                         SEQUENCE LISTING

<110>  Cytochroma Inc.
       Petkovich, et al.
 
<120>  Methods and Compositions for Measuring the Amount of Vitamin 
       Derivatives

<130>  31138/44172A

<150>  US-61/175,919
<151>  2009-05-06

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ala Met Ala Ala Ser Thr Ser Leu Pro Asp Pro Gly Asp Phe 
1               5                   10                  15      


Asp Arg Asn Val Pro Arg Ile Cys Gly Val Cys Gly Asp Arg Ala Thr 
            20                  25                  30          


Gly Phe His Phe Asn Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe 
        35                  40                  45              


Arg Arg Ser Met Lys Arg Lys Ala Leu Phe Thr Cys Pro Phe Asn Gly 
    50                  55                  60                  


Asp Cys Arg Ile Thr Lys Asp Asn Arg Arg His Cys Gln Ala Cys Arg 
65                  70                  75                  80  


Leu Lys Arg Cys Val Asp Ile Gly Met Met Lys Glu Phe Ile Leu Thr 
                85                  90                  95      


Asp Glu Glu Val Gln Arg Lys Arg Glu Met Ile Leu Lys Arg Lys Glu 
            100                 105                 110         


Glu Glu Ala Leu Lys Asp Ser Leu Arg Pro Lys Leu Ser Glu Glu Gln 
        115                 120                 125             


Gln Arg Ile Ile Ala Ile Leu Leu Asp Ala His His Lys Thr Tyr Asp 
    130                 135                 140                 


Pro Thr Tyr Ser Asp Phe Cys Gln Phe Arg Pro Pro Val Arg Val Asn 
145                 150                 155                 160 


Asp Gly Gly Gly Ser His Pro Ser Arg Pro Asn Ser Arg His Thr Pro 
                165                 170                 175     


Ser Phe Ser Gly Asp Ser Ser Ser Ser Cys Ser Asp His Cys Ile Thr 
            180                 185                 190         


Ser Ser Asp Met Met Asp Ser Ser Ser Phe Ser Asn Leu Asp Leu Ser 
        195                 200                 205             


Glu Glu Asp Ser Asp Asp Pro Ser Val Thr Leu Glu Leu Ser Gln Leu 
    210                 215                 220                 


Ser Met Leu Pro His Leu Ala Asp Leu Val Ser Tyr Ser Ile Gln Lys 
225                 230                 235                 240 


Val Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Arg Asp Leu Thr Ser 
                245                 250                 255     


Glu Asp Gln Ile Val Leu Leu Lys Ser Ser Ala Ile Glu Val Ile Met 
            260                 265                 270         


Leu Arg Ser Asn Glu Ser Phe Thr Met Asp Asp Met Ser Trp Thr Cys 
        275                 280                 285             


Gly Asn Gln Asp Tyr Lys Tyr Arg Val Ser Asp Val Thr Lys Ala Gly 
    290                 295                 300                 


His Ser Leu Glu Leu Ile Glu Pro Leu Ile Lys Phe Gln Val Gly Leu 
305                 310                 315                 320 


Lys Lys Leu Asn Leu His Glu Glu Glu His Val Leu Leu Met Ala Ile 
                325                 330                 335     


Cys Ile Val Ser Pro Asp Arg Pro Gly Val Gln Asp Ala Ala Leu Ile 
            340                 345                 350         


Glu Ala Ile Gln Asp Arg Leu Ser Asn Thr Leu Gln Thr Tyr Ile Arg 
        355                 360                 365             


Cys Arg His Pro Pro Pro Gly Ser His Leu Leu Tyr Ala Lys Met Ile 
    370                 375                 380                 


Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn Glu Glu His Ser Lys Gln 
385                 390                 395                 400 


Tyr Arg Cys Leu Ser Phe Gln Pro Glu Cys Ser Met Lys Leu Thr Pro 
                405                 410                 415     


Leu Val Leu Glu Val Phe Gly Asn Glu Ile Ser 
            420                 425         


<210>  2
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  2

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  3
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  3

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser Asp Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  4
<211>  740
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Lys Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Asp Ser 
225                 230                 235                 240 


Leu Arg Pro Lys Leu Ser Glu Glu Gln Gln Arg Ile Ile Ala Ile Leu 
                245                 250                 255     


Leu Asp Ala His His Lys Thr Tyr Asp Pro Thr Tyr Ser Asp Phe Cys 
            260                 265                 270         


Gln Phe Arg Pro Pro Val Arg Val Asn Asp Gly Gly Gly Ser Val Thr 
        275                 280                 285             


Leu Glu Leu Ser Gln Leu Ser Met Leu Pro His Leu Ala Asp Leu Val 
    290                 295                 300                 


Ser Tyr Ser Ile Gln Lys Val Ile Gly Phe Ala Lys Met Ile Pro Gly 
305                 310                 315                 320 


Phe Arg Asp Leu Thr Ser Glu Asp Gln Ile Val Leu Leu Lys Ser Ser 
                325                 330                 335     


