                         SEQUENCE LISTING

<110>  Universit Joseph Fourier
       Vrije Universiteit Brussel
       BOTTARI, Serge
       VAUQUELIN, Georges
       TOURWE, Dirk
 
<120>  PEPTIDES MARQUES ET LEUR UTILISATION POUR LE DOSAGE D'IRAP 
       CIRCULANT

<130>  WOB 08 DB UJF PARI

<150>  FR 09/53392
<151>  2009-05-20

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  1025
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Xaa= Pro ou Ser

<220>
<221>  MISC_FEATURE
<222>  (763)..(763)
<223>  Xaa= Ala ou Thr

<220>
<221>  MISC_FEATURE
<222>  (963)..(963)
<223>  Xaa= Ile ou Val

<400>  1

Met Glu Pro Phe Thr Asn Asp Arg Leu Gln Leu Pro Arg Asn Met Ile 
1               5                   10                  15      


Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys 
            20                  25                  30          


Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro 
        35                  40                  45              


Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu 
    50                  55                  60                  


Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser 
65                  70                  75                  80  


Phe Met Asn Arg Ser Xaa Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg 
                85                  90                  95      


Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val 
            100                 105                 110         


Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile 
        115                 120                 125             


Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys 
    130                 135                 140                 


Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu 
145                 150                 155                 160 


Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg 
                165                 170                 175     


Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly 
            180                 185                 190         


Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile 
        195                 200                 205             


Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala 
    210                 215                 220                 


Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His 
225                 230                 235                 240 


Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn 
                245                 250                 255     


Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr 
            260                 265                 270         


Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr 
        275                 280                 285             


Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro 
    290                 295                 300                 


Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile 
305                 310                 315                 320 


Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser 
                325                 330                 335     


Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val 
            340                 345                 350         


Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn 
        355                 360                 365             


Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro 
    370                 375                 380                 


Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu 
385                 390                 395                 400 


Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys 
                405                 410                 415     


Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn 
            420                 425                 430         


Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn 
        435                 440                 445             


Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His 
    450                 455                 460                 


Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp 
465                 470                 475                 480 


Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe 
                485                 490                 495     


Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu 
            500                 505                 510         


Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His 
        515                 520                 525             


Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe 
    530                 535                 540                 


Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys 
545                 550                 555                 560 


Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu 
                565                 570                 575     


His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser 
            580                 585                 590         


Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys 
        595                 600                 605             


Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys 
    610                 615                 620                 


Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys 
625                 630                 635                 640 


Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu 
                645                 650                 655     


Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser 
            660                 665                 670         


Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu 
        675                 680                 685             


Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr 
    690                 695                 700                 


Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro 
705                 710                 715                 720 


Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe 
                725                 730                 735     


Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu 
            740                 745                 750         


Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Xaa Pro Ile Thr Glu Ala 
        755                 760                 765             


Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr 
    770                 775                 780                 


Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln 
785                 790                 795                 800 


Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met 
                805                 810                 815     


Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu 
            820                 825                 830         


Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala 
        835                 840                 845             


Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe 
    850                 855                 860                 


Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys 
865                 870                 875                 880 


Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala 
                885                 890                 895     


Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser 
            900                 905                 910         


Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile 
        915                 920                 925             


Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe 
    930                 935                 940                 


Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser 
945                 950                 955                 960 


Tyr Thr Xaa Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr 
                965                 970                 975     


Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu 
            980                 985                 990         


Ala Thr Phe Arg Leu Arg Cys Val  Gln Glu Ala Leu Glu  Val Ile Gln 
        995                 1000                 1005             


Leu Asn  Ile Gln Trp Met Glu  Lys Asn Leu Lys Ser  Leu Thr Trp 
    1010                 1015                 1020             


Trp Leu  
    1025 


<210>  2
<211>  1011
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa= Pro ou Ser

<220>
<221>  MISC_FEATURE
<222>  (749)..(749)
<223>  Xaa= Ala ou Thr

<220>
<221>  MISC_FEATURE
<222>  (949)..(949)
<223>  Xaa= Ile ou Val

<400>  2

Met Ile Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu 
1               5                   10                  15      


Ala Lys Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr 
            20                  25                  30          


Glu Pro Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu 
        35                  40                  45              


Met Glu Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly 
    50                  55                  60                  


Met Ser Phe Met Asn Arg Ser Xaa Gly Leu Arg Asn Ser Ala Thr Gly 
65                  70                  75                  80  


Tyr Arg Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr 
                85                  90                  95      


Met Val Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met 
            100                 105                 110         


Val Ile Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His 
        115                 120                 125             


Lys Lys Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly 
    130                 135                 140                 


Lys Leu Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro 
145                 150                 155                 160 


Leu Arg Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe 
                165                 170                 175     


Arg Gly Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn 
            180                 185                 190         


Ile Ile Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met 
        195                 200                 205             


Ser Ala Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala 
    210                 215                 220                 


Tyr His Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly 
225                 230                 235                 240 


His Asn Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser 
                245                 250                 255     


Tyr Tyr Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys 
            260                 265                 270         


Lys Tyr Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala 
        275                 280                 285             


Phe Pro Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys 
    290                 295                 300                 


Ile Ile Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys 
305                 310                 315                 320 


Ser Ser Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu 
                325                 330                 335     


Ser Val Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met 
            340                 345                 350         


Lys Asn Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala 
        355                 360                 365             


Val Pro Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val 
    370                 375                 380                 


Lys Leu Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu 
385                 390                 395                 400 


Lys Lys Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met 
                405                 410                 415     


Glu Asn Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp 
            420                 425                 430         


Ser Asn Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile 
        435                 440                 445             


Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys 
    450                 455                 460                 


Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu 
465                 470                 475                 480 


Tyr Phe Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp 
                485                 490                 495     


Phe Leu Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser 
            500                 505                 510         


Ser His Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu 
        515                 520                 525             


Met Phe Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met 
    530                 535                 540                 


Leu Lys Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu 
545                 550                 555                 560 


Tyr Leu His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp 
                565                 570                 575     


Asp Ser Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met 
            580                 585                 590         


Met Lys Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln 
        595                 600                 605             


Lys Lys Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn 
    610                 615                 620                 


Met Lys Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile 
625                 630                 635                 640 


Pro Leu Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser 
                645                 650                 655     


Val Ser Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu 
            660                 665                 670         


Val Leu Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val 
        675                 680                 685             


His Tyr Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile 
    690                 695                 700                 


Asn Pro Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn 
705                 710                 715                 720 


Ile Phe Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe 
                725                 730                 735     


Asp Leu Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Xaa Pro Ile Thr 
            740                 745                 750         


Glu Ala Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu 
        755                 760                 765             


Gly Tyr Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu 
    770                 775                 780                 


Leu Gln Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro 
785                 790                 795                 800 


Ser Met Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His 
                805                 810                 815     


Asn Leu Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp 
            820                 825                 830         


Met Ala Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr 
        835                 840                 845             


Val Phe Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu 
    850                 855                 860                 


Gly Lys Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu 
865                 870                 875                 880 


Glu Ala Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met 
                885                 890                 895     


Lys Ser Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe 
            900                 905                 910         


Ile Ile Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp 
        915                 920                 925             


Asp Phe Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu 
    930                 935                 940                 


Gly Ser Tyr Thr Xaa Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe 
945                 950                 955                 960 


Ser Thr Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln 
                965                 970                 975     


Ser Glu Ala Thr Phe Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val 
            980                 985                 990         


Ile Gln Leu Asn Ile Gln Trp Met  Glu Lys Asn Leu Lys  Ser Leu Thr 
        995                 1000                 1005             


Trp Trp  Leu 
    1010     


<210>  3
<211>  1006
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa= Pro ou Ser

<220>
<221>  MISC_FEATURE
<222>  (744)..(744)
<223>  Xaa= Ala ou Thr

<220>
<221>  misc_feature
<222>  (944)..(944)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (949)..(949)
<223>  Xaa= Ile ou Val

<400>  3

Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys Glu Pro Cys 
1               5                   10                  15      


Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro Arg Gly Ser 
            20                  25                  30          


Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu Glu Asp Glu 
        35                  40                  45              


Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser Phe Met Asn 
    50                  55                  60                  


Arg Ser Xaa Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg Gln Ser Pro 
65                  70                  75                  80  


Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val Val Cys Ala 
                85                  90                  95      


Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile Tyr Leu Leu 
            100                 105                 110         


Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys Asn Gln Ser 
        115                 120                 125             


Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu Phe Pro Trp 
    130                 135                 140                 


Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg Tyr Glu Leu 
145                 150                 155                 160 


Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly Ser Val Thr 
                165                 170                 175     


Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile Leu His Ser 
            180                 185                 190         


Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala Val Ser Ser 
        195                 200                 205             


Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His Gly Gln Ile 
    210                 215                 220                 


Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn Tyr Thr Leu 
225                 230                 235                 240 


Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr Gly Phe Tyr 
                245                 250                 255     


Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr Phe Ala Ala 
            260                 265                 270         


Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro Cys Phe Asp 
        275                 280                 285             


Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile Arg Asp Glu 
    290                 295                 300                 


Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser Val Val Leu 
305                 310                 315                 320 


Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val Lys Met Ser 
                325                 330                 335     


Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn Leu Ser Gln 
            340                 345                 350         


Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro Glu Lys Ile 
        355                 360                 365             


Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu Leu Glu Phe 
    370                 375                 380                 


Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys Leu Asp Leu 
385                 390                 395                 400 


Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn Trp Gly Leu 
                405                 410                 415     


Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn Thr Ser Ser 
            420                 425                 430         


Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His Glu Leu Ala 
        435                 440                 445             


His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp Asn Asp Leu 
    450                 455                 460                 


Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe Ser Leu Glu 
465                 470                 475                 480 


Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu Asp Ala Arg 
                485                 490                 495     


Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His Pro Ile Ser 
            500                 505                 510         


Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe Asp Ser Leu 
        515                 520                 525             


Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys Thr Tyr Leu 
    530                 535                 540                 


Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu His Asn His 
545                 550                 555                 560 


Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser Phe Asn Glu 
                565                 570                 575     


Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys Thr Trp Thr 
            580                 585                 590         


Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys Gly Lys Glu 
        595                 600                 605             


Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys Pro Glu Ile 
    610                 615                 620                 


Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu Ser Tyr Val 
625                 630                 635                 640 


Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser Leu Leu Asp 
                645                 650                 655     


Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu Trp Val Lys 
            660                 665                 670         


Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr Ala Asp Asp 
        675                 680                 685             


Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro Tyr Val Leu 
    690                 695                 700                 


Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe Glu Leu Ala 
705                 710                 715                 720 


Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu Ile Asn Tyr 
                725                 730                 735     


Leu Gly Asn Glu Asn His Thr Xaa Pro Ile Thr Glu Ala Leu Phe Gln 
            740                 745                 750         


Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr Met Asp Leu 
        755                 760                 765             


Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln Asn Gln Ile 
    770                 775                 780                 


Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met Arg Glu Leu 
785                 790                 795                 800 


Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu Gly Asn Cys 
                805                 810                 815     


Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala Ser Asn Gly 
            820                 825                 830         


Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe Lys Val Gly 
        835                 840                 845             


Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys Tyr Ile Ser 
    850                 855                 860                 


Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala Leu Ala Ser 
865                 870                 875                 880 


Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser Ser Leu Asn 
                885                 890                 895     


Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile Arg Thr Val 
            900                 905                 910         


Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe Val Lys Glu 
        915                 920                 925             


Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser Tyr Thr Xaa 
    930                 935                 940                 


Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr Lys Thr His 
945                 950                 955                 960 


Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu Ala Thr Phe 
                965                 970                 975     


Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile Gln Leu Asn Ile 
            980                 985                 990         


Gln Trp Met Glu Lys Asn Leu Lys  Ser Leu Thr Trp Trp  Leu 
        995                 1000                 1005     


<210>  4
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Pro Phe Thr Asn Asp Arg Leu Gln Leu Pro Arg Asn Met Ile 
1               5                   10                  15      


Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys 
            20                  25                  30          


Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro 
        35                  40                  45              


Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu 
    50                  55                  60                  


Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser 
65                  70                  75                  80  


Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg 
                85                  90                  95      


Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val 
            100                 105                 110         


Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile 
        115                 120                 125             


Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys 
    130                 135                 140                 


Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu 
145                 150                 155                 160 


Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg 
                165                 170                 175     


Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly 
            180                 185                 190         


Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile 
        195                 200                 205             


Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala 
    210                 215                 220                 


Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His 
225                 230                 235                 240 


Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn 
                245                 250                 255     


Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr 
            260                 265                 270         


Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr 
        275                 280                 285             


Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro 
    290                 295                 300                 


Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile 
305                 310                 315                 320 


Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser 
                325                 330                 335     


Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val 
            340                 345                 350         


Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn 
        355                 360                 365             


Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro 
    370                 375                 380                 


Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu 
385                 390                 395                 400 


Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys 
                405                 410                 415     


Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn 
            420                 425                 430         


Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn 
        435                 440                 445             


Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His 
    450                 455                 460                 


Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp 
465                 470                 475                 480 


Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe 
                485                 490                 495     


Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu 
            500                 505                 510         


Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His 
        515                 520                 525             


Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe 
    530                 535                 540                 


Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys 
545                 550                 555                 560 


Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu 
                565                 570                 575     


His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser 
            580                 585                 590         


Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys 
        595                 600                 605             


Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys 
    610                 615                 620                 


Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys 
625                 630                 635                 640 


Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu 
                645                 650                 655     


Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser 
            660                 665                 670         


Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu 
        675                 680                 685             


Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr 
    690                 695                 700                 


Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro 
705                 710                 715                 720 


Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe 
                725                 730                 735     


Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu 
            740                 745                 750         


Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala 
        755                 760                 765             


Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr 
    770                 775                 780                 


Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln 
785                 790                 795                 800 


Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met 
                805                 810                 815     


Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu 
            820                 825                 830         


Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala 
        835                 840                 845             


Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe 
    850                 855                 860                 


Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys 
865                 870                 875                 880 


Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala 
                885                 890                 895     


Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser 
            900                 905                 910         


Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile 
        915                 920                 925             


Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe 
    930                 935                 940                 


Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser 
945                 950                 955                 960 


Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr 
                965                 970                 975     


Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu 
            980                 985                 990         


Ala Thr Phe Arg Leu Arg Cys Val  Gln Glu Ala Leu Glu  Val Ile Gln 
        995                 1000                 1005             


Leu Asn  Ile Gln Trp Met Glu  Lys Asn Leu Lys Ser  Leu Thr Trp 
    1010                 1015                 1020             


Trp Leu  
    1025 


<210>  5
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Pro Phe Thr Asn Asp Arg Leu Gln Leu Pro Arg Asn Met Ile 
1               5                   10                  15      


Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys 
            20                  25                  30          


Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro 
        35                  40                  45              


Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu 
    50                  55                  60                  


Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser 
65                  70                  75                  80  


Phe Met Asn Arg Ser Pro Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg 
                85                  90                  95      


Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val 
            100                 105                 110         


Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile 
        115                 120                 125             


Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys 
    130                 135                 140                 


Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu 
145                 150                 155                 160 


Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg 
                165                 170                 175     


Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly 
            180                 185                 190         


Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile 
        195                 200                 205             


Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala 
    210                 215                 220                 


Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His 
225                 230                 235                 240 


Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn 
                245                 250                 255     


Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr 
            260                 265                 270         


Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr 
        275                 280                 285             


Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro 
    290                 295                 300                 


Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile 
305                 310                 315                 320 


Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser 
                325                 330                 335     


Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val 
            340                 345                 350         


Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn 
        355                 360                 365             


Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro 
    370                 375                 380                 


Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu 
385                 390                 395                 400 


Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys 
                405                 410                 415     


Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn 
            420                 425                 430         


Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn 
        435                 440                 445             


Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His 
    450                 455                 460                 


Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp 
465                 470                 475                 480 


Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe 
                485                 490                 495     


Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu 
            500                 505                 510         


Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His 
        515                 520                 525             


Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe 
    530                 535                 540                 


Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys 
545                 550                 555                 560 


Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu 
                565                 570                 575     


His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser 
            580                 585                 590         


Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys 
        595                 600                 605             


Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys 
    610                 615                 620                 


Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys 
625                 630                 635                 640 


Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu 
                645                 650                 655     


Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser 
            660                 665                 670         


Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu 
        675                 680                 685             


Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr 
    690                 695                 700                 


Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro 
705                 710                 715                 720 


Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe 
                725                 730                 735     


Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu 
            740                 745                 750         


Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala 
        755                 760                 765             


Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr 
    770                 775                 780                 


Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln 
785                 790                 795                 800 


Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met 
                805                 810                 815     


Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu 
            820                 825                 830         


Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala 
        835                 840                 845             


Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe 
    850                 855                 860                 


Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys 
865                 870                 875                 880 


Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala 
                885                 890                 895     


Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser 
            900                 905                 910         


Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile 
        915                 920                 925             


Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe 
    930                 935                 940                 


Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser 
945                 950                 955                 960 


Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr 
                965                 970                 975     


Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu 
            980                 985                 990         


Ala Thr Phe Arg Leu Arg Cys Val  Gln Glu Ala Leu Glu  Val Ile Gln 
        995                 1000                 1005             


Leu Asn  Ile Gln Trp Met Glu  Lys Asn Leu Lys Ser  Leu Thr Trp 
    1010                 1015                 1020             


Trp Leu  
    1025 


<210>  6
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Pro Phe Thr Asn Asp Arg Leu Gln Leu Pro Arg Asn Met Ile 
1               5                   10                  15      


Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys 
            20                  25                  30          


Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro 
        35                  40                  45              


Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu 
    50                  55                  60                  


Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser 
65                  70                  75                  80  


Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg 
                85                  90                  95      


Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val 
            100                 105                 110         


Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile 
        115                 120                 125             


Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys 
    130                 135                 140                 


Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu 
145                 150                 155                 160 


Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg 
                165                 170                 175     


Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly 
            180                 185                 190         


Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile 
        195                 200                 205             


Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala 
    210                 215                 220                 


Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His 
225                 230                 235                 240 


Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn 
                245                 250                 255     


Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr 
            260                 265                 270         


Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr 
        275                 280                 285             


Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro 
    290                 295                 300                 


Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile 
305                 310                 315                 320 


Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser 
                325                 330                 335     


Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val 
            340                 345                 350         


Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn 
        355                 360                 365             


Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro 
    370                 375                 380                 


Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu 
385                 390                 395                 400 


Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys 
                405                 410                 415     


Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn 
            420                 425                 430         


Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn 
        435                 440                 445             


Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His 
    450                 455                 460                 


Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp 
465                 470                 475                 480 


Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe 
                485                 490                 495     


Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu 
            500                 505                 510         


Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His 
        515                 520                 525             


Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe 
    530                 535                 540                 


Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys 
545                 550                 555                 560 


Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu 
                565                 570                 575     


His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser 
            580                 585                 590         


Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys 
        595                 600                 605             


Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys 
    610                 615                 620                 


Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys 
625                 630                 635                 640 


Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu 
                645                 650                 655     


Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser 
            660                 665                 670         


Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu 
        675                 680                 685             


Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr 
    690                 695                 700                 


Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro 
705                 710                 715                 720 


Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe 
                725                 730                 735     


Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu 
            740                 745                 750         


Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala 
        755                 760                 765             


Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr 
    770                 775                 780                 


Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln 
785                 790                 795                 800 


Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met 
                805                 810                 815     


Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu 
            820                 825                 830         


Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala 
        835                 840                 845             


Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe 
    850                 855                 860                 


Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys 
865                 870                 875                 880 


Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala 
                885                 890                 895     


Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser 
            900                 905                 910         


Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile 
        915                 920                 925             


Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe 
    930                 935                 940                 


Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser 
945                 950                 955                 960 


Tyr Thr Val Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr 
                965                 970                 975     


Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu 
            980                 985                 990         


Ala Thr Phe Arg Leu Arg Cys Val  Gln Glu Ala Leu Glu  Val Ile Gln 
        995                 1000                 1005             


Leu Asn  Ile Gln Trp Met Glu  Lys Asn Leu Lys Ser  Leu Thr Trp 
    1010                 1015                 1020             


Trp Leu  
    1025 


<210>  7
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Pro Phe Thr Asn Asp Arg Leu Gln Leu Pro Arg Asn Met Ile 
1               5                   10                  15      


Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys 
            20                  25                  30          


Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro 
        35                  40                  45              


Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu 
    50                  55                  60                  


Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser 
65                  70                  75                  80  


Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg 
                85                  90                  95      


Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val 
            100                 105                 110         


Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile 
        115                 120                 125             


Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys 
    130                 135                 140                 


Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu 
145                 150                 155                 160 


Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg 
                165                 170                 175     


Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly 
            180                 185                 190         


Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile 
        195                 200                 205             


Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala 
    210                 215                 220                 


Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His 
225                 230                 235                 240 


Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn 
                245                 250                 255     


Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr 
            260                 265                 270         


Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr 
        275                 280                 285             


Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro 
    290                 295                 300                 


Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile 
305                 310                 315                 320 


Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser 
                325                 330                 335     


Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val 
            340                 345                 350         


Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn 
        355                 360                 365             


Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro 
    370                 375                 380                 


Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu 
385                 390                 395                 400 


Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys 
                405                 410                 415     


Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn 
            420                 425                 430         


Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn 
        435                 440                 445             


Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His 
    450                 455                 460                 


Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp 
465                 470                 475                 480 


Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe 
                485                 490                 495     


Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu 
            500                 505                 510         


Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His 
        515                 520                 525             


Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe 
    530                 535                 540                 


Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys 
545                 550                 555                 560 


Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu 
                565                 570                 575     


His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser 
            580                 585                 590         


Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys 
        595                 600                 605             


Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys 
    610                 615                 620                 


Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys 
625                 630                 635                 640 


Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu 
                645                 650                 655     


Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser 
            660                 665                 670         


Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu 
        675                 680                 685             


Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr 
    690                 695                 700                 


Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro 
705                 710                 715                 720 


Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe 
                725                 730                 735     


Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu 
            740                 745                 750         


Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Thr Pro Ile Thr Glu Ala 
        755                 760                 765             


Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr 
    770                 775                 780                 


Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln 
785                 790                 795                 800 


Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met 
                805                 810                 815     


Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu 
            820                 825                 830         


Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala 
        835                 840                 845             


Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe 
    850                 855                 860                 


Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys 
865                 870                 875                 880 


Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala 
                885                 890                 895     


Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser 
            900                 905                 910         


Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile 
        915                 920                 925             


Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe 
    930                 935                 940                 


Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser 
945                 950                 955                 960 


Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr 
                965                 970                 975     


Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu 
            980                 985                 990         


Ala Thr Phe Arg Leu Arg Cys Val  Gln Glu Ala Leu Glu  Val Ile Gln 
        995                 1000                 1005             


Leu Asn  Ile Gln Trp Met Glu  Lys Asn Leu Lys Ser  Leu Thr Trp 
    1010                 1015                 1020             


Trp Leu  
    1025 


<210>  8
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ile Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu 
1               5                   10                  15      


Ala Lys Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr 
            20                  25                  30          


Glu Pro Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu 
        35                  40                  45              


Met Glu Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly 
    50                  55                  60                  


Met Ser Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly 
65                  70                  75                  80  


Tyr Arg Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr 
                85                  90                  95      


Met Val Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met 
            100                 105                 110         


Val Ile Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His 
        115                 120                 125             


Lys Lys Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly 
    130                 135                 140                 


Lys Leu Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro 
145                 150                 155                 160 


Leu Arg Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe 
                165                 170                 175     


Arg Gly Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn 
            180                 185                 190         


Ile Ile Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met 
        195                 200                 205             


Ser Ala Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala 
    210                 215                 220                 


Tyr His Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly 
225                 230                 235                 240 


His Asn Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser 
                245                 250                 255     


Tyr Tyr Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys 
            260                 265                 270         


Lys Tyr Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala 
        275                 280                 285             


Phe Pro Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys 
    290                 295                 300                 


Ile Ile Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys 
305                 310                 315                 320 


Ser Ser Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu 
                325                 330                 335     


Ser Val Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met 
            340                 345                 350         


Lys Asn Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala 
        355                 360                 365             


Val Pro Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val 
    370                 375                 380                 


Lys Leu Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu 
385                 390                 395                 400 


Lys Lys Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met 
                405                 410                 415     


Glu Asn Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp 
            420                 425                 430         


Ser Asn Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile 
        435                 440                 445             


Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys 
    450                 455                 460                 


Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu 
465                 470                 475                 480 


Tyr Phe Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp 
                485                 490                 495     


Phe Leu Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser 
            500                 505                 510         


Ser His Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu 
        515                 520                 525             


Met Phe Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met 
    530                 535                 540                 


Leu Lys Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu 
545                 550                 555                 560 


Tyr Leu His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp 
                565                 570                 575     


Asp Ser Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met 
            580                 585                 590         


Met Lys Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln 
        595                 600                 605             


Lys Lys Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn 
    610                 615                 620                 


Met Lys Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile 
625                 630                 635                 640 


Pro Leu Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser 
                645                 650                 655     


Val Ser Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu 
            660                 665                 670         


Val Leu Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val 
        675                 680                 685             


His Tyr Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile 
    690                 695                 700                 


Asn Pro Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn 
705                 710                 715                 720 


Ile Phe Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe 
                725                 730                 735     


Asp Leu Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr 
            740                 745                 750         


Glu Ala Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu 
        755                 760                 765             


Gly Tyr Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu 
    770                 775                 780                 


Leu Gln Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro 
785                 790                 795                 800 


Ser Met Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His 
                805                 810                 815     


Asn Leu Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp 
            820                 825                 830         


Met Ala Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr 
        835                 840                 845             


Val Phe Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu 
    850                 855                 860                 


Gly Lys Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu 
865                 870                 875                 880 


Glu Ala Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met 
                885                 890                 895     


Lys Ser Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe 
            900                 905                 910         


Ile Ile Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp 
        915                 920                 925             


Asp Phe Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu 
    930                 935                 940                 


Gly Ser Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe 
945                 950                 955                 960 


Ser Thr Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln 
                965                 970                 975     


Ser Glu Ala Thr Phe Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val 
            980                 985                 990         


Ile Gln Leu Asn Ile Gln Trp Met  Glu Lys Asn Leu Lys  Ser Leu Thr 
        995                 1000                 1005             


Trp Trp  Leu 
    1010     


<210>  9
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ile Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu 
1               5                   10                  15      


Ala Lys Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr 
            20                  25                  30          


Glu Pro Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu 
        35                  40                  45              


Met Glu Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly 
    50                  55                  60                  


Met Ser Phe Met Asn Arg Ser Pro Gly Leu Arg Asn Ser Ala Thr Gly 
65                  70                  75                  80  


Tyr Arg Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr 
                85                  90                  95      


Met Val Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met 
            100                 105                 110         


Val Ile Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His 
        115                 120                 125             


Lys Lys Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly 
    130                 135                 140                 


Lys Leu Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro 
145                 150                 155                 160 


Leu Arg Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe 
                165                 170                 175     


Arg Gly Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn 
            180                 185                 190         


Ile Ile Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met 
        195                 200                 205             


Ser Ala Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala 
    210                 215                 220                 


Tyr His Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly 
225                 230                 235                 240 


His Asn Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser 
                245                 250                 255     


Tyr Tyr Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys 
            260                 265                 270         


Lys Tyr Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala 
        275                 280                 285             


Phe Pro Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys 
    290                 295                 300                 


Ile Ile Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys 
305                 310                 315                 320 


Ser Ser Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu 
                325                 330                 335     


Ser Val Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met 
            340                 345                 350         


Lys Asn Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala 
        355                 360                 365             


Val Pro Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val 
    370                 375                 380                 


Lys Leu Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu 
385                 390                 395                 400 


Lys Lys Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met 
                405                 410                 415     


Glu Asn Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp 
            420                 425                 430         


Ser Asn Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile 
        435                 440                 445             


Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys 
    450                 455                 460                 


Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu 
465                 470                 475                 480 


Tyr Phe Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp 
                485                 490                 495     


Phe Leu Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser 
            500                 505                 510         


Ser His Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu 
        515                 520                 525             


Met Phe Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met 
    530                 535                 540                 


