                         SEQUENCE LISTING

<110>  Nevada Cancer Institute
       Xu, C. Wilson
       Barnett, Tamara L.
 
<120>  INDUCTION OF MAMMALIAN CELL PLURIPOTENCY WITH PURIFIED PROTEINS

<130>  NVCI-009/01WO

<150>  US 61/172,168
<151>  2009-04-23

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus

<400>  1

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  2
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  Penetratin 1 peptide

<400>  2

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  3
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Xho-Oct4-F

<400>  3
gatcctcgag atggctggac acctggcttc ag                                     32


<210>  4
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Eco-Oct4-R

<400>  4
gatcgaattc tcagtttgaa tgcatgggag agc                                    33


<210>  5
<211>  1059
<212>  DNA
<213>  Mus sp.

<400>  5
atggctggac acctggcttc agacttcgcc ttctcacccc caccaggtgg gggtgatggg       60

tcagcagggc tggagccggg ctgggtggat cctcgaacct ggctaagctt ccaagggcct      120

ccaggtgggc ctggaatcgg accaggctca gaggtattgg ggatctcccc atgtccgccc      180

gcatacgagt tctgcggagg gatggcatac tgtggacctc aggttggact gggcctagtc      240

ccccaagttg gcgtggagac tttgcagcct gagggccagg caggagcacg agtggaaagc      300

aactcagagg gaacctcctc tgagccctgt gccgaccgcc ccaatgccgt gaagttggag      360

aaggtggaac caactcccga ggagtcccag gacatgaaag ccctgcagaa ggagctagaa      420

cagtttgcca agctgctgaa gcagaagagg atcaccttgg ggtacaccca ggccgacgtg      480

gggctcaccc tgggcgttct ctttggaaag gtgttcagcc agaccaccat ctgtcgcttc      540

gaggccttgc agctcagcct taagaacatg tgtaagctgc ggcccctgct ggagaagtgg      600

gtggaggaag ccgacaacaa tgagaacctt caggagatat gcaaatcgga gaccctggtg      660

caggcccgga agagaaagcg aactagcatt gagaaccgtg tgaggtggag tctggagacc      720

atgtttctga agtgcccgaa gccctcccta cagcagatca ctcacatcgc caatcagctt      780

gggctagaga aggatgtggt tcgagtatgg ttctgtaacc ggcgccagaa gggcaaaaga      840

tcaagtattg agtattccca acgagaagag tatgaggcta cagggacacc tttcccaggg      900

ggggctgtat cctttcctct gcccccaggt ccccactttg gcaccccagg ctatggaagc      960

ccccacttca ccacactcta ctcagtccct tttcctgagg gcgaggcctt tccctctgtt     1020

cccgtcactg ctctgggctc tcccatgcat tcaaactga                            1059


<210>  6
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Xho-Sox2-F

<400>  6
gatcctcgag atgtataaca tgatggagac g                                      31


<210>  7
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Eco-Sox2-R

<400>  7
gatcgaattc tcacatgtgc gacaggggca gtg                                    33


<210>  8
<211>  960
<212>  DNA
<213>  Mus sp.

<400>  8
atgtataaca tgatggagac ggagctgaag ccgccgggcc cgcagcaagc ttcggggggc       60

ggcggcggag gaggcaacgc cacggcggcg gcgaccggcg gcaaccagaa gaacagcccg      120

gaccgcgtca agaggcccat gaacgccttc atggtatggt cccgggggca gcggcgtaag      180

atggcccagg agaaccccaa gatgcacaac tcggagatca gcaagcgcct gggcgcggag      240

tggaaacttt tgtccgagac cgagaagcgg ccgttcatcg acgaggccaa gcggctgcgc      300

gctctgcaca tgaaggagca cccggattat aaataccggc cgcggcggaa aaccaagacg      360

ctcatgaaga aggataagta cacgcttccc ggaggcttgc tggcccccgg cgggaacagc      420

atggcgagcg gggttggggt gggcgccggc ctgggtgcgg gcgtgaacca gcgcatggac      480

agctacgcgc acatgaacgg ctggagcaac ggcagctaca gcatgatgca ggagcagctg      540

ggctacccgc agcacccggg cctcaacgct cacggcgcgg cacagatgca accgatgcac      600

cgctacgacg tcagcgccct gcagtacaac tccatgacca gctcgcagac ctacatgaac      660

ggctcgccca cctacagcat gtcctactcg cagcagggca cccccggtat ggcgctgggc      720

tccatgggct ctgtggtcaa gtccgaggcc agctccagcc cccccgtggt tacctcttcc      780

tcccactcca gggcgccctg ccaggccggg gacctccggg acatgatcag catgtacctc      840

cccggcgccg aggtgccgga gcccgctgcg cccagtagac tgcacatggc ccagcactac      900

cagagcggcc cggtgcccgg cacggccatt aacggcacac tgcccctgtc gcacatgtga      960


<210>  9
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Xho-KLF4-F

<400>  9
gatcctcgag gctgtcagcg acgctctgct c                                      31


<210>  10
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Eco-Klf4-R

<400>  10
gatcgaattc ttaaaagtgc ctcttcatgt gtaag                                  35


<210>  11
<211>  1452
<212>  DNA
<213>  Mus sp.

<400>  11
atgaggcagc cacctggcga gtctgacatg gctgtcagcg acgctctgct cccgtccttc       60

tccacgttcg cgtccggccc ggcgggaagg gagaagacac tgcgtccagc aggtgccccg      120

actaaccgtt ggcgtgagga actctctcac atgaagcgac ttcccccact tcccggccgc      180

ccctacgacc tggcggcgac ggtggccaca gacctggaga gtggcggagc tggtgcagct      240

tgcagcagta acaacccggc cctcctagcc cggagggaga ccgaggagtt caacgacctc      300

ctggacctag actttatcct ttccaactcg ctaacccacc aggaatcggt ggccgccacc      360

gtgaccacct cggcgtcagc ttcatcctcg tcttccccgg cgagcagcgg ccctgccagc      420

gcgccctcca cctgcagctt cagctatccg atccgggccg ggggtgaccc gggcgtggct      480

gccagcaaca caggtggagg gctcctctac agccgagaat ctgcgccacc tcccacggcc      540

cccttcaacc tggcggacat caatgacgtg agcccctcgg gcggcttcgt ggctgagctc      600

ctgcggccgg agttggaccc agtatacatt ccgccacagc agcctcagcc gccaggtggc      660

gggctgatgg gcaagtttgt gctgaaggcg tctctgacca cccctggcag cgagtacagc      720

agcccttcgg tcatcagtgt tagcaaagga agcccagacg gcagccaccc cgtggtagtg      780

gcgccctaca gcggtggccc gccgcgcatg tgccccaaga ttaagcaaga ggcggtcccg      840

tcctgcacgg tcagccggtc cctagaggcc catttgagcg ctggacccca gctcagcaac      900

ggccaccggc ccaacacaca cgacttcccc ctggggcggc agctccccac caggactacc      960

cctacactga gtcccgagga actgctgaac agcagggact gtcaccctgg cctgcctctt     1020

cccccaggat tccatcccca tccggggccc aactaccctc ctttcctgcc agaccagatg     1080

cagtcacaag tcccctctct ccattatcaa gagctcatgc caccgggttc ctgcctgcca     1140

gaggagccca agccaaagag gggaagaagg tcgtggcccc ggaaaagaac agccacccac     1200

acttgtgact atgcaggctg tggcaaaacc tataccaaga gttctcatct caaggcacac     1260

ctgcgaactc acacaggcga gaaaccttac cactgtgact gggacggctg tgggtggaaa     1320

ttcgcccgct ccgatgaact gaccaggcac taccgcaaac acacagggca ccggcccttt     1380

cagtgccaga agtgtgacag ggccttttcc aggtcggacc accttgcctt acacatgaag     1440

aggcactttt aa                                                         1452


<210>  12
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Xho-Myc-F

<400>  12
gatcctcgag cccctcaacg tgaacttcac c                                      31


<210>  13
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Eco-Myc-R

<400>  13
gatcgaattc ttatgcacca gagtttcgaa gctg                                   34


<210>  14
<211>  1365
<212>  DNA
<213>  Mus sp.