Ala Ile Glu Val Ile Met Leu Arg Ser Asn Glu Ser Phe Thr Met Asp 
            340                 345                 350         


Asp Met Ser Trp Thr Cys Gly Asn Gln Asp Tyr Lys Tyr Arg Val Ser 
        355                 360                 365             


Asp Val Thr Lys Ala Gly His Ser Leu Glu Leu Ile Glu Pro Leu Ile 
    370                 375                 380                 


Lys Phe Gln Val Gly Leu Lys Lys Leu Asn Leu His Glu Glu Glu His 
385                 390                 395                 400 


Val Leu Leu Met Ala Ile Cys Ile Val Ser Pro Asp Arg Pro Gly Val 
                405                 410                 415     


Gln Asp Ala Ala Leu Ile Glu Ala Ile Gln Asp Arg Leu Ser Asn Thr 
            420                 425                 430         


Leu Gln Thr Tyr Ile Arg Cys Arg His Pro Pro Pro Gly Ser His Leu 
        435                 440                 445             


Leu Tyr Ala Lys Met Ile Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn 
    450                 455                 460                 


Glu Glu His Ser Lys Gln Tyr Arg Cys Leu Ser Phe Gln Pro Glu Cys 
465                 470                 475                 480 


Ser Met Lys Leu Thr Pro Leu Val Leu Glu Val Phe Gly Asn Glu Ile 
                485                 490                 495     


Ser Gly Ser Gly Thr Gly Val Ser Lys Gly Glu Glu Leu Phe Thr Gly 
            500                 505                 510         


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys 
        515                 520                 525             


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
    530                 535                 540                 


Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
545                 550                 555                 560 


Thr Leu Val Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ala Arg Tyr 
                565                 570                 575     


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
            580                 585                 590         


Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
        595                 600                 605             


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
    610                 615                 620                 


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
625                 630                 635                 640 


His Lys Leu Glu Tyr Asn Tyr Ile Ser Asp Asn Val Tyr Ile Thr Ala 
                645                 650                 655     


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn 
            660                 665                 670         


Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
        675                 680                 685             


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
    690                 695                 700                 


Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
705                 710                 715                 720 


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
                725                 730                 735     


Glu Leu Tyr Lys 
            740 


<210>  5
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Ile Cys Arg Val Cys Gly Asp Lys Ala Thr Gly Tyr His Phe Asn 
1               5                   10                  15      


Val Met Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ala Met Lys 
            20                  25                  30          


Arg Asn Ala Arg Leu Arg Cys Pro Phe Arg Lys Gly Ala Cys Glu Ile 
        35                  40                  45              


Thr Arg Lys Thr Arg Arg Gln Cys Gln Ala Cys Arg Leu Arg Lys Cys 
    50                  55                  60                  


Leu Glu Ser Gly Met 
65                  


<210>  6
<211>  68
<212>  PRT
<213>  Gallus gallus

<400>  6

Lys Val Cys Ala Val Cys Gly Asp Arg Ala Thr Gly Tyr His Phe His 
1               5                   10                  15      


Val Met Ser Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Ile Leu 
            20                  25                  30          


Lys Gly Val His Phe Thr Cys Pro Phe Thr Arg Ser Cys Pro Ile Thr 
        35                  40                  45              


Lys Ala Lys Arg Arg Gln Cys Gln Ala Cys Arg Leu Gln Lys Cys Leu 
    50                  55                  60                  


Asp Val Gly Met 
65              


<210>  7
<211>  68
<212>  PRT
<213>  Fugu rubripes

<400>  7

Arg Ala Cys Gly Val Cys Gly Asp Gln Ala Lys Gly Tyr His Phe Asn 
1               5                   10                  15      


Ala Trp Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ala Ile Lys 
            20                  25                  30          


Arg Thr Pro Pro Leu Pro Cys Gln Phe Leu Asn Lys Cys Ser Ile Thr 
        35                  40                  45              


Lys Lys Asn Arg Arg Gln Cys Gln Asp Cys Arg Leu Arg Lys Cys Gln 
    50                  55                  60                  


Ala Ile Gly Met 
65              


<210>  8
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Ile Cys Gly Val Cys Gly Asp Arg Ala Thr Gly Phe His Phe Asn 
1               5                   10                  15      


Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Met Lys 
            20                  25                  30          


Arg Lys Ala Leu Phe Thr Cys Pro Phe Asn Gly Asp Cys Arg Ile Thr 
        35                  40                  45              


Lys Asp Asn Arg Arg His Cys Gln Ala Cys Arg Leu Lys Arg Cys Val 
    50                  55                  60                  


Asp Ile Gly Met 
65              


<210>  9
<211>  68
<212>  PRT
<213>  Mus musculus

<400>  9

Arg Ile Cys Gly Val Cys Gly Asp Arg Ala Thr Gly Phe His Phe Asn 
1               5                   10                  15      


Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Met Lys 
            20                  25                  30          


Arg Lys Ala Leu Phe Thr Cys Pro Phe Asn Gly Asp Cys Arg Ile Thr 
        35                  40                  45              


