                         SEQUENCE LISTING

<110>  The Queen's University of Belfast
       ROBSON, Tracy
       HIRST, David
       BYRNE, Christopher
       MCKEEN, Hayley
 
<120>  Assay method

<130>  P108265.WO.01

<150>  GB0908589.5
<151>  2009-05-19

<160>  5     

<170>  PatentIn version 3.3

<210>  1
<211>  1087
<212>  DNA
<213>  Homo sapiens

<400>  1
atggagacgc caccagtcaa tacaattgga gaaaaggaca cctctcagcc gcaacaagag     60

tgggaaaaga accttcggga gaaccttgat tcagttattc agattaggca gcagccccga    120

gaccctccta ccgaaacgct tgagctggaa gtaagcccag atccagccag ccaaattcta    180

gagcatactc aaggagctga aaaactggtt gctgaacttg aaggagactc tcataagtct    240

catggatcaa ccagtcagat gccagaggcc cttcaagctt ctgatctctg gtactgcccc    300

gatgggagct ttgtcaagaa gatcgtaatc cgtggccatg gcttggacaa acccaaacta    360

ggctcctgct gccgggtact ggctttgggg tttcctttcg gatcagggcc gccagagggc    420

tggacagagc taactatggg cgtagggcca tggagggagg aaacttgggg ggagctcata    480

gagaaatgct tggagtccat gtgtcaaggt gaggaagcag agcttcagct gcctgggcac    540

tctggacctc ctgtcaggct cacactggca tccttcactc aaggccgaga ctcctgggag    600

ctggagacta gcgagaagga agccctggcc agggaagaac gtgcaagggg cacagaacta    660

tttcgagctg ggaaccctga aggagctgcc cgatgctatg gacgggctct tcggctgctc    720

ctgactttac ccccacctgg ccctccagaa cgaactgtcc ttcatgccaa tctggctgcc    780

tgtcagttgt tgctagggca gcctcagttg gcagcccaga gctgtgaccg ggtgttggag    840

cgggagcctg gccatttaaa ggccttatac cgaagggggg ttgcccaggc tgcccttggg    900

aacctggaaa aagcaactgc tgacctcaag aaggtgctgg cgatagatcc caaaaaccgg    960

gcagcccagg aggaactggg gaaggtggtc attcagggga agaaccagga tgcagggctg   1020

gctcagggtc tgcgcaagat gtttggctga ttaaaagtta aaccttaaaa gagaaaaaaa   1080

aaaaaaa                                                             1087


<210>  2
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu 
        35                  40                  45              


Leu Glu Val Ser Pro Asp Pro Ala Ser Gln Ile Leu Glu His Thr Gln 
    50                  55                  60                  


Gly Ala Glu Lys Leu Val Ala Glu Leu Glu Gly Asp Ser His Lys Ser 
65                  70                  75                  80  


His Gly Ser Thr Ser Gln Met Pro Glu Ala Leu Gln Ala Ser Asp Leu 
                85                  90                  95      


Trp Tyr Cys Pro Asp Gly Ser Phe Val Lys Lys Ile Val Ile Arg Gly 
            100                 105                 110         


His Gly Leu Asp Lys Pro Lys Leu Gly Ser Cys Cys Arg Val Leu Ala 
        115                 120                 125             


Leu Gly Phe Pro Phe Gly Ser Gly Pro Pro Glu Gly Trp Thr Glu Leu 
    130                 135                 140                 


Thr Met Gly Val Gly Pro Trp Arg Glu Glu Thr Trp Gly Glu Leu Ile 
145                 150                 155                 160 


Glu Lys Cys Leu Glu Ser Met Cys Gln Gly Glu Glu Ala Glu Leu Gln 
                165                 170                 175     


Leu Pro Gly His Ser Gly Pro Pro Val Arg Leu Thr Leu Ala Ser Phe 
            180                 185                 190         


Thr Gln Gly Arg Asp Ser Trp Glu Leu Glu Thr Ser Glu Lys Glu Ala 
        195                 200                 205             


Leu Ala Arg Glu Glu Arg Ala Arg Gly Thr Glu Leu Phe Arg Ala Gly 
    210                 215                 220                 


Asn Pro Glu Gly Ala Ala Arg Cys Tyr Gly Arg Ala Leu Arg Leu Leu 
225                 230                 235                 240 


Leu Thr Leu Pro Pro Pro Gly Pro Pro Glu Arg Thr Val Leu His Ala 
                245                 250                 255     


Asn Leu Ala Ala Cys Gln Leu Leu Leu Gly Gln Pro Gln Leu Ala Ala 
            260                 265                 270         


Gln Ser Cys Asp Arg Val Leu Glu Arg Glu Pro Gly His Leu Lys Ala 
        275                 280                 285             


Leu Tyr Arg Arg Gly Val Ala Gln Ala Ala Leu Gly Asn Leu Glu Lys 
    290                 295                 300                 


