                         SEQUENCE LISTING

<110>  Medizinische Hochschule Hannover
       Axel, Schambach, Dr.
       Christopher, Baum, Prof.  Dr.
       Julia, Srth
 
<120>  ASLV Vektorsystem

<130>  M1013PCT

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  229
<212>  DNA
<213>  Avian sarcoma virus


<220>
<221>  misc_feature
<222>  (1)..(229)
<223>  Seq.-ID Nr. 1: 3-U3-Region Wildtyp ASLV

<400>  1
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

ccgcattgca gagatattgt atttaagtgc ctagctcgat acaataaac                  229


<210>  2
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Seq.-ID Nr. 2: U3-Region mit Deletion"

<400>  2
aatgtagtct tatgcaatac tcttgtacgt agagatattg tatttaagtg cctagctcga       60

tacaataaac                                                              70


<210>  3
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Seq.-ID Nr. 3: U3-Region mit Deletion"

<400>  3
aatgtagtct tatgcaatac tcttgtacgt agagatattg tgtctaagtg cctagctcga       60

tacaataaac                                                              70


<210>  4
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Seq.-ID Nr. 4: U3-Region mit Deletion"

<400>  4
aatgtagtct tatgcaatac tcttgtacgt agtgcctagc tcgatacaat aaac             54


<210>  5
<211>  5704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Seq.-ID Nr. 5: viraler Vektor mit deletierter U3-Region"


<220>
<221>  enhancer
<222>  (452)..(684)
<223>  SV40 enhancer

<220>
<221>  promoter
<222>  (693)..(921)
<223>  RSV Promotor

<220>
<221>  misc_feature
<222>  (922)..(942)
<223>  5- LTR: R-Region

<220>
<221>  misc_feature
<222>  (943)..(1022)
<223>  5- LTR: U5-Region

<220>
<221>  PBS
<222>  (1023)..(1041)
<223>  Primer Bindestelle

<220>
<221>  promoter
<222>  (1293)..(1684)
<223>  Interner Promotor der Expressionskassette: SFFV

<220>
<221>  CDS
<222>  (1764)..(2483)
<223>  EGFP: kodierende Sequenz fr eGFP

<220>
<221>  misc_feature
<222>  (2522)..(3124)
<223>  PRE der Expressionskassette

<220>
<221>  misc_feature
<222>  (3282)..(3351)
<223>  3-U3: U3-Region mit Deletion

<220>
<221>  misc_feature
<222>  (3352)..(3372)
<223>  3- R-Region

<220>
<221>  misc_feature
<222>  (3373)..(3452)
<223>  3- U5-Region

<400>  5
ctgcctcgcg cgtttcggtg atgacggtga aaacctctga cacatgcagc tcccggagac       60

ggtcacagct tgtctgtaag cggatgccgg gagcagacaa gcccgtcagg gcgcgtcagc      120

gggtgttggc gggtgtcggg gcgcagccat gacccagtca cgtagcgata gttactatgc      180

ggcatcagag cagattgtac tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg      240

cgtaaggaga aaataccgca tcaggcgcca ttcgccattc aggctgcgca actgttggga      300

agggcgatcg gtgcgggcct cttcgctatt acgccagctg gcgaaagggg gatgtgctgc      360

aaggcgatta agttgggtaa cgccagggtt ttcccagtca cgacgttgta aaacgacggc      420

cagtgaatta gtactctagc ttaagacgcg tggcctgaaa taacctctga aagaggaact      480

tggttaggta ccttctgagg cggaaagaac cagctgtgga atgtgtgtca gttagggtgt      540

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca      600

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat      660

ctcaattagt cagcaaccat agtcccttaa gaatgtagtc ttatgcaata ctcttgtagt      720

cttgcaacat ggtaacgatg agttagcaac atgccttaca aggagagaaa aagcaccgtg      780

catgccgatt ggtggaagta aggtggtacg atcgtgcctt attaggaagg caacagacgg      840

gtctgacatg gattggacga accactgaat tgccgcattg cagagatatt gtatttaagt      900

gcctagctcg atacaataaa cgccatttga ccattcacca cattggtgtg cacctgggtt      960

gatggccgga ccgttgattc cctgacgact acgagcacct gcatgaagca gaaggcttca     1020

tttggtgacc ccgacgtgat agttagggaa tagtggtcgg ccacagacgg cgtggcgatc     1080

ctgtctccat ccgtctcgtc tatcgggagg cgagttcgat gaccctggtg gagggggctg     1140

cggcttaggg aggcagaagc tgagtaccgt cggagggagc tccagggccc ggagcgactg     1200

acccctgccg agaactcaga gggtcgtcgg aagacggaga gtgagcccga cgaccacccc     1260

aggcacgtct ttggtcggcc tgcggatcaa gcagcggccg ctagctgcag taacgccatt     1320

ttgcaaggca tggaaaaata ccaaaccaag aatagagaag ttcagatcaa gggcgggtac     1380

atgaaaatag ctaacgttgg gccaaacagg atatctgcgg tgagcagttt cggccccggc     1440

ccggggccaa gaacagatgg tcaccgcagt ttcggccccg gcccgaggcc aagaacagat     1500

ggtccccaga tatggcccaa ccctcagcag tttcttaaga cccatcagat gtttccaggc     1560

tcccccaagg acctgaaatg accctgcgcc ttatttgaat taaccaatca gcctgcttct     1620

cgcttctgtt cgcgcgcttc tgcttcccga gctctataaa agagctcaca acccctcact     1680

cggcgcgcca gtcctccgac agactgagtc ggccggtcga atcaagctta tcgataccgt     1740

cgacggatcc accggtcgcc acc atg gtg agc aag ggc gag gag ctg ttc acc     1793
                          Met Val Ser Lys Gly Glu Glu Leu Phe Thr         
                          1               5                   10          

ggg gtg gtg ccc atc ctg gtc gag ctg gac ggc gac gta aac ggc cac       1841
Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His           
                15                  20                  25                

aag ttc agc gtg tcc ggc gag ggc gag ggc gat gcc acc tac ggc aag       1889
Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys           
            30                  35                  40                    

ctg acc ctg aag ttc atc tgc acc acc ggc aag ctg ccc gtg ccc tgg       1937
Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp           
        45                  50                  55                        

ccc acc ctc gtg acc acc ctg acc tac ggc gtg cag tgc ttc agc cgc       1985
Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg           
    60                  65                  70                            

tac ccc gac cac atg aag cag cac gac ttc ttc aag tcc gcc atg ccc       2033
Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro           
75                  80                  85                  90            

gaa ggc tac gtc cag gag cgc acc atc ttc ttc aag gac gac ggc aac       2081
Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn           
                95                  100                 105               

tac aag acc cgc gcc gag gtg aag ttc gag ggc gac acc ctg gtg aac       2129
Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn           
            110                 115                 120                   

cgc atc gag ctg aag ggc atc gac ttc aag gag gac ggc aac atc ctg       2177
Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu           
        125                 130                 135                       

ggg cac aag ctg gag tac aac tac aac agc cac aac gtc tat atc atg       2225
Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met           
    140                 145                 150                           

gcc gac aag cag aag aac ggc atc aag gtg aac ttc aag atc cgc cac       2273
Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His           
155                 160                 165                 170           

aac atc gag gac ggc agc gtg cag ctc gcc gac cac tac cag cag aac       2321
Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn           
                175                 180                 185               

acc ccc atc ggc gac ggc ccc gtg ctg ctg ccc gac aac cac tac ctg       2369
Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu           
            190                 195                 200                   

agc acc cag tcc gcc ctg agc aaa gac ccc aac gag aag cgc gat cac       2417
Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His           
        205                 210                 215                       

atg gtc ctg ctg gag ttc gtg acc gcc gcc ggg atc act ctc ggc atg       2465
Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met           
    220                 225                 230                           

gac gag ctg tac aag taa agcggccgcg tcgacggatc ccccgggctg              2513
Asp Glu Leu Tyr Lys                                                       
235                                                                       

caggaattcg agcatcttac cgccatttat acccatattt gttctgtttt tcttgatttg     2573

ggtatacatt taaatgttaa taaaacaaaa tggtggggca atcatttaca tttttaggga     2633

tatgtaatta ctagttcagg tgtattgcca caagacaaac atgttaagaa actttcccgt     2693

tatttacgct ctgttcctgt taatcaacct ctggattaca aaatttgtga aagattgact     2753

gatattctta actatgttgc tccttttacg ctgtgtggat atgctgcttt aatgcctctg     2813

tatcatgcta ttgcttcccg tacggctttc gttttctcct ccttgtataa atcctggttg     2873

ctgtctcttt atgaggagtt gtggcccgtt gtccgtcaac gtggcgtggt gtgctctgtg     2933

tttgctgacg caacccccac tggctggggc attgccacca cctgtcaact cctttctggg     2993

actttcgctt tccccctccc gatcgccacg gcagaactca tcgccgcctg ccttgcccgc     3053

tgctggacag gggctaggtt gctgggcact gataattccg tggtgttgtc ggggaagctg     3113

acgtcctttc gaattcgaaa gcttttaaat atcgatgcga tgtacgggcc agatatacgc     3173

gtatctgagg ggactagggt gtgtttaggc gaaaagcggg gcttcggttg tacgcggtta     3233

ggagtcccct taggatatag tagtttcgct tttgcatagg gagggggaaa tgtagtctta     3293

tgcaatactc ttgtacgtag agatattgta tttaagtgcc tagctcgata caataaacgc     3353

catttgacca ttcaccacat tggtgtgcac ctgggttgat ggccggaccg ttgattccct     3413

gacgactacg agcacctgca tgaagcagaa ggcttcattc tcgagagctt tggcgtaatc     3473

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     3533

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     3593

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     3653

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     3713

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     3773

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     3833

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     3893

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     3953

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     4013

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     4073

atgctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     4133

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     4193

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     4253

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     4313

tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     4373

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     4433

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     4493

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     4553

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     4613

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     4673

gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat     4733

acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc     4793

ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc     4853

tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag     4913

ttcgccagtt aatagtttgc gcaacgttgt tgccattgct gctggcatcg tggtgtcacg     4973

ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg     5033

atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag     5093

taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt     5153

catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga     5213

atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc     5273

acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc     5333

aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc     5393

ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc     5453

cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca     5513

atattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat     5573

ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt     5633

ctaagaaacc attattatca tgacattaac ctataaaaat aggcgtatca cgaggccctt     5693

tcgtcttcaa g                                                          5704


<210>  6
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  7
<211>  5688
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Seq.-ID Nr. 7: viraler Vektor mit deletierter U3-Region"


<220>
<221>  enhancer
<222>  (452)..(684)
<223>  SV40 Enhancer

<220>
<221>  promoter
<222>  (693)..(921)
<223>  RSV Promotor

<220>
<221>  misc_feature
<222>  (922)..(942)
<223>  5- R-Region

<220>
<221>  misc_feature
<222>  (943)..(1022)
<223>  5- U5-Region

<220>
<221>  PBS
<222>  (1023)..(1041)
<223>  Primer Bindestelle

<220>
<221>  promoter
<222>  (1293)..(1684)
<223>  Interner Promoter der Expressionskassette: SFFV

<220>
<221>  CDS
<222>  (1764)..(2483)
<223>  EGFP: kodierende Sequenz fr eGFP

<220>
<221>  misc_feature
<222>  (2522)..(3124)
<223>  PRE der Expressionskassette

<220>
<221>  misc_feature
<222>  (3282)..(3335)
<223>  3- U3-Region mit Deletion

<220>
<221>  misc_feature
<222>  (3336)..(3356)
<223>  3-R-Region

<220>
<221>  misc_feature
<222>  (3357)..(3436)
<223>  3- U5-Region

<400>  7
ctgcctcgcg cgtttcggtg atgacggtga aaacctctga cacatgcagc tcccggagac       60

ggtcacagct tgtctgtaag cggatgccgg gagcagacaa gcccgtcagg gcgcgtcagc      120

gggtgttggc gggtgtcggg gcgcagccat gacccagtca cgtagcgata gttactatgc      180

ggcatcagag cagattgtac tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg      240

cgtaaggaga aaataccgca tcaggcgcca ttcgccattc aggctgcgca actgttggga      300

agggcgatcg gtgcgggcct cttcgctatt acgccagctg gcgaaagggg gatgtgctgc      360

aaggcgatta agttgggtaa cgccagggtt ttcccagtca cgacgttgta aaacgacggc      420

cagtgaatta gtactctagc ttaagacgcg tggcctgaaa taacctctga aagaggaact      480

tggttaggta ccttctgagg cggaaagaac cagctgtgga atgtgtgtca gttagggtgt      540

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca      600

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat      660

ctcaattagt cagcaaccat agtcccttaa gaatgtagtc ttatgcaata ctcttgtagt      720

cttgcaacat ggtaacgatg agttagcaac atgccttaca aggagagaaa aagcaccgtg      780

catgccgatt ggtggaagta aggtggtacg atcgtgcctt attaggaagg caacagacgg      840

gtctgacatg gattggacga accactgaat tgccgcattg cagagatatt gtatttaagt      900

gcctagctcg atacaataaa cgccatttga ccattcacca cattggtgtg cacctgggtt      960

gatggccgga ccgttgattc cctgacgact acgagcacct gcatgaagca gaaggcttca     1020

tttggtgacc ccgacgtgat agttagggaa tagtggtcgg ccacagacgg cgtggcgatc     1080

ctgtctccat ccgtctcgtc tatcgggagg cgagttcgat gaccctggtg gagggggctg     1140

cggcttaggg aggcagaagc tgagtaccgt cggagggagc tccagggccc ggagcgactg     1200

acccctgccg agaactcaga gggtcgtcgg aagacggaga gtgagcccga cgaccacccc     1260

aggcacgtct ttggtcggcc tgcggatcaa gcagcggccg ctagctgcag taacgccatt     1320

ttgcaaggca tggaaaaata ccaaaccaag aatagagaag ttcagatcaa gggcgggtac     1380

atgaaaatag ctaacgttgg gccaaacagg atatctgcgg tgagcagttt cggccccggc     1440

ccggggccaa gaacagatgg tcaccgcagt ttcggccccg gcccgaggcc aagaacagat     1500

ggtccccaga tatggcccaa ccctcagcag tttcttaaga cccatcagat gtttccaggc     1560

tcccccaagg acctgaaatg accctgcgcc ttatttgaat taaccaatca gcctgcttct     1620

cgcttctgtt cgcgcgcttc tgcttcccga gctctataaa agagctcaca acccctcact     1680

cggcgcgcca gtcctccgac agactgagtc ggccggtcga atcaagctta tcgataccgt     1740

cgacggatcc accggtcgcc acc atg gtg agc aag ggc gag gag ctg ttc acc     1793
                          Met Val Ser Lys Gly Glu Glu Leu Phe Thr         
                          1               5                   10          