Lys Asp Asn Arg Arg His Cys Gln Ala Cys Arg Leu Lys Arg Cys Val 
    50                  55                  60                  


Asp Ile Gly Met 
65              


<210>  10
<211>  68
<212>  PRT
<213>  Xenopus laevis

<400>  10

Arg Ile Cys Gly Val Cys Gly Asp Lys Ala Thr Gly Phe His Phe Asn 
1               5                   10                  15      


Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Met Lys 
            20                  25                  30          


Arg Lys Ala Met Phe Thr Cys Pro Phe Asn Gly Asp Cys Arg Ile Thr 
        35                  40                  45              


Lys Asp Asn Arg Arg His Cys Gln Ser Cys Arg Leu Lys Arg Cys Val 
    50                  55                  60                  


Asp Ile Gly Met 
65              


<210>  11
<211>  68
<212>  PRT
<213>  Danio rerio

<400>  11

Pro Ile Cys Gly Val Cys Gly Asp Lys Ala Thr Gly Phe His Phe Asn 
1               5                   10                  15      


Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Met Lys 
            20                  25                  30          


Arg Lys Ala Ser Phe Thr Cys Pro Phe Asn Gly Asn Cys Thr Ile Thr 
        35                  40                  45              


Lys Asp Asn Arg Arg His Cys Gln Ala Cys Arg Leu Lys Arg Cys Ile 
    50                  55                  60                  


Asp Ile Gly Met 
65              


<210>  12
<211>  68
<212>  PRT
<213>  Petromyzon marinus

<400>  12

Lys Val Cys Gly Val Cys Gly Asp Lys Ala Thr Gly Tyr His Phe Asn 
1               5                   10                  15      


Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Met Lys 
            20                  25                  30          


Arg Ser Ala Ser Phe Thr Cys Pro Phe Glu Gly Lys Cys Asn Ile Thr 
        35                  40                  45              


Lys Asp Asn Arg Arg His Cys Gln Ala Cys Arg Leu Lys Arg Cys Arg 
    50                  55                  60                  


Asp Ile Gly Met 
65              


<210>  13
<211>  56
<212>  PRT
<213>  Ciona intestinalis

<400>  13

Met His Phe Gly Ala Ile Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg 
1               5                   10                  15      


Arg Ser Val Lys Lys Asn Ala Ser Phe Ser Cys Ala Phe Glu Lys Lys 
            20                  25                  30          


Cys Glu Ile Asn Lys Asn Asn Arg Lys His Cys Gln Ala Cys Arg Phe 
        35                  40                  45              


Asn Ala Cys Leu Ala Ala Gly Met 
    50                  55      


<210>  14
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Asn Cys Val Val Cys Gly Asp Gln Ala Thr Gly Tyr His Phe Asn 
1               5                   10                  15      


Ala Leu Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Thr Val Ser 
            20                  25                  30          


Lys Ser Ile Gly Pro Thr Cys Pro Phe Ala Gly Ser Cys Glu Val Ser 
        35                  40                  45              


Lys Thr Gln Arg Arg His Cys Pro Ala Cys Arg Leu Gln Lys Cys Leu 
    50                  55                  60                  


Asp Ala Gly Met 
65              


<210>  15
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Gly Leu Thr Glu Glu Gln Arg Met Met Ile Arg Glu Leu Met Asp 
1               5                   10                  15      


Ala Gln Met Lys Thr Phe Asp Thr Thr Phe Ser His Phe Lys Asn Phe 
            20                  25                  30          


Arg Leu Pro Gly Val Leu Ser Ser Gly Cys Glu Leu Pro Glu Ser Leu 
        35                  40                  45              


Gln Ala Pro Ser Arg Glu Glu Ala Ala Lys Trp Ser Gln Val Arg Lys 
    50                  55                  60                  


Asp Leu Cys Ser Leu Lys Val Ser Leu Gln Leu Arg Gly Glu Asp Gly 
65                  70                  75                  80  


Ser Val Trp Asn Tyr Lys Pro Pro Ala Asp Ser Gly Gly Lys Glu Ile 
                85                  90                  95      


Phe Ser Leu Leu Pro His Met Ala Asp Met Ser Thr Tyr Met Phe Lys 
            100                 105                 110         


Gly Ile Ile Ser Phe Ala Lys Val Ile Ser Tyr Phe Arg Asp Leu Pro 
        115                 120                 125             


Ile Glu Asp Gln Ile Ser Leu Leu Lys Gly Ala Ala Phe Glu Leu Cys 
    130                 135                 140                 


Gln Leu Arg Phe Asn Thr Val Phe Asn Ala Glu Thr Gly Thr Trp Glu 
145                 150                 155                 160 


Cys Gly Arg Leu Ser Tyr Cys Leu Glu Asp Thr Ala Gly Gly Phe Gln 
                165                 170                 175     


Gln Leu Leu Leu Glu Pro Met Leu Lys Phe His Tyr Met Leu Lys Lys 
            180                 185                 190         