<400>  14
ctggatttcc tttgggcgtt ggaaaccccg cagacagcca cgacgatgcc cctcaacgtg       60

aacttcacca acaggaacta tgacctcgac tacgactccg tacagcccta tttcatctgc      120

gacgaggaag agaatttcta tcaccagcaa cagcagagcg agctgcagcc gcccgcgccc      180

agtgaggata tctggaagaa attcgagctg cttcccaccc cgcccctgtc cccgagccgc      240

cgctccgggc tctgctctcc atcctatgtt gcggtcgcta cgtccttctc cccaagggaa      300

gacgatgacg gcggcggtgg caacttctcc accgccgatc agctggagat gatgaccgag      360

ttacttggag gagacatggt gaaccagagc ttcatctgcg atcctgacga cgagaccttc      420

atcaagaaca tcatcatcca ggactgtatg tggagcggtt tctcagccgc tgccaagctg      480

gtctcggaga agctggcctc ctaccaggct gcgcgcaaag acagcaccag cctgagcccc      540

gcccgcgggc acagcgtctg ctccacctcc agcctgtacc tgcaggacct caccgccgcc      600

gcgtccgagt gcattgaccc ctcagtggtc tttccctacc cgctcaacga cagcagctcg      660

cccaaatcct gtacctcgtc cgattccacg gccttctctc cttcctcgga ctcgctgctg      720

tcctccgagt cctccccacg ggccagccct gagcccctag tgctgcatga ggagacaccg      780

cccaccacca gcagcgactc tgaagaagag caagaagatg aggaagaaat tgatgtggtg      840

tctgtggaga agaggcaaac ccctgccaag aggtcggagt cgggctcatc tccatcccga      900

ggccacagca aacctccgca cagcccactg gtcctcaaga ggtgccacgt ctccactcac      960

cagcacaact acgccgcacc cccctccaca aggaaggact atccagctgc caagagggcc     1020

aagttggaca gtggcagggt cctgaagcag atcagcaaca accgcaagtg ctccagcccc     1080

aggtcctcag acacggagga aaacgacaag aggcggacac acaacgtctt ggaacgtcag     1140

aggaggaacg agctgaagcg cagctttttt gccctgcgtg accagatccc tgaattggaa     1200

aacaacgaaa aggcccccaa ggtagtgatc ctcaaaaaag ccaccgccta catcctgtcc     1260

attcaagcag acgagcacaa gctcacctct gaaaaggact tattgaggaa acgacgagaa     1320

cagttgaaac acaaactcga acagcttcga aactctggtg cataa                     1365


<210>  15
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sall4-F

<400>  15
cagcgccgcc gcggtggatc caccatggcc atgtcgaggc gcaagcaggc g                51


<210>  16
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sall4-R

<400>  16
aagcttcgaa ttcaccgcat gcacttagct gacagcaatc ttattttcct                  50


<210>  17
<211>  3204
<212>  DNA
<213>  Mus sp.

<400>  17
atgtcgaggc gcaagcaggc gaagccccag cacatcaact gggaggaggg ccagggcgag       60

cagcctcagc agctaccgag ccccgacctc gccgaggcgc tggcggcgga ggaacccggt      120

gctccagtga actcccctgg gaactgcgat gaagcctcag aggactccat accggtgaag      180

cggccccggc gggaggacac tcacatctgc aacaaatgct gtgccgagtt ctttagtctc      240

tctgaattca tggaacacaa gaaaagttgc actaaaaccc ctcctgtcct catcatgaat      300

gacagcgagg ggccagtgcc ttcagaggac ttttccagag ctgccctgag ccaccagctg      360

ggcagcccaa gcaataaaga cagtctccag gagaacggca gcagctcggg ggacttgaag      420

aagctgggca cggactccat cctgtacttg aagacagagg ctacccagcc atccacaccc      480

caggacataa gctatttacc caaaggcaaa gtagccaaca ccaatgtgac tctgcaggcg      540

ctccgcggca ccaaggtggc cgtgaaccaa cggggtgcag aggcacccat ggcgcccatg      600

cctgctgccc aaggcatccc ttgggtcctg gagcagatcc tgtgcctgca gcagcagcaa      660

ctccagcaaa tccagcttac ggaacagatt cgcgtccagg tgaacatgtg ggcagcgcac      720

gcgctccact ctggagtggc gggggccgac acgctgaagg ccttaagcag ccatgtgtct      780

cagcaagtgt ccgtgtccca gcaggtgtcg gctgccgtgg ccctgctcag ccagaaagcc      840

tcaaacccag ctctgtcgct cgatgccttg aaacaagcca agctacctca tgccagcgtc      900

ccctccgcag ccagcccgtt gtcctcgggg ttaacgtcct tcaccttgaa gcctgacggg      960

acacgggttc tccccaactt cgtgtctcgc cttcccagtg ccctgctacc tcagactccg     1020

ggctctgtgc tcctgcagag tcccttctcc gctgtgacgc tcgaccagtc caagaaagga     1080

aaggggaaac cccagaacct ctccgcctct gcctcggtgt tagatgtcaa ggccaaggac     1140

gaagtcgtcc tcggtaagca caagtgtagg tactgtccca aggttttcgg gacagatagc     1200

tcccttcaga ttcaccttcg ctcccacacc ggagagagac cttacgtgtg ccctatctgt     1260

ggtcaccgct tcaccaccaa gggcaatctc aaggtccact tacaacgaca ccctgaggtg     1320

aaggcaaacc cccagctgtt ggccgaattc caggacaaag gggcagtgag tgccgcttct     1380

cactatgcac tccctgtccc cgtccctgcc gatgaatcga gtctctctgt agacgccgag     1440

cctgtcccgg tcacgggaac cccttctcta gggctacctc aaaagctcac gtcagggcct     1500

aattccaggg acctcatggg tggctccttg cccaatgaca tgcagccagg gccttctcca     1560

gaaagtgagg cgggccttcc actccttggg gtggggatga tacataatcc cccaaaggct     1620

gggggcttcc agggcactgg ggccccagag tcagggtccg agaccctgaa attgcagcaa     1680

ctagtggaga acatagacaa ggccactact gaccccaacg agtgtctcat ttgtcatcgg     1740

gtcctcagct gtcagagttc cctgaagatg cattaccgta cccacacagg ggagagacca     1800

ttccagtgca agatctgtgg ccgggccttc tccaccaaag gcaacctgaa gacacacctt     1860

ggggttcacc gaaccaacac gaccgtaaag acccaacatt cgtgccccat ctgccagaag     1920

aaattcacca acgccgtcat gttacagcag catatccgga tgcacatggg tggccagatc     1980

cccaacaccc ctctgccaga gagtccctgt gacttcacgg ctcccgagcc cgtggccgtc     2040

agtgagaatg gcagtgccag cggggtctgc caggacgacg cagcagaagg gatggaagcc     2100

gaggaggtct gttctcagga tgttcccagt ggcccctcaa ctgtctctct gccggttccc     2160

agtgcccacc tggcatcgcc ctctctgggc ttctctgtgt tggcctccct ggatacgcag     2220

gggaaagggg ctcttccggc gctggccctg cagaggcaga gcagtcgaga aaacagctcc     2280

ctggagggcg gtgacactgg tccagccaat gactcttcct tgctcgtggg tgaccaggag     2340

tgtcagagcc gaagcccaga tgccacggag accatgtgct accaggcagt gtcacctgcc     2400

aatagccaag ccggaagtgt caagtcccgg tctcccgagg gtcacaaggc cgagggcgtg     2460

gagagctgcc gcgttgacac cgaaggtcgt accagcctcc ctccaacatt tatccgagca     2520

cagcccacct ttgtcaaagt tgaagtgcct ggcacctttg tgggaccccc cagcatgccc     2580

tcgggtatgc cgcctttgct agcatcgcag ccgcagccac gccgccaggc caagcagcac     2640

tgctgcacac ggtgtggaaa gaacttctcg tctgccagtg ccctgcagat ccacgagcga     2700

acacacacgg gagagaagcc tttcgtgtgt aacatatgcg ggcgggcctt caccacgaaa     2760

ggcaacctga aggtacacta catgactcat ggggccaaca ataactccgc ccgccgggga     2820

aggaagctgg ccatagagaa ccccatggcc gcgctgagtg ctgagggaaa gagagcgccc     2880

gaggtgtttt ccaaggagct cctgtccccc gcggtgagtg tggaccccgc ctcctggaac     2940

cagtacacca gcgtcctgaa tgggggtctg gccatgaaga ccaacgagat ctccgtgatc     3000

cagagcggag gcatccccac gctgcctgtg tcgctggggg ccagctctgt ggtgagcaat     3060

ggcacgattt ccaagcttga cggctctcag accggtgtga gcatgcccat gagcgggaac     3120

ggagaaaagc tcgctgttcc cgacggcatg gccaaacacc agttccctca cttcctggag     3180

gaaaataaga ttgctgtcag ctaa                                            3204


<210>  18
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Xho-EGFP-F

<400>  18
gatcctcgag atggtgagca agggcgagga gctg                                   34


<210>  19
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Eco-EGFP-R

<400>  19
gatcgaattc tcagttatct acttgtacag ctcgtccatg c                           41


<210>  20
<211>  728
<212>  DNA
<213>  Unknown

<220>
<223>  EGFP sequence

<400>  20
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtag      720

ataactga                                                               728


<210>  21
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Xho-hsMyc-F

<400>  21
gatcctcgag atgcccctca acgttagctt caccaac                                37


<210>  22
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Eco-hsMyc-R

<400>  22
gatcgaattc ttacgcacaa gagttccgta gctg                                   34