ggg gtg gtg ccc atc ctg gtc gag ctg gac ggc gac gta aac ggc cac       1841
Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His           
                15                  20                  25                

aag ttc agc gtg tcc ggc gag ggc gag ggc gat gcc acc tac ggc aag       1889
Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys           
            30                  35                  40                    

ctg acc ctg aag ttc atc tgc acc acc ggc aag ctg ccc gtg ccc tgg       1937
Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp           
        45                  50                  55                        

ccc acc ctc gtg acc acc ctg acc tac ggc gtg cag tgc ttc agc cgc       1985
Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg           
    60                  65                  70                            

tac ccc gac cac atg aag cag cac gac ttc ttc aag tcc gcc atg ccc       2033
Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro           
75                  80                  85                  90            

gaa ggc tac gtc cag gag cgc acc atc ttc ttc aag gac gac ggc aac       2081
Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn           
                95                  100                 105               

tac aag acc cgc gcc gag gtg aag ttc gag ggc gac acc ctg gtg aac       2129
Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn           
            110                 115                 120                   

cgc atc gag ctg aag ggc atc gac ttc aag gag gac ggc aac atc ctg       2177
Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu           
        125                 130                 135                       

ggg cac aag ctg gag tac aac tac aac agc cac aac gtc tat atc atg       2225
Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met           
    140                 145                 150                           

gcc gac aag cag aag aac ggc atc aag gtg aac ttc aag atc cgc cac       2273
Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His           
155                 160                 165                 170           

aac atc gag gac ggc agc gtg cag ctc gcc gac cac tac cag cag aac       2321
Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn           
                175                 180                 185               

acc ccc atc ggc gac ggc ccc gtg ctg ctg ccc gac aac cac tac ctg       2369
Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu           
            190                 195                 200                   

agc acc cag tcc gcc ctg agc aaa gac ccc aac gag aag cgc gat cac       2417
Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His           
        205                 210                 215                       

atg gtc ctg ctg gag ttc gtg acc gcc gcc ggg atc act ctc ggc atg       2465
Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met           
    220                 225                 230                           

gac gag ctg tac aag taa agcggccgcg tcgacggatc ccccgggctg              2513
Asp Glu Leu Tyr Lys                                                       
235                                                                       

caggaattcg agcatcttac cgccatttat acccatattt gttctgtttt tcttgatttg     2573

ggtatacatt taaatgttaa taaaacaaaa tggtggggca atcatttaca tttttaggga     2633

tatgtaatta ctagttcagg tgtattgcca caagacaaac atgttaagaa actttcccgt     2693

tatttacgct ctgttcctgt taatcaacct ctggattaca aaatttgtga aagattgact     2753

gatattctta actatgttgc tccttttacg ctgtgtggat atgctgcttt aatgcctctg     2813

tatcatgcta ttgcttcccg tacggctttc gttttctcct ccttgtataa atcctggttg     2873

ctgtctcttt atgaggagtt gtggcccgtt gtccgtcaac gtggcgtggt gtgctctgtg     2933

tttgctgacg caacccccac tggctggggc attgccacca cctgtcaact cctttctggg     2993

actttcgctt tccccctccc gatcgccacg gcagaactca tcgccgcctg ccttgcccgc     3053

tgctggacag gggctaggtt gctgggcact gataattccg tggtgttgtc ggggaagctg     3113

acgtcctttc gaattcgaaa gcttttaaat atcgatgcga tgtacgggcc agatatacgc     3173

gtatctgagg ggactagggt gtgtttaggc gaaaagcggg gcttcggttg tacgcggtta     3233

ggagtcccct taggatatag tagtttcgct tttgcatagg gagggggaaa tgtagtctta     3293

tgcaatactc ttgtacgtag tgcctagctc gatacaataa acgccatttg accattcacc     3353

acattggtgt gcacctgggt tgatggccgg accgttgatt ccctgacgac tacgagcacc     3413

tgcatgaagc agaaggcttc attctcgaga gctttggcgt aatcatggtc atagctgttt     3473

cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg aagcataaag     3533

tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt gcgctcactg     3593

cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg     3653

gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga ctcgctgcgc     3713

tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc     3773

acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg     3833

aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat     3893

cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag     3953

gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga     4013

tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc acgctgtagg     4073

tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt     4133

cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac     4193

gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc     4253

ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt     4313

ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc     4373

ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc     4433

agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg     4493

aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag     4553

atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg     4613

tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt     4673

tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca     4733

tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca     4793

gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc     4853

tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt     4913

ttgcgcaacg ttgttgccat tgctgctggc atcgtggtgt cacgctcgtc gtttggtatg     4973

gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc     5033

aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg     5093

ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga     5153

tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga     5213

ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta     5273

aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg     5333

ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact     5393

ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata     5453

agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt     5513

tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa     5573

ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt     5633

atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct tcaag          5688


<210>  8
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  9
<211>  5704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Seq.-ID Nr. 9: viraler Vektor mit Deletion und mutierter 
       TATA-Box in 3-U3-Region"


<220>
<221>  enhancer
<222>  (452)..(684)
<223>  SV40 enhancer

<220>
<221>  promoter
<222>  (693)..(921)
<223>  RSV Promotor

<220>
<221>  misc_feature
<222>  (922)..(942)
<223>  5- R-Region

<220>
<221>  misc_feature
<222>  (943)..(1022)
<223>  5- U5-Region

<220>
<221>  PBS
<222>  (1023)..(1041)

<220>
<221>  promoter
<222>  (1293)..(1684)
<223>  SFFV Promotor

<220>
<221>  CDS
<222>  (1764)..(2483)
<223>  EGFP: kodierende Sequenz fr eGFP

<220>
<221>  misc_signal
<222>  (2522)..(3124)
<223>  PRE

<220>
<221>  misc_feature
<222>  (3282)..(3351)
<223>  deletierte 3- U3

<220>
<221>  misc_feature
<222>  (3322)..(3328)
<223>  mutierte TATA Box in deletierter 3- U3

<220>
<221>  misc_feature
<222>  (3352)..(3372)
<223>  3- R-Region

<220>
<221>  misc_feature
<222>  (3373)..(3452)
<223>  3-U5-Region

<400>  9
ctgcctcgcg cgtttcggtg atgacggtga aaacctctga cacatgcagc tcccggagac       60

ggtcacagct tgtctgtaag cggatgccgg gagcagacaa gcccgtcagg gcgcgtcagc      120

gggtgttggc gggtgtcggg gcgcagccat gacccagtca cgtagcgata gttactatgc      180

ggcatcagag cagattgtac tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg      240

cgtaaggaga aaataccgca tcaggcgcca ttcgccattc aggctgcgca actgttggga      300

agggcgatcg gtgcgggcct cttcgctatt acgccagctg gcgaaagggg gatgtgctgc      360

aaggcgatta agttgggtaa cgccagggtt ttcccagtca cgacgttgta aaacgacggc      420

cagtgaatta gtactctagc ttaagacgcg tggcctgaaa taacctctga aagaggaact      480

tggttaggta ccttctgagg cggaaagaac cagctgtgga atgtgtgtca gttagggtgt      540

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca      600

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat      660

ctcaattagt cagcaaccat agtcccttaa gaatgtagtc ttatgcaata ctcttgtagt      720

cttgcaacat ggtaacgatg agttagcaac atgccttaca aggagagaaa aagcaccgtg      780

catgccgatt ggtggaagta aggtggtacg atcgtgcctt attaggaagg caacagacgg      840

gtctgacatg gattggacga accactgaat tgccgcattg cagagatatt gtatttaagt      900

gcctagctcg atacaataaa cgccatttga ccattcacca cattggtgtg cacctgggtt      960

gatggccgga ccgttgattc cctgacgact acgagcacct gcatgaagca gaaggcttca     1020

tttggtgacc ccgacgtgat agttagggaa tagtggtcgg ccacagacgg cgtggcgatc     1080

ctgtctccat ccgtctcgtc tatcgggagg cgagttcgat gaccctggtg gagggggctg     1140

cggcttaggg aggcagaagc tgagtaccgt cggagggagc tccagggccc ggagcgactg     1200

acccctgccg agaactcaga gggtcgtcgg aagacggaga gtgagcccga cgaccacccc     1260

aggcacgtct ttggtcggcc tgcggatcaa gcagcggccg ctagctgcag taacgccatt     1320

ttgcaaggca tggaaaaata ccaaaccaag aatagagaag ttcagatcaa gggcgggtac     1380

atgaaaatag ctaacgttgg gccaaacagg atatctgcgg tgagcagttt cggccccggc     1440

ccggggccaa gaacagatgg tcaccgcagt ttcggccccg gcccgaggcc aagaacagat     1500

ggtccccaga tatggcccaa ccctcagcag tttcttaaga cccatcagat gtttccaggc     1560

tcccccaagg acctgaaatg accctgcgcc ttatttgaat taaccaatca gcctgcttct     1620

cgcttctgtt cgcgcgcttc tgcttcccga gctctataaa agagctcaca acccctcact     1680

cggcgcgcca gtcctccgac agactgagtc ggccggtcga atcaagctta tcgataccgt     1740

cgacggatcc accggtcgcc acc atg gtg agc aag ggc gag gag ctg ttc acc     1793
                          Met Val Ser Lys Gly Glu Glu Leu Phe Thr         
                          1               5                   10          

ggg gtg gtg ccc atc ctg gtc gag ctg gac ggc gac gta aac ggc cac       1841
Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His           
                15                  20                  25                

aag ttc agc gtg tcc ggc gag ggc gag ggc gat gcc acc tac ggc aag       1889
Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys           
            30                  35                  40                    

ctg acc ctg aag ttc atc tgc acc acc ggc aag ctg ccc gtg ccc tgg       1937
Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp           
        45                  50                  55                        

ccc acc ctc gtg acc acc ctg acc tac ggc gtg cag tgc ttc agc cgc       1985
Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg           
    60                  65                  70                            

tac ccc gac cac atg aag cag cac gac ttc ttc aag tcc gcc atg ccc       2033
Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro           
75                  80                  85                  90            

gaa ggc tac gtc cag gag cgc acc atc ttc ttc aag gac gac ggc aac       2081
Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn           
                95                  100                 105               

tac aag acc cgc gcc gag gtg aag ttc gag ggc gac acc ctg gtg aac       2129
Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn           
            110                 115                 120                   

cgc atc gag ctg aag ggc atc gac ttc aag gag gac ggc aac atc ctg       2177
Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu           
        125                 130                 135                       

ggg cac aag ctg gag tac aac tac aac agc cac aac gtc tat atc atg       2225
Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met           
    140                 145                 150                           

gcc gac aag cag aag aac ggc atc aag gtg aac ttc aag atc cgc cac       2273
Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His           
155                 160                 165                 170           

aac atc gag gac ggc agc gtg cag ctc gcc gac cac tac cag cag aac       2321
Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn           
                175                 180                 185               

acc ccc atc ggc gac ggc ccc gtg ctg ctg ccc gac aac cac tac ctg       2369
Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu           
            190                 195                 200                   

agc acc cag tcc gcc ctg agc aaa gac ccc aac gag aag cgc gat cac       2417
Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His           
        205                 210                 215                       

atg gtc ctg ctg gag ttc gtg acc gcc gcc ggg atc act ctc ggc atg       2465
Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met           
    220                 225                 230                           

gac gag ctg tac aag taa agcggccgcg tcgacggatc ccccgggctg              2513
Asp Glu Leu Tyr Lys                                                       
235                                                                       

caggaattcg agcatcttac cgccatttat acccatattt gttctgtttt tcttgatttg     2573

ggtatacatt taaatgttaa taaaacaaaa tggtggggca atcatttaca tttttaggga     2633

tatgtaatta ctagttcagg tgtattgcca caagacaaac atgttaagaa actttcccgt     2693

tatttacgct ctgttcctgt taatcaacct ctggattaca aaatttgtga aagattgact     2753

gatattctta actatgttgc tccttttacg ctgtgtggat atgctgcttt aatgcctctg     2813

tatcatgcta ttgcttcccg tacggctttc gttttctcct ccttgtataa atcctggttg     2873

ctgtctcttt atgaggagtt gtggcccgtt gtccgtcaac gtggcgtggt gtgctctgtg     2933

tttgctgacg caacccccac tggctggggc attgccacca cctgtcaact cctttctggg     2993

actttcgctt tccccctccc gatcgccacg gcagaactca tcgccgcctg ccttgcccgc     3053

tgctggacag gggctaggtt gctgggcact gataattccg tggtgttgtc ggggaagctg     3113

acgtcctttc gaattcgaaa gcttttaaat atcgatgcga tgtacgggcc agatatacgc     3173

gtatctgagg ggactagggt gtgtttaggc gaaaagcggg gcttcggttg tacgcggtta     3233

ggagtcccct taggatatag tagtttcgct tttgcatagg gagggggaaa tgtagtctta     3293

tgcaatactc ttgtacgtag agatattgtg tctaagtgcc tagctcgata caataaacgc     3353

catttgacca ttcaccacat tggtgtgcac ctgggttgat ggccggaccg ttgattccct     3413

gacgactacg agcacctgca tgaagcagaa ggcttcattc tcgagagctt tggcgtaatc     3473

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     3533

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     3593

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     3653

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     3713

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     3773

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     3833

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     3893

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     3953

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     4013

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     4073

atgctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     4133

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     4193

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     4253

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     4313

tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     4373

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     4433

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     4493

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     4553

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     4613

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     4673

gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat     4733

acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc     4793

ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc     4853

tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag     4913

ttcgccagtt aatagtttgc gcaacgttgt tgccattgct gctggcatcg tggtgtcacg     4973

ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg     5033

atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag     5093

taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt     5153

catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga     5213

atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc     5273

acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc     5333

aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc     5393

ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc     5453

cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca     5513

atattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat     5573

ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt     5633

ctaagaaacc attattatca tgacattaac ctataaaaat aggcgtatca cgaggccctt     5693

tcgtcttcaa g                                                          5704


<210>  10
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  11
<211>  10768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Seq.-ID Nr. 11: 1. Helferplasmid gag-pol (Wildtyp)"


<220>
<221>  promoter
<222>  (232)..(819)
<223>  CMV Promotor

<220>
<221>  Intron
<222>  (907)..(1463)
<223>  beta Globin-Intron

<220>
<221>  CDS
<222>  (1475)..(3586)
<223>  gag: kodierende Sequenz fr Gag, Wildtyp

<220>
<221>  CDS
<222>  (3604)..(6291)
<223>  pol: kodierende Sequenz fr Pol, Wildtyp

