                         SEQUENCE LISTING

<110>  The University of Kansas Medical Center
       Tufts Medical Center, Inc.
       Holyoak, Todd
       Qiu, Jiazhou
       Plaut, Andrew  G.
 
<120>  IgA1 protease polypeptide agents and uses thereof

<130>  2004117-0062 (TMC398)

<150>  61/170,935
<151>  2009-04-20

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  5657
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(5657)
<223>  encodes IgA1 protease (See GenBank entry X59800)

<400>  1
tttttaaaaa ttattatcat tacctcataa atgtaattca agttttgagc gatttatgct       60

ataaagctcg ctcattataa agatgaagac aacttgcaaa ttatcaacgc aacacagcca      120

aaatttgaat caacttgtaa ccgtatatca aattgtgtcc tatcaaatct actttttaaa      180

cttaattaat aaggacagct tctatgctaa ataaaaaatt caaactcaat tttattgcgc      240

ttactgtcgc ctacgcatta accccttata cagaagctgc gttagtgaga gacgatgtgg      300

attatcaaat atttcgtgat tttgcagaaa ataaagggag attttctgtt ggtgcaacaa      360

atgtggaagt gagagataaa aataaccact ctttaggcaa tgttttacct aatggcattc      420

cgatgattga ttttagtgtt gtggatgtag ataaacgcat cgccacattg ataaatccac      480

aatatgtagt aggtgtaaaa cacgttagta acggcgtgag tgaactacat tttgggaact      540

taaatggcaa tatgaataat ggcaatgcta aatcgcaccg agatgtatct tcagaagaaa      600

atagatattt ttccgttgag aaaaatgagt atccaactaa attgaatgga aaagcagtaa      660

ctactgaaga tcaaactcaa aaacgccgtg aagactacta tatgccacgt cttgataaat      720

ttgttaccga agttgcacca atagaggctt caactgcaag tagtgatgct ggcacatata      780

atgatcagaa taaatatcct gcttttgtaa gactaggaag tggtagtcaa tttatttata      840

aaaaaggaga taattacagc ttaattttaa ataatcatga ggttggaggc aataatctta      900

aattggtggg cgatgcctat acctatggta ttgcaggcac accttataaa gtaaaccacg      960

gggttaatgg actaattggt tttggcaatt caaaagagga acacagcgat ccaaaagcca     1020

tattatctca agatccgctt accaattatg ctgttttagg cgacagtggc tccccattat     1080

ttgtatatga tagagaaaaa ggaaaatggc tttttcttgg gtcttatgat ttttgggcag     1140

gttataacaa aaaatcttgg caagaatgga atatttataa acctgaattt gcaaaaactg     1200

ttctagataa agatactgca ggttctttaa ctggttctaa cacccaatac aattggaatc     1260

ctactggcaa aacaagcgtt atttctaatg gttctgaatc tctaaatgtt gatttattcg     1320

atagtagtca ggatacggac tctaagaaga acaatcacgg aaaaagtgtg actcttagag     1380

gaagtggaac gcttacctta aataataata tcgatcaagg cgcaggcggc ttgttctttg     1440

aaggagatta tgaagttaaa ggcacttctg atagtaccac ttggaaagga gctggcgttt     1500

ctgttgctga tggaaaaaca gtaacgtgga aagtacataa cccgaaatct gatcgtttag     1560

ctaaaatcgg caaaggaaca ttaattgtag aagaaaaggg agaaaataaa ggttcgctaa     1620

aagtgggcga tggtactgtt atcttaaaac aacaagctga tgccaataat aaagttaaag     1680

ccttttcaca agtaggtata gtaagtggtc gctcaactgt tgtacttaat gatgataagc     1740

aagtagatcc aaattccatt tactttggct ttagaggtgg tcgattagat gccaatggca     1800

ataatctcac ttttgaacat atccgtaata ttgatgatgg cgcaagacta gtaaatcaca     1860

ataccagcaa aacctctact gtaacaatta ctggggaaag tctaattaca gatccaaata     1920

caattactcc atataatata gacgcaccag atgaagataa tccttatgcc tttcgacgga     1980

ttaaagatgg aggacagctc tatttaaatt tggaaaatta cacttattat gcgttaagaa     2040

aaggtgcgag cactcgttca gaattaccta aaaatagtgg cgaaagcaat gaaaattggc     2100

tatatatggg taaaacttcc gatgaagcca aaagaaatgt aatgaaccat atcaacaacg     2160

agcgtatgaa tggctttaac ggttattttg gcgaggaaga gggtaaaaat aacggtaatc     2220

taaatgtgac ttttaaaggc aaaagtgagc aaaatcgctt tttattaaca ggcggaacaa     2280

accttaatgg cgatttaaag gttgaaaaag gcacattatt cctttctggc agaccaacac     2340

cgcacgcaag agatattgca ggtatttctt cgacaaaaaa agatcaacac tttgctgaaa     2400

ataatgaagt ggtagtagaa gatgactgga ttaaccgcaa ttttaaagca acaaatatta     2460

atgtaaccaa taacgcaacc ctttattcag gtcgcaatgt tgcaaacatt acttcaaata     2520

tcacagcttc tgataatgca aaagtacata ttggctataa agcaggcgat accgtttgtg     2580

tacgttctga ctatacgggc tatgtgactt gcactactga caagttatcc gataaagccc     2640

ttaatagctt taacgccacc aatgtatctg gcaatgtaaa tttatcaggt aatgcaaact     2700

ttgtcttagg caaagctaac ttattcggca caattagcgg cacgggaaat agccaagtac     2760

gtttaaccga aaatagccat tggcatttaa caggcgatac gaatgttaat cagttaaatt     2820

tagacaaggg gcatattcat ttaaatgcac aaaacgatgc aaataaagta actacatata     2880

acacgctgac tgtgaatagc ttatcaggta acggttcttt ctattattta actgatcttt     2940

ccaataaaca aggcgacaaa gttgttgtaa ctaaatccgc cacaggtaac tttacattac     3000

aagtggcaga taaaacaggc gagcctacaa aaaatgaact cacgcttttt gatgcgtcaa     3060

atgctacaag aaataatttg aatgtgtcat tagttgggaa taccgttgat ttaggtgctt     3120

ggaaatataa attacgtaat gttaatggac gttacgattt gtataaccca gaggtggaaa     3180

aaagaaatca aactgtcgat acgacaaata tcacaacacc taataatatt caagctgatg     3240

tgcctagcgt accaagtaac aatgaagaaa tagcccgtgt tgaaacacca gttccaccac     3300

ctgcgcctga tacaccatca gagacaactg aaacagtggc tgaaaatagt aagcaagaaa     3360

gtaaaacagt agagaaaaac gagcaagacg caaccgagac aacagctcaa aatggagaag     3420

ttggagaaga agctaaacca agtgtaaaag ctaatactca aacaaatgaa gtggctcaaa     3480

gtggaagtga aaccgaggaa actcaaacga ctgaaataaa agaaacagct aaagtagaaa     3540

aagaggaaaa ggctaaagta gaaaaagatg aaattcaaga agcacctcaa atggcttctg     3600

aaacgtctcc gaaacaagca aagcctgctc ctaaagaagt ttcaactgat acgaaagtag     3660

aagaaactca agttcaagct caaccgcaaa cacaatcgac aactgttgct gcggcagagg     3720

caacttcgcc aaacagtaaa ccagcggaag aaactcaacc aagtgaaaaa actaacgctg     3780

aacctgtaac gcctgtagta tcaaaaaatc aaacagaaaa tacgaccgac caaccaacag     3840

aaagagagaa aacggctaaa gtagaaacag agaaaactca agaaccccct caagtggctt     3900

ctcaagcgtc tccgaaacag gaacagtctg aaactgttca accgcaagca gtgcttgaaa     3960

gtgaaaatgt tccgactgtt aataatgcag aagaagttca agctcaactg caaacacaaa     4020

caagtgcaac agtaagcact aaacaacctg caccagagaa ttcaataaat actggatctg     4080

caaccgcaat aacagaaact gctgaaaaat ccgataaacc acaaacggaa actgcggctt     4140

cgactgaaga tgctagtcag cataaagcga atactgttgc ggataattct gtagcaaata     4200

attcagaaag cagtgatcca aagagtagac gtagaagaag tattagccag ccgcaagaga     4260

cttctgctga agaaacaaca gcagcttcta ctgacgaaac aacaatagct gataattcaa     4320

aacgcagtaa gccaaatcgt agaagtagaa gaagtgttcg ctcggaacca actgttacaa     4380

atggcagcga tcgttctaca gtagcattgc gcgatctcac aagtacaaac acaaatgcgg     4440

taatttctga tgcaatggca aaaggacaat ttgttgcatt aaatgtgggg aaagcagttt     4500

ctcaacatat tagccagtta gaaatgaata acgaggggca atataacgtt tgggtatcta     4560

atacttcaat gaacgaaaat tattcctcaa gtcaatatcg tcgttttagt tctaaaagta     4620

cgcaaactca acttggttgg gatcaaacaa tctcaaacaa tgttcagtta ggtggcgtgt     4680

ttacttatgt tcgcaatagt aacaactttg ataaggcaag cagtaaaaat actctagcac     4740

aagttaattt ctattctaaa tattatgcgg ataatcattg gtatttgggc attgatttag     4800

gctacggcaa gttccaaagc aacctaaaaa ccaatactaa tgcgaaattt gctcgccata     4860

ctgcacaatt tggtttaacc gcaggcaaag catttaatct tggcaatttt ggtattacgc     4920

caatagtagg cgtgcgttat agctatttat caaacgctaa ttttgcatta gctaaagatc     4980

gcattaaagt aaatccaata tctgtcaaaa cagcctttgc tcaagttgat ttaagttata     5040

cttatcactt aggcgagttt tccgttacgc caattttgtc tgctcgatat gatacaaatc     5100

aaggcagcgg aaaaattaat gtaaatcaat atgattttgc ttacaacgtg gaaaaccaac     5160

agcaatataa cgcagggctt aaattgaaat atcataatgt gaaattaagt ctaataggcg     5220

gattaacaaa agcgaaacaa gcggaaaaac aaaaaactgc agaattaaaa ctaagtttta     5280

gtttttaata agcctgtttg aattaacgtt ataaacaaca aagccctgtg tcttacaggg     5340

ctttattttt gaatgaaatt cagtgattaa gtgcggtgaa aaatcagcgc attttttatt     5400

tttaacgtaa aaacgctgga atatttttct cgtatgctga gattttgtct tcgtgctgaa     5460

gagttaagcc gatattatct aaaccgttta gcaaacaatg gcggcggaat tcatcaagct     5520

caaaagtata aactttatcc cctacagtga ccgagatcgc ttctaaatct acgtggattt     5580

gtttgccttc atttgcccat acccattgga agatttcttc tacttcttct tcgcttaaac     5640

gaatcggtaa catatgc                                                    5657


<210>  2
<211>  1694
<212>  PRT
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(1694)
<223>  full-length precursor IgA1 protease (See GenBank entry X59800)

