                         SEQUENCE LISTING

<110>  Novartis Forschungsstiftung, Zweigniederlassung Friedrich 
       Miescher Institute for Biomedical Research
 
<120>  Experimental models of muscular dystrophy

<130>  53592

<160>  3     

<170>  PatentIn version 3.3

<210>  1
<211>  1008
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Tyr Asp Tyr His Gln Asn Trp Gly Arg Asp Gly Gly Pro Arg 
1               5                   10                  15      


Ser Ser Gly Gly Gly Tyr Gly Gly Gly Pro Ala Gly Gly His Gly Gly 
            20                  25                  30          


Asn Arg Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Gly 
        35                  40                  45              


Gly Arg Gly Arg His Pro Gly His Leu Lys Gly Arg Glu Ile Gly Met 
    50                  55                  60                  


Trp Tyr Ala Lys Lys Gln Gly Gln Lys Asn Lys Glu Ala Glu Arg Gln 
65                  70                  75                  80  


Glu Arg Ala Val Val His Met Asp Glu Arg Arg Glu Glu Gln Ile Val 
                85                  90                  95      


Gln Leu Leu Asn Ser Val Gln Ala Lys Asn Asp Lys Glu Ser Glu Ala 
            100                 105                 110         


Gln Ile Ser Trp Phe Ala Pro Glu Asp His Gly Tyr Gly Thr Glu Val 
        115                 120                 125             


Ser Thr Lys Asn Thr Pro Cys Ser Glu Asn Lys Leu Asp Ile Gln Glu 
    130                 135                 140                 


Lys Lys Leu Ile Asn Gln Glu Lys Lys Met Phe Arg Ile Arg Asn Arg 
145                 150                 155                 160 


Ser Tyr Ile Asp Arg Asp Ser Glu Tyr Leu Leu Gln Glu Asn Glu Pro 
                165                 170                 175     


Asp Gly Thr Leu Asp Gln Lys Leu Leu Glu Asp Leu Gln Lys Lys Lys 
            180                 185                 190         


Asn Asp Leu Arg Tyr Ile Glu Met Gln His Phe Arg Glu Lys Leu Pro 
        195                 200                 205             


Ser Tyr Gly Met Gln Lys Glu Leu Val Asn Leu Ile Asp Asn His Gln 
    210                 215                 220                 


Val Thr Val Ile Ser Gly Glu Thr Gly Cys Gly Lys Thr Thr Gln Val 
225                 230                 235                 240 


Thr Gln Phe Ile Leu Asp Asn Tyr Ile Glu Arg Gly Lys Gly Ser Ala 
                245                 250                 255     


Cys Arg Ile Val Cys Thr Gln Pro Arg Arg Ile Ser Ala Ile Ser Val 
            260                 265                 270         


Ala Glu Arg Val Ala Ala Glu Arg Ala Glu Ser Cys Gly Ser Gly Asn 
        275                 280                 285             


Ser Thr Gly Tyr Gln Ile Arg Leu Gln Ser Arg Leu Pro Arg Lys Gln 
    290                 295                 300                 


Gly Ser Ile Leu Tyr Cys Thr Thr Gly Ile Ile Leu Gln Trp Leu Gln 
305                 310                 315                 320 


Ser Asp Pro Tyr Leu Ser Ser Val Ser His Ile Val Leu Asp Glu Ile 
                325                 330                 335     


His Glu Arg Asn Leu Gln Ser Asp Val Leu Met Thr Val Val Lys Asp 
            340                 345                 350         


Leu Leu Asn Phe Arg Ser Asp Leu Lys Val Ile Leu Met Ser Ala Thr 
        355                 360                 365             


Leu Asn Ala Glu Lys Phe Ser Glu Tyr Phe Gly Asn Cys Pro Met Ile 
    370                 375                 380                 


His Ile Pro Gly Phe Thr Phe Pro Val Val Glu Tyr Leu Leu Glu Asp 
385                 390                 395                 400 


