                         SEQUENCE LISTING

<110>  DSM IP Assets B.V.
 
<120>  ENZYME COMPOSITION FOR THE TREATMENT OF PANCREATIC INSUFFICIENCY

<130>  27291-WO-PCT

<160>  2     

<170>  PatentIn version 3.2

<210> 1
<211> 3235
<212> DNA
<213> Aspergillus niger

<400> 1
gttttcaatt tggactgaat tttggcggca tttcttgtat aaaattaaaa ggggcgttga     60

ctggattttg gtacttggga tttattctta gctttgactg tacatagttt gggcgtggtt    120

tgatagccga cgatcggccg acccacgaac cagatttgca tatgattaca ttccttcaat    180

tttggtccga gtcccaaccc gcctttcaac cccaacaact acaagcacgt tgtgtttgct    240

acattgactc actcgatatt gctgaaccat gcaggccgcc caactgagtt attacaccaa    300

gcatgcgaat cggaaagttc gacaaagcgg gtgaaatgtc cgagttggcg aaccaaagcg    360

caacggtcga ggctcctttc cccgcagagg cagccattct gcagcctttg aactgcgggg    420

gaaacggcat ttgatcaact cggcactgat gcagtgacca acaggatgtt agcaatgttg    480

gcctaatata ttcttactga tctgctgata cgtccctccc ttgcatcagc ctcggtttgc    540

gcatgagaac gggttcgaac gttcctgggc cacccggttg gcgtgatatt ctccgcccac    600

gctgtctgtc cccctgatgg gaaaccttcg gatcagcgat catcaggcca gttggctatg    660

agaatagggg ctttgctgtc ttgatgccta aaatgcaggt ctcatagcaa gatccacagc    720

cgaggaggca catggcgatg tcgaaaccca tgggagctga tttttcggtt ctcggatcgt    780

gctccaagac atagaaggat attgagcact tgaaacgaag gggtgaaaaa tggaactgta    840

tatagagtta ctcccagccc gatccgagag cctatgaccc atagcggtac agatcatggc    900

catcatgaag gccctccttt ggctctccct ttccctcgcc gtctgggcga ctccagttca    960

acgggatgca gctcctactg tcactattgc gcatccatcg gccaccgtca ttggaaaatc   1020

tggcaatgtc gagagcttca acaatattcc ctttgcgcag gcccccacag gctcgctgcg   1080

tctgaagccc ccacaaccct tggaaactgc cctcggcact gttcaggcca caggagcctc   1140

gcaatcgtgt ccgcagatgt acttcaccac ggatgagagc gaattcccga catcggtcat   1200

tggcctcctc gctgatctcc ctttggtaca gtcggctacc aatgctctcg aggattgcct   1260

gaacattgac attcggcgtc cggccgggac caccgcggac tcgaagctgc ctgtgctggt   1320

ctggatcttt ggcggaggct ttgaacttgg ttcaaaggcg atgtatgatg gtacaacgat   1380

ggtatcatcg tcgatagaca agaacatgcc tatcgtgttt gtagcaatga attatcgcgt   1440

gggaggtttc gggttcttgc ccggaaagga gatcctggag gacgggtccg cgaacctagg   1500

gctcctggac caacgccttg ccctgcagtg ggttgccgac aacatcgagg cctttggtgg   1560

agacccggac aaggtgacga tttggggaga atcagcagga gccatttccg tttttgatca   1620

gatgatcttg tacgacggaa acatcactta caaggataag cccttgttcc ggggggccat   1680

catggactcc ggtagtgttg ttcccgcaga ccccgtcgat ggggtcaagg gacagcaagt   1740

atatgatgcg gtagtggaat ctgcaggctg ttcctcttct aacgacaccc tagcttgtct   1800

gcgtgaacta gactacaccg acttcctcaa tgcggcaaac tccgtgccag gcattttaag   1860

ctaccattct gtggcgttat catatgtgcc tcgaccggac gggacggcgt tgtcggcatc   1920

accggacgtt ttgggcaaag cagggaaata tgctcgggtc ccgttcatcg tgggcgacca   1980

agaggatgag gggaccttat tcgccttgtt tcagtccaac attacgacga tcgacgaggt   2040

