                         SEQUENCE LISTING

<110>  Trustees of Dartmouth College
       Kull, F. Jon
       Cochran, Jared C.
 
<120>  HYBRID PROKARYOTIC-EUKARYOTIC TUBULINS AND USE THEREOF

<130>  DC0418WO

<150>  US 61/173,687
<151>  2009-04-29

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  473
<212>  PRT
<213>  Prosthecobacter dejongeii

<400>  1

Met Lys Val Asn Asn Thr Ile Val Val Ser Ile Gly Gln Ala Gly Asn 
1               5                   10                  15      


Gln Ile Ala Ala Ser Phe Trp Lys Thr Val Cys Leu Glu His Gly Ile 
            20                  25                  30          


Asp Pro Leu Thr Gly Gln Thr Ala Pro Gly Val Ala Pro Arg Gly Asn 
        35                  40                  45              


Trp Ser Ser Phe Phe Ser Lys Leu Gly Glu Ser Ser Ser Gly Ser Tyr 
    50                  55                  60                  


Val Pro Arg Ala Ile Met Val Asp Leu Glu Pro Ser Val Ile Asp Asn 
65                  70                  75                  80  


Val Lys Ala Thr Ser Gly Ser Leu Phe Asn Pro Ala Asn Leu Ile Ser 
                85                  90                  95      


Arg Thr Glu Gly Ala Gly Gly Asn Phe Ala Val Gly Tyr Leu Gly Ala 
            100                 105                 110         


Gly Arg Glu Val Leu Pro Glu Val Met Ser Arg Leu Asp Tyr Glu Ile 
        115                 120                 125             


Asp Lys Cys Asp Asn Val Gly Gly Ile Ile Val Leu His Ala Ile Gly 
    130                 135                 140                 


Gly Gly Thr Gly Ser Gly Phe Gly Ala Leu Leu Ile Glu Ser Leu Lys 
145                 150                 155                 160 


Glu Lys Tyr Gly Glu Ile Pro Val Leu Ser Cys Ala Val Leu Pro Ser 
                165                 170                 175     


Pro Gln Val Ser Ser Val Val Thr Glu Pro Tyr Asn Thr Val Phe Ala 
            180                 185                 190         


Leu Asn Thr Leu Arg Arg Ser Ala Asp Ala Cys Leu Ile Phe Asp Asn 
        195                 200                 205             


Glu Ala Leu Phe Asp Leu Ala His Arg Lys Trp Asn Ile Glu Ser Pro 
    210                 215                 220                 


Thr Val Asp Asp Leu Asn Leu Leu Ile Thr Glu Ala Leu Ala Gly Ile 
225                 230                 235                 240 


Thr Ala Ser Met Arg Phe Ser Gly Phe Leu Thr Val Glu Ile Thr Leu 
                245                 250                 255     


Arg Glu Leu Leu Thr Asn Leu Val Pro Gln Pro Ser Leu His Phe Leu 
            260                 265                 270         


Met Cys Ala Phe Ala Pro Leu Thr Pro Pro Asp Arg Ser Lys Phe Glu 
        275                 280                 285             


Glu Leu Gly Ile Glu Glu Met Ile Lys Ser Leu Phe Asp Asn Gly Ser 
    290                 295                 300                 


Val Phe Ala Ala Cys Ser Pro Met Glu Gly Arg Phe Leu Ser Thr Ala 
305                 310                 315                 320 


Val Leu Tyr Arg Gly Ile Met Glu Asp Lys Pro Leu Ala Asp Ala Ala 
                325                 330                 335     


Leu Ala Ala Met Arg Glu Lys Leu Pro Leu Thr Tyr Trp Ile Pro Thr 
            340                 345                 350         


Ala Phe Lys Ile Gly Tyr Val Glu Gln Pro Gly Ile Ser His Arg Lys 
        355                 360                 365             


Ser Met Val Leu Leu Ala Asn Asn Thr Glu Ile Ala Arg Val Leu Asp 
    370                 375                 380                 


Arg Ile Cys His Asn Phe Asp Lys Leu Trp Gln Arg Lys Ala Phe Ala 
385                 390                 395                 400 


Asn Trp Tyr Leu Asn Glu Gly Met Ser Glu Glu Gln Ile Asn Val Leu 
                405                 410                 415     


Arg Ala Ser Ala Gln Glu Leu Val Gln Ser Tyr Gln Val Ala Glu Glu 
            420                 425                 430         


Ser Gly Ala Lys Ala Lys Val Gln Asp Ser Ala Gly Asp Thr Gly Met 
        435                 440                 445             