Val Ile Glu Lys Ile Arg Tyr Val Pro Glu Gln Lys Glu His Arg Ser 
                405                 410                 415     


Gln Phe Lys Arg Gly Phe Met Gln Gly His Val Asn Arg Gln Glu Lys 
            420                 425                 430         


Glu Glu Lys Glu Ala Ile Tyr Lys Glu Arg Trp Pro Asp Tyr Val Arg 
        435                 440                 445             


Glu Leu Arg Arg Arg Tyr Ser Ala Ser Thr Val Asp Val Ile Glu Met 
    450                 455                 460                 


Met Glu Asp Asp Lys Val Asp Leu Asn Leu Ile Val Ala Leu Ile Arg 
465                 470                 475                 480 


Tyr Ile Val Leu Glu Glu Glu Asp Gly Ala Ile Leu Val Phe Leu Pro 
                485                 490                 495     


Gly Trp Asp Asn Ile Ser Thr Leu His Asp Leu Leu Met Ser Gln Val 
            500                 505                 510         


Met Phe Lys Ser Asp Lys Phe Leu Ile Ile Pro Leu His Ser Leu Met 
        515                 520                 525             


Pro Thr Val Asn Gln Thr Gln Val Phe Lys Arg Thr Pro Pro Gly Val 
    530                 535                 540                 


Arg Lys Ile Val Ile Ala Thr Asn Ile Ala Glu Thr Ser Ile Thr Ile 
545                 550                 555                 560 


Asp Asp Val Val Tyr Val Ile Asp Gly Gly Lys Ile Lys Glu Thr His 
                565                 570                 575     


Phe Asp Thr Gln Asn Asn Ile Ser Thr Met Ser Ala Glu Trp Val Ser 
            580                 585                 590         


Lys Ala Asn Ala Lys Gln Arg Lys Gly Arg Ala Gly Arg Val Gln Pro 
        595                 600                 605             


Gly His Cys Tyr His Leu Tyr Asn Gly Leu Arg Ala Ser Leu Leu Asp 
    610                 615                 620                 


Asp Tyr Gln Leu Pro Glu Ile Leu Arg Thr Pro Leu Glu Glu Leu Cys 
625                 630                 635                 640 


Leu Gln Ile Lys Ile Leu Arg Leu Gly Gly Ile Ala Tyr Phe Leu Ser 
                645                 650                 655     


Arg Leu Met Asp Pro Pro Ser Asn Glu Ala Val Leu Leu Ser Ile Arg 
            660                 665                 670         


His Leu Met Glu Leu Asn Ala Leu Asp Lys Gln Glu Glu Leu Thr Pro 
        675                 680                 685             


Leu Gly Val His Leu Ala Arg Leu Pro Val Glu Pro His Ile Gly Lys 
    690                 695                 700                 


Met Ile Leu Phe Gly Ala Leu Phe Cys Cys Leu Asp Pro Val Leu Thr 
705                 710                 715                 720 


Ile Ala Ala Ser Leu Ser Phe Lys Asp Pro Phe Val Ile Pro Leu Gly 
                725                 730                 735     


Lys Glu Lys Ile Ala Asp Ala Arg Arg Lys Glu Leu Ala Lys Asp Thr 
            740                 745                 750         


Arg Ser Asp His Leu Thr Val Val Asn Ala Phe Glu Gly Trp Glu Glu 
        755                 760                 765             


Ala Arg Arg Arg Gly Phe Arg Tyr Glu Lys Asp Tyr Cys Trp Glu Tyr 
    770                 775                 780                 


Phe Leu Ser Ser Asn Thr Leu Gln Met Leu His Asn Met Lys Gly Gln 
785                 790                 795                 800 


Phe Ala Glu His Leu Leu Gly Ala Gly Phe Val Ser Ser Arg Asn Pro 
                805                 810                 815     


Lys Asp Pro Glu Ser Asn Ile Asn Ser Asp Asn Glu Lys Ile Ile Lys 
            820                 825                 830         