<220>
<221>  polyA_signal
<222>  (6368)..(6588)
<223>  poly-Adenylierungselement von bGH

<400>  11
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cctgagaact tcagggtgag tctatgggac ccttgatgtt ttctttcccc      960

ttcttttcta tggttaagtt catgtcatag gaaggggaga agtaacaggg tacacatatt     1020

gaccaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata     1080

cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag ggcaataatg     1140

atacaatgta tcatgcctct ttgcaccatt ctaaagaata acagtgataa tttctgggtt     1200

aaggcaatag caatatttct gcatataaat atttctgcat ataaattgta actgatgtaa     1260

gaggtttcat attgctaata gcagctacaa tccagctacc attctgcttt tattttatgg     1320

ttgggataag gctggattat tctgagtcca agctaggccc ttttgctaat catgttcata     1380

cctcttatct tcctcccaca gctcctgggc aacgtgctgg tctgtgtgct ggcccatcac     1440

tttggcaaag cacgtgagat ctgaattcgc cacc atg gaa gcc gtc att aag gtg     1495
                                      Met Glu Ala Val Ile Lys Val         
                                      1               5                   

att tcg tcc gcg tgt aaa acc tat tgc ggg aaa atc tct cct tct aag       1543
Ile Ser Ser Ala Cys Lys Thr Tyr Cys Gly Lys Ile Ser Pro Ser Lys           
        10                  15                  20                        

aag gaa ata ggg gcc atg ttg tcc ctg tta caa aag gaa ggg ttg ctt       1591
Lys Glu Ile Gly Ala Met Leu Ser Leu Leu Gln Lys Glu Gly Leu Leu           
    25                  30                  35                            

atg tct ccc tca gat tta tat tct ccg ggg tcc tgg gat ccc atc act       1639
Met Ser Pro Ser Asp Leu Tyr Ser Pro Gly Ser Trp Asp Pro Ile Thr           
40                  45                  50                  55            

gcg gcg ctc tcc cag cgg gca atg gta ctt gga aaa tcg gga gag tta       1687
Ala Ala Leu Ser Gln Arg Ala Met Val Leu Gly Lys Ser Gly Glu Leu           
                60                  65                  70                

aaa acc tgg gga ttg gtt ttg ggg gca ttg aag gcg gct cga gag gaa       1735
Lys Thr Trp Gly Leu Val Leu Gly Ala Leu Lys Ala Ala Arg Glu Glu           
            75                  80                  85                    

cag gtt aca tct gag caa gca aag ttt tgg ttg gga tta ggg gga ggg       1783
Gln Val Thr Ser Glu Gln Ala Lys Phe Trp Leu Gly Leu Gly Gly Gly           
        90                  95                  100                       

agg gtc tct ccc cca ggt ccg gag tgc atc gag aaa cca gct acg gag       1831
Arg Val Ser Pro Pro Gly Pro Glu Cys Ile Glu Lys Pro Ala Thr Glu           
    105                 110                 115                           

cgg cga atc gac aaa ggg gag gag gtg gga gaa aca act gtg cag cga       1879
Arg Arg Ile Asp Lys Gly Glu Glu Val Gly Glu Thr Thr Val Gln Arg           
120                 125                 130                 135           

gat gcg aag atg gcg cca gag gaa gcg gcc aca cct aaa acc gtt ggc       1927
Asp Ala Lys Met Ala Pro Glu Glu Ala Ala Thr Pro Lys Thr Val Gly           
                140                 145                 150               

aca tcc tgc tat cat tgc gga aca gct gtt ggc tgc aat tgc gcc acc       1975
Thr Ser Cys Tyr His Cys Gly Thr Ala Val Gly Cys Asn Cys Ala Thr           
            155                 160                 165                   

gcc aca gcc tcg gcc cct cct ccc cct tat gtg ggg agt ggt ttg tat       2023
Ala Thr Ala Ser Ala Pro Pro Pro Pro Tyr Val Gly Ser Gly Leu Tyr           
        170                 175                 180                       

cct tcc ctg gcg ggg gtg gga gag cag cag ggc cag gga gat aac acg       2071
Pro Ser Leu Ala Gly Val Gly Glu Gln Gln Gly Gln Gly Asp Asn Thr           
    185                 190                 195                           

tct cgg ggg gcg gag cag cca agg gag gag cca ggg cac gcg ggt cag       2119
Ser Arg Gly Ala Glu Gln Pro Arg Glu Glu Pro Gly His Ala Gly Gln           
200                 205                 210                 215           

gcc cct ggg ccg gcc ctg act gac tgg gca agg gta agg gag gag ctt       2167
Ala Pro Gly Pro Ala Leu Thr Asp Trp Ala Arg Val Arg Glu Glu Leu           
                220                 225                 230               

gcg agt act ggt ccg ccc gtg gtg gcc atg cct gta gtg att aag aca       2215
Ala Ser Thr Gly Pro Pro Val Val Ala Met Pro Val Val Ile Lys Thr           
            235                 240                 245                   

gag gga ccc gcc tgg acc cct ctg gag cca aaa ttg atc aca aga ctg       2263
Glu Gly Pro Ala Trp Thr Pro Leu Glu Pro Lys Leu Ile Thr Arg Leu           
        250                 255                 260                       

gct gat acg gtc agg acc aag ggc tta cga tcc ccg atc act atg gca       2311
Ala Asp Thr Val Arg Thr Lys Gly Leu Arg Ser Pro Ile Thr Met Ala           
    265                 270                 275                           

gaa gtg gaa gcg ctc atg tcc tcc ccg ttg ctg ccg cat gac gtc acg       2359
Glu Val Glu Ala Leu Met Ser Ser Pro Leu Leu Pro His Asp Val Thr           
280                 285                 290                 295           

aat cta atg aga gtg att tta gga cct gcc cca tat gcc tta tgg atg       2407
Asn Leu Met Arg Val Ile Leu Gly Pro Ala Pro Tyr Ala Leu Trp Met           
                300                 305                 310               

gac gct tgg gga gtc caa ctc cag acg gtt ata gcg gca gcc act cgc       2455
Asp Ala Trp Gly Val Gln Leu Gln Thr Val Ile Ala Ala Ala Thr Arg           
            315                 320                 325                   

gac ccc cga cac cca gcg aac ggt caa ggg cgg ggg gaa cgg act aac       2503
Asp Pro Arg His Pro Ala Asn Gly Gln Gly Arg Gly Glu Arg Thr Asn           
        330                 335                 340                       

ttg gat cga tta aag ggc tta gct gat ggg atg gtg ggc aac cca cag       2551
Leu Asp Arg Leu Lys Gly Leu Ala Asp Gly Met Val Gly Asn Pro Gln           
    345                 350                 355                           

ggt cag gcc gca tta tta aga ccg ggg gaa ttg gtt gct att acg gcg       2599
Gly Gln Ala Ala Leu Leu Arg Pro Gly Glu Leu Val Ala Ile Thr Ala           
360                 365                 370                 375           

tcg gct ctc cag gcg ttt aga gaa gtt gcc cgg ctg gcg gaa cct gca       2647
Ser Ala Leu Gln Ala Phe Arg Glu Val Ala Arg Leu Ala Glu Pro Ala           
                380                 385                 390               

ggt cca tgg gcg gac atc acg cag gga cca tct gag tcc ttt gtt gat       2695
Gly Pro Trp Ala Asp Ile Thr Gln Gly Pro Ser Glu Ser Phe Val Asp           
            395                 400                 405                   

ttt gcc aat cgg ctt ata aag gcg gtt gag ggg tca gat ctc ccg cct       2743
Phe Ala Asn Arg Leu Ile Lys Ala Val Glu Gly Ser Asp Leu Pro Pro           
        410                 415                 420                       

tcc gcg cgg gct ccg gtg atc att gac tgc ttt agg cag aag tca cag       2791
Ser Ala Arg Ala Pro Val Ile Ile Asp Cys Phe Arg Gln Lys Ser Gln           
    425                 430                 435                           

cca gat att cag cag ctt ata cgg gca gca ccc tcc acg ctg acc acc       2839
Pro Asp Ile Gln Gln Leu Ile Arg Ala Ala Pro Ser Thr Leu Thr Thr           
440                 445                 450                 455           

cca gga gag ata atc aaa tat gtg cta gac agg cag aag att gcc cct       2887
Pro Gly Glu Ile Ile Lys Tyr Val Leu Asp Arg Gln Lys Ile Ala Pro           
                460                 465                 470               

ctt acg gat caa ggc ata gcc gcg gcc atg tcg tct gct atc cag ccc       2935
Leu Thr Asp Gln Gly Ile Ala Ala Ala Met Ser Ser Ala Ile Gln Pro           
            475                 480                 485                   

tta gtt atg gca gta gtc aat aga gag agg gat gga caa act ggg tcg       2983
Leu Val Met Ala Val Val Asn Arg Glu Arg Asp Gly Gln Thr Gly Ser           
        490                 495                 500                       

ggt ggt cgt gcc cga ggg ctc tgc tac act tgt gga tcc ccg gga cat       3031
Gly Gly Arg Ala Arg Gly Leu Cys Tyr Thr Cys Gly Ser Pro Gly His           
    505                 510                 515                           

tat cag gca cag tgc ccg aaa aaa cga aag tca gga aac agc cgt gag       3079
Tyr Gln Ala Gln Cys Pro Lys Lys Arg Lys Ser Gly Asn Ser Arg Glu           
520                 525                 530                 535           

cga tgt cag ctg tgt gac ggg atg gga cac aac gct aaa cag tgt agg       3127
Arg Cys Gln Leu Cys Asp Gly Met Gly His Asn Ala Lys Gln Cys Arg           
                540                 545                 550               

aag cgg gat ggc aac cag ggc caa cgc cca gga aga ggt ctc tct tcg       3175
Lys Arg Asp Gly Asn Gln Gly Gln Arg Pro Gly Arg Gly Leu Ser Ser           
            555                 560                 565                   

ggg ccg tgg ccc ggc cct gag cag cct gcc gtc tcg tta gcg atg aca       3223
Gly Pro Trp Pro Gly Pro Glu Gln Pro Ala Val Ser Leu Ala Met Thr           
        570                 575                 580                       

atg gaa cat aaa gat cgc ccc ttg gtt agg gtc att ctg act aac act       3271
Met Glu His Lys Asp Arg Pro Leu Val Arg Val Ile Leu Thr Asn Thr           
    585                 590                 595                           

ggg agt cat cca gtc aaa caa cgt tcg gtg tat atc acc gcg ctg ttg       3319
Gly Ser His Pro Val Lys Gln Arg Ser Val Tyr Ile Thr Ala Leu Leu           
600                 605                 610                 615           

gac tcc gga gcg gac atc act att att tcg gag gag gat tgg cct act       3367
Asp Ser Gly Ala Asp Ile Thr Ile Ile Ser Glu Glu Asp Trp Pro Thr           
                620                 625                 630               

gat tgg ccg gtg gtg gac acc gcg aac cca cag atc cat ggc ata gga       3415
Asp Trp Pro Val Val Asp Thr Ala Asn Pro Gln Ile His Gly Ile Gly           
            635                 640                 645                   

ggg gga att ccc atg cga aaa tcc cgg gat atg ata gag gtg ggg gtt       3463
Gly Gly Ile Pro Met Arg Lys Ser Arg Asp Met Ile Glu Val Gly Val           
        650                 655                 660                       

att aac cga gac ggg tcg ttg gag cga ccc ctg ctc ctc ttc ccc gca       3511
Ile Asn Arg Asp Gly Ser Leu Glu Arg Pro Leu Leu Leu Phe Pro Ala           
    665                 670                 675                           

gtc gct atg gtt aga ggg agt atc cta gga aga gat tgt ctg cag ggc       3559
Val Ala Met Val Arg Gly Ser Ile Leu Gly Arg Asp Cys Leu Gln Gly           
680                 685                 690                 695           

cta ggg ctc cgc ttg aca aat tta tag ggagggccac tgttctt act gtt        3609
Leu Gly Leu Arg Leu Thr Asn Leu                        Thr Val            
                700                                        705            

gcg cta cat ctg gct att ccg ctc aaa tgg aag tca gac cgc acg cct       3657
Ala Leu His Leu Ala Ile Pro Leu Lys Trp Lys Ser Asp Arg Thr Pro           
                710                 715                 720               

gtg tgg att gac cag tgg ccc ctt cct gaa ggt aaa ctt gta gcg cta       3705
Val Trp Ile Asp Gln Trp Pro Leu Pro Glu Gly Lys Leu Val Ala Leu           
            725                 730                 735                   

acg caa tta gtg gaa aaa gaa tta cag tta gga cat ata gag ccc tca       3753
Thr Gln Leu Val Glu Lys Glu Leu Gln Leu Gly His Ile Glu Pro Ser           
        740                 745                 750                       

ctt agt tgt tgg aac aca cct gtt ttt gtg atc cgg aag gct tcc ggg       3801
Leu Ser Cys Trp Asn Thr Pro Val Phe Val Ile Arg Lys Ala Ser Gly           
    755                 760                 765                           

tct tat cgc tta ttg cat gat ttg cgc gct gtt aac gcc aag ctt gtc       3849
Ser Tyr Arg Leu Leu His Asp Leu Arg Ala Val Asn Ala Lys Leu Val           
770                 775                 780                 785           

cct ttt ggg gcc gtc caa cag ggg gcg cca gtt ctc tcc gcg ctc ccg       3897
Pro Phe Gly Ala Val Gln Gln Gly Ala Pro Val Leu Ser Ala Leu Pro           
                790                 795                 800               

cgt ggc tgg ccc ctg atg gtc cta gac ctc aag gat tgc ttc ttt tct       3945
Arg Gly Trp Pro Leu Met Val Leu Asp Leu Lys Asp Cys Phe Phe Ser           
            805                 810                 815                   

atc cct ctt gcg gaa caa gat cgc gaa gct ttt gca ttt acg ctc ccc       3993
Ile Pro Leu Ala Glu Gln Asp Arg Glu Ala Phe Ala Phe Thr Leu Pro           
        820                 825                 830                       

tct gtg aat aac cag gcc ccc gct cga aga ttc caa tgg aag gtc ttg       4041
Ser Val Asn Asn Gln Ala Pro Ala Arg Arg Phe Gln Trp Lys Val Leu           
    835                 840                 845                           

ccc caa ggg atg acc tgt tct ccc act atc tgt cag ttg gta gtg ggt       4089
Pro Gln Gly Met Thr Cys Ser Pro Thr Ile Cys Gln Leu Val Val Gly           
850                 855                 860                 865           