<210>  23
<211>  1365
<212>  DNA
<213>  Homo sapiens

<400>  23
ctggattttt ttcgggtagt ggaaaaccag cagcctcccg cgacgatgcc cctcaacgtt       60

agcttcacca acaggaacta tgacctcgac tacgactcgg tgcagccgta tttctactgc      120

gacgaggagg agaacttcta ccagcagcag cagcagagcg agctgcagcc cccggcgccc      180

agcgaggata tctggaagaa attcgagctg ctgcccaccc cgcccctgtc ccctagccgc      240

cgctccgggc tctgctcgcc ctcctacgtt gcggtcacac ccttctccct tcggggagac      300

aacgacggcg gtggcgggag cttctccacg gccgaccagc tggagatggt gaccgagctg      360

ctgggaggag acatggtgaa ccagagtttc atctgcgacc cggacgacga gaccttcatc      420

aaaaacatca tcatccagga ctgtatgtgg agcggcttct cggccgccgc caagctcgtc      480

tcagagaagc tggcctccta ccaggctgcg cgcaaagaca gcggcagccc gaaccccgcc      540

cgcggccaca gcgtctgctc cacctccagc ttgtacctgc aggatctgag cgccgccgcc      600

tcagagtgca tcgacccctc ggtggtcttc ccctaccctc tcaacgacag cagctcgccc      660

aagtcctgcg cctcgcaaga ctccagcgcc ttctctccgt cctcggattc tctgctctcc      720

tcgacggagt cctccccgca gggcagcccc gagcccctgg tgctccatga ggagacaccg      780

cccaccacca gcagcgactc tgaggaggaa caagaagatg aggaagaaat cgatgttgtt      840

tctgtggaaa agaggcaggc tcctggcaaa aggtcagagt ctggatcacc ttctgctgga      900

ggccacagca aacctcctca cagcccactg gtcctcaaga ggtgccacgt ctccacacat      960

cagcacaact acgcagcgcc tccctccact cggaaggact atcctgctgc caagagggtc     1020

aagttggaca gtgtcagagt cctgagacag atcagcaaca accgaaaatg caccagcccc     1080

aggtcctcgg acaccgagga gaatgtcaag aggcgaacac acaacgtctt ggagcgccag     1140

aggaggaacg agctaaaacg gagctttttt gccctgcgtg accagatccc ggagttggaa     1200

aacaatgaaa aggcccccaa ggtagttatc cttaaaaaag ccacagcata catcctgtcc     1260

gtccaagcag aggagcaaaa gctcatttct gaagaggact tgttgcggaa acgacgagaa     1320

cagttgaaac acaaacttga acagctacgg aactcttgtg cgtaa                     1365


<210>  24
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Nco-hsOct4-F

<400>  24
gatcccatgg cgggacacct ggcttcggat ttc                                    33


<210>  25
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Eco-hsOct4-R

<400>  25
gatcgaattc tcagtttgaa tgcatgggag agc                                    33


<210>  26
<211>  1083
<212>  DNA
<213>  Homo sapiens

<400>  26
atggcgggac acctggcttc ggatttcgcc ttctcgcccc ctccaggtgg tggaggtgat       60

gggccagggg ggccggagcc gggctgggtt gatcctcgga cctggctaag cttccaaggc      120

cctcctggag ggccaggaat cgggccgggg gttgggccag gctctgaggt gtgggggatt      180

cccccatgcc ccccgccgta tgagttctgt ggggggatgg cgtactgtgg gccccaggtt      240

ggagtggggc tagtgcccca aggcggcttg gagacctctc agcctgaggg cgaagcagga      300

gtcggggtgg agagcaactc cgatggggcc tccccggagc cctgcaccgt cacccctggt      360

gccgtgaagc tggagaagga gaagctggag caaaacccgg aggagtccca ggacatcaaa      420

gctctgcaga aagaactcga gcaatttgcc aagctcctga agcagaagag gatcaccctg      480

ggatatacac aggccgatgt ggggctcacc ctgggggttc tatttgggaa ggtattcagc      540

caaacgacca tctgccgctt tgaggctctg cagcttagct tcaagaacat gtgtaagctg      600

cggcccttgc tgcagaagtg ggtggaggaa gctgacaaca atgaaaatct tcaggagata      660

tgcaaagcag aaaccctcgt gcaggcccga aagagaaagc gaaccagtat cgagaaccga      720

gtgagaggca acctggagaa tttgttcctg cagtgcccga aacccacact gcagcagatc      780

agccacatcg cccagcagct tgggctcgag aaggatgtgg tccgagtgtg gttctgtaac      840

cggcgccaga agggcaagcg atcaagcagc gactatgcac aacgagagga ttttgaggct      900

gctgggtctc ctttctcagg gggaccagtg tcctttcctc tggccccagg gccccatttt      960

ggtaccccag gctatgggag ccctcacttc actgcactgt actcctcggt ccctttccct     1020

gagggggaag cctttccccc tgtctccgtc accactctgg gctctcccat gcattcaaac     1080

tga                                                                   1083


<210>  27
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  28
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Xho-hsSox2-F

<400>  28
gatcctcgag atgtacaaca tgatggagac gg                                     32


<210>  29
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Eco-hsSox2-R

<400>  29
gatcgaattc tcacatgtgt gagaggggca gtgt                                   34


<210>  30
<211>  954
<212>  DNA
<213>  Homo sapiens

<400>  30
atgtacaaca tgatggagac ggagctgaag ccgccgggcc cgcagcaaac ttcggggggc       60

ggcggcggca actccaccgc ggcggcggcc ggcggcaacc agaaaaacag cccggaccgc      120

gtcaagcggc ccatgaatgc cttcatggtg tggtcccgcg ggcagcggcg caagatggcc      180

caggagaacc ccaagatgca caactcggag atcagcaagc gcctgggcgc cgagtggaaa      240

cttttgtcgg agacggagaa gcggccgttc atcgacgagg ctaagcggct gcgagcgctg      300

cacatgaagg agcacccgga ttataaatac cggccccggc ggaaaaccaa gacgctcatg      360

aagaaggata agtacacgct gcccggcggg ctgctggccc ccggcggcaa tagcatggcg      420

agcggggtcg gggtgggcgc cggcctgggc gcgggcgtga accagcgcat ggacagttac      480

gcgcacatga acggctggag caacggcagc tacagcatga tgcaggacca gctgggctac      540

ccgcagcacc cgggcctcaa tgcgcacggc gcagcgcaga tgcagcccat gcaccgctac      600

gacgtgagcg ccctgcagta caactccatg accagctcgc agacctacat gaacggctcg      660

cccacctaca gcatgtccta ctcgcagcag ggcacccctg gcatggctct tggctccatg      720

ggttcggtgg tcaagtccga ggccagctcc agcccccctg tggttacctc ttcctcccac      780

tccagggcgc cctgccaggc cggggacctc cgggacatga tcagcatgta tctccccggc      840

gccgaggtgc cggaacccgc cgcccccagc agacttcaca tgtcccagca ctaccagagc      900

ggcccggtgc ccggcacggc cattaacggc acactgcccc tctcacacat gtga            954


<210>  31
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Xho-hsKlf4-F

<400>  32
gatcctcgag atggctgtca gcgacgcgct gct                                    33


<210>  33
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Eco-hsKlf4-R

<400>  33
gatcgaattc ttaaaaatgc ctcttcatgt gtaagg                                 36


<210>  34
<211>  1440
<212>  DNA
<213>  Homo sapiens

<400>  34
atgaggcagc cacctggcga gtctgacatg gctgtcagcg acgcgctgct cccatctttc       60