<400>  2

Met Leu Asn Lys Lys Phe Lys Leu Asn Phe Ile Ala Leu Thr Val Ala 
1               5                   10                  15      


Tyr Ala Leu Thr Pro Tyr Thr Glu Ala Ala Leu Val Arg Asp Asp Val 
            20                  25                  30          


Asp Tyr Gln Ile Phe Arg Asp Phe Ala Glu Asn Lys Gly Arg Phe Ser 
        35                  40                  45              


Val Gly Ala Thr Asn Val Glu Val Arg Asp Lys Asn Asn His Ser Leu 
    50                  55                  60                  


Gly Asn Val Leu Pro Asn Gly Ile Pro Met Ile Asp Phe Ser Val Val 
65                  70                  75                  80  


Asp Val Asp Lys Arg Ile Ala Thr Leu Ile Asn Pro Gln Tyr Val Val 
                85                  90                  95      


Gly Val Lys His Val Ser Asn Gly Val Ser Glu Leu His Phe Gly Asn 
            100                 105                 110         


Leu Asn Gly Asn Met Asn Asn Gly Asn Ala Lys Ser His Arg Asp Val 
        115                 120                 125             


Ser Ser Glu Glu Asn Arg Tyr Phe Ser Val Glu Lys Asn Glu Tyr Pro 
    130                 135                 140                 


Thr Lys Leu Asn Gly Lys Ala Val Thr Thr Glu Asp Gln Thr Gln Lys 
145                 150                 155                 160 


Arg Arg Glu Asp Tyr Tyr Met Pro Arg Leu Asp Lys Phe Val Thr Glu 
                165                 170                 175     


Val Ala Pro Ile Glu Ala Ser Thr Ala Ser Ser Asp Ala Gly Thr Tyr 
            180                 185                 190         


Asn Asp Gln Asn Lys Tyr Pro Ala Phe Val Arg Leu Gly Ser Gly Ser 
        195                 200                 205             


Gln Phe Ile Tyr Lys Lys Gly Asp Asn Tyr Ser Leu Ile Leu Asn Asn 
    210                 215                 220                 


His Glu Val Gly Gly Asn Asn Leu Lys Leu Val Gly Asp Ala Tyr Thr 
225                 230                 235                 240 


Tyr Gly Ile Ala Gly Thr Pro Tyr Lys Val Asn His Gly Val Asn Gly 
                245                 250                 255     


Leu Ile Gly Phe Gly Asn Ser Lys Glu Glu His Ser Asp Pro Lys Ala 
            260                 265                 270         


Ile Leu Ser Gln Asp Pro Leu Thr Asn Tyr Ala Val Leu Gly Asp Ser 
        275                 280                 285             


Gly Ser Pro Leu Phe Val Tyr Asp Arg Glu Lys Gly Lys Trp Leu Phe 
    290                 295                 300                 


Leu Gly Ser Tyr Asp Phe Trp Ala Gly Tyr Asn Lys Lys Ser Trp Gln 
305                 310                 315                 320 


Glu Trp Asn Ile Tyr Lys Pro Glu Phe Ala Lys Thr Val Leu Asp Lys 
                325                 330                 335     


Asp Thr Ala Gly Ser Leu Thr Gly Ser Asn Thr Gln Tyr Asn Trp Asn 
            340                 345                 350         


Pro Thr Gly Lys Thr Ser Val Ile Ser Asn Gly Ser Glu Ser Leu Asn 
        355                 360                 365             


Val Asp Leu Phe Asp Ser Ser Gln Asp Thr Asp Ser Lys Lys Asn Asn 
    370                 375                 380                 


His Gly Lys Ser Val Thr Leu Arg Gly Ser Gly Thr Leu Thr Leu Asn 
385                 390                 395                 400 


Asn Asn Ile Asp Gln Gly Ala Gly Gly Leu Phe Phe Glu Gly Asp Tyr 
                405                 410                 415     


Glu Val Lys Gly Thr Ser Asp Ser Thr Thr Trp Lys Gly Ala Gly Val 
            420                 425                 430         


Ser Val Ala Asp Gly Lys Thr Val Thr Trp Lys Val His Asn Pro Lys 
        435                 440                 445             


Ser Asp Arg Leu Ala Lys Ile Gly Lys Gly Thr Leu Ile Val Glu Glu 
    450                 455                 460                 


Lys Gly Glu Asn Lys Gly Ser Leu Lys Val Gly Asp Gly Thr Val Ile 
465                 470                 475                 480 


Leu Lys Gln Gln Ala Asp Ala Asn Asn Lys Val Lys Ala Phe Ser Gln 
                485                 490                 495     


Val Gly Ile Val Ser Gly Arg Ser Thr Val Val Leu Asn Asp Asp Lys 
            500                 505                 510         


Gln Val Asp Pro Asn Ser Ile Tyr Phe Gly Phe Arg Gly Gly Arg Leu 
        515                 520                 525             


Asp Ala Asn Gly Asn Asn Leu Thr Phe Glu His Ile Arg Asn Ile Asp 
    530                 535                 540                 


Asp Gly Ala Arg Leu Val Asn His Asn Thr Ser Lys Thr Ser Thr Val 
545                 550                 555                 560 


Thr Ile Thr Gly Glu Ser Leu Ile Thr Asp Pro Asn Thr Ile Thr Pro 
                565                 570                 575     


Tyr Asn Ile Asp Ala Pro Asp Glu Asp Asn Pro Tyr Ala Phe Arg Arg 
            580                 585                 590         


Ile Lys Asp Gly Gly Gln Leu Tyr Leu Asn Leu Glu Asn Tyr Thr Tyr 
        595                 600                 605             


Tyr Ala Leu Arg Lys Gly Ala Ser Thr Arg Ser Glu Leu Pro Lys Asn 
    610                 615                 620                 


Ser Gly Glu Ser Asn Glu Asn Trp Leu Tyr Met Gly Lys Thr Ser Asp 
625                 630                 635                 640 


Glu Ala Lys Arg Asn Val Met Asn His Ile Asn Asn Glu Arg Met Asn 
                645                 650                 655     


Gly Phe Asn Gly Tyr Phe Gly Glu Glu Glu Gly Lys Asn Asn Gly Asn 
            660                 665                 670         


Leu Asn Val Thr Phe Lys Gly Lys Ser Glu Gln Asn Arg Phe Leu Leu 
        675                 680                 685             


Thr Gly Gly Thr Asn Leu Asn Gly Asp Leu Lys Val Glu Lys Gly Thr 
    690                 695                 700                 


Leu Phe Leu Ser Gly Arg Pro Thr Pro His Ala Arg Asp Ile Ala Gly 
705                 710                 715                 720 


Ile Ser Ser Thr Lys Lys Asp Gln His Phe Ala Glu Asn Asn Glu Val 
                725                 730                 735     


Val Val Glu Asp Asp Trp Ile Asn Arg Asn Phe Lys Ala Thr Asn Ile 
            740                 745                 750         


Asn Val Thr Asn Asn Ala Thr Leu Tyr Ser Gly Arg Asn Val Ala Asn 
        755                 760                 765             


Ile Thr Ser Asn Ile Thr Ala Ser Asp Asn Ala Lys Val His Ile Gly 
    770                 775                 780                 


Tyr Lys Ala Gly Asp Thr Val Cys Val Arg Ser Asp Tyr Thr Gly Tyr 
785                 790                 795                 800 


Val Thr Cys Thr Thr Asp Lys Leu Ser Asp Lys Ala Leu Asn Ser Phe 
                805                 810                 815     


Asn Ala Thr Asn Val Ser Gly Asn Val Asn Leu Ser Gly Asn Ala Asn 
            820                 825                 830         


Phe Val Leu Gly Lys Ala Asn Leu Phe Gly Thr Ile Ser Gly Thr Gly 
        835                 840                 845             


Asn Ser Gln Val Arg Leu Thr Glu Asn Ser His Trp His Leu Thr Gly 
    850                 855                 860                 


Asp Thr Asn Val Asn Gln Leu Asn Leu Asp Lys Gly His Ile His Leu 
865                 870                 875                 880 


Asn Ala Gln Asn Asp Ala Asn Lys Val Thr Thr Tyr Asn Thr Leu Thr 
                885                 890                 895     


Val Asn Ser Leu Ser Gly Asn Gly Ser Phe Tyr Tyr Leu Thr Asp Leu 
            900                 905                 910         


Ser Asn Lys Gln Gly Asp Lys Val Val Val Thr Lys Ser Ala Thr Gly 
        915                 920                 925             


Asn Phe Thr Leu Gln Val Ala Asp Lys Thr Gly Glu Pro Thr Lys Asn 
    930                 935                 940                 


Glu Leu Thr Leu Phe Asp Ala Ser Asn Ala Thr Arg Asn Asn Leu Asn 
945                 950                 955                 960 


Val Ser Leu Val Gly Asn Thr Val Asp Leu Gly Ala Trp Lys Tyr Lys 
                965                 970                 975     


Leu Arg Asn Val Asn Gly Arg Tyr Asp Leu Tyr Asn Pro Glu Val Glu 
            980                 985                 990         


Lys Arg Asn Gln Thr Val Asp Thr  Thr Asn Ile Thr Thr  Pro Asn Asn 
        995                 1000                 1005             


Ile Gln  Ala Asp Val Pro Ser  Val Pro Ser Asn Asn  Glu Glu Ile 
    1010                 1015                 1020             


Ala Arg  Val Glu Thr Pro Val  Pro Pro Pro Ala Pro  Asp Thr Pro 
    1025                 1030                 1035             


Ser Glu  Thr Thr Glu Thr Val  Ala Glu Asn Ser Lys  Gln Glu Ser 
    1040                 1045                 1050             


