                         SEQUENCE LISTING

<110>   Wirtz, Ralph
 
<120>  A method to assess prognosis and to predict therapeutic success 
       in cancer by determining hormone receptor expression levels

<130>  WD40385

<160>  9     

<170>  PatentIn version 3.3

<210>  1
<211>  6456
<212>  DNA
<213>  Homo sapiens ESR1-Estrogen receptor

<400>  1
gagttgtgcc tggagtgatg tttaagccaa tgtcagggca aggcaacagt ccctggccgt     60

cctccagcac ctttgtaatg catatgagct cgggagacca gtacttaaag ttggaggccc    120

gggagcccag gagctggcgg agggcgttcg tcctgggact gcacttgctc ccgtcgggtc    180

gcccggcttc accggacccg caggctcccg gggcagggcc ggggccagag ctcgcgtgtc    240

ggcgggacat gcgctgcgtc gcctctaacc tcgggctgtg ctctttttcc aggtggcccg    300

ccggtttctg agccttctgc cctgcgggga cacggtctgc accctgcccg cggccacgga    360

ccatgaccat gaccctccac accaaagcat ccgggatggc cctactgcat cagatccaag    420

ggaacgagct ggagcccctg aaccgtccgc agctcaagat ccccctggag cggcccctgg    480

gcgaggtgta cctggacagc agcaagcccg ccgtgtacaa ctaccccgag ggcgccgcct    540

acgagttcaa cgccgcggcc gccgccaacg cgcaggtcta cggtcagacc ggcctcccct    600

acggccccgg gtctgaggct gcggcgttcg gctccaacgg cctggggggt ttccccccac    660

tcaacagcgt gtctccgagc ccgctgatgc tactgcaccc gccgccgcag ctgtcgcctt    720

tcctgcagcc ccacggccag caggtgccct actacctgga gaacgagccc agcggctaca    780

cggtgcgcga ggccggcccg ccggcattct acaggccaaa ttcagataat cgacgccagg    840

gtggcagaga aagattggcc agtaccaatg acaagggaag tatggctatg gaatctgcca    900

aggagactcg ctactgtgca gtgtgcaatg actatgcttc aggctaccat tatggagtct    960

ggtcctgtga gggctgcaag gccttcttca agagaagtat tcaaggacat aacgactata   1020

tgtgtccagc caccaaccag tgcaccattg ataaaaacag gaggaagagc tgccaggcct   1080

gccggctccg caaatgctac gaagtgggaa tgatgaaagg tgggatacga aaagaccgaa   1140

gaggagggag aatgttgaaa cacaagcgcc agagagatga tggggagggc aggggtgaag   1200

tggggtctgc tggagacatg agagctgcca acctttggcc aagcccgctc atgatcaaac   1260

gctctaagaa gaacagcctg gccttgtccc tgacggccga ccagatggtc agtgccttgt   1320

tggatgctga gccccccata ctctattccg agtatgatcc taccagaccc ttcagtgaag   1380

cttcgatgat gggcttactg accaacctgg cagacaggga gctggttcac atgatcaact   1440

gggcgaagag ggtgccaggc tttgtggatt tgaccctcca tgatcaggtc caccttctag   1500

aatgtgcctg gctagagatc ctgatgattg gtctcgtctg gcgctccatg gagcacccag   1560

ggaagctact gtttgctcct aacttgctct tggacaggaa ccagggaaaa tgtgtagagg   1620

gcatggtgga gatcttcgac atgctgctgg ctacatcatc tcggttccgc atgatgaatc   1680

tgcagggaga ggagtttgtg tgcctcaaat ctattatttt gcttaattct ggagtgtaca   1740

catttctgtc cagcaccctg aagtctctgg aagagaagga ccatatccac cgagtcctgg   1800

acaagatcac agacactttg atccacctga tggccaaggc aggcctgacc ctgcagcagc   1860

agcaccagcg gctggcccag ctcctcctca tcctctccca catcaggcac atgagtaaca   1920

aaggcatgga gcatctgtac agcatgaagt gcaagaacgt ggtgcccctc tatgacctgc   1980

tgctggagat gctggacgcc caccgcctac atgcgcccac tagccgtgga ggggcatccg   2040

tggaggagac ggaccaaagc cacttggcca ctgcgggctc tacttcatcg cattccttgc   2100

aaaagtatta catcacgggg gaggcagagg gtttccctgc cacggtctga gagctccctg   2160

gctcccacac ggttcagata atccctgctg cattttaccc tcatcatgca ccactttagc   2220

caaattctgt ctcctgcata cactccggca tgcatccaac accaatggct ttctagatga   2280

gtggccattc atttgcttgc tcagttctta gtggcacatc ttctgtcttc tgttgggaac   2340

agccaaaggg attccaaggc taaatctttg taacagctct ctttccccct tgctatgtta   2400

ctaagcgtga ggattcccgt agctcttcac agctgaactc agtctatggg ttggggctca   2460

gataactctg tgcatttaag ctacttgtag agacccaggc ctggagagta gacattttgc   2520

ctctgataag cactttttaa atggctctaa gaataagcca cagcaaagaa tttaaagtgg   2580

ctcctttaat tggtgacttg gagaaagcta ggtcaagggt ttattatagc accctcttgt   2640

attcctatgg caatgcatcc ttttatgaaa gtggtacacc ttaaagcttt tatatgactg   2700

tagcagagta tctggtgatt gtcaattcat tccccctata ggaatacaag gggcacacag   2760

ggaaggcaga tcccctagtt ggcaagacta ttttaacttg atacactgca gattcagatg   2820

tgctgaaagc tctgcctctg gctttccggt catgggttcc agttaattca tgcctcccat   2880

ggacctatgg agagcagcaa gttgatctta gttaagtctc cctatatgag ggataagttc   2940

ctgatttttg tttttatttt tgtgttacaa aagaaagccc tccctccctg aacttgcagt   3000

aaggtcagct tcaggacctg ttccagtggg cactgtactt ggatcttccc ggcgtgtgtg   3060

tgccttacac aggggtgaac tgttcactgt ggtgatgcat gatgagggta aatggtagtt   3120

gaaaggagca ggggccctgg tgttgcattt agccctgggg catggagctg aacagtactt   3180

gtgcaggatt gttgtggcta ctagagaaca agagggaaag tagggcagaa actggataca   3240

gttctgaggc acagccagac ttgctcaggg tggccctgcc acaggctgca gctacctagg   3300

aacattcctt gcagaccccg cattgccctt tgggggtgcc ctgggatccc tggggtagtc   3360

cagctcttct tcatttccca gcgtggccct ggttggaaga agcagctgtc acagctgctg   3420

tagacagctg tgttcctaca attggcccag caccctgggg cacgggagaa gggtggggac   3480

cgttgctgtc actactcagg ctgactgggg cctggtcaga ttacgtatgc ccttggtggt   3540

ttagagataa tccaaaatca gggtttggtt tggggaagaa aatcctcccc cttcctcccc   3600

cgccccgttc cctaccgcct ccactcctgc cagctcattt ccttcaattt cctttgaacc   3660

tataggctaa aaaagaaagg ctcattccag ccacagggca gccttccctg ggcctttgct   3720

tctctagcac aattatgggt tacttccttt ttcttaacaa aaaagaatgt ttgatttcct   3780

ctgggtgacc ttattgtctg taattgaaac cctattgaga ggtgatgtct gtgttagcca   3840

atgacccagg tgagctgctc gggcttctct tggtatgtct tgtttggaaa agtggatttc   3900

attcatttct gattgtccag ttaagtgatc accaaaggac tgagaatctg ggagggcaaa   3960

aaaaaaaaaa aagtttttat gtgcacttaa atttggggac aattttatgt atctgtgtta   4020

aggatatgtt taagaacata attcttttgt tgctgtttgt ttaagaagca ccttagtttg   4080

tttaagaagc accttatata gtataatata tatttttttg aaattacatt gcttgtttat   4140

cagacaattg aatgtagtaa ttctgttctg gatttaattt gactgggtta acatgcaaaa   4200

accaaggaaa aatatttagt tttttttttt ttttttgtat acttttcaag ctaccttgtc   4260

atgtatacag tcatttatgc ctaaagcctg gtgattattc atttaaatga agatcacatt   4320

tcatatcaac ttttgtatcc acagtagaca aaatagcact aatccagatg cctattgttg   4380

gatattgaat gacagacaat cttatgtagc aaagattatg cctgaaaagg aaaattattc   4440

agggcagcta attttgcttt taccaaaata tcagtagtaa tatttttgga cagtagctaa   4500

tgggtcagtg ggttcttttt aatgtttata cttagatttt cttttaaaaa aattaaaata   4560