Arg Ala Ala Ala Ala Gly Val Ser Asp Asp Ala Arg Gly Ser Met Ser 
    450                 455                 460                 


Leu Arg Asp Leu Val Asp Arg Arg Arg 
465                 470             


<210>  2
<211>  426
<212>  PRT
<213>  Prosthecobacter dejongeii

<400>  2

Val Arg Glu Ile Leu Ser Ile His Val Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Ala Asp Ser Phe Trp Arg Leu Ala Leu Arg Glu His Gly Leu Thr Glu 
            20                  25                  30          


Ala Gly Thr Leu Lys Glu Gly Ser Asn Ala Ala Ala Asn Ser Asn Met 
        35                  40                  45              


Glu Val Phe Phe His Lys Val Arg Asp Gly Lys Tyr Val Pro Arg Ala 
    50                  55                  60                  


Val Leu Val Asp Leu Glu Pro Gly Val Ile Ala Arg Ile Glu Gly Gly 
65                  70                  75                  80  


Asp Met Ser Gln Leu Phe Asp Glu Ser Ser Ile Val Arg Lys Ile Pro 
                85                  90                  95      


Gly Ala Ala Asn Asn Trp Ala Arg Gly Tyr Asn Val Glu Gly Glu Lys 
            100                 105                 110         


Val Ile Asp Gln Ile Met Asn Val Ile Asp Ser Ala Val Glu Lys Thr 
        115                 120                 125             


Lys Gly Leu Gln Gly Phe Leu Met Thr His Ser Ile Gly Gly Gly Ser 
    130                 135                 140                 


Gly Ser Gly Leu Gly Ser Leu Ile Leu Glu Arg Leu Arg Gln Ala Tyr 
145                 150                 155                 160 


Pro Lys Lys Arg Ile Phe Thr Phe Ser Val Val Pro Ser Pro Leu Ile 
                165                 170                 175     


Ser Asp Ser Ala Val Glu Pro Tyr Asn Ala Ile Leu Thr Leu Gln Arg 
            180                 185                 190         


Ile Leu Asp Asn Ala Asp Gly Ala Val Leu Leu Asp Asn Glu Ala Leu 
        195                 200                 205             


Phe Arg Ile Ala Lys Ala Lys Leu Asn Arg Ser Pro Asn Tyr Met Asp 
    210                 215                 220                 


Leu Asn Asn Ile Ile Ala Leu Ile Val Ser Ser Val Thr Ala Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Lys Leu Asn Thr Asp Leu Ser Glu Phe Val Thr Asn 
                245                 250                 255     


Leu Val Pro Phe Pro Gly Asn His Phe Leu Thr Ala Ser Phe Ala Pro 
            260                 265                 270         


Met Arg Gly Ala Gly Gln Glu Gly Gln Val Arg Thr Asn Phe Pro Asp 
        275                 280                 285             


Leu Ala Arg Glu Thr Phe Ala Gln Asp Asn Phe Thr Ala Ala Ile Asp 
    290                 295                 300                 


Trp Gln Gln Gly Val Tyr Leu Ala Ala Ser Ala Leu Phe Arg Gly Asp 
305                 310                 315                 320 


Val Lys Ala Lys Asp Val Asp Glu Asn Met Ala Thr Ile Arg Lys Ser 
                325                 330                 335     


Leu Asn Tyr Ala Ser Tyr Met Pro Ala Ser Gly Gly Leu Lys Leu Gly 
            340                 345                 350         


Tyr Ala Glu Thr Ala Pro Glu Gly Phe Ala Ser Ser Gly Leu Ala Leu 
        355                 360                 365             


Val Asn His Thr Gly Ile Ala Ala Val Phe Glu Arg Leu Ile Ala Gln 
    370                 375                 380                 


Phe Asp Ile Met Phe Asp Asn His Ala Tyr Thr His Trp Tyr Glu Asn 
385                 390                 395                 400 


Ala Gly Val Ser Arg Asp Met Met Ala Lys Ala Arg Asn Gln Ile Ala 
                405                 410                 415     


Thr Leu Ala Gln Ser Tyr Arg Asp Ala Ser 
            420                 425     


<210>  3
<211>  471
<212>  PRT
<213>  Prosthecobacter vanneervenii

<400>  3

Met Lys Val Asn Asn Thr Ile Val Ile Ser Ile Gly Gln Ala Gly Asn 
1               5                   10                  15      


Gln Ile Ala Ala Ser Phe Trp Lys Thr Ile Cys Gln Glu His Gly Ile 
            20                  25                  30          


Asp Pro Met Thr Gly Gln Thr Ala Gln Gly Gln Ala Pro Arg Gly Asn 
        35                  40                  45              