Lys Thr  Val Glu Lys Asn Glu  Gln Asp Ala Thr Glu  Thr Thr Ala 
    1055                 1060                 1065             


Gln Asn  Gly Glu Val Gly Glu  Glu Ala Lys Pro Ser  Val Lys Ala 
    1070                 1075                 1080             


Asn Thr  Gln Thr Asn Glu Val  Ala Gln Ser Gly Ser  Glu Thr Glu 
    1085                 1090                 1095             


Glu Thr  Gln Thr Thr Glu Ile  Lys Glu Thr Ala Lys  Val Glu Lys 
    1100                 1105                 1110             


Glu Glu  Lys Ala Lys Val Glu  Lys Asp Glu Ile Gln  Glu Ala Pro 
    1115                 1120                 1125             


Gln Met  Ala Ser Glu Thr Ser  Pro Lys Gln Ala Lys  Pro Ala Pro 
    1130                 1135                 1140             


Lys Glu  Val Ser Thr Asp Thr  Lys Val Glu Glu Thr  Gln Val Gln 
    1145                 1150                 1155             


Ala Gln  Pro Gln Thr Gln Ser  Thr Thr Val Ala Ala  Ala Glu Ala 
    1160                 1165                 1170             


Thr Ser  Pro Asn Ser Lys Pro  Ala Glu Glu Thr Gln  Pro Ser Glu 
    1175                 1180                 1185             


Lys Thr  Asn Ala Glu Pro Val  Thr Pro Val Val Ser  Lys Asn Gln 
    1190                 1195                 1200             


Thr Glu  Asn Thr Thr Asp Gln  Pro Thr Glu Arg Glu  Lys Thr Ala 
    1205                 1210                 1215             


Lys Val  Glu Thr Glu Lys Thr  Gln Glu Pro Pro Gln  Val Ala Ser 
    1220                 1225                 1230             


Gln Ala  Ser Pro Lys Gln Glu  Gln Ser Glu Thr Val  Gln Pro Gln 
    1235                 1240                 1245             


Ala Val  Leu Glu Ser Glu Asn  Val Pro Thr Val Asn  Asn Ala Glu 
    1250                 1255                 1260             


Glu Val  Gln Ala Gln Leu Gln  Thr Gln Thr Ser Ala  Thr Val Ser 
    1265                 1270                 1275             


Thr Lys  Gln Pro Ala Pro Glu  Asn Ser Ile Asn Thr  Gly Ser Ala 
    1280                 1285                 1290             


Thr Ala  Ile Thr Glu Thr Ala  Glu Lys Ser Asp Lys  Pro Gln Thr 
    1295                 1300                 1305             


Glu Thr  Ala Ala Ser Thr Glu  Asp Ala Ser Gln His  Lys Ala Asn 
    1310                 1315                 1320             


Thr Val  Ala Asp Asn Ser Val  Ala Asn Asn Ser Glu  Ser Ser Asp 
    1325                 1330                 1335             


Pro Lys  Ser Arg Arg Arg Arg  Ser Ile Ser Gln Pro  Gln Glu Thr 
    1340                 1345                 1350             


Ser Ala  Glu Glu Thr Thr Ala  Ala Ser Thr Asp Glu  Thr Thr Ile 
    1355                 1360                 1365             


Ala Asp  Asn Ser Lys Arg Ser  Lys Pro Asn Arg Arg  Ser Arg Arg 
    1370                 1375                 1380             


Ser Val  Arg Ser Glu Pro Thr  Val Thr Asn Gly Ser  Asp Arg Ser 
    1385                 1390                 1395             


Thr Val  Ala Leu Arg Asp Leu  Thr Ser Thr Asn Thr  Asn Ala Val 
    1400                 1405                 1410             


Ile Ser  Asp Ala Met Ala Lys  Gly Gln Phe Val Ala  Leu Asn Val 
    1415                 1420                 1425             


Gly Lys  Ala Val Ser Gln His  Ile Ser Gln Leu Glu  Met Asn Asn 
    1430                 1435                 1440             


Glu Gly  Gln Tyr Asn Val Trp  Val Ser Asn Thr Ser  Met Asn Glu 
    1445                 1450                 1455             


Asn Tyr  Ser Ser Ser Gln Tyr  Arg Arg Phe Ser Ser  Lys Ser Thr 
    1460                 1465                 1470             


Gln Thr  Gln Leu Gly Trp Asp  Gln Thr Ile Ser Asn  Asn Val Gln 
    1475                 1480                 1485             


Leu Gly  Gly Val Phe Thr Tyr  Val Arg Asn Ser Asn  Asn Phe Asp 
    1490                 1495                 1500             


Lys Ala  Ser Ser Lys Asn Thr  Leu Ala Gln Val Asn  Phe Tyr Ser 
    1505                 1510                 1515             


Lys Tyr  Tyr Ala Asp Asn His  Trp Tyr Leu Gly Ile  Asp Leu Gly 
    1520                 1525                 1530             


Tyr Gly  Lys Phe Gln Ser Asn  Leu Lys Thr Asn Thr  Asn Ala Lys 
    1535                 1540                 1545             


Phe Ala  Arg His Thr Ala Gln  Phe Gly Leu Thr Ala  Gly Lys Ala 
    1550                 1555                 1560             


Phe Asn  Leu Gly Asn Phe Gly  Ile Thr Pro Ile Val  Gly Val Arg 
    1565                 1570                 1575             


Tyr Ser  Tyr Leu Ser Asn Ala  Asn Phe Ala Leu Ala  Lys Asp Arg 
    1580                 1585                 1590             


Ile Lys  Val Asn Pro Ile Ser  Val Lys Thr Ala Phe  Ala Gln Val 
    1595                 1600                 1605             


Asp Leu  Ser Tyr Thr Tyr His  Leu Gly Glu Phe Ser  Val Thr Pro 
    1610                 1615                 1620             


Ile Leu  Ser Ala Arg Tyr Asp  Thr Asn Gln Gly Ser  Gly Lys Ile 
    1625                 1630                 1635             


Asn Val  Asn Gln Tyr Asp Phe  Ala Tyr Asn Val Glu  Asn Gln Gln 
    1640                 1645                 1650             


Gln Tyr  Asn Ala Gly Leu Lys  Leu Lys Tyr His Asn  Val Lys Leu 
    1655                 1660                 1665             


Ser Leu  Ile Gly Gly Leu Thr  Lys Ala Lys Gln Ala  Glu Lys Gln 
    1670                 1675                 1680             


Lys Thr  Ala Glu Leu Lys Leu  Ser Phe Ser Phe 
    1685                 1690                 


<210>  3
<211>  5096
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(5096)
<223>  encodes IgA1 protease (See GenBank entry X64357)

<400>  3
catcattacg ccttaaatta accaaaagtg cggtaaaaaa tagccaattt tttaaaaaat       60

