ctttatctcc t                                                 21





<210>  1155

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1155

accttccatc ctcctctttc a                                                 21





<210>  1156

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1156

accttccatc ctcctctttc                                                   20





<210>  1157

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1157

attccctcct ccagctcctg                                                   20





<210>  1158

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1158

atcattccct cctccagctc c                                                 21





<210>  1159

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1159

attccctcct ccagctcct                                                    19





<210>  1160

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1160

acccacctct gcctcccaaa                                                   20





<210>  1161

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1161

tgatccaccc acctctgcct                                                   20





<210>  1162

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1162

accttcccac atctttcaca                                                   20





<210>  1163

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1163

ccttcccaca tctttcacat c                                                 21





<210>  1164

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1164

ccttcccaca tctttcaca                                                    19





<210>  1165

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1165

taccttccca catctttcac a                                                 21





<210>  1166

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1166

accttcccac atctttcac                                                    19





<210>  1167

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1167

taccttccca catctttcac                                                   20





<210>  1168

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1168

gccatcatcc tccttgtgtg                                                   20





<210>  1169

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1169

accttcccac atctttcaca t                                                 21





<210>  1170

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1170

tctccctctg ccatgtcctt                                                   20





<210>  1171

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1171

tctccctctg ccatgtcct                                                    19





<210>  1172

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1172

atctccctct gccatgtcct                                                   20





<210>  1173

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1173

tctccctctg ccatgtcctt t                                                 21





<210>  1174

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1174

aagccctccc acactctctg                                                   20





<210>  1175

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1175

atctccctct gccatgtcct t                                                 21





<210>  1176

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1176

aagccctccc acactctct                                                    19





<210>  1177

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1177

ctccctctgc catgtccttt                                                   20





<210>  1178

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1178

gggtctgtct ctcttctctc                                                   20





<210>  1179

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1179

ctccctctgc catgtcctt                                                    19





<210>  1180

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1180

acccacctca gcctcccaaa                                                   20





<210>  1181

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1181

ccacctcagc ctcccaaagt                                                   20





<210>  1182

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1182

tcctctcatc tcagcctcct                                                   20





<210>  1183

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1183

aatccaccca cctcagcctc                                                   20





<210>  1184

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1184

caatccaccc acctcagcct                                                   20





<210>  1185

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1185

atcctctcat ctcagcctcc t                                                 21





<210>  1186

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1186

cctctcatct cagcctcct                                                    19





<210>  1187

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1187

tcctctcatc tcagcctcc                                                    19





<210>  1188

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1188

atcctctcat ctcagcctcc                                                   20





<210>  1189

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1189

aatccaccca cctcagcct                                                    19





<210>  1190

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1190

cctctccagc accttctcct                                                   20





<210>  1191

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1191

accctctcca gcaccttctc                                                   20





<210>  1192

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1192

tcaccctctc cagcaccttc t                                                 21





<210>  1193

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1193

caccctctcc agcaccttct                                                   20





<210>  1194

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1194

tcaccctctc cagcaccttc                                                   20





<210>  1195

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1195

ttcaccctct ccagcacctt c                                                 21





<210>  1196

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1196

cattcaccct ctccagcacc                                                   20





<210>  1197

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1197

accctctcca gcaccttct                                                    19





<210>  1198

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1198

cattcaccct ctccagcacc t                                                 21





<210>  1199

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1199

ctctccagca ccttctcct                                                    19





<210>  1200

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1200

cttctccctc tgcttctctt                                                   20





<210>  1201

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1201

cttctccctc tgcttctct                                                    19





<210>  1202

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1202

cttctccctc tgcttctctt g                                                 21





<210>  1203

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1203

gcttctccct ctgcttctct                                                   20





<210>  1204

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1204

ccgcttctcc ctctgcttct                                                   20





<210>  1205

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1205

gcttctccct ctgcttctct t                                                 21





<210>  1206

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1206

cgcttctccc tctgcttctc t                                                 21





<210>  1207

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1207

ttctccctct gcttctcttg                                                   20





<210>  1208

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1208

gcttctccct ctgcttctc                                                    19





<210>  1209

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1209

tctccctctg cttctcttg                                                    19





<210>  1210

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1210

cctcctgtcc cactccatgt                                                   20





<210>  1211

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1211

ctcctgtccc actccatgt                                                    19





<210>  1212

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1212

actcagatcc caccgcagct                                                   20





<210>  1213

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1213

tactcagatc ccaccgcagc                                                   20





<210>  1214

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1214

tactcagatc ccaccgcagc t                                                 21





<210>  1215

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1215

atactcagat cccaccgcag c                                                 21





<210>  1216

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1216

atactcagat cccaccgcag                                                   20





<210>  1217

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1217

tactcagatc ccaccgcag                                                    19





<210>  1218

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1218

aggtcgctct tgttgcccac                                                   20





<210>  1219

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1219

tatactcaga tcccaccgca g                                                 21





<210>  1220

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1220

ctttgtccct gctgccacca                                                   20





<210>  1221

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1221

ttgtccctgc tgccaccatc                                                   20





<210>  1222

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1222

ctttgtccct gctgccacca t                                                 21





<210>  1223

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1223

tttgtccctg ctgccaccat c                                                 21





<210>  1224

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1224

tttgtccctg ctgccacca                                                    19





<210>  1225

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1225

tttgtccctg ctgccaccat                                                   20





<210>  1226

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1226

ttgtccctgc tgccaccat                                                    19





<210>  1227

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1227

cccttctgta ttcatcccac c                                                 21





<210>  1228

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1228

tgtccctgct gccaccatca                                                   20





<210>  1229

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1229

gaccttccct ctcttggca                                                    19





<210>  1230

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1230

tcccttactc cagcctcctc t                                                 21





<210>  1231

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1231

gtcctccctt actccagcct                                                   20





<210>  1232

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1232

ctcccttact ccagcctcct                                                   20





<210>  1233

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1233

tcccttactc cagcctcctc                                                   20





<210>  1234

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1234

tcctccctta ctccagcctc                                                   20





<210>  1235

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1235

gtctctgctg ctctctccct                                                   20





<210>  1236

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1236

gtctctgctg tccttccca                                                    19





<210>  1237

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1237

cgtctctgct gtccttccca                                                   20





<210>  1238

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1238

tcccttactc cagcctcct                                                    19





<210>  1239

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1239

tcctccctta ctccagcct                                                    19





<210>  1240

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1240

gtccacaccc atactctttc t                                                 21





<210>  1241

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1241

cccatactct ttctgtccct                                                   20





<210>  1242

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1242

acccatactc tttctgtccc t                                                 21





<210>  1243

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1243

cccatactct ttctgtccct t                                                 21





<210>  1244

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1244

cacccatact ctttctgtcc c                                                 21





<210>  1245

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1245

gtccacaccc atactctttc                                                   20





<210>  1246

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1246

tccacaccca tactctttct                                                   20





<210>  1247

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1247

acccatactc tttctgtccc                                                   20





<210>  1248

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1248

ctctctcttg tggtttcttc t                                                 21





<210>  1249

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1249

cccatactct ttctgtccc                                                    19





<210>  1250

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1250

ccctccttcc tcctcactct                                                   20





<210>  1251

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1251

cctccttcct cctcactctc                                                   20





<210>  1252

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1252

cctccttcct cctcactctc a                                                 21





<210>  1253

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1253

cctccttcct cctcactct                                                    19





<210>  1254

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1254

ctccttcctc ctcactctca                                                   20





<210>  1255

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1255

ctccttcctc ctcactctc                                                    19





<210>  1256

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1256

tctcttccct ttcttcctct                                                   20





<210>  1257

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1257

ctcttccctt tcttcctctt c                                                 21





<210>  1258

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1258

cttctcttcc ctttcttcct c                                                 21





<210>  1259

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1259

ctctcctttc cttctgccac t                                                 21





<210>  1260

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1260

gaccgtagtt cccacaccca                                                   20





<210>  1261

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1261

ccgtagttcc cacacccaat                                                   20





<210>  1262

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1262