Trp Ser Ala Phe Phe Thr Lys Leu Gly Glu Ser Thr Ser Gly Ser Tyr 
    50                  55                  60                  


Val Pro Arg Ala Val Met Val Asp Leu Glu Pro Ser Val Ile Asp Asn 
65                  70                  75                  80  


Ile Lys Ala Thr Ser Gly Ser Leu Phe Asn Pro Gly Asn Leu Ile Ser 
                85                  90                  95      


Arg Thr Glu Gly Ala Gly Gly Asn Phe Ala Val Gly Tyr Leu Gly Ala 
            100                 105                 110         


Gly Arg Glu Val Leu Pro Glu Val Met Ser Arg Leu Asp Ser Glu Ile 
        115                 120                 125             


Asp Lys Cys Asp Asn Val Gly Gly Ile Ile Val Leu His Ala Thr Gly 
    130                 135                 140                 


Gly Gly Ser Gly Ser Gly Phe Gly Ala Leu Leu Ile Glu Ser Ile Lys 
145                 150                 155                 160 


Glu Lys Tyr Pro Glu Phe Pro Val Leu Ser Cys Ala Val Leu Pro Ser 
                165                 170                 175     


Pro Gln Val Ser Ser Val Val Thr Glu Pro Tyr Asn Thr Val Phe Thr 
            180                 185                 190         


Leu Asn Thr Leu Arg Arg Ala Ala Asp Ala Cys Leu Ile Phe Asp Asn 
        195                 200                 205             


Glu Ala Leu Phe Glu Leu Ala His Arg Lys Trp Asn Ile Glu Ser Pro 
    210                 215                 220                 


Thr Val Asp Asp Leu Asn Leu Leu Ile Thr Glu Ala Leu Ala Gly Leu 
225                 230                 235                 240 


Thr Ala Ser Met Arg Phe Ser Gly Phe Leu Thr Val Glu Ile Ser Leu 
                245                 250                 255     


Arg Glu Leu Leu Thr Asn Leu Val Pro Gln Pro Ser Leu His Phe Leu 
            260                 265                 270         


Met Cys Ser Phe Ala Pro Leu Thr Pro Pro Asp Arg Ser Lys Phe Glu 
        275                 280                 285             


Glu Met Gly Val Glu Glu Met Ile Arg Ser Leu Phe Asp Asn Gly Ser 
    290                 295                 300                 


Val Phe Ala Ala Cys Ser Pro Met Glu Gly Arg Phe Leu Ser Thr Ala 
305                 310                 315                 320 


Val Leu Tyr Arg Gly Ile Met Glu Asp Lys Pro Leu Ala Asp Ser Ala 
                325                 330                 335     


Leu Ala Ala Met Arg Glu Gln Leu Pro Leu Thr Tyr Trp Ile Pro Thr 
            340                 345                 350         


Ala Phe Lys Ile Gly Tyr Val Glu Gln Ala Gly Ile Ser His Arg Lys 
        355                 360                 365             


Ser Met Val Leu Leu Ala Asn Asn Thr Glu Ile Ala Arg Val Leu Asp 
    370                 375                 380                 


Arg Ile Cys His Asn Phe Asp Lys Leu Trp Gln Arg Lys Ala Phe Ala 
385                 390                 395                 400 


Asn Trp Tyr Leu Asn Glu Gly Met Ser Glu Glu Gln Ile Asn Ala Leu 
                405                 410                 415     


Arg Ala Ser Ala Gln Glu Leu Ile Gln Ser Tyr Gln Val Ala Glu Glu 
            420                 425                 430         


Ser Gly Ala Lys Ala Lys Val Gln Asp Ser Ser Ala Asp Tyr Pro Arg 
        435                 440                 445             


Ser Ser Ala Ser Ser Asp Asp Ser Arg Ser Gly Met Ser Leu Arg Asp 
    450                 455                 460                 


Leu Val Asp Arg Arg Arg Ala 
465                 470     


<210>  4
<211>  424
<212>  PRT
<213>  Prosthecobacter vanneervenii

<400>  4

Met Arg Glu Ile Leu Ser Ile His Val Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Ala Asp Arg Phe Trp Arg Leu Val Leu Arg Glu His Gly Leu Thr Glu 
            20                  25                  30          


Ala Gly Thr Pro Lys Glu Gly Thr Asn Val Ala Ala Asn Ala Asn Met 
        35                  40                  45              


Glu Val Phe Phe His Lys Val Arg Asp Gly Lys Tyr Ile Pro Arg Ala 
    50                  55                  60                  


Ile Leu Val Asp Leu Glu Pro Gly Val Ile Ala Arg Ile Glu Gly Gly 
65                  70                  75                  80  