atcaaaaatc attatcatta cctcgtaaat gtaattcaag ttttgagcga tttatgctat      120

aaaacccact cattataaaa atgaagacaa cttgcaaact atcaatgcaa cacagccaag      180

atttgaatca acttgtagcc gtatatcaaa ttgtgtccta tcaaatctac tttttaaact      240

taattaataa agacagcttc tatgctaaat aaaaaattca aactcaattt tattgcactt      300

actgtcgcct acgcattaac cccttataca gaagccgcgt tagtgagaga cgatgtggat      360

tatcaaatat tccgtgattt tgcagagaat aaagggaagt tttctgttgg tgcaacaaat      420

gtgctggtaa aggataaaaa taataaagat ttgggcactg ccttacctaa cggtattccg      480

atgattgatt ttagcgtggt agatgtagat aaacgcattg ccacattgat aaatccacaa      540

tatgtagtag gtgtaaaaca cgttagtaac ggcgtgagtg aactacattt tggtaactta      600

aacggcaata tgaataatgg caatgccaag gcacaccgag atgtatcttc agaagaaaat      660

agatattttt ccgttgagaa aaatgagtat ccaactaaat tgaatggaaa aacagtaact      720

acggaagatc aaactcaaaa acgccgtgaa gactactata tgccacgtct tgataaattt      780

gttacggaag ttgcaccaat agaggcttca accgcaagta gtgatgctgg cacatataat      840

gatcagaata aatatcctgc ttttgtaaga ctaggaagtg gtagtcaatt tatttataaa      900

aaaggagata attacagctt aattttaaat aatcatgagg ttggaggcaa taatcttaaa      960

ttggtgggcg atgcctatac ctatggtatt gcaggtacac cttataaagt aaaccacgag     1020

aataatggac taattggttt tggcaattca aaagaggaac acagcgatcc aaaaggaata     1080

ttatctcaag atcctcttac caattatgct gttttaggcg acagtggctc cccattattt     1140

gtatatgata gagaaaaagg aaaatggctt tttcttgggt cttatgattt ttgggcgggt     1200

tataacaaaa aatcttggca agaatggaat atttataaat ctcaatttac taaagatgtt     1260

ctcaataaag atagtgcagg ttctttaatt ggttccaaga cagattatag ttggtcttct     1320

aatggcaaga caagtacgat tacgggaggg gagaaatctt taaatgttga tttagctgac     1380

ggaaaagata aacctaatca cgggaaaagt gttacatttg aagggagtgg aacgcttacc     1440

ttaaataata atatcgatca aggtgcaggc ggattattct ttgaaggcga ttatgaagtt     1500

aaaggtactt ctgataatac tacttggaaa ggagcaggtg tctctgttgc cgaaggaaaa     1560

actgtaacgt ggaaagtgca taatcctcaa tatgatcgtt tagcaaaaat tggcaaaggg     1620

acattaattg ttgaaggaac aggagataat aaaggttcgc taaaagtggg cgatggcacc     1680

gttattttaa aacaacaaac aaatggttcg ggacaacacg cttttgcttc tgtagggatt     1740

gtaagtggtc gctcaactct tgtgcttaat gatgataaac aagtagatcc aaattcaatt     1800

tactttggct ttagaggcgg tcgattagac ttaaacggta attcactaac ctttgatcac     1860

atcagaaata ttgatgatgg tgcaagacta gttaatcata atatgactaa tgcctcaaat     1920

ataacgatta ctggggaaag tctaattaca gatccaaata caattactcc atataatata     1980

gacgcaccag atgaagataa tccttatgcc tttcgacgga ttaaagatgg aggacagctc     2040

tatttaaatt tggaaaatta cacttattat gcgttaagaa aaggtgcgag cactcgttca     2100

gaattaccta aaaatagtgg cgaaagcaat gaaaattggc tatatatggg taaaacttcc     2160

gatgaagcca aaagaaatgt aatgaaccat atcaacaacg agcgtatgaa tggctttaat     2220

ggttattttg gcgaggaaga gggtaaaaat aacggtaatc taaatgtgac ttttaaaggc     2280

aaaagtgagc aaaatcgctt tttattaaca ggcggtacaa accttaatgg cgatttaacg     2340

gttgaaaaag gcaccttatt cctttcaggc agaccaacac cgcacgcaag agatattgca     2400

ggtatttctt cgacaaaaaa agatcctcac tttgctgaaa ataatgaagt ggtagtagaa     2460

gatgactgga ttaaccgcaa ttttaaagca accacaatga acgtgactgg caatgcctca     2520

ctttattcag gtcgcaatgt tgcaaacatt acgtcaaata tcacagcttc taataaagca     2580

caagttcata tcggctataa aacaggcgat accgtttgtg tacgttctga ctatacgggc     2640

tatgtgactt gtactactga caagttatcc gataaagccc ttaatagctt taatccaacc     2700

aatctacgcg gcaatgtaaa tttaaccgaa agtgcaaact ttgtcttagg caaagccaac     2760

ttattcggca caattcaaag cagaggaaat agccaagtac gtttaaccga aaatagccat     2820

tggcatttaa caggaaatag tgatgttcat caattagatc tagcaaatgg gcatattcat     2880

ttaaattcag cagacaattc aaacaatgtg acaaaatata acacgctgac tgtgaatagc     2940

ttatcaggta acggttcttt ctattattta actgatcttt ccaataaaca aggcgacaaa     3000

gttgttgtaa ctaaatccgc cacaggtaac tttacattac aagtggcaga taaaacaggc     3060

gagccaaatc ataatgaact cacacttttt gatgcttcaa aagctcaaag agatcatttg     3120

aatgtgtcat tagttgggaa taccgttgat ttaggtgctt ggaaatataa attacgtaat     3180

gttaatggac gttacgattt gtataaccca gaggtggaaa aaagaaatca aactgtcgat     3240

acgacaaata tcacaacacc taataatatt caagctgatg tgcctagcgt accaagtaac     3300

aatgaagaaa tagcccgtgt tgatgaagca ccagttccac cacctgcgcc tgctacacca     3360

tcagagacaa ctgaaacagt ggctgaaaat agtaagcaag aaagtaaaac agtagagaaa     3420

aacgagcaag acgcaaccga gacaacagct caaaatagag aagttgcaaa agaagctaaa     3480

tcaaatgtaa aagctaatac tcaaacaaat gaagtagctc aaagtggaag tgaaaccaag     3540

gaaactcaaa cgactgaaac aaaagaaaca gctacggtag aaaaagaaga aaaggctaaa     3600

gtagaaacag agaaaactca agaagtccct aaagtgactt ctcaagtgtc tccgaaacag     3660

gaacagtctg aaactgttca accgcaagca gagcctgctc gtgaaaatga tccgactgtt     3720

aatataaaag agcctcaatc tcaaacaaat acaacagcag acactgaaca acctgcgaaa     3780

gagactagct caaatgttga acaaccagtg acagaaagca caacagtaaa cactggaaac     3840

tctgtagtgg aaaatccaga gaatacaaca cctgctacaa ctcaacctac ggttaattca     3900

gaaagcagta ataagccaaa gaatagacat agaagaagtg ttcgctcagt tccgcataat     3960

gttgaaccag ctacaacaag tagcaacgat cgttctacag tagcattgtg cgatctcaca     4020

agtacaaaca caaatgcggt actttctgat gcaagggcaa aagcacaatt tgttgcatta     4080

aatgtgggga aagcagtttc tcaacatatt agccagttag aaatgaataa cgaggggcaa     4140

tataacgttt gggtatctaa tacttcaatg aacaaaaatt attcctcaag tcaatatcgt     4200

cgttttagtt ctaaaagtac gcaaactcaa ctgggttggg atcaaacaat ctcaaacaat     4260

gttcagttag gtggcgtgtt tacttatgtt cgcaatagta acaactttga taaggcaaca     4320

agtaaaaata ctctagcaca agttaatttc tattctaaat attatgcgga taatcattgg     4380

tatttgggca ttgatttagg ctacggcaag ttccaaagca aattacaaac taatcataat     4440

gcgaaatttg ctcgccatac tgcacaattt ggtttaaccg caggcaaagc atttaatctt     4500

ggcaattttg gtattacgcc aatagtaggc gtgcgttata gctatttatc aaacgctgat     4560

tttgcattag atcaagctcg cattaaagta aatccaatat ctgtcaaaac agcctttgct     4620

caagttgatt taagttatac ttatcactta ggcgagtttt ccgttacgcc aattttgtct     4680

gctcgatatg atgcaaacca aggcagcgga aaaattaatg taaatggata tgattttgct     4740

tacaacgtgg aaaaccaaca gcaatataac gcagggctta aattgaaata tcataatgtg     4800

aaattaagtc taataggcgg attaacaaaa gcgaaacaag cggaaaaaca aaaaactgca     4860

gaattaaaac taagttttag tttttaataa gcctgtttga attaacgtta taaacaacaa     4920

agccctgtgt attacagggc tttatttttg aatgaaattc agtgattaag tgcggtgaaa     4980

aatcagcgca ttttttattt ttaacgtaaa aacgctggaa tatttttctc atatgctgag     5040

attttgtctt cgtgctgaag ggttaaaccg atattatcta aaccgtttag caaaca         5096


<210>  4
<211>  1541
<212>  PRT
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(1541)
<223>  full-length precursor IgA1 protease (See GenBank entry X64357)

<400>  4

Met Leu Asn Lys Lys Phe Lys Leu Asn Phe Ile Ala Leu Thr Val Ala 
1               5                   10                  15      


Tyr Ala Leu Thr Pro Tyr Thr Glu Ala Ala Leu Val Arg Asp Asp Val 
            20                  25                  30          


Asp Tyr Gln Ile Phe Arg Asp Phe Ala Glu Asn Lys Gly Lys Phe Ser 
        35                  40                  45              


Val Gly Ala Thr Asn Val Leu Val Lys Asp Lys Asn Asn Lys Asp Leu 
    50                  55                  60                  


Gly Thr Ala Leu Pro Asn Gly Ile Pro Met Ile Asp Phe Ser Val Val 
65                  70                  75                  80  


Asp Val Asp Lys Arg Ile Ala Thr Leu Ile Asn Pro Gln Tyr Val Val 
                85                  90                  95      


Gly Val Lys His Val Ser Asn Gly Val Ser Glu Leu His Phe Gly Asn 
            100                 105                 110         


Leu Asn Gly Asn Met Asn Asn Gly Asn Ala Lys Ala His Arg Asp Val 
        115                 120                 125             


Ser Ser Glu Glu Asn Arg Tyr Phe Ser Val Glu Lys Asn Glu Tyr Pro 
    130                 135                 140                 


Thr Lys Leu Asn Gly Lys Thr Val Thr Thr Glu Asp Gln Thr Gln Lys 
145                 150                 155                 160 


Arg Arg Glu Asp Tyr Tyr Met Pro Arg Leu Asp Lys Phe Val Thr Glu 
                165                 170                 175     


Val Ala Pro Ile Glu Ala Ser Thr Ala Ser Ser Asp Ala Gly Thr Tyr 
            180                 185                 190         


Asn Asp Gln Asn Lys Tyr Pro Ala Phe Val Arg Leu Gly Ser Gly Ser 
        195                 200                 205             


Gln Phe Ile Tyr Lys Lys Gly Asp Asn Tyr Ser Leu Ile Leu Asn Asn 
    210                 215                 220                 


His Glu Val Gly Gly Asn Asn Leu Lys Leu Val Gly Asp Ala Tyr Thr 
225                 230                 235                 240 


Tyr Gly Ile Ala Gly Thr Pro Tyr Lys Val Asn His Glu Asn Asn Gly 
                245                 250                 255     


Leu Ile Gly Phe Gly Asn Ser Lys Glu Glu His Ser Asp Pro Lys Gly 
            260                 265                 270         


Ile Leu Ser Gln Asp Pro Leu Thr Asn Tyr Ala Val Leu Gly Asp Ser 
        275                 280                 285             


Gly Ser Pro Leu Phe Val Tyr Asp Arg Glu Lys Gly Lys Trp Leu Phe 
    290                 295                 300                 


Leu Gly Ser Tyr Asp Phe Trp Ala Gly Tyr Asn Lys Lys Ser Trp Gln 
305                 310                 315                 320 


Glu Trp Asn Ile Tyr Lys Ser Gln Phe Thr Lys Asp Val Leu Asn Lys 
                325                 330                 335     


Asp Ser Ala Gly Ser Leu Ile Gly Ser Lys Thr Asp Tyr Ser Trp Ser 
            340                 345                 350         


Ser Asn Gly Lys Thr Ser Thr Ile Thr Gly Gly Glu Lys Ser Leu Asn 
        355                 360                 365             


Val Asp Leu Ala Asp Gly Lys Asp Lys Pro Asn His Gly Lys Ser Val 
    370                 375                 380                 


Thr Phe Glu Gly Ser Gly Thr Leu Thr Leu Asn Asn Asn Ile Asp Gln 
385                 390                 395                 400 


Gly Ala Gly Gly Leu Phe Phe Glu Gly Asp Tyr Glu Val Lys Gly Thr 
                405                 410                 415     


Ser Asp Asn Thr Thr Trp Lys Gly Ala Gly Val Ser Val Ala Glu Gly 
            420                 425                 430         


Lys Thr Val Thr Trp Lys Val His Asn Pro Gln Tyr Asp Arg Leu Ala 
        435                 440                 445             


Lys Ile Gly Lys Gly Thr Leu Ile Val Glu Gly Thr Gly Asp Asn Lys 
    450                 455                 460                 


Gly Ser Leu Lys Val Gly Asp Gly Thr Val Ile Leu Lys Gln Gln Thr 
465                 470                 475                 480 


Asn Gly Ser Gly Gln His Ala Phe Ala Ser Val Gly Ile Val Ser Gly 
                485                 490                 495     