gctccattct gacctccctg a                                                 21





<210>  1263

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1263

agaccgtagt tcccacaccc a                                                 21





<210>  1264

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1264

ccgtagttcc cacacccaa                                                    19





<210>  1265

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1265

ccgtagttcc cacacccaat g                                                 21





<210>  1266

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1266

gctccattct gacctccctg                                                   20





<210>  1267

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1267

agaccgtagt tcccacaccc                                                   20





<210>  1268

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1268

ctctcctacc gccatctttc c                                                 21





<210>  1269

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1269

gctccattct gacctccct                                                    19





<210>  1270

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1270

cctcctcctc ttctgcctct                                                   20





<210>  1271

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1271

ctcctcctct tctgcctctg                                                   20





<210>  1272

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1272

ctcctcctct tctgcctct                                                    19





<210>  1273

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1273

actcaccacc ctcagcatcg                                                   20





<210>  1274

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1274

actcaccacc ctcagcatc                                                    19





<210>  1275

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1275

gacatactca ccaccctcag c                                                 21





<210>  1276

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1276

tactcaccac cctcagcatc                                                   20





<210>  1277

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1277

tactcaccac cctcagcatc g                                                 21





<210>  1278

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1278

catactcacc accctcagca                                                   20





<210>  1279

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1279

acatactcac caccctcagc a                                                 21





<210>  1280

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1280

gccagtctct ccctttgtga                                                   20





<210>  1281

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1281

ttcgcctgtc ctgtgtccca                                                   20





<210>  1282

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1282

tgccagtctc tccctttgtg a                                                 21





<210>  1283

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1283

gccagtctct ccctttgtg                                                    19





<210>  1284

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1284

tgccagtctc tccctttgtg                                                   20





<210>  1285

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1285

ttgccagtct ctccctttgt                                                   20





<210>  1286

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1286

tgccagtctc tccctttgt                                                    19





<210>  1287

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1287

ttgccagtct ctccctttgt g                                                 21





<210>  1288

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1288

attgccagtc tctccctttg t                                                 21





<210>  1289

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1289

tcctcgtgcc tctgtctgtg t                                                 21





<210>  1290

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1290

tcagcccttc caagtccacc                                                   20





<210>  1291

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1291

tcagcccttc caagtccacc a                                                 21





<210>  1292

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1292

cagcccttcc aagtccacca                                                   20





<210>  1293

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1293

ttcagccctt ccaagtccac c                                                 21





<210>  1294

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1294

gttcagccct tccaagtcca c                                                 21





<210>  1295

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1295

agcccttcca agtccaccag                                                   20





<210>  1296

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1296

gctgcacatt gttcccaccc                                                   20





<210>  1297

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1297

gccactcccg aatcaactt                                                    19





<210>  1298

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1298

tgccactccc gaatcaactt                                                   20





<210>  1299

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1299

gccactcccg aatcaactta                                                   20





<210>  1300

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1300

ctccctttcc ttctccttca                                                   20





<210>  1301

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1301

gttccaccag actcccactt c                                                 21





<210>  1302

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1302

gctccctttc cttctccttc                                                   20





<210>  1303

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1303

ctccctttcc ttctccttc                                                    19





<210>  1304

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1304

gctccctttc cttctccttc a                                                 21





<210>  1305

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1305

gttccaccag actcccactt                                                   20





<210>  1306

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1306

gttccaccag actcccact                                                    19





<210>  1307

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1307

cctcatctct tcctccttcc t                                                 21





<210>  1308

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1308

tccctttcct tctccttca                                                    19





<210>  1309

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1309

gcctcatctc ttcctccttc c                                                 21





<210>  1310

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1310

ctcttacctc cctccctcct                                                   20





<210>  1311

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1311

ctcttacctc cctccctcct t                                                 21





<210>  1312

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1312

ttacctccct ccctccttcc                                                   20





<210>  1313

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1313

tcttacctcc ctccctcctt c                                                 21





<210>  1314

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1314

cttacctccc tccctccttc                                                   20





<210>  1315

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1315

tcttacctcc ctccctcctt                                                   20





<210>  1316

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1316

tcttacctcc ctccctcct                                                    19





<210>  1317

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1317

gccctccctc tgacttcctt                                                   20





<210>  1318

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1318

cttacctccc tccctcctt                                                    19





<210>  1319

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1319

ccttctacca ccttcccagc                                                   20





<210>  1320

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1320

cttcctcttc tgccatctcc c                                                 21





<210>  1321

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1321

gtgctcttcc cttcctgact c                                                 21





<210>  1322

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1322

tcctcttctg ccatctccca                                                   20





<210>  1323

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1323

cctcttcctc tcctcttcct c                                                 21





<210>  1324

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1324

ttcctcttct gccatctccc                                                   20





<210>  1325

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1325

tctcgtcctc cacatccctg                                                   20





<210>  1326

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1326

ttcctcttct gccatctccc a                                                 21





<210>  1327

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1327

tcctcttctg ccatctccc                                                    19





<210>  1328

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1328

cctcttcctc tcctcttcct                                                   20





<210>  1329

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1329

atctcgtcct ccacatccct                                                   20





<210>  1330

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1330

tttccaacct caccatccct                                                   20





<210>  1331

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1331

ttccaacctc accatccct                                                    19





<210>  1332

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1332

gactccactg cctgcctctt                                                   20





<210>  1333

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1333

ttccaacctc accatcccta                                                   20





<210>  1334

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1334

tttccaacct caccatccct a                                                 21





<210>  1335

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1335

gactccactg cctgcctctt t                                                 21





<210>  1336

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1336

tccaacctca ccatcccta                                                    19





<210>  1337

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1337

tttccaacct caccatccc                                                    19





<210>  1338

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1338

actccactgc ctgcctcttt                                                   20





<210>  1339

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1339

agactccact gcctgcctct                                                   20





<210>  1340

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1340

ggttagtctc tgtggtgtgc t                                                 21





<210>  1341

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1341

tcctcctcat catcttcctc a                                                 21





<210>  1342

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1342

tcctcctcat catcttcctc                                                   20





<210>  1343

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1343

ggttagtctc tgtggtgtgc                                                   20





<210>  1344

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1344

cctcctcatc atcttcctca                                                   20





<210>  1345

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1345

atcctcctca tcatcttcct c                                                 21





<210>  1346

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1346

tggttagtct ctgtggtgtg c                                                 21





<210>  1347

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1347

cctctgcttc tctatctcca                                                   20





<210>  1348

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1348

tccgttctat ccgcctctgc                                                   20





<210>  1349

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1349

gttagtctct gtggtgtgct                                                   20





<210>  1350

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1350

gcctctccct gatttctccc                                                   20





<210>  1351

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1351

ctccttctct ctttcccttt c                                                 21





<210>  1352

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1352

tccttctctc tttccctttc t                                                 21





<210>  1353

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1353

gcctctccct gatttctccc a                                                 21





<210>  1354

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1354

ccttctctct ttccctttct                                                   20





<210>  1355

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1355

ctccttctct ctttcccttt                                                   20





<210>  1356

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1356

tccttctctc tttccctttc                                                   20





<210>  1357

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1357

ccttctctct ttccctttct t                                                 21





<210>  1358

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1358

ctccttctct ctttccctt                                                    19





<210>  1359

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1359

gctccttctc tctttccctt                                                   20





<210>  1360

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1360

tcccttcttg tttctccctc                                                   20





<210>  1361

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1361

ttcccttctt gtttctccct c                                                 21





<210>  1362

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1362

gttcccttgc cagtctcacc                                                   20





<210>  1363

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1363

cccttcttgt ttctccctc                                                    19





<210>  1364

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1364

ttcccttctt gtttctccct                                                   20





<210>  1365

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1365

cccttcttgt ttctccctcg c                                                 21





<210>  1366

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1366

tcccttcttg tttctccct                                                    19





<210>  1367

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1367

gtgtcctctt tcccatgctt c                                                 21





<210>  1368

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1368

gtcctctttc ccatgcttct                                                   20





<210>  1369

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1369

ggttcccttg ccagtctcac                                                   20





<210>  1370

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1370