aaacaaaaaa aaatttctag gactagacga tgtaatacca gctaaagcca aacaattata   4620

cagtggaagg ttttacatta ttcatccaat gtgtttctat tcatgttaag atactactac   4680

atttgaagtg ggcagagaac atcagatgat tgaaatgttc gcccaggggt ctccagcaac   4740

tttggaaatc tctttgtatt tttacttgaa gtgccactaa tggacagcag atattttctg   4800

gctgatgttg gtattgggtg taggaacatg atttaaaaaa aaactcttgc ctctgctttc   4860

ccccactctg aggcaagtta aaatgtaaaa gatgtgattt atctgggggg ctcaggtatg   4920

gtggggaagt ggattcagga atctggggaa tggcaaatat attaagaaga gtattgaaag   4980

tatttggagg aaaatggtta attctgggtg tgcaccaggg ttcagtagag tccacttctg   5040

ccctggagac cacaaatcaa ctagctccat ttacagccat ttctaaaatg gcagcttcag   5100

ttctagagaa gaaagaacaa catcagcagt aaagtccatg gaatagctag tggtctgtgt   5160

ttcttttcgc cattgcctag cttgccgtaa tgattctata atgccatcat gcagcaatta   5220

tgagaggcta ggtcatccaa agagaagacc ctatcaatgt aggttgcaaa atctaacccc   5280

taaggaagtg cagtctttga tttgatttcc ctagtaacct tgcagatatg tttaaccaag   5340

ccatagccca tgccttttga gggctgaaca aataagggac ttactgataa tttacttttg   5400

atcacattaa ggtgttctca ccttgaaatc ttatacactg aaatggccat tgatttaggc   5460

cactggctta gagtactcct tcccctgcat gacactgatt acaaatactt tcctattcat   5520

actttccaat tatgagatgg actgtgggta ctgggagtga tcactaacac catagtaatg   5580

tctaatattc acaggcagat ctgcttgggg aagctagtta tgtgaaaggc aaatagagtc   5640

atacagtagc tcaaaaggca accataattc tctttggtgc aggtcttggg agcgtgatct   5700

agattacact gcaccattcc caagttaatc ccctgaaaac ttactctcaa ctggagcaaa   5760

tgaactttgg tcccaaatat ccatcttttc agtagcgtta attatgctct gtttccaact   5820

gcatttcctt tccaattgaa ttaaagtgtg gcctcgtttt tagtcattta aaattgtttt   5880

ctaagtaatt gctgcctcta ttatggcact tcaattttgc actgtctttt gagattcaag   5940

aaaaatttct attctttttt ttgcatccaa ttgtgcctga acttttaaaa tatgtaaatg   6000

ctgccatgtt ccaaacccat cgtcagtgtg tgtgtttaga gctgtgcacc ctagaaacaa   6060

catattgtcc catgagcagg tgcctgagac acagacccct ttgcattcac agagaggtca   6120

ttggttatag agacttgaat taataagtga cattatgcca gtttctgttc tctcacaggt   6180

gataaacaat gctttttgtg cactacatac tcttcagtgt agagctcttg ttttatggga   6240

aaaggctcaa atgccaaatt gtgtttgatg gattaatatg cccttttgcc gatgcatact   6300

attactgatg tgactcggtt ttgtcgcagc tttgctttgt ttaatgaaac acacttgtaa   6360

acctcttttg cactttgaaa aagaatccag cgggatgctc gagcacctgt aaacaatttt   6420

ctcaacctat ttgatgttca aataaagaat taaact                             6456


<210>  2
<211>  2745
<212>  DNA
<213>  Homo sapiens ESR2 - Estrogen receptor

<400>  2
gtgtgagggc gcccggcttc caggcagtaa tgggcgggtc cctgcgcggg agcgtggcgg     60

gcgctggact ctacagcaga tgtggaactg gagagcttgg cgcgccttcc gactttgtca    120

cacacctgcg ccgccagact ggggtcgggc ccctccgcgt tctgctctgg agtgcctggg    180

tctgggccca gcaccgcgct tttagaatct cctcagctga atctgacgct cagcagtggg    240

tgaagcgcag ccccctgttt caggccctgc cgagctggaa ggagtgtcag agctggagcg    300

cgcgtggccc cctctgtgtt ggggtcaccc cggggttgcc agggctcagg gagggtcgta    360

gtctggattt tgtcacccgc acgtccccac cccccagcag gtctggggtt ggagaatcca    420

cgcgggcttc ataagctaga tgccagttaa ctgtcgagag gggacgctcc ctcctcgtag    480

gcgtccacac tggagaagga ataagatggg cgattgcctg ggaagcctga cagggcggcg    540

gcagctggga tgctggagag gactggcccc ttgagttact gagtccgatg aatgtgcttg    600

ctctgctgga ggaaccgcgc tcaggttaca gtcatcccaa tatggttctg aagccattat    660

acttgcccac gaatctttga gaacattata atgacctttg tgcctcttct tgcaaggtgt    720

tttctcagct gttatctcaa gacatggata taaaaaactc accatctagc cttaattctc    780

cttcctccta caactgcagt caatccatct tacccctgga gcacggctcc atatacatac    840

cttcctccta tgtagacagc caccatgaat atccagccat gacattctat agccctgctg    900

tgatgaatta cagcattccc agcaatgtca ctaacttgga aggtgggcct ggtcggcaga    960

ccacaagccc aaatgtgttg tggccaacac ctgggcacct ttctccttta gtggtccatc   1020

gccagttatc acatctgtat gcggaacctc aaaagagtcc ctggtgtgaa gcaagatcgc   1080

tagaacacac cttacctgta aacagagaga cactgaaaag gaaggttagt gggaaccgtt   1140

gcgccagccc tgttactggt ccaggttcaa agagggatgc tcacttctgc gctgtctgca   1200

gcgattacgc atcgggatat cactatggag tctggtcgtg tgaaggatgt aaggcctttt   1260

ttaaaagaag cattcaagga cataatgatt atatttgtcc agctacaaat cagtgtacaa   1320

tcgataaaaa ccggcgcaag agctgccagg cctgccgact tcggaagtgt tacgaagtgg   1380

gaatggtgaa gtgtggctcc cggagagaga gatgtgggta ccgccttgtg cggagacaga   1440

gaagtgccga cgagcagctg cactgtgccg gcaaggccaa gagaagtggc ggccacgcgc   1500

cccgagtgcg ggagctgctg ctggacgccc tgagccccga gcagctagtg ctcaccctcc   1560

tggaggctga gccgccccat gtgctgatca gccgccccag tgcgcccttc accgaggcct   1620

ccatgatgat gtccctgacc aagttggccg acaaggagtt ggtacacatg atcagctggg   1680

ccaagaagat tcccggcttt gtggagctca gcctgttcga ccaagtgcgg ctcttggaga   1740

gctgttggat ggaggtgtta atgatggggc tgatgtggcg ctcaattgac caccccggca   1800

agctcatctt tgctccagat cttgttctgg acagggatga ggggaaatgc gtagaaggaa   1860

ttctggaaat ctttgacatg ctcctggcaa ctacttcaag gtttcgagag ttaaaactcc   1920

aacacaaaga atatctctgt gtcaaggcca tgatcctgct caattccagt atgtaccctc   1980

tggtcacagc gacccaggat gctgacagca gccggaagct ggctcacttg ctgaacgccg   2040

tgaccgatgc tttggtttgg gtgattgcca agagcggcat ctcctcccag cagcaatcca   2100

tgcgcctggc taacctcctg atgctcctgt cccacgtcag gcatgcgagg gcagaaaagg   2160

cctctcaaac actcacctca tttggaatga agatggagac tcttttgcct gaagcaacga   2220

tggagcagtg accctctaat caactcggtg gcctaaagaa aaatcttggg taacattttc   2280

acttcagttt ccctctggga tcattgtaat ccatgaaaaa aataatttta aagaaagagt   2340

taaaatactt tgaagttagt tatgtggtta aaaaccacct tcctttctat tatcaatcca   2400

acaatttgat aactgtaaac gctaaagtga agacggattc tcttcagatg gtctccttaa   2460

ctgcccaggg cttgcagatg tctcacccat gaggggcacc aatgtagaaa gctgaggctt   2520

catctactga tgagcttcac tggtttcccc tgaggtttgt gctttggcag agaaggggag   2580

gaggggactg ggattgtgtg gtcagctgtg cctgccaaca gatgcaggtt aggaactgtg   2640

ttcagtatct tccaataaga aaggggaaat gccgatgcct atcctctttg tttaggtaga   2700

aagtaaaatg ctactggact taaatgggca aaaaaaaaaa aaaaa                   2745


<210>  3
<211>  13037
<212>  DNA
<213>  Homo sapiens -PGR - Progesterone receptor