Leu Gln Leu His Glu Glu Glu Tyr Val Leu Met Gln Ala Ile Ser Leu 
        195                 200                 205             


Phe Ser Pro Asp Arg Pro Gly Val Leu Gln His Arg Val Ile Asp Gln 
    210                 215                 220                 


Leu Gln Glu Gln Phe Ala Ile Thr Leu Lys Ser Tyr Ile Glu Cys Asn 
225                 230                 235                 240 


Arg Pro Gln Pro Ala His Arg Phe Leu Phe Leu Lys Ile Met Ala Met 
                245                 250                 255     


Leu Thr Glu Leu Arg Ser Ile Asn Ala Gln His Thr Gln Arg Leu Leu 
            260                 265                 270         


Arg Ile Gln Asp Ile His Pro Phe Ala Thr Pro Leu Met Gln Glu Leu 
        275                 280                 285             


Phe Gly Ile Thr Gly Ser 
    290                 


<210>  16
<211>  267
<212>  PRT
<213>  Gallus gallus

<400>  16

Gly Gly Leu Thr Ala Glu Gln Gln Glu Leu Ile Ser Ile Leu Ile Ala 
1               5                   10                  15      


Ala His Lys Arg Thr Phe Asp Ser Ser Phe Ser Gln Phe Gln His Tyr 
            20                  25                  30          


Gln Pro Ala Val Arg Leu Cys Ile Pro Gly Pro Cys Ser Gln Ser Pro 
        35                  40                  45              


Pro Gly Pro Gly Val Pro Ser Ala Ser Leu Ser Pro Gln Leu Asp Cys 
    50                  55                  60                  


Leu Asp Glu Asp Val Leu Pro Asp Val Phe Ser Ile Leu Pro His Phe 
65                  70                  75                  80  


Ala Asp Leu Ser Thr Phe Met Ile Gln Gln Val Ile Lys Phe Ala Lys 
                85                  90                  95      


Glu Ile Pro Ala Phe Arg Gly Leu Pro Ile Asp Asp Gln Ile Ser Leu 
            100                 105                 110         


Leu Lys Gly Ala Thr Leu Gly Ile Cys Gln Ile Gln Phe Asn Thr Val 
        115                 120                 125             


Phe Asn Glu Glu Thr Asn Ala Trp Glu Cys Gly Gln His Cys Phe Thr 
    130                 135                 140                 


Ile Lys Asp Gly Ala Leu Ala Gly Phe Gln Gln Ile Tyr Leu Glu Pro 
145                 150                 155                 160 


Leu Leu Lys Phe His Ile Ser Leu Lys Lys Leu Arg Leu His Glu Ala 
                165                 170                 175     


Glu Tyr Val Leu Leu Val Ala Met Leu Leu Phe Ser Pro Asp His Ala 
            180                 185                 190         


Ser Val Thr Gln Arg Asp Phe Ile Asp Gln Leu Gln Glu Lys Val Ala 
        195                 200                 205             


Leu Thr Leu Lys Ser Tyr Ile Asp His Arg His Pro Met Pro Glu Gly 
    210                 215                 220                 


Arg Phe Leu Tyr Ala Lys Leu Leu Leu Leu Leu Thr Glu Leu Gln Thr 
225                 230                 235                 240 


Leu Lys Met Glu Asn Thr Arg Gln Ile Leu His Ile Gln Asp Leu Ser 
                245                 250                 255     


Ser Met Thr Pro Leu Leu Ser Glu Ile Ile Ser 
            260                 265         


<210>  17
<211>  295
<212>  PRT
<213>  Fugu rubripes

<400>  17

Ile His Leu Ser Ser Gln Gln Glu Glu Thr Ile Arg Glu Leu Leu Tyr 
1               5                   10                  15      


Gly His Arg Lys Thr Phe Asp Leu Glu Phe Tyr Arg Phe Ser Ser Phe 
            20                  25                  30          


Arg Val Arg Thr Ser Thr Thr Leu Phe Asp Leu Ser Lys Ser Leu Ser 
        35                  40                  45              


Glu Arg Leu Asn Ile Phe Ala Val Arg Gly Ser Ser Pro Ser Gly Pro 
    50                  55                  60                  


Ala Ser Ser Asp Val Ser Ser Leu Ser Thr Ser Ala Arg Leu Arg Gly 
65                  70                  75                  80  


Arg Pro Glu Thr Pro Gln Thr Gln Gly Gly Glu Asn Ala Arg Arg Gly 
                85                  90                  95      


Cys Val Phe Thr Ala Leu Pro His Val Thr Asp Leu Ala Thr Cys Met 
            100                 105                 110         


Ile His Asp Ile Ile Ala Phe Ser Lys Ser Leu Thr Asp Phe Lys Ser 
        115                 120                 125             


Leu Leu Ile Gly Asp Gln Ile Ala Leu Leu Lys Gly Ala Thr Phe Glu 
    130                 135                 140                 


Val Met Glu Ile Arg Phe Asn Met Val Phe Asn Thr Lys Thr Gly Leu 
145                 150                 155                 160 