Arg Ser Thr Leu Val Leu Asn Asp Asp Lys Gln Val Asp Pro Asn Ser 
            500                 505                 510         


Ile Tyr Phe Gly Phe Arg Gly Gly Arg Leu Asp Leu Asn Gly Asn Ser 
        515                 520                 525             


Leu Thr Phe Asp His Ile Arg Asn Ile Asp Asp Gly Ala Arg Leu Val 
    530                 535                 540                 


Asn His Asn Met Thr Asn Ala Ser Asn Ile Thr Ile Thr Gly Glu Ser 
545                 550                 555                 560 


Leu Ile Thr Asp Pro Asn Thr Ile Thr Pro Tyr Asn Ile Asp Ala Pro 
                565                 570                 575     


Asp Glu Asp Asn Pro Tyr Ala Phe Arg Arg Ile Lys Asp Gly Gly Gln 
            580                 585                 590         


Leu Tyr Leu Asn Leu Glu Asn Tyr Thr Tyr Tyr Ala Leu Arg Lys Gly 
        595                 600                 605             


Ala Ser Thr Arg Ser Glu Leu Pro Lys Asn Ser Gly Glu Ser Asn Glu 
    610                 615                 620                 


Asn Trp Leu Tyr Met Gly Lys Thr Ser Asp Glu Ala Lys Arg Asn Val 
625                 630                 635                 640 


Met Asn His Ile Asn Asn Glu Arg Met Asn Gly Phe Asn Gly Tyr Phe 
                645                 650                 655     


Gly Glu Glu Glu Gly Lys Asn Asn Gly Asn Leu Asn Val Thr Phe Lys 
            660                 665                 670         


Gly Lys Ser Glu Gln Asn Arg Phe Leu Leu Thr Gly Gly Thr Asn Leu 
        675                 680                 685             


Asn Gly Asp Leu Thr Val Glu Lys Gly Thr Leu Phe Leu Ser Gly Arg 
    690                 695                 700                 


Pro Thr Pro His Ala Arg Asp Ile Ala Gly Ile Ser Ser Thr Lys Lys 
705                 710                 715                 720 


Asp Pro His Phe Ala Glu Asn Asn Glu Val Val Val Glu Asp Asp Trp 
                725                 730                 735     


Ile Asn Arg Asn Phe Lys Ala Thr Thr Met Asn Val Thr Gly Asn Ala 
            740                 745                 750         


Ser Leu Tyr Ser Gly Arg Asn Val Ala Asn Ile Thr Ser Asn Ile Thr 
        755                 760                 765             


Ala Ser Asn Lys Ala Gln Val His Ile Gly Tyr Lys Thr Gly Asp Thr 
    770                 775                 780                 


Val Cys Val Arg Ser Asp Tyr Thr Gly Tyr Val Thr Cys Thr Thr Asp 
785                 790                 795                 800 


Lys Leu Ser Asp Lys Ala Leu Asn Ser Phe Asn Pro Thr Asn Leu Arg 
                805                 810                 815     


Gly Asn Val Asn Leu Thr Glu Ser Ala Asn Phe Val Leu Gly Lys Ala 
            820                 825                 830         


Asn Leu Phe Gly Thr Ile Gln Ser Arg Gly Asn Ser Gln Val Arg Leu 
        835                 840                 845             


Thr Glu Asn Ser His Trp His Leu Thr Gly Asn Ser Asp Val His Gln 
    850                 855                 860                 


Leu Asp Leu Ala Asn Gly His Ile His Leu Asn Ser Ala Asp Asn Ser 
865                 870                 875                 880 


Asn Asn Val Thr Lys Tyr Asn Thr Leu Thr Val Asn Ser Leu Ser Gly 
                885                 890                 895     


Asn Gly Ser Phe Tyr Tyr Leu Thr Asp Leu Ser Asn Lys Gln Gly Asp 
            900                 905                 910         


Lys Val Val Val Thr Lys Ser Ala Thr Gly Asn Phe Thr Leu Gln Val 
        915                 920                 925             


Ala Asp Lys Thr Gly Glu Pro Asn His Asn Glu Leu Thr Leu Phe Asp 
    930                 935                 940                 


Ala Ser Lys Ala Gln Arg Asp His Leu Asn Val Ser Leu Val Gly Asn 
945                 950                 955                 960 


Thr Val Asp Leu Gly Ala Trp Lys Tyr Lys Leu Arg Asn Val Asn Gly 
                965                 970                 975     


Arg Tyr Asp Leu Tyr Asn Pro Glu Val Glu Lys Arg Asn Gln Thr Val 
            980                 985                 990         


Asp Thr Thr Asn Ile Thr Thr Pro  Asn Asn Ile Gln Ala  Asp Val Pro 
        995                 1000                 1005             


Ser Val  Pro Ser Asn Asn Glu  Glu Ile Ala Arg Val  Asp Glu Ala 
    1010                 1015                 1020             


Pro Val  Pro Pro Pro Ala Pro  Ala Thr Pro Ser Glu  Thr Thr Glu 
    1025                 1030                 1035             


Thr Val  Ala Glu Asn Ser Lys  Gln Glu Ser Lys Thr  Val Glu Lys 
    1040                 1045                 1050             


Asn Glu  Gln Asp Ala Thr Glu  Thr Thr Ala Gln Asn  Arg Glu Val 
    1055                 1060                 1065             


Ala Lys  Glu Ala Lys Ser Asn  Val Lys Ala Asn Thr  Gln Thr Asn 
    1070                 1075                 1080             


Glu Val  Ala Gln Ser Gly Ser  Glu Thr Lys Glu Thr  Gln Thr Thr 
    1085                 1090                 1095             


Glu Thr  Lys Glu Thr Ala Thr  Val Glu Lys Glu Glu  Lys Ala Lys 
    1100                 1105                 1110             


Val Glu  Thr Glu Lys Thr Gln  Glu Val Pro Lys Val  Thr Ser Gln 
    1115                 1120                 1125             


Val Ser  Pro Lys Gln Glu Gln  Ser Glu Thr Val Gln  Pro Gln Ala 
    1130                 1135                 1140             


Glu Pro  Ala Arg Glu Asn Asp  Pro Thr Val Asn Ile  Lys Glu Pro 
    1145                 1150                 1155             


Gln Ser  Gln Thr Asn Thr Thr  Ala Asp Thr Glu Gln  Pro Ala Lys 
    1160                 1165                 1170             


Glu Thr  Ser Ser Asn Val Glu  Gln Pro Val Thr Glu  Ser Thr Thr 
    1175                 1180                 1185             


Val Asn  Thr Gly Asn Ser Val  Val Glu Asn Pro Glu  Asn Thr Thr 
    1190                 1195                 1200             


Pro Ala  Thr Thr Gln Pro Thr  Val Asn Ser Glu Ser  Ser Asn Lys 
    1205                 1210                 1215             


Pro Lys  Asn Arg His Arg Arg  Ser Val Arg Ser Val  Pro His Asn 
    1220                 1225                 1230             


Val Glu  Pro Ala Thr Thr Ser  Ser Asn Asp Arg Ser  Thr Val Ala 
    1235                 1240                 1245             


Leu Cys  Asp Leu Thr Ser Thr  Asn Thr Asn Ala Val  Leu Ser Asp 
    1250                 1255                 1260             


Ala Arg  Ala Lys Ala Gln Phe  Val Ala Leu Asn Val  Gly Lys Ala 
    1265                 1270                 1275             


Val Ser  Gln His Ile Ser Gln  Leu Glu Met Asn Asn  Glu Gly Gln 
    1280                 1285                 1290             


Tyr Asn  Val Trp Val Ser Asn  Thr Ser Met Asn Lys  Asn Tyr Ser 
    1295                 1300                 1305             


Ser Ser  Gln Tyr Arg Arg Phe  Ser Ser Lys Ser Thr  Gln Thr Gln 
    1310                 1315                 1320             


Leu Gly  Trp Asp Gln Thr Ile  Ser Asn Asn Val Gln  Leu Gly Gly 
    1325                 1330                 1335             


Val Phe  Thr Tyr Val Arg Asn  Ser Asn Asn Phe Asp  Lys Ala Thr 
    1340                 1345                 1350             


Ser Lys  Asn Thr Leu Ala Gln  Val Asn Phe Tyr Ser  Lys Tyr Tyr 
    1355                 1360                 1365             


Ala Asp  Asn His Trp Tyr Leu  Gly Ile Asp Leu Gly  Tyr Gly Lys 
    1370                 1375                 1380             


Phe Gln  Ser Lys Leu Gln Thr  Asn His Asn Ala Lys  Phe Ala Arg 
    1385                 1390                 1395             


His Thr  Ala Gln Phe Gly Leu  Thr Ala Gly Lys Ala  Phe Asn Leu 
    1400                 1405                 1410             


Gly Asn  Phe Gly Ile Thr Pro  Ile Val Gly Val Arg  Tyr Ser Tyr 
    1415                 1420                 1425             


Leu Ser  Asn Ala Asp Phe Ala  Leu Asp Gln Ala Arg  Ile Lys Val 
    1430                 1435                 1440             


Asn Pro  Ile Ser Val Lys Thr  Ala Phe Ala Gln Val  Asp Leu Ser 
    1445                 1450                 1455             


Tyr Thr  Tyr His Leu Gly Glu  Phe Ser Val Thr Pro  Ile Leu Ser 
    1460                 1465                 1470             


Ala Arg  Tyr Asp Ala Asn Gln  Gly Ser Gly Lys Ile  Asn Val Asn 
    1475                 1480                 1485             


Gly Tyr  Asp Phe Ala Tyr Asn  Val Glu Asn Gln Gln  Gln Tyr Asn 
    1490                 1495                 1500             


Ala Gly  Leu Lys Leu Lys Tyr  His Asn Val Lys Leu  Ser Leu Ile 
    1505                 1510                 1515             


Gly Gly  Leu Thr Lys Ala Lys  Gln Ala Glu Lys Gln  Lys Thr Ala 
    1520                 1525                 1530             


Glu Leu  Lys Leu Ser Phe Ser  Phe 
    1535                 1540     


<210>  5
<211>  5096
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(5096)
<223>  encodes IgA1 protease (See GenBank entry M87492)