Asp Met Ala Gln Leu Phe Asp Glu Ser Cys Ile Ile Arg Lys Ile Pro 
                85                  90                  95      


Gly Ala Ala Asn Asn Trp Ala Arg Gly Tyr Asn Val Glu Gly Glu Arg 
            100                 105                 110         


Ile Ile Asp Gln Ile Met Asn Val Ile Asp Ala Ala Val Glu Lys Thr 
        115                 120                 125             


Lys Ser Leu Gln Gly Phe Leu Leu Thr His Ser Ile Gly Gly Gly Ser 
    130                 135                 140                 


Gly Ser Gly Leu Gly Ser Leu Ile Leu Glu Arg Leu Arg Gln Ala Tyr 
145                 150                 155                 160 


Pro Lys Lys Arg Ile Phe Thr Phe Ser Val Ala Pro Ser Pro Leu Ile 
                165                 170                 175     


Ser Asp Ser Ala Val Glu Pro Tyr Asn Ala Ile Leu Thr Leu Gln Arg 
            180                 185                 190         


Ile Leu Asp Asn Ala Asp Ala Ala Val Leu Leu Asp Asn Glu Ala Leu 
        195                 200                 205             


Phe Arg Ile Ala Lys Ser Lys Leu His Arg Ser Pro Asn Tyr Met Asp 
    210                 215                 220                 


Leu Asn His Ile Ile Ala Leu Ile Met Ser Ser Val Thr Ala Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Lys Leu Asn Thr Asp Leu Gly Glu Tyr Val Thr Asn 
                245                 250                 255     


Leu Val Pro Phe Pro Gly Asn His Phe Leu Thr Ala Ser Phe Ala Pro 
            260                 265                 270         


Met Arg Ala Pro Gly Gln Glu Gly Gln Val Arg Ile Asn Phe Pro Asp 
        275                 280                 285             


Ile Ala Arg Glu Thr Phe Ala Gln Asp Asn Phe Thr Ala Ala Ile Asp 
    290                 295                 300                 


Trp Thr Asn Gly Val Tyr Leu Ser Ala Cys Ala Leu Phe Arg Gly Asp 
305                 310                 315                 320 


Val Lys Ala Lys Glu Val Glu Glu Asn Met Ala Ala Ile Arg Lys Ser 
                325                 330                 335     


Leu Asn Phe Ala Ser Tyr Val Pro Thr Gly Val Lys Leu Gly Val Ala 
            340                 345                 350         


Glu Thr Ala Pro Glu Gly Phe Ala Ser Ser Gly Leu Ala Leu Val Asn 
        355                 360                 365             


His Thr Gly Ile Ala Ala Val Phe Glu Arg Leu Ile Asn Asn Phe Asp 
    370                 375                 380                 


Ile Met Phe Asp Asn His Ala Tyr Thr His Trp Tyr Glu Asn Asn Gly 
385                 390                 395                 400 


Val Ser Arg Asp Met Met Ala His Ala Arg Asn Thr Ile Val Asn Leu 
                405                 410                 415     


Ala Gln Ser Tyr Arg Asp Ala Ser 
            420                 


<210>  5
<211>  470
<212>  PRT
<213>  Prosthecobacter debontii

<400>  5

Met Lys Val Asn Asn Thr Ile Val Val Ser Ile Gly Gln Ala Gly Asn 
1               5                   10                  15      


Gln Ile Ala Ala Ser Phe Trp Lys Thr Ile Cys Gln Glu His Gly Ile 
            20                  25                  30          


Asp Pro Leu Thr Gly Gln Thr Ala Gly Gly Ala Thr Pro Arg Gly Asn 
        35                  40                  45              


Trp Ser Ala Phe Phe Ser Ser Leu Gly Asp Ser Gly Gly Gly Ser Phe 
    50                  55                  60                  


Val Pro Arg Ala Val Met Val Asp Leu Glu Pro Ser Val Ile Asn Gln 
65                  70                  75                  80  


Val Lys Ser Thr Ser Gly Ser Leu Phe Asn Pro Ala Asn Leu Ile Ser 
                85                  90                  95      


Arg Thr Glu Gly Ala Gly Gly Asn Phe Ala Val Gly Tyr Leu Gly Ala 
            100                 105                 110         


Gly Arg Glu Val Leu Pro Glu Val Met Ser Arg Leu Asp Phe Glu Ile 
        115                 120                 125             


Asp Lys Cys Asp Asn Val Gly Gly Ile Ile Val Leu His Ala Ile Gly 
    130                 135                 140                 


Gly Gly Ser Gly Ser Gly Leu Gly Cys Leu Leu Ile Glu Ser Leu Lys 
145                 150                 155                 160 