Ala Val Ile Cys Ala Gly Leu Tyr Pro Lys Val Ala Lys Ile Arg Leu 
        835                 840                 845             


Asn Leu Gly Lys Lys Arg Lys Met Val Lys Val Tyr Thr Lys Thr Asp 
    850                 855                 860                 


Gly Leu Val Ala Val His Pro Lys Ser Val Asn Val Glu Gln Thr Asp 
865                 870                 875                 880 


Phe His Tyr Asn Trp Leu Ile Tyr His Leu Lys Met Arg Thr Ser Ser 
                885                 890                 895     


Ile Tyr Leu Tyr Asp Cys Thr Glu Val Ser Pro Tyr Cys Leu Leu Phe 
            900                 905                 910         


Phe Gly Gly Asp Ile Ser Ile Gln Lys Asp Asn Asp Gln Glu Thr Ile 
        915                 920                 925             


Ala Val Asp Glu Trp Ile Val Phe Gln Ser Pro Ala Arg Ile Ala His 
    930                 935                 940                 


Leu Val Lys Glu Leu Arg Lys Glu Leu Asp Ile Leu Leu Gln Glu Lys 
945                 950                 955                 960 


Ile Glu Ser Pro His Pro Val Asp Trp Asn Asp Thr Lys Ser Arg Asp 
                965                 970                 975     


Cys Ala Val Leu Ser Ala Ile Ile Asp Leu Ile Lys Thr Gln Glu Lys 
            980                 985                 990         


Ala Thr Pro Arg Asn Phe Pro Pro  Arg Phe Gln Asp Gly  Tyr Tyr Ser 
        995                 1000                 1005             


<210>  2
<211>  994
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Tyr Asp Tyr His Gln Asn Trp Gly Arg Asp Gly Gly Pro Arg 
1               5                   10                  15      


Ser Ser Gly Gly Gly Tyr Gly Gly Gly Pro Ala Gly Gly His Gly Gly 
            20                  25                  30          


Asn Arg Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Gly 
        35                  40                  45              


Gly Arg Gly Arg His Pro Gly His Leu Lys Gly Arg Glu Ile Gly Met 
    50                  55                  60                  


Trp Tyr Ala Lys Lys Gln Gly Gln Lys Asn Lys Glu Ala Glu Arg Gln 
65                  70                  75                  80  


Glu Arg Ala Val Val His Met Asp Glu Arg Arg Glu Glu Gln Ile Val 
                85                  90                  95      


Gln Leu Leu Asn Ser Val Gln Ala Lys Asn Asp Lys Glu Ser Glu Ala 
            100                 105                 110         


Gln Ile Ser Trp Phe Ala Pro Glu Asp His Gly Tyr Gly Thr Glu Val 
        115                 120                 125             


Ser Thr Lys Asn Thr Pro Cys Ser Glu Asn Lys Leu Asp Ile Gln Glu 
    130                 135                 140                 


Lys Lys Leu Ile Asn Gln Glu Lys Lys Met Phe Arg Ile Arg Asn Arg 
145                 150                 155                 160 


Ser Tyr Ile Asp Arg Asp Ser Glu Tyr Leu Leu Gln Glu Asn Glu Pro 
                165                 170                 175     


Asp Gly Thr Leu Asp Gln Lys Leu Leu Glu Asp Leu Gln Lys Lys Lys 
            180                 185                 190         


Asn Asp Leu Arg Tyr Ile Glu Met Gln His Phe Arg Glu Lys Leu Pro 
        195                 200                 205             


Ser Tyr Gly Met Gln Lys Glu Leu Val Asn Leu Ile Asp Asn His Gln 
    210                 215                 220                 


Val Thr Val Ile Ser Gly Glu Thr Gly Cys Gly Lys Thr Thr Gln Val 
225                 230                 235                 240 


Thr Gln Phe Ile Leu Asp Asn Tyr Ile Glu Arg Gly Lys Gly Ser Ala 
                245                 250                 255     


Cys Arg Ile Val Cys Thr Gln Pro Arg Arg Ile Ser Ala Ile Ser Val 
            260                 265                 270         