<400>  3
agtccacagc tgtcactaat cggggtaagc cttgttgtat ttgtgcgtgt gggtggcatt     60

ctcaatgaga actagcttca cttgtcattt gagtgaaatc tacaacccga ggcggctagt    120

gctcccgcac tactgggatc tgagatcttc ggagatgact gtcgcccgca gtacggagcc    180

agcagaagtc cgacccttcc tgggaatggg ctgtaccgag aggtccgact agccccaggg    240

ttttagtgag ggggcagtgg aactcagcga gggactgaga gcttcacagc atgcacgagt    300

ttgatgccag agaaaaagtc gggagataaa ggagccgcgt gtcactaaat tgccgtcgca    360

gccgcagcca ctcaagtgcc ggacttgtga gtactctgcg tctccagtcc tcggacagaa    420

gttggagaac tctcttggag aactccccga gttaggagac gagatctcct aacaattact    480

actttttctt gcgctcccca cttgccgctc gctgggacaa acgacagcca cagttcccct    540

gacgacagga tggaggccaa gggcaggagc tgaccagcgc cgccctcccc cgcccccgac    600

ccaggaggtg gagatccctc cggtccagcc acattcaaca cccactttct cctccctctg    660

cccctatatt cccgaaaccc cctcctcctt cccttttccc tcctcctgga gacgggggag    720

gagaaaaggg gagtccagtc gtcatgactg agctgaaggc aaagggtccc cgggctcccc    780

acgtggcggg cggcccgccc tcccccgagg tcggatcccc actgctgtgt cgcccagccg    840

caggtccgtt cccggggagc cagacctcgg acaccttgcc tgaagtttcg gccataccta    900

tctccctgga cgggctactc ttccctcggc cctgccaggg acaggacccc tccgacgaaa    960

agacgcagga ccagcagtcg ctgtcggacg tggagggcgc atattccaga gctgaagcta   1020

caaggggtgc tggaggcagc agttctagtc ccccagaaaa ggacagcgga ctgctggaca   1080

gtgtcttgga cactctgttg gcgccctcag gtcccgggca gagccaaccc agccctcccg   1140

cctgcgaggt caccagctct tggtgcctgt ttggccccga acttcccgaa gatccaccgg   1200

ctgcccccgc cacccagcgg gtgttgtccc cgctcatgag ccggtccggg tgcaaggttg   1260

gagacagctc cgggacggca gctgcccata aagtgctgcc ccggggcctg tcaccagccc   1320

ggcagctgct gctcccggcc tctgagagcc ctcactggtc cggggcccca gtgaagccgt   1380

ctccgcaggc cgctgcggtg gaggttgagg aggaggatgg ctctgagtcc gaggagtctg   1440

cgggtccgct tctgaagggc aaacctcggg ctctgggtgg cgcggcggct ggaggaggag   1500

ccgcggctgt cccgccgggg gcggcagcag gaggcgtcgc cctggtcccc aaggaagatt   1560

cccgcttctc agcgcccagg gtcgccctgg tggagcagga cgcgccgatg gcgcccgggc   1620

gctccccgct ggccaccacg gtgatggatt tcatccacgt gcctatcctg cctctcaatc   1680

acgccttatt ggcagcccgc actcggcagc tgctggaaga cgaaagttac gacggcgggg   1740

ccggggctgc cagcgccttt gccccgccgc ggagttcacc ctgtgcctcg tccaccccgg   1800

tcgctgtagg cgacttcccc gactgcgcgt acccgcccga cgccgagccc aaggacgacg   1860

cgtaccctct ctatagcgac ttccagccgc ccgctctaaa gataaaggag gaggaggaag   1920

gcgcggaggc ctccgcgcgc tccccgcgtt cctaccttgt ggccggtgcc aaccccgcag   1980

ccttcccgga tttcccgttg gggccaccgc ccccgctgcc gccgcgagcg accccatcca   2040

gacccgggga agcggcggtg acggccgcac ccgccagtgc ctcagtctcg tctgcgtcct   2100

cctcggggtc gaccctggag tgcatcctgt acaaagcgga gggcgcgccg ccccagcagg   2160

gcccgttcgc gccgccgccc tgcaaggcgc cgggcgcgag cggctgcctg ctcccgcggg   2220

acggcctgcc ctccacctcc gcctctgccg ccgccgccgg ggcggccccc gcgctctacc   2280

ctgcactcgg cctcaacggg ctcccgcagc tcggctacca ggccgccgtg ctcaaggagg   2340

gcctgccgca ggtctacccg ccctatctca actacctgag gccggattca gaagccagcc   2400

agagcccaca atacagcttc gagtcattac ctcagaagat ttgtttaatc tgtggggatg   2460

aagcatcagg ctgtcattat ggtgtcctta cctgtgggag ctgtaaggtc ttctttaaga   2520

gggcaatgga agggcagcac aactacttat gtgctggaag aaatgactgc atcgttgata   2580

aaatccgcag aaaaaactgc ccagcatgtc gccttagaaa gtgctgtcag gctggcatgg   2640

tccttggagg tcgaaaattt aaaaagttca ataaagtcag agttgtgaga gcactggatg   2700

ctgttgctct cccacagcca gtgggcgttc caaatgaaag ccaagcccta agccagagat   2760

tcactttttc accaggtcaa gacatacagt tgattccacc actgatcaac ctgttaatga   2820

gcattgaacc agatgtgatc tatgcaggac atgacaacac aaaacctgac acctccagtt   2880

ctttgctgac aagtcttaat caactaggcg agaggcaact tctttcagta gtcaagtggt   2940

ctaaatcatt gccaggtttt cgaaacttac atattgatga ccagataact ctcattcagt   3000

attcttggat gagcttaatg gtgtttggtc taggatggag atcctacaaa cacgtcagtg   3060

ggcagatgct gtattttgca cctgatctaa tactaaatga acagcggatg aaagaatcat   3120

cattctattc attatgcctt accatgtggc agatcccaca ggagtttgtc aagcttcaag   3180

ttagccaaga agagttcctc tgtatgaaag tattgttact tcttaataca attcctttgg   3240

aagggctacg aagtcaaacc cagtttgagg agatgaggtc aagctacatt agagagctca   3300

tcaaggcaat tggtttgagg caaaaaggag ttgtgtcgag ctcacagcgt ttctatcaac   3360

ttacaaaact tcttgataac ttgcatgatc ttgtcaaaca acttcatctg tactgcttga   3420

atacatttat ccagtcccgg gcactgagtg ttgaatttcc agaaatgatg tctgaagtta   3480

ttgctgcaca attacccaag atattggcag ggatggtgaa accccttctc tttcataaaa   3540

agtgaatgtc atctttttct tttaaagaat taaattttgt ggtatgtctt tttgttttgg   3600

tcaggattat gaggtcttga gtttttataa tgttcttctg aaagccttac atttataaca   3660

tcatagtgtg taaatttaaa agaaaaattg tgaggttcta attattttct tttataaagt   3720

ataattagaa tgtttaactg ttttgtttac ccatattttc ttgaagaatt tacaagattg   3780

aaaaagtact aaaattgtta aagtaaacta tcttatccat attatttcat accatgtagg   3840

tgaggatttt taacttttgc atctaacaaa tcatcgactt aagagaaaaa atcttacatg   3900

taataacaca aagctattat atgttatttc taggtaactc cctttgtgtc aattatattt   3960

ccaaaaatga acctttaaaa tggtatgcaa aattttgtct atatatattt gtgtgaggag   4020

gaaattcata actttcctca gattttcaaa agtattttta atgcaaaaaa tgtagaaaga   4080

gtttaaaacc actaaaatag attgatgttc ttcaaactag gcaaaacaac tcatatgtta   4140

agaccatttt ccagattgga aacacaaatc tcttaggaag ttaataagta gattcatatc   4200

attatgcaaa tagtattgtg ggttttgtag gtttttaaaa taaccttttt tggggagaga   4260

attgtcctct aatgaggtat tgcgagtgga cataagaaat cagaagatta tggcctaact   4320

gtactcctta ccaactgtgg catgctgaaa gttagtcact cttactgatt ctcaattctc   4380