gctctgtgta ttctctcccg                                                   20





<210>  1371

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1371

gctctgtgta ttctctccc                                                    19





<210>  1372

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1372

ctctgtgtat tctctcccg                                                    19





<210>  1373

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1373

ggctctgtgt attctctccc                                                   20





<210>  1374

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1374

ggctctgtgt attctctccc g                                                 21





<210>  1375

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1375

tggctctgtg tattctctcc c                                                 21





<210>  1376

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1376

gctctgtgta ttctctcccg g                                                 21





<210>  1377

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1377

aggaccactc tgctgtttgt                                                   20





<210>  1378

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1378

ctctgctgtt tgtgttgtcg t                                                 21





<210>  1379

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1379

ggaccactct gctgtttgt                                                    19





<210>  1380

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1380

gttctgggct tcgtgaggtt                                                   20





<210>  1381

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1381

gttctgggct tcgtgaggtt t                                                 21





<210>  1382

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1382

gccttcttcc tgtagttctg g                                                 21





<210>  1383

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1383

gttctgggct tcgtgaggt                                                    19





<210>  1384

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1384

tcctgtagtt ctgggcttcg t                                                 21





<210>  1385

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1385

cacccacaat gccttcttcc t                                                 21





<210>  1386

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1386

agttctgggc ttcgtgaggt                                                   20





<210>  1387

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1387

cttcctgtag ttctgggctt c                                                 21





<210>  1388

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1388

cttcttcctg tagttctggg c                                                 21





<210>  1389

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1389

cctgtagttc tgggcttcgt                                                   20





<210>  1390

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1390

gtcattctcc ttccctctca                                                   20





<210>  1391

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1391

gtcattctcc ttccctctc                                                    19





<210>  1392

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1392

gactctctcc gccaccacaa                                                   20





<210>  1393

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1393

gtcattctcc ttccctctca g                                                 21





<210>  1394

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1394

actcccttcg ccatgccttc                                                   20





<210>  1395

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1395

actctctccg ccaccacaa                                                    19





<210>  1396

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1396

gccatgctgt tctctcccag                                                   20





<210>  1397

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1397

tactcccttc gccatgcctt c                                                 21





<210>  1398

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1398

gccatgctgt tctctccca                                                    19





<210>  1399

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1399

tcattctcct tccctctca                                                    19





<210>  1400

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1400

gtctccaatg tcagcactcc c                                                 21





<210>  1401

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1401

accgcttctg tcacctccca                                                   20





<210>  1402

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1402

tctccaatgt cagcactccc t                                                 21





<210>  1403

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1403

tcccagagca cttcagccac a                                                 21





<210>  1404

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1404

tcccagagca cttcagccac                                                   20





<210>  1405

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1405

ctccaatgtc agcactccct                                                   20





<210>  1406

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1406

tctccaatgt cagcactccc                                                   20





<210>  1407

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1407

gctcccacgg ttgtttcctt                                                   20





<210>  1408

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1408

gctcccacgg ttgtttcct                                                    19





<210>  1409

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1409

gctcccacgg ttgtttcctt t                                                 21





<210>  1410

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1410

gtcccacgcc caagtcagta                                                   20





<210>  1411

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1411

gtcccacgcc caagtcagta t                                                 21





<210>  1412

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1412

tcccacgccc aagtcagtat                                                   20





<210>  1413

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1413

tcccacgccc aagtcagta                                                    19





<210>  1414

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1414

tcccacgccc aagtcagtat t                                                 21





<210>  1415

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1415

gacccacagc cttccaacca                                                   20





<210>  1416

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1416

acccacagcc ttccaaccag                                                   20





<210>  1417

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1417

acccacagcc ttccaacca                                                    19





<210>  1418

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1418

tccctgcttg cttcttgcgg t                                                 21





<210>  1419

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1419

agggactctg tgggcttca                                                    19





<210>  1420

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1420

cctcccactt ctccttctcc t                                                 21





<210>  1421

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1421

tcctcccact tctccttctc c                                                 21





<210>  1422

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1422

cctcccactt ctccttctcc                                                   20





<210>  1423

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1423

ctcctcccac ttctccttct c                                                 21





<210>  1424

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1424

tctcctccca cttctccttc t                                                 21





<210>  1425

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1425

ctcccacttc tccttctcct                                                   20





<210>  1426

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1426

ctcctcccac ttctccttct                                                   20





<210>  1427

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1427

cttctcctcc cacttctcct                                                   20





<210>  1428

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1428

tcctcccact tctccttctc                                                   20





<210>  1429

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1429

tctcctccca cttctccttc                                                   20





<210>  1430

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1430

ccactctgct ccttctccca                                                   20





<210>  1431

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1431

actctgctcc ttctcccacc                                                   20





<210>  1432

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1432

actctgctcc ttctcccacc a                                                 21





<210>  1433

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1433

cactctgctc cttctcccac                                                   20





<210>  1434

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1434

ctctgctcct tctcccacca                                                   20





<210>  1435

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1435

actctgctcc ttctcccac                                                    19





<210>  1436

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1436

aagccaccca cctgatccct                                                   20





<210>  1437

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1437

tctgctcctt ctcccacca                                                    19





<210>  1438

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1438

actcctctca caccctcca                                                    19





<210>  1439

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1439

cactctgctc cttctccca                                                    19





<210>  1440

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1440

tctccttcac actgctccca c                                                 21





<210>  1441

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1441

accttctctc ccttctttg                                                    19





<210>  1442

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1442

accttctctc ccttctttgc                                                   20





<210>  1443

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1443

ctccttcaca ctgctcccac                                                   20





<210>  1444

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1444

ccttctctcc cttctttgc                                                    19





<210>  1445

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1445

gtcgttcttg cctcttctcc t                                                 21





<210>  1446

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1446

taccttctct cccttctttg                                                   20





<210>  1447

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1447

taccttctct cccttctttg c                                                 21





<210>  1448

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1448

gtcgttcttg cctcttctcc                                                   20





<210>  1449

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1449

taccttctct cccttcttt                                                    19





<210>  1450

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1450

gccacttcct catagtccct c                                                 21





<210>  1451

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1451

gccacttcct catagtccct                                                   20





<210>  1452

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1452

cgccacttcc tcatagtccc t                                                 21





<210>  1453

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1453

cttcctcata gtccctctcc a                                                 21





<210>  1454

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1454

cgccacttcc tcatagtccc                                                   20





<210>  1455

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1455

gccacttcct catagtccc                                                    19





<210>  1456

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1456

tcctcatagt ccctctccag                                                   20





<210>  1457

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1457

ccacttcctc atagtccctc t                                                 21





<210>  1458

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1458

tgtggtggag tgggtggtga                                                   20





<210>  1459

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1459

tgccaccctc tcctctcctt                                                   20





<210>  1460

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1460

ttgccaccct ctcctctcct                                                   20





<210>  1461

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1461

ttgccaccct ctcctctcct t                                                 21





<210>  1462

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1462

ccctctcctc tccttcctca                                                   20





<210>  1463

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1463

attgccaccc tctcctctcc t                                                 21





<210>  1464

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1464

accctctcct ctccttcctc                                                   20





<210>  1465

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1465

attgccaccc tctcctctcc                                                   20





<210>  1466

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1466

accctctcct ctccttcctc a                                                 21





<210>  1467

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1467

caccctctcc tctccttcct                                                   20





<210>  1468

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1468

tcattgccac cctctcctct c                                                 21





<210>  1469

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1469

gacactccca cccttaccag                                                   20





<210>  1470

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1470

acactcccac ccttaccag                                                    19





<210>  1471

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1471

gacactccca cccttacca                                                    19





<210>  1472

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1472

agacactccc acccttacca g                                                 21





<210>  1473

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1473

agacactccc acccttacca                                                   20





<210>  1474

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1474

agacactccc acccttacc                                                    19





<210>  1475

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1475

gtctcctcta cctccttgct                                                   20





<210>  1476

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1476

gtctcctcta cctccttgct a                                                 21





<210>  1477

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1477

gtctcctcta cctccttgc                                                    19





<210>  1478

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1478