Trp Glu Cys Gly His Ala Thr Tyr Cys Ile Glu Asp Ala Val Arg Ala 
                165                 170                 175     


Gly Phe Gln Pro Leu Phe Leu Glu Pro Leu Leu Lys Phe His His Thr 
            180                 185                 190         


Leu Arg Asn Leu Gly Leu Glu Glu Glu Glu Tyr Val Leu Met Gln Ala 
        195                 200                 205             


Leu Ser Leu Phe Ser Pro Asp Arg Pro Gly Val Gln Gln His Ser Val 
    210                 215                 220                 


Ile Asp Lys Ile His Glu Asn Leu Ala Leu Ala Leu Lys Thr Arg Ile 
225                 230                 235                 240 


Glu Leu Lys Arg Thr Gly Pro Glu Lys His Met Leu Tyr Pro Lys Val 
                245                 250                 255     


Leu Ser Cys Leu Thr Glu Met Arg Thr Met Asn Glu Glu Tyr Ser Lys 
            260                 265                 270         


Gln Val Leu Gln Ile Gln Asp Ile Gln Pro Asn Val Val Ile Pro Pro 
        275                 280                 285             


Leu Leu Met Glu Met Val Ser 
    290                 295 


<210>  18
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  18

Pro Lys Leu Ser Glu Glu Gln Gln Arg Ile Ile Ala Ile Leu Leu Asp 
1               5                   10                  15      


Ala His His Lys Thr Tyr Asp Pro Thr Tyr Ser Asp Phe Cys Gln Phe 
            20                  25                  30          


Arg Pro Pro Val Arg Val Asn Asp Gly Gly Gly Ser His Pro Ser Arg 
        35                  40                  45              


Pro Asn Ser Arg His Thr Pro Ser Phe Ser Gly Asp Ser Ser Ser Ser 
    50                  55                  60                  


Cys Ser Asp His Cys Ile Thr Ser Ser Asp Met Met Asp Ser Ser Ser 
65                  70                  75                  80  


Phe Ser Asn Leu Asp Leu Ser Glu Glu Asp Ser Asp Asp Pro Ser Val 
                85                  90                  95      


Thr Leu Glu Leu Ser Gln Leu Ser Met Leu Pro His Leu Ala Asp Leu 
            100                 105                 110         


Val Ser Tyr Ser Ile Gln Lys Val Ile Gly Phe Ala Lys Met Ile Pro 
        115                 120                 125             


Gly Phe Arg Asp Leu Thr Ser Glu Asp Gln Ile Val Leu Leu Lys Ser 
    130                 135                 140                 


Ser Ala Ile Glu Val Ile Met Leu Arg Ser Asn Glu Ser Phe Thr Met 
145                 150                 155                 160 


Asp Asp Met Ser Trp Thr Cys Gly Asn Gln Asp Tyr Lys Tyr Arg Val 
                165                 170                 175     


Ser Asp Val Thr Lys Ala Gly His Ser Leu Glu Leu Ile Glu Pro Leu 
            180                 185                 190         


Ile Lys Phe Gln Val Gly Leu Lys Lys Leu Asn Leu His Glu Glu Glu 
        195                 200                 205             


His Val Leu Leu Met Ala Ile Cys Ile Val Ser Pro Asp Arg Pro Gly 
    210                 215                 220                 


Val Gln Asp Ala Ala Leu Ile Glu Ala Ile Gln Asp Arg Leu Ser Asn 
225                 230                 235                 240 


Thr Leu Gln Thr Tyr Ile Arg Cys Arg His Pro Pro Pro Gly Ser His 
                245                 250                 255     


Leu Leu Tyr Ala Lys Met Ile Gln Lys Leu Ala Asp Leu Arg Ser Leu 
            260                 265                 270         


Asn Glu Glu His Ser Lys Gln Tyr Arg Cys Leu Ser Phe Gln Pro Glu 
        275                 280                 285             


Cys Ser Met Lys Leu Thr Pro Leu Val Leu Glu Val Phe Gly Asn Glu 
    290                 295                 300                 


Ile Ser 
305     


<210>  19
<211>  302
<212>  PRT
<213>  Mus musculus

<400>  19

Pro Lys Leu Ser Glu Glu Gln Gln His Ile Ile Ala Ile Leu Leu Asp 
1               5                   10                  15      


Ala His His Lys Thr Tyr Asp Pro Thr Tyr Ala Asp Phe Arg Asp Phe 
            20                  25                  30          


Arg Pro Pro Ile Arg Ala Asp Val Ala Thr Gly Ser Tyr Ser Pro Arg 
        35                  40                  45              


Pro Thr Leu Ser Phe Ser Gly Asp Ser Ser Ser Asn Ser Asp Leu Tyr 
    50                  55                  60                  


Thr Pro Ser Leu Asp Met Met Glu Pro Ala Ser Phe Ser Thr Met Asp 
65                  70                  75                  80  


Leu Asn Glu Glu Gly Ser Asp Asp Pro Ser Val Thr Leu Asp Leu Ser 
                85                  90                  95      


