                         SEQUENCE LISTING

<110>  THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
       Goldfarb, Mitchell
 
<120>  ISOLATED A-TYPE FHF N-TERMINAL DOMAIN PEPTIDES

<130>  1038-43 PCT

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid sequence

<400>  1

Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala Arg 
1               5                   10                  15      


Glu Ser Asn Ser 
            20  


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid sequence

<400>  2

Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala Arg 
1               5                   10                  15      


Glu Arg Glu Lys 
            20  


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid sequence

<400>  3

Ala Ala Leu Ala Ser Ser Leu Ile Arg Gln Lys Arg Glu Val Arg Glu 
1               5                   10                  15      


Pro Gly Gly Ser 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid sequence

<400>  4

Ala Ala Ala Ile Ala Ser Gly Leu Ile Arg Gln Lys Arg Gln Ala Arg 
1               5                   10                  15      


Glu Gln His Trp 
            20  


<210>  5
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid sequence: hFHF-1B

<400>  5

Met Glu Ser Lys Glu Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Phe 
1               5                   10                  15      


Ser Gln Gln Gly Tyr Phe Leu Gln Met His Pro Asp Gly Thr Ile Asp 
            20                  25                  30          


Gly Thr Lys Asp Glu Asn Ser Asp Tyr Thr Leu Phe Asn Leu Ile Pro 
        35                  40                  45              


Val Gly Leu Arg Val Val Ala Ile Gln Gly Val Lys Ala Ser Leu Tyr 
    50                  55                  60                  


Val Ala Met Asn Gly Glu Gly Tyr Leu Tyr Ser Ser Asp Val Phe Thr 
65                  70                  75                  80  


Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile 
                85                  90                  95      


Tyr Ser Ser Thr Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe 
            100                 105                 110         


Leu Gly Leu Asn Lys Glu Gly Gln Ile Met Lys Gly Asn Arg Val Lys 
        115                 120                 125             


Lys Thr Lys Pro Ser Ser His Phe Val Pro Lys Pro Ile Glu Val Cys 
    130                 135                 140                 


Met Tyr Arg Glu Pro Ser Leu His Glu Ile Gly Glu Lys Gln Gly Arg 
145                 150                 155                 160 


Ser Arg Lys Ser Ser Gly Thr Pro Thr Met Asn Gly Gly Lys Val Val 
                165                 170                 175     


Asn Gln Asp Ser Thr 
            180     


<210>  6
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid sequence: hFHF-2B

<400>  6

Met Ala Leu Leu Arg Lys Ser Tyr Ser Glu Pro Gln Leu Lys Gly Ile 
1               5                   10                  15      


Val Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His Leu Gln Leu Gln Ala 
            20                  25                  30          


Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp Ser Thr Tyr Thr Leu 
        35                  40                  45              


Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val Ala Ile Gln Gly Val 
    50                  55                  60                  


Gln Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu Gly Tyr Leu Tyr Thr 
65                  70                  75                  80  


Ser Glu Leu Phe Thr Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu 
                85                  90                  95      


Asn Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr Arg Gln Gln Gln Ser 
            100                 105                 110         


Gly Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu Gly Glu Ile Met Lys 
        115                 120                 125             


Gly Asn His Val Lys Lys Asn Lys Pro Ala Ala His Phe Leu Pro Lys 
    130                 135                 140                 


Pro Leu Lys Val Ala Met Tyr Lys Glu Pro Ser Leu His Asp Leu Thr 
145                 150                 155                 160 


Glu Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr Lys Ser Arg Ser Val 
                165                 170                 175     


Ser Gly Val Leu Asn Gly Gly Lys Ser Met Ser His Asn Glu Ser Thr 
            180                 185                 190         


<210>  7
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid sequence: hFHF4b

<400>  7

Met Val Lys Pro Val Pro Leu Phe Arg Arg Thr Asp Phe Lys Leu Leu 
1               5                   10                  15      


Leu Cys Asn His Lys Asp Leu Phe Phe Leu Arg Val Ser Lys Leu Leu 
            20                  25                  30          


Asp Cys Phe Ser Pro Lys Ser Met Trp Phe Leu Trp Asn Ile Phe Ser 
        35                  40                  45              


Lys Gly Thr His Met Leu Gln Cys Leu Cys Gly Lys Ser Leu Lys Lys 
    50                  55                  60                  


Asn Lys Asn Pro Thr Asp Pro Gln Leu Lys Gly Ile Val Thr Arg Leu 
65                  70                  75                  80  