cacctgtccc acttccttt                                                    19





<210>  1479

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1479

agtcatctcc ctcgccacca                                                   20





<210>  1480

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1480

gtcatctccc tcgccaccaa                                                   20





<210>  1481

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1481

cccatgccac tcccagacaa                                                   20





<210>  1482

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1482

agtcatctcc ctcgccacca a                                                 21





<210>  1483

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1483

tcatctccct cgccaccaa                                                    19





<210>  1484

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1484

ccatgccact cccagacaag                                                   20





<210>  1485

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1485

tctcccagca tttccatcca c                                                 21





<210>  1486

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1486

ccatgccact cccagacaa                                                    19





<210>  1487

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1487

gtctcccatt ctcccagca                                                    19





<210>  1488

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1488

ctcccagcat ttccatccac                                                   20





<210>  1489

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1489

tcaccctcag ccactcccaa                                                   20





<210>  1490

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1490

tcccgcactc actctccact                                                   20





<210>  1491

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1491

tcaccctcag ccactcccaa a                                                 21





<210>  1492

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1492

cctcctgttc ttcctcttcc t                                                 21





<210>  1493

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1493

tcctcctgtt cttcctcttc c                                                 21





<210>  1494

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1494

caccctcagc cactcccaaa                                                   20





<210>  1495

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1495

cctcctgttc ttcctcttcc                                                   20





<210>  1496

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1496

aactcaccct cagccactcc                                                   20





<210>  1497

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1497

accctcagcc actcccaaa                                                    19





<210>  1498

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1498

ccgcactcac tctccactca                                                   20





<210>  1499

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1499

tcttcccacc tcagcctctc                                                   20





<210>  1500

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1500

tcttcccacc tcagcctctc a                                                 21





<210>  1501

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1501

cttcccacct cagcctctca                                                   20





<210>  1502

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1502

atcttcccac ctcagcctct c                                                 21





<210>  1503

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1503

tcttcccacc tcagcctct                                                    19





<210>  1504

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1504

atcttcccac ctcagcctct                                                   20





<210>  1505

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1505

ttcccacctc agcctctca                                                    19





<210>  1506

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1506

cttcccacct cagcctctca a                                                 21





<210>  1507

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1507

tcctccatca ttccgccacc                                                   20





<210>  1508

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1508

ttcccacctc agcctctcaa                                                   20





<210>  1509

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1509

cccatccttc tctcacctcc t                                                 21





<210>  1510

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1510

cccatccttc tctcacctcc                                                   20





<210>  1511

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1511

acccatcctt ctctcacctc c                                                 21





<210>  1512

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1512

ccatccttct ctcacctcct                                                   20





<210>  1513

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1513

acccatcctt ctctcacctc                                                   20





<210>  1514

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1514

tgggttgggt tggaggtggt                                                   20





<210>  1515

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1515

ttgggttggg ttggaggtgg t                                                 21





<210>  1516

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1516

ccatccttct ctcacctcc                                                    19





<210>  1517

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1517

cccatccttc tctcacctc                                                    19





<210>  1518

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1518

ccatccttct ctcacctcct g                                                 21





<210>  1519

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1519

ctcgctccca cccatcactt                                                   20





<210>  1520

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1520

tcgctcccac ccatcacttc                                                   20





<210>  1521

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1521

gctcccaccc atcacttcgt                                                   20





<210>  1522

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1522

gttctagttc ctgcccatcc c                                                 21





<210>  1523

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1523

tcgctcccac ccatcactt                                                    19





<210>  1524

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1524

atcctttccc gtctctctgc                                                   20





<210>  1525

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1525

tcctttcccg tctctctgc                                                    19





<210>  1526

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1526

tctagttcct gcccatccct                                                   20





<210>  1527

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1527

tcctttcccg tctctctgcg                                                   20





<210>  1528

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1528

ccaatccttt cccgtctctc t                                                 21





<210>  1529

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1529

cctcttcacc tccctctcct                                                   20





<210>  1530

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1530

ctcttcacct ccctctcct                                                    19





<210>  1531

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1531

ttccgcctct tcacctccct                                                   20





<210>  1532

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1532

ctcttcacct ccctctcctg                                                   20





<210>  1533

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1533

tcttcacctc cctctcctg                                                    19





<210>  1534

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1534

tccatctgac tcccttcctc                                                   20





<210>  1535

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1535

tcttcacctc cctctcctgg                                                   20





<210>  1536

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1536

ccatctgact cccttcctc                                                    19





<210>  1537

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1537

tccatctgac tcccttcct                                                    19





<210>  1538

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic Construct



<400>  1538

acttccgcct cttcacctcc                                                   20





<210>  1539

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1539

uggcaucaua ggcgaguauu a                                                 21





<210>  1540

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1540

ccgggaugcu auugaguuaa a                                                 21





<210>  1541

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1541

cccguggucc agaucauuua u                                                 21





<210>  1542

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1542

uagccgaagu uugguucagu a                                                 21





<210>  1543

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1543

cuggauggac uucguguaga u                                                 21





<210>  1544

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1544

accguagaga uggccagucu a                                                 21





<210>  1545

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1545

ccagacugug cugaaacgga a                                                 21





<210>  1546

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1546

aagcggccgu guugcaaucu a                                                 21





<210>  1547

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1547

cacgcuuggu cccgaggcca a                                                 21





<210>  1548

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1548

caccaugagc gacguggcua u                                                 21





<210>  1549

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1549

aaucacacca ccugaccaag a                                                 21





<210>  1550

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1550

aaccaggacc augagaagcu u                                                 21





<210>  1551

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1551

cugcagauau auguggagua a                                                 21





<210>  1552

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1552

cugcggaaug aaaguuucua u                                                 21





<210>  1553

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1553

uagauucugg ugccgauaua a                                                 21





<210>  1554

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1554

ugcgaaugca guuaauaagu a                                                 21





<210>  1555

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1555

cagaauaacg auugugacca u                                                 21





<210>  1556

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1556

ccgcuucaag caguucguca a                                                 21





<210>  1557

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1557

cccaggcuca auacagugua a                                                 21





<210>  1558

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1558

cucgcccaug gcuccacgua a                                                 21





<210>  1559

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1559

cucccaggag cuaacguaua a                                                 21





<210>  1560

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1560

gagcguugua ccggcacuuu a                                                 21





<210>  1561

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1561

caagucgucg uucgccuucu a                                                 21





<210>  1562

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1562

ccguuggacc ucacuggcaa a                                                 21





<210>  1563

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1563

ugccaucgug uggaagauca a                                                 21





<210>  1564

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1564

acgugugacu ucguccaguu a                                                 21





<210>  1565

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1565

uggaggcuua uucaucuaua a                                                 21





<210>  1566

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1566

uuggaggcuu auucaucuau a                                                 21





<210>  1567

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1567

acguggaaac cguggaguac a                                                 21





<210>  1568

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1568

cacgauccuc uacaagcuua a                                                 21





<210>  1569

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1569

agggaagacc acgauccucu a                                                 21





<210>  1570

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1570

caccauaggc uucaacgugg a                                                 21





<210>  1571

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1571

ccgauugacu uuggagaagg a                                                 21





<210>  1572

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1572

accgagaguc accaacagau a                                                 21





<210>  1573

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1573

cugcaucgcc acuauaucca a                                                 21





<210>  1574

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1574

uuccagagca uugaauuacu a                                                 21





<210>  1575

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1575

ccgaaaccuc cgggagaaua a                                                 21





<210>  1576

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1576

cagguucagu guguuaggac a                                                 21





<210>  1577

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1577

cugggaccua uauguauauu u                                                 21





<210>  1578

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1578

cagccacggc ucggagaaga a                                                 21





<210>  1579

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1579

ccuggugauc cugagaauua a                                                 21





<210>  1580

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1580

caguggguga aagcucauga a                                                 21





<210>  1581

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1581

uccgccaucc agcaugacaa a                                                 21





<210>  1582

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1582

cccaaugcuc uuuaacuacg a                                                 21





<210>  1583

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1583

aacuguuaaa uugaacguaa a                                                 21





<210>  1584

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1584

cugguuaaua caaaucugcg a                                                 21





<210>  1585

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1585

ucaggcguuc uccgaagaga a                                                 21





<210>  1586

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1586