Pro Leu Ser Met Leu Pro His Leu Ala Asp Leu Val Ser Tyr Ser Ile 
            100                 105                 110         


Gln Lys Val Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Arg Asp Leu 
        115                 120                 125             


Thr Ser Asp Asp Gln Ile Val Leu Leu Lys Ser Ser Ala Ile Glu Val 
    130                 135                 140                 


Ile Met Leu Arg Ser Asn Gln Ser Phe Thr Met Asp Asp Met Ser Trp 
145                 150                 155                 160 


Asp Cys Gly Ser Gln Asp Tyr Lys Tyr Asp Ile Thr Asp Val Ser Arg 
                165                 170                 175     


Ala Gly His Thr Leu Glu Leu Ile Glu Pro Leu Ile Lys Phe Gln Val 
            180                 185                 190         


Gly Leu Lys Lys Leu Asn Leu His Glu Glu Glu His Val Leu Leu Met 
        195                 200                 205             


Ala Ile Cys Ile Val Ser Pro Asp Arg Pro Gly Val Gln Asp Ala Lys 
    210                 215                 220                 


Leu Val Glu Ala Ile Gln Asp Arg Leu Ser Asn Thr Leu Gln Thr Tyr 
225                 230                 235                 240 


Ile Arg Cys Arg His Pro Pro Pro Gly Ser His Gln Leu Tyr Ala Lys 
                245                 250                 255     


Met Ile Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn Glu Glu His Ser 
            260                 265                 270         


Lys Gln Tyr Arg Ser Leu Ser Phe Gln Pro Glu Asn Ser Ser Met Lys 
        275                 280                 285             


Leu Thr Pro Leu Val Leu Glu Val Phe Gly Asn Glu Ile Ser 
    290                 295                 300         


<210>  20
<211>  301
<212>  PRT
<213>  Xenopus laevis

<400>  20

Pro Lys Ile Ser Asp Glu Gln Gln Lys Met Ile Asp Ile Leu Leu Glu 
1               5                   10                  15      


Ala His Arg Lys Thr Phe Asp Thr Thr Tyr Ser Asp Phe Asn Lys Phe 
            20                  25                  30          


Arg Pro Pro Val Arg Glu Asn Val Asp Pro Phe Arg Arg Ile Thr Arg 
        35                  40                  45              


Ser Ser Ser Val His Thr Gln Gly Ser Pro Ser Glu Asp Ser Asp Val 
    50                  55                  60                  


Phe Thr Ser Ser Pro Asp Ser Ser Glu His Gly Phe Phe Ser Ala Ser 
65                  70                  75                  80  


Leu Phe Gly Gln Phe Glu Tyr Ser Ser Met Gly Gly Lys Ser Gly Glu 
                85                  90                  95      


Leu Ser Met Leu Pro His Ile Ala Asp Leu Val Ser Tyr Ser Ile Gln 
            100                 105                 110         


Lys Ile Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Arg Asp Leu Ile 
        115                 120                 125             


Ala Glu Asp Gln Ile Ala Leu Leu Lys Ser Ser Val Ile Glu Val Ile 
    130                 135                 140                 


Met Leu Arg Ser Asn Gln Ser Phe Ser Leu Asp Asp Met Ser Trp Thr 
145                 150                 155                 160 


Cys Gly Ser Glu Asp Phe Lys Tyr Lys Val Asp Asp Val Thr Gln Ala 
                165                 170                 175     


Gly His Asn Met Glu Leu Leu Glu Pro Leu Val Lys Phe Gln Val Gly 
            180                 185                 190         


Leu Lys Lys Leu Asp Leu His Glu Glu Glu His Val Leu Leu Met Ala 
        195                 200                 205             


Ile Cys Ile Leu Ser Pro Asp Arg Pro Gly Leu Gln Asp Lys Ala Leu 
    210                 215                 220                 


Val Glu Ser Ile Gln Asp Arg Leu Ser Ser Thr Leu Gln Thr Tyr Ile 
225                 230                 235                 240 


Leu Cys Lys His Pro Pro Pro Gly Ser Arg Leu Leu Tyr Ala Lys Met 
                245                 250                 255     


Ile Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn Glu Glu His Ser Lys 
            260                 265                 270         


Gln Tyr Arg Ser Ile Ser Phe Leu Pro Glu His Ser Ser Met Lys Leu 
        275                 280                 285             


Thr Pro Leu Met Leu Glu Val Phe Ser Asp Glu Ile Pro 
    290                 295                 300     


<210>  21
<211>  300
<212>  PRT
<213>  Danio rerio

<400>  21

Pro Arg Leu Ser Asp Glu Gln Met Gln Ile Ile Asn Ser Leu Val Glu 
1               5                   10                  15      


Ala His His Lys Thr Tyr Asp Asp Ser Tyr Ser Asp Phe Val Arg Phe 
            20                  25                  30          


Arg Pro Pro Val Arg Glu Gly Pro Val Thr Arg Ser Ala Ser Arg Ala 
        35                  40                  45              