Leu Lys Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu 
545                 550                 555                 560 


Tyr Leu His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp 
                565                 570                 575     


Asp Ser Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met 
            580                 585                 590         


Met Lys Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln 
        595                 600                 605             


Lys Lys Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn 
    610                 615                 620                 


Met Lys Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile 
625                 630                 635                 640 


Pro Leu Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser 
                645                 650                 655     


Val Ser Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu 
            660                 665                 670         


Val Leu Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val 
        675                 680                 685             


His Tyr Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile 
    690                 695                 700                 


Asn Pro Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn 
705                 710                 715                 720 


Ile Phe Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe 
                725                 730                 735     


Asp Leu Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr 
            740                 745                 750         


Glu Ala Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu 
        755                 760                 765             


Gly Tyr Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu 
    770                 775                 780                 


Leu Gln Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro 
785                 790                 795                 800 


Ser Met Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His 
                805                 810                 815     


Asn Leu Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp 
            820                 825                 830         


Met Ala Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr 
        835                 840                 845             


Val Phe Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu 
    850                 855                 860                 


Gly Lys Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu 
865                 870                 875                 880 


Glu Ala Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met 
                885                 890                 895     


Lys Ser Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe 
            900                 905                 910         


Ile Ile Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp 
        915                 920                 925             


Asp Phe Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu 
    930                 935                 940                 


Gly Ser Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe 
945                 950                 955                 960 


Ser Thr Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln 
                965                 970                 975     


Ser Glu Ala Thr Phe Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val 
            980                 985                 990         


Ile Gln Leu Asn Ile Gln Trp Met  Glu Lys Asn Leu Lys  Ser Leu Thr 
        995                 1000                 1005             


Trp Trp  Leu 
    1010     


<210>  10
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ile Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu 
1               5                   10                  15      


Ala Lys Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr 
            20                  25                  30          


Glu Pro Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu 
        35                  40                  45              


Met Glu Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly 
    50                  55                  60                  


Met Ser Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly 
65                  70                  75                  80  


Tyr Arg Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr 
                85                  90                  95      


Met Val Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met 
            100                 105                 110         


Val Ile Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His 
        115                 120                 125             


Lys Lys Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly 
    130                 135                 140                 


Lys Leu Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro 
145                 150                 155                 160 


Leu Arg Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe 
                165                 170                 175     


Arg Gly Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn 
            180                 185                 190         


Ile Ile Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met 
        195                 200                 205             


Ser Ala Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala 
    210                 215                 220                 


Tyr His Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly 
225                 230                 235                 240 


His Asn Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser 
                245                 250                 255     


Tyr Tyr Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys 
            260                 265                 270         


Lys Tyr Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala 
        275                 280                 285             


Phe Pro Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys 
    290                 295                 300                 


Ile Ile Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys 
305                 310                 315                 320 


Ser Ser Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu 
                325                 330                 335     


Ser Val Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met 
            340                 345                 350         


Lys Asn Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala 
        355                 360                 365             


Val Pro Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val 
    370                 375                 380                 


Lys Leu Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu 
385                 390                 395                 400 


Lys Lys Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met 
                405                 410                 415     


Glu Asn Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp 
            420                 425                 430         


Ser Asn Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile 
        435                 440                 445             


Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys 
    450                 455                 460                 


Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu 
465                 470                 475                 480 


Tyr Phe Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp 
                485                 490                 495     


Phe Leu Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser 
            500                 505                 510         


Ser His Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu 
        515                 520                 525             


Met Phe Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met 
    530                 535                 540                 


Leu Lys Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu 
545                 550                 555                 560 


Tyr Leu His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp 
                565                 570                 575     


Asp Ser Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met 
            580                 585                 590         


Met Lys Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln 
        595                 600                 605             


Lys Lys Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn 
    610                 615                 620                 


Met Lys Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile 
625                 630                 635                 640 


Pro Leu Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser 
                645                 650                 655     


Val Ser Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu 
            660                 665                 670         


Val Leu Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val 
        675                 680                 685             


His Tyr Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile 
    690                 695                 700                 


Asn Pro Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn 
705                 710                 715                 720 


Ile Phe Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe 
                725                 730                 735     


Asp Leu Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr 
            740                 745                 750         


Glu Ala Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu 
        755                 760                 765             


Gly Tyr Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu 
    770                 775                 780                 


Leu Gln Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro 
785                 790                 795                 800 


Ser Met Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His 
                805                 810                 815     


Asn Leu Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp 
            820                 825                 830         


Met Ala Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr 
        835                 840                 845             


Val Phe Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu 
    850                 855                 860                 


Gly Lys Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu 
865                 870                 875                 880 


Glu Ala Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met 
                885                 890                 895     


Lys Ser Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe 
            900                 905                 910         


Ile Ile Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp 
        915                 920                 925             


Asp Phe Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu 
    930                 935                 940                 


Gly Ser Tyr Thr Val Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe 
945                 950                 955                 960 


Ser Thr Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln 
                965                 970                 975     


Ser Glu Ala Thr Phe Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val 
            980                 985                 990         


Ile Gln Leu Asn Ile Gln Trp Met  Glu Lys Asn Leu Lys  Ser Leu Thr 
        995                 1000                 1005             


Trp Trp  Leu 
    1010     


<210>  11
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ile Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu 
1               5                   10                  15      


Ala Lys Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr 
            20                  25                  30          


Glu Pro Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu 
        35                  40                  45              


Met Glu Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly 
    50                  55                  60                  


Met Ser Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly 
65                  70                  75                  80  


Tyr Arg Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr 
                85                  90                  95      


Met Val Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met 
            100                 105                 110         


Val Ile Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His 
        115                 120                 125             


Lys Lys Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly 
    130                 135                 140                 


Lys Leu Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro 
145                 150                 155                 160 


Leu Arg Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe 
                165                 170                 175     


Arg Gly Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn 
            180                 185                 190         


Ile Ile Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met 
        195                 200                 205             


Ser Ala Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala 
    210                 215                 220                 


Tyr His Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly 
225                 230                 235                 240 


His Asn Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser 
                245                 250                 255     


Tyr Tyr Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys 
            260                 265                 270         


Lys Tyr Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala 
        275                 280                 285             


Phe Pro Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys 
    290                 295                 300                 


Ile Ile Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys 
305                 310                 315                 320 


Ser Ser Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu 
                325                 330                 335     


Ser Val Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met 
            340                 345                 350         


Lys Asn Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala 
        355                 360                 365             


Val Pro Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val 
    370                 375                 380                 


Lys Leu Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu 
385                 390                 395                 400 


Lys Lys Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met 
                405                 410                 415     


Glu Asn Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp 
            420                 425                 430         


Ser Asn Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile 
        435                 440                 445             


Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys 
    450                 455                 460                 


Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu 
465                 470                 475                 480 


Tyr Phe Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp 
                485                 490                 495     


Phe Leu Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser 
            500                 505                 510         


Ser His Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu 
        515                 520                 525             


Met Phe Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met 
    530                 535                 540                 


Leu Lys Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu 
545                 550                 555                 560 


Tyr Leu His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp 
                565                 570                 575     


Asp Ser Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met 
            580                 585                 590         


Met Lys Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln 
        595                 600                 605             


Lys Lys Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn 
    610                 615                 620                 


Met Lys Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile 
625                 630                 635                 640 


Pro Leu Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser 
                645                 650                 655     


Val Ser Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu 
            660                 665                 670         


Val Leu Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val 
        675                 680                 685             


His Tyr Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile 
    690                 695                 700                 


Asn Pro Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn 
705                 710                 715                 720 


Ile Phe Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe 
                725                 730                 735     


Asp Leu Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Thr Pro Ile Thr 
            740                 745                 750         


Glu Ala Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu 
        755                 760                 765             


Gly Tyr Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu 
    770                 775                 780                 


Leu Gln Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro 
785                 790                 795                 800 


Ser Met Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His 
                805                 810                 815     


Asn Leu Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp 
            820                 825                 830         


Met Ala Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr 
        835                 840                 845             


Val Phe Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu 
    850                 855                 860                 


Gly Lys Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu 
865                 870                 875                 880 


Glu Ala Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met 
                885                 890                 895     


Lys Ser Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe 
            900                 905                 910         


Ile Ile Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp 
        915                 920                 925             


Asp Phe Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu 
    930                 935                 940                 


Gly Ser Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe 
945                 950                 955                 960 


Ser Thr Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln 
                965                 970                 975     


Ser Glu Ala Thr Phe Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val 
            980                 985                 990         


Ile Gln Leu Asn Ile Gln Trp Met  Glu Lys Asn Leu Lys  Ser Leu Thr 
        995                 1000                 1005             


Trp Trp  Leu 
    1010     


<210>  12
<211>  1006
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys Glu Pro Cys 
1               5                   10                  15      


Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro Arg Gly Ser 
            20                  25                  30          


Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu Glu Asp Glu 
        35                  40                  45              


Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser Phe Met Asn 
    50                  55                  60                  


Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg Gln Ser Pro 
65                  70                  75                  80  


Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val Val Cys Ala 
                85                  90                  95      


Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile Tyr Leu Leu 
            100                 105                 110         


Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys Asn Gln Ser 
        115                 120                 125             


Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu Phe Pro Trp 
    130                 135                 140                 


Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg Tyr Glu Leu 
145                 150                 155                 160 


Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly Ser Val Thr 
                165                 170                 175     


Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile Leu His Ser 
            180                 185                 190         


Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala Val Ser Ser 
        195                 200                 205             


Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His Gly Gln Ile 
    210                 215                 220                 


Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn Tyr Thr Leu 
225                 230                 235                 240 


Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr Gly Phe Tyr 
                245                 250                 255     


Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr Phe Ala Ala 
            260                 265                 270         


Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro Cys Phe Asp 
        275                 280                 285             


Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile Arg Asp Glu 
    290                 295                 300                 


Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser Val Val Leu 
305                 310                 315                 320 


Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val Lys Met Ser 
                325                 330                 335     


Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn Leu Ser Gln 
            340                 345                 350         


Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro Glu Lys Ile 
        355                 360                 365             


Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu Leu Glu Phe 
    370                 375                 380                 


Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys Leu Asp Leu 
385                 390                 395                 400 


Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn Trp Gly Leu 
                405                 410                 415     


Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn Thr Ser Ser 
            420                 425                 430         


Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His Glu Leu Ala 
        435                 440                 445             


His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp Asn Asp Leu 
    450                 455                 460                 


Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe Ser Leu Glu 
465                 470                 475                 480 


Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu Asp Ala Arg 
                485                 490                 495     


Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His Pro Ile Ser 
            500                 505                 510         


Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe Asp Ser Leu 
        515                 520                 525             


Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys Thr Tyr Leu 
    530                 535                 540                 


Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu His Asn His 
545                 550                 555                 560 


Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser Phe Asn Glu 
                565                 570                 575     


Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys Thr Trp Thr 
            580                 585                 590         


Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys Gly Lys Glu 
        595                 600                 605             


Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys Pro Glu Ile 
    610                 615                 620                 


Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu Ser Tyr Val 
625                 630                 635                 640 


Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser Leu Leu Asp 
                645                 650                 655     


Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu Trp Val Lys 
            660                 665                 670         


Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr Ala Asp Asp 
        675                 680                 685             


Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro Tyr Val Leu 
    690                 695                 700                 


Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe Glu Leu Ala 
705                 710                 715                 720 


Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu Ile Asn Tyr 
                725                 730                 735     


Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala Leu Phe Gln 
            740                 745                 750         


Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr Met Asp Leu 
        755                 760                 765             


Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln Asn Gln Ile 
    770                 775                 780                 


Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met Arg Glu Leu 
785                 790                 795                 800 


Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu Gly Asn Cys 
                805                 810                 815     


Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala Ser Asn Gly 
            820                 825                 830         


Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe Lys Val Gly 
        835                 840                 845             


Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys Tyr Ile Ser 
    850                 855                 860                 


Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala Leu Ala Ser 
865                 870                 875                 880 


Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser Ser Leu Asn 
                885                 890                 895     


Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile Arg Thr Val 
            900                 905                 910         


Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe Val Lys Glu 
        915                 920                 925             


Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser Tyr Thr Ile 
    930                 935                 940                 


Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr Lys Thr His 
945                 950                 955                 960 


Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu Ala Thr Phe 
                965                 970                 975     


Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile Gln Leu Asn Ile 
            980                 985                 990         


Gln Trp Met Glu Lys Asn Leu Lys  Ser Leu Thr Trp Trp  Leu 
        995                 1000                 1005     


<210>  13
<211>  1006
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys Glu Pro Cys 
1               5                   10                  15      


Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro Arg Gly Ser 
            20                  25                  30          


Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu Glu Asp Glu 
        35                  40                  45              


Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser Phe Met Asn 
    50                  55                  60                  


Arg Ser Pro Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg Gln Ser Pro 
65                  70                  75                  80  


Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val Val Cys Ala 
                85                  90                  95      


Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile Tyr Leu Leu 
            100                 105                 110         


Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys Asn Gln Ser 
        115                 120                 125             


Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu Phe Pro Trp 
    130                 135                 140                 


Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg Tyr Glu Leu 
145                 150                 155                 160 


Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly Ser Val Thr 
                165                 170                 175     


Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile Leu His Ser 
            180                 185                 190         


Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala Val Ser Ser 
        195                 200                 205             


Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His Gly Gln Ile 
    210                 215                 220                 


Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn Tyr Thr Leu 
225                 230                 235                 240 


Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr Gly Phe Tyr 
                245                 250                 255     


Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr Phe Ala Ala 
            260                 265                 270         


Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro Cys Phe Asp 
        275                 280                 285             


Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile Arg Asp Glu 
    290                 295                 300                 


Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser Val Val Leu 
305                 310                 315                 320 


Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val Lys Met Ser 
                325                 330                 335     


Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn Leu Ser Gln 
            340                 345                 350         


Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro Glu Lys Ile 
        355                 360                 365             


Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu Leu Glu Phe 
    370                 375                 380                 


Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys Leu Asp Leu 
385                 390                 395                 400 


Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn Trp Gly Leu 
                405                 410                 415     


Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn Thr Ser Ser 
            420                 425                 430         


Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His Glu Leu Ala 
        435                 440                 445             


His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp Asn Asp Leu 
    450                 455                 460                 


Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe Ser Leu Glu 
465                 470                 475                 480 


Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu Asp Ala Arg 
                485                 490                 495     


Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His Pro Ile Ser 
            500                 505                 510         


Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe Asp Ser Leu 
        515                 520                 525             


Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys Thr Tyr Leu 
    530                 535                 540                 


Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu His Asn His 
545                 550                 555                 560 


Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser Phe Asn Glu 
                565                 570                 575     


Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys Thr Trp Thr 
            580                 585                 590         


Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys Gly Lys Glu 
        595                 600                 605             


Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys Pro Glu Ile 
    610                 615                 620                 


Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu Ser Tyr Val 
625                 630                 635                 640 


Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser Leu Leu Asp 
                645                 650                 655     


Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu Trp Val Lys 
            660                 665                 670         


Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr Ala Asp Asp 
        675                 680                 685             


Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro Tyr Val Leu 
    690                 695                 700                 


Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe Glu Leu Ala 
705                 710                 715                 720 


Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu Ile Asn Tyr 
                725                 730                 735     


Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala Leu Phe Gln 
            740                 745                 750         


Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr Met Asp Leu 
        755                 760                 765             


Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln Asn Gln Ile 
    770                 775                 780                 


Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met Arg Glu Leu 
785                 790                 795                 800 


Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu Gly Asn Cys 
                805                 810                 815     


Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala Ser Asn Gly 
            820                 825                 830         


Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe Lys Val Gly 
        835                 840                 845             


Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys Tyr Ile Ser 
    850                 855                 860                 


Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala Leu Ala Ser 
865                 870                 875                 880 


Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser Ser Leu Asn 
                885                 890                 895     


Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile Arg Thr Val 
            900                 905                 910         


Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe Val Lys Glu 
        915                 920                 925             


Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser Tyr Thr Ile 
    930                 935                 940                 


Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr Lys Thr His 
945                 950                 955                 960 


Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu Ala Thr Phe 
                965                 970                 975     


Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile Gln Leu Asn Ile 
            980                 985                 990         


Gln Trp Met Glu Lys Asn Leu Lys  Ser Leu Thr Trp Trp  Leu 
        995                 1000                 1005     


<210>  14
<211>  1006
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys Glu Pro Cys 
1               5                   10                  15      


Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro Arg Gly Ser 
            20                  25                  30          


Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu Glu Asp Glu 
        35                  40                  45              


Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser Phe Met Asn 
    50                  55                  60                  


Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg Gln Ser Pro 
65                  70                  75                  80  


Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val Val Cys Ala 
                85                  90                  95      


Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile Tyr Leu Leu 
            100                 105                 110         


Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys Asn Gln Ser 
        115                 120                 125             


Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu Phe Pro Trp 
    130                 135                 140                 


Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg Tyr Glu Leu 
145                 150                 155                 160 


Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly Ser Val Thr 
                165                 170                 175     


Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile Leu His Ser 
            180                 185                 190         


Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala Val Ser Ser 
        195                 200                 205             


Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His Gly Gln Ile 
    210                 215                 220                 


Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn Tyr Thr Leu 
225                 230                 235                 240 


Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr Gly Phe Tyr 
                245                 250                 255     


Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr Phe Ala Ala 
            260                 265                 270         


Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro Cys Phe Asp 
        275                 280                 285             


Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile Arg Asp Glu 
    290                 295                 300                 


Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser Val Val Leu 
305                 310                 315                 320 


Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val Lys Met Ser 
                325                 330                 335     


Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn Leu Ser Gln 
            340                 345                 350         


Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro Glu Lys Ile 
        355                 360                 365             


Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu Leu Glu Phe 
    370                 375                 380                 


Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys Leu Asp Leu 
385                 390                 395                 400 


Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn Trp Gly Leu 
                405                 410                 415     


Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn Thr Ser Ser 
            420                 425                 430         


Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His Glu Leu Ala 
        435                 440                 445             


His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp Asn Asp Leu 
    450                 455                 460                 


Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe Ser Leu Glu 
465                 470                 475                 480 


Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu Asp Ala Arg 
                485                 490                 495     


Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His Pro Ile Ser 
            500                 505                 510         


Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe Asp Ser Leu 
        515                 520                 525             


Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys Thr Tyr Leu 
    530                 535                 540                 


Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu His Asn His 
545                 550                 555                 560 


Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser Phe Asn Glu 
                565                 570                 575     


Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys Thr Trp Thr 
            580                 585                 590         


Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys Gly Lys Glu 
        595                 600                 605             


Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys Pro Glu Ile 
    610                 615                 620                 


Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu Ser Tyr Val 
625                 630                 635                 640 


Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser Leu Leu Asp 
                645                 650                 655     


Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu Trp Val Lys 
            660                 665                 670         


Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr Ala Asp Asp 
        675                 680                 685             


Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro Tyr Val Leu 
    690                 695                 700                 


Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe Glu Leu Ala 
705                 710                 715                 720 


Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu Ile Asn Tyr 
                725                 730                 735     


Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala Leu Phe Gln 
            740                 745                 750         


Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr Met Asp Leu 
        755                 760                 765             


Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln Asn Gln Ile 
    770                 775                 780                 


Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met Arg Glu Leu 
785                 790                 795                 800 


Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu Gly Asn Cys 
                805                 810                 815     


Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala Ser Asn Gly 
            820                 825                 830         


Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe Lys Val Gly 
        835                 840                 845             


Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys Tyr Ile Ser 
    850                 855                 860                 


Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala Leu Ala Ser 
865                 870                 875                 880 


Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser Ser Leu Asn 
                885                 890                 895     


Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile Arg Thr Val 
            900                 905                 910         


Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe Val Lys Glu 
        915                 920                 925             


Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser Tyr Thr Val 
    930                 935                 940                 


Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr Lys Thr His 
945                 950                 955                 960 


Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu Ala Thr Phe 
                965                 970                 975     


Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile Gln Leu Asn Ile 
            980                 985                 990         


Gln Trp Met Glu Lys Asn Leu Lys  Ser Leu Thr Trp Trp  Leu 
        995                 1000                 1005     


<210>  15
<211>  1006
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys Glu Pro Cys 
1               5                   10                  15      


Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro Arg Gly Ser 
            20                  25                  30          


Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu Glu Asp Glu 
        35                  40                  45              


Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser Phe Met Asn 
    50                  55                  60                  


Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg Gln Ser Pro 
65                  70                  75                  80  


Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val Val Cys Ala 
                85                  90                  95      


Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile Tyr Leu Leu 
            100                 105                 110         


Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys Asn Gln Ser 
        115                 120                 125             


Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu Phe Pro Trp 
    130                 135                 140                 


Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg Tyr Glu Leu 
145                 150                 155                 160 


Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly Ser Val Thr 
                165                 170                 175     


Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile Leu His Ser 
            180                 185                 190         


Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala Val Ser Ser 
        195                 200                 205             


Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His Gly Gln Ile 
    210                 215                 220                 


Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn Tyr Thr Leu 
225                 230                 235                 240 


Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr Gly Phe Tyr 
                245                 250                 255     


Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr Phe Ala Ala 
            260                 265                 270         


Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro Cys Phe Asp 
        275                 280                 285             


Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile Arg Asp Glu 
    290                 295                 300                 


Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser Val Val Leu 
305                 310                 315                 320 


Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val Lys Met Ser 
                325                 330                 335     


Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn Leu Ser Gln 
            340                 345                 350         


Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro Glu Lys Ile 
        355                 360                 365             


Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu Leu Glu Phe 
    370                 375                 380                 


Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys Leu Asp Leu 
385                 390                 395                 400 


Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn Trp Gly Leu 
                405                 410                 415     


Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn Thr Ser Ser 
            420                 425                 430         


Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His Glu Leu Ala 
        435                 440                 445             


His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp Asn Asp Leu 
    450                 455                 460                 


Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe Ser Leu Glu 
465                 470                 475                 480 


Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu Asp Ala Arg 
                485                 490                 495     


Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His Pro Ile Ser 
            500                 505                 510         


Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe Asp Ser Leu 
        515                 520                 525             


Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys Thr Tyr Leu 
    530                 535                 540                 


Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu His Asn His 
545                 550                 555                 560 


Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser Phe Asn Glu 
                565                 570                 575     


Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys Thr Trp Thr 
            580                 585                 590         


Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys Gly Lys Glu 
        595                 600                 605             


Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys Pro Glu Ile 
    610                 615                 620                 


Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu Ser Tyr Val 
625                 630                 635                 640 


Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser Leu Leu Asp 
                645                 650                 655     


Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu Trp Val Lys 
            660                 665                 670         


Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr Ala Asp Asp 
        675                 680                 685             


Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro Tyr Val Leu 
    690                 695                 700                 


Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe Glu Leu Ala 
705                 710                 715                 720 


Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu Ile Asn Tyr 
                725                 730                 735     


Leu Gly Asn Glu Asn His Thr Thr Pro Ile Thr Glu Ala Leu Phe Gln 
            740                 745                 750         


Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr Met Asp Leu 
        755                 760                 765             


Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln Asn Gln Ile 
    770                 775                 780                 


Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met Arg Glu Leu 
785                 790                 795                 800 


Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu Gly Asn Cys 
                805                 810                 815     


Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala Ser Asn Gly 
            820                 825                 830         


Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe Lys Val Gly 
        835                 840                 845             


Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys Tyr Ile Ser 
    850                 855                 860                 


Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala Leu Ala Ser 
865                 870                 875                 880 


Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser Ser Leu Asn 
                885                 890                 895     


Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile Arg Thr Val 
            900                 905                 910         


Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe Val Lys Glu 
        915                 920                 925             


Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser Tyr Thr Ile 
    930                 935                 940                 


Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr Lys Thr His 
945                 950                 955                 960 


Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu Ala Thr Phe 
                965                 970                 975     


Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile Gln Leu Asn Ile 
            980                 985                 990         


Gln Trp Met Glu Lys Asn Leu Lys  Ser Leu Thr Trp Trp  Leu 
        995                 1000                 1005     


<210>  16
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  16

Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys Asn Gln Ser 
1               5                   10                  15      


Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu Phe Pro Trp 
            20                  25                  30          


Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg Tyr Glu Leu 
        35                  40                  45              


Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly Ser Val Thr 
    50                  55                  60                  


Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile Leu His Ser 
65                  70                  75                  80  


Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala Val Ser Ser 
                85                  90                  95      


Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His Gly Gln Ile 
            100                 105                 110         


Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn Tyr Thr Leu 
        115                 120                 125             


Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr Gly Phe Tyr 
    130                 135                 140                 


Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr Phe Ala Ala 
145                 150                 155                 160 


Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro Cys Phe Asp 
                165                 170                 175     


Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile Arg Asp Glu 
            180                 185                 190         


Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser Val Val Leu 
        195                 200                 205             


Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val Lys Met Ser 
    210                 215                 220                 


Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn Leu Ser Gln 
225                 230                 235                 240 


Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro Glu Lys Ile 
                245                 250                 255     


Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu Leu Glu Phe 
            260                 265                 270         


Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys Leu Asp Leu 
        275                 280                 285             


Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn Trp Gly Leu 
    290                 295                 300                 


Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn Thr Ser Ser 
305                 310                 315                 320 


Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His Glu Leu Ala 
                325                 330                 335     


His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp Asn Asp Leu 
            340                 345                 350         


Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe Ser Leu Glu 
        355                 360                 365             


Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu Asp Ala Arg 
    370                 375                 380                 


Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His Pro Ile Ser 
385                 390                 395                 400 


Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe Asp Ser Leu 
                405                 410                 415     


Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys Thr Tyr Leu 
            420                 425                 430         


Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu His Asn His 
        435                 440                 445             


Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser Phe Asn Glu 
    450                 455                 460                 


Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys Thr Trp Thr 
465                 470                 475                 480 


Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys Gly Lys Glu 
                485                 490                 495     


Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys Pro Glu Ile 
            500                 505                 510         


Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu Ser Tyr Val 
        515                 520                 525             


Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser Leu Leu Asp 
    530                 535                 540                 


Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu Trp Val Lys 
545                 550                 555                 560 


Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr Ala Asp Asp 
                565                 570                 575     


Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro Tyr Val Leu 
            580                 585                 590         


Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe Glu Leu Ala 
        595                 600                 605             


Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu Ile Asn Tyr 
    610                 615                 620                 


Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala Leu Phe Gln 
625                 630                 635                 640 


Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr Met Asp Leu 
                645                 650                 655     


Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln Asn Gln Ile 
            660                 665                 670         


Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met Arg Glu Leu 
        675                 680                 685             


Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu Gly Asn Cys 
    690                 695                 700                 


Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala Ser Asn Gly 
705                 710                 715                 720 


Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe Lys Val Gly 
                725                 730                 735     


Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys Tyr Ile Ser 
            740                 745                 750         


Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala Leu Ala Ser 
        755                 760                 765             


Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser Ser Leu Asn 
    770                 775                 780                 


Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile Arg Thr Val 
785                 790                 795                 800 


Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe Val Lys Glu 
                805                 810                 815     


Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser Tyr Thr Ile 
            820                 825                 830         


Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr Lys Thr His 
        835                 840                 845             


Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu Ala Thr Phe 
    850                 855                 860                 


Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile Gln Leu Asn Ile 
865                 870                 875                 880 


Gln Trp Met Glu Lys Asn Leu Lys Ser Leu Thr Trp Trp Leu 
                885                 890                 


<210>  17
<211>  951
<212>  PRT
<213>  Homo sapiens

<400>  17

Lys Leu Leu Gly Met Ser Phe Met Asn Arg Ser Ser Gly Leu Arg Asn 
1               5                   10                  15      


Ser Ala Thr Gly Tyr Arg Gln Ser Pro Asp Gly Ala Cys Ser Val Pro 
            20                  25                  30          


Ser Ala Arg Thr Met Val Val Cys Ala Phe Val Ile Val Val Ala Val 
        35                  40                  45              


Ser Val Ile Met Val Ile Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys 
    50                  55                  60                  


Glu Gly Cys His Lys Lys Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe 
65                  70                  75                  80  