Ala Glu Arg Val Ala Ala Glu Arg Ala Glu Ser Cys Gly Ser Gly Asn 
        275                 280                 285             


Ser Thr Gly Tyr Gln Ile Arg Leu Gln Ser Arg Leu Pro Arg Lys Gln 
    290                 295                 300                 


Gly Ser Ile Leu Tyr Cys Thr Thr Gly Ile Ile Leu Gln Trp Leu Gln 
305                 310                 315                 320 


Ser Asp Pro Tyr Leu Ser Ser Val Ser His Ile Val Leu Asp Glu Ile 
                325                 330                 335     


His Glu Arg Asn Leu Gln Ser Asp Val Leu Met Thr Val Val Lys Asp 
            340                 345                 350         


Leu Leu Asn Phe Arg Ser Asp Leu Lys Val Ile Leu Met Ser Ala Thr 
        355                 360                 365             


Leu Asn Ala Glu Lys Phe Ser Glu Tyr Phe Gly Asn Cys Pro Met Ile 
    370                 375                 380                 


His Ile Pro Gly Phe Thr Phe Pro Val Val Glu Tyr Leu Leu Glu Asp 
385                 390                 395                 400 


Val Ile Glu Lys Ile Arg Tyr Val Pro Glu Gln Lys Glu His Arg Ser 
                405                 410                 415     


Gln Phe Lys Arg Gly Phe Met Gln Gly His Val Asn Arg Gln Glu Lys 
            420                 425                 430         


Glu Glu Lys Glu Ala Ile Tyr Lys Glu Arg Trp Pro Asp Tyr Val Arg 
        435                 440                 445             


Glu Leu Arg Arg Arg Tyr Ser Ala Ser Thr Val Asp Val Ile Glu Met 
    450                 455                 460                 


Met Glu Asp Asp Lys Val Asp Leu Asn Leu Ile Val Ala Leu Ile Arg 
465                 470                 475                 480 


Tyr Ile Val Leu Glu Glu Glu Asp Gly Ala Ile Leu Val Phe Leu Pro 
                485                 490                 495     


Gly Trp Asp Asn Ile Ser Thr Leu His Asp Leu Leu Met Ser Gln Val 
            500                 505                 510         


Met Phe Lys Ser Val Asn Gln Thr Gln Val Phe Lys Arg Thr Pro Pro 
        515                 520                 525             


Gly Val Arg Lys Ile Val Ile Ala Thr Asn Ile Ala Glu Thr Ser Ile 
    530                 535                 540                 


Thr Ile Asp Asp Val Val Tyr Val Ile Asp Gly Gly Lys Ile Lys Glu 
545                 550                 555                 560 


Thr His Phe Asp Thr Gln Asn Asn Ile Ser Thr Met Ser Ala Glu Trp 
                565                 570                 575     


Val Ser Lys Ala Asn Ala Lys Gln Arg Lys Gly Arg Ala Gly Arg Val 
            580                 585                 590         


Gln Pro Gly His Cys Tyr His Leu Tyr Asn Gly Leu Arg Ala Ser Leu 
        595                 600                 605             


Leu Asp Asp Tyr Gln Leu Pro Glu Ile Leu Arg Thr Pro Leu Glu Glu 
    610                 615                 620                 


Leu Cys Leu Gln Ile Lys Ile Leu Arg Leu Gly Gly Ile Ala Tyr Phe 
625                 630                 635                 640 


Leu Ser Arg Leu Met Asp Pro Pro Ser Asn Glu Ala Val Leu Leu Ser 
                645                 650                 655     


Ile Arg His Leu Met Glu Leu Asn Ala Leu Asp Lys Gln Glu Glu Leu 
            660                 665                 670         


Thr Pro Leu Gly Val His Leu Ala Arg Leu Pro Val Glu Pro His Ile 
        675                 680                 685             


Gly Lys Met Ile Leu Phe Gly Ala Leu Phe Cys Cys Leu Asp Pro Val 
    690                 695                 700                 