cag gtg ctc gag ccc ttg cga ctc aag cac cca gct ctg cgc atg ttg       4137
Gln Val Leu Glu Pro Leu Arg Leu Lys His Pro Ala Leu Arg Met Leu           
                870                 875                 880               

cat tat atg gac gat ctt ttg cta gcc gcc tca agt cat gat ggg ttg       4185
His Tyr Met Asp Asp Leu Leu Leu Ala Ala Ser Ser His Asp Gly Leu           
            885                 890                 895                   

gaa gcg gca ggg aag gag gtt atc ggt aca ttg gaa aga gcc ggg ttc       4233
Glu Ala Ala Gly Lys Glu Val Ile Gly Thr Leu Glu Arg Ala Gly Phe           
        900                 905                 910                       

act att tcg ccg gat aag atc cag agg gag ccc gga gta caa tat ctt       4281
Thr Ile Ser Pro Asp Lys Ile Gln Arg Glu Pro Gly Val Gln Tyr Leu           
    915                 920                 925                           

ggg tac aag tta ggc agt acg tat gta gca ccc gta ggc ttg gta gca       4329
Gly Tyr Lys Leu Gly Ser Thr Tyr Val Ala Pro Val Gly Leu Val Ala           
930                 935                 940                 945           

gaa ccc agg ata gcc acc ttg tgg gat gtt caa aag ctg gtg ggg tca       4377
Glu Pro Arg Ile Ala Thr Leu Trp Asp Val Gln Lys Leu Val Gly Ser           
                950                 955                 960               

ctt cag tgg ctt cgc cca gcg tta ggg atc ccg cca cga ctg atg ggt       4425
Leu Gln Trp Leu Arg Pro Ala Leu Gly Ile Pro Pro Arg Leu Met Gly           
            965                 970                 975                   

ccc ttt tat gag cag tta cga ggg tca gat cct aac gag gcg agg gaa       4473
Pro Phe Tyr Glu Gln Leu Arg Gly Ser Asp Pro Asn Glu Ala Arg Glu           
        980                 985                 990                       

tgg aat cta gac atg aaa atg  gcc tgg aga gag atc  gta cag ctt agc     4521
Trp Asn Leu Asp Met Lys Met  Ala Trp Arg Glu Ile  Val Gln Leu Ser         
    995                 1000                 1005                         

act  act gct gcc ttg gaa  cga tgg gac cct gcc  cag cct ctg gaa        4566
Thr  Thr Ala Ala Leu Glu  Arg Trp Asp Pro Ala  Gln Pro Leu Glu            
1010                 1015                 1020                            

gga  gcg gtc gct aga tgt  gaa cag ggg gca ata  ggg gtc ctg gga        4611
Gly  Ala Val Ala Arg Cys  Glu Gln Gly Ala Ile  Gly Val Leu Gly            
1025                 1030                 1035                            

cag  gga ctg tcc aca cac  cca agg cca tgt ttg  tgg tta ttc tcc        4656
Gln  Gly Leu Ser Thr His  Pro Arg Pro Cys Leu  Trp Leu Phe Ser            
1040                 1045                 1050                            

acc  caa ccc acc aag gcg  ttt act gct tgg tta  gaa gtg ctc acc        4701
Thr  Gln Pro Thr Lys Ala  Phe Thr Ala Trp Leu  Glu Val Leu Thr            
1055                 1060                 1065                            

ctt  ttg att act aag cta  cgc gct tcg gca gtg  cga acc ttt ggc        4746
Leu  Leu Ile Thr Lys Leu  Arg Ala Ser Ala Val  Arg Thr Phe Gly            
1070                 1075                 1080                            

aag  gag gtt gat atc ctc  ctg ttg cct gca tgc  ttc cgg gag gac        4791
Lys  Glu Val Asp Ile Leu  Leu Leu Pro Ala Cys  Phe Arg Glu Asp            
1085                 1090                 1095                            

ctt  ccg ctc ccg gag ggg  atc ctg tta gca ctt  agg ggg ttt gca        4836
Leu  Pro Leu Pro Glu Gly  Ile Leu Leu Ala Leu  Arg Gly Phe Ala            
1100                 1105                 1110                            

gga  aaa atc agg agt agt  gac acg cca tct att  ttt gac att gcg        4881
Gly  Lys Ile Arg Ser Ser  Asp Thr Pro Ser Ile  Phe Asp Ile Ala            
1115                 1120                 1125                            

cgt  cca ctg cat gtt tct  ctg aaa gtg agg gtt  acc gac cac cct        4926
Arg  Pro Leu His Val Ser  Leu Lys Val Arg Val  Thr Asp His Pro            
1130                 1135                 1140                            

gtg  ccg gga ccc act gtc  ttt acc gac gcc tcc  tca agc acc cat        4971
Val  Pro Gly Pro Thr Val  Phe Thr Asp Ala Ser  Ser Ser Thr His            
1145                 1150                 1155                            

aaa  ggg gtg gta gtc tgg  agg gag ggc cca agg  tgg gag ata aaa        5016
Lys  Gly Val Val Val Trp  Arg Glu Gly Pro Arg  Trp Glu Ile Lys            
1160                 1165                 1170                            

gaa  ata gtt gat ttg ggg  gca agt gta caa caa  ctg gag gca cgc        5061
Glu  Ile Val Asp Leu Gly  Ala Ser Val Gln Gln  Leu Glu Ala Arg            
1175                 1180                 1185                            

gct  gtg gcc atg gca ctt  ctg ctg tgg ccg aca  acg ccc act aat        5106
Ala  Val Ala Met Ala Leu  Leu Leu Trp Pro Thr  Thr Pro Thr Asn            
1190                 1195                 1200                            

gta  gtg act gac tct gcg  ttt gtt gcg aaa atg  tta ctc aag atg        5151
Val  Val Thr Asp Ser Ala  Phe Val Ala Lys Met  Leu Leu Lys Met            
1205                 1210                 1215                            

gga  cag gag gga gtc ccg  tct aca gcg gca gct  ttt att tta gag        5196
Gly  Gln Glu Gly Val Pro  Ser Thr Ala Ala Ala  Phe Ile Leu Glu            
1220                 1225                 1230                            

gat  gcg tta agc caa agg  tca gcc atg gcc gcc  gtt ctc cac gtg        5241
Asp  Ala Leu Ser Gln Arg  Ser Ala Met Ala Ala  Val Leu His Val            
1235                 1240                 1245                            

cgg  agt cat tct gaa gtg  cca ggg ttt ttc aca  gaa gga aat gac        5286
Arg  Ser His Ser Glu Val  Pro Gly Phe Phe Thr  Glu Gly Asn Asp            
1250                 1255                 1260                            

gtg  gca gat agc caa gcc  acc ttt caa gcg tat  ccc ttg aga gag        5331
Val  Ala Asp Ser Gln Ala  Thr Phe Gln Ala Tyr  Pro Leu Arg Glu            
1265                 1270                 1275                            

gct  aaa gat ctt cat acc  gct ctc cat att gga  ccc cgc gcg cta        5376
Ala  Lys Asp Leu His Thr  Ala Leu His Ile Gly  Pro Arg Ala Leu            
1280                 1285                 1290                            

tcc  aaa gcg tgt aat ata  tct atg cag cag gct  agg gag gtt gtt        5421
Ser  Lys Ala Cys Asn Ile  Ser Met Gln Gln Ala  Arg Glu Val Val            
1295                 1300                 1305                            

cag  acc tgc ccg cat tgt  aat tca gcc cct gcg  ttg gag gcc ggg        5466
Gln  Thr Cys Pro His Cys  Asn Ser Ala Pro Ala  Leu Glu Ala Gly            
1310                 1315                 1320                            

gta  aac cct agg ggt ttg  gga ccc cta cag ata  tgg cag aca gac        5511
Val  Asn Pro Arg Gly Leu  Gly Pro Leu Gln Ile  Trp Gln Thr Asp            
1325                 1330                 1335                            

ttt  acg ctt gag cct aga  atg gct ccc cgt tcc  tgg ctc gct gtt        5556
Phe  Thr Leu Glu Pro Arg  Met Ala Pro Arg Ser  Trp Leu Ala Val            
1340                 1345                 1350                            

act  gtg gac acc gcc tca  tca gcg ata gtc gta  act cag cat ggc        5601
Thr  Val Asp Thr Ala Ser  Ser Ala Ile Val Val  Thr Gln His Gly            
1355                 1360                 1365                            

cgt  gtt aca tcg gtt gct  gca caa cat cat tgg  gcc acg gct atc        5646
Arg  Val Thr Ser Val Ala  Ala Gln His His Trp  Ala Thr Ala Ile            
1370                 1375                 1380                            

gcc  gtt ttg gga aga cca  aag gcc ata aaa aca  gat aac ggg tcc        5691
Ala  Val Leu Gly Arg Pro  Lys Ala Ile Lys Thr  Asp Asn Gly Ser            
1385                 1390                 1395                            

tgc  ttc acg tct aga tcc  acg cgg gag tgg ctc  gcg aga tgg ggg        5736
Cys  Phe Thr Ser Arg Ser  Thr Arg Glu Trp Leu  Ala Arg Trp Gly            
1400                 1405                 1410                            

ata  gca cac acc acc ggg  att ccg gga aat tcc  cag ggt caa gct        5781
Ile  Ala His Thr Thr Gly  Ile Pro Gly Asn Ser  Gln Gly Gln Ala            
1415                 1420                 1425                            

atg  gta gag cgg gcc aac  cgg ctc ctg aaa gat  aag atc cgt gtg        5826
Met  Val Glu Arg Ala Asn  Arg Leu Leu Lys Asp  Lys Ile Arg Val            
1430                 1435                 1440                            

ctt  gcg gag ggg gac ggc  ttt atg aaa aga atc  ccc gcc agc aaa        5871
Leu  Ala Glu Gly Asp Gly  Phe Met Lys Arg Ile  Pro Ala Ser Lys            
1445                 1450                 1455                            

cag  ggg gaa cta cta gcc  aag gca atg tat gcc  ctc aat cac ttt        5916
Gln  Gly Glu Leu Leu Ala  Lys Ala Met Tyr Ala  Leu Asn His Phe            
1460                 1465                 1470                            

gag  cgt ggt gaa aac aca  aaa aca ccg gta caa  aaa cac tgg aga        5961
Glu  Arg Gly Glu Asn Thr  Lys Thr Pro Val Gln  Lys His Trp Arg            
1475                 1480                 1485                            

cct  acc gtt ctt aca gaa  gga ccc ccg gtt aaa  ata cga ata gag        6006
Pro  Thr Val Leu Thr Glu  Gly Pro Pro Val Lys  Ile Arg Ile Glu            
1490                 1495                 1500                            

aca  ggg gag tgg gaa aaa  gga tgg aac gtg ctg  gtc tgg gga cga        6051
Thr  Gly Glu Trp Glu Lys  Gly Trp Asn Val Leu  Val Trp Gly Arg            
1505                 1510                 1515                            

ggt  tat gcc gct gtg aaa  aac agg gac act gat  aag gtt att tgg        6096
Gly  Tyr Ala Ala Val Lys  Asn Arg Asp Thr Asp  Lys Val Ile Trp            
1520                 1525                 1530                            

gta  ccc tct cgg aaa gtt  aaa ccg gat gtc acc  caa aag gat gag        6141
Val  Pro Ser Arg Lys Val  Lys Pro Asp Val Thr  Gln Lys Asp Glu            
1535                 1540                 1545                            

gtg  act aag aaa gat gag  gcg agc cct ctt ttt  gca ggc att tct        6186
Val  Thr Lys Lys Asp Glu  Ala Ser Pro Leu Phe  Ala Gly Ile Ser            
1550                 1555                 1560                            

gac  tgg ata ccc tgg gaa  gac gag caa gaa gga  ctc caa gga gaa        6231
Asp  Trp Ile Pro Trp Glu  Asp Glu Gln Glu Gly  Leu Gln Gly Glu            
1565                 1570                 1575                            

acc  gct agc aac aag caa  gaa aga ccc gga gaa  gac acc ctt gct        6276
Thr  Ala Ser Asn Lys Gln  Glu Arg Pro Gly Glu  Asp Thr Leu Ala            
1580                 1585                 1590                            

gcc  aac gag agt taa gaattctgca gatatccagc acagtggcgg ccgctcgagt      6331
Ala  Asn Glu Ser                                                          
1595                                                                      

ctagagggcc cgtttaaacc cgctgatcag cctcgactgt gccttctagt tgccagccat     6391

ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc     6451

tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg     6511

ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg     6571

gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc tctagggggt     6631

atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     6691

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     6751

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     6811

gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta     6871

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     6931

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg     6991

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     7051

aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg     7111

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg     7171

aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc     7231

aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca     7291

ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg ccgcctctgc     7351

ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa     7411

gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat gaggatcgtt     7471

tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg tggagaggct     7531

attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg tgttccggct     7591

gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg ccctgaatga     7651

actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc cttgcgcagc     7711

tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg aagtgccggg     7771

gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca tggctgatgc     7831

aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc aagcgaaaca     7891

tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg atgatctgga     7951

cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg cgcgcatgcc     8011

cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata tcatggtgga     8071

aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg accgctatca     8131

ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat gggctgaccg     8191

cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct     8251

tcttgacgag ttcttctgag cgggactctg gggttcgaaa tgaccgacca agcgacgccc     8311

aacctgccat cacgagattt cgattccacc gccgccttct atgaaaggtt gggcttcgga     8371

atcgttttcc gggacgccgg ctggatgatc ctccagcgcg gggatctcat gctggagttc     8431

ttcgcccacc ccaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc     8491

acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc     8551

atcaatgtat cttatcatgt ctgtataccg tcgacctcta gctagagctt ggcgtaatca     8611

tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga     8671

gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt     8731

gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga     8791

atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc     8851

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     8911

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     8971

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     9031

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     9091

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     9151

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     9211

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     9271

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     9331

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     9391

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     9451

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     9511

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtttttttgt ttgcaagcag     9571

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     9631

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     9691

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     9751

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc     9811

tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg     9871

gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct     9931

ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca     9991

actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg    10051

ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg    10111

tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc    10171

cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag    10231

ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg    10291

ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag    10351

tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat    10411

agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg    10471

atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca    10531

gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca    10591

aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat    10651

tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag    10711

aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgtc       10768


<210>  12
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Glu Ala Val Ile Lys Val Ile Ser Ser Ala Cys Lys Thr Tyr Cys 
1               5                   10                  15      


Gly Lys Ile Ser Pro Ser Lys Lys Glu Ile Gly Ala Met Leu Ser Leu 
            20                  25                  30          