tcacctttga aagtagtaaa atatctttcc tgccaattgc tcctttgggt cagagcttat   4440

taacatcttt tcaaatcaaa ggaaagaaga aagggagagg aggaggaggg aggtatcaat   4500

tcacatacct ttctcctctt tatcctccac tatcatgaat tcatattatg tttcagccat   4560

gcaaatcttt ttaccatgaa atttcttcca gaattttccc cctttgacac aaattccatg   4620

catgtttcaa ccttcgagac tcagccaaat gtcatttctg taaaatcttc cctgagtctt   4680

ccaagcagta atttgccttc tcctagagtt tacctgccat tttgtgcaca tttgagttac   4740

agtagcatgt tattttacaa ttgtgactct cctgggagtc tgggagccat ataaagtggt   4800

caatagtgtt tgctgactga gagttgaatg acattttctc tctgtcttgg tattactgta   4860

gatttcgatc attctttggt tacatttctg catatttctg tacccatgac tttatcactt   4920

tcttctccca tgctttatct ccatcaatta tcttcattac ttttaaattt tccacctttg   4980

cttcctactt tgtgagatct ctccctttac tgactataac atagaagaat agaagtgtat   5040

tttatgtgtc ttaaggacaa tactttagat tccttgttct aagtttttaa actgaatgaa   5100

tggaatatta tttctctccc taagcaaaat tccacaaaac aattatttct tatgtttatg   5160

tagccttaaa ttgttttgta ctgtaaacct cagcataaaa actttcttca tttctaattt   5220

cattcaacaa atattgattg aatacctggt attagcacaa gaaaaatgtg ctaataagcc   5280

ttatgagaat ttggagctga agaaagacat ataactcagg aaagttacag tccagtagta   5340

ggtataaatt acagtgcctg ataaataggc attttaatat ttgtacactc aacgtatact   5400

aggtaggtgc aaaacattta catataattt tactgatacc catgcagcac aaaggtacta   5460

actttaaata ttaaataaca cctttatgtg tcagtaattc atttgcatta aatcttattg   5520

aaaaggcttt caatatattt tccccacaaa tgtcatccca agaaaaaagt atttttaaca   5580

tctcccaaat ataatagtta caggaaatct acctctgtga gagtgacacc tctcagaatg   5640

aactgtgtga cacaagaaaa tgaatgtagg tctatccaaa aaaaacccca agaaacaaaa   5700

acaatattat tagcccttta tgcttaagtg atggactcag ggaacagttg atgttgtgat   5760

cattttatta tctgattctt gttactttga attaaaccaa tattttgatg atataaatca   5820

tttccaccag catatattta atttccataa taactttaaa attttctaat ttcactcaac   5880

tatgagggaa tagaatgtgg tggccacagg tttggctttt gttaaaatgt ttgatatctt   5940

cgatgttgat ctctgtctgc aatgtagatg tctaaacact aggatttaat atttaaggct   6000

aagctttaaa aataaagtac ctttttaaaa agaatatggc ttcaccaaat ggaaaatacc   6060

taatttctaa atctttttct ctacaaagtc ctatctacta atgtctccat tactatttag   6120

tcatcataac cattatcttc attttacatg tcgtgttctt tctggtagct ctaaaatgac   6180

actaaatcat aagaagacag gttacatatc aggaaatact tgaaggttac tgaaatagat   6240

tcttgagtta atgaaaatat tttctgtaaa aaggtttgaa aagccatttg agtctaaagc   6300

attatacctc cattatcagt agttatgtga caattgtgtg tgtgtttaat gtttaaagat   6360

gtggcacttt ttaataaggc aatgctatgc tattttttcc catttaacat taagataatt   6420

tattgctata cagatgatat ggaaatatga tgaacaatat tttttttgcc aaaactatgc   6480

cttgtaagta gccatggaat gtcaacctgt aacttaaatt atccacagat agtcatgtgt   6540

ttgatgatgg gcactgtgga gataactgac ataggactgt gccccccttc tctgccactt   6600

actagctgga tgagattaag caagtcattt aactgctctg attaaacctg cctttcccaa   6660

gtgctttgta atgaatagaa atggaaacca aaaaaaacgt atacaggcct tcagaaatag   6720

taattgctac tattttgttt tcattaagcc atagttctgg ctataatttt atcaaactca   6780

ccagctatat tctacagtga aagcaggatt ctagaaagtc tcactgtttt atttatgtca   6840

ccatgtgcta tgatatattt ggttgaattc atttgaaatt agggctggaa gtattcaagt   6900

aatttcttct gctgaaaaaa tacagtgttt tgagtttagg gcctgtttta tcaaagttct   6960

aaagagccta tcactcttcc attgtagaca ttttaaaata atgacactga ttttaacatt   7020

tttaagtgtc tttttagaac agagagcctg actagaacac agcccctcca aaaacccatg   7080

ctcaaattat ttttactatg gcagcaattc cacaaaaggg aacaatgggt ttagaaatta   7140

caatgaagtc atcaacccaa aaaacatccc tatccctaag aaggttatga tataaaatgc   7200

ccacaagaaa tctatgtctg ctttaatctg tcttttattg ctttggaagg atggctatta   7260

catttttagt ttttgctgtg aatacctgag cagtttctct catccatact tatccttcac   7320

acatcagaag tcaggataga atatgaatca ttttaaaaac ttttacaact ccagagccat   7380

gtgcataaga agcattcaaa acttgccaaa acatacattt tttttcaaat ttaaagatac   7440

tctatttttg tattcaatag ctcaacaact gtggtcccca ctgataaagt gaagtggaca   7500

aggagacaag taatggcata agtttgtttt tcccaaagta tgcctgttca atagccattg   7560

gatgtgggaa atttctacat ctcttaaaat tttacagaaa atacatagcc agatagtcta   7620

gcaaaagttc accaagtcct aaattgctta tccttacttc actaagtcat gaaatcattt   7680

taatgaaaag aacatcacct aggttttgtg gtttcttttt ttcttattca tggctgagtg   7740

aaaacaacaa tctctgtttc tccctagcat ctgtggacta tttaatgtac cattattcca   7800

cactctatgg tccttactaa atacaaaatt gaacaaaaag cagtaaaaca actgactctt   7860

cacccatatt ataaaatata atccaagcca gattagtcaa catccataag atgaatccaa   7920

gctgaactgg gcctagatta ttgagttcag gttggatcac atccctattt attaataaac   7980

ttaggaaaga aggccttaca gaccatcagt tagctggagc taatagaacc tacacttcta   8040

aagttcggcc tagaatcaat gtggccttaa aagctgaaaa gaagcaggaa agaacagttt   8100

tcttcaataa tttgtccacc ctgtcactgg agaaaattta agaatttggg ggtgttggta   8160

gtaagttaaa cacagcagct gttcatggca gaaattattc aatacatacc ttctctgaat   8220

atcctataac caaagcaaag aaaaacacca aggggtttgt tctcctcctt ggagttgacc   8280

tcattccaag gcagagctca ggtcacaggc acaggggctg cgcccaagct tgtccgcagc   8340

cttatgcagc tgtggagtct ggaagactgt tgcaggactg ctggcctagt cccagaatgt   8400

cagcctcatt ttcgatttac tggctcttgt tgctgtatgt catgctgacc ttattgttaa   8460

acacaggttt gtttgctttt tttccactca tggagacatg ggagaggcat tatttttaag   8520

ctggttgaaa gctttaaccg ataaagcatt tttagagaaa tgtgaatcag gcagctaaga   8580

aagcatactc tgtccattac ggtaaagaaa atgcacagat tattaactct gcagtgtggc   8640

attagtgtcc tggtcaatat tcggatagat atgaataaaa tatttaaatg gtattgtaaa   8700

tagttttcag gacatatgct atagcttatt tttattatct tttgaaattg ctcttaatac   8760

atcaaatcct gatgtattca atttatcaga tataaattat tctaaatgaa gcccagttaa   8820

