                         SEQUENCE LISTING

<110>  de Wal, Janneke
       Gaudet, Daniel
       Amsterdam Molecular Therapeutics (AMT) IP B.V.
 
<120>  Use of lipoprotein lipase (LPL) in therapy 

<130>  P6031130PCT

<150>  US 61/179,253
<151>  2009-05-18

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  3747
<212>  DNA
<213>  Homo sapiens

<400>  1
aaatttttcc gtctgccctt tccccctctt ctcgttggca gggttgatcc tcattactgt     60

ttgctcaaac gtttagaagt gaatttaggt ccctcccccc aacttatgat tttatagcca    120

ataggtgatg aggtttattt gcatatttcc agtcacataa gcagccttgg cgtgaaaaca    180

gtgtcagact cgattccccc tcttcctcct cctcaaggga aagctgccca cttctagctg    240

ccctgccatc ccctttaaag ggcgacttgc tcagcgccaa accgcggctc cagccctctc    300

cagcctccgg ctcagccggc tcatcagtcg gtccgcgcct tgcagctcct ccagagggac    360

gcgccccgag atggagagca aagccctgct cgtgctgact ctggccgtgt ggctccagag    420

tctgaccgcc tcccgcggag gggtggccgc cgccgaccaa agaagagatt ttatcgacat    480

cgaaagtaaa tttgccctaa ggacccctga agacacagct gaggacactt gccacctcat    540

tcccggagta gcagagtccg tggctacctg tcatttcaat cacagcagca aaaccttcat    600

ggtgatccat ggctggacgg taacaggaat gtatgagagt tgggtgccaa aacttgtggc    660

cgccctgtac aagagagaac cagactccaa tgtcattgtg gtggactggc tgtcacgggc    720

tcaggagcat tacccagtgt ccgcgggcta caccaaactg gtgggacagg atgtggcccg    780

gtttatcaac tggatggagg aggagtttaa ctaccctctg gacaatgtcc atctcttggg    840

atacagcctt ggagcccatg ctgctggcat tgcaggaagt ctgaccaata agaaagtcaa    900

cagaattact ggcctcgatc cagctggacc taactttgag tatgcagaag ccccgagtcg    960

tctttctcct gatgatgcag attttgtaga cgtcttacac acattcacca gagggtcccc   1020

tggtcgaagc attggaatcc agaaaccagt tgggcatgtt gacatttacc cgaatggagg   1080

tacttttcag ccaggatgta acattggaga agctatccgc gtgattgcag agagaggact   1140

tggagatgtg gaccagctag tgaagtgctc ccacgagcgc tccattcatc tcttcatcga   1200

ctctctgttg aatgaagaaa atccaagtaa ggcctacagg tgcagttcca aggaagcctt   1260

tgagaaaggg ctctgcttga gttgtagaaa gaaccgctgc aacaatctgg gctatgagat   1320

caataaagtc agagccaaaa gaagcagcaa aatgtacctg aagactcgtt ctcagatgcc   1380

ctacaaagtc ttccattacc aagtaaagat tcatttttct gggactgaga gtgaaaccca   1440

taccaatcag gcctttgaga tttctctgta tggcaccgtg gccgagagtg agaacatccc   1500

attcactctg cctgaagttt ccacaaataa gacctactcc ttcctaattt acacagaggt   1560

agatattgga gaactactca tgttgaagct caaatggaag agtgattcat actttagctg   1620

gtcagactgg tggagcagtc ccggcttcgc cattcagaag atcagagtaa aagcaggaga   1680

gactcagaaa aaggtgatct tctgttctag ggagaaagtg tctcatttgc agaaaggaaa   1740

ggcacctgcg gtatttgtga aatgccatga caagtctctg aataagaagt caggctgaaa   1800

ctgggcgaat ctacagaaca aagaacggca tgtgaattct gtgaagaatg aagtggagga   1860

agtaactttt acaaaacata cccagtgttt ggggtgtttc aaaagtggat tttcctgaat   1920

attaatccca gccctaccct tgttagttat tttaggagac agtctcaagc actaaaaagt   1980

ggctaattca atttatgggg tatagtggcc aaatagcaca tcctccaacg ttaaaagaca   2040

gtggatcatg aaaagtgctg ttttgtcctt tgagaaagaa ataattgttt gagcgcagag   2100

taaaataagg ctccttcatg tggcgtattg ggccatagcc tataattggt tagaacctcc   2160

tattttaatt ggaattctgg atctttcgga ctgaggcctt ctcaaacttt actctaagtc   2220

tccaagaata cagaaaatgc ttttccgcgg cacgaatcag actcatctac acagcagtat   2280

gaatgatgtt ttagaatgat tccctcttgc tattggaatg tggtccagac gtcaaccagg   2340

aacatgtaac ttggagaggg acgaagaaag ggtctgataa acacagaggt tttaaacagt   2400

ccctaccatt ggcctgcatc atgacaaagt tacaaattca aggagatata aaatctagat   2460

caattaattc ttaataggct ttatcgttta ttgcttaatc cctctctccc ccttcttttt   2520

tgtctcaaga ttatattata ataatgttct ctgggtaggt gttgaaaatg agcctgtaat   2580

cctcagctga cacataattt gaatggtgca gaaaaaaaaa aagaaaccgt aattttatta   2640

ttagattctc caaatgattt tcatcaattt aaaatcattc aatatctgac agttactctt   2700