Ala Thr Asn Gly Lys Leu Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr 
                85                  90                  95      


Ala Val Val Pro Leu Arg Tyr Glu Leu Ser Leu His Pro Asn Leu Thr 
            100                 105                 110         


Ser Met Thr Phe Arg Gly Ser Val Thr Ile Ser Val Gln Ala Leu Gln 
        115                 120                 125             


Val Thr Trp Asn Ile Ile Leu His Ser Thr Gly His Asn Ile Ser Arg 
    130                 135                 140                 


Val Thr Phe Met Ser Ala Val Ser Ser Gln Glu Lys Gln Ala Glu Ile 
145                 150                 155                 160 


Leu Glu Tyr Ala Tyr His Gly Gln Ile Ala Ile Val Ala Pro Glu Ala 
                165                 170                 175     


Leu Leu Ala Gly His Asn Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn 
            180                 185                 190         


Ile Ser Ser Ser Tyr Tyr Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu 
        195                 200                 205             


Ser Asn Glu Lys Lys Tyr Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala 
    210                 215                 220                 


Ala Arg Ser Ala Phe Pro Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr 
225                 230                 235                 240 


Phe Ile Ile Lys Ile Ile Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn 
                245                 250                 255     


Met Pro Lys Lys Ser Ser Val Val Leu Asp Asp Gly Leu Val Gln Asp 
            260                 265                 270         


Glu Phe Ser Glu Ser Val Lys Met Ser Thr Tyr Leu Val Ala Phe Ile 
        275                 280                 285             


Val Gly Glu Met Lys Asn Leu Ser Gln Asp Val Asn Gly Thr Leu Val 
    290                 295                 300                 


Ser Ile Tyr Ala Val Pro Glu Lys Ile Gly Gln Val His Tyr Ala Leu 
305                 310                 315                 320 


Glu Thr Thr Val Lys Leu Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile 
                325                 330                 335     


Gln Tyr Pro Leu Lys Lys Leu Asp Leu Val Ala Ile Pro Asp Phe Glu 
            340                 345                 350         


Ala Gly Ala Met Glu Asn Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr 
        355                 360                 365             


Leu Leu Tyr Asp Ser Asn Thr Ser Ser Met Ala Asp Arg Lys Leu Val 
    370                 375                 380                 


Thr Lys Ile Ile Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu 
385                 390                 395                 400 


Val Thr Met Lys Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala 
                405                 410                 415     


Thr Phe Met Glu Tyr Phe Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser 
            420                 425                 430         


Ser Tyr Glu Asp Phe Leu Asp Ala Arg Phe Lys Thr Met Lys Lys Asp 
        435                 440                 445             


Ser Leu Asn Ser Ser His Pro Ile Ser Ser Ser Val Gln Ser Ser Glu 
    450                 455                 460                 


Gln Ile Glu Glu Met Phe Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser 
465                 470                 475                 480 


Leu Leu Leu Met Leu Lys Thr Tyr Leu Ser Glu Asp Val Phe Gln His 
                485                 490                 495     


Ala Val Val Leu Tyr Leu His Asn His Ser Tyr Ala Ser Ile Gln Ser 
            500                 505                 510         


Asp Asp Leu Trp Asp Ser Phe Asn Glu Val Thr Asn Gln Thr Leu Asp 
        515                 520                 525             


Val Lys Arg Met Met Lys Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu 
    530                 535                 540                 


Val Thr Val Gln Lys Lys Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg 
545                 550                 555                 560 


Phe Phe Leu Asn Met Lys Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr 
                565                 570                 575     


Leu Trp His Ile Pro Leu Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser 
            580                 585                 590         


Lys Tyr Gln Ser Val Ser Leu Leu Asp Lys Lys Ser Gly Val Ile Asn 
        595                 600                 605             


Leu Thr Glu Glu Val Leu Trp Val Lys Val Asn Ile Asn Met Asn Gly 
    610                 615                 620                 


Tyr Tyr Ile Val His Tyr Ala Asp Asp Asp Trp Glu Ala Leu Ile His 
625                 630                 635                 640 


Gln Leu Lys Ile Asn Pro Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn 
                645                 650                 655     


Leu Ile Asn Asn Ile Phe Glu Leu Ala Gly Leu Gly Lys Val Pro Leu 
            660                 665                 670         


Lys Arg Ala Phe Asp Leu Ile Asn Tyr Leu Gly Asn Glu Asn His Thr 
        675                 680                 685             


Ala Pro Ile Thr Glu Ala Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu 
    690                 695                 700                 


Leu Glu Lys Leu Gly Tyr Met Asp Leu Ala Ser Arg Leu Val Thr Arg 
705                 710                 715                 720 


Val Phe Lys Leu Leu Gln Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp 
                725                 730                 735     


Glu Gly Thr Pro Ser Met Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe 
            740                 745                 750         


Ala Cys Thr His Asn Leu Gly Asn Cys Ser Thr Thr Ala Met Lys Leu 
        755                 760                 765             


Phe Asp Asp Trp Met Ala Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp 
    770                 775                 780                 


Val Met Thr Thr Val Phe Lys Val Gly Ala Lys Thr Asp Lys Gly Trp 
785                 790                 795                 800 


Ser Phe Leu Leu Gly Lys Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys 
                805                 810                 815     


Asn Lys Ile Leu Glu Ala Leu Ala Ser Ser Glu Asp Val Arg Lys Leu 
            820                 825                 830         


Tyr Trp Leu Met Lys Ser Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln 
        835                 840                 845             


Lys Leu Ser Phe Ile Ile Arg Thr Val Gly Arg His Phe Pro Gly His 
    850                 855                 860                 


Leu Leu Ala Trp Asp Phe Val Lys Glu Asn Trp Asn Lys Leu Val Gln 
865                 870                 875                 880 


Lys Phe Pro Leu Gly Ser Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser 
                885                 890                 895     


Thr Tyr Leu Phe Ser Thr Lys Thr His Leu Ser Glu Val Gln Ala Phe 
            900                 905                 910         


Phe Glu Asn Gln Ser Glu Ala Thr Phe Arg Leu Arg Cys Val Gln Glu 
        915                 920                 925             


Ala Leu Glu Val Ile Gln Leu Asn Ile Gln Trp Met Glu Lys Asn Leu 
    930                 935                 940                 


Lys Ser Leu Thr Trp Trp Leu 
945                 950     


<210>  18
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  18

Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys Asn Gln Ser 
1               5                   10                  15      


Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu Phe Pro Trp 
            20                  25                  30          


Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg Tyr Glu Leu 
        35                  40                  45              


Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly Ser Val Thr 
    50                  55                  60                  


Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile Leu His Ser 
65                  70                  75                  80  


Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala Val Ser Ser 
                85                  90                  95      


Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His Gly Gln Ile 
            100                 105                 110         


Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn Tyr Thr Leu 
        115                 120                 125             


Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr Gly Phe Tyr 
    130                 135                 140                 


Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr Phe Ala Ala 
145                 150                 155                 160 


Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro Cys Phe Asp 
                165                 170                 175     


Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile Arg Asp Glu 
            180                 185                 190         


Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser Val Val Leu 
        195                 200                 205             


Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val Lys Met Ser 
    210                 215                 220                 


Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn Leu Ser Gln 
225                 230                 235                 240 


Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro Glu Lys Ile 
                245                 250                 255     


Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu Leu Glu Phe 
            260                 265                 270         


Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys Leu Asp Leu 
        275                 280                 285             


Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn Trp Gly Leu 
    290                 295                 300                 


Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn Thr Ser Ser 
305                 310                 315                 320 


Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His Glu Leu Ala 
                325                 330                 335     


His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp Asn Asp Leu 
            340                 345                 350         


Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe Ser Leu Glu 
        355                 360                 365             


Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu Asp Ala Arg 
    370                 375                 380                 


Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His Pro Ile Ser 
385                 390                 395                 400 


Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe Asp Ser Leu 
                405                 410                 415     


Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys Thr Tyr Leu 
            420                 425                 430         


Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu His Asn His 
        435                 440                 445             


Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser Phe Asn Glu 
    450                 455                 460                 


Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys Thr Trp Thr 
465                 470                 475                 480 


Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys Gly Lys Glu 
                485                 490                 495     


Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys Pro Glu Ile 
            500                 505                 510         


Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu Ser Tyr Val 
        515                 520                 525             


Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser Leu Leu Asp 
    530                 535                 540                 


Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu Trp Val Lys 
545                 550                 555                 560 


Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr Ala Asp Asp 
                565                 570                 575     


Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro Tyr Val Leu 
            580                 585                 590         


Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe Glu Leu Ala 
        595                 600                 605             


Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu Ile Asn Tyr 
    610                 615                 620                 


Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala Leu Phe Gln 
625                 630                 635                 640 


Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr Met Asp Leu 
                645                 650                 655     


Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln Asn Gln Ile 
            660                 665                 670         


Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met Arg Glu Leu 
        675                 680                 685             


Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu Gly Asn Cys 
    690                 695                 700                 


Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala Ser Asn Gly 
705                 710                 715                 720 


Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe Lys Val Gly 
                725                 730                 735     


Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys Tyr Ile Ser 
            740                 745                 750         


Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala Leu Ala Ser 
        755                 760                 765             


Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser Ser Leu Asn 
    770                 775                 780                 


Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile Arg Thr Val 
785                 790                 795                 800 


Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe Val Lys Glu 
                805                 810                 815     


Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser Tyr Thr Ile 
            820                 825                 830         


Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr Lys Thr His 
        835                 840                 845             


Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu Ala Thr Phe 
    850                 855                 860                 


Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile Gln Leu Asn Ile 
865                 870                 875                 880 


Gln Trp Met Glu Lys Asn Leu Lys Ser Leu Thr Trp Trp Leu 
                885                 890                 


<210>  19
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  19

Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys Asn Gln Ser 
1               5                   10                  15      


Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu Phe Pro Trp 
            20                  25                  30          


Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg Tyr Glu Leu 
        35                  40                  45              


Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly Ser Val Thr 
    50                  55                  60                  


Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile Leu His Ser 
65                  70                  75                  80  


Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala Val Ser Ser 
                85                  90                  95      


Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His Gly Gln Ile 
            100                 105                 110         


Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn Tyr Thr Leu 
        115                 120                 125             


Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr Gly Phe Tyr 
    130                 135                 140                 


Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr Phe Ala Ala 
145                 150                 155                 160 


Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro Cys Phe Asp 
                165                 170                 175     


Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile Arg Asp Glu 
            180                 185                 190         


Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser Val Val Leu 
        195                 200                 205             


Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val Lys Met Ser 
    210                 215                 220                 


Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn Leu Ser Gln 
225                 230                 235                 240 


Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro Glu Lys Ile 
                245                 250                 255     


Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu Leu Glu Phe 
            260                 265                 270         


Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys Leu Asp Leu 
        275                 280                 285             


Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn Trp Gly Leu 
    290                 295                 300                 


Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn Thr Ser Ser 
305                 310                 315                 320 


Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His Glu Leu Ala 
                325                 330                 335     


His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp Asn Asp Leu 
            340                 345                 350         


Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe Ser Leu Glu 
        355                 360                 365             


Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu Asp Ala Arg 
    370                 375                 380                 


Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His Pro Ile Ser 
385                 390                 395                 400 


Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe Asp Ser Leu 
                405                 410                 415     


Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys Thr Tyr Leu 
            420                 425                 430         


Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu His Asn His 
        435                 440                 445             


Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser Phe Asn Glu 
    450                 455                 460                 


Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys Thr Trp Thr 
465                 470                 475                 480 


Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys Gly Lys Glu 
                485                 490                 495     


Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys Pro Glu Ile 
            500                 505                 510         


Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu Ser Tyr Val 
        515                 520                 525             


Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser Leu Leu Asp 
    530                 535                 540                 


Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu Trp Val Lys 
545                 550                 555                 560 


Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr Ala Asp Asp 
                565                 570                 575     


Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro Tyr Val Leu 
            580                 585                 590         


Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe Glu Leu Ala 
        595                 600                 605             


Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu Ile Asn Tyr 
    610                 615                 620                 


Leu Gly Asn Glu Asn His Thr Thr Pro Ile Thr Glu Ala Leu Phe Gln 
625                 630                 635                 640 


Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr Met Asp Leu 
                645                 650                 655     


Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln Asn Gln Ile 
            660                 665                 670         


Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met Arg Glu Leu 
        675                 680                 685             


Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu Gly Asn Cys 
    690                 695                 700                 


Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala Ser Asn Gly 
705                 710                 715                 720 


Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe Lys Val Gly 
                725                 730                 735     


Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys Tyr Ile Ser 
            740                 745                 750         


Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala Leu Ala Ser 
        755                 760                 765             


Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser Ser Leu Asn 
    770                 775                 780                 


Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile Arg Thr Val 
785                 790                 795                 800 


Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe Val Lys Glu 
                805                 810                 815     


Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser Tyr Thr Ile 
            820                 825                 830         


Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr Lys Thr His 
        835                 840                 845             


Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu Ala Thr Phe 
    850                 855                 860                 


Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile Gln Leu Asn Ile 
865                 870                 875                 880 


Gln Trp Met Glu Lys Asn Leu Lys Ser Leu Thr Trp Trp Leu 
                885                 890                 


<210>  20
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  20

Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys Asn Gln Ser 
1               5                   10                  15      


Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu Phe Pro Trp 
            20                  25                  30          


Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg Tyr Glu Leu 
        35                  40                  45              


Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly Ser Val Thr 
    50                  55                  60                  


Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile Leu His Ser 
65                  70                  75                  80  


Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala Val Ser Ser 
                85                  90                  95      


Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His Gly Gln Ile 
            100                 105                 110         


Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn Tyr Thr Leu 
        115                 120                 125             


Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr Gly Phe Tyr 
    130                 135                 140                 


Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr Phe Ala Ala 
145                 150                 155                 160 


Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro Cys Phe Asp 
                165                 170                 175     


Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile Arg Asp Glu 
            180                 185                 190         


Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser Val Val Leu 
        195                 200                 205             


Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val Lys Met Ser 
    210                 215                 220                 


Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn Leu Ser Gln 
225                 230                 235                 240 


Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro Glu Lys Ile 
                245                 250                 255     


Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu Leu Glu Phe 
            260                 265                 270         


Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys Leu Asp Leu 
        275                 280                 285             


Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn Trp Gly Leu 
    290                 295                 300                 


Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn Thr Ser Ser 
305                 310                 315                 320 


Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His Glu Leu Ala 
                325                 330                 335     


His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp Asn Asp Leu 
            340                 345                 350         


Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe Ser Leu Glu 
        355                 360                 365             


Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu Asp Ala Arg 
    370                 375                 380                 


Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His Pro Ile Ser 
385                 390                 395                 400 


Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe Asp Ser Leu 
                405                 410                 415     


Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys Thr Tyr Leu 
            420                 425                 430         


Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu His Asn His 
        435                 440                 445             


Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser Phe Asn Glu 
    450                 455                 460                 


Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys Thr Trp Thr 
465                 470                 475                 480 


Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys Gly Lys Glu 
                485                 490                 495     


Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys Pro Glu Ile 
            500                 505                 510         


Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu Ser Tyr Val 
        515                 520                 525             


Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser Leu Leu Asp 
    530                 535                 540                 


Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu Trp Val Lys 
545                 550                 555                 560 


Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr Ala Asp Asp 
                565                 570                 575     


Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro Tyr Val Leu 
            580                 585                 590         


Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe Glu Leu Ala 
        595                 600                 605             


Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu Ile Asn Tyr 
    610                 615                 620                 


Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala Leu Phe Gln 
625                 630                 635                 640 


Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr Met Asp Leu 
                645                 650                 655     


Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln Asn Gln Ile 
            660                 665                 670         


Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met Arg Glu Leu 
        675                 680                 685             


Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu Gly Asn Cys 
    690                 695                 700                 


Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala Ser Asn Gly 
705                 710                 715                 720 


Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe Lys Val Gly 
                725                 730                 735     


Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys Tyr Ile Ser 
            740                 745                 750         


Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala Leu Ala Ser 
        755                 760                 765             


Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser Ser Leu Asn 
    770                 775                 780                 


Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile Arg Thr Val 
785                 790                 795                 800 


Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe Val Lys Glu 
                805                 810                 815     


Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser Tyr Thr Val 
            820                 825                 830         


Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr Lys Thr His 
        835                 840                 845             


Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu Ala Thr Phe 
    850                 855                 860                 


Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile Gln Leu Asn Ile 
865                 870                 875                 880 


Gln Trp Met Glu Lys Asn Leu Lys Ser Leu Thr Trp Trp Leu 
                885                 890                 


<210>  21
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  21

Val Tyr Ile His Pro Phe 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide driv de l'angiotensine IV


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa=Val, beta2 homo Val, beta3 homo Val, Leu, beta2 homo leu, 
       beta3 homo Leu, Ile, beta2 homo Ile, beta3 homo Ile, Nlel, beta2 
       homo Nle, beta3 homo Nle, Tle, beta2 homo Tlel, beta3 homo Tle, 
       Cle, beta2 homo Cle ou beta3 homo Cle,

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Tyr, beta2 homo Tyr ou beta3 homo Tyr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa=Leu, beta2 homo leu, beta3 homo Leu, Ile, beta2 homo Ile, 
       beta3 homo Ile, Nlel, beta2 homo Nle, beta3 homo Nle, Tle, beta2 
       homo Tlel, beta3 homo Tle, Cle, beta2 homo Cle ou beta3 homo Cle,

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Pro, beta2 homo Pro ou beta3 homo Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = Phe, beta2 homo Phe ou beta3 homo Phe

<400>  22

Xaa Xaa Xaa His Xaa Xaa 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide driv de l'angiotensine IV


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<400>  23

Xaa Tyr Ile His Pro Phe 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide driv de l'angiotensine IV


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = beta2homo Val

<400>  24

Xaa Tyr Ile His Pro Phe 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide driv de l'angiotensine IV


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = beta2homo Val

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = beta3homo Phe

<400>  25

Xaa Tyr Ile His Pro Xaa 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide driv de l'angiotensine IV


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = beta2 homo Leu

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = beta3 homo Phe

<400>  26

Xaa Tyr Ile His Pro Xaa 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide driv de l'angiotensine IV


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = beta2 homo proline

<400>  27

Val Tyr Ile His Xaa Phe 
1               5       


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide driv de l'angiotensine IV


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa= beta2 homo val

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa= aba-Gly

<400>  28

Xaa Tyr Ile Xaa Phe 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide driv de l'angiotensine IV


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa= beta2 homo val

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa= Aia-Gly

<400>  29

Xaa Tyr Ile Xaa Phe 
1               5   