atgtttttgt cttgtcagtt atatgttaag tttctgatct ctttgtctat gacgtttact   8880

aatctgcatt tttactgtta tgaattattt tagacagcag tggtttcaag ctttttgcca   8940

ctaaaaatac cttttatttt ctcctccccc agaaaagtct ataccttgaa gtatctatcc   9000

accaaactgt acttctatta agaaatagtt attgtgtttt cttaatgttt tgttattcaa   9060

agacatatca atgaaagctg ctgagcagca tgaataacaa ttatatccac acagatttga   9120

tatattttgt gcagccttaa cttgatagta taaaatgtca ttgcttttta aataatagtt   9180

agtcaatgga cttctatcat agctttccta aactaggtta agatccagag ctttggggtc   9240

ataatatatt acatacaatt aagttatctt tttctaaggg ctttaaaatt catgagaata   9300

accaaaaaag gtatgtggag agttaataca aacataccat attcttgttg aaacagagat   9360

gtggctctgc ttgttctcca taaggtagaa atactttcca gaatttgcct aaactagtaa   9420

gccctgaatt tgctatgatt agggatagga agagattttc acatggcaga ctttagaatt   9480

cttcacttta gccagtaaag tatctccttt tgatcttagt attctgtgta ttttaacttt   9540

tctgagttgt gcatgtttat aagaaaaatc agcacaaagg gtttaagtta aagccttttt   9600

actgaaattt gaaagaaaca gaagaaaata tcaaagttct ttgtattttg agaggattaa   9660

atatgattta caaaagttac atggagggct ctctaaaaca ttaaattaat tattttttgt   9720

tgaaaagtct tactttaggc atcattttat tcctcagcaa ctagctgtga agcctttact   9780

gtgctgtatg ccagtcactc tgctagattg tggagattac cagtgttccc gtcttctccg   9840

agcttagagt tggatgggga ataaagacag gtaaacagat agctacaata ttgtactgtg   9900

aatgcttatg ctggaggaag tacagggaac tattggagca cctaagagga gcacctacct   9960

tgaatttagg ggttagcaga ggcatcctga aaaaagtcaa agctaagcca caatctataa  10020

gcagtttagg aattagcaga acgtgcgtgg tgaggagatg ccaaaggcaa gaagagaaga  10080

gtattccaaa caggagggat tccaaagaga gaagagtatc ccaaacaaca tttgcacaaa  10140

cctgatgggg agagagaatg tggggtgggg atggatgatg agactgaaga agaaagccag  10200

gtctagataa tcagtggcct tgtacaccat gttaaagagt gtagacttga ttctgttgta  10260

aacaggaaag cagcacaatt catatgaata ttttagaaga ctcccactgg aatatggaga  10320

ataaagttgg agatgactaa tcctggaagc agggagaaca tttttgagga agttgcacta  10380

ttttggtgaa aatgatgatc ataaacatga agaattgtag gtgatcatga cctcctctct  10440

aattttccag aagggttttg gaagatataa cataggaaca ttgacaggac tgacgaaagg  10500

agatgaaata caccatataa attgtcaaac acaaggccag atgtctaatt attttgctta  10560

tgtgttgaaa ttacaaattt ttcatcagga aaccaaaaac tacaaaactt agttttccca  10620

agtcccagaa ttctatctgt ccaaacaatc tgtaccactc cacctatatc cctacctttg  10680

catgtctgtc caacctcaaa gtccaggtct atacacacgg gtaagactag agcagttcaa  10740

gtttcagaaa atgagaaaga ggaactgagt tgtgctgaac ccatacaaaa taaacacatt  10800

ctttgtatag attcttggaa cctcgagagg aattcaccta actcataggt atttgatggt  10860

atgaatccat ggctgggctc ggcttttaaa aagccttatc tgggattcct tctatggaac  10920

caagttccat caaagcccat ttaaaagcct acattaaaaa caaaattctt gctgcattgt  10980

atacaaataa tgatgtcatg atcaaataat cagatgccat tatcaagtgg aattacaaaa  11040

tggtataccc actccaaaaa aaaaaaaaaa gctaaattct cagtagaaca ttgtgacttc  11100

atgagccctc cacagccttg gagctgagga gggagcactg gtgagcagta ggttgaagag  11160

aaaacttggc gcttaataat ctatccatgt tttttcatct aaaagagcct tctttttgga  11220

ttaccttatt caatttccat caaggaaatt gttagttcca ctaaccagac agcagctggg  11280

aaggcagaag cttactgtat gtacatggta gctgtgggaa ggaggtttct ttctccaggt  11340

cctcactggc catacaccag tcccttgtta gttatgcctg gtcatagacc cccgttgcta  11400

tcatctcata tttaagtctt tggcttgtga atttatctat tctttcagct tcagcactgc  11460

agagtgctgg gactttgcta acttccattt cttgctggct tagcacattc ctcataggcc  11520

cagctctttt ctcatctggc cctgctgtgg agtcaccttg ccccttcagg agagccatgg  11580

cttaccactg cctgctaagc ctccactcag ctgccaccac actaaatcca agcttctcta  11640

agatgttgca gactttacag gcaagcataa aaggcttgat cttcctggac ttccctttac  11700

ttgtctgaat ctcacctcct tcaactttca gtctcagaat gtaggcattt gtcctctttg  11760

ccctacatct tccttcttct gaatcatgaa agcctctcac ttcctcttgc tatgtgctgg  11820

aggcttctgt caggttttag aatgagttct catctagtcc tagtagcttt tgatgcttaa  11880

gtccaccttt taaggatacc tttgagattt agaccatgtt tttcgcttga gaaagcccta  11940

atctccagac ttgcctttct gtggatttca aagaccaact gaggaagtca aaagctgaat  12000

gttgactttc tttgaacatt tccgctataa caattccaat tctcctcaga gcaatatgcc  12060

tgcctccaac tgaccaggag aaaggtccag tgccaaagag aaaaacacaa agattaatta  12120

tttcagttga gcacatactt tcaaagtggt ttgggtattc atatgaggtt ttctgtcaag  12180

agggtgagac tcttcatcta tccatgtgtg cctgacagtt ctcctggcac tggctggtaa  12240

cagatgcaaa actgtaaaaa ttaagtgatc atgtatttta acgatatcat cacatactta  12300

ttttctatgt aatgttttaa atttccccta acatactttg actgttttgc acatggtaga  12360

tattcacatt tttttgtgtt gaagttgatg caatcttcaa agttatctac cccgttgctt  12420

attagtaaaa ctagtgttaa tacttggcaa gagatgcagg gaatctttct catgactcac  12480

gccctattta gttattaatg ctactaccct attttgagta agtagtaggt ccctaagtac  12540

attgtccaga gttatacttt taaagatatt tagccccata tacttcttga atctaaagtc  12600

atacaccttg ctcctcattt ctgagtggga aagacatttg agagtatgtt gacaattgtt  12660

ctgaaggttt ttgccaagaa ggtgaaactg tcctttcatc tgtgtatgcc tggggctggg  12720

tccctggcag tgatggggtg acaatgcaaa gctgtaaaaa ctaggtgcta gtgggcacct  12780

aatatcatca tcatatactt attttcaagc taatatgcaa aatcccatct ctgtttttaa  12840

actaagtgta gatttcagag aaaatatttt gtggttcaca taagaaaaca gtctactcag  12900

cttgacaagt gttttatgtt aaattggctg gtggtttgaa atgaatcatc ttcacataat  12960

gttttcttta aaaatattgt gaatttaact ctaattcttg ttattctgtg tgataataaa  13020

gaataaacta atttcta                                                 13037


<210>  4
<211>  4314
<212>  DNA
<213>  Homo sapiens - AR- Androgen receptor (NM_000044+2)

<400>  4
cgagatcccg gggagccagc ttgctgggag agcgggacgg tccggagcaa gcccagaggc     60