cagttttagg cttaccttgg tcatgcttca gttgtacttc cagtgcgtct cttttgttcc   2760

tggctttgac atgaaaagat aggtttgagt tcaaattttg cattgtgtga gcttctacag   2820

attttagaca aggaccgttt ttactaagta aaagggtgga gaggttcctg gggtggattc   2880

ctaagcagtg cttgtaaacc atcgcgtgca atgagccaga tggagtacca tgagggttgc   2940

tatttgttgt ttttaacaac taatcaagag tgagtgaaca actatttata aactagatct   3000

cctatttttc agaatgctct tctacgtata aatatgaaat gataaagatg tcaaatatct   3060

cagaggctat agctgggaac ccgactgtga aagtatgtga tatctgaaca catactagaa   3120

agctctgcat gtgtgttgtc cttcagcata attcggaagg gaaaacagtc gatcaaggga   3180

tgtattggaa catgtcggag tagaaattgt tcctgatgtg ccagaacttc gaccctttct   3240

ctgagagaga tgatcgtgcc tataaatagt aggaccaatg ttgtgattaa catcatcagg   3300

cttggaatga attctctcta aaaataaaat gatgtatgat ttgttgttgg catccccttt   3360

attaattcat taaatttctg gatttgggtt gtgacccagg gtgcattaac ttaaaagatt   3420

cactaaagca gcacatagca ctgggaactc tggctccgaa aaactttgtt atatatatca   3480

aggatgttct ggctttacat tttatttatt agctgtaaat acatgtgtgg atgtgtaaat   3540

ggagcttgta catattggaa aggtcattgt ggctatctgc atttataaat gtgtggtgct   3600

aactgtatgt gtctttatca gtgatggtct cacagagcca actcactctt atgaaatggg   3660

ctttaacaaa acaagaaaga aacgtactta actgtgtgaa gaaatggaat cagcttttaa   3720

taaaattgac aacattttat taccaca                                       3747


<210>  2
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ser Lys Ala Leu Leu Val Leu Thr Leu Ala Val Trp Leu Gln 
1               5                   10                  15      


Ser Leu Thr Ala Ser Arg Gly Gly Val Ala Ala Ala Asp Gln Arg Arg 
            20                  25                  30          


Asp Phe Ile Asp Ile Glu Ser Lys Phe Ala Leu Arg Thr Pro Glu Asp 
        35                  40                  45              


Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly Val Ala Glu Ser Val 
    50                  55                  60                  


Ala Thr Cys His Phe Asn His Ser Ser Lys Thr Phe Met Val Ile His 
65                  70                  75                  80  


Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val Pro Lys Leu Val 
                85                  90                  95      


Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn Val Ile Val Val Asp 
            100                 105                 110         


Trp Leu Ser Arg Ala Gln Glu His Tyr Pro Val Ser Ala Gly Tyr Thr 
        115                 120                 125             


Lys Leu Val Gly Gln Asp Val Ala Arg Phe Ile Asn Trp Met Glu Glu 
    130                 135                 140                 


Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu Leu Gly Tyr Ser Leu 
145                 150                 155                 160 


Gly Ala His Ala Ala Gly Ile Ala Gly Ser Leu Thr Asn Lys Lys Val 
                165                 170                 175     


Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Asn Phe Glu Tyr Ala 
            180                 185                 190         


Glu Ala Pro Ser Arg Leu Ser Pro Asp Asp Ala Asp Phe Val Asp Val 
        195                 200                 205             


Leu His Thr Phe Thr Arg Gly Ser Pro Gly Arg Ser Ile Gly Ile Gln 
    210                 215                 220                 


Lys Pro Val Gly His Val Asp Ile Tyr Pro Asn Gly Gly Thr Phe Gln 
225                 230                 235                 240 


Pro Gly Cys Asn Ile Gly Glu Ala Ile Arg Val Ile Ala Glu Arg Gly 
                245                 250                 255     


Leu Gly Asp Val Asp Gln Leu Val Lys Cys Ser His Glu Arg Ser Ile 
            260                 265                 270         