aaccucuagu aucccugcua a                                                 21





<210>  1587

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1587

cacgagcccu ugcagaauga a                                                 21





<210>  1588

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1588

caagaauuac ccacuucgua a                                                 21





<210>  1589

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1589

ccgccacggg cgcauccuua a                                                 21





<210>  1590

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1590

cccguucugg uuggaaguac u                                                 21





<210>  1591

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1591

cagagaaugc uuauaacgca a                                                 21





<210>  1592

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1592

cagucgauug uacaacuuua a                                                 21





<210>  1593

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1593

accggaguua gaagaaacca u                                                 21





<210>  1594

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1594

ugggacuaug uacauacguu a                                                 21





<210>  1595

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1595

cuguugacgc uucacaagua a                                                 21





<210>  1596

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1596

gaccgauuag uuauagaaau a                                                 21





<210>  1597

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1597

cuggcguaag uugccagagc a                                                 21





<210>  1598

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1598

cccaaguacc uccucagguu a                                                 21





<210>  1599

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1599

cuccagauau augcucucga a                                                 21





<210>  1600

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1600

uuggaccaua uacaaacaac a                                                 21





<210>  1601

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1601

agaguagagu gugcaauaca a                                                 21





<210>  1602

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1602

ugggcugacu uuauugaccc a                                                 21





<210>  1603

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1603

agggacuucg cuggaaagaa a                                                 21





<210>  1604

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1604

aaugagcuua uuuaagcuca a                                                 21





<210>  1605

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1605

cgccgccucu uugagugcua a                                                 21





<210>  1606

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1606

uaggaaaugc ugacucguuc a                                                 21





<210>  1607

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1607

cagauguaua guauucagua u                                                 21





<210>  1608

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1608

caggcaggcu uuggaguugu u                                                 21





<210>  1609

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1609

cugcuggaug ucaagacgug a                                                 21





<210>  1610

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1610

cagcgacucc auggugggcu a                                                 21





<210>  1611

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1611

gaggcuggug uggacuaucu a                                                 21





<210>  1612

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1612

aagcacccag cuuguaacuu a                                                 21





<210>  1613

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1613

cuccucaagg cuauagggau a                                                 21





<210>  1614

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1614

caccggagcu gcucagaguu a                                                 21





<210>  1615

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1615

caccgucugg aucgaguacu a                                                 21





<210>  1616

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1616

ccgcgugacc cucuucugca u                                                 21





<210>  1617

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1617

cugacugugg cuugaaauaa a                                                 21





<210>  1618

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1618

cagcugggug uuccguguaa a                                                 21





<210>  1619

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1619

aagggugguc caacugccaa a                                                 21





<210>  1620

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1620

accgcucagg aggcugcuau a                                                 21





<210>  1621

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1621

aagguuauuu ccagcgauga u                                                 21





<210>  1622

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1622

caaggucauu augucacugc a                                                 21





<210>  1623

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1623

gacaagcaac uuagcacaua a                                                 21





<210>  1624

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1624

acccagacaa uagacuauca a                                                 21





<210>  1625

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1625

aggcuuugaa cuaacaauug a                                                 21





<210>  1626

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1626

uuggaacaug ucaucaaggu a                                                 21





<210>  1627

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1627

acccaugugc augaguacaa a                                                 21





<210>  1628

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1628

ccgguucacc uccgaugcca a                                                 21





<210>  1629

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1629

ccgagcggac cgcgacaaga a                                                 21





<210>  1630

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1630

cucguccgcg aagaugacaa a                                                 21





<210>  1631

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1631

cgacauaacu auguucggaa a                                                 21





<210>  1632

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1632

uuggcguuga agauacacua a                                                 21





<210>  1633

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1633

uugcccguuu aagaauggaa a                                                 21





<210>  1634

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1634

cuccaacgug aaauucauuc a                                                 21





<210>  1635

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1635

cuggauccua cauccaagca a                                                 21





<210>  1636

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1636

gagacgcaua cugacgccaa a                                                 21





<210>  1637

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1637

aaggagcuca cauuuaugga a                                                 21





<210>  1638

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1638

cuccggcacu uugccugcga a                                                 21





<210>  1639

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1639

uagggcggaa guaccaguca a                                                 21





<210>  1640

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1640

caccguccuu accaugaaga a                                                 21





<210>  1641

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1641

cugcauagcc gugcuucucu a                                                 21





<210>  1642

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1642

aacguguuug augaggccgu a                                                 21





<210>  1643

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1643

caccguaucg ucaaacagug a                                                 21





<210>  1644

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1644

aagccuauca gaaugaauua a                                                 21





<210>  1645

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1645

cugugcuaau cuggcccuca a                                                 21





<210>  1646

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1646

cugcucgucu guuacgccaa a                                                 21





<210>  1647

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1647

cucgagggag cuguucuaug a                                                 21





<210>  1648

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1648

uucguaccgg auggagacca a                                                 21





<210>  1649

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1649

gcgagucauu ugacugugca a                                                 21





<210>  1650

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1650

acgcaaguac auccagacag a                                                 21





<210>  1651

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1651

uaccguaagg auggucagua u                                                 21





<210>  1652

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1652

caagaucugg gagaucacaa a                                                 21





<210>  1653

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1653

cacgauaauc acuaguguug a                                                 21





<210>  1654

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1654

cagaagaugc ucaguaagac a                                                 21





<210>  1655

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1655

ccggagcucg ucccgcucca a                                                 21





<210>  1656

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1656

agagcgaaua cuggaagaga a                                                 21





<210>  1657

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1657

aagaacgaca acgucaacaa a                                                 21





<210>  1658

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1658

cgcgugcgga agcguuccaa a                                                 21





<210>  1659

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1659

aacauugugg cugauaacag a                                                 21





<210>  1660

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1660

caccacggca cucaccauau u                                                 21





<210>  1661

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1661

aaccacuuau aagcagguuu a                                                 21





<210>  1662

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1662

guccgucuuc ccggaaguca a                                                 21





<210>  1663

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1663

accaucgaug accgaaagug a                                                 21





<210>  1664

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1664

aagguucacu augcuaggcc a                                                 21





<210>  1665

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1665

caagcucgcc uucuacccua a                                                 21





<210>  1666

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1666

auggaugaaa uaacucacga u                                                 21





<210>  1667

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1667

cugggaggaa uugguauauu a                                                 21





<210>  1668

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1668

cucgagaaga cagcuggcua a                                                 21





<210>  1669

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1669

agcccucaca gaagucauga a                                                 21





<210>  1670

<211>  20

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1670

aagauccgga ccuaauauau                                                   20





<210>  1671

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1671

cuccauuuga gaaaccuaau a                                                 21





<210>  1672

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1672

ccgcggcauc aucgaguucc a                                                 21





<210>  1673

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1673

gacgauguuc gagcucucaa a                                                 21





<210>  1674

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1674

ccgcuacuac gugacccgga a                                                 21





<210>  1675

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1675

aagggacaug uuacccgaug a                                                 21





<210>  1676

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1676

uuagaguaug uccguaucau a                                                 21





<210>  1677

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1677

cuccucuagg uggcccauuu a                                                 21





<210>  1678

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1678

ugcggucaua aaugacuuca a                                                 21





<210>  1679

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1679

aaagggugua uugacaacag a                                                 21





<210>  1680

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1680

caagaucuaa ucaguuguac a                                                 21





<210>  1681

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1681

caggaagccg uucuugacaa a                                                 21





<210>  1682

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1682

cagcgccuca ucaagaaagu a                                                 21





<210>  1683

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1683

cacucggaag ugugagcuuu a                                                 21





<210>  1684

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1684

cugguuguuu gcaguagauu a                                                 21





<210>  1685

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1685

gaggaacuug agaucucuuu a                                                 21





<210>  1686

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1686

uagccuuagg uauuccuaga a                                                 21





<210>  1687

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1687

uacgagcagc ugaacaggaa a                                                 21





<210>  1688

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1688

ccggaacgag cccaaguaca a                                                 21





<210>  1689

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1689

gcacgucuuu ccagaauuca a                                                 21





<210>  1690

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1690

aaggaccugc ugaagagaca a                                                 21





<210>  1691

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1691

auggaguauc ggcuaaguca a                                                 21





<210>  1692

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1692

ugcacgggag ucauaacacu a                                                 21





<210>  1693

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1693

uucguuuggc uuguauguug a                                                 21





<210>  1694

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1694