Ala Ser Leu His Ser Leu Ser Asp Ala Ser Ser Asp Ser Phe Asn His 
    50                  55                  60                  


Ser Pro Glu Ser Val Asp Thr Lys Leu Asn Phe Ser Asn Leu Leu Met 
65                  70                  75                  80  


Met Tyr Gln Asp Ser Gly Ser Pro Asp Ser Ser Glu Glu Asp Gln Gln 
                85                  90                  95      


Ser Arg Leu Ser Met Leu Pro His Leu Ala Asp Leu Val Ser Tyr Ser 
            100                 105                 110         


Ile Gln Lys Val Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Arg Asp 
        115                 120                 125             


Leu Thr Ala Glu Asp Gln Ile Ala Leu Leu Lys Ser Ser Ala Ile Glu 
    130                 135                 140                 


Ile Ile Met Leu Arg Ser Asn Gln Ser Phe Ser Leu Glu Asp Met Ser 
145                 150                 155                 160 


Trp Ser Cys Gly Gly Pro Asp Phe Lys Tyr Cys Ile Asn Asp Val Thr 
                165                 170                 175     


Lys Ala Gly His Thr Leu Glu Leu Leu Glu Pro Leu Val Lys Phe Gln 
            180                 185                 190         


Val Gly Leu Lys Lys Leu Lys Leu His Glu Glu Glu His Val Leu Leu 
        195                 200                 205             


Met Ala Ile Cys Leu Leu Ser Pro Asp Arg Pro Gly Val Gln Asp His 
    210                 215                 220                 


Val Arg Ile Glu Ala Leu Gln Asp Arg Leu Cys Asp Val Leu Gln Ala 
225                 230                 235                 240 


Tyr Ile Arg Ile Gln His Pro Gly Gly Arg Leu Leu Tyr Ala Lys Met 
                245                 250                 255     


Ile Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn Glu Glu His Ser Lys 
            260                 265                 270         


Gln Tyr Arg Ser Leu Ser Phe Gln Pro Glu His Ser Met Gln Leu Thr 
        275                 280                 285             


Pro Leu Val Leu Glu Val Phe Gly Ser Glu Val Ser 
    290                 295                 300 


<210>  22
<211>  282
<212>  PRT
<213>  Petromyzon marinus

<400>  22

Pro Gln Leu Leu Glu Glu Gln Glu Arg Leu Ile Ala Thr Leu Ile Glu 
1               5                   10                  15      


Ala His Arg Lys Thr Tyr Asp Ala Ser Tyr Ser Asp Phe Ser Gln Phe 
            20                  25                  30          


Arg Pro Pro Lys Arg Gly Asp Gly Ser Pro Glu Cys Arg Asn Ala Thr 
        35                  40                  45              


Asn Pro Phe Leu Met Ser Leu Leu Asn Ser Asp Met Asp Glu Leu Pro 
    50                  55                  60                  


Lys Ala Ser Ala Ser Gly Ala Glu Ala Ala Ala Gly Asp Glu Leu Ser 
65                  70                  75                  80  


Met Leu Pro His Leu Ala Asp Leu Val Ser Tyr Ser Ile Gln Lys Val 
                85                  90                  95      


Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Lys Glu Leu Cys Thr Glu 
            100                 105                 110         


Asp Gln Ile Ser Leu Leu Lys Ala Ser Ala Ile Glu Ile Ile Ile Leu 
        115                 120                 125             


Arg Ser Asn Glu Ser Phe Thr Met Glu Asp Asn Ser Trp Thr Cys Gly 
    130                 135                 140                 


Ser Asn Glu Phe Lys Tyr Gln Ile Gly Asp Val Met Gln Ala Gly His 
145                 150                 155                 160 


Lys Leu Glu Leu Leu Glu Pro Leu Val Lys Phe Gln Val Asn Met Lys 
                165                 170                 175     


Lys Leu Asp Leu His Glu Ala Glu His Val Leu Leu Met Ala Ile Cys 
            180                 185                 190         


Leu Phe Ser Pro Asp Arg Pro Gly Val Gln Asp Arg Cys Arg Val Glu 
        195                 200                 205             


Glu Val Gln Glu His Leu Thr Glu Thr Leu Arg Ala Tyr Ile Ala Cys 
    210                 215                 220                 


Arg His Pro Leu Ser Cys Lys His Met Leu Tyr Thr Lys Met Val Glu 
225                 230                 235                 240 


Lys Leu Thr Glu Leu Arg Ser Leu Asn Glu Glu His Ser Lys Gln Tyr 
                245                 250                 255     


Leu Gln Ile Ser Gln Asp Ala Val Asn Lys Glu Asp Leu Pro Pro Leu 
            260                 265                 270         


Leu Leu Glu Val Phe Gly Asn Pro Thr Ala 
        275                 280         


<210>  23
<211>  303
<212>  PRT
<213>  Ciona intestinalis

<400>  23

Thr Arg Met Thr Met Asp Glu Lys Leu Leu Val Lys Thr Leu Leu Lys 
1               5                   10                  15      