His Leu Phe Ile Asp Ser Leu Leu Asn Glu Glu Asn Pro Ser Lys Ala 
        275                 280                 285             


Tyr Arg Cys Ser Ser Lys Glu Ala Phe Glu Lys Gly Leu Cys Leu Ser 
    290                 295                 300                 


Cys Arg Lys Asn Arg Cys Asn Asn Leu Gly Tyr Glu Ile Asn Lys Val 
305                 310                 315                 320 


Arg Ala Lys Arg Ser Ser Lys Met Tyr Leu Lys Thr Arg Ser Gln Met 
                325                 330                 335     


Pro Tyr Lys Val Phe His Tyr Gln Val Lys Ile His Phe Ser Gly Thr 
            340                 345                 350         


Glu Ser Glu Thr His Thr Asn Gln Ala Phe Glu Ile Ser Leu Tyr Gly 
        355                 360                 365             


Thr Val Ala Glu Ser Glu Asn Ile Pro Phe Thr Leu Pro Glu Val Ser 
    370                 375                 380                 


Thr Asn Lys Thr Tyr Ser Phe Leu Ile Tyr Thr Glu Val Asp Ile Gly 
385                 390                 395                 400 


Glu Leu Leu Met Leu Lys Leu Lys Trp Lys Ser Asp Ser Tyr Phe Ser 
                405                 410                 415     


Trp Ser Asp Trp Trp Ser Ser Pro Gly Phe Ala Ile Gln Lys Ile Arg 
            420                 425                 430         


Val Lys Ala Gly Glu Thr Gln Lys Lys Val Ile Phe Cys Ser Arg Glu 
        435                 440                 445             


Lys Val Ser His Leu Gln Lys Gly Lys Ala Pro Ala Val Phe Val Lys 
    450                 455                 460                 


Cys His Asp Lys Ser Leu Asn Lys Lys Ser Gly 
465                 470                 475 


<210>  3
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Asp Gln Arg Arg Asp Phe Ile Asp Ile Glu Ser Lys Phe Ala Leu 
1               5                   10                  15      


Arg Thr Pro Glu Asp Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly 
            20                  25                  30          


Val Ala Glu Ser Val Ala Thr Cys His Phe Asn His Ser Ser Lys Thr 
        35                  40                  45              


Phe Met Val Ile His Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp 
    50                  55                  60                  


Val Pro Lys Leu Val Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn 
65                  70                  75                  80  


Val Ile Val Val Asp Trp Leu Ser Arg Ala Gln Glu His Tyr Pro Val 
                85                  90                  95      


Ser Ala Gly Tyr Thr Lys Leu Val Gly Gln Asp Val Ala Arg Phe Ile 
            100                 105                 110         


Asn Trp Met Glu Glu Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu 
        115                 120                 125             


Leu Gly Tyr Ser Leu Gly Ala His Ala Ala Gly Ile Ala Gly Ser Leu 
    130                 135                 140                 


Thr Asn Lys Lys Val Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro 
145                 150                 155                 160 


Asn Phe Glu Tyr Ala Glu Ala Pro Ser Arg Leu Ser Pro Asp Asp Ala 
                165                 170                 175     


Asp Phe Val Asp Val Leu His Thr Phe Thr Arg Gly Ser Pro Gly Arg 
            180                 185                 190         


Ser Ile Gly Ile Gln Lys Pro Val Gly His Val Asp Ile Tyr Pro Asn 
        195                 200                 205             


Gly Gly Thr Phe Gln Pro Gly Cys Asn Ile Gly Glu Ala Ile Arg Val 
    210                 215                 220                 


Ile Ala Glu Arg Gly Leu Gly Asp Val Asp Gln Leu Val Lys Cys Ser 
225                 230                 235                 240 


His Glu Arg Ser Ile His Leu Phe Ile Asp Ser Leu Leu Asn Glu Glu 
                245                 250                 255     


Asn Pro Ser Lys Ala Tyr Arg Cys Ser Ser Lys Glu Ala Phe Glu Lys 
            260                 265                 270         


Gly Leu Cys Leu Ser Cys Arg Lys Asn Arg Cys Asn Asn Leu Gly Tyr 
        275                 280                 285             


Glu Ile Asn Lys Val Arg Ala Lys Arg Ser Ser Lys Met Tyr Leu Lys 
    290                 295                 300                 


Thr Arg Ser Gln Met Pro Tyr Lys Val Phe His Tyr Gln Val Lys Ile 
305                 310                 315                 320 


His Phe Ser Gly Thr Glu Ser Glu Thr His Thr Asn Gln Ala Phe Glu 
                325                 330                 335     