tccacgttcg cgtctggccc ggcgggaagg gagaagacac tgcgtcaagc aggtgccccg      120

aataaccgct ggcgggagga gctctcccac atgaagcgac ttcccccagt gcttcccggc      180

cgcccctatg acctggcggc ggcgaccgtg gccacagacc tggagagcgg cggagccggt      240

gcggcttgcg gcggtagcaa cctggcgccc ctacctcgga gagagaccga ggagttcaac      300

gatctcctgg acctggactt tattctctcc aattcgctga cccatcctcc ggagtcagtg      360

gccgccaccg tgtcctcgtc agcgtcagcc tcctcttcgt cgtcgccgtc gagcagcggc      420

cctgccagcg cgccctccac ctgcagcttc acctatccga tccgggccgg gaacgacccg      480

ggcgtggcgc cgggcggcac gggcggaggc ctcctctatg gcagggagtc cgctccccct      540

ccgacggctc ccttcaacct ggcggacatc aacgacgtga gcccctcggg cggcttcgtg      600

gccgagctcc tgcggccaga attggacccg gtgtacattc cgccgcagca gccgcagccg      660

ccaggtggcg ggctgatggg caagttcgtg ctgaaggcgt cgctgagcgc ccctggcagc      720

gagtacggca gcccgtcggt catcagcgtc agcaaaggca gccctgacgg cagccacccg      780

gtggtggtgg cgccctacaa cggcgggccg ccgcgcacgt gccccaagat caagcaggag      840

gcggtctctt cgtgcaccca cttgggcgct ggaccccctc tcagcaatgg ccaccggccg      900

gctgcacacg acttccccct ggggcggcag ctccccagca ggactacccc gaccctgggt      960

cttgaggaag tgctgagcag cagggactgt caccctgccc tgccgcttcc tcccggcttc     1020

catccccacc cggggcccaa ttacccatcc ttcctgcccg atcagatgca gccgcaagtc     1080

ccgccgctcc attaccaaga gctcatgcca cccggttcct gcatgccaga ggagcccaag     1140

ccaaagaggg gaagacgatc gtggccccgg aaaaggaccg ccacccacac ttgtgattac     1200

gcgggctgcg gcaaaaccta cacaaagagt tcccatctca aggcacacct gcgaacccac     1260

acaggtgaga aaccttacca ctgtgactgg gacggctgtg gatggaaatt cgcccgctca     1320

gatgaactga ccaggcacta ccgtaaacac acggggcacc gcccgttcca gtgccaaaaa     1380

tgcgaccgag cattttccag gtcggaccac ctcgccttac acatgaagag gcatttttaa     1440


<210>  35
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Val Ser Asp Ala Leu Leu Pro Ser Phe Ser Thr Phe Ala Ser 
1               5                   10                  15      


Gly Pro Ala Gly Arg Glu Lys Thr Leu Arg Gln Ala Gly Ala Pro Asn 
            20                  25                  30          


Asn Arg Trp Arg Glu Glu Leu Ser His Met Lys Arg Leu Pro Pro Val 
        35                  40                  45              


Leu Pro Gly Arg Pro Tyr Asp Leu Ala Ala Ala Thr Val Ala Thr Asp 
    50                  55                  60                  


Leu Glu Ser Gly Gly Ala Gly Ala Ala Cys Gly Gly Ser Asn Leu Ala 
65                  70                  75                  80  


Pro Leu Pro Arg Arg Glu Thr Glu Glu Phe Asn Asp Leu Leu Asp Leu 
                85                  90                  95      


Asp Phe Ile Leu Ser Asn Ser Leu Thr His Pro Pro Glu Ser Val Ala 
            100                 105                 110         


Ala Thr Val Ser Ser Ser Ala Ser Ala Ser Ser Ser Ser Ser Pro Ser 
        115                 120                 125             


Ser Ser Gly Pro Ala Ser Ala Pro Ser Thr Cys Ser Phe Thr Tyr Pro 
    130                 135                 140                 


Ile Arg Ala Gly Asn Asp Pro Gly Val Ala Pro Gly Gly Thr Gly Gly 
145                 150                 155                 160 


Gly Leu Leu Tyr Gly Arg Glu Ser Ala Pro Pro Pro Thr Ala Pro Phe 
                165                 170                 175     


Asn Leu Ala Asp Ile Asn Asp Val Ser Pro Ser Gly Gly Phe Val Ala 
            180                 185                 190         


Glu Leu Leu Arg Pro Glu Leu Asp Pro Val Tyr Ile Pro Pro Gln Gln 
        195                 200                 205             


Pro Gln Pro Pro Gly Gly Gly Leu Met Gly Lys Phe Val Leu Lys Ala 
    210                 215                 220                 


Ser Leu Ser Ala Pro Gly Ser Glu Tyr Gly Ser Pro Ser Val Ile Ser 
225                 230                 235                 240 


Val Ser Lys Gly Ser Pro Asp Gly Ser His Pro Val Val Val Ala Pro 
                245                 250                 255     


Tyr Asn Gly Gly Pro Pro Arg Thr Cys Pro Lys Ile Lys Gln Glu Ala 
            260                 265                 270         


Val Ser Ser Cys Thr His Leu Gly Ala Gly Pro Pro Leu Ser Asn Gly 
        275                 280                 285             


His Arg Pro Ala Ala His Asp Phe Pro Leu Gly Arg Gln Leu Pro Ser 
    290                 295                 300                 


Arg Thr Thr Pro Thr Leu Gly Leu Glu Glu Val Leu Ser Ser Arg Asp 
305                 310                 315                 320 


Cys His Pro Ala Leu Pro Leu Pro Pro Gly Phe His Pro His Pro Gly 
                325                 330                 335     


Pro Asn Tyr Pro Ser Phe Leu Pro Asp Gln Met Gln Pro Gln Val Pro 
            340                 345                 350         


Pro Leu His Tyr Gln Glu Leu Met Pro Pro Gly Ser Cys Met Pro Glu 
        355                 360                 365             


Glu Pro Lys Pro Lys Arg Gly Arg Arg Ser Trp Pro Arg Lys Arg Thr 
    370                 375                 380                 


Ala Thr His Thr Cys Asp Tyr Ala Gly Cys Gly Lys Thr Tyr Thr Lys 
385                 390                 395                 400 


Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr Gly Glu Lys Pro 
                405                 410                 415     


Tyr His Cys Asp Trp Asp Gly Cys Gly Trp Lys Phe Ala Arg Ser Asp 
            420                 425                 430         


Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly His Arg Pro Phe Gln 
        435                 440                 445             


Cys Gln Lys Cys Asp Arg Ala Phe Ser Arg Ser Asp His Leu Ala Leu 
    450                 455                 460                 


His Met Lys Arg His Phe 
465                 470 


<210>  36
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Kpn-hsSall4-F

<400>  36
gatcggtacc atgtcgaggc gcaagcaggc gaaac                                  35


<210>  37
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Eco-hsSall4-R

<400>  37
gatcgaattc ttagctgacc gcaatcttgt tttc                                   34


<210>  38
<211>  3162
<212>  DNA
<213>  Homo sapiens

<400>  38
atgtcgaggc gcaagcaggc gaaaccccag cacatcaact cggaggagga ccagggcgag       60