agaggaggcg acagagggaa aaagggccga gctagccgct ccagtgctgt acaggagccg    120

aagggacgca ccacgccagc cccagcccgg ctccagcgac agccaacgcc tcttgcagcg    180

cggcggcttc gaagccgccg cccggagctg ccctttcctc ttcggtgaag tttttaaaag    240

ctgctaaaga ctcggaggaa gcaaggaaag tgcctggtag gactgacggc tgcctttgtc    300

ctcctcctct ccaccccgcc tccccccacc ctgccttccc cccctccccc gtcttctctc    360

ccgcagctgc ctcagtcggc tactctcagc caacccccct caccaccctt ctccccaccc    420

gcccccccgc ccccgtcggc ccagcgctgc cagcccgagt ttgcagagag gtaactccct    480

ttggctgcga gcgggcgagc tagctgcaca ttgcaaagaa ggctcttagg agccaggcga    540

ctggggagcg gcttcagcac tgcagccacg acccgcctgg ttaggctgca cgcggagaga    600

accctctgtt ttcccccact ctctctccac ctcctcctgc cttccccacc ccgagtgcgg    660

agccagagat caaaagatga aaaggcagtc aggtcttcag tagccaaaaa acaaaacaaa    720

caaaaacaaa aaagccgaaa taaaagaaaa agataataac tcagttctta tttgcaccta    780

cttcagtgga cactgaattt ggaaggtgga ggattttgtt tttttctttt aagatctggg    840

catcttttga atctaccctt caagtattaa gagacagact gtgagcctag cagggcagat    900

cttgtccacc gtgtgtcttc ttctgcacga gactttgagg ctgtcagagc gctttttgcg    960

tggttgctcc cgcaagtttc cttctctgga gcttcccgca ggtgggcagc tagctgcagc   1020

gactaccgca tcatcacagc ctgttgaact cttctgagca agagaagggg aggcggggta   1080

agggaagtag gtggaagatt cagccaagct caaggatgga agtgcagtta gggctgggaa   1140

gggtctaccc tcggccgccg tccaagacct accgaggagc tttccagaat ctgttccaga   1200

gcgtgcgcga agtgatccag aacccgggcc ccaggcaccc agaggccgcg agcgcagcac   1260

ctcccggcgc cagtttgctg ctgctgcagc agcagcagca gcagcagcag cagcagcagc   1320

agcagcagca gcagcagcag cagcagcagc agcaagagac tagccccagg cagcagcagc   1380

agcagcaggg tgaggatggt tctccccaag cccatcgtag aggccccaca ggctacctgg   1440

tcctggatga ggaacagcaa ccttcacagc cgcagtcggc cctggagtgc caccccgaga   1500

gaggttgcgt cccagagcct ggagccgccg tggccgccag caaggggctg ccgcagcagc   1560

tgccagcacc tccggacgag gatgactcag ctgccccatc cacgttgtcc ctgctgggcc   1620

ccactttccc cggcttaagc agctgctccg ctgaccttaa agacatcctg agcgaggcca   1680

gcaccatgca actccttcag caacagcagc aggaagcagt atccgaaggc agcagcagcg   1740

ggagagcgag ggaggcctcg ggggctccca cttcctccaa ggacaattac ttagggggca   1800

cttcgaccat ttctgacaac gccaaggagt tgtgtaaggc agtgtcggtg tccatgggcc   1860

tgggtgtgga ggcgttggag catctgagtc caggggaaca gcttcggggg gattgcatgt   1920

acgccccact tttgggagtt ccacccgctg tgcgtcccac tccttgtgcc ccattggccg   1980

aatgcaaagg ttctctgcta gacgacagcg caggcaagag cactgaagat actgctgagt   2040

attccccttt caagggaggt tacaccaaag ggctagaagg cgagagccta ggctgctctg   2100

gcagcgctgc agcagggagc tccgggacac ttgaactgcc gtctaccctg tctctctaca   2160

agtccggagc actggacgag gcagctgcgt accagagtcg cgactactac aactttccac   2220

tggctctggc cggaccgccg ccccctccgc cgcctcccca tccccacgct cgcatcaagc   2280

tggagaaccc gctggactac ggcagcgcct gggcggctgc ggcggcgcag tgccgctatg   2340

gggacctggc gagcctgcat ggcgcgggtg cagcgggacc cggttctggg tcaccctcag   2400

ccgccgcttc ctcatcctgg cacactctct tcacagccga agaaggccag ttgtatggac   2460

cgtgtggtgg tggtgggggt ggtggcggcg gcggcggcgg cggcggcggc ggcggcggcg   2520

gcggcggcgg cggcgaggcg ggagctgtag ccccctacgg ctacactcgg ccccctcagg   2580

ggctggcggg ccaggaaagc gacttcaccg cacctgatgt gtggtaccct ggcggcatgg   2640

tgagcagagt gccctatccc agtcccactt gtgtcaaaag cgaaatgggc ccctggatgg   2700

atagctactc cggaccttac ggggacatgc gtttggagac tgccagggac catgttttgc   2760

ccattgacta ttactttcca ccccagaaga cctgcctgat ctgtggagat gaagcttctg   2820

ggtgtcacta tggagctctc acatgtggaa gctgcaaggt cttcttcaaa agagccgctg   2880

aagggaaaca gaagtacctg tgcgccagca gaaatgattg cactattgat aaattccgaa   2940

ggaaaaattg tccatcttgt cgtcttcgga aatgttatga agcagggatg actctgggag   3000

cccggaagct gaagaaactt ggtaatctga aactacagga ggaaggagag gcttccagca   3060

ccaccagccc cactgaggag acaacccaga agctgacagt gtcacacatt gaaggctatg   3120

aatgtcagcc catctttctg aatgtcctgg aagccattga gccaggtgta gtgtgtgctg   3180

gacacgacaa caaccagccc gactcctttg cagccttgct ctctagcctc aatgaactgg   3240

gagagagaca gcttgtacac gtggtcaagt gggccaaggc cttgcctggc ttccgcaact   3300

tacacgtgga cgaccagatg gctgtcattc agtactcctg gatggggctc atggtgtttg   3360

ccatgggctg gcgatccttc accaatgtca actccaggat gctctacttc gcccctgatc   3420

tggttttcaa tgagtaccgc atgcacaagt cccggatgta cagccagtgt gtccgaatga   3480

ggcacctctc tcaagagttt ggatggctcc aaatcacccc ccaggaattc ctgtgcatga   3540

aagcactgct actcttcagc attattccag tggatgggct gaaaaatcaa aaattctttg   3600

atgaacttcg aatgaactac atcaaggaac tcgatcgtat cattgcatgc aaaagaaaaa   3660

atcccacatc ctgctcaaga cgcttctacc agctcaccaa gctcctggac tccgtgcagc   3720

ctattgcgag agagctgcat cagttcactt ttgacctgct aatcaagtca cacatggtga   3780

gcgtggactt tccggaaatg atggcagaga tcatctctgt gcaagtgccc aagatccttt   3840

ctgggaaagt caagcccatc tatttccaca cccagtgaag cattggaaac cctatttccc   3900

caccccagct catgccccct ttcagatgtc ttctgcctgt tataactctg cactactcct   3960

ctgcagtgcc ttggggaatt tcctctattg atgtacagtc tgtcatgaac atgttcctga   4020

attctatttg ctgggctttt tttttctctt tctctccttt ctttttcttc ttccctccct   4080

atctaaccct cccatggcac cttcagactt tgcttcccat tgtggctcct atctgtgttt   4140

tgaatggtgt tgtatgcctt taaatctgtg atgatcctca tatggcccag tgtcaagttg   4200

tgcttgttta cagcactact ctgtgccagc cacacaaacg tttacttatc ttatgccacg   4260

ggaagtttag agagctaaga ttatctgggg aaatcaaaac aaaaacaagc aaac         4314


<210>  5
<211>  1765
<212>  DNA
<213>  Homo sapiens AR - Androgen receptor (NM_001011645+1)

<400>  5
gctgcgagca gagagggatt cctcggaggt catctgttcc atcttcttgc ctatgcaaat     60

gcctgcctga agctgctgga ggctggcttt gtaccggact ttgtacaggg aaccagggaa    120

acgaatgcag agtgctcctg acattgcctg tcactttttc ccatgatact ctggcttcac    180

agtttggaga ctgccaggga ccatgttttg cccattgact attactttcc accccagaag    240

acctgcctga tctgtggaga tgaagcttct gggtgtcact atggagctct cacatgtgga    300

agctgcaagg tcttcttcaa aagagccgct gaagggaaac agaagtacct gtgcgccagc    360

agaaatgatt gcactattga taaattccga aggaaaaatt gtccatcttg tcgtcttcgg    420

aaatgttatg aagcagggat gactctggga gcccggaagc tgaagaaact tggtaatctg    480

aaactacagg aggaaggaga ggcttccagc accaccagcc ccactgagga gacaacccag    540

aagctgacag tgtcacacat tgaaggctat gaatgtcagc ccatctttct gaatgtcctg    600

gaagccattg agccaggtgt agtgtgtgct ggacacgaca acaaccagcc cgactccttt    660

gcagccttgc tctctagcct caatgaactg ggagagagac agcttgtaca cgtggtcaag    720

tgggccaagg ccttgcctgg cttccgcaac ttacacgtgg acgaccagat ggctgtcatt    780

cagtactcct ggatggggct catggtgttt gccatgggct ggcgatcctt caccaatgtc    840

aactccagga tgctctactt cgcccctgat ctggttttca atgagtaccg catgcacaag    900

tcccggatgt acagccagtg tgtccgaatg aggcacctct ctcaagagtt tggatggctc    960

caaatcaccc cccaggaatt cctgtgcatg aaagcactgc tactcttcag cattattcca   1020

gtggatgggc tgaaaaatca aaaattcttt gatgaacttc gaatgaacta catcaaggaa   1080

ctcgatcgta tcattgcatg caaaagaaaa aatcccacat cctgctcaag acgcttctac   1140

cagctcacca agctcctgga ctccgtgcag cctattgcga gagagctgca tcagttcact   1200

tttgacctgc taatcaagtc acacatggtg agcgtggact ttccggaaat gatggcagag   1260

atcatctctg tgcaagtgcc caagatcctt tctgggaaag tcaagcccat ctatttccac   1320

acccagtgaa gcattggaaa ccctatttcc ccaccccagc tcatgccccc tttcagatgt   1380

cttctgcctg ttataactct gcactactcc tctgcagtgc cttggggaat ttcctctatt   1440

gatgtacagt ctgtcatgaa catgttcctg aattctattt gctgggcttt ttttttctct   1500

ttctctcctt tctttttctt cttccctccc tatctaaccc tcccatggca ccttcagact   1560

ttgcttccca ttgtggctcc tatctgtgtt ttgaatggtg ttgtatgcct ttaaatctgt   1620

gatgatcctc atatggccca gtgtcaagtt gtgcttgttt acagcactac tctgtgccag   1680

ccacacaaac gtttacttat cttatgccac gggaagttta gagagctaag attatctggg   1740

gaaatcaaaa caaaaacaag caaac                                         1765


<210>  6
<211>  4422
<212>  DNA
<213>  Homo sapiens - CYP19 (Aromatase)