Leu Thr Ile Ala Ala Ser Leu Ser Phe Lys Asp Pro Phe Val Ile Pro 
705                 710                 715                 720 


Leu Gly Lys Glu Lys Ile Ala Asp Ala Arg Arg Lys Glu Leu Ala Lys 
                725                 730                 735     


Asp Thr Arg Ser Asp His Leu Thr Val Val Asn Ala Phe Glu Gly Trp 
            740                 745                 750         


Glu Glu Ala Arg Arg Arg Gly Phe Arg Tyr Glu Lys Asp Tyr Cys Trp 
        755                 760                 765             


Glu Tyr Phe Leu Ser Ser Asn Thr Leu Gln Met Leu His Asn Met Lys 
    770                 775                 780                 


Gly Gln Phe Ala Glu His Leu Leu Gly Ala Gly Phe Val Ser Ser Arg 
785                 790                 795                 800 


Asn Pro Lys Asp Pro Glu Ser Asn Ile Asn Ser Asp Asn Glu Lys Ile 
                805                 810                 815     


Ile Lys Ala Val Ile Cys Ala Gly Leu Tyr Pro Lys Val Ala Lys Ile 
            820                 825                 830         


Arg Leu Asn Leu Gly Lys Lys Arg Lys Met Val Lys Val Tyr Thr Lys 
        835                 840                 845             


Thr Asp Gly Leu Val Ala Val His Pro Lys Ser Val Asn Val Glu Gln 
    850                 855                 860                 


Thr Asp Phe His Tyr Asn Trp Leu Ile Tyr His Leu Lys Met Arg Thr 
865                 870                 875                 880 


Ser Ser Ile Tyr Leu Tyr Asp Cys Thr Glu Val Ser Pro Tyr Cys Leu 
                885                 890                 895     


Leu Phe Phe Gly Gly Asp Ile Ser Ile Gln Lys Asp Asn Asp Gln Glu 
            900                 905                 910         


Thr Ile Ala Val Asp Glu Trp Ile Val Phe Gln Ser Pro Ala Arg Ile 
        915                 920                 925             


Ala His Leu Val Lys Glu Leu Arg Lys Glu Leu Asp Ile Leu Leu Gln 
    930                 935                 940                 


Glu Lys Ile Glu Ser Pro His Pro Val Asp Trp Asn Asp Thr Lys Ser 
945                 950                 955                 960 


Arg Asp Cys Ala Val Leu Ser Ala Ile Ile Asp Leu Ile Lys Thr Gln 
                965                 970                 975     


Glu Lys Ala Thr Pro Arg Asn Phe Pro Pro Arg Phe Gln Asp Gly Tyr 
            980                 985                 990         


Tyr Ser 
        


<210>  3
<211>  1001
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ser Tyr Asp Tyr His Gln Ser Trp Ser Arg Asp Gly Gly Pro Arg 
1               5                   10                  15      


Gly Ser Gly Gln Gly Ser Ser Gly Gly Gly Gly Gly Gly Ser Arg Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Gly Gly Arg Gly Gly Arg Gly Arg His Pro Ala 
        35                  40                  45              


His Leu Lys Gly Arg Glu Ile Gly Leu Trp Tyr Ala Lys Lys Gln Thr 
    50                  55                  60                  


Gln Lys Asn Lys Glu Ala Glu Arg Gln Glu Arg Ala Val Val His Met 
65                  70                  75                  80  


Asp Glu Arg Arg Glu Glu Gln Ile Val Gln Leu Leu Asn Ser Val Gln 
                85                  90                  95      


Ala Lys Thr Asp Lys Asp Ser Glu Ala Gln Ile Ser Trp Phe Ala Pro 
            100                 105                 110         


Glu Asp His Gly Tyr Gly Thr Glu Val Ser Ser Glu Lys Lys Ile Asn 
        115                 120                 125             


Ser Glu Lys Lys Leu Asp Asn Gln Glu Lys Lys Leu Leu Asn Gln Glu 
    130                 135                 140                 