Glu Lys Tyr Pro Glu Tyr Pro Val Leu Ser Cys Ala Val Leu Pro Ser 
                165                 170                 175     


Pro Gln Val Ser Ser Val Val Thr Glu Pro Tyr Asn Thr Val Phe Ala 
            180                 185                 190         


Leu Asn Thr Leu Arg Arg Ala Ala Asp Ala Cys Leu Ile Phe Asp Asn 
        195                 200                 205             


Glu Ala Leu Phe Asp Leu Ala His Arg Lys Trp Asn Ile Glu Ser Pro 
    210                 215                 220                 


Thr Val Asp Asp Leu Asn Leu Leu Ile Thr Glu Ala Leu Ala Gly Ile 
225                 230                 235                 240 


Thr Ala Ser Met Arg Phe Ser Gly Phe Leu Thr Val Glu Ile Ser Leu 
                245                 250                 255     


Arg Glu Leu Leu Thr Asn Leu Val Pro Gln Pro Ser Leu His Phe Leu 
            260                 265                 270         


Met Cys Ala Phe Ala Pro Leu Thr Ala Pro Asp Arg Ser Lys Phe Glu 
        275                 280                 285             


Glu Met Gly Ile Glu Asp Met Ile Arg Ser Leu Phe Asp Asn Asp Ser 
    290                 295                 300                 


Val Tyr Ala Ala Cys Ser Pro Met Glu Gly Arg Phe Leu Ser Thr Ala 
305                 310                 315                 320 


Val Leu Tyr Arg Gly Ile Met Glu Asp Lys Pro Leu Ala Asp Ala Ala 
                325                 330                 335     


Leu Ala Ala Met Arg Glu Lys Leu Pro Leu Thr Tyr Trp Ile Pro Thr 
            340                 345                 350         


Ala Phe Lys Ile Gly Tyr Val Glu Gln Ser Gly Ile Ser His Arg Lys 
        355                 360                 365             


Ser Met Val Leu Leu Ala Asn Asn Thr Glu Ile Ala Arg Val Leu Asp 
    370                 375                 380                 


Arg Ile Cys His Asn Phe Asp Lys Leu Trp Gln Arg Lys Ala Phe Ala 
385                 390                 395                 400 


Asn Trp Tyr Leu Asn Glu Gly Met Ser Glu Glu Gln Ile Asn Gly Leu 
                405                 410                 415     


Arg Ala Ser Ala Gln Glu Leu Ile Gln Ser Tyr Gln Val Ala Glu Glu 
            420                 425                 430         


Ser Gly Ala Lys Ala Lys Ile Gln Asp Val Ser Gly Glu Thr Val Ser 
        435                 440                 445             


Arg Ser Ser Ser Met Asp Asp Pro Arg Ser Thr Met Ser Leu Arg Asp 
    450                 455                 460                 


Leu Val Glu Arg Arg Arg 
465                 470 


<210>  6
<211>  426
<212>  PRT
<213>  Prosthecobacter debontii


<220>
<221>  misc_feature
<222>  (214)..(214)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Met Arg Glu Ile Leu Ser Ile His Val Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Ala Asp Ser Phe Trp Arg Leu Ala Leu Lys Glu His Gly Leu Thr Glu 
            20                  25                  30          


Thr Gly Thr Leu Lys Glu Gly Ala Asn Ala Ala Ala Asn Ser Asp Leu 
        35                  40                  45              


Glu Val Phe Phe His Arg Val Arg Glu Gly Lys Tyr Val Pro Arg Ala 
    50                  55                  60                  


Val Leu Ile Asp Leu Glu Pro Gly Val Ile Gly Arg Ile Glu Ser Gly 
65                  70                  75                  80  


Asp Met Ser Lys Leu Phe Asp Glu Ser Cys Ile Val Arg Lys Ile Pro 
                85                  90                  95      


Gly Ala Ala Asn Asn Trp Ala Arg Gly Tyr His Ala Glu Gly Lys Arg 
            100                 105                 110         


Val Ile Asp Gln Ile Met Asn Val Ile Asp Ser Ala Val Glu Lys Thr 
        115                 120                 125             


Lys Gly Leu Gln Gly Phe Leu Leu Thr His Ser Ile Gly Gly Gly Ser 
    130                 135                 140                 


Gly Ser Gly Leu Gly Ser Leu Ile Leu Glu Arg Leu Arg Gln Ala Tyr 
145                 150                 155                 160 


Pro Lys Lys Arg Ile Phe Thr Phe Ser Val Val Pro Ser Pro Leu Ile 
                165                 170                 175     