<400>  5
catcattacg ccttaaatta accaaaagtg cggtaaaaaa tagccaattt tttaaaaaat       60

atcaaaaatc attatcatta cctcgtaaat gtaattcaag ttttgagcga tttatgctat      120

aaaacccact cattataaaa atgaagacaa cttgcaaact atcaatgcaa cacagccaag      180

atttgaatca acttgtagcc gtatatcaaa ttgtgtccta tcaaatctac tttttaaact      240

taattaataa agacagcttc tatgctaaat aaaaaattca aactcaattt tattgcactt      300

actgtcgcct acgcattaac cccttataca gaagccgcgt tagtgagaga cgatgtggat      360

tatcaaatat tccgtgattt tgcagagaat aaagggaagt tttctgttgg tgcaacaaat      420

gtgctggtaa aggataaaaa taataaagat ttgggcactg ccttacctaa cggtattccg      480

atgattgatt ttagcgtggt agatgtagat aaacgcattg ccacattgat aaatccacaa      540

tatgtagtag gtgtaaaaca cgttagtaac ggcgtgagtg aactacattt tggtaactta      600

aacggcaata tgaataatgg caatgccaag gcacaccgag atgtatcttc agaagaaaat      660

agatattttt ccgttgagaa aaatgagtat ccaactaaat tgaatggaaa aacagtaact      720

acggaagatc aaactcaaaa acgccgtgaa gactactata tgccacgtct tgataaattt      780

gttacggaag ttgcaccaat agaggcttca accgcaagta gtgatgctgg cacatataat      840

gatcagaata aatatcctgc ttttgtaaga ctaggaagtg gtagtcaatt tatttataaa      900

aaaggagata attacagctt aattttaaat aatcatgagg ttggaggcaa taatcttaaa      960

ttggtgggcg atgcctatac ctatggtatt gcaggtacac cttataaagt aaaccacgag     1020

aataatggac taattggttt tggcaattca aaagaggaac acagcgatcc aaaaggaata     1080

ttatctcaag atcctcttac caattatgct gttttaggcg acagtggctc cccattattt     1140

gtatatgata gagaaaaagg aaaatggctt tttcttgggt cttatgattt ttgggcgggt     1200

tataacaaaa aatcttggca agaatggaat atttataaat ctcaatttac taaagatgtt     1260

ctcaataaag atagtgcagg ttctttaatt ggttccaaga cagattatag ttggtcttct     1320

aatggcaaga caagtacgat tacgggaggg gagaaatctt taaatgttga tttagctgac     1380

ggaaaagata aacctaatca cgggaaaagt gttacatttg aagggagtgg aacgcttacc     1440

ttaaataata atatcgatca aggtgcaggc ggattattct ttgaaggcga ttatgaagtt     1500

aaaggtactt ctgataatac tacttggaaa ggagcaggtg tctctgttgc cgaaggaaaa     1560

actgtaacgt ggaaagtgca taatcctcaa tatgatcgtt tagcaaaaat tggcaaaggg     1620

acattaattg ttgaaggaac aggagataat aaaggttcgc taaaagtggg cgatggcacc     1680

gttattttaa aacaacaaac aaatggttcg ggacaacacg cttttgcttc tgtagggatt     1740

gtaagtggtc gctcaactct tgtgcttaat gatgataaac aagtagatcc aaattcaatt     1800

tactttggct ttagaggcgg tcgattagac ttaaacggta attcactaac ctttgatcac     1860

atcagaaata ttgatgatgg tgcaagacta gttaatcata atatgactaa tgcctcaaat     1920

ataacgatta ctggggaaag tctaattaca gatccaaata caattactcc atataatata     1980

gacgcaccag atgaagataa tccttatgcc tttcgacgga ttaaagatgg aggacagctc     2040

tatttaaatt tggaaaatta cacttattat gcgttaagaa aaggtgcgag cactcgttca     2100

gaattaccta aaaatagtgg cgaaagcaat gaaaattggc tatatatggg taaaacttcc     2160

gatgaagcca aaagaaatgt aatgaaccat atcaacaacg agcgtatgaa tggctttaat     2220

ggttattttg gcgaggaaga gggtaaaaat aacggtaatc taaatgtgac ttttaaaggc     2280

aaaagtgagc aaaatcgctt tttattaaca ggcggtacaa accttaatgg cgatttaacg     2340

gttgaaaaag gcaccttatt cctttcaggc agaccaacac cgcacgcaag agatattgca     2400

ggtatttctt cgacaaaaaa agatcctcac tttgctgaaa ataatgaagt ggtagtagaa     2460

gatgactgga ttaaccgcaa ttttaaagca accacaatga acgtgactgg caatgcctca     2520

ctttattcag gtcgcaatgt tgcaaacatt acgtcaaata tcacagcttc taataaagca     2580

caagttcata tcggctataa aacaggcgat accgtttgtg tacgttctga ctatacgggc     2640

tatgtgactt gtactactga caagttatcc gataaagccc ttaatagctt taatccaacc     2700

aatctacgcg gcaatgtaaa tttaaccgaa agtgcaaact ttgtcttagg caaagccaac     2760

ttattcggca caattcaaag cagaggaaat agccaagtac gtttaaccga aaatagccat     2820

tggcatttaa caggaaatag tgatgttcat caattagatc tagcaaatgg gcatattcat     2880

ttaaattcag cagacaattc aaacaatgtg acaaaatata acacgctgac tgtgaatagc     2940

ttatcaggta acggttcttt ctattattta actgatcttt ccaataaaca aggcgacaaa     3000

gttgttgtaa ctaaatccgc cacaggtaac tttacattac aagtggcaga taaaacaggc     3060

gagccaaatc ataatgaact cacacttttt gatgcttcaa aagctcaaag agatcatttg     3120

aatgtgtcat tagttgggaa taccgttgat ttaggtgctt ggaaatataa attacgtaat     3180

gttaatggac gttacgattt gtataaccca gaggtggaaa aaagaaatca aactgtcgat     3240

acgacaaata tcacaacacc taataatatt caagctgatg tgcctagcgt accaagtaac     3300

aatgaagaaa tagcccgtgt tgatgaagca ccagttccac cacctgcgcc tgctacacca     3360

tcagagacaa ctgaaacagt ggctgaaaat agtaagcaag aaagtaaaac agtagagaaa     3420

aacgagcaag acgcaaccga gacaacagct caaaatagag aagttgcaaa agaagctaaa     3480

tcaaatgtaa aagctaatac tcaaacaaat gaagtagctc aaagtggaag tgaaaccaag     3540

gaaactcaaa cgactgaaac aaaagaaaca gctacggtag aaaaagaaga aaaggctaaa     3600

gtagaaacag agaaaactca agaagtccct aaagtgactt ctcaagtgtc tccgaaacag     3660

gaacagtctg aaactgttca accgcaagca gagcctgctc gtgaaaatga tccgactgtt     3720

aatataaaag agcctcaatc tcaaacaaat acaacagcag acactgaaca acctgcgaaa     3780

gagactagct caaatgttga acaaccagtg acagaaagca caacagtaaa cactggaaac     3840

tctgtagtgg aaaatccaga gaatacaaca cctgctacaa ctcaacctac ggttaattca     3900

gaaagcagta ataagccaaa gaatagacat agaagaagtg ttcgctcagt tccgcataat     3960

gttgaaccag ctacaacaag tagcaacgat cgttctacag tagcattgtg cgatctcaca     4020

agtacaaaca caaatgcggt actttctgat gcaagggcaa aagcacaatt tgttgcatta     4080

aatgtgggga aagcagtttc tcaacatatt agccagttag aaatgaataa cgaggggcaa     4140

tataacgttt gggtatctaa tacttcaatg aacaaaaatt attcctcaag tcaatatcgt     4200

cgttttagtt ctaaaagtac gcaaactcaa ctgggttggg atcaaacaat ctcaaacaat     4260

gttcagttag gtggcgtgtt tacttatgtt cgcaatagta acaactttga taaggcaaca     4320

agtaaaaata ctctagcaca agttaatttc tattctaaat attatgcgga taatcattgg     4380

tatttgggca ttgatttagg ctacggcaag ttccaaagca aattacaaac taatcataat     4440

gcgaaatttg ctcgccatac tgcacaattt ggtttaaccg caggcaaagc atttaatctt     4500

ggcaattttg gtattacgcc aatagtaggc gtgcgttata gctatttatc aaacgctgat     4560

tttgcattag atcaagctcg cattaaagta aatccaatat ctgtcaaaac agcctttgct     4620

caagttgatt taagttatac ttatcactta ggcgagtttt ccgttacgcc aattttgtct     4680

gctcgatatg atgcaaacca aggcagcgga aaaattaatg taaatggata tgattttgct     4740

tacaacgtgg aaaaccaaca gcaatataac gcagggctta aattgaaata tcataatgtg     4800

aaattaagtc taataggcgg attaacaaaa gcgaaacaag cggaaaaaca aaaaactgca     4860

gaattaaaac taagttttag tttttaataa gcctgtttga attaacgtta taaacaacaa     4920

agccctgtgt attacagggc tttatttttg aatgaaattc agtgattaag tgcggtgaaa     4980

aatcagcgca ttttttattt ttaacgtaaa aacgctggaa tatttttctc atatgctgag     5040

attttgtctt cgtgctgaag ggttaaaccg atattatcta aaccgtttag caaaca         5096


<210>  6
<211>  1541
<212>  PRT
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(1541)
<223>  full-length precursor IgA1 protease (See GenBank entry M87492)

<400>  6

Met Leu Asn Lys Lys Phe Lys Leu Asn Phe Ile Ala Leu Thr Val Ala 
1               5                   10                  15      


Tyr Ala Leu Thr Pro Tyr Thr Glu Ala Ala Leu Val Arg Asp Asp Val 
            20                  25                  30          


Asp Tyr Gln Ile Phe Arg Asp Phe Ala Glu Asn Lys Gly Lys Phe Ser 
        35                  40                  45              


Val Gly Ala Thr Asn Val Leu Val Lys Asp Lys Asn Asn Lys Asp Leu 
    50                  55                  60                  


Gly Thr Ala Leu Pro Asn Gly Ile Pro Met Ile Asp Phe Ser Val Val 
65                  70                  75                  80  


Asp Val Asp Lys Arg Ile Ala Thr Leu Ile Asn Pro Gln Tyr Val Val 
                85                  90                  95      


Gly Val Lys His Val Ser Asn Gly Val Ser Glu Leu His Phe Gly Asn 
            100                 105                 110         