cagcagccgc agcagcagac cccggagttt gcagatgcgg ccccagcggc gcccgcggcg      120

ggggagctgg gtgctccagt gaaccaccca gggaatgacg aggtggcgag tgaggatgaa      180

gccacagtaa agcggcttcg tcgggaggag acgcacgtct gtgagaaatg ctgtgcggag      240

ttcttcagca tctctgagtt cctggaacat aagaaaaatt gcactaaaaa tccacctgtc      300

ctcatcatga atgacagcga ggggcctgtg ccttcagaag acttctccgg agctgtactg      360

agccaccagc ccaccagtcc cggcagtaag gactgtcaca gggagaatgg cggcagctca      420

gaggacatga aggagaagcc ggatgcggag tctgtggtgt acctaaagac agagacagcc      480

ctgccaccca ccccccagga cataagctat ttagccaaag gcaaagtggc caacactaat      540

gtgaccttgc aggcactacg gggcaccaag gtggcggtga atcagcggag cgcggatgca      600

ctccctgccc ccgtgcctgg tgccaacagc atcccgtggg tcctcgagca gatcttgtgt      660

ctgcagcagc agcagctaca gcagatccag ctcaccgagc agatccgcat ccaggtgaac      720

atgtgggcct cccacgccct ccactcaagc ggggcagggg ccgacactct gaagaccttg      780

ggcagccaca tgtctcagca ggtttctgca gctgtggctt tgctcagcca gaaagctgga      840

agccaaggtc tgtctctgga tgccttgaaa caagccaagc tacctcacgc caacatccct      900

tctgccacca gctccctgtc cccagggctg gcacccttca ctctgaagcc ggatgggacc      960

cgggtgctcc cgaacgtcat gtcccgcctc ccgagcgctt tgcttcctca ggccccgggc     1020

tcggtgctct tccagagccc tttctccact gtggcgctag acacatccaa gaaagggaag     1080

gggaagccac cgaacatctc cgcggtggat gtcaaaccca aagacgaggc ggccctctac     1140

aagcacaagt gtaagtactg tagcaaggtt tttgggactg atagctcctt gcagatccac     1200

ctccgctccc acactggaga gagacccttc gtgtgctctg tctgtggtca tcgcttcacc     1260

accaagggca acctcaaggt gcactttcac cgacatcccc aggtgaaggc aaacccccag     1320

ctgtttgccg agttccagga caaagtggcg gccggcaatg gcatccccta tgcactctct     1380

gtacctgacc ccatagatga accgagtctt tctttagaca gcaaacctgt ccttgtaacc     1440

acctctgtag ggctacctca gaatctttct tcggggacta atcccaagga cctcacgggt     1500

ggctccttgc ccggtgacct gcagcctggg ccttctccag aaagtgaggg tggacccaca     1560

ctccctgggg tgggaccaaa ctataattcc ccaagggctg gtggcttcca agggagtggg     1620

acccctgagc cagggtcaga gaccctgaaa ttgcagcagt tggtggagaa cattgacaag     1680

gccaccactg atcccaacga atgtctcatt tgccaccgag tcttaagctg tcagagctcc     1740

ctcaagatgc attatcgcac ccacaccggg gagagaccgt tccagtgtaa gatctgtggc     1800

cgagcctttt ctaccaaagg taacctgaag acacaccttg gggttcaccg aaccaacaca     1860

tccattaaga cgcagcattc gtgccccatc tgccagaaga agttcactaa tgccgtgatg     1920

ctgcagcaac atattcggat gcacatgggc ggtcagattc ccaacacgcc cctgccagag     1980

aatccctgtg actttacggg ttctgagcca atgaccgtgg gtgagaacgg cagcaccggc     2040

gctatctgcc atgatgatgt catcgaaagc atcgatgtag aggaagtcag ctcccaggag     2100

gctcccagca gctcctccaa ggtccccacg cctcttccca gcatccactc ggcatcaccc     2160

acgctagggt ttgccatgat ggcttcctta gatgccccag ggaaagtggg tcctgcccct     2220

tttaacctgc agcgccaggg cagcagagaa aacggttccg tggagagcga tggcttgacc     2280

aacgactcat cctcgctgat gggagaccag gagtatcaga gccgaagccc agatatcctg     2340

gaaaccacat ccttccaggc actctccccg gccaatagtc aagccgaaag catcaagtca     2400

aagtctcccg atgctgggag caaagcagag agctccgaga acagccgcac tgagatggaa     2460

ggtcggagca gtctcccttc cacgtttatc cgagccccgc cgacctatgt caaggttgaa     2520

gttcctggca catttgtggg accctcgaca ttgtccccag ggatgacccc tttgttagca     2580

gcccagccac gccgacaggc caagcaacat ggctgcacac ggtgtgggaa gaacttctcg     2640

tctgctagcg ctcttcagat ccacgagcgg actcacactg gagagaagcc ttttgtgtgc     2700

aacatttgtg ggcgagcttt taccaccaaa ggcaacttaa aggttcacta catgacacac     2760

ggggcgaaca ataactcagc ccgccgtgga aggaagttgg ccatcgagaa caccatggct     2820

ctgttaggta cggacggaaa aagagtctca gaaatctttc ccaaggaaat cctggcccct     2880

tcagtgaatg tggaccctgt tgtgtggaac cagtacacca gcatgctcaa tggcggtctg     2940

gccgtgaaga ccaatgagat ctctgtgatc cagagtgggg gggttcctac cctcccggtt     3000

tccttggggg ccacctccgt tgtgaataac gccactgtct ccaagatgga tggctcccag     3060

tcgggtatca gtgcagatgt ggaaaaacca agtgctactg acggcgttcc caaacaccag     3120

tttcctcact tcctggaaga aaacaagatt gcggtcagct aa                        3162


<210>  39
<211>  1851
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (337)..(337)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (421)..(421)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1317)..(1317)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1326)..(1326)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1331)..(1331)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1334)..(1334)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1367)..(1367)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1805)..(1805)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1838)..(1838)
<223>  n is a, c, g, or t

<400>  39
atgtcgaggc gcaagcaggc gaaaccccag cacatcaact cggaggagga ccagggcgag       60

cagcagccgc agcagcagac cccggagttt gcagatgcgg ccccagcggc gcccgcggcg      120

ggggagctgg gtgctccagt gaaccaccca gggaatgacg aggtggcgag tgaggatgaa      180

gccacagtaa agcggcttcg tcgggaggag acgcacgtct gtgagaaatg ctgtgcggag      240

ttcttcagca tctctgagtt cctggaacat aagaaaaatt gcactaaaaa tccacctgtc      300

ctcatcatga atgacagcga ggggcctgtg ccttcanaag acttctccgg agctgtactg      360

agccaccagc ccaccagtcc cggcagtgag gactgtcaca gggagaatgg cggcagctca      420

naggacataa aggagaagcc ggatgcggag tctgtggtgt acctaaagac agagacagcc      480

ctgccaccca ccccccagga cataagctat ttagccaaag gcaaagtggc caacactaac      540

gtgaccttgc aggcactacg gggcaccaag gtggcggtga atcagcggag cgcggatgca      600

ctccctgccc ccgtgcctgg tgccaacagc atcccgtggg tcctcgagca gatcttgtgt      660

ctgcagcagc agcagctaca gcagatccag ctcaccgagc agatccgcat ccaggtgaac      720

atgtgggcct cccacgccct ccactcaagc ggggcagggg ccgacactct gaagaccttg      780

ggcagccaca tgtctcagca ggtttctgca gctgtggctt tgctcagcca gaaagctgga      840

agccaaggtc tgtctctgga tgccttgaaa caagccaagc tacctcacgc caacatccct      900

tctgccacca gctccctgtc cccagggctg gcacccttca ctctgaagcc ggatgggacc      960

cgggtgctcc cgaacgtcat gtcccgcctc ccgagcgctt tgcttcctca ggccccgggc     1020

tcggtgctct tccagagccc tttctccact gtggcgctag acacatccaa gaaagggaag     1080

gggaagccac cgaacatctc cgcggtggat gtcaaaccca aagacgaggc ggccctctac     1140

aagcacaagt gtcggagcag tctcccttcc acgtttatcc gagccccgcc gacctatgtc     1200

aaggttgaag ttcctggcac atttgtggga ccctcgacat tgtccccagg gatgacccct     1260

ttgttagcag cccagccacg cggacaggcc aagcaacatg gctgcacacg gtgtggnaag     1320

aacttntcgt ntgntagcgc tcttcagatc cacgagcgga ctcacantgg agagaagcct     1380

tttgtgtgca acatttgtgg gcgagctttt accaccaaag gcaacttaaa ggttcactac     1440

atgacacacg gggcgaacaa taactcagcc cgccgtggaa ggaagttggc catcgagaac     1500

accatggctc tgttaggtac ggacggaaaa agagtctcag aaatctttcc caaggaaatc     1560

ctggcccctt cagtgaatgt ggaccctgtt gtgtggaacc agtacaccag catgctcaat     1620

ggcggtctgg ccgtgaagac caatgagatc tctgtgatcc agagtggggg ggttcctacc     1680

ctcccggttt ccttgggggc cacctccgtt gtgaataacg ccactgtctc caagatggat     1740

ggctcccagt cgggtatcag tgcagatgtg gaaaaaccaa gtgctactga cggcgttccc     1800

aaacnccagt ttcctcactt cctggaagaa aacaagantg cggtcagcta a              1851


<210>  40
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer h-UTf1-F

<400>  40
gatcctcgag atgctgctcc ggccccgcag gccgc                                  35


<210>  41
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer h-UTF1-R

<400>  41
gatcgaattc tcactggcac gggtccctga ggaccc                                 36


<210>  42
<211>  1026
<212>  DNA
<213>  Homo sapiens

<400>  42
atgctgctcc ggccccgcag gccgcccccg ctcgcgcccc ccgcgccgcc ctcgcccgcc       60

agccccgacc ccgagccgcg gacacccgga gacgccccgg ggaccccgcc ccggaggccc      120

gcctcgccca gcgcgctggg ggaactcggg ttgccggtgt ccccgggctc ggcgcagcgc      180

acgccctgga gcgcccggga gacggagctg ctgctgggga cgctgctgca accggccgtg      240

tggcgcgcgc tgctcctgga ccgccgccag gccctgccca cctaccgccg cgtgtcggcc      300

gcgctggccc agcagcaggt gcgccgcacc cccgcgcagt gccgccgccg ctacaagttc      360

cttaaagaca agtttcgcga ggcgcacggc cagccgcccg ggcccttcga cgagcagatc      420

cggaagctca tggggctgct gggcgacaac gggcgcaaac ggcctcgccg ccgctccccg      480

gggtccgggc gcccccagcg cgcccgccgc ccggtcccca acgcgcacgc gccggctccc      540

agcgaaccag acgccacccc gctgcccacc gcccgcgacc gcgacgcgga ccccacctgg      600

acgctccgct tcagcccgtc cccaccgaag tctgcggacg cctcccccgc ccccggctcc      660

ccgccagctc ccgccccgac cgccctcgcc acctgcatcc ccgaggaccg cgcgcccgtc      720

cgcggccccg ggtccccgcc gccacccccg gcccgcgaag accccgactc gccgcccggc      780

cgccccgagg actgcgcgcc ccctccggcc gcgcccccgt cgctgaacac cgccctgctg      840

cagaccctgg ggcacctggg cgacatcgcg aacatcctgg gcccgctgcg cgaccagctg      900

ctgaccttga accagcacgt ggagcagctg cgcggcgcct tcgaccagac agtgtccctg      960

gccgtgggct tcattctggg cagcgcggcc gccgagcgag gggtcctcag ggacccgtgc     1020

cagtga                                                                1026


<210>  43
<211>  1337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse myc codon optimized sequence