Ser Asp Ser Ala Val Glu Pro Tyr Asn Ala Ile Leu Thr Leu Lys Arg 
            180                 185                 190         


Leu Leu Asp His Ala Asp Gly Ser Val Leu Leu Asp Asn Glu Ala Leu 
        195                 200                 205             


Phe Arg Ile Ala Lys Xaa Lys Leu Asn Arg Ser Pro Thr Tyr Met Asp 
    210                 215                 220                 


Leu Asn Asn Ile Ile Ala Leu Ile Val Ser Ser Val Thr Ala Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Lys Leu Asn Thr Asp Leu Ser Glu Phe Val Thr Asn 
                245                 250                 255     


Leu Val Pro Phe Pro Gly Asn His Phe Leu Thr Ala Ser Phe Ala Pro 
            260                 265                 270         


Met Arg Thr Ala Asp Asp Glu Ser Gln Val Arg Met Ser Phe Pro Glu 
        275                 280                 285             


Leu Ala Arg Glu Thr Phe Ala Gln Asp Asn Phe Thr Ala Glu Ile Asp 
    290                 295                 300                 


Trp Gln Asn Gly Val Tyr Leu Ala Ala Ser Ala Leu Phe Arg Gly Glu 
305                 310                 315                 320 


Val Lys Ala Lys Glu Val Asp Glu Asn Met Ala Thr Ile Arg Lys Glu 
                325                 330                 335     


Leu Asn Tyr Ala Ser Tyr Met Pro Ala Ser Gly Gly Leu Lys Leu Gly 
            340                 345                 350         


Tyr Ala Glu Thr Ala Pro Ala Gly Phe Ala Ser Ser Gly Leu Ala Leu 
        355                 360                 365             


Val Asn His Thr Gly Ile Ser Ala Val Phe Glu Arg Leu Ile Gly Gln 
    370                 375                 380                 


Phe Asp Ile Met Phe Asp Asn His Ala Tyr Thr His Trp Tyr Glu Asn 
385                 390                 395                 400 


Ala Gly Val Ser Arg Asp Gln Met Ala Val Ala Arg Asp Gln Ile Ala 
                405                 410                 415     


Asn Leu Ala Leu Ser Tyr Arg Asp Ala Ser 
            420                 425     


<210>  7
<211>  473
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (43)..(44)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (54)..(55)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (60)..(61)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (79)..(81)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (143)..(143)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (147)..(147)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (151)..(151)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (153)..(153)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (159)..(159)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (164)..(164)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (166)..(166)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (192)..(192)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (199)..(199)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (213)..(213)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (240)..(240)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (255)..(255)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (275)..(275)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (281)..(281)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (290)..(290)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (292)..(292)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (294)..(294)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (297)..(297)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (303)..(303)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (306)..(306)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (335)..(335)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (343)..(343)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (362)..(362)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (415)..(415)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (424)..(424)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (439)..(439)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (442)..(448)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (450)..(456)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (459)..(459)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (461)..(462)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (470)..(470)
<223>  Xaa denotes any amino acid residue

<400>  7

Met Lys Val Asn Asn Thr Ile Val Xaa Ser Ile Gly Gln Ala Gly Asn 
1               5                   10                  15      


Gln Ile Ala Ala Ser Phe Trp Lys Thr Xaa Cys Xaa Glu His Gly Ile 
            20                  25                  30          


Asp Pro Xaa Thr Gly Gln Thr Ala Xaa Gly Xaa Xaa Pro Arg Gly Asn 
        35                  40                  45              


Trp Ser Xaa Phe Phe Xaa Xaa Leu Gly Xaa Ser Xaa Xaa Gly Ser Xaa 
    50                  55                  60                  


Val Pro Arg Ala Xaa Met Val Asp Leu Glu Pro Ser Val Ile Xaa Xaa 
65                  70                  75                  80  


Xaa Lys Xaa Thr Ser Gly Ser Leu Phe Asn Pro Xaa Asn Leu Ile Ser 
                85                  90                  95      


Arg Thr Glu Gly Ala Gly Gly Asn Phe Ala Val Gly Tyr Leu Gly Ala 
            100                 105                 110         


Gly Arg Glu Val Leu Pro Glu Val Met Ser Arg Leu Asp Xaa Glu Ile 
        115                 120                 125             


Asp Lys Cys Asp Asn Val Gly Gly Ile Ile Val Leu His Ala Xaa Gly 
    130                 135                 140                 


Gly Gly Xaa Gly Ser Gly Xaa Gly Xaa Leu Leu Ile Glu Ser Xaa Lys 
145                 150                 155                 160 