gaggcucaug ucgagguuua a                                                 21





<210>  1695

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1695

cagcgucauu ucggccucuu a                                                 21





<210>  1696

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1696

auggcguuug aagaaccuau a                                                 21





<210>  1697

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1697

cagaccgaug ccggcggaga a                                                 21





<210>  1698

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1698

acgauggcgc aucuaguucu a                                                 21





<210>  1699

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1699

aucccggcag gcgauaaacu a                                                 21





<210>  1700

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1700

accagccuag gaauucgguu a                                                 21





<210>  1701

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1701

aggagaguuu ggaauccgga a                                                 21





<210>  1702

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1702

uacguggaau uggaucuaca u                                                 21





<210>  1703

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1703

aaacgugguc cuugcaacaa a                                                 21





<210>  1704

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1704

cccagccucc ucacucauag a                                                 21





<210>  1705

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1705

ccaguugagc uuggaccgag a                                                 21





<210>  1706

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1706

cacgacugug guugagauca u                                                 21





<210>  1707

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1707

cuccucuagu ucagagacau a                                                 21





<210>  1708

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1708

uucggaaaug ccucacauau a                                                 21





<210>  1709

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1709

ucgcuuggag gcugccacua a                                                 21





<210>  1710

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1710

cugcagaggg aguacagcaa a                                                 21





<210>  1711

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1711

accaguagac uugaagcuaa a                                                 21





<210>  1712

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1712

cagcacggau cuaaaccagg a                                                 21





<210>  1713

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1713

cagcgucauc uuugguugau a                                                 21





<210>  1714

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1714

auggauggac uguauaccgu a                                                 21





<210>  1715

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1715

aagagggaua ugaacgcuca u                                                 21





<210>  1716

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1716

gugggccagg aaauuguaau a                                                 21





<210>  1717

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1717

caccggaggc auaauccuaa a                                                 21





<210>  1718

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1718

accggugucg uaacugcauu a                                                 21





<210>  1719

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1719

cuccugcagc accgacuuca a                                                 21





<210>  1720

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1720

caccagcggg cugauccuga a                                                 21





<210>  1721

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1721

ccggucuaac gucucacacc a                                                 21





<210>  1722

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1722

aagcccuuuc aagaagcgcu a                                                 21





<210>  1723

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1723

acugcuaggc auaauuauca a                                                 21





<210>  1724

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1724

auggcaguaa ccaugagguu a                                                 21





<210>  1725

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1725

cagagugucg cugguaaaua a                                                 21





<210>  1726

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1726

uacgaggugu aagagcuaua a                                                 21





<210>  1727

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1727

ccgguacugc guggacggaa a                                                 21





<210>  1728

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1728

cugguagauc cugcuaccuc a                                                 21





<210>  1729

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1729

cacagauuau ccacccguca a                                                 21





<210>  1730

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1730

cuggaagaac cgcaucuaua a                                                 21





<210>  1731

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1731

aacuaccaga uugucaauca u                                                 21





<210>  1732

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1732

uggaggcgga uuaguaauau u                                                 21





<210>  1733

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1733

aaacguagug acuuucagga a                                                 21





<210>  1734

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1734

caagguuuag acaguccaug a                                                 21





<210>  1735

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1735

caggaacauu cccacauaau a                                                 21





<210>  1736

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1736

cccggcugac caacauucaa a                                                 21





<210>  1737

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1737

cccacauaau acauuccauc a                                                 21





<210>  1738

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1738

cacaguccac gagaagcuca a                                                 21





<210>  1739

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1739

uggccuuuag cuuuauguau a                                                 21





<210>  1740

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1740

cgcgaggagg agaaacucaa a                                                 21





<210>  1741

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1741

ccgcaacagc auggucauuc a                                                 21





<210>  1742

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1742

ccucagguuc uugaccauga a                                                 21





<210>  1743

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1743

cugguaaaug gacuuccuua a                                                 21





<210>  1744

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1744

acccgaagug cugccaugaa a                                                 21





<210>  1745

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1745

cccgacaaga auacaacgau a                                                 21





<210>  1746

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1746

cagcacagaa auaucgacca a                                                 21





<210>  1747

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1747

aagguuguuu cuaaacgucc a                                                 21





<210>  1748

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1748

aucgacguuu agaucccaua a                                                 21





<210>  1749

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1749

cagcuucgcg gagcugcuua a                                                 21





<210>  1750

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1750

aagauggccc uuguacuaua a                                                 21





<210>  1751

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1751

caggccgacc uguaugacga a                                                 21





<210>  1752

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1752

aagggccuug auuaggacca a                                                 21





<210>  1753

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1753

aaacgaagau auuaacaucu a                                                 21





<210>  1754

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1754

aucauggauc acaccaacga a                                                 21





<210>  1755

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1755

cacacaguaa ugaaauacua a                                                 21





<210>  1756

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1756

cuggacuuac ugcaucagua a                                                 21





<210>  1757

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1757

ugggagugga augaauuaau u                                                 21





<210>  1758

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1758

gucgaucuug gcacucacua a                                                 21





<210>  1759

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1759

cccuauggac cagucaaaua a                                                 21





<210>  1760

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1760

ccgcgacuau gugaugcgca u                                                 21





<210>  1761

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1761

gccaaccuuc ccgccagacu a                                                 21





<210>  1762

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1762

ccaccucauc cggcugcuca a                                                 21





<210>  1763

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1763

cccguggaau gaaauccgaa a                                                 21





<210>  1764

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1764

caccgugagg aucgucacca u                                                 21





<210>  1765

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1765

ccgggucgcg ccugcaccga a                                                 21





<210>  1766

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1766

cccagagcuc gugacgagca a                                                 21





<210>  1767

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1767

guggagcuug uugaauuuau a                                                 21





<210>  1768

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1768

uuggcuugua uuccggucca a                                                 21





<210>  1769

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1769

uugcgaucug auacagcaca a                                                 21





<210>  1770

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1770

auguucgagu uucaaauaac a                                                 21





<210>  1771

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1771

aagaacaauc uaucauucca a                                                 21





<210>  1772

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1772

caguaucugu uacacauuag a                                                 21





<210>  1773

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1773

ugcaauuggg ucacaguguu a                                                 21





<210>  1774

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1774

uugcuauaag acaguaauau a                                                 21





<210>  1775

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1775

cagguacuug aagcaauuuc a                                                 21





<210>  1776

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1776

auggaguuaa cgggugaaua a                                                 21





<210>  1777

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1777

uugcgagaau gaggaggaca a                                                 21





<210>  1778

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1778

cugggcugcg accaauggaa a                                                 21





<210>  1779

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1779

uucgcuuuau gacucaccuu a                                                 21





<210>  1780

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1780

agggauucac uuguucgaca a                                                 21





<210>  1781

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1781

uccgcuuguc acugaauugg a                                                 21





<210>  1782

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1782

uagauacgag agagcaauuu a                                                 21





<210>  1783

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1783

aacuauagcc caggaagaua a                                                 21





<210>  1784

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1784

cggaucagcu uggaagcuua a                                                 21





<210>  1785

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1785

cugccuaucu guauaacgaa a                                                 21





<210>  1786

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1786

ccgaacggua auaauacgcc a                                                 21





<210>  1787

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1787

caccauuaug ugcgcugaua a                                                 21





<210>  1788

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1788

cacggugaau ggcuuuguau a                                                 21





<210>  1789

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1789

aagacagucu aaacuacgaa a                                                 21





<210>  1790

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1790

aagcccuuua gcggaugcaa a                                                 21





<210>  1791

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1791

cccaccguuu cuggcauguc a                                                 21





<210>  1792

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1792

uucaguaaug cugcucgugu a                                                 21





<210>  1793

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1793

gccgguuauu cagacccuau a                                                 21





<210>  1794

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1794

acgcugguuc auguccgcuu a                                                 21





<210>  1795

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1795

cacgcucgug ucagacaggu u                                                 21





<210>  1796

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1796

ucaauugguu cgagugagua a                                                 21





<210>  1797

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1797

cacgaaaucu ugcucgggca a                                                 21





<210>  1798

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1798

cagcggcaga ugacugaaca a                                                 21





<210>  1799

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1799

cugggucagc auagaaugcu a                                                 21





<210>  1800

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1800

uugaauguag ugauucauca a                                                 21





<210>  1801

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1801

gacaguggac uacaugauaa a                                                 21





<210>  1802

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1802