<400>  43
gatcctcgag ccactcaacg ttaattttac caatcgtaat tatgacctcg actatgactc       60

agtccagcct tacttcatct gtgatgagga agaaaacttc taccaccaac agcagcaaag      120

cgaactgcaa ccgcccgcgc ctagtgaaga tatttggaaa aaatttgaat tactgccgac      180

cccccccctg tccccgtccc gtcgttcagg actttgtagc ccgtcttatg tggccgtcgc      240

gactagcttt tcacctcgtg aggacgatga tggaggcggt ggcaactttt cgaccgcaga      300

tcaactcgaa atgatgacag aacttttagg cggagatatg gtaaatcagt ctttcatttg      360

tgaccctgat gacgaaacct ttatcaaaaa cattattatt caagattgca tgtggtctgg      420

ctttagcgcc gccgcgaaac ttgtaagcga aaaattagcc tcatatcaag cagcacgcaa      480

agattctacc tcactcagcc ctgcccgcgg acactctgta tgttccacgt cttctctgta      540

cctccaagac cttactgccg cagccagcga atgtattgac ccgagtgttg tgtttccata      600

tccactgaat gattcctcta gtcccaaatc ttgtacctca tccgacagca ccgcattctc      660

gccgagctca gactcactgt tatcctccga aagcagccct cgcgcctccc ccgaaccatt      720

ggttttacac gaagaaacac caccaaccac ttcatccgac tctgaagaag aacaagaaga      780

cgaagaagaa attgatgtag tcagtgtgga aaagcgtcaa accccggcga aacgtagcga      840

atctggttcc tctccctcgc gcggacattc taaaccccca catagccccc tcgttttaaa      900

acgttgtcac gtttcaactc accagcataa ttatgcagca ccaccatcta cccgcaaaga      960

ctatccagca gcaaaacgcg ccaaactcga ttccggccgc gtcctgaagc aaatttctaa     1020

caatcgcaaa tgttcctcac cccgttcatc cgataccgaa gaaaatgata aacgccgtac     1080

ccataacgtt ctggaacgcc aacgccgtaa cgaactgaaa cgttcctttt tcgcattgcg     1140

cgatcagatc ccggagctcg aaaataatga aaaagcacct aaagtagtta tcctgaaaaa     1200

agcaaccgca tatattctga gcattcaagc cgacgaacac aaattaacat ccgaaaaaga     1260

cttattacgt aaacgtcgcg aacaactgaa acataaactg gaacaattac gcaactccgg     1320

agcgtaagaa ttcgatc                                                    1337


<210>  44
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse myc codon optimized sequence

<400>  44

Pro Leu Asn Val Asn Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
1               5                   10                  15      


Ser Val Gln Pro Tyr Phe Ile Cys Asp Glu Glu Glu Asn Phe Tyr His 
            20                  25                  30          


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
        35                  40                  45              


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
    50                  55                  60                  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Ala Thr Ser Phe 
65                  70                  75                  80  


Ser Pro Arg Glu Asp Asp Asp Gly Gly Gly Gly Asn Phe Ser Thr Ala 
                85                  90                  95      


Asp Gln Leu Glu Met Met Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
            100                 105                 110         


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
        115                 120                 125             


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
    130                 135                 140                 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Thr 
145                 150                 155                 160 


Ser Leu Ser Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
                165                 170                 175     


Tyr Leu Gln Asp Leu Thr Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
        195                 200                 205             


Thr Ser Ser Asp Ser Thr Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
    210                 215                 220                 


Ser Ser Glu Ser Ser Pro Arg Ala Ser Pro Glu Pro Leu Val Leu His 
225                 230                 235                 240 


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
                245                 250                 255     


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Thr Pro 
            260                 265                 270         


Ala Lys Arg Ser Glu Ser Gly Ser Ser Pro Ser Arg Gly His Ser Lys 
        275                 280                 285             


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
    290                 295                 300                 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
305                 310                 315                 320 


Ala Lys Arg Ala Lys Leu Asp Ser Gly Arg Val Leu Lys Gln Ile Ser 
                325                 330                 335     


Asn Asn Arg Lys Cys Ser Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
            340                 345                 350         


Asp Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
        355                 360                 365             


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
    370                 375                 380                 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
385                 390                 395                 400 


Tyr Ile Leu Ser Ile Gln Ala Asp Glu His Lys Leu Thr Ser Glu Lys 
                405                 410                 415     


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
            420                 425                 430         


Leu Arg Asn Ser Gly Ala 
        435             


<210>  45
<211>  1340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human myc codon optimized DNA sequence

<400>  45
gatcctcgag atgcccctta atgtctcatt tacgaaccgt aactacgatc ttgattacga       60

cagcgttcaa ccttactttt actgcgatga agaagaaaat ttctatcagc aacaacagca      120

aagcgaactg caacccccgg ccccttcaga ggatatctgg aaaaaattcg aacttttgcc      180

aaccccgccc ctgtcacctt ctcgccgctc tggtttatgc tccccgtcct atgtagccgt      240

cactccattt tccttacgtg gtgataacga cggtggtggc ggtagctttt caaccgccga      300

tcagttagaa atggttaccg aactcttagg cggcgatatg gttaatcagt ctttcatttg      360

tgacccagat gacgaaacct ttattaaaaa cattatcatt caagactgca tgtggtctgg      420

tttctcagcc gccgcaaaac ttgtgtctga aaaacttgca tcctaccaag ctgcccgcaa      480

agattccggc tccccaaacc ccgctcgtgg ccattccgtg tgtagcacct cgtcccttta      540

tttgcaggac ttatcagcag cagcatctga atgtatcgat ccgtccgttg tcttcccata      600

cccgttgaat gactcaagct ctccaaaatc ctgcgcctcc caagattcct ccgcttttag      660

cccctcctcc gatagtctcc tttcttccac cgagagttcc ccacagggat ccccagaacc      720

gttagttttg cacgaagaaa cgcctccaac cacctcaagc gatagcgaag aagaacaaga      780

agatgaagaa gaaattgatg ttgtttccgt tgaaaaacgc caagccccag gtaaacgctc      840

cgaatccggc tctccatccg ctggcggcca ctctaaacca cctcatagcc cgttagtact      900

caaacgctgc catgtctcta cccatcaaca taattatgcc gcacctccaa gtacgcgcaa      960

agactaccca gcagccaaac gcgtgaaact ggatagtgtc cgtgtcctcc gtcaaattag     1020

caataatcgt aaatgcactt ctccccggtc ctcagatact gaagaaaacg taaaacgccg     1080

tactcataac gtcttagaac gtcagcgccg taacgaactg aaacgctcat tttttgcgct     1140

tcgtgatcaa atccccgaat tagaaaataa tgaaaaagcg cctaaagttg ttatcctgaa     1200

aaaagccaca gcctatatct tatccgtaca agccgaagaa caaaaactta tctctgaaga     1260

agatctgctc cgcaaacgcc gtgaacaatt aaaacataaa ctggaacaat tacgtaatag     1320

ctgcgcctaa gaattcgatc                                                 1340


<210>  46
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human myc codon optimized DNA sequence

<400>  46

Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe 
65                  70                  75                  80  


Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala 
                85                  90                  95      


Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
            100                 105                 110         


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
        115                 120                 125             


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
    130                 135                 140                 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly 
145                 150                 155                 160 


Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
                165                 170                 175     


Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
        195                 200                 205             


Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
    210                 215                 220                 


Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
                245                 250                 255     


Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser 
        275                 280                 285             


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
    290                 295                 300                 


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
305                 310                 315                 320 


Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile 
                325                 330                 335     


Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu 
            340                 345                 350         


Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
        355                 360                 365             


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
    370                 375                 380                 


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
385                 390                 395                 400 


Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu 
                405                 410                 415     


Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu 
            420                 425                 430         


Gln Leu Arg Asn Ser Cys Ala 
        435                 


<210>  47
<211>  1103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human oct4 codon optimized DNA sequence

<400>  47
gatcccatgg atggctggtc atcttgcaag tgatttcgcc ttttcacctc ccccaggtgg       60

cggcggtgac ggtccgggcg gtccagaacc aggttgggtt gatccacgca cgtggttaag      120

ttttcaaggt cctccaggtg gtccaggaat tggtcccggt gttggccccg gcagtgaagt      180

gtggggcatc cccccgtgtc ctccccccta tgaattttgc ggtggcatgg cgtattgcgg      240

tcctcaagtt ggtgttggtt tggtcccaca aggtggtctc gaaacctcac aacccgaagg      300

agaagctggc gtgggtgtag aatcaaacag cgatggcgcc tcacctgaac catgcactgt      360

cactcctggc gcggttaaat tggaaaaaga aaaattagag cagaacccag aagaatccca      420

agatatcaaa gcccttcaga aagaattaga acaatttgcc aaactcttga aacaaaaacg      480

tatcactctc ggatatacgc aagccgatgt tggcctgacc ctcggtgtat tattcgggaa      540

agtattttca cagacaacaa tctgccgttt tgaagcactg caactgtctt ttaaaaacat      600

gtgcaaatta cgccccctgc tgcagaaatg ggtcgaagaa gcagataaca atgaaaactt      660

acaggaaatt tgcaaggccg aaaccttagt tcaagctcgc aaacgtaaac gcaccagcat      720

tgaaaatcgt gtacgtggta atctcgaaaa tttattctta cagtgtccta aaccaacttt      780

acagcaaatc agccatatcg ctcagcaact cggtcttgag aaagacgtcg ttcgggtttg      840

gttttgtaat cgtcgtcaaa aaggtaaacg ctcgtcatcc gactacgccc aacgggaaga      900

ttttgaagct gcaggtagtc cctttagtgg cggccccgtt tcgttccccc tcgctccagg      960

cccacatttt ggtaccccag gttacggtag tcctcatttt acagcattat attcatccgt     1020

tccgtttccc gaaggcgagg cattccctcc agtatcggtt actactctcg gctcacctat     1080

gcactccaat taagaattcg atc                                             1103


<210>  48
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Oct4 codon optimized protein sequence