Glu Lys Tyr Xaa Glu Xaa Pro Val Leu Ser Cys Ala Val Leu Pro Ser 
                165                 170                 175     


Pro Gln Val Ser Ser Val Val Thr Glu Pro Tyr Asn Thr Val Phe Xaa 
            180                 185                 190         


Leu Asn Thr Leu Arg Arg Xaa Ala Asp Ala Cys Leu Ile Phe Asp Asn 
        195                 200                 205             


Glu Ala Leu Phe Xaa Leu Ala His Arg Lys Trp Asn Ile Glu Ser Pro 
    210                 215                 220                 


Thr Val Asp Asp Leu Asn Leu Leu Ile Thr Glu Ala Leu Ala Gly Xaa 
225                 230                 235                 240 


Thr Ala Ser Met Arg Phe Ser Gly Phe Leu Thr Val Glu Ile Xaa Leu 
                245                 250                 255     


Arg Glu Leu Leu Thr Asn Leu Val Pro Gln Pro Ser Leu His Phe Leu 
            260                 265                 270         


Met Cys Xaa Phe Ala Pro Leu Thr Xaa Pro Asp Arg Ser Lys Phe Glu 
        275                 280                 285             


Glu Xaa Gly Xaa Glu Xaa Met Ile Xaa Ser Leu Phe Asp Asn Xaa Ser 
    290                 295                 300                 


Val Xaa Ala Ala Cys Ser Pro Met Glu Gly Arg Phe Leu Ser Thr Ala 
305                 310                 315                 320 


Val Leu Tyr Arg Gly Ile Met Glu Asp Lys Pro Leu Ala Asp Xaa Ala 
                325                 330                 335     


Leu Ala Ala Met Arg Glu Xaa Leu Pro Leu Thr Tyr Trp Ile Pro Thr 
            340                 345                 350         


Ala Phe Lys Ile Gly Tyr Val Glu Gln Xaa Gly Ile Ser His Arg Lys 
        355                 360                 365             


Ser Met Val Leu Leu Ala Asn Asn Thr Glu Ile Ala Arg Val Leu Asp 
    370                 375                 380                 


Arg Ile Cys His Asn Phe Asp Lys Leu Trp Gln Arg Lys Ala Phe Ala 
385                 390                 395                 400 


Asn Trp Tyr Leu Asn Glu Gly Met Ser Glu Glu Gln Ile Asn Xaa Leu 
                405                 410                 415     


Arg Ala Ser Ala Gln Glu Leu Xaa Gln Ser Tyr Gln Val Ala Glu Glu 
            420                 425                 430         


Ser Gly Ala Lys Ala Lys Xaa Gln Asp Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Asp Xaa Arg Xaa Xaa Met Ser 
    450                 455                 460                 


Leu Arg Asp Leu Val Xaa Arg Arg Arg 
465                 470             


<210>  8
<211>  426
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (46)..(48)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (65)..(65)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (83)..(84)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (107)..(108)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (111)..(113)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (136)..(136)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (171)..(171)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (191)..(191)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (193)..(193)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (199)..(200)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (214)..(214)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (217)..(217)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (221)..(221)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (227)..(227)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (233)..(233)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (251)..(251)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (253)..(253)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (275)..(278)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (280)..(280)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (284)..(285)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (288)..(289)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (302)..(302)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (306)..(307)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (312)..(312)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (314)..(314)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (320)..(320)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (325)..(325)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (327)..(327)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (332)..(332)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (336)..(336)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (339)..(339)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (343)..(343)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (345)..(346)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (348)..(348)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (352)..(352)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (358)..(358)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (360)..(360)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (375)..(375)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (383)..(384)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (401)..(401)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (407)..(407)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (410)..(410)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (413)..(414)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (416)..(417)
<223>  Xaa denotes any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (420)..(420)
<223>  Xaa denotes any amino acid residue

<400>  8

Xaa Arg Glu Ile Leu Ser Ile His Val Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Ala Asp Xaa Phe Trp Arg Leu Xaa Leu Xaa Glu His Gly Leu Thr Glu 
            20                  25                  30          


Xaa Gly Thr Xaa Lys Glu Gly Xaa Asn Xaa Ala Ala Asn Xaa Xaa Xaa 
        35                  40                  45              


Glu Val Phe Phe His Xaa Val Arg Xaa Gly Lys Tyr Xaa Pro Arg Ala 
    50                  55                  60                  


Xaa Leu Xaa Asp Leu Glu Pro Gly Val Ile Xaa Arg Ile Glu Xaa Gly 
65                  70                  75                  80  


Asp Met Xaa Xaa Leu Phe Asp Glu Ser Xaa Ile Xaa Arg Lys Ile Pro 
                85                  90                  95      