Leu Asn Gly Asn Met Asn Asn Gly Asn Ala Lys Ala His Arg Asp Val 
        115                 120                 125             


Ser Ser Glu Glu Asn Arg Tyr Phe Ser Val Glu Lys Asn Glu Tyr Pro 
    130                 135                 140                 


Thr Lys Leu Asn Gly Lys Thr Val Thr Thr Glu Asp Gln Thr Gln Lys 
145                 150                 155                 160 


Arg Arg Glu Asp Tyr Tyr Met Pro Arg Leu Asp Lys Phe Val Thr Glu 
                165                 170                 175     


Val Ala Pro Ile Glu Ala Ser Thr Ala Ser Ser Asp Ala Gly Thr Tyr 
            180                 185                 190         


Asn Asp Gln Asn Lys Tyr Pro Ala Phe Val Arg Leu Gly Ser Gly Ser 
        195                 200                 205             


Gln Phe Ile Tyr Lys Lys Gly Asp Asn Tyr Ser Leu Ile Leu Asn Asn 
    210                 215                 220                 


His Glu Val Gly Gly Asn Asn Leu Lys Leu Val Gly Asp Ala Tyr Thr 
225                 230                 235                 240 


Tyr Gly Ile Ala Gly Thr Pro Tyr Lys Val Asn His Glu Asn Asn Gly 
                245                 250                 255     


Leu Ile Gly Phe Gly Asn Ser Lys Glu Glu His Ser Asp Pro Lys Gly 
            260                 265                 270         


Ile Leu Ser Gln Asp Pro Leu Thr Asn Tyr Ala Val Leu Gly Asp Ser 
        275                 280                 285             


Gly Ser Pro Leu Phe Val Tyr Asp Arg Glu Lys Gly Lys Trp Leu Phe 
    290                 295                 300                 


Leu Gly Ser Tyr Asp Phe Trp Ala Gly Tyr Asn Lys Lys Ser Trp Gln 
305                 310                 315                 320 


Glu Trp Asn Ile Tyr Lys Ser Gln Phe Thr Lys Asp Val Leu Asn Lys 
                325                 330                 335     


Asp Ser Ala Gly Ser Leu Ile Gly Ser Lys Thr Asp Tyr Ser Trp Ser 
            340                 345                 350         


Ser Asn Gly Lys Thr Ser Thr Ile Thr Gly Gly Glu Lys Ser Leu Asn 
        355                 360                 365             


Val Asp Leu Ala Asp Gly Lys Asp Lys Pro Asn His Gly Lys Ser Val 
    370                 375                 380                 


Thr Phe Glu Gly Ser Gly Thr Leu Thr Leu Asn Asn Asn Ile Asp Gln 
385                 390                 395                 400 


Gly Ala Gly Gly Leu Phe Phe Glu Gly Asp Tyr Glu Val Lys Gly Thr 
                405                 410                 415     


Ser Asp Asn Thr Thr Trp Lys Gly Ala Gly Val Ser Val Ala Glu Gly 
            420                 425                 430         


Lys Thr Val Thr Trp Lys Val His Asn Pro Gln Tyr Asp Arg Leu Ala 
        435                 440                 445             


Lys Ile Gly Lys Gly Thr Leu Ile Val Glu Gly Thr Gly Asp Asn Lys 
    450                 455                 460                 


Gly Ser Leu Lys Val Gly Asp Gly Thr Val Ile Leu Lys Gln Gln Thr 
465                 470                 475                 480 


Asn Gly Ser Gly Gln His Ala Phe Ala Ser Val Gly Ile Val Ser Gly 
                485                 490                 495     


Arg Ser Thr Leu Val Leu Asn Asp Asp Lys Gln Val Asp Pro Asn Ser 
            500                 505                 510         


Ile Tyr Phe Gly Phe Arg Gly Gly Arg Leu Asp Leu Asn Gly Asn Ser 
        515                 520                 525             


Leu Thr Phe Asp His Ile Arg Asn Ile Asp Asp Gly Ala Arg Leu Val 
    530                 535                 540                 


Asn His Asn Met Thr Asn Ala Ser Asn Ile Thr Ile Thr Gly Glu Ser 
545                 550                 555                 560 


Leu Ile Thr Asp Pro Asn Thr Ile Thr Pro Tyr Asn Ile Asp Ala Pro 
                565                 570                 575     


Asp Glu Asp Asn Pro Tyr Ala Phe Arg Arg Ile Lys Asp Gly Gly Gln 
            580                 585                 590         


Leu Tyr Leu Asn Leu Glu Asn Tyr Thr Tyr Tyr Ala Leu Arg Lys Gly 
        595                 600                 605             


Ala Ser Thr Arg Ser Glu Leu Pro Lys Asn Ser Gly Glu Ser Asn Glu 
    610                 615                 620                 


Asn Trp Leu Tyr Met Gly Lys Thr Ser Asp Glu Ala Lys Arg Asn Val 
625                 630                 635                 640 


Met Asn His Ile Asn Asn Glu Arg Met Asn Gly Phe Asn Gly Tyr Phe 
                645                 650                 655     


Gly Glu Glu Glu Gly Lys Asn Asn Gly Asn Leu Asn Val Thr Phe Lys 
            660                 665                 670         


Gly Lys Ser Glu Gln Asn Arg Phe Leu Leu Thr Gly Gly Thr Asn Leu 
        675                 680                 685             


Asn Gly Asp Leu Thr Val Glu Lys Gly Thr Leu Phe Leu Ser Gly Arg 
    690                 695                 700                 


Pro Thr Pro His Ala Arg Asp Ile Ala Gly Ile Ser Ser Thr Lys Lys 
705                 710                 715                 720 


Asp Pro His Phe Ala Glu Asn Asn Glu Val Val Val Glu Asp Asp Trp 
                725                 730                 735     


Ile Asn Arg Asn Phe Lys Ala Thr Thr Met Asn Val Thr Gly Asn Ala 
            740                 745                 750         


Ser Leu Tyr Ser Gly Arg Asn Val Ala Asn Ile Thr Ser Asn Ile Thr 
        755                 760                 765             


Ala Ser Asn Lys Ala Gln Val His Ile Gly Tyr Lys Thr Gly Asp Thr 
    770                 775                 780                 


Val Cys Val Arg Ser Asp Tyr Thr Gly Tyr Val Thr Cys Thr Thr Asp 
785                 790                 795                 800 


Lys Leu Ser Asp Lys Ala Leu Asn Ser Phe Asn Pro Thr Asn Leu Arg 
                805                 810                 815     


Gly Asn Val Asn Leu Thr Glu Ser Ala Asn Phe Val Leu Gly Lys Ala 
            820                 825                 830         


Asn Leu Phe Gly Thr Ile Gln Ser Arg Gly Asn Ser Gln Val Arg Leu 
        835                 840                 845             


Thr Glu Asn Ser His Trp His Leu Thr Gly Asn Ser Asp Val His Gln 
    850                 855                 860                 


Leu Asp Leu Ala Asn Gly His Ile His Leu Asn Ser Ala Asp Asn Ser 
865                 870                 875                 880 


Asn Asn Val Thr Lys Tyr Asn Thr Leu Thr Val Asn Ser Leu Ser Gly 
                885                 890                 895     


Asn Gly Ser Phe Tyr Tyr Leu Thr Asp Leu Ser Asn Lys Gln Gly Asp 
            900                 905                 910         


Lys Val Val Val Thr Lys Ser Ala Thr Gly Asn Phe Thr Leu Gln Val 
        915                 920                 925             


Ala Asp Lys Thr Gly Glu Pro Asn His Asn Glu Leu Thr Leu Phe Asp 
    930                 935                 940                 


Ala Ser Lys Ala Gln Arg Asp His Leu Asn Val Ser Leu Val Gly Asn 
945                 950                 955                 960 


Thr Val Asp Leu Gly Ala Trp Lys Tyr Lys Leu Arg Asn Val Asn Gly 
                965                 970                 975     


Arg Tyr Asp Leu Tyr Asn Pro Glu Val Glu Lys Arg Asn Gln Thr Val 
            980                 985                 990         


Asp Thr Thr Asn Ile Thr Thr Pro  Asn Asn Ile Gln Ala  Asp Val Pro 
        995                 1000                 1005             


Ser Val  Pro Ser Asn Asn Glu  Glu Ile Ala Arg Val  Asp Glu Ala 
    1010                 1015                 1020             


Pro Val  Pro Pro Pro Ala Pro  Ala Thr Pro Ser Glu  Thr Thr Glu 
    1025                 1030                 1035             


Thr Val  Ala Glu Asn Ser Lys  Gln Glu Ser Lys Thr  Val Glu Lys 
    1040                 1045                 1050             


Asn Glu  Gln Asp Ala Thr Glu  Thr Thr Ala Gln Asn  Arg Glu Val 
    1055                 1060                 1065             


Ala Lys  Glu Ala Lys Ser Asn  Val Lys Ala Asn Thr  Gln Thr Asn 
    1070                 1075                 1080             


Glu Val  Ala Gln Ser Gly Ser  Glu Thr Lys Glu Thr  Gln Thr Thr 
    1085                 1090                 1095             


Glu Thr  Lys Glu Thr Ala Thr  Val Glu Lys Glu Glu  Lys Ala Lys 
    1100                 1105                 1110             


Val Glu  Thr Glu Lys Thr Gln  Glu Val Pro Lys Val  Thr Ser Gln 
    1115                 1120                 1125             


Val Ser  Pro Lys Gln Glu Gln  Ser Glu Thr Val Gln  Pro Gln Ala 
    1130                 1135                 1140             


Glu Pro  Ala Arg Glu Asn Asp  Pro Thr Val Asn Ile  Lys Glu Pro 
    1145                 1150                 1155             


Gln Ser  Gln Thr Asn Thr Thr  Ala Asp Thr Glu Gln  Pro Ala Lys 
    1160                 1165                 1170             


Glu Thr  Ser Ser Asn Val Glu  Gln Pro Val Thr Glu  Ser Thr Thr 
    1175                 1180                 1185             


Val Asn  Thr Gly Asn Ser Val  Val Glu Asn Pro Glu  Asn Thr Thr 
    1190                 1195                 1200             


Pro Ala  Thr Thr Gln Pro Thr  Val Asn Ser Glu Ser  Ser Asn Lys 
    1205                 1210                 1215             