<400>  48

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  49
<211>  974
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Sox2 codon optimized DNA sequence

<400>  49
gatcctcgag atgtacaaca tgatggaaac agaactcaaa cctccaggcc ctcaacaaac       60

ttccggtggt ggcggcggca actcaactgc agcagcagca ggtggtaatc agaaaaatag      120

cccggatcgt gttaaacgcc cgatgaacgc atttatggta tggtcccgcg gtcaacgtcg      180

gaaaatggct caagaaaacc ctaaaatgca taacagcgaa atttctaaac gtttaggtgc      240

tgaatggaaa ctcttatctg aaaccgaaaa acgtccgttt attgatgaag ccaaacgctt      300

gcgcgcgctc cacatgaaag aacatcccga ttataaatac cgtcctcgtc gtaaaaccaa      360

aacgttaatg aaaaaagata aatacactct tccaggtggt ctcttagctc caggcggtaa      420

ctctatggcg tcaggggtcg gggtcggtgc tggactgggg gccggagtta atcagcgtat      480

ggactcttat gcccacatga acggttggtc aaatggcagc tacagcatga tgcaagatca      540

gcttggttat cctcaacatc ccggtttgaa cgctcatggc gcagctcaaa tgcaaccgat      600

gcaccgttac gacgtatccg cattacagta taacagtatg actagctcgc aaacttacat      660

gaatggatca ccgacctaca gtatgagtta ttcacaacaa ggcacccccg gcatggcctt      720

aggctcaatg ggctccgtcg tcaaatccga agcatcctct tccccaccag tcgttacgtc      780

ctcctcacac tctcgtgcac cttgtcaagc tggagattta cgcgatatga tctcaatgta      840

tctccccggc gcagaagtac cagaaccagc cgctccttca cgtcttcaca tgtctcagca      900

ttatcaatct ggccctgttc caggtaccgc aattaacggc acattaccat tatctcacat      960

gtaagaattc gatc                                                        974


<210>  50
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Sox2 codon optimized protein sequence

<400>  50

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  51
<211>  1433
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human klf4 codon optimized DNA sequence

<400>  51
gatcctcgag atggccgtct ccgacgcact gttgcctagc ttcagcacct ttgcttcagg       60

tcccgcaggc cgcgaaaaaa cactccgcca agcaggcgcc cccaataacc gttggcgcga      120

agaactttca catatgaaac gtctgccccc agtgttgccg ggtcgccctt atgatttagc      180

tgcagcgacc gtggccaccg acctcgaatc gggtggagca ggcgcagcct gtggtggcag      240

taatttagcc cctcttcccc gtcgcgaaac tgaagaattt aatgatctgt tagacctcga      300

ctttatttta tccaactctc tcacccatcc accagaatca gtcgccgcaa ctgtttcgtc      360

ctccgcatca gcttcatcgt ctagctctcc gtcgtcaagc ggccctgcat cggccccatc      420

tacatgctct tttacatacc ccatccgcgc tggtaacgat ccgggtgttg ccccaggagg      480

taccggagga ggcttactgt atggtcgcga atcagcccct ccaccgacag ccccgttcaa      540

ccttgccgat attaatgacg tgtcccctag tggtggcttt gtggccgaat tgctgcgtcc      600

agaacttgac cccgtttata tcccgcctca acaacctcag ccccctggcg gtggcctcat      660

gggtaaattt gtcttaaaag caagcttgtc cgcacctggt tccgaatatg gtagtccttc      720

cgttatctct gtttccaagg gttctcctga tggctcccat ccagttgtag ttgcacctta      780

taatggcggt cccccacgta cctgtcctaa aatcaaacag gaagctgttt cctcctgcac      840

acatttaggt gccggccctc ctctgagcaa cggccatcgc ccagcggccc acgatttccc      900

tttaggtcgt caacttccat cccgtacgac accaacctta ggcttagaag aagtcctgtc      960

ctctcgtgac tgccatcctg ctttacctct gcctccaggt tttcatccac atccaggccc     1020

gaattaccct tccttcttac cagatcaaat gcaaccacaa gtccccccct tacactacca     1080

agaactgatg ccaccgggct cctgcatgcc agaagaacca aaaccgaaac gcggccgccg     1140

ttcctggccc cgcaaacgta ccgccaccca cacctgtgac tatgctggtt gcggcaaaac     1200

atacactaaa agttcacacc ttaaagcaca tcttcgtacg catactggcg aaaaacctta     1260

tcactgcgat tgggatggct gtggttggaa attcgcacgc tccgatgagt taacccgtca     1320

ttatcgcaaa catactggac atcgcccatt ccaatgccaa aaatgcgatc gcgcgttttc     1380

ccgttcagac catttagcct tacacatgaa acgccacttt taagaattcg atc            1433


<210>  52
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human klf4 codon optimized protein sequence

<400>  52

Met Ala Val Ser Asp Ala Leu Leu Pro Ser Phe Ser Thr Phe Ala Ser 
1               5                   10                  15      


Gly Pro Ala Gly Arg Glu Lys Thr Leu Arg Gln Ala Gly Ala Pro Asn 
            20                  25                  30          


Asn Arg Trp Arg Glu Glu Leu Ser His Met Lys Arg Leu Pro Pro Val 
        35                  40                  45              


Leu Pro Gly Arg Pro Tyr Asp Leu Ala Ala Ala Thr Val Ala Thr Asp 
    50                  55                  60                  


Leu Glu Ser Gly Gly Ala Gly Ala Ala Cys Gly Gly Ser Asn Leu Ala 
65                  70                  75                  80  


Pro Leu Pro Arg Arg Glu Thr Glu Glu Phe Asn Asp Leu Leu Asp Leu 
                85                  90                  95      


Asp Phe Ile Leu Ser Asn Ser Leu Thr His Pro Pro Glu Ser Val Ala 
            100                 105                 110         


Ala Thr Val Ser Ser Ser Ala Ser Ala Ser Ser Ser Ser Ser Pro Ser 
        115                 120                 125             


Ser Ser Gly Pro Ala Ser Ala Pro Ser Thr Cys Ser Phe Thr Tyr Pro 
    130                 135                 140                 


Ile Arg Ala Gly Asn Asp Pro Gly Val Ala Pro Gly Gly Thr Gly Gly 
145                 150                 155                 160 


Gly Leu Leu Tyr Gly Arg Glu Ser Ala Pro Pro Pro Thr Ala Pro Phe 
                165                 170                 175     


Asn Leu Ala Asp Ile Asn Asp Val Ser Pro Ser Gly Gly Phe Val Ala 
            180                 185                 190         


Glu Leu Leu Arg Pro Glu Leu Asp Pro Val Tyr Ile Pro Pro Gln Gln 
        195                 200                 205             


Pro Gln Pro Pro Gly Gly Gly Leu Met Gly Lys Phe Val Leu Lys Ala 
    210                 215                 220                 


Ser Leu Ser Ala Pro Gly Ser Glu Tyr Gly Ser Pro Ser Val Ile Ser 
225                 230                 235                 240 


Val Ser Lys Gly Ser Pro Asp Gly Ser His Pro Val Val Val Ala Pro 
                245                 250                 255     


Tyr Asn Gly Gly Pro Pro Arg Thr Cys Pro Lys Ile Lys Gln Glu Ala 
            260                 265                 270         


Val Ser Ser Cys Thr His Leu Gly Ala Gly Pro Pro Leu Ser Asn Gly 
        275                 280                 285             


His Arg Pro Ala Ala His Asp Phe Pro Leu Gly Arg Gln Leu Pro Ser 
    290                 295                 300                 


Arg Thr Thr Pro Thr Leu Gly Leu Glu Glu Val Leu Ser Ser Arg Asp 
305                 310                 315                 320 


Cys His Pro Ala Leu Pro Leu Pro Pro Gly Phe His Pro His Pro Gly 
                325                 330                 335     


Pro Asn Tyr Pro Ser Phe Leu Pro Asp Gln Met Gln Pro Gln Val Pro 
            340                 345                 350         