Leu Gln Lys Glu Gly Leu Leu Met Ser Pro Ser Asp Leu Tyr Ser Pro 
        35                  40                  45              


Gly Ser Trp Asp Pro Ile Thr Ala Ala Leu Ser Gln Arg Ala Met Val 
    50                  55                  60                  


Leu Gly Lys Ser Gly Glu Leu Lys Thr Trp Gly Leu Val Leu Gly Ala 
65                  70                  75                  80  


Leu Lys Ala Ala Arg Glu Glu Gln Val Thr Ser Glu Gln Ala Lys Phe 
                85                  90                  95      


Trp Leu Gly Leu Gly Gly Gly Arg Val Ser Pro Pro Gly Pro Glu Cys 
            100                 105                 110         


Ile Glu Lys Pro Ala Thr Glu Arg Arg Ile Asp Lys Gly Glu Glu Val 
        115                 120                 125             


Gly Glu Thr Thr Val Gln Arg Asp Ala Lys Met Ala Pro Glu Glu Ala 
    130                 135                 140                 


Ala Thr Pro Lys Thr Val Gly Thr Ser Cys Tyr His Cys Gly Thr Ala 
145                 150                 155                 160 


Val Gly Cys Asn Cys Ala Thr Ala Thr Ala Ser Ala Pro Pro Pro Pro 
                165                 170                 175     


Tyr Val Gly Ser Gly Leu Tyr Pro Ser Leu Ala Gly Val Gly Glu Gln 
            180                 185                 190         


Gln Gly Gln Gly Asp Asn Thr Ser Arg Gly Ala Glu Gln Pro Arg Glu 
        195                 200                 205             


Glu Pro Gly His Ala Gly Gln Ala Pro Gly Pro Ala Leu Thr Asp Trp 
    210                 215                 220                 


Ala Arg Val Arg Glu Glu Leu Ala Ser Thr Gly Pro Pro Val Val Ala 
225                 230                 235                 240 


Met Pro Val Val Ile Lys Thr Glu Gly Pro Ala Trp Thr Pro Leu Glu 
                245                 250                 255     


Pro Lys Leu Ile Thr Arg Leu Ala Asp Thr Val Arg Thr Lys Gly Leu 
            260                 265                 270         


Arg Ser Pro Ile Thr Met Ala Glu Val Glu Ala Leu Met Ser Ser Pro 
        275                 280                 285             


Leu Leu Pro His Asp Val Thr Asn Leu Met Arg Val Ile Leu Gly Pro 
    290                 295                 300                 


Ala Pro Tyr Ala Leu Trp Met Asp Ala Trp Gly Val Gln Leu Gln Thr 
305                 310                 315                 320 


Val Ile Ala Ala Ala Thr Arg Asp Pro Arg His Pro Ala Asn Gly Gln 
                325                 330                 335     


Gly Arg Gly Glu Arg Thr Asn Leu Asp Arg Leu Lys Gly Leu Ala Asp 
            340                 345                 350         


Gly Met Val Gly Asn Pro Gln Gly Gln Ala Ala Leu Leu Arg Pro Gly 
        355                 360                 365             


Glu Leu Val Ala Ile Thr Ala Ser Ala Leu Gln Ala Phe Arg Glu Val 
    370                 375                 380                 


Ala Arg Leu Ala Glu Pro Ala Gly Pro Trp Ala Asp Ile Thr Gln Gly 
385                 390                 395                 400 


Pro Ser Glu Ser Phe Val Asp Phe Ala Asn Arg Leu Ile Lys Ala Val 
                405                 410                 415     


Glu Gly Ser Asp Leu Pro Pro Ser Ala Arg Ala Pro Val Ile Ile Asp 
            420                 425                 430         


Cys Phe Arg Gln Lys Ser Gln Pro Asp Ile Gln Gln Leu Ile Arg Ala 
        435                 440                 445             


Ala Pro Ser Thr Leu Thr Thr Pro Gly Glu Ile Ile Lys Tyr Val Leu 
    450                 455                 460                 


Asp Arg Gln Lys Ile Ala Pro Leu Thr Asp Gln Gly Ile Ala Ala Ala 
465                 470                 475                 480 


Met Ser Ser Ala Ile Gln Pro Leu Val Met Ala Val Val Asn Arg Glu 
                485                 490                 495     


Arg Asp Gly Gln Thr Gly Ser Gly Gly Arg Ala Arg Gly Leu Cys Tyr 
            500                 505                 510         


Thr Cys Gly Ser Pro Gly His Tyr Gln Ala Gln Cys Pro Lys Lys Arg 
        515                 520                 525             


Lys Ser Gly Asn Ser Arg Glu Arg Cys Gln Leu Cys Asp Gly Met Gly 
    530                 535                 540                 


His Asn Ala Lys Gln Cys Arg Lys Arg Asp Gly Asn Gln Gly Gln Arg 
545                 550                 555                 560 


Pro Gly Arg Gly Leu Ser Ser Gly Pro Trp Pro Gly Pro Glu Gln Pro 
                565                 570                 575     


Ala Val Ser Leu Ala Met Thr Met Glu His Lys Asp Arg Pro Leu Val 
            580                 585                 590         


Arg Val Ile Leu Thr Asn Thr Gly Ser His Pro Val Lys Gln Arg Ser 
        595                 600                 605             


Val Tyr Ile Thr Ala Leu Leu Asp Ser Gly Ala Asp Ile Thr Ile Ile 
    610                 615                 620                 


Ser Glu Glu Asp Trp Pro Thr Asp Trp Pro Val Val Asp Thr Ala Asn 
625                 630                 635                 640 


Pro Gln Ile His Gly Ile Gly Gly Gly Ile Pro Met Arg Lys Ser Arg 
                645                 650                 655     


Asp Met Ile Glu Val Gly Val Ile Asn Arg Asp Gly Ser Leu Glu Arg 
            660                 665                 670         


Pro Leu Leu Leu Phe Pro Ala Val Ala Met Val Arg Gly Ser Ile Leu 
        675                 680                 685             


Gly Arg Asp Cys Leu Gln Gly Leu Gly Leu Arg Leu Thr Asn Leu 
    690                 695                 700             


<210>  13
<211>  895
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Thr Val Ala Leu His Leu Ala Ile Pro Leu Lys Trp Lys Ser Asp Arg 
1               5                   10                  15      


Thr Pro Val Trp Ile Asp Gln Trp Pro Leu Pro Glu Gly Lys Leu Val 
            20                  25                  30          


Ala Leu Thr Gln Leu Val Glu Lys Glu Leu Gln Leu Gly His Ile Glu 
        35                  40                  45              


Pro Ser Leu Ser Cys Trp Asn Thr Pro Val Phe Val Ile Arg Lys Ala 
    50                  55                  60                  


Ser Gly Ser Tyr Arg Leu Leu His Asp Leu Arg Ala Val Asn Ala Lys 
65                  70                  75                  80  


Leu Val Pro Phe Gly Ala Val Gln Gln Gly Ala Pro Val Leu Ser Ala 
                85                  90                  95      


Leu Pro Arg Gly Trp Pro Leu Met Val Leu Asp Leu Lys Asp Cys Phe 
            100                 105                 110         


Phe Ser Ile Pro Leu Ala Glu Gln Asp Arg Glu Ala Phe Ala Phe Thr 
        115                 120                 125             


Leu Pro Ser Val Asn Asn Gln Ala Pro Ala Arg Arg Phe Gln Trp Lys 
    130                 135                 140                 


Val Leu Pro Gln Gly Met Thr Cys Ser Pro Thr Ile Cys Gln Leu Val 
145                 150                 155                 160 


Val Gly Gln Val Leu Glu Pro Leu Arg Leu Lys His Pro Ala Leu Arg 
                165                 170                 175     


Met Leu His Tyr Met Asp Asp Leu Leu Leu Ala Ala Ser Ser His Asp 
            180                 185                 190         


Gly Leu Glu Ala Ala Gly Lys Glu Val Ile Gly Thr Leu Glu Arg Ala 
        195                 200                 205             


Gly Phe Thr Ile Ser Pro Asp Lys Ile Gln Arg Glu Pro Gly Val Gln 
    210                 215                 220                 


Tyr Leu Gly Tyr Lys Leu Gly Ser Thr Tyr Val Ala Pro Val Gly Leu 
225                 230                 235                 240 


Val Ala Glu Pro Arg Ile Ala Thr Leu Trp Asp Val Gln Lys Leu Val 
                245                 250                 255     


Gly Ser Leu Gln Trp Leu Arg Pro Ala Leu Gly Ile Pro Pro Arg Leu 
            260                 265                 270         


Met Gly Pro Phe Tyr Glu Gln Leu Arg Gly Ser Asp Pro Asn Glu Ala 
        275                 280                 285             


Arg Glu Trp Asn Leu Asp Met Lys Met Ala Trp Arg Glu Ile Val Gln 
    290                 295                 300                 


Leu Ser Thr Thr Ala Ala Leu Glu Arg Trp Asp Pro Ala Gln Pro Leu 
305                 310                 315                 320 


Glu Gly Ala Val Ala Arg Cys Glu Gln Gly Ala Ile Gly Val Leu Gly 
                325                 330                 335     


Gln Gly Leu Ser Thr His Pro Arg Pro Cys Leu Trp Leu Phe Ser Thr 
            340                 345                 350         


Gln Pro Thr Lys Ala Phe Thr Ala Trp Leu Glu Val Leu Thr Leu Leu 
        355                 360                 365             


Ile Thr Lys Leu Arg Ala Ser Ala Val Arg Thr Phe Gly Lys Glu Val 
    370                 375                 380                 


Asp Ile Leu Leu Leu Pro Ala Cys Phe Arg Glu Asp Leu Pro Leu Pro 
385                 390                 395                 400 


Glu Gly Ile Leu Leu Ala Leu Arg Gly Phe Ala Gly Lys Ile Arg Ser 
                405                 410                 415     


Ser Asp Thr Pro Ser Ile Phe Asp Ile Ala Arg Pro Leu His Val Ser 
            420                 425                 430         


Leu Lys Val Arg Val Thr Asp His Pro Val Pro Gly Pro Thr Val Phe 
        435                 440                 445             


Thr Asp Ala Ser Ser Ser Thr His Lys Gly Val Val Val Trp Arg Glu 
    450                 455                 460                 


Gly Pro Arg Trp Glu Ile Lys Glu Ile Val Asp Leu Gly Ala Ser Val 
465                 470                 475                 480 


Gln Gln Leu Glu Ala Arg Ala Val Ala Met Ala Leu Leu Leu Trp Pro 
                485                 490                 495     


Thr Thr Pro Thr Asn Val Val Thr Asp Ser Ala Phe Val Ala Lys Met 
            500                 505                 510         


Leu Leu Lys Met Gly Gln Glu Gly Val Pro Ser Thr Ala Ala Ala Phe 
        515                 520                 525             


Ile Leu Glu Asp Ala Leu Ser Gln Arg Ser Ala Met Ala Ala Val Leu 
    530                 535                 540                 


His Val Arg Ser His Ser Glu Val Pro Gly Phe Phe Thr Glu Gly Asn 
545                 550                 555                 560 


Asp Val Ala Asp Ser Gln Ala Thr Phe Gln Ala Tyr Pro Leu Arg Glu 
                565                 570                 575     


Ala Lys Asp Leu His Thr Ala Leu His Ile Gly Pro Arg Ala Leu Ser 
            580                 585                 590         


Lys Ala Cys Asn Ile Ser Met Gln Gln Ala Arg Glu Val Val Gln Thr 
        595                 600                 605             


Cys Pro His Cys Asn Ser Ala Pro Ala Leu Glu Ala Gly Val Asn Pro 
    610                 615                 620                 


Arg Gly Leu Gly Pro Leu Gln Ile Trp Gln Thr Asp Phe Thr Leu Glu 
625                 630                 635                 640 


Pro Arg Met Ala Pro Arg Ser Trp Leu Ala Val Thr Val Asp Thr Ala 
                645                 650                 655     


Ser Ser Ala Ile Val Val Thr Gln His Gly Arg Val Thr Ser Val Ala 
            660                 665                 670         


Ala Gln His His Trp Ala Thr Ala Ile Ala Val Leu Gly Arg Pro Lys 
        675                 680                 685             


Ala Ile Lys Thr Asp Asn Gly Ser Cys Phe Thr Ser Arg Ser Thr Arg 
    690                 695                 700                 


Glu Trp Leu Ala Arg Trp Gly Ile Ala His Thr Thr Gly Ile Pro Gly 
705                 710                 715                 720 


Asn Ser Gln Gly Gln Ala Met Val Glu Arg Ala Asn Arg Leu Leu Lys 
                725                 730                 735     


Asp Lys Ile Arg Val Leu Ala Glu Gly Asp Gly Phe Met Lys Arg Ile 
            740                 745                 750         


Pro Ala Ser Lys Gln Gly Glu Leu Leu Ala Lys Ala Met Tyr Ala Leu 
        755                 760                 765             


Asn His Phe Glu Arg Gly Glu Asn Thr Lys Thr Pro Val Gln Lys His 
    770                 775                 780                 


Trp Arg Pro Thr Val Leu Thr Glu Gly Pro Pro Val Lys Ile Arg Ile 
785                 790                 795                 800 


Glu Thr Gly Glu Trp Glu Lys Gly Trp Asn Val Leu Val Trp Gly Arg 
                805                 810                 815     


Gly Tyr Ala Ala Val Lys Asn Arg Asp Thr Asp Lys Val Ile Trp Val 
            820                 825                 830         


Pro Ser Arg Lys Val Lys Pro Asp Val Thr Gln Lys Asp Glu Val Thr 
        835                 840                 845             


Lys Lys Asp Glu Ala Ser Pro Leu Phe Ala Gly Ile Ser Asp Trp Ile 
    850                 855                 860                 


Pro Trp Glu Asp Glu Gln Glu Gly Leu Gln Gly Glu Thr Ala Ser Asn 
865                 870                 875                 880 


Lys Gln Glu Arg Pro Gly Glu Asp Thr Leu Ala Ala Asn Glu Ser 
                885                 890                 895 


<210>  14
<211>  10768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Seq.-ID Nr. 14: 1. Helferplasmid fr kodonoptimiertes 
       gag-pol "


<220>
<221>  promoter
<222>  (232)..(819)
<223>  Promoter von CMV

<220>
<221>  Intron
<222>  (907)..(1463)
<223>  Intron von beta Globin

<220>
<221>  CDS
<222>  (1475)..(3586)
<223>  gal: Kodierende Sequenz fr Gal, kodonoptimiert

<220>
<221>  misc_feature
<222>  (3437)..(3737)
<223>  bergangsbereich zwischen fr gag und pol kodierenden Bereichen 
       (Wildtyp)