ggtcgactac ctggcctcat acttcttcta tgacgctagc cgagagcagc ttgaagaact   2100

agtggccctg tacccagaca ccaccacgta cgggtctccg ttcaggacag gcgcggccaa   2160

caactggtat ccgcaattta agcgattggc cgccattctc ggcgacttgg tcttcaccat   2220

tacccggcgg gcattcctct cgtatgcaga ggaaatctcc cctgatcttc cgaactggtc   2280

gtacctggcg acctatgact atggcacccc agttctgggg accttccacg gaagtgacct   2340

gctgcaggtg ttctatggga tcaagccaaa ctatgcagct agttctagcc acacgtacta   2400

tctgagcttt gtgtatacgc tggatccgaa ctccaaccgg ggggagtaca ttgagtggcc   2460

gcagtggaag gaatcgcggc agttgatgaa tttcggagcg aacgacgcca gtctccttac   2520

ggatgatttc cgcaacggga catatgagtt catcctgcag aataccgcgg cgttccacat   2580

ctgatgccat tggcggaggg gtccggacgg tcaggaactt agccttatga gatgaatgat   2640

ggacgtgtct ggcctcggaa aaggatatat ggggatcatg atagtactag ccatattaat   2700

gaagggcata taccacgcgt tggacctgcg ttatagcttc ccgttagtta tagtaccatc   2760

gttataccag ccaatcaagt caccacgcac gaccggggac ggcgaatccc cgggaattga   2820

aagaaattgc atcccaggcc agtgaggcca gcgattggcc acctctccaa ggcacagggc   2880

cattctgcag cgctggtgga ttcatcgcaa tttcccccgg cccggcccga caccgctata   2940

ggctggttct cccacaccat cggagattcg tcgcctaatg tctcgtccgt tcacaagctg   3000

aagagcttga agtggcgaga tgtctctgca ggaattcaag ctagatgcta agcgatattg   3060

catggcaata tgtgttgatg catgtgcttc ttccttcagc ttcccctcgt gcagatgagg   3120

tttggctata aattgaagtg gttggtcggg gttccgtgag gggctgaagt gcttcctccc   3180

ttttagacgc aactgagagc ctgagcttca tccccagcat cattacacct cagca        3235
       

<210> 2
<211> 562
<212> PRT
<213> Aspergillus niger

<400> 2

Met Ala Ile Met Lys Ala Leu Leu Trp Leu Ser Leu Ser Leu Ala Val 
1               5                   10                  15      


Trp Ala Thr Pro Val Gln Arg Asp Ala Ala Pro Thr Val Thr Ile Ala 
            20                  25                  30          


His Pro Ser Ala Thr Val Ile Gly Lys Ser Gly Asn Val Glu Ser Phe 
        35                  40                  45              


Asn Asn Ile Pro Phe Ala Gln Ala Pro Thr Gly Ser Leu Arg Leu Lys 
    50                  55                  60                  


Pro Pro Gln Pro Leu Glu Thr Ala Leu Gly Thr Val Gln Ala Thr Gly 
65                  70                  75                  80  


Ala Ser Gln Ser Cys Pro Gln Met Tyr Phe Thr Thr Asp Glu Ser Glu 
                85                  90                  95      


Phe Pro Thr Ser Val Ile Gly Leu Leu Ala Asp Leu Pro Leu Val Gln 
            100                 105                 110         


Ser Ala Thr Asn Ala Leu Glu Asp Cys Leu Asn Ile Asp Ile Arg Arg 
        115                 120                 125             


Pro Ala Gly Thr Thr Ala Asp Ser Lys Leu Pro Val Leu Val Trp Ile 
    130                 135                 140                 