Pro Leu His Tyr Gln Glu Leu Met Pro Pro Gly Ser Cys Met Pro Glu 
        355                 360                 365             


Glu Pro Lys Pro Lys Arg Gly Arg Arg Ser Trp Pro Arg Lys Arg Thr 
    370                 375                 380                 


Ala Thr His Thr Cys Asp Tyr Ala Gly Cys Gly Lys Thr Tyr Thr Lys 
385                 390                 395                 400 


Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr Gly Glu Lys Pro 
                405                 410                 415     


Tyr His Cys Asp Trp Asp Gly Cys Gly Trp Lys Phe Ala Arg Ser Asp 
            420                 425                 430         


Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly His Arg Pro Phe Gln 
        435                 440                 445             


Cys Gln Lys Cys Asp Arg Ala Phe Ser Arg Ser Asp His Leu Ala Leu 
    450                 455                 460                 


His Met Lys Arg His Phe 
465                 470 


<210>  53
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Age/xhoSense

<400>  53
accggtccgc ctaaaaagaa acgcaaagta ctcgag                                 36


<210>  54
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Age/XhoRev-comp

<400>  54
ctcgagtact ttgcgtttct ttttaggcgg accggt                                 36


<210>  55
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Nls-sen (Age/Xho)

<400>  55
ccggtccgcc taaaaagaaa cgcaaagtac                                        30


<210>  56
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Nls-anti(age/Xho)

<400>  56
tcgagtactt tgcgtttctt tttaggcgga                                        30


<210>  57
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Nls-sen (age/xho)-P

<400>  57
ccggtcctaa aaagaaacgc aaagtac                                           27


<210>  58
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Nls-anti(age/Xho)-P

<400>  58
tcgagtactt tgcgtttctt tttagga                                           27


<210>  59
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Nco1NLS sense

<400>  59
ccatggcccc gcctaaaaag aaacgcaaag tagccatgg                              39


<210>  60
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Nco1NLS antisense

<400>  60
ccatggctac tttgcgtttc tttttaggcg gggccatgg                              39


<210>  61
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Nco1NLS sense

<400>  61
catggccccg cctaaaaaga aacgcaaagt agc                                    33


<210>  62
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Nco1NLS antisense

<400>  62
catggctact ttgcgtttct ttttaggcgg ggc                                    33


<210>  63
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Nco1NLS sense-G-P

<400>  63
catggcccct aaaaagaaac gcaaagtac                                         29


<210>  64
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Nco1NLS antisense-G-P

<400>  64
catggtactt tgcgtttctt tttaggggc                                         29


<210>  65
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer HDM2-F

<400>  65
gatcctcgag atgtgcaata ccaacatgtc tgtacc                                 36


<210>  66
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer HDM2-R

<400>  66
gatcgaattc ctaggggaaa taagttagca caatc                                  35


<210>  67
<211>  1476
<212>  DNA
<213>  Unknown

<220>
<223>  HDM2 cloned sequence

<400>  67
atgtgcaata ccaacatgtc tgtacctact gatggtgctg taaccacctc acagattcca       60

gcttcggaac aagagaccct ggttagacca aagccattgc ttttgaagtt attaaagtct      120

gttggtgcac aaaaagacac ttatactatg aaagaggttc ttttttatct tggccagtat      180

attatgacta aacgattata tgatgagaag caacaacata ttgtatattg ttcaaatgat      240

cttctaggag atttgtttgg cgtgccaagc ttctctgtga aagagcacag gaaaatatat      300

accatgatct acaggaactt ggtagtagtc aatcagcagg aatcatcgga ctcaggtaca      360

tctgtgagtg agaacaggtg tcaccttgaa ggtgggagtg atcaaaagga ccttgtacaa      420

gagcttcagg aagagaaacc ttcatcttca catttggttt ctagaccatc tacctcatct      480

agaaggagag caattagtga gacagaagaa aattcagatg aattatctgg tgaacgacaa      540

agaaaacgcc acaaatctga tagtatttcc ctttcctttg atgaaagcct ggctctgtgt      600

gtaataaggg agatatgttg tgaaagaagc agtagcagtg aatctacagg gacgccatcg      660

aatccggatc ttgatgctgg tgtaagtgaa cattcaggtg attggttgga tcaggattca      720

gtttcagatc agtttagtgt agaatttgaa gttgaatctc tcgactcaga agattatagc      780

cttagtgaag aaggacaaga actctcagat gaagatgatg aggtatatca agttactgtg      840

tatcaggcag gggagagtga tacagattca tttgaagaag atcctgaaat ttccttagct      900

gactattgga aatgcacttc atgcaatgaa atgaatcccc cccttccatc acattgcaac      960

agatgttggg cccttcgtga gaattggctt cctgaagata aagggaaaga taaaggggaa     1020

atctctgaga aagccaaact ggaaaactca acacaagctg aagagggctt tgatgttcct     1080

gattgtaaaa aaactatagt gaatgattcc agagagtcat gtgttgagga aaatgatgat     1140

aaaattacac aagcttcaca atcacaagaa agtgaagact attctcagcc atcaacttct     1200

agtagcatta tttatagcag ccaagaagat gtgaaagagt ttgaaaggga agaaacccaa     1260

gacaaagaag agagtgtgga atctagtttg ccccttaatg ccattgaacc ttgtgtgatt     1320

tgtcaaggtc gacctaaaaa tggttgcatt gtccatggca aaacaggaca tcttatggcc     1380

tgctttacat gtgcaaagaa gctaaagaaa aggaataagc cctgcccagt atgtagacaa     1440

ccaattcaaa tgattgtgct aacttatttc ccctag                               1476


<210>  68
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer p53-F

<400>  68
gatcctcgag atggaggagc cgcagtcaga tcc                                    33


<210>  69
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer p53-393R

<400>  69
gatcgaattc tcagtctgag tcaggccctt ctgtc                                  35


<210>  70
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Mdm2-F

<400>  70
gatcctcgag atgtgcaata ccaacatgtc tgtgtc                                 36


<210>  71
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Mdm2-R

<400>  71
gatcgaattc ctagttgaag taacttagca caatc                                  35


<210>  72
<211>  1470
<212>  DNA
<213>  Mus sp.

<400>  72
atgtgcaata ccaacatgtc tgtgtctacc gagggtgctg caagcacctc acagattcca       60

gcttcggaac aagagactct ggttagacca aaaccattgc ttttgaagtt gttaaagtcc      120

gttggagcgc aaaacgacac ttacactatg aaagagatta tattttatat tggccagtat      180

attatgacta agaggttata tgacgagaag cagcagcaca ttgtgtattg ttcaaatgat      240

ctcctaggag atgtgtttgg agtcccgagt ttctctgtga aggagcacag gaaaatatat      300

gcaatgatct acagaaattt agtggctgta agtcagcaag actctggcac atcgctgagt      360

gagagcagac gtcagcctga aggtgggagt gatctgaagg atcctttgca agcgccacca      420

gaagagaaac cttcatcttc tgatttaatt tctagactgt ctacctcatc tagaaggaga      480

tccattagtg agacagaaga gaacacagat gagctacctg gggagcggca ccggaagcgc      540

cgcaggtccc tgtcctttga tccgagcctg ggtctgtgtg agctgaggga gatgtgcagc      600

ggcggcacga gcagcagtag cagcagcagc agcgagtcca cagagacgcc ctcgcatcag      660

gatcttgacg atggcgtaag tgagcattct ggtgattgcc tggatcagga ttcagtttct      720

gatcagttta gcgtggaatt tgaagttgag tctctggact cggaagatta cagcctgagt      780

gacgaagggc acgagctctc agatgaggat gatgaggtct atcgggtcac agtctatcag      840

acaggagaaa gcgatacaga ctcttttgaa ggagatcctg agatttcctt agctgactat      900

tggaagtgta cctcatgcaa tgaaatgaat cctccccttc catcacactg caaaagatgc      960

tggacccttc gtgagaactg gcttccagac gataagggga aagataaagt ggaaatctct     1020

gaaaaagcca aactggaaaa ctcagctcag gcagaagaag gcttggatgt gcctgatggc     1080

aaaaagctga cagagaatga tgctaaagag ccatgtgctg aggaggacag cgaggagaag     1140

gccgaacaga cgcccctgtc ccaggagagt gacgactatt cccaaccatc gacttccagc     1200

agcattgttt atagcagcca agaaagcgtg aaagagttga aggaggaaac gcagcacaaa     1260

gacgagagtg tggaatctag cttctccctg aatgccatcg aaccatgtgt gatctgccag     1320

gggcggccta aaaatggctg cattgttcac ggcaagactg gacacctcat gtcatgtttc     1380

acgtgtgcaa agaagctaaa aaaaagaaac aagccctgcc cagtgtgcag acagccaatc     1440

caaatgattg tgctaagtta cttcaactag                                      1470


<210>  73
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Nuclear translocation peptide

<400>  73

Pro Pro Lys Lys Lys Arg Lys Val 
1               5               