<220>
<221>  misc_feature
<222>  (3574)..(3723)
<223>  Signal fr nderung des Leserahmens (frameshift signal)

<220>
<221>  CDS
<222>  (3604)..(6291)
<223>  pol: Kodierende Sequenz fr Pol, kodonoptimiert

<220>
<221>  polyA_signal
<222>  (6368)..(6588)
<223>  poly Adenylierungssignal aus bGH

<400>  14
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cctgagaact tcagggtgag tctatgggac ccttgatgtt ttctttcccc      960

ttcttttcta tggttaagtt catgtcatag gaaggggaga agtaacaggg tacacatatt     1020

gaccaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata     1080

cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag ggcaataatg     1140

atacaatgta tcatgcctct ttgcaccatt ctaaagaata acagtgataa tttctgggtt     1200

aaggcaatag caatatttct gcatataaat atttctgcat ataaattgta actgatgtaa     1260

gaggtttcat attgctaata gcagctacaa tccagctacc attctgcttt tattttatgg     1320

ttgggataag gctggattat tctgagtcca agctaggccc ttttgctaat catgttcata     1380

cctcttatct tcctcccaca gctcctgggc aacgtgctgg tctgtgtgct ggcccatcac     1440

tttggcaaag cacgtgagat ctgaattcgc cacc atg gaa gcc gtg atc aaa gtg     1495
                                      Met Glu Ala Val Ile Lys Val         
                                      1               5                   

atc agc agc gcc tgc aag acc tac tgc ggc aag atc agc ccc agc aag       1543
Ile Ser Ser Ala Cys Lys Thr Tyr Cys Gly Lys Ile Ser Pro Ser Lys           
        10                  15                  20                        

aaa gaa atc ggc gct atg ctg tct ctc ctg caa aag gaa ggc ctg ctg       1591
Lys Glu Ile Gly Ala Met Leu Ser Leu Leu Gln Lys Glu Gly Leu Leu           
    25                  30                  35                            

atg agc ccc agc gac ctg tac agc ccc ggc agc tgg gat cct atc aca       1639
Met Ser Pro Ser Asp Leu Tyr Ser Pro Gly Ser Trp Asp Pro Ile Thr           
40                  45                  50                  55            

gcc gcc ctg agc cag agg gcc atg gtg ctg ggc aag agc ggc gag ctg       1687
Ala Ala Leu Ser Gln Arg Ala Met Val Leu Gly Lys Ser Gly Glu Leu           
                60                  65                  70                

aaa acc tgg ggg ctg gtg ctg gga gcc ctg aag gcc gcc aga gaa gaa       1735
Lys Thr Trp Gly Leu Val Leu Gly Ala Leu Lys Ala Ala Arg Glu Glu           
            75                  80                  85                    

cag gtg acc agc gag cag gcc aag ttt tgg ctg ggc ctg ggc gga gga       1783
Gln Val Thr Ser Glu Gln Ala Lys Phe Trp Leu Gly Leu Gly Gly Gly           
        90                  95                  100                       

aga gtg tct ccc cct ggc ccc gag tgt atc gag aag ccc gcc acc gag       1831
Arg Val Ser Pro Pro Gly Pro Glu Cys Ile Glu Lys Pro Ala Thr Glu           
    105                 110                 115                           

cgg aga atc gac aag ggc gag gaa gtg ggc gag aca acc gtg cag cgg       1879
Arg Arg Ile Asp Lys Gly Glu Glu Val Gly Glu Thr Thr Val Gln Arg           
120                 125                 130                 135           

gac gcc aag atg gcc cct gag gaa gcc gcc acc cct aag acc gtg ggc       1927
Asp Ala Lys Met Ala Pro Glu Glu Ala Ala Thr Pro Lys Thr Val Gly           
                140                 145                 150               

acc agc tgc tac cac tgt ggc acc gcc gtg ggc tgt aat tgt gcc acc       1975
Thr Ser Cys Tyr His Cys Gly Thr Ala Val Gly Cys Asn Cys Ala Thr           
            155                 160                 165                   

gcc acc gcc tct gcc cct cct cct cct tac gtg ggc agc ggc ctg tat       2023
Ala Thr Ala Ser Ala Pro Pro Pro Pro Tyr Val Gly Ser Gly Leu Tyr           
        170                 175                 180                       

cct tct ctg gcc ggc gtg ggc gag cag cag gga cag ggc gac aat acc       2071
Pro Ser Leu Ala Gly Val Gly Glu Gln Gln Gly Gln Gly Asp Asn Thr           
    185                 190                 195                           

agc aga ggc gcc gag cag cct aga gag gaa cct gga cac gct ggc cag       2119
Ser Arg Gly Ala Glu Gln Pro Arg Glu Glu Pro Gly His Ala Gly Gln           
200                 205                 210                 215           

gcc cca gga cct gcc ctg aca gat tgg gcc aga gtg cgg gag gaa ctg       2167
Ala Pro Gly Pro Ala Leu Thr Asp Trp Ala Arg Val Arg Glu Glu Leu           
                220                 225                 230               

gcc tct acc gga ccc cct gtg gtg gcc atg ccc gtg gtg atc aag aca       2215
Ala Ser Thr Gly Pro Pro Val Val Ala Met Pro Val Val Ile Lys Thr           
            235                 240                 245                   

gag ggc cct gcc tgg acc cct ctg gaa ccc aag ctg atc acc cgg ctg       2263
Glu Gly Pro Ala Trp Thr Pro Leu Glu Pro Lys Leu Ile Thr Arg Leu           
        250                 255                 260                       

gcc gat aca gtg cgg acc aag ggc ctg aga agc ccc atc acc atg gcc       2311
Ala Asp Thr Val Arg Thr Lys Gly Leu Arg Ser Pro Ile Thr Met Ala           
    265                 270                 275                           

gag gtg gag gcc ctg atg agc agc ccc ctg ctg ccc cac gac gtg acc       2359
Glu Val Glu Ala Leu Met Ser Ser Pro Leu Leu Pro His Asp Val Thr           
280                 285                 290                 295           

aac ctg atg aga gtg atc ctg ggc cct gct ccc tac gcc ctg tgg atg       2407
Asn Leu Met Arg Val Ile Leu Gly Pro Ala Pro Tyr Ala Leu Trp Met           
                300                 305                 310               

gat gcc tgg ggc gtg cag ctg cag aca gtg atc gcc gct gcc acc aga       2455
Asp Ala Trp Gly Val Gln Leu Gln Thr Val Ile Ala Ala Ala Thr Arg           
            315                 320                 325                   

gat ccc aga cac ccc gcc aat ggc cag ggc aga ggc gag cgg acc aac       2503
Asp Pro Arg His Pro Ala Asn Gly Gln Gly Arg Gly Glu Arg Thr Asn           
        330                 335                 340                       

ctg gac aga ctg aag ggc ctg gcc gac ggc atg gtg ggc aat cct cag       2551
Leu Asp Arg Leu Lys Gly Leu Ala Asp Gly Met Val Gly Asn Pro Gln           
    345                 350                 355                           

gga cag gcc gct ctg ctg agg cct ggc gaa ctg gtg gcc atc aca gcc       2599
Gly Gln Ala Ala Leu Leu Arg Pro Gly Glu Leu Val Ala Ile Thr Ala           
360                 365                 370                 375           

agc gcc ctg cag gcc ttc aga gag gtg gcc aga ctg gcc gag cct gcc       2647
Ser Ala Leu Gln Ala Phe Arg Glu Val Ala Arg Leu Ala Glu Pro Ala           
                380                 385                 390               

ggc cct tgg gcc gat atc acc cag ggc ccc agc gag agc ttc gtg gac       2695
Gly Pro Trp Ala Asp Ile Thr Gln Gly Pro Ser Glu Ser Phe Val Asp           
            395                 400                 405                   

ttc gcc aac cgg ctg atc aag gcc gtg gag ggc agc gat ctg cct cct       2743
Phe Ala Asn Arg Leu Ile Lys Ala Val Glu Gly Ser Asp Leu Pro Pro           
        410                 415                 420                       

agc gcc aga gcc ccc gtg atc atc gac tgc ttc cgg cag aag tcc cag       2791
Ser Ala Arg Ala Pro Val Ile Ile Asp Cys Phe Arg Gln Lys Ser Gln           
    425                 430                 435                           

ccc gac atc cag cag ctg atc aga gcc gcc cct agc acc ctg acc acc       2839
Pro Asp Ile Gln Gln Leu Ile Arg Ala Ala Pro Ser Thr Leu Thr Thr           
440                 445                 450                 455           

cct ggc gag atc atc aaa tac gtg ctg gac cgg cag aag atc gcc cct       2887
Pro Gly Glu Ile Ile Lys Tyr Val Leu Asp Arg Gln Lys Ile Ala Pro           
                460                 465                 470               

ctg acc gat cag ggc att gcc gcc gct atg agc agc gcc atc cag cct       2935
Leu Thr Asp Gln Gly Ile Ala Ala Ala Met Ser Ser Ala Ile Gln Pro           
            475                 480                 485                   

ctg gtg atg gcc gtg gtg aac aga gag agg gac ggc cag aca gga tct       2983
Leu Val Met Ala Val Val Asn Arg Glu Arg Asp Gly Gln Thr Gly Ser           
        490                 495                 500                       

ggc ggc aga gcc aga ggc ctg tgc tac acc tgt ggc agc cct ggc cac       3031
Gly Gly Arg Ala Arg Gly Leu Cys Tyr Thr Cys Gly Ser Pro Gly His           
    505                 510                 515                           

tac cag gcc cag tgc ccc aag aag cgg aag tcc ggc aac agc cgg gag       3079
Tyr Gln Ala Gln Cys Pro Lys Lys Arg Lys Ser Gly Asn Ser Arg Glu           
520                 525                 530                 535           

aga tgc cag ctg tgt gac ggc atg ggc cac aac gcc aag cag tgc cgg       3127
Arg Cys Gln Leu Cys Asp Gly Met Gly His Asn Ala Lys Gln Cys Arg           
                540                 545                 550               

aag cgg gat ggc aat cag ggc cag agg ccc ggc aga gga ctg tct agc       3175
Lys Arg Asp Gly Asn Gln Gly Gln Arg Pro Gly Arg Gly Leu Ser Ser           
            555                 560                 565                   

ggc cct tgg cct gga cct gag cag cct gcc gtg agc ctg gcc atg acc       3223
Gly Pro Trp Pro Gly Pro Glu Gln Pro Ala Val Ser Leu Ala Met Thr           
        570                 575                 580                       

atg gaa cac aag gac cgg ccc ctg gtg cgc gtg atc ctg acc aac acc       3271
Met Glu His Lys Asp Arg Pro Leu Val Arg Val Ile Leu Thr Asn Thr           
    585                 590                 595                           

ggc agc cac ccc gtg aag cag cgg agc gtg tac atc acc gcc ctg ctg       3319
Gly Ser His Pro Val Lys Gln Arg Ser Val Tyr Ile Thr Ala Leu Leu           
600                 605                 610                 615           

gac agc gga gcc gac atc acc atc atc agc gaa gag gac tgg ccc acc       3367
Asp Ser Gly Ala Asp Ile Thr Ile Ile Ser Glu Glu Asp Trp Pro Thr           
                620                 625                 630               

gac tgg cct gtg gtg gac acc gcc aac ccc cag atc cac ggc atc ggc       3415
Asp Trp Pro Val Val Asp Thr Ala Asn Pro Gln Ile His Gly Ile Gly           
            635                 640                 645                   

gga gga atc ccc atg cgg aag tcc cgg gat atg ata gag gtg ggg gtt       3463
Gly Gly Ile Pro Met Arg Lys Ser Arg Asp Met Ile Glu Val Gly Val           
        650                 655                 660                       

att aac cga gac ggg tcg ttg gag cga ccc ctg ctc ctc ttc ccc gca       3511
Ile Asn Arg Asp Gly Ser Leu Glu Arg Pro Leu Leu Leu Phe Pro Ala           
    665                 670                 675                           

gtc gct atg gtt aga ggg agt atc cta gga aga gat tgt ctg cag ggc       3559
Val Ala Met Val Arg Gly Ser Ile Leu Gly Arg Asp Cys Leu Gln Gly           
680                 685                 690                 695           

cta ggg ctc cgc ttg aca aat tta tag ggagggccac tgttctt act gtt        3609
Leu Gly Leu Arg Leu Thr Asn Leu                        Thr Val            
                700                                        705            

gcg cta cat ctg gct att ccg ctc aaa tgg aag tca gac cgc acg cct       3657
Ala Leu His Leu Ala Ile Pro Leu Lys Trp Lys Ser Asp Arg Thr Pro           
                710                 715                 720               

gtg tgg att gac cag tgg ccc ctt cct gaa ggt aaa ctt gta gcg cta       3705
Val Trp Ile Asp Gln Trp Pro Leu Pro Glu Gly Lys Leu Val Ala Leu           
            725                 730                 735                   

acg caa tta gtg gaa aaa gaa tta cag tta ggc cac atc gag ccc agc       3753
Thr Gln Leu Val Glu Lys Glu Leu Gln Leu Gly His Ile Glu Pro Ser           
        740                 745                 750                       

ctg agc tgc tgg aac acc ccc gtg ttc gtg atc aga aag gcc agc ggc       3801
Leu Ser Cys Trp Asn Thr Pro Val Phe Val Ile Arg Lys Ala Ser Gly           
    755                 760                 765                           

agc tac aga ctg ctg cac gac ctg cgg gcc gtg aat gcc aag ctg gtg       3849
Ser Tyr Arg Leu Leu His Asp Leu Arg Ala Val Asn Ala Lys Leu Val           
770                 775                 780                 785           

ccc ttt ggc gcc gtg cag cag ggc gct cct gtg ctg tct gcc ctg cca       3897
Pro Phe Gly Ala Val Gln Gln Gly Ala Pro Val Leu Ser Ala Leu Pro           
                790                 795                 800               

aga gga tgg ccc ctg atg gtg ctg gac ctg aag gac tgc ttc ttc agc       3945
Arg Gly Trp Pro Leu Met Val Leu Asp Leu Lys Asp Cys Phe Phe Ser           
            805                 810                 815                   

atc cct ctg gcc gag cag gac aga gag gcc ttc gcc ttc acc ctg cct       3993
Ile Pro Leu Ala Glu Gln Asp Arg Glu Ala Phe Ala Phe Thr Leu Pro           
        820                 825                 830                       

agc gtg aac aac cag gcc cca gcc aga cgg ttc cag tgg aag gtg ctg       4041
Ser Val Asn Asn Gln Ala Pro Ala Arg Arg Phe Gln Trp Lys Val Leu           
    835                 840                 845                           