Tyr Cys Arg Gln Gly Tyr Tyr Leu Gln Met His Pro Asp Gly Ala Leu 
                85                  90                  95      


Asp Gly Thr Lys Asp Asp Ser Thr Asn Ser Thr Leu Phe Asn Leu Ile 
            100                 105                 110         


Pro Val Gly Leu Arg Val Val Ala Ile Gln Gly Val Lys Thr Gly Leu 
        115                 120                 125             


Tyr Ile Ala Met Asn Gly Glu Gly Tyr Leu Tyr Pro Ser Glu Leu Phe 
    130                 135                 140                 


Thr Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val 
145                 150                 155                 160 


Ile Tyr Ser Ser Met Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp 
                165                 170                 175     


Phe Leu Gly Leu Asn Lys Glu Gly Gln Ala Met Lys Gly Asn Arg Val 
            180                 185                 190         


Lys Lys Thr Lys Pro Ala Ala His Phe Leu Pro Lys Pro Leu Glu Val 
        195                 200                 205             


Ala Met Tyr Arg Glu Pro Ser Leu His Asp Val Gly Glu Thr Val Pro 
    210                 215                 220                 


Lys Pro Gly Val Thr Pro Ser Lys Ser Thr Ser Ala Ser Ala Ile Met 
225                 230                 235                 240 


Asn Gly Gly Lys Pro Val Asn Lys Ser Lys Thr Thr 
                245                 250         


<210>  8
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid sequence: mFHF-1A

<400>  8

Met Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Ser Asn Ser Asp Arg Val Ser Ala Ser Lys Arg Arg Ser Ser 
            20                  25                  30          


Pro Ser Lys Asp Gly Arg Ser Leu Cys Asp Arg His Val Leu Gly Val 
        35                  40                  45              


Phe Ser Lys Val Arg Phe Cys Ser Gly Arg Lys Arg Pro Val Arg Arg 
    50                  55                  60                  


Arg Pro Glu Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Phe Ser Gln 
65                  70                  75                  80  


Gln Gly Tyr Phe Leu Gln Met His Pro Asp Gly Thr Ile Asp Gly Thr 
                85                  90                  95      


Lys Asp Glu Asn Ser Asp Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly 
            100                 105                 110         


Leu Arg Val Val Ala Ile Gln Gly Val Lys Ala Ser Leu Tyr Val Ala 
        115                 120                 125             


Met Asn Gly Glu Gly Tyr Leu Tyr Ser Ser Asp Val Phe Thr Pro Glu 
    130                 135                 140                 


Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile Tyr Ser 
145                 150                 155                 160 


Ser Thr Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe Leu Gly 
                165                 170                 175     


Leu Asn Lys Glu Gly Gln Ile Met Lys Gly Asn Arg Val Lys Lys Thr 
            180                 185                 190         


Lys Pro Ser Ser His Phe Val Pro Lys Pro Ile Glu Val Cys Met Tyr 
        195                 200                 205             


Arg Glu Pro Ser Leu His Glu Ile Gly Glu Lys Gln Gly Arg Ser Arg 
    210                 215                 220                 


Lys Ser Ser Gly Thr Pro Thr Met Asn Gly Gly Lys Val Val Asn Gln 
225                 230                 235                 240 


Asp Ser Thr 
            


<210>  9
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid sequence: hFHF-2A

<400>  9

Met Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Arg Glu Lys Ser Asn Ala Cys Lys Cys Val Ser Ser Pro Ser 
            20                  25                  30          


Lys Gly Lys Thr Ser Cys Asp Lys Asn Lys Leu Asn Val Phe Ser Arg 
        35                  40                  45              


Val Lys Leu Phe Gly Ser Lys Lys Arg Arg Arg Arg Arg Pro Glu Pro 
    50                  55                  60                  


Gln Leu Lys Gly Ile Val Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His 
65                  70                  75                  80  


Leu Gln Leu Gln Ala Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp 
                85                  90                  95      


Ser Thr Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val 
            100                 105                 110         


Ala Ile Gln Gly Val Gln Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu 
        115                 120                 125             


Gly Tyr Leu Tyr Thr Ser Glu Leu Phe Thr Pro Glu Cys Lys Phe Lys 
    130                 135                 140                 


Glu Ser Val Phe Glu Asn Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr 
145                 150                 155                 160 


Arg Gln Gln Gln Ser Gly Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu 
                165                 170                 175     


Gly Glu Ile Met Lys Gly Asn His Val Lys Lys Asn Lys Pro Ala Ala 
            180                 185                 190         