cagaagcgaa gcagaggcga a                                                 21





<210>  1803

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1803

caggagauuu aggguaaguc a                                                 21





<210>  1804

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1804

uaagaaggac cugauaugua a                                                 21





<210>  1805

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1805

aacgcugguu aaauuggugu a                                                 21





<210>  1806

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1806

ccgaaggaua uuacagccga a                                                 21





<210>  1807

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1807

aaggauaccu acgugaugaa a                                                 21





<210>  1808

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1808

ugggcuagau acaucacauu a                                                 21





<210>  1809

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1809

uugcauauuu augcaaggua u                                                 21





<210>  1810

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1810

gagguucguu acagcauugu a                                                 21





<210>  1811

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1811

aagaugaaau uugcucugcu a                                                 21





<210>  1812

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1812

acgggauuag aggauuuccu a                                                 21





<210>  1813

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1813

cuggcaguga auggucugua u                                                 21





<210>  1814

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1814

gacgacagcu uugauaagaa u                                                 21





<210>  1815

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1815

cacaaugguc ucguucccuu a                                                 21





<210>  1816

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1816

cagguucuag caagaggaga a                                                 21





<210>  1817

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1817

gagcagaaug augucgacga a                                                 21





<210>  1818

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1818

ccggugcacu guucgccgaa a                                                 21





<210>  1819

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1819

acgggugaga cuguuguuga a                                                 21





<210>  1820

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1820

aagguauaua ggcccgcaga a                                                 21





<210>  1821

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1821

cagcgagguc uccacaguuu a                                                 21





<210>  1822

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1822

agcgauaagg auccuaugcu a                                                 21





<210>  1823

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1823

caccuaguac uccucgguca a                                                 21





<210>  1824

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1824

auggcucuag cuaguaguca a                                                 21





<210>  1825

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1825

aucccgauuc ugguuuaauu a                                                 21





<210>  1826

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1826

ugggauuaug ggcacuuauu a                                                 21





<210>  1827

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1827

aaggucuuug guaaagucac a                                                 21





<210>  1828

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1828

uggacuugga uggguauuaa a                                                 21





<210>  1829

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1829

caggcauaau ugaugcaacu a                                                 21





<210>  1830

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1830

acacgucaaa guaagaagca a                                                 21





<210>  1831

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1831

cggcgaaacc accuacaaga a                                                 21





<210>  1832

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1832

ccgcgucgug gucaugaaca a                                                 21





<210>  1833

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1833

cgcgcccgcc accgacaucu a                                                 21





<210>  1834

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1834

ccgccgccuc uuucuuguuu a                                                 21





<210>  1835

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1835

cacccucgug aguaaccugu a                                                 21





<210>  1836

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1836

ccguguuugc ugaaugcaca a                                                 21





<210>  1837

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1837

caggaccaac gucaagggua u                                                 21





<210>  1838

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1838

agcccuagug gucaacucau a                                                 21





<210>  1839

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1839

caccguggac auccacauga a                                                 21





<210>  1840

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1840

cucugcggag uucuucaacu a                                                 21





<210>  1841

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1841

ccggguguuu cuggccgugu u                                                 21





<210>  1842

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1842

cccggacaug gccuucugua a                                                 21





<210>  1843

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1843

gcggauccgg ucgaaauaga a                                                 21





<210>  1844

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1844

cagggcaguc aauccaauca u                                                 21





<210>  1845

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1845

gaagguguau augcucuaua a                                                 21





<210>  1846

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1846

cugcgaauug ggaaucagua a                                                 21





<210>  1847

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1847

augcagguag ugagaauuga a                                                 21





<210>  1848

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1848

aucggcccuu ugagacagua a                                                 21





<210>  1849

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1849

aagcaggaac ucaggcggaa a                                                 21





<210>  1850

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1850

gagacgaauu aaauuaggau a                                                 21





<210>  1851

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1851

aacagcaaau uccaucgugu a                                                 21





<210>  1852

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1852

gaccuacgaa uuggagauga a                                                 21





<210>  1853

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1853

cacaggagga aagagcaucu a                                                 21





<210>  1854

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1854

ugcggccgau gagaagaaga a                                                 21





<210>  1855

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1855

aagcgagaca uaacccuaga a                                                 21





<210>  1856

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1856

cugcagauga uuugcggauu a                                                 21





<210>  1857

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1857

auggaaggua uagagauccu a                                                 21





<210>  1858

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1858

cccggucuug guggugguau a                                                 21





<210>  1859

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1859

ugggaaggua uuuaccuaca a                                                 21





<210>  1860

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1860

accggccuca caaguguucu a                                                 21





<210>  1861

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1861

cagaaggcua cagaugugaa a                                                 21





<210>  1862

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1862

ugccagugaa gugaagaccu a                                                 21





<210>  1863

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1863

cacagagaac ucaaacguuc a                                                 21





<210>  1864

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1864

acaguggaua uuccuggcua a                                                 21





<210>  1865

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1865

ugaccuaagc cugguaguua a                                                 21





<210>  1866

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1866

aaccaaggaa ccagacccga a                                                 21





<210>  1867

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1867

uaggacaugg auauguuaca a                                                 21





<210>  1868

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1868

cggaugggau ucacuuaaga a                                                 21





<210>  1869

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1869

uuggaauacu cuaagagaau a                                                 21





<210>  1870

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1870

cgcauggaug aucacgaaac a                                                 21





<210>  1871

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1871

cuggugauua cauggaucca a                                                 21





<210>  1872

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1872

augcugagcu uuaucauauc a                                                 21





<210>  1873

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1873

cuacagauuc uugccacaga a                                                 21





<210>  1874

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1874

aaggagacuc auguaaugga u                                                 21





<210>  1875

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1875

caagauuaua auauugcuga a                                                 21





<210>  1876

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1876

cuccuugacu guggacaaca a                                                 21





<210>  1877

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1877

auggagguua uuauaguaua u                                                 21





<210>  1878

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1878

aagguacgua gguuuaauuc a                                                 21





<210>  1879

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1879

augccagcga gaacgucaau a                                                 21





<210>  1880

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1880

cugcgguggg aucugaguau a                                                 21





<210>  1881

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1881

cgguucuguc agggucccua a                                                 21





<210>  1882

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1882

ugcgguggga ucugaguaua u                                                 21





<210>  1883

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1883

aaagaggauu cagcugacaa a                                                 21





<210>  1884

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1884

cagcauugga ccuugcuuaa a                                                 21





<210>  1885

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1885

aagcaacaug guacaccuug a                                                 21





<210>  1886

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1886

cuggacgauu ggaccauucc a                                                 21





<210>  1887

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1887

ccggguuuag gacgugguca a                                                 21





<210>  1888

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1888

gcaggucuug uugccaauuu a                                                 21





<210>  1889

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1889

caggaaagau uugguguugu a                                                 21





<210>  1890

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1890

cuggguccgg uccauaauca u                                                 21





<210>  1891

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1891

uugaaauaca gucuccacuu a                                                 21





<210>  1892

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1892

aaggaauacu ucuauuaacc a                                                 21





<210>  1893

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1893

cagcugcauu agauguaacu a                                                 21





<210>  1894

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1894

ucgggaaaua gaggcaacca a                                                 21





<210>  1895

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1895

accgcuguaa cuccuaugau a                                                 21





<210>  1896

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1896

cccgcucaga uuaucauguc a                                                 21





<210>  1897

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1897

uaggcaguuc ugugagucaa a                                                 21





<210>  1898

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1898

ccugaugaau cuacugcuaa a                                                 21





<210>  1899

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1899

cagaguggac agaaagcauu a                                                 21





<210>  1900

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1900

cagguuagcu agguagaguu a                                                 21





<210>  1901

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1901

cucggcuguu cugauuuauu a                                                 21





<210>  1902

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1902

cccgugcaug aacuccuucg a                                                 21





<210>  1903

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1903

cagggugacc cuaugagggu a                                                 21





<210>  1904

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1904

cacuaggguc caaauacaga a                                                 21





<210>  1905

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1905

ucggaugauc uuaaaccuuu g                                                 21





<210>  1906

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1906

ccugguggcu uaugugauca a                                                 21





<210>  1907

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1907

cagcaacaac auaauagaca a                                                 21





<210>  1908

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1908

caggaagauc agggaggcua a                                                 21





<210>  1909

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1909

aucaaggauc ucagaaucaa a                                                 21





<210>  1910

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1910