Ala Thr Ala Asp Leu Lys Lys Val Leu Ala Ile Asp Pro Lys Asn Arg 
305                 310                 315                 320 


Ala Ala Gln Glu Glu Leu Gly Lys Val Val Ile Gln Gly Lys Asn Gln 
                325                 330                 335     


Asp Ala Gly Leu Ala Gln Gly Leu Arg Lys Met Phe Gly 
            340                 345                 


<210>  3
<211>  1087
<212>  DNA
<213>  Homo sapiens

<400>  3
atggagacgc caccagtcaa tacaattgga gaaaaggaca cctctcagcc gcaacaagag     60

tgggaaaaga accttcggga gaaccttgat tcagttattc agattaggca gcagccccga    120

gaccctccta ccgaaacgct tgagctggaa gtaagcccag atccagccag ccaaattcta    180

gagcatactc aaggagctga aaaactggtt gctgaacttg aaggagactc tcataagtct    240

catggatcaa ccagtcagat gccagaggcc cttcaagctt ctgatctctg gtactgcccc    300

gatgggagct ttgtcaagaa gatcgtaatc cgtggccatg gcttggacaa acccaaacta    360

ggctcctgct gccgggtact ggctttgggg tttcctttcg gatcagggcc gccagagggc    420

tggacagagc taactatggg cgtagggcca tggagggagg aaacttgggg ggagctcata    480

gagaaatgct tggagtccat gtgtcaaggt gaggaagcag agcttcagct gcctgggcac    540

actggacctc ctgtcgggct cacactggca tccttcactc aaggccgaga ctcctgggag    600

ctggagacta gcgagaagga agccctggcc agggaagaac gtgcaagggg cacagaacta    660

tttcgagctg ggaaccctga aggagctgcc cgatgctatg gacgggctct tcggctgctc    720

ctgactttac ccccacctgg ccctccagaa cgaactgtcc ttcatgccaa tctggctgcc    780

tgtcagttgt tgctagggca gcctcagttg gcagcccaga gctgtgaccg ggtgttggag    840

cgggagcctg gccatttaaa ggccttatac cgaagggggg ttgcccaggc tgcccttggg    900

aacctggaaa aagcaactgc tgacctcaag aaggtgctgg cgatagatcc caaaaaccgg    960

gcagcccagg aggaactggg gaaggtggtc attcagggga agaaccagga tgcagggctg   1020

gctcagggtc tgcgcaagat gtttggctga ttaaaagtta aaccttaaaa gagaaaaaaa   1080

aaaaaaa                                                             1087


<210>  4
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu 
        35                  40                  45              


Leu Glu Val Ser Pro Asp Pro Ala Ser Gln Ile Leu Glu His Thr Gln 
    50                  55                  60                  


Gly Ala Glu Lys Leu Val Ala Glu Leu Glu Gly Asp Ser His Lys Ser 
65                  70                  75                  80  


His Gly Ser Thr Ser Gln Met Pro Glu Ala Leu Gln Ala Ser Asp Leu 
                85                  90                  95      


Trp Tyr Cys Pro Asp Gly Ser Phe Val Lys Lys Ile Val Ile Arg Gly 
            100                 105                 110         


His Gly Leu Asp Lys Pro Lys Leu Gly Ser Cys Cys Arg Val Leu Ala 
        115                 120                 125             


Leu Gly Phe Pro Phe Gly Ser Gly Pro Pro Glu Gly Trp Thr Glu Leu 
    130                 135                 140                 


Thr Met Gly Val Gly Pro Trp Arg Glu Glu Thr Trp Gly Glu Leu Ile 
145                 150                 155                 160 


Glu Lys Cys Leu Glu Ser Met Cys Gln Gly Glu Glu Ala Glu Leu Gln 
                165                 170                 175     


Leu Pro Gly His Thr Gly Pro Pro Val Gly Leu Thr Leu Ala Ser Phe 
            180                 185                 190         


Thr Gln Gly Arg Asp Ser Trp Glu Leu Glu Thr Ser Glu Lys Glu Ala 
        195                 200                 205             


Leu Ala Arg Glu Glu Arg Ala Arg Gly Thr Glu Leu Phe Arg Ala Gly 
    210                 215                 220                 


Asn Pro Glu Gly Ala Ala Arg Cys Tyr Gly Arg Ala Leu Arg Leu Leu 
225                 230                 235                 240 


Leu Thr Leu Pro Pro Pro Gly Pro Pro Glu Arg Thr Val Leu His Ala 
                245                 250                 255     


Asn Leu Ala Ala Cys Gln Leu Leu Leu Gly Gln Pro Gln Leu Ala Ala 
            260                 265                 270         


Gln Ser Cys Asp Arg Val Leu Glu Arg Glu Pro Gly His Leu Lys Ala 
        275                 280                 285             