<400>  6
gggagtttct ggagggctga acacgtggag gcaaacagga aggtgaagaa gaacttatcc     60

tatcaggacg gaaggtcctg tgctcgggat cttccagacg tcgcgactct aaattgcccc    120

ctctgaggtc aaggaacaca agatggtttt ggaaatgctg aacccgatac attataacat    180

caccagcatc gtgcctgaag ccatgcctgc tgccaccatg ccagtcctgc tcctcactgg    240

cctttttctc ttggtgtgga attatgaggg cacatcctca ataccaggtc ctggctactg    300

catgggaatt ggacccctca tctcccacgg cagattcctg tggatgggga tcggcagtgc    360

ctgcaactac tacaaccggg tatatggaga attcatgcga gtctggatct ctggagagga    420

aacactcatt atcagcaagt cctcaagtat gttccacata atgaagcaca atcattacag    480

ctctcgattc ggcagcaaac ttgggctgca gtgcatcggt atgcatgaga aaggcatcat    540

atttaacaac aatccagagc tctggaaaac aactcgaccc ttctttatga aagctctgtc    600

aggccccggc cttgttcgta tggtcacagt ctgtgctgaa tccctcaaaa cacatctgga    660

caggttggag gaggtgacca atgaatcggg ctatgtggac gtgttgaccc ttctgcgtcg    720

tgtcatgctg gacacctcta acacgctctt cttgaggatc cctttggacg aaagtgctat    780

cgtggttaaa atccaaggtt attttgatgc atggcaagct ctcctcatca aaccagacat    840

cttctttaag atttcttggc tatacaaaaa gtatgagaag tctgtcaagg atttgaaaga    900

tgccatagaa gttctgatag cagaaaaaag acgcaggatt tccacagaag agaaactgga    960

agaatgtatg gactttgcca ctgagttgat tttagcagag aaacgtggtg acctgacaag   1020

agagaatgtg aaccagtgca tattggaaat gctgatcgca gctcctgaca ccatgtctgt   1080

ctctttgttc ttcatgctat ttctcattgc aaagcaccct aatgttgaag aggcaataat   1140

aaaggaaatc cagactgtta ttggtgagag agacataaag attgatgata tacaaaaatt   1200

aaaagtgatg gaaaacttca tttatgagag catgcggtac cagcctgtcg tggacttggt   1260

catgcgcaaa gccttagaag atgatgtaat cgatggctac ccagtgaaaa aggggacaaa   1320

cattatcctg aatattggaa ggatgcacag actcgagttt ttccccaaac ccaatgaatt   1380

tactcttgaa aattttgcaa agaatgttcc ttataggtac tttcagccat ttggctttgg   1440

gccccgtggc tgtgcaggaa agtacatcgc catggtgatg atgaaagcca tcctcgttac   1500

acttctgaga cgattccacg tgaagacatt gcaaggacag tgtgttgaga gcatacagaa   1560

gatacacgac ttgtccttgc acccagatga gactaaaaac atgctggaaa tgatctttac   1620

cccaagaaac tcagacaggt gtctggaaca ctagagaagg ctggtcagta cccactctgg   1680

agcatttctc atcagtagtt cacatacaaa tcatccatcc ttgccaatag tgtcatcctc   1740

acagtgaaca ctcagtggcc catggcattt tataggcata cctcctatgg gttgtcacca   1800

agctaggtgc tatttgtcat ctgctcctgt tcacaccaga gaaccaggct acaagagaaa   1860

aagcagaggc caagagtttg agggagaaat agtcggtgaa gaaaccgtat ccataaagac   1920

ccgattccac caaatgtgct ttgagaagga taggccttca ttaacaaaat gtatgtctgg   1980

ttccccagta gagctctact gcctcaaccc aaggggattt ttatgtctgg ggcagaaaca   2040

ctcaagttga ttagaaagac caggccaatg tcagggtacc tggggccaaa cccacctgct   2100

agtgtgaatt aaagtacttt aattttgttt tctgtggagg tggaaaagca acattcatag   2160

tctttggaga aatgcttaga aattcagcat ttgacccttg ctgtgaatta agcccaatta   2220

attcctgttt gtctacatat gatctgtctg tggcaaaagt ttaatcagag gaaattcttt   2280

cccagtctgt cgatttatgc ctcagccact tgcctgtgct acaattcatt gtgttacctg   2340

tagattcagg taatacaaac tatatataat catcaagtaa tacaaactaa tttagtaata   2400

gcctgggtta agtattatta gggccctgtg tctgctgtag aaaaaaaaat tcacatgatg   2460

cacttcaaat tcaaataaaa atccttttgg catgttccca tttttgctta gctcaattag   2520

tgtggctaac caagagataa ctgtaaatgt gacattgatt tgctcttact acagcttcag   2580

tgattggggg aggaaaagtc ccaacccaat gggctcaaac ttctaagggg tactcctctc   2640

atccccttat ccttctccct cgacattttc tccctctttc ttcccatgac cccaaagcca   2700

agggcaacag atcagtaaag aacgtggtca gagtagaacc cctgaagtat tttttaatcc   2760

tacctcaaaa tttaacagtt acctgagaga tttaacatta tctagttcat tgaatcattg   2820

tatgtggtca tggataaatt gcacaccttg gaattcgctt tctaaaggaa atcaaatgaa   2880

tggaggaact ttccaaacac cactttactt gtgttatata gccaatataa ctatctctac   2940

tgaatgtcat tgaaaaacta aaaaattaaa cttatttaca aataggtaaa tatttgtcat   3000

tgaatccatt gccatcccat ttgactgttc ttttcatcct actgtctagt aataagctga   3060

gtataagatg acagtgtaat ctccctgaaa gcaggagcta ctttctttct tttgtaatct   3120

atttccatcc ccatttccct gtcctgtctc cctgtattca ctcccaagct cagttctgaa   3180

tagacattcc tgctcagaga tactcccaac tgatgcagaa accaaataaa gaggtaggta   3240

ttccaagaat tcaagaatgg acattagtaa agaataaaac atttatttga gcttggaatt   3300

atttggatca tctatatggc ctaaaaatat atggactatg cctgtgtacc tgaatacgta   3360

tgtagtcagg tcaagacaat catccaaata acttagaccc ctaaaagcaa ggccaggatt   3420

tgcaatttaa tgtgtcccaa ttaattcact tgaaaattag taacactctg tttacgttgc   3480

ctctggctgg agctgcatgg tggaagaagc ccaactttgg atccatgtac ttcacccatc   3540

caatactctt gggacattta tgtgtatttt atctgtatat atgaagccaa tgtctatgtc   3600

tacacagtca aagtgaaatg catgtttgat atagctgtac atagatatct attttgcagg   3660

tacaaaaata tcctggggga aaactgggag tggaagggtg gggggtggga gtgagggaca   3720

tgggggaggg acaggaagag gagaagtgtt ggtttgaacg atccaagcaa actctcccag   3780

aatcaaatta cctgggtagt tgttcaactt ttcactctgc ttagcctgta tagacaaacc   3840

ccatatattt gtagaggctt ggccttggaa ttctggaata ccattggctt ttcagtaggc   3900

tgatgaacac attttgaaaa ttctattatc ttcagaattt tgccccattg ttaagtgctt   3960

aaccgtcact cttgaatgtg caatgtgctg tggattccat tttcatcagt tctgaaagaa   4020

ctgcaatgtg taaattatca gtgaaatgca tgcatataag ggctctatca ttatcaaatt   4080

gtaaggacaa ttgtaccctt ctatatcttt gggcatgcta gacaccccca tgccttcatt   4140

gagatcccat tttccccctc tcaagtggaa aataatcaca tccagcaagc tctctcatta   4200

ttgagaaata ccatttggaa attgccactt tttattccta agcagcacct ttcactgttc   4260

atgatgctaa tgttccacaa aagcatgtgc cattggccca ctgaaggata gagggaccct   4320

tttcaatcta tatcagctgg gctctgggac tgaatctctc acctattctt gcagaaagac   4380

atactaatta aaccttgtca aagtaaaaaa aaaaaaaaaa aa                      4422


<210>  7
<211>  1708
<212>  DNA
<213>  Homo sapiens - SNAI1-Snail homolog 1

<400>  7
ggcacggcct agcgagtggt tcttctgcgc tactgctgcg cgaatcggcg accccagtgc     60