uacagucaga uggaccgaca a                                                 21





<210>  1911

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1911

cugcuggauu acaucgacaa a                                                 21





<210>  1912

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1912

uuccaaucgg gucaucauua a                                                 21





<210>  1913

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1913

uugggauuuc gacgugugca a                                                 21





<210>  1914

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1914

auggccgucg ucaucccaga a                                                 21





<210>  1915

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1915

gaggcagaug uuugucaaca a                                                 21





<210>  1916

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1916

cagguucuag ugacaauuca a                                                 21





<210>  1917

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1917

caaguucaag aucaagauca u                                                 21





<210>  1918

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1918

ucccugaagu cucuagaucu a                                                 21





<210>  1919

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1919

ccaccuugau gucuaccuua a                                                 21





<210>  1920

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1920

aacauacgca cuggucuugu a                                                 21





<210>  1921

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1921

aaauguugua auccugcuaa a                                                 21





<210>  1922

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1922

ccacuggacc cucuacauga a                                                 21





<210>  1923

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1923

caggacaugu cuuacgauga a                                                 21





<210>  1924

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1924

uaccaccucg agugcaauga a                                                 21





<210>  1925

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1925

caccgacgag guagacagca a                                                 21





<210>  1926

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1926

cacgauguua caagaacgau u                                                 21





<210>  1927

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1927

aggaauugcg aauacaugua a                                                 21





<210>  1928

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1928

cggccaggaa ccacccguua a                                                 21





<210>  1929

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1929

cccaugcuuc ucugcgcaau a                                                 21





<210>  1930

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1930

ucguaacauu acuguggaua a                                                 21





<210>  1931

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1931

agggacuacu ucugaacucu a                                                 21





<210>  1932

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1932

cugguacaga gaaaucgaca a                                                 21





<210>  1933

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1933

cagaggcgga uagaacggau a                                                 21





<210>  1934

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1934

caugaugaca uagaaguacu a                                                 21





<210>  1935

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1935

aacgagaaau ugcggaagcu a                                                 21





<210>  1936

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1936

cugccgaauu cuaccagugu a                                                 21





<210>  1937

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1937

caggcgaaua uacucacauc a                                                 21





<210>  1938

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1938

ugcgcauagg caagucauuu a                                                 21





<210>  1939

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1939

accguguuug accagcuagu a                                                 21





<210>  1940

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1940

cagcccuacu aaagacaucg a                                                 21





<210>  1941

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1941

caggcgucac auaaagugug a                                                 21





<210>  1942

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1942

cgcggaccac uuuaaacugu a                                                 21





<210>  1943

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1943

uagguccuuc caggaacuca a                                                 21





<210>  1944

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1944

cucgggcuau uucguuagca u                                                 21





<210>  1945

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1945

caguaugaau cuugacgguu u                                                 21





<210>  1946

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1946

cagguucggu aaauaaacaa u                                                 21





<210>  1947

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1947

cugccuuuac ugucuccguu a                                                 21





<210>  1948

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1948

cuggaggacc gaggcuuacu a                                                 21





<210>  1949

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1949

uacuuaguga uacacguaua a                                                 21





<210>  1950

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1950

cagcauccug gccguguuga a                                                 21





<210>  1951

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1951

aagcgaucua ccacuacaga a                                                 21





<210>  1952

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1952

ugggagcacu guauuacaac a                                                 21





<210>  1953

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1953

aacggccuuu cagucagacu a                                                 21





<210>  1954

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1954

cacgguguuu ggagugugcu u                                                 21





<210>  1955

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1955

accgaauguc uuagugaacu a                                                 21





<210>  1956

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1956

cuggagaucc uuacaguguu a                                                 21





<210>  1957

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1957

caagugguca ucccuaucuu a                                                 21





<210>  1958

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1958

cugggagauc augcagguug a                                                 21





<210>  1959

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1959

ugggaucaaa guugucauga a                                                 21





<210>  1960

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1960

uagccguuac aaacuccauu a                                                 21





<210>  1961

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1961

auggagugug ucugcacuac a                                                 21





<210>  1962

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1962

cgggcuggcu gaagcaaccu a                                                 21





<210>  1963

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1963

uuccauauga cuuaucuaac a                                                 21





<210>  1964

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1964

cagcagacca uggauaacuu a                                                 21





<210>  1965

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1965

cugcuuagag auguucacga a                                                 21





<210>  1966

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1966

cugguugaac ucccuaaaug a                                                 21





<210>  1967

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1967

auggagcaau cucaaccucu a                                                 21





<210>  1968

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1968

uccuaugacu uuacucaauu a                                                 21





<210>  1969

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1969

uuggacuaug aagccgguga a                                                 21





<210>  1970

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1970

cgccggcagc uaccagguaa a                                                 21





<210>  1971

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1971

cagagcauau cuauuauagc a                                                 21





<210>  1972

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1972

auccggaaga uaaagaaagu a                                                 21





<210>  1973

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1973

caccuaaacc uucgagauca u                                                 21





<210>  1974

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1974

caaucgauau uugaaucaca a                                                 21





<210>  1975

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1975

ggcguuguuc uugacacuca a                                                 21





<210>  1976

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1976

acagcacaug uugauuacga a                                                 21





<210>  1977

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1977

caucguaaac ucgguguuga a                                                 21





<210>  1978

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1978

cugguaccuu auccgagaau a                                                 21





<210>  1979

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1979

agagaugcua auggaauuua a                                                 21





<210>  1980

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1980

cacaugcuca auaacccuga a                                                 21





<210>  1981

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1981

ccagaggaaa uucgugugaa a                                                 21





<210>  1982

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1982

cacacuggcc uuuguaaaua a                                                 21





<210>  1983

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1983

uacgaugaua ugcggguguu a                                                 21





<210>  1984

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1984

cagcuuaaua gcaaggaggu a                                                 21





<210>  1985

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1985

aagauuauca auaaucggag a                                                 21





<210>  1986

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1986

aaccguuagc ucacuuaaug a                                                 21





<210>  1987

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1987

cccaggaucg ugauaacugu a                                                 21





<210>  1988

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1988

ugcggagagg uucacaacaa a                                                 21





<210>  1989

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1989

gcggaaggac auacuuauga a                                                 21





<210>  1990

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1990

aagcacagua gcaaacucau a                                                 21





<210>  1991

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1991

accgaugauu uagaugagcu u                                                 21





<210>  1992

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1992

accgaauauc caguauuggu a                                                 21





<210>  1993

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1993

cagcgacuca uucuccaaua u                                                 21





<210>  1994

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1994

caccuacgcu ggacaguaua a                                                 21





<210>  1995

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1995

acccgugaua uuaagcaauu a                                                 21





<210>  1996

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1996

caggauggac ggcaagugaa a                                                 21





<210>  1997

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1997

cagacgcuau gccuggauaa a                                                 21





<210>  1998

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1998

cugcgccgac cucuuugucu a                                                 21





<210>  1999

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  1999

cagcggcguc ugauacgcca a                                                 21





<210>  2000

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2000

aacggcguuu aucuucgcua u                                                 21





<210>  2001

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2001

cucgcgcguc cuguacggca a                                                 21





<210>  2002

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2002

cacgaguuug gauguuguaa a                                                 21





<210>  2003

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2003

agggagcaaa uagauaccua a                                                 21





<210>  2004

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2004

caggagauag uacguugucg a                                                 21





<210>  2005

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2005

uaagguggag uggauacgaa a                                                 21





<210>  2006

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2006

aagcgguuug cugacaauac a                                                 21





<210>  2007

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2007

augcugauag uuuacuggca a                                                 21





<210>  2008

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2008

aucuuccguu aggccaauaa a                                                 21





<210>  2009

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2009

cggaaguacg agugcacaau a                                                 21





<210>  2010

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2010

uggacgcaaa uuuauccaga a                                                 21





<210>  2011

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2011

uacgcuaaua agugacaaau a                                                 21





<210>  2012

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2012

aacuacgcac uccuuugaca a                                                 21





<210>  2013

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2013

ccggcucaac ucgcaucuca a                                                 21





<210>  2014

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic Construct



<400>  2014

acgcuaauaa gugacaaaua a                                                 21





<210>  2015

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic construct



<400>  2015

uaauacucgc cuaugaugcc a                                                 21





<210>  2016

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic construct



<400>  2016

aucuacacga aguccaucca g                                                 21





<210>  2017

<211>  21

<212>  RNA

<213>  ARTIFICIAL SEQUENCE



<220>

<223>  Synthetic construct



<400>  2017

uuggccucgg gaccaagcgu g                                                 21