Leu Tyr Arg Arg Gly Val Ala Gln Ala Ala Leu Gly Asn Leu Glu Lys 
    290                 295                 300                 


Ala Thr Ala Asp Leu Lys Lys Val Leu Ala Ile Asp Pro Lys Asn Arg 
305                 310                 315                 320 


Ala Ala Gln Glu Glu Leu Gly Lys Val Val Ile Gln Gly Lys Asn Gln 
                325                 330                 335     


Asp Ala Gly Leu Ala Gln Gly Leu Arg Lys Met Phe Gly 
            340                 345                 


<210>  5
<211>  2281
<212>  DNA
<213>  Homo sapiens

<400>  5
tttcttgatg aaggaggact tgaaaggcaa tgatggatgt gaaaggaaag gtaaagagaa     60

gcctcaggta gtcacccaag ggacagggcc ggttggagag agagtcccga ggttttatcc    120

tggagaacac cctgtactga atgagctctg aacataaaga tagttagcat aggagggcct    180

gaagtctcca gataaaaggc tgctgccact atcatttacc acgacctctg ccattctcca    240

ctctattgtc atccgccccc agtctccatt ccaggacttc tctacacttt gactttttgt    300

ttgtttgttt gtttgtttga gacggagtct tgcgctgtcg cccaggctgg agcgcagtgg    360

cacgatcttg gctcaccgca agctccgcct tccgggttca tgccattctc ctgcctcagc    420

ctcccgggta gctgggacta taggtgcccg ccaccacgcc cagctaattt tttgtatttt    480

tagtagagac ggggtttcac catgttgtcc aggctggtct cgaacccctg acctcaagtg    540

atccccccgc cgccccgccc cctccccccg ccccgccccc ccccgccgcc tcggcctccc    600

aaattgctgg gattacaggc gtgcgcgatg cccggctttt tatttattta tttatttatt    660

tttgaggcgg gaatcttgct ctgtcgccag gctggattgc agtggcacca tctcggctca    720

ctgcaacctc cgactccctg gttcaagcga ttctcccacc tcagcctccc aagtagctgg    780

gattacaggc acacgccacc atgcccagct aactttttgt atttttagta gagacgagat    840

ttcaccatgt tgccaggatg gtctcgatca cctgacctcg tgatccgccc acctcagcct    900

cccagagtct cagttgccaa agctggagtg caatggcgcg atctcggctc actgcaacct    960

ccgcttccca ggtaagccat tctcctgcct cagcctcctg ggtagctggg atataggcgc   1020

ccgccatcac gccgagctat ttttgcattt ttagtagaga cggggtttca ccatgttggc   1080

caggctggtc ttgaactcct gacctcaacc tcccaaagtg ctgggattac aggcgtgagc   1140

caccgcgccc ggcccacctt tttttttttt tttttttttt ttttttgttt gagacggagt   1200

ctctagtctc gctctgtcgc ccaggctgga gtgcaatggt gtgatctcgg ctcactgcaa   1260

cgtctgtctc ccgggttcaa gcgattctcc tgtttcagcc ttccgagtag ttgggattac   1320

aggcgcgcgc caccatgacc tactaatttt tgtattttta gtagagacag ggtctcacca   1380

tgttggccca ctttgactct tgagcagcct ggccagcccg accgcgccaa attctgttcg   1440

attctgccta gttcggttgc tctggcctag ttcagttgct aaggcctgga gcttcatggt   1500

tgcggaggaa atgatgtcac gttcaatagg cgggctaacc agattcctcc cttctcccga   1560

ttggctgcca ggaatttgac tagattcgga gtctcgcggg ctccagggtt agttgtcagt   1620

atctttccca gttgttccgc cccctacccc cttggctgcc aggaatttga ctagattcgg   1680

agtctcgcgg gctccagggt tagttgtcag tatctttccc agttgttccg ccccctaccc   1740

ccgcctcccg caccgcgccc ctctccggct gccctctccg cgtggggcaa ggctccgagg   1800

gcagcattca gtagccattt agctttggaa ggagaggtga ttcgaatggc ccggctcctc   1860

ctgtcaccat gctaggcact ttggccgcgc aggtacttat tgacccgacc gggtgtccgt   1920

agttggcgcg gctaccttaa ccgcagggaa ttgtggaatt tatagttcta aattatatgt   1980

gggtggaacg gggaagctgg agcagatttt tggaggaaag caaaactggg gactttcagg   2040

actaggggcc tgggtctcag aagaatggga aaggacgaga aaggagtcta aataagaacc   2100

ctgctattag cattgtttgg ttttcttttc aggtgctgac ctgaacctgg ttcatccctt   2160

tctgaccaaa actgttcact caccgtggaa gggactaagc atccatatgg agacgccacc   2220

agtcaataca attggagaaa aggacacctc tcagccgcaa caagagtggg aaaagaacct   2280

t                                                                   2281