Phe Gly Gly Gly Phe Glu Leu Gly Ser Lys Ala Met Tyr Asp Gly Thr 
145                 150                 155                 160 


Thr Met Val Ser Ser Ser Ile Asp Lys Asn Met Pro Ile Val Phe Val 
                165                 170                 175     


Ala Met Asn Tyr Arg Val Gly Gly Phe Gly Phe Leu Pro Gly Lys Glu 
            180                 185                 190         


Ile Leu Glu Asp Gly Ser Ala Asn Leu Gly Leu Leu Asp Gln Arg Leu 
        195                 200                 205             


Ala Leu Gln Trp Val Ala Asp Asn Ile Glu Ala Phe Gly Gly Asp Pro 
    210                 215                 220                 


Asp Lys Val Thr Ile Trp Gly Glu Ser Ala Gly Ala Ile Ser Val Phe 
225                 230                 235                 240 


Asp Gln Met Ile Leu Tyr Asp Gly Asn Ile Thr Tyr Lys Asp Lys Pro 
                245                 250                 255     


Leu Phe Arg Gly Ala Ile Met Asp Ser Gly Ser Val Val Pro Ala Asp 
            260                 265                 270         


Pro Val Asp Gly Val Lys Gly Gln Gln Val Tyr Asp Ala Val Val Glu 
        275                 280                 285             


Ser Ala Gly Cys Ser Ser Ser Asn Asp Thr Leu Ala Cys Leu Arg Glu 
    290                 295                 300                 


Leu Asp Tyr Thr Asp Phe Leu Asn Ala Ala Asn Ser Val Pro Gly Ile 
305                 310                 315                 320 


Leu Ser Tyr His Ser Val Ala Leu Ser Tyr Val Pro Arg Pro Asp Gly 
                325                 330                 335     


Thr Ala Leu Ser Ala Ser Pro Asp Val Leu Gly Lys Ala Gly Lys Tyr 
            340                 345                 350         


Ala Arg Val Pro Phe Ile Val Gly Asp Gln Glu Asp Glu Gly Thr Leu 
        355                 360                 365             


Phe Ala Leu Phe Gln Ser Asn Ile Thr Thr Ile Asp Glu Val Val Asp 
    370                 375                 380                 


Tyr Leu Ala Ser Tyr Phe Phe Tyr Asp Ala Ser Arg Glu Gln Leu Glu 
385                 390                 395                 400 


Glu Leu Val Ala Leu Tyr Pro Asp Thr Thr Thr Tyr Gly Ser Pro Phe 
                405                 410                 415     


Arg Thr Gly Ala Ala Asn Asn Trp Tyr Pro Gln Phe Lys Arg Leu Ala 
            420                 425                 430         


Ala Ile Leu Gly Asp Leu Val Phe Thr Ile Thr Arg Arg Ala Phe Leu 
        435                 440                 445             


Ser Tyr Ala Glu Glu Ile Ser Pro Asp Leu Pro Asn Trp Ser Tyr Leu 
    450                 455                 460                 


Ala Thr Tyr Asp Tyr Gly Thr Pro Val Leu Gly Thr Phe His Gly Ser 
465                 470                 475                 480 


Asp Leu Leu Gln Val Phe Tyr Gly Ile Lys Pro Asn Tyr Ala Ala Ser 
                485                 490                 495     


Ser Ser His Thr Tyr Tyr Leu Ser Phe Val Tyr Thr Leu Asp Pro Asn 
            500                 505                 510         


Ser Asn Arg Gly Glu Tyr Ile Glu Trp Pro Gln Trp Lys Glu Ser Arg 
        515                 520                 525             


Gln Leu Met Asn Phe Gly Ala Asn Asp Ala Ser Leu Leu Thr Asp Asp 
    530                 535                 540                 


Phe Arg Asn Gly Thr Tyr Glu Phe Ile Leu Gln Asn Thr Ala Ala Phe 
545                 550                 555                 560 


His Ile 
        