Gly His Arg Asp Ser Tyr Asp Phe Ala Tyr Val Glu Tyr Asp Thr Phe 
            20                  25                  30          


Arg Gly Arg Glu Pro Gly Ser Asn Asp Gly Gln Gln Glu Ile Gly Asn 
        35                  40                  45              


Asn Thr Glu Asn Pro Asn Gly Leu Asp Ala Ala Thr Ala Val Glu Ala 
    50                  55                  60                  


Gln Ser Thr Thr Glu Asp Ser Gly Lys Gln Leu His Leu Met Leu Leu 
65                  70                  75                  80  


Phe Gln His Phe Leu Pro Ile Tyr Pro Phe Ser Phe Asp Pro Lys Ala 
                85                  90                  95      


Lys Gln Leu Phe Gln His Phe Cys Asp Ile Met Thr Trp Gly Ile Arg 
            100                 105                 110         


Lys Val Ile Asp Tyr Cys Lys Gly Ile Pro Gln Phe Val Gln Leu Ser 
        115                 120                 125             


Ile Val Asp Gln Ile Val Leu Leu Arg Gly Gly Cys Leu Glu Met Leu 
    130                 135                 140                 


Val Leu Arg Ser Tyr Phe Ala Phe Ser Cys Asn Glu Asn Lys Tyr Met 
145                 150                 155                 160 


Ser Asp Lys Phe Gln Tyr Lys Pro Ser Asp Phe Leu Gln Ala Gly Gly 
                165                 170                 175     


Asn Lys Glu Phe Val Glu Lys Tyr Asn Ser Leu His Ile Arg Met Arg 
            180                 185                 190         


Lys Met Lys Leu Gln Val Glu Glu Ile Cys Leu Leu Leu Ala Leu Val 
        195                 200                 205             


Leu Phe Ser Pro Asp Arg Pro Gly Leu Glu Asp Gln Ala Lys Val Glu 
    210                 215                 220                 


Gln Met Gln Asp Cys Val Ala Asn Thr Leu Gln Ala Tyr Glu Tyr Thr 
225                 230                 235                 240 


His Lys Pro Pro Asn Glu Ser Ser Phe Leu Gln Ala Arg Thr Met Tyr 
                245                 250                 255     


Cys Glu Leu Leu Leu Ile Leu Pro Ile Leu Arg Thr Ile Asn Met Leu 
            260                 265                 270         


Phe Ala Gln Asn Ile Met Ser Leu Lys Gln Thr Asn Glu Lys Asp Met 
        275                 280                 285             


Asn Pro Leu Ile Leu Glu Val Asn Asn Ser Ala Asp Asp Glu Asp 
    290                 295                 300             


<210>  24
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  24

Val Gln Leu Ser Lys Glu Gln Glu Glu Leu Ile Arg Thr Leu Leu Gly 
1               5                   10                  15      


Ala His Thr Arg His Met Gly Thr Met Phe Glu Gln Phe Val Gln Phe 
            20                  25                  30          


Arg Pro Pro Ala His Leu Phe Ile His His Gln Pro Leu Pro Thr Leu 
        35                  40                  45              


Ala Pro Val Leu Pro Leu Val Thr His Phe Ala Asp Ile Asn Thr Phe 
    50                  55                  60                  


Met Val Leu Gln Val Ile Lys Phe Thr Lys Asp Leu Pro Val Phe Arg 
65                  70                  75                  80  


Ser Leu Pro Ile Glu Asp Gln Ile Ser Leu Leu Lys Gly Ala Ala Val 
                85                  90                  95      


Glu Ile Cys His Ile Val Leu Asn Thr Thr Phe Cys Leu Gln Thr Gln 
            100                 105                 110         


Asn Phe Leu Cys Gly Pro Leu Arg Tyr Thr Ile Glu Asp Gly Ala Arg 
        115                 120                 125             


Val Gly Phe Gln Val Glu Phe Leu Glu Leu Leu Phe His Phe His Gly 
    130                 135                 140                 


Thr Leu Arg Lys Leu Gln Leu Gln Glu Pro Glu Tyr Val Leu Leu Ala 
145                 150                 155                 160 


Ala Met Ala Leu Phe Ser Pro Asp Arg Pro Gly Val Thr Gln Arg Asp 
                165                 170                 175     


Glu Ile Asp Gln Leu Gln Glu Glu Met Ala Leu Thr Leu Gln Ser Tyr 
            180                 185                 190         


Ile Lys Gly Gln Gln Arg Arg Pro Arg Asp Arg Phe Leu Tyr Ala Lys 
        195                 200                 205             


Leu Leu Gly Leu Leu Ala Glu Leu Arg Ser Ile Asn Glu Ala Tyr Gly 
    210                 215                 220                 


Tyr Gln Ile Gln His Ile Gln Gly Leu Ser Ala Met Met Pro Leu Leu 
225                 230                 235                 240 


Gln Glu Ile Cys Ser 
                245 