Gly Ala Ala Asn Asn Trp Ala Arg Gly Tyr Xaa Xaa Glu Gly Xaa Xaa 
            100                 105                 110         


Xaa Ile Asp Gln Ile Met Asn Val Ile Asp Xaa Ala Val Glu Lys Thr 
        115                 120                 125             


Lys Xaa Leu Gln Gly Phe Leu Xaa Thr His Ser Ile Gly Gly Gly Ser 
    130                 135                 140                 


Gly Ser Gly Leu Gly Ser Leu Ile Leu Glu Arg Leu Arg Gln Ala Tyr 
145                 150                 155                 160 


Pro Lys Lys Arg Ile Phe Thr Phe Ser Val Xaa Pro Ser Pro Leu Ile 
                165                 170                 175     


Ser Asp Ser Ala Val Glu Pro Tyr Asn Ala Ile Leu Thr Leu Xaa Arg 
            180                 185                 190         


Xaa Leu Asp Asn Ala Asp Xaa Xaa Val Leu Leu Asp Asn Glu Ala Leu 
        195                 200                 205             


Phe Arg Ile Ala Lys Xaa Lys Leu Xaa Arg Ser Pro Xaa Tyr Met Asp 
    210                 215                 220                 


Leu Asn Xaa Asn Ile Ile Ala Leu Xaa Ser Ser Val Thr Ala Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Lys Leu Asn Thr Asp Leu Xaa Glu Xaa Val Thr Asn 
                245                 250                 255     


Leu Val Pro Phe Pro Gly Asn His Phe Leu Thr Ala Ser Phe Ala Pro 
            260                 265                 270         


Met Arg Xaa Xaa Xaa Xaa Glu Xaa Gln Val Arg Xaa Xaa Phe Pro Xaa 
        275                 280                 285             


Xaa Ala Arg Glu Thr Phe Ala Gln Asp Asn Phe Thr Ala Xaa Ile Asp 
    290                 295                 300                 


Trp Xaa Xaa Gly Val Tyr Leu Xaa Ala Xaa Ala Leu Phe Arg Gly Xaa 
305                 310                 315                 320 


Val Lys Ala Lys Xaa Val Xaa Glu Asn Met Ala Xaa Ile Arg Lys Xaa 
                325                 330                 335     


Leu Asn Xaa Ala Ser Tyr Xaa Pro Xaa Xaa Gly Xaa Leu Lys Leu Xaa 
            340                 345                 350         


Tyr Ala Glu Thr Ala Xaa Glu Xaa Phe Ala Ser Ser Gly Leu Ala Leu 
        355                 360                 365             


Val Asn His Thr Gly Ile Xaa Ala Val Phe Glu Arg Leu Ile Xaa Xaa 
    370                 375                 380                 


Phe Asp Ile Met Phe Asp Asn His Ala Tyr Thr His Trp Tyr Glu Asn 
385                 390                 395                 400 


Xaa Gly Val Ser Arg Asp Xaa Met Ala Xaa Ala Arg Xaa Xaa Ile Xaa 
                405                 410                 415     


Xaa Leu Ala Xaa Ser Tyr Arg Asp Ala Ser 
            420                 425     


<210>  9
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly Glu Glu Tyr 
1               5                   10                  15  


<210>  10
<211>  13
<212>  PRT
<213>  Bos taurus

<400>  10

Ala Asp Ser Ala Glu Gly Asp Asp Glu Gly Asp Glu Tyr 
1               5                   10              


<210>  11
<211>  15
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Val Gly Thr Asp Ser Phe Glu Glu Glu Asn Glu Gly Glu Glu Phe 
1               5                   10                  15  


<210>  12
<211>  18
<212>  PRT
<213>  Gallus gallus

<400>  12

Ala Thr Ala Asp Glu Gln Gly Glu Phe Glu Glu Glu Gly Glu Glu Asp 
1               5                   10                  15      


Glu Ala 
        


<210>  13
<211>  18
<212>  PRT
<213>  Bos taurus

<400>  13

Ala Thr Ala Asp Glu Gln Gly Glu Phe Glu Glu Glu Glu Gly Glu Asp 
1               5                   10                  15      


Glu Ala 
        


<210>  14
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Thr Ala Glu Glu Glu Gly Glu Phe Glu Glu Glu Ala Glu Glu Glu 
1               5                   10                  15      


Val Ala 
        


<210>  15
<211>  17
<212>  PRT
<213>  Danio rerio

<400>  15

Ala Thr Ala Glu Glu Glu Gly Glu Phe Glu Glu Glu Ala Glu Asp Asp 
1               5                   10                  15      


Ala 
    