His Phe Leu Pro Lys Pro Leu Lys Val Ala Met Tyr Lys Glu Pro Ser 
        195                 200                 205             


Leu His Asp Leu Thr Glu Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr 
    210                 215                 220                 


Lys Ser Arg Ser Val Ser Gly Val Leu Asn Gly Gly Lys Ser Met Ser 
225                 230                 235                 240 


His Asn Glu Ser Thr 
                245 


<210>  10
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid sequence:hFHF-4A

<400>  10

Met Ala Ala Ala Ile Ala Ser Gly Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Gln His Trp Asp Arg Pro Ser Ala Ser Arg Arg Arg Ser Ser 
            20                  25                  30          


Pro Ser Lys Asn Arg Gly Leu Cys Asn Gly Asn Leu Val Asp Ile Phe 
        35                  40                  45              


Ser Lys Val Arg Ile Phe Gly Leu Lys Lys Arg Arg Leu Arg Arg Gln 
    50                  55                  60                  


Asp Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Tyr Cys Arg Gln Gly 
65                  70                  75                  80  


Tyr Tyr Leu Gln Met His Pro Asp Gly Ala Leu Asp Gly Thr Lys Asp 
                85                  90                  95      


Asp Ser Thr Asn Ser Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg 
            100                 105                 110         


Val Val Ala Ile Gln Gly Val Lys Thr Gly Leu Tyr Ile Ala Met Asn 
        115                 120                 125             


Gly Glu Gly Tyr Leu Tyr Pro Ser Glu Leu Phe Thr Pro Glu Cys Lys 
    130                 135                 140                 


Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile Tyr Ser Ser Met 
145                 150                 155                 160 


Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe Leu Gly Leu Asn 
                165                 170                 175     


Lys Glu Gly Gln Ala Met Lys Gly Asn Arg Val Lys Lys Thr Lys Pro 
            180                 185                 190         


Ala Ala His Phe Leu Pro Lys Pro Leu Glu Val Ala Met Tyr Arg Glu 
        195                 200                 205             


Pro Ser Leu His Asp Val Gly Glu Thr Val Pro Lys Pro Gly Val Thr 
    210                 215                 220                 


Pro Ser Lys Ser Thr Ser Ala Ser Ala Ile Met Asn Gly Gly Lys Pro 
225                 230                 235                 240 


Val Asn Lys Ser Lys Thr Thr 
                245         


<210>  11
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid sequence: hFHF-3A

<400>  11

Met Ala Ala Leu Ala Ser Ser Leu Ile Arg Gln Lys Arg Glu Val Arg 
1               5                   10                  15      


Glu Pro Gly Gly Ser Arg Pro Val Ser Ala Gln Arg Arg Val Cys Pro 
            20                  25                  30          


Arg Gly Thr Lys Ser Leu Cys Gln Lys Gln Leu Leu Ile Leu Leu Ser 
        35                  40                  45              


Lys Val Arg Leu Cys Gly Gly Arg Pro Ala Arg Pro Asp Arg Gly Pro 
    50                  55                  60                  


Glu Pro Gln Leu Lys Gly Ile Val Thr Lys Leu Phe Cys Arg Gln Gly 
65                  70                  75                  80  


Phe Tyr Leu Gln Ala Asn Pro Asp Gly Ser Ile Gln Gly Thr Pro Glu 
                85                  90                  95      


Asp Thr Ser Ser Phe Thr His Phe Asn Leu Ile Pro Val Gly Leu Arg 
            100                 105                 110         


Val Val Thr Ile Gln Ser Ala Lys Leu Gly His Tyr Met Ala Met Asn 
        115                 120                 125             


Ala Glu Gly Leu Leu Tyr Ser Ser Pro His Phe Thr Ala Glu Cys Arg 
    130                 135                 140                 


Phe Lys Glu Cys Val Phe Glu Asn Tyr Tyr Val Leu Tyr Ala Ser Ala 
145                 150                 155                 160 


Leu Tyr Arg Gln Arg Arg Ser Gly Arg Ala Trp Tyr Leu Gly Leu Asp 
                165                 170                 175     


Lys Glu Gly Gln Val Met Lys Gly Asn Arg Val Lys Lys Thr Lys Ala 
            180                 185                 190         


Ala Ala His Phe Leu Pro Lys Leu Leu Glu Val Ala Met Tyr Gln Glu 
        195                 200                 205             


Pro Ser Leu His Ser Val Pro Glu Ala Ser Pro Ser Ser Pro Pro Ala 
    210                 215                 220                 


Pro 
225 