Lys Lys Thr Phe Arg Ile Thr Asp Lys Ser Tyr Ile Asp Arg Asp Ser 
145                 150                 155                 160 


Glu Tyr Leu Leu Gln Glu Asn Glu Pro Asn Leu Ser Leu Asp Gln His 
                165                 170                 175     


Leu Leu Glu Asp Leu Gln Arg Lys Lys Thr Asp Pro Arg Tyr Ile Glu 
            180                 185                 190         


Met Gln Arg Phe Arg Lys Lys Leu Pro Ser Tyr Gly Met Gln Lys Glu 
        195                 200                 205             


Leu Val Asn Leu Ile Asn Asn His Gln Val Thr Val Ile Ser Gly Glu 
    210                 215                 220                 


Thr Gly Cys Gly Lys Thr Thr Gln Val Thr Gln Phe Ile Leu Asp Asn 
225                 230                 235                 240 


Tyr Ile Glu Arg Gly Lys Gly Ser Ala Cys Arg Ile Val Cys Thr Gln 
                245                 250                 255     


Pro Arg Arg Ile Ser Ala Ile Ser Val Ala Glu Arg Val Ala Thr Glu 
            260                 265                 270         


Arg Ala Glu Ser Cys Gly Asn Gly Asn Ser Thr Gly Tyr Gln Ile Arg 
        275                 280                 285             


Leu Gln Ser Arg Leu Pro Arg Lys Gln Gly Ser Ile Leu Tyr Cys Thr 
    290                 295                 300                 


Thr Gly Ile Ile Leu Gln Trp Leu Gln Ser Asp Ser Arg Leu Ser Ser 
305                 310                 315                 320 


Val Ser His Ile Val Leu Asp Glu Ile His Glu Arg Asn Leu Gln Ser 
                325                 330                 335     


Asp Val Leu Met Thr Val Ile Lys Asp Leu Leu His Phe Arg Ser Asp 
            340                 345                 350         


Leu Lys Val Ile Leu Met Ser Ala Thr Leu Asn Ala Glu Lys Phe Ser 
        355                 360                 365             


Glu Tyr Phe Gly Asn Cys Pro Met Ile His Ile Pro Gly Phe Thr Phe 
    370                 375                 380                 


Pro Val Val Glu Tyr Leu Leu Glu Asp Ile Ile Glu Lys Ile Arg Tyr 
385                 390                 395                 400 


Val Pro Asp Gln Lys Glu His Arg Ser Gln Phe Lys Arg Gly Phe Met 
                405                 410                 415     


Gln Gly His Val Asn Arg Gln Glu Lys Glu Glu Lys Glu Ala Ile Tyr 
            420                 425                 430         


Lys Glu Arg Trp Pro Ala Tyr Ile Lys Glu Leu Arg Thr Arg Tyr Ser 
        435                 440                 445             


Ala Ser Thr Val Asp Val Leu Gln Met Met Asp Asp Asp Lys Val Asp 
    450                 455                 460                 


Leu Asn Leu Ile Ala Ala Leu Ile Arg Tyr Ile Val Leu Glu Glu Glu 
465                 470                 475                 480 


Asp Gly Ala Ile Leu Val Phe Leu Pro Gly Trp Asp Asn Ile Ser Thr 
                485                 490                 495     


Leu His Asp Leu Leu Met Ser Gln Val Met Phe Lys Ser Asp Lys Phe 
            500                 505                 510         


Leu Ile Ile Pro Leu His Ser Leu Met Pro Thr Val Asn Gln Thr Gln 
        515                 520                 525             


Val Phe Lys Lys Thr Pro Pro Gly Val Arg Lys Ile Val Ile Ala Thr 
    530                 535                 540                 


Asn Ile Ala Glu Thr Ser Ile Thr Ile Asp Asp Val Val Tyr Val Ile 
545                 550                 555                 560 


Asp Gly Gly Lys Ile Lys Glu Thr His Phe Asp Thr Gln Asn Asn Ile 
                565                 570                 575     