ctcgaccact atgccgcgct ctttcctcgt caggaagccc tccgacccca atcggaagcc    120

taactacagc gagctgcagg actctaatcc agagtttacc ttccagcagc cctacgacca    180

ggcccacctg ctggcagcca tcccacctcc ggagatcctc aaccccaccg cctcgctgcc    240

aatgctcatc tgggactctg tcctggcgcc ccaagcccag ccaattgcct gggcctccct    300

tcggctccag gagagtccca gggtggcaga gctgacctcc ctgtcagatg aggacagtgg    360

gaaaggctcc cagcccccca gcccaccctc accggctcct tcgtccttct cctctacttc    420

agtctcttcc ttggaggccg aggcctatgc tgccttccca ggcttgggcc aagtgcccaa    480

gcagctggcc cagctctctg aggccaagga tctccaggct cgaaaggcct tcaactgcaa    540

atactgcaac aaggaatacc tcagcctggg tgccctcaag atgcacatcc gaagccacac    600

gctgccctgc gtctgcggaa cctgcgggaa ggccttctct aggccctggc tgctacaagg    660

ccatgtccgg acccacactg gcgagaagcc cttctcctgt ccccactgca gccgtgcctt    720

cgctgaccgc tccaacctgc gggcccacct ccagacccac tcagatgtca agaagtacca    780

gtgccaggcg tgtgctcgga ccttctcccg aatgtccctg ctccacaagc accaagagtc    840

cggctgctca ggatgtcccc gctgaccctc gaggctccct cttcctctcc atacctgccc    900

ctgcctgaca gccttcccca gctccagcag gaaggacccc acatccttct cactgccatg    960

gaattccctc ctgagtgccc cacttctggc cacatcagcc ccacaggact ttgatgaaga   1020

ccattttctg gttctgtgtc ctctgcctgg gctctggaag aggccttccc atggccattt   1080

ctgtggaggg agggcagctg gcccccagcc ctgggggatt cctgagctgg cctgtctgcg   1140

tgggtttttg tatccagagc tgtttggata cagctgcttt gagctacagg acaaaggctg   1200

acagactcac tgggaagctc ccaccccact caggggaccc cactcccctc acacacaccc   1260

ccccacaagg aaccctcagg ccaccctcca cgaggtgtga ctaactatgc aataatccac   1320

ccccaggtgc agccccaggg cctgcggagg cggtggcaga ctagagtctg agatgccccg   1380

agcccaggca gctatttcag cctcctgttt ggtggggtgg cacctgtttc ccgggcaatt   1440

taacaatgtc tgaaaaggga ctgtgagtaa tggctgtcac ttgtcggggg cccaagtggg   1500

gtgctctggt ctgaccgatg tgtctcccag aactattctg ggggcccgac aggtgggcct   1560

gggaggaaga tgtttacatt tttaaaggta cactggtatt tatatttcaa acattttgta   1620

tcaaggaaac gttttgtata gttatatgta cagtttattg atattcaata aagcagttaa   1680

tttatatatt aaaaaaaaaa aaaaaaaa                                      1708


<210>  8
<211>  2101
<212>  DNA
<213>  Homo sapiens - SNAI2 - SLUG; Snail homolog 2

<400>  8
agttcgtaaa ggagccgggt gacttcagag gcgccggccc gtccgtctgc cgcacctgag     60

cacggcccct gcccgagcct ggcccgccgc gatgctgtag ggaccgccgt gtcctcccgc    120

cggaccgtta tccgcgccgg gcgcccgcca gacccgctgg caagatgccg cgctccttcc    180

tggtcaagaa gcatttcaac gcctccaaaa agccaaacta cagcgaactg gacacacata    240

cagtgattat ttccccgtat ctctatgaga gttactccat gcctgtcata ccacaaccag    300

agatcctcag ctcaggagca tacagcccca tcactgtgtg gactaccgct gctccattcc    360

acgcccagct acccaatggc ctctctcctc tttccggata ctcctcatct ttggggcgag    420

tgagtccccc tcctccatct gacacctcct ccaaggacca cagtggctca gaaagcccca    480

ttagtgatga agaggaaaga ctacagtcca agctttcaga cccccatgcc attgaagctg    540

aaaagtttca gtgcaattta tgcaataaga cctattcaac tttttctggg ctggccaaac    600

ataagcagct gcactgcgat gcccagtcta gaaaatcttt cagctgtaaa tactgtgaca    660

aggaatatgt gagcctgggc gccctgaaga tgcatattcg gacccacaca ttaccttgtg    720

tttgcaagat ctgcggcaag gcgttttcca gaccctggtt gcttcaagga cacattagaa    780

ctcacacggg ggagaagcct ttttcttgcc ctcactgcaa cagagcattt gcagacaggt    840

caaatctgag ggctcatctg cagacccatt ctgatgtaaa gaaataccag tgcaaaaact    900

gctccaaaac cttctccaga atgtctctcc tgcacaaaca tgaggaatct ggctgctgtg    960

tagcacactg agtgacgcaa tcaatgttta ctcgaacaga atgcatttct tcactccgaa   1020

gccaaatgac aaataaagtc caaaggcatt ttctcctgtg ctgaccaacc aaataatatg   1080

tatagacaca cacacatatg cacacacaca cacacacacc cacagagaga gagctgcaag   1140

agcatggaat tcatgtgttt aaagataatc ctttccatgt gaagtttaaa attactatat   1200

atttgctgat ggctagattg agagaataaa agacagtaac ctttctcttc aaagataaaa   1260

tgaaaagcac attgcatctt ttcttcctaa aaaaatgcaa agatttacat tgctgccaaa   1320

tcatttcaac tgaaaagaac agtattgctt tgtaatagag tctgtaatag gatttcccat   1380

aggaagagat ctgccagacg cgaactcagg tgccttaaaa agtattccaa gtttactcca   1440

ttacatgtcg gttgtctggt tgccattgtt gaactaaagc ctttttttga ttacctgtag   1500

tgctttaaag tatattttta aaagggagga aaaaaataac aagaacaaaa cacaggagaa   1560

tgtattaaaa gtatttttgt tttgttttgt ttttgccaat taacagtatg tgccttgggg   1620

gaggagggaa agattagctt tgaacattcc tggcgcatgc tccattgtct tactatttta   1680

aaacatttta ataatttttg aaaattaatt aaagatggga ataagtgcaa aagaggattc   1740

ttacaaattc attaatgtac ttaaactatt tcaaatgcat accacaaatg caataataca   1800

ataccccttc caagtgcctt tttaaattgt atagttgatg agtcaatgta aatttgtgtt   1860

tatttttata tgattgaatg agttctgtat gaaactgaga tgttgtctat agctatgtct   1920

ataaacaacc tgaagacttg tgaaatcaat gtttcttttt taaaaaacaa ttttcaagtt   1980

ttttttacaa taaacagttt tgatttaaaa tctcgtttgt atactatttt cagagacttt   2040

acttgcttca tgattagtac caaaccactg tacaaagaat tgtttgttaa caagaaaaaa   2100

a                                                                   2101


<210>  9
<211>  1713
<212>  DNA
<213>  Homo sapiens - SNAI3 SMUC; Snail homolog 3

<400>  9
cagcagtccg gacccaggcg cgcccctccc gccccagccc accccggcct gccgcccggg     60

aggggaacat gccgcgctcc ttcctggtga aaacgcactc cagccacagg gtccccaact    120

accggcggct ggagacgcag agagaaatca atggtgcctg ctctgcctgt ggggggctgg    180

tggtgcccct cctcccccga gacaaggagg ccccttctgt gcccggtgac cttccccagc    240

cctgggaccg ctcctcggcc gtcgcctgca tctccctgcc cctcctgcca cggatcgagg    300

aagctctggg ggcctctggg ctggacgcct tggaagtcag cgaggtcgac cctcgggcca    360

gccgggccgc cattgtaccc ctcaaagaca gcctgaacca cctcaacctg cccccactgc    420

tggtgctgcc cacacggtgg tccccgacct tgggcccaga ccggcacggg gctccggaaa    480

aactgcttgg ggctgagcgg atgccccgag ccccgggcgg ctttgagtgc ttccactgcc    540

acaaacccta ccacacgctg gccgggctgg ccaggcaccg gcagctgcac tgccacctgc    600

aggtggggcg tgtcttcacc tgcaagtact gcgacaagga gtacaccagc ctgggtgccc    660

tcaagatgca catccgcact cacacgctgc cctgcacctg caagatctgt ggcaaggcct    720

tctccaggcc ctggttactg cagggccatg tccgcaccca cacaggggag aagccctatg    780

cctgctcgca ctgcagcagg gcctttgccg accgctccaa ccttcgggcc catctgcaaa    840

cgcactcaga cgccaagaag taccggtgcc ggcgctgcac caagaccttc tcccgcatgt    900

ccctcctggc gcggcatgag gagtctggct gctgcccggg cccctgagag gcacgtggtc    960

ggcgcaggta ggagggatgg tcctcaccgg gagagctggc gtccctcctg cccccagagg   1020

agccaggagt ctgggagggc ggggcctggc ctcacacttg gtgcgtcctc cacatctgcg   1080

tccaatcaga accaaagaag tccagcgggg gccactgggc cggaggacac tcccccaggc   1140

atcccaccgc gcggagccca ctcagaggag actcctctcc cggggaaggc tttcatcaga   1200

acaagagcca tggttccatt tcgacacggc caggtctccg gggctaccct tccaagagtc   1260

agagcctcgg ggaggtggcc gccagcatgg gccggcactg ccgccggatg gctggcaagg   1320

ctgcctagtt ccattgcagc agaaatgaac agttctgact tatagtgagc accgccctgt   1380

ggcccttcct cagtaggcac aactacctct cagccagccc ccgccagcct ttggtttggg   1440

gtctgggacg agctgcccca tgtcacacgt ctatgtgcat gtgcacacac actcaaacat   1500

gtacacacac gtgccctccc cacctcacta gactctccgg gagatggggc aggactggga   1560

gagcccacga ttggtgattt gggtgtgttg ggatgaggcg gagtgcctgt gggatttgtc   1620

ccggtcagag cctcaggggg ctggggtctc agggcactca gcttcccagg caataacagc   1680

cgtggggtaa taaatggtct ctgcacacct gca                                1713