Ile Ser Leu Tyr Gly Thr Val Ala Glu Ser Glu Asn Ile Pro Phe Thr 
            340                 345                 350         


Leu Pro Glu Val Ser Thr Asn Lys Thr Tyr Ser Phe Leu Ile Tyr Thr 
        355                 360                 365             


Glu Val Asp Ile Gly Glu Leu Leu Met Leu Lys Leu Lys Trp Lys Ser 
    370                 375                 380                 


Asp Ser Tyr Phe Ser Trp Ser Asp Trp Trp Ser Ser Pro Gly Phe Ala 
385                 390                 395                 400 


Ile Gln Lys Ile Arg Val Lys Ala Gly Glu Thr Gln Lys Lys Val Ile 
                405                 410                 415     


Phe Cys Ser Arg Glu Lys Val Ser His Leu Gln Lys Gly Lys Ala Pro 
            420                 425                 430         


Ala Val Phe Val Lys Cys His Asp Lys Ser Leu Asn Lys Lys Ser Gly 
        435                 440                 445             


<210>  4
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Asp Gln Arg Arg Asp Phe Ile Asp Ile Glu Ser Lys Phe Ala Leu 
1               5                   10                  15      


Arg Thr Pro Glu Asp Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly 
            20                  25                  30          


Val Ala Glu Ser Val Ala Thr Cys His Phe Asn His Ser Ser Lys Thr 
        35                  40                  45              


Phe Met Val Ile His Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp 
    50                  55                  60                  


Val Pro Lys Leu Val Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn 
65                  70                  75                  80  


Val Ile Val Val Asp Trp Leu Ser Arg Ala Gln Glu His Tyr Pro Val 
                85                  90                  95      


Ser Ala Gly Tyr Thr Lys Leu Val Gly Gln Asp Val Ala Arg Phe Ile 
            100                 105                 110         


Asn Trp Met Glu Glu Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu 
        115                 120                 125             


Leu Gly Tyr Ser Leu Gly Ala His Ala Ala Gly Ile Ala Gly Ser Leu 
    130                 135                 140                 


Thr Asn Lys Lys Val Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro 
145                 150                 155                 160 


Asn Phe Glu Tyr Ala Glu Ala Pro Ser Arg Leu Ser Pro Asp Asp Ala 
                165                 170                 175     


Asp Phe Val Asp Val Leu His Thr Phe Thr Arg Gly Ser Pro Gly Arg 
            180                 185                 190         


Ser Ile Gly Ile Gln Lys Pro Val Gly His Val Asp Ile Tyr Pro Asn 
        195                 200                 205             


Gly Gly Thr Phe Gln Pro Gly Cys Asn Ile Gly Glu Ala Ile Arg Val 
    210                 215                 220                 


Ile Ala Glu Arg Gly Leu Gly Asp Val Asp Gln Leu Val Lys Cys Ser 
225                 230                 235                 240 


His Glu Arg Ser Ile His Leu Phe Ile Asp Ser Leu Leu Asn Glu Glu 
                245                 250                 255     


Asn Pro Ser Lys Ala Tyr Arg Cys Ser Ser Lys Glu Ala Phe Glu Lys 
            260                 265                 270         


Gly Leu Cys Leu Ser Cys Arg Lys Asn Arg Cys Asn Asn Leu Gly Tyr 
        275                 280                 285             


Glu Ile Asn Lys Val Arg Ala Lys Arg Ser Ser Lys Met Tyr Leu Lys 
    290                 295                 300                 


Thr Arg Ser Gln Met Pro Tyr Lys Val Phe His Tyr Gln Val Lys Ile 
305                 310                 315                 320 


His Phe Ser Gly Thr Glu Ser Glu Thr His Thr Asn Gln Ala Phe Glu 
                325                 330                 335     


Ile Ser Leu Tyr Gly Thr Val Ala Glu Ser Glu Asn Ile Pro Phe Thr 
            340                 345                 350         


Leu Pro Glu Val Ser Thr Asn Lys Thr Tyr Ser Phe Leu Ile Tyr Thr 
        355                 360                 365             


Glu Val Asp Ile Gly Glu Leu Leu Met Leu Lys Leu Lys Trp Lys Ser 
    370                 375                 380                 


Asp Ser Tyr Phe Ser Trp Ser Asp Trp Trp Ser Ser Pro Gly Phe Ala 
385                 390                 395                 400 


Ile Gln Lys Ile Arg Val Lys Ala Gly Glu Thr Gln Lys Lys Val Ile 
                405                 410                 415     


Phe Cys Ser Arg Glu Lys Val Ser His Leu Gln Lys Gly Lys Ala Pro 
            420                 425                 430         


Ala Val Phe Val Lys Cys His Asp Lys Ser Leu Asn Lys Lys 
        435                 440                 445     