ccc cag ggc atg acc tgc agc ccc acc atc tgt cag ctg gtc gtg gga       4089
Pro Gln Gly Met Thr Cys Ser Pro Thr Ile Cys Gln Leu Val Val Gly           
850                 855                 860                 865           

cag gtg ctg gaa ccc ctg aga ctg aag cac ccc gcc ctg cgg atg ctg       4137
Gln Val Leu Glu Pro Leu Arg Leu Lys His Pro Ala Leu Arg Met Leu           
                870                 875                 880               

cac tac atg gac gac ctg ctc ctc gcc gct tct agc cac gac ggc ctg       4185
His Tyr Met Asp Asp Leu Leu Leu Ala Ala Ser Ser His Asp Gly Leu           
            885                 890                 895                   

gaa gcc gcc gga aaa gaa gtg atc ggc acc ctg gaa aga gcc ggc ttc       4233
Glu Ala Ala Gly Lys Glu Val Ile Gly Thr Leu Glu Arg Ala Gly Phe           
        900                 905                 910                       

acc atc agc ccc gac aag atc cag agg gaa ccc ggc gtg cag tac ctg       4281
Thr Ile Ser Pro Asp Lys Ile Gln Arg Glu Pro Gly Val Gln Tyr Leu           
    915                 920                 925                           

ggc tac aag ctg ggc agc acc tat gtg gcc cct gtg ggc ctg gtg gcc       4329
Gly Tyr Lys Leu Gly Ser Thr Tyr Val Ala Pro Val Gly Leu Val Ala           
930                 935                 940                 945           

gag cca aga atc gcc acc ctg tgg gac gtg cag aaa ctg gtg ggc agc       4377
Glu Pro Arg Ile Ala Thr Leu Trp Asp Val Gln Lys Leu Val Gly Ser           
                950                 955                 960               

ctg cag tgg ctg agg cca gcc ctg ggc atc cct ccc aga ctg atg ggc       4425
Leu Gln Trp Leu Arg Pro Ala Leu Gly Ile Pro Pro Arg Leu Met Gly           
            965                 970                 975                   

ccc ttc tac gag cag ctg cgg ggc tcc gac cct aat gag gcc cgg gag       4473
Pro Phe Tyr Glu Gln Leu Arg Gly Ser Asp Pro Asn Glu Ala Arg Glu           
        980                 985                 990                       

tgg aac ctg gat atg aag atg  gcc tgg cgg gag atc  gtg cag ctg tcc     4521
Trp Asn Leu Asp Met Lys Met  Ala Trp Arg Glu Ile  Val Gln Leu Ser         
    995                 1000                 1005                         

acc  act gcc gcc ctg gaa  cgc tgg gat cca gca  cag cca ctc gaa        4566
Thr  Thr Ala Ala Leu Glu  Arg Trp Asp Pro Ala  Gln Pro Leu Glu            
1010                 1015                 1020                            

ggt  gcc gtg gcc aga tgt  gaa cag ggc gcc atc  ggc gtg ctg ggc        4611
Gly  Ala Val Ala Arg Cys  Glu Gln Gly Ala Ile  Gly Val Leu Gly            
1025                 1030                 1035                            

cag  gga ctg agc acc cac  ccc aga ccc tgc ctg  tgg ctg ttc agc        4656
Gln  Gly Leu Ser Thr His  Pro Arg Pro Cys Leu  Trp Leu Phe Ser            
1040                 1045                 1050                            

acc  cag ccc acc aag gcc  ttc acc gcc tgg ctg  gaa gtg ctg acc        4701
Thr  Gln Pro Thr Lys Ala  Phe Thr Ala Trp Leu  Glu Val Leu Thr            
1055                 1060                 1065                            

ctg  ctg atc acc aag ctg  cgg gcc agc gcc gtg  aga acc ttc ggc        4746
Leu  Leu Ile Thr Lys Leu  Arg Ala Ser Ala Val  Arg Thr Phe Gly            
1070                 1075                 1080                            

aaa  gag gtg gac atc ctg  ctg ctg cca gcc tgc  ttt aga gag gac        4791
Lys  Glu Val Asp Ile Leu  Leu Leu Pro Ala Cys  Phe Arg Glu Asp            
1085                 1090                 1095                            

ctg  ccc ctg cct gag gga  atc ctg ctg gcc ctg  aga ggc ttt gcc        4836
Leu  Pro Leu Pro Glu Gly  Ile Leu Leu Ala Leu  Arg Gly Phe Ala            
1100                 1105                 1110                            

ggc  aag atc cgg tcc agc  gac acc ccc agc atc  ttc gat atc gcc        4881
Gly  Lys Ile Arg Ser Ser  Asp Thr Pro Ser Ile  Phe Asp Ile Ala            
1115                 1120                 1125                            

aga  ccc ctg cac gtg tcc  ctg aaa gtg cgc gtg  acc gat cac cct        4926
Arg  Pro Leu His Val Ser  Leu Lys Val Arg Val  Thr Asp His Pro            
1130                 1135                 1140                            

gtg  cct ggc ccc acc gtg  ttt acc gac gcc agc  agc agc acc cac        4971
Val  Pro Gly Pro Thr Val  Phe Thr Asp Ala Ser  Ser Ser Thr His            
1145                 1150                 1155                            

aag  ggc gtg gtg gtg tgg  aga gaa ggc ccc aga  tgg gag atc aaa        5016
Lys  Gly Val Val Val Trp  Arg Glu Gly Pro Arg  Trp Glu Ile Lys            
1160                 1165                 1170                            

gaa  atc gtg gac ctg ggc  gcc tct gtg cag cag  ctg gaa gcc aga        5061
Glu  Ile Val Asp Leu Gly  Ala Ser Val Gln Gln  Leu Glu Ala Arg            
1175                 1180                 1185                            

gcc  gtg gcc atg gct ctg  ctg ctg tgg ccc acc  acc ccc acc aac        5106
Ala  Val Ala Met Ala Leu  Leu Leu Trp Pro Thr  Thr Pro Thr Asn            
1190                 1195                 1200                            

gtg  gtg acc gac agc gcc  ttc gtg gcc aag atg  ctg ctg aag atg        5151
Val  Val Thr Asp Ser Ala  Phe Val Ala Lys Met  Leu Leu Lys Met            
1205                 1210                 1215                            

ggc  cag gaa ggc gtc cct  agc acc gcc gct gcc  ttc atc ctg gaa        5196
Gly  Gln Glu Gly Val Pro  Ser Thr Ala Ala Ala  Phe Ile Leu Glu            
1220                 1225                 1230                            

gat  gcc ctg tcc cag cgg  agc gct atg gct gct  gtg ctg cac gtg        5241
Asp  Ala Leu Ser Gln Arg  Ser Ala Met Ala Ala  Val Leu His Val            
1235                 1240                 1245                            

cgg  agc cac agc gag gtg  ccc ggc ttc ttc acc  gag ggc aac gac        5286
Arg  Ser His Ser Glu Val  Pro Gly Phe Phe Thr  Glu Gly Asn Asp            
1250                 1255                 1260                            

gtg  gcc gac agc cag gcc  acc ttc cag gcc tac  ccc ctg aga gag        5331
Val  Ala Asp Ser Gln Ala  Thr Phe Gln Ala Tyr  Pro Leu Arg Glu            
1265                 1270                 1275                            

gcc  aag gac ctg cac aca  gcc ctg cac atc ggc  ccc aga gcc ctg        5376
Ala  Lys Asp Leu His Thr  Ala Leu His Ile Gly  Pro Arg Ala Leu            
1280                 1285                 1290                            

agc  aag gcc tgc aac atc  agc atg cag cag gcc  aga gaa gtg gtg        5421
Ser  Lys Ala Cys Asn Ile  Ser Met Gln Gln Ala  Arg Glu Val Val            
1295                 1300                 1305                            

cag  acc tgt ccc cac tgt  aat agc gcc cct gct  ctg gaa gcc ggc        5466
Gln  Thr Cys Pro His Cys  Asn Ser Ala Pro Ala  Leu Glu Ala Gly            
1310                 1315                 1320                            

gtg  aac cct aga ggc ctc  ggc cct ctg cag atc  tgg cag acc gac        5511
Val  Asn Pro Arg Gly Leu  Gly Pro Leu Gln Ile  Trp Gln Thr Asp            
1325                 1330                 1335                            

ttc  acc ctg gaa ccc cgg  atg gcc cct aga agc  tgg ctg gcc gtg        5556
Phe  Thr Leu Glu Pro Arg  Met Ala Pro Arg Ser  Trp Leu Ala Val            
1340                 1345                 1350                            

acc  gtg gat acc gcc agc  tcc gcc atc gtg gtg  acc cag cac ggc        5601
Thr  Val Asp Thr Ala Ser  Ser Ala Ile Val Val  Thr Gln His Gly            
1355                 1360                 1365                            

aga  gtg aca tct gtg gcc  gcc cag cac cac tgg  gcc aca gcc att        5646
Arg  Val Thr Ser Val Ala  Ala Gln His His Trp  Ala Thr Ala Ile            
1370                 1375                 1380                            

gcc  gtg ctg ggc aga ccc  aag gcc atc aag acc  gac aac ggc agc        5691
Ala  Val Leu Gly Arg Pro  Lys Ala Ile Lys Thr  Asp Asn Gly Ser            
1385                 1390                 1395                            

tgc  ttc acc agc cgg tcc  acc aga gaa tgg ctg  gcc aga tgg ggc        5736
Cys  Phe Thr Ser Arg Ser  Thr Arg Glu Trp Leu  Ala Arg Trp Gly            
1400                 1405                 1410                            

att  gct cac acc acc ggc  atc cca ggc aat agt  cag ggc cag gcc        5781
Ile  Ala His Thr Thr Gly  Ile Pro Gly Asn Ser  Gln Gly Gln Ala            
1415                 1420                 1425                            

atg  gtg gag aga gcc aac  agg ctg ctg aag gac  aag atc cgg gtg        5826
Met  Val Glu Arg Ala Asn  Arg Leu Leu Lys Asp  Lys Ile Arg Val            
1430                 1435                 1440                            

ctg  gcc gag ggc gac ggc  ttc atg aag cgg atc  ccc gcc agc aaa        5871
Leu  Ala Glu Gly Asp Gly  Phe Met Lys Arg Ile  Pro Ala Ser Lys            
1445                 1450                 1455                            

cag  ggc gag ctg ctg gcc  aag gcc atg tac gcc  ctg aac cac ttc        5916
Gln  Gly Glu Leu Leu Ala  Lys Ala Met Tyr Ala  Leu Asn His Phe            
1460                 1465                 1470                            

gag  cgg ggc gag aac acc  aag acc ccc gtg cag  aag cac tgg cgg        5961
Glu  Arg Gly Glu Asn Thr  Lys Thr Pro Val Gln  Lys His Trp Arg            
1475                 1480                 1485                            

cct  acc gtg ctg aca gag  gga ccc ccc gtg aag  atc cgg atc gag        6006
Pro  Thr Val Leu Thr Glu  Gly Pro Pro Val Lys  Ile Arg Ile Glu            
1490                 1495                 1500                            

aca  ggc gag tgg gag aag  ggg tgg aac gtg ctg  gtg tgg ggc aga        6051
Thr  Gly Glu Trp Glu Lys  Gly Trp Asn Val Leu  Val Trp Gly Arg            
1505                 1510                 1515                            

ggc  tac gcc gct gtc aag  aac cgg gac acc gac  aaa gtg atc tgg        6096
Gly  Tyr Ala Ala Val Lys  Asn Arg Asp Thr Asp  Lys Val Ile Trp            
1520                 1525                 1530                            

gtg  ccc agc cgg aaa gtg  aag ccc gac gtg acc  cag aaa gac gaa        6141
Val  Pro Ser Arg Lys Val  Lys Pro Asp Val Thr  Gln Lys Asp Glu            
1535                 1540                 1545                            

gtg  acc aag aag gac gag  gcc tcc ccc ctc ttt  gcc ggc atc agc        6186
Val  Thr Lys Lys Asp Glu  Ala Ser Pro Leu Phe  Ala Gly Ile Ser            
1550                 1555                 1560                            

gac  tgg atc cct tgg gag  gac gag cag gaa ggc  ctg cag ggc gag        6231
Asp  Trp Ile Pro Trp Glu  Asp Glu Gln Glu Gly  Leu Gln Gly Glu            
1565                 1570                 1575                            

aca  gcc agc aac aag cag  gaa aga ccc ggc gag  gac acc ctg gcc        6276
Thr  Ala Ser Asn Lys Gln  Glu Arg Pro Gly Glu  Asp Thr Leu Ala            
1580                 1585                 1590                            

gcc  aat gag agc tga gaattctgca gatatccagc acagtggcgg ccgctcgagt      6331
Ala  Asn Glu Ser                                                          
1595                                                                      

ctagagggcc cgtttaaacc cgctgatcag cctcgactgt gccttctagt tgccagccat     6391

ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc     6451

tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg     6511

ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg     6571

gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc tctagggggt     6631

atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     6691

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     6751

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     6811

gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta     6871

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     6931

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg     6991

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     7051

aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg     7111

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg     7171

aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc     7231

aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca     7291

ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg ccgcctctgc     7351

ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa     7411

gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat gaggatcgtt     7471

tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg tggagaggct     7531

attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg tgttccggct     7591

gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg ccctgaatga     7651

actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc cttgcgcagc     7711

tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg aagtgccggg     7771

gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca tggctgatgc     7831

aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc aagcgaaaca     7891

tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg atgatctgga     7951

cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg cgcgcatgcc     8011

cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata tcatggtgga     8071

aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg accgctatca     8131

ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat gggctgaccg     8191

cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct     8251

tcttgacgag ttcttctgag cgggactctg gggttcgaaa tgaccgacca agcgacgccc     8311

aacctgccat cacgagattt cgattccacc gccgccttct atgaaaggtt gggcttcgga     8371

atcgttttcc gggacgccgg ctggatgatc ctccagcgcg gggatctcat gctggagttc     8431

ttcgcccacc ccaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc     8491

acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc     8551

atcaatgtat cttatcatgt ctgtataccg tcgacctcta gctagagctt ggcgtaatca     8611

tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga     8671

gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt     8731

gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga     8791

atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc     8851

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     8911

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     8971

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     9031

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     9091

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     9151

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     9211

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     9271

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     9331

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     9391

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     9451

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     9511

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtttttttgt ttgcaagcag     9571