Ser Thr Met Ser Ala Glu Trp Val Ser Lys Ala Asn Ala Lys Gln Arg 
            580                 585                 590         


Lys Gly Arg Ala Gly Arg Val Gln Pro Gly His Cys Tyr His Leu Tyr 
        595                 600                 605             


Asn Gly Leu Arg Ala Ser Leu Leu Asp Asp Tyr Gln Leu Pro Glu Ile 
    610                 615                 620                 


Leu Arg Thr Pro Leu Glu Glu Leu Cys Leu Gln Ile Lys Ile Leu Arg 
625                 630                 635                 640 


Leu Gly Gly Ile Ala Tyr Phe Leu Ser Arg Leu Met Asp Pro Pro Ser 
                645                 650                 655     


Asn Glu Ala Val Val Leu Ser Ile Lys His Leu Met Glu Leu Ser Ala 
            660                 665                 670         


Leu Asp Lys Gln Glu Glu Leu Thr Pro Leu Gly Val His Leu Ala Arg 
        675                 680                 685             


Leu Pro Val Glu Pro His Ile Gly Lys Met Ile Leu Phe Gly Ala Leu 
    690                 695                 700                 


Phe Cys Cys Leu Asp Pro Val Leu Thr Ile Ala Ala Ser Leu Ser Phe 
705                 710                 715                 720 


Lys Asp Pro Phe Val Ile Pro Leu Gly Lys Glu Lys Ile Ala Asp Ala 
                725                 730                 735     


Arg Arg Lys Glu Leu Ala Lys Glu Thr Arg Ser Asp His Leu Thr Val 
            740                 745                 750         


Val Asn Ala Phe Glu Gly Trp Glu Glu Ala Lys Arg Arg Gly Phe Arg 
        755                 760                 765             


Tyr Glu Lys Asp Tyr Cys Trp Glu Tyr Phe Leu Ser Ser Asn Thr Leu 
    770                 775                 780                 


Gln Met Leu His Asn Met Lys Gly Gln Phe Ala Glu His Leu Leu Gly 
785                 790                 795                 800 


Ala Gly Phe Val Ser Ser Arg Ser Pro Lys Asp Pro Lys Ala Asn Ile 
                805                 810                 815     


Asn Ser Asp Asn Glu Lys Ile Ile Lys Ala Val Ile Cys Ala Gly Leu 
            820                 825                 830         


Tyr Pro Lys Val Ala Lys Ile Arg Leu Asn Leu Gly Lys Lys Arg Lys 
        835                 840                 845             


Met Val Lys Val His Thr Lys Ser Asp Gly Leu Val Ser Ile His Pro 
    850                 855                 860                 


Lys Ser Val Asn Val Glu Gln Thr Asp Phe His Tyr Asn Trp Leu Ile 
865                 870                 875                 880 


Tyr His Leu Lys Met Arg Thr Ser Ser Ile Tyr Leu Tyr Asp Cys Thr 
                885                 890                 895     


Glu Val Ser Pro Tyr Cys Leu Leu Phe Phe Gly Gly Asp Ile Ser Ile 
            900                 905                 910         


Gln Lys Asp Lys Asp Gln Glu Ile Ile Ala Val Asp Glu Trp Ile Val 
        915                 920                 925             


Phe Gln Ser Pro Glu Arg Ile Ala His Leu Val Lys Gly Leu Arg Lys 
    930                 935                 940                 


Glu Leu Asp Ser Leu Leu Gln Glu Lys Ile Glu Ser Pro His Pro Val 
945                 950                 955                 960 


Asp Trp Asp Asp Thr Lys Ser Arg Asp Cys Ala Val Leu Ser Ala Ile 
                965                 970                 975     


Leu Asp Leu Ile Lys Thr Gln Lys Lys Ala Thr Pro Arg Asn Leu Pro 
            980                 985                 990         


Pro Arg Ser Gln Asp Gly Tyr Tyr  Ser 
        995                 1000     