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     9631

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     9691

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     9751

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc     9811

tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg     9871

gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct     9931

ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca     9991

actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg    10051

ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg    10111

tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc    10171

cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag    10231

ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg    10291

ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag    10351

tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat    10411

agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg    10471

atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca    10531

gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca    10591

aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat    10651

tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag    10711

aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgtc       10768


<210>  15
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Met Glu Ala Val Ile Lys Val Ile Ser Ser Ala Cys Lys Thr Tyr Cys 
1               5                   10                  15      


Gly Lys Ile Ser Pro Ser Lys Lys Glu Ile Gly Ala Met Leu Ser Leu 
            20                  25                  30          


Leu Gln Lys Glu Gly Leu Leu Met Ser Pro Ser Asp Leu Tyr Ser Pro 
        35                  40                  45              


Gly Ser Trp Asp Pro Ile Thr Ala Ala Leu Ser Gln Arg Ala Met Val 
    50                  55                  60                  


Leu Gly Lys Ser Gly Glu Leu Lys Thr Trp Gly Leu Val Leu Gly Ala 
65                  70                  75                  80  


Leu Lys Ala Ala Arg Glu Glu Gln Val Thr Ser Glu Gln Ala Lys Phe 
                85                  90                  95      


Trp Leu Gly Leu Gly Gly Gly Arg Val Ser Pro Pro Gly Pro Glu Cys 
            100                 105                 110         


Ile Glu Lys Pro Ala Thr Glu Arg Arg Ile Asp Lys Gly Glu Glu Val 
        115                 120                 125             


Gly Glu Thr Thr Val Gln Arg Asp Ala Lys Met Ala Pro Glu Glu Ala 
    130                 135                 140                 


Ala Thr Pro Lys Thr Val Gly Thr Ser Cys Tyr His Cys Gly Thr Ala 
145                 150                 155                 160 


Val Gly Cys Asn Cys Ala Thr Ala Thr Ala Ser Ala Pro Pro Pro Pro 
                165                 170                 175     


Tyr Val Gly Ser Gly Leu Tyr Pro Ser Leu Ala Gly Val Gly Glu Gln 
            180                 185                 190         


Gln Gly Gln Gly Asp Asn Thr Ser Arg Gly Ala Glu Gln Pro Arg Glu 
        195                 200                 205             


Glu Pro Gly His Ala Gly Gln Ala Pro Gly Pro Ala Leu Thr Asp Trp 
    210                 215                 220                 


Ala Arg Val Arg Glu Glu Leu Ala Ser Thr Gly Pro Pro Val Val Ala 
225                 230                 235                 240 


Met Pro Val Val Ile Lys Thr Glu Gly Pro Ala Trp Thr Pro Leu Glu 
                245                 250                 255     


Pro Lys Leu Ile Thr Arg Leu Ala Asp Thr Val Arg Thr Lys Gly Leu 
            260                 265                 270         


Arg Ser Pro Ile Thr Met Ala Glu Val Glu Ala Leu Met Ser Ser Pro 
        275                 280                 285             


Leu Leu Pro His Asp Val Thr Asn Leu Met Arg Val Ile Leu Gly Pro 
    290                 295                 300                 


Ala Pro Tyr Ala Leu Trp Met Asp Ala Trp Gly Val Gln Leu Gln Thr 
305                 310                 315                 320 


Val Ile Ala Ala Ala Thr Arg Asp Pro Arg His Pro Ala Asn Gly Gln 
                325                 330                 335     


Gly Arg Gly Glu Arg Thr Asn Leu Asp Arg Leu Lys Gly Leu Ala Asp 
            340                 345                 350         


Gly Met Val Gly Asn Pro Gln Gly Gln Ala Ala Leu Leu Arg Pro Gly 
        355                 360                 365             


Glu Leu Val Ala Ile Thr Ala Ser Ala Leu Gln Ala Phe Arg Glu Val 
    370                 375                 380                 


Ala Arg Leu Ala Glu Pro Ala Gly Pro Trp Ala Asp Ile Thr Gln Gly 
385                 390                 395                 400 


Pro Ser Glu Ser Phe Val Asp Phe Ala Asn Arg Leu Ile Lys Ala Val 
                405                 410                 415     


Glu Gly Ser Asp Leu Pro Pro Ser Ala Arg Ala Pro Val Ile Ile Asp 
            420                 425                 430         


Cys Phe Arg Gln Lys Ser Gln Pro Asp Ile Gln Gln Leu Ile Arg Ala 
        435                 440                 445             


Ala Pro Ser Thr Leu Thr Thr Pro Gly Glu Ile Ile Lys Tyr Val Leu 
    450                 455                 460                 


Asp Arg Gln Lys Ile Ala Pro Leu Thr Asp Gln Gly Ile Ala Ala Ala 
465                 470                 475                 480 


Met Ser Ser Ala Ile Gln Pro Leu Val Met Ala Val Val Asn Arg Glu 
                485                 490                 495     


Arg Asp Gly Gln Thr Gly Ser Gly Gly Arg Ala Arg Gly Leu Cys Tyr 
            500                 505                 510         


Thr Cys Gly Ser Pro Gly His Tyr Gln Ala Gln Cys Pro Lys Lys Arg 
        515                 520                 525             


Lys Ser Gly Asn Ser Arg Glu Arg Cys Gln Leu Cys Asp Gly Met Gly 
    530                 535                 540                 


His Asn Ala Lys Gln Cys Arg Lys Arg Asp Gly Asn Gln Gly Gln Arg 
545                 550                 555                 560 


Pro Gly Arg Gly Leu Ser Ser Gly Pro Trp Pro Gly Pro Glu Gln Pro 
                565                 570                 575     


Ala Val Ser Leu Ala Met Thr Met Glu His Lys Asp Arg Pro Leu Val 
            580                 585                 590         


Arg Val Ile Leu Thr Asn Thr Gly Ser His Pro Val Lys Gln Arg Ser 
        595                 600                 605             


Val Tyr Ile Thr Ala Leu Leu Asp Ser Gly Ala Asp Ile Thr Ile Ile 
    610                 615                 620                 


Ser Glu Glu Asp Trp Pro Thr Asp Trp Pro Val Val Asp Thr Ala Asn 
625                 630                 635                 640 


Pro Gln Ile His Gly Ile Gly Gly Gly Ile Pro Met Arg Lys Ser Arg 
                645                 650                 655     


Asp Met Ile Glu Val Gly Val Ile Asn Arg Asp Gly Ser Leu Glu Arg 
            660                 665                 670         


Pro Leu Leu Leu Phe Pro Ala Val Ala Met Val Arg Gly Ser Ile Leu 
        675                 680                 685             


Gly Arg Asp Cys Leu Gln Gly Leu Gly Leu Arg Leu Thr Asn Leu 
    690                 695                 700             


<210>  16
<211>  895
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Thr Val Ala Leu His Leu Ala Ile Pro Leu Lys Trp Lys Ser Asp Arg 
1               5                   10                  15      


Thr Pro Val Trp Ile Asp Gln Trp Pro Leu Pro Glu Gly Lys Leu Val 
            20                  25                  30          


Ala Leu Thr Gln Leu Val Glu Lys Glu Leu Gln Leu Gly His Ile Glu 
        35                  40                  45              


Pro Ser Leu Ser Cys Trp Asn Thr Pro Val Phe Val Ile Arg Lys Ala 
    50                  55                  60                  


Ser Gly Ser Tyr Arg Leu Leu His Asp Leu Arg Ala Val Asn Ala Lys 
65                  70                  75                  80  


Leu Val Pro Phe Gly Ala Val Gln Gln Gly Ala Pro Val Leu Ser Ala 
                85                  90                  95      


Leu Pro Arg Gly Trp Pro Leu Met Val Leu Asp Leu Lys Asp Cys Phe 
            100                 105                 110         


Phe Ser Ile Pro Leu Ala Glu Gln Asp Arg Glu Ala Phe Ala Phe Thr 
        115                 120                 125             


Leu Pro Ser Val Asn Asn Gln Ala Pro Ala Arg Arg Phe Gln Trp Lys 
    130                 135                 140                 


Val Leu Pro Gln Gly Met Thr Cys Ser Pro Thr Ile Cys Gln Leu Val 
145                 150                 155                 160 


Val Gly Gln Val Leu Glu Pro Leu Arg Leu Lys His Pro Ala Leu Arg 
                165                 170                 175     


Met Leu His Tyr Met Asp Asp Leu Leu Leu Ala Ala Ser Ser His Asp 
            180                 185                 190         


Gly Leu Glu Ala Ala Gly Lys Glu Val Ile Gly Thr Leu Glu Arg Ala 
        195                 200                 205             


Gly Phe Thr Ile Ser Pro Asp Lys Ile Gln Arg Glu Pro Gly Val Gln 
    210                 215                 220                 


Tyr Leu Gly Tyr Lys Leu Gly Ser Thr Tyr Val Ala Pro Val Gly Leu 
225                 230                 235                 240 


Val Ala Glu Pro Arg Ile Ala Thr Leu Trp Asp Val Gln Lys Leu Val 
                245                 250                 255     


Gly Ser Leu Gln Trp Leu Arg Pro Ala Leu Gly Ile Pro Pro Arg Leu 
            260                 265                 270         


Met Gly Pro Phe Tyr Glu Gln Leu Arg Gly Ser Asp Pro Asn Glu Ala 
        275                 280                 285             


Arg Glu Trp Asn Leu Asp Met Lys Met Ala Trp Arg Glu Ile Val Gln 
    290                 295                 300                 


Leu Ser Thr Thr Ala Ala Leu Glu Arg Trp Asp Pro Ala Gln Pro Leu 
305                 310                 315                 320 


Glu Gly Ala Val Ala Arg Cys Glu Gln Gly Ala Ile Gly Val Leu Gly 
                325                 330                 335     


Gln Gly Leu Ser Thr His Pro Arg Pro Cys Leu Trp Leu Phe Ser Thr 
            340                 345                 350         


Gln Pro Thr Lys Ala Phe Thr Ala Trp Leu Glu Val Leu Thr Leu Leu 
        355                 360                 365             


Ile Thr Lys Leu Arg Ala Ser Ala Val Arg Thr Phe Gly Lys Glu Val 
    370                 375                 380                 


Asp Ile Leu Leu Leu Pro Ala Cys Phe Arg Glu Asp Leu Pro Leu Pro 
385                 390                 395                 400 


Glu Gly Ile Leu Leu Ala Leu Arg Gly Phe Ala Gly Lys Ile Arg Ser 
                405                 410                 415     


Ser Asp Thr Pro Ser Ile Phe Asp Ile Ala Arg Pro Leu His Val Ser 
            420                 425                 430         


Leu Lys Val Arg Val Thr Asp His Pro Val Pro Gly Pro Thr Val Phe 
        435                 440                 445             


Thr Asp Ala Ser Ser Ser Thr His Lys Gly Val Val Val Trp Arg Glu 
    450                 455                 460                 


Gly Pro Arg Trp Glu Ile Lys Glu Ile Val Asp Leu Gly Ala Ser Val 
465                 470                 475                 480 


Gln Gln Leu Glu Ala Arg Ala Val Ala Met Ala Leu Leu Leu Trp Pro 
                485                 490                 495     


Thr Thr Pro Thr Asn Val Val Thr Asp Ser Ala Phe Val Ala Lys Met 
            500                 505                 510         


Leu Leu Lys Met Gly Gln Glu Gly Val Pro Ser Thr Ala Ala Ala Phe 
        515                 520                 525             


Ile Leu Glu Asp Ala Leu Ser Gln Arg Ser Ala Met Ala Ala Val Leu 
    530                 535                 540                 


His Val Arg Ser His Ser Glu Val Pro Gly Phe Phe Thr Glu Gly Asn 
545                 550                 555                 560 


Asp Val Ala Asp Ser Gln Ala Thr Phe Gln Ala Tyr Pro Leu Arg Glu 
                565                 570                 575     


Ala Lys Asp Leu His Thr Ala Leu His Ile Gly Pro Arg Ala Leu Ser 
            580                 585                 590         


Lys Ala Cys Asn Ile Ser Met Gln Gln Ala Arg Glu Val Val Gln Thr 
        595                 600                 605             


Cys Pro His Cys Asn Ser Ala Pro Ala Leu Glu Ala Gly Val Asn Pro 
    610                 615                 620                 


Arg Gly Leu Gly Pro Leu Gln Ile Trp Gln Thr Asp Phe Thr Leu Glu 
625                 630                 635                 640 


Pro Arg Met Ala Pro Arg Ser Trp Leu Ala Val Thr Val Asp Thr Ala 
                645                 650                 655     


Ser Ser Ala Ile Val Val Thr Gln His Gly Arg Val Thr Ser Val Ala 
            660                 665                 670         


Ala Gln His His Trp Ala Thr Ala Ile Ala Val Leu Gly Arg Pro Lys 
        675                 680                 685             


Ala Ile Lys Thr Asp Asn Gly Ser Cys Phe Thr Ser Arg Ser Thr Arg 
    690                 695                 700                 


Glu Trp Leu Ala Arg Trp Gly Ile Ala His Thr Thr Gly Ile Pro Gly 
705                 710                 715                 720 


Asn Ser Gln Gly Gln Ala Met Val Glu Arg Ala Asn Arg Leu Leu Lys 
                725                 730                 735     


Asp Lys Ile Arg Val Leu Ala Glu Gly Asp Gly Phe Met Lys Arg Ile 
            740                 745                 750         


Pro Ala Ser Lys Gln Gly Glu Leu Leu Ala Lys Ala Met Tyr Ala Leu 
        755                 760                 765             


Asn His Phe Glu Arg Gly Glu Asn Thr Lys Thr Pro Val Gln Lys His 
    770                 775                 780                 


Trp Arg Pro Thr Val Leu Thr Glu Gly Pro Pro Val Lys Ile Arg Ile 
785                 790                 795                 800 


Glu Thr Gly Glu Trp Glu Lys Gly Trp Asn Val Leu Val Trp Gly Arg 
                805                 810                 815     


Gly Tyr Ala Ala Val Lys Asn Arg Asp Thr Asp Lys Val Ile Trp Val 
            820                 825                 830         


Pro Ser Arg Lys Val Lys Pro Asp Val Thr Gln Lys Asp Glu Val Thr 
        835                 840                 845             


Lys Lys Asp Glu Ala Ser Pro Leu Phe Ala Gly Ile Ser Asp Trp Ile 
    850                 855                 860                 


Pro Trp Glu Asp Glu Gln Glu Gly Leu Gln Gly Glu Thr Ala Ser Asn 
865                 870                 875                 880 


Lys Gln Glu Arg Pro Gly Glu Asp Thr Leu Ala Ala Asn Glu Ser 
                885                 890                 895 