Pro Lys  Asn Arg His Arg Arg  Ser Val Arg Ser Val  Pro His Asn 
    1220                 1225                 1230             


Val Glu  Pro Ala Thr Thr Ser  Ser Asn Asp Arg Ser  Thr Val Ala 
    1235                 1240                 1245             


Leu Cys  Asp Leu Thr Ser Thr  Asn Thr Asn Ala Val  Leu Ser Asp 
    1250                 1255                 1260             


Ala Arg  Ala Lys Ala Gln Phe  Val Ala Leu Asn Val  Gly Lys Ala 
    1265                 1270                 1275             


Val Ser  Gln His Ile Ser Gln  Leu Glu Met Asn Asn  Glu Gly Gln 
    1280                 1285                 1290             


Tyr Asn  Val Trp Val Ser Asn  Thr Ser Met Asn Lys  Asn Tyr Ser 
    1295                 1300                 1305             


Ser Ser  Gln Tyr Arg Arg Phe  Ser Ser Lys Ser Thr  Gln Thr Gln 
    1310                 1315                 1320             


Leu Gly  Trp Asp Gln Thr Ile  Ser Asn Asn Val Gln  Leu Gly Gly 
    1325                 1330                 1335             


Val Phe  Thr Tyr Val Arg Asn  Ser Asn Asn Phe Asp  Lys Ala Thr 
    1340                 1345                 1350             


Ser Lys  Asn Thr Leu Ala Gln  Val Asn Phe Tyr Ser  Lys Tyr Tyr 
    1355                 1360                 1365             


Ala Asp  Asn His Trp Tyr Leu  Gly Ile Asp Leu Gly  Tyr Gly Lys 
    1370                 1375                 1380             


Phe Gln  Ser Lys Leu Gln Thr  Asn His Asn Ala Lys  Phe Ala Arg 
    1385                 1390                 1395             


His Thr  Ala Gln Phe Gly Leu  Thr Ala Gly Lys Ala  Phe Asn Leu 
    1400                 1405                 1410             


Gly Asn  Phe Gly Ile Thr Pro  Ile Val Gly Val Arg  Tyr Ser Tyr 
    1415                 1420                 1425             


Leu Ser  Asn Ala Asp Phe Ala  Leu Asp Gln Ala Arg  Ile Lys Val 
    1430                 1435                 1440             


Asn Pro  Ile Ser Val Lys Thr  Ala Phe Ala Gln Val  Asp Leu Ser 
    1445                 1450                 1455             


Tyr Thr  Tyr His Leu Gly Glu  Phe Ser Val Thr Pro  Ile Leu Ser 
    1460                 1465                 1470             


Ala Arg  Tyr Asp Ala Asn Gln  Gly Ser Gly Lys Ile  Asn Val Asn 
    1475                 1480                 1485             


Gly Tyr  Asp Phe Ala Tyr Asn  Val Glu Asn Gln Gln  Gln Tyr Asn 
    1490                 1495                 1500             


Ala Gly  Leu Lys Leu Lys Tyr  His Asn Val Lys Leu  Ser Leu Ile 
    1505                 1510                 1515             


Gly Gly  Leu Thr Lys Ala Lys  Gln Ala Glu Lys Gln  Lys Thr Ala 
    1520                 1525                 1530             


Glu Leu  Lys Leu Ser Phe Ser  Phe 
    1535                 1540     


<210>  7
<211>  6021
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(6021)
<223>  encodes IgA1 protease (See GenBank M87491 entry)

<400>  7
ttttgagcga tttatgctat aaagttcgcc cattataaag atgaagacaa cttgcaaact       60

atcaacgcaa cacagccaaa atttgaatca acttgtaacc gtatatcaaa ttgtgtccta      120

tcaaatctac tttttaaact taattaataa ggacagcttc tatgctaaat aaaaaattca      180

aactcaattt tattgcgctt actgtcgcct acgcattaac cccttataca gaagccgcgt      240

tagtgagaga cgatgtggat tatcaaatat tccgtgattt tgcagagaat aaagggaagt      300

tttctgttgg tgcaacaaat gtggaagtga gagataaaaa gaaccaatct ttaggcagtg      360

ccttacctaa cggtattccg atgattgatt ttagcgtggt ggatgtagat aagagaattg      420

ccacgttggt aaatccacaa tatgtagtag gcgtaaaaca cgttagtaac ggcgtgagtg      480

aactacattt tggtaactta aacggcaata tgaataatgg caatgctaaa tcgcaccgag      540

atgtatcctc tgaagaaaac cgatattaca ccgttgaaaa aaataatttc cctacagaga      600

atgtaacatc tttcacaaca aaagaagaac aagatgctca aaaacgccgt gaagattatt      660

atatgcctcg ccttgataaa tttgttaccg aagttgcacc aatagaggct tcaactgcaa      720

acaacaataa aggagagtat aacaattctg ataaataccc agcttttgta agacttggta      780

gtggctctca atttatctat aaaaaaggaa gtcgttatca attaatcttg acggaaaagg      840

ataaacaagg aaatctgttg agaaactggg atgttggtgg agataatctc gaactagttg      900

gtaatgctta tacctatggt attgcaggta caccttataa agtaaaccac gagaataatg      960

gactaattgg ttttggcaat tcaaaagagg aacacagcga tccaaaagga atattatctc     1020

aagatcctct taccaattat gctgttttag gcgacagtgg ctccccatta tttgtatatg     1080

atagagaaaa aggaaaatgg ctttttcttg gatcctatga tttctgggcg ggttataaca     1140

aaaaatcttg gcaagaatgg aatatctata aacatgaatt tgcagaaaaa atttatcaac     1200

aatatagtgc aggttcttta actggttcta acacccaata tacttggcaa gccactggca     1260

gtacaagtac gattacgggg ggaggggaac ctttaagtgt tgatttaact gacggaaaag     1320

ataaacctaa tcacggaaaa agtatcactc ttaaaggaag tggaacactt accttaaata     1380

atcatatcga tcaaggtgca ggcggcttgt tttttgaagg cgattatgaa gttaaaggca     1440

cttctgatag taccacttgg aaaggagcgg gcgtttctgt tgctgatgga aaaacagtaa     1500

cgtggaaagt acataacccg aaatatgatc gattagctaa aattggtaaa gggacattag     1560

ttgtagaagg aaaagggaaa aatgaaggat tacttaaagt tggcgatggt actgttatct     1620

taaaacagaa agctgatgcc aataataaag ttcaagcctt ttcacaagta ggtatagtga     1680

gtggtcgctc aacccttgtg cttaatgatg ataaacaagt agatccaaat tcaatttact     1740

ttggctttag aggcggtcga ttagatttaa acggtaattc actaaccttt gaccacatca     1800

gaaatattga tgatggggca agagtggtta atcataatat gaccaatacc tcaaatataa     1860

cgattactgg ggaaagtcta attacaaatc caaatacaat tacttcatat aatatagaag     1920

cacaagatga cgaccaccct ttacgaattc gttcaatacc gtacagacag ctgtatttta     1980

atcaggataa cagatcctat tacacattaa aaaaaggtgc tagcactcgt tcagaattgc     2040

ctcaaaacag cggagaaagc aacgaaaatt ggttatatat gggtagaact tccgatgaag     2100

ccaaaagaaa tgtaatgaac catatcaaca acgagcgtat gaatggcttt aatggttatt     2160

ttggcgagga agaaactaag gcaactcaaa acggcaaatt aaacgttacc tttaatggca     2220

aaagtgatca aaatcgcttt ttattaacag gcggaacaaa ccttaatggc gatttaaatg     2280

ttgaaaaagg cacattattc ctttcaggca gacctacacc gcacgcaaga gatattgcgg     2340

gtatttcttc aacgaagaaa gatcctcact tcactgaaaa taatgaagtg gtggtagaag     2400

acgactggat taaccgcaat tttaaagcaa ccacaatgaa cgtgactggc aatgcctcac     2460

tttattcggg acgcaatgtt gcaaatatta cttcaaatat cacagcttct aataatgcac     2520

aagtgcatat tggctataaa acaggcgata ccgtttgtgt acgttctgac tatacgggct     2580

atgtaacttg ccataatagc aatttatcgg aaaaagcact caatagtttt aatccaacca     2640

atctacgcgg caatgtaaat ttaaccgaaa atgcaagctt taccttaggc aaggctaact     2700

tattcggcac aattcaaagc attggaacta gccaagttaa tttaaaagaa aatagccatt     2760

ggcatttaac aggcaatagc aatgttaatc agttaaattt aaccaatggg catattcatt     2820

taaatgcaca aaacgatgct aataaagtaa ctacatataa cacactgaca gtgaatagct     2880

tatcaggtaa cggttctttc tattattggg ttgattttac caataataaa agtaacaaag     2940

ttgttgtaaa taaatccgcc acaggtaact ttacattaca agtagcagat aaaacaggcg     3000

agccaaatca taatgaactc acgctttttg atgcttcaaa tgctacaaga aataatttag     3060

aagtaacact agctaatggc agtgttgatc gaggtgcttg gaaatataaa ttacgtaatg     3120

ttaatggacg ttacgattta tataacccag aggtggaaaa aagaaatcaa actgtcgata     3180

cgacaaatat cacaacacct aatgatattc aagctgatgc acctagcgca caaagtaaca     3240

atgaagaaat agcccgtgtt gaaacaccag ttccaccacc tgcacctgct actgaatcag     3300

caatagcaag cgagcaacca gaaactcgtc ctgcagaaac cgctcaacca gcgatggaag     3360

agacaaatac tgctaactca acggaaactg ctccaaaatc tgataccgca acacaaactg     3420

aaaatccaaa ttcagaaagt gttccatcag agacaactga aaaagtggct gaaaatcctc     3480

cgcaagaaaa tgaaacagtc gcgaaaaacg agcaagaagc aaccgaacca acacctcaaa     3540

atggagaagt tgcaaaagaa gatcaaccaa ctgtagaagc taacactcaa acaaatgaag     3600

ccacccaaag tgagggcaaa accgaggaaa ctcaaacggc tgaaacaaaa tctgaaccta     3660

cagagagtgt aactgtatca gaaaatcaac cagaaaaaac tgtttctcaa tcaacagaag     3720

ataaggttgt tgtagaaaaa gaggaaaagg ctaaagtaga aacagaggaa actcaaaaag     3780

ccccacaagt gacttctaaa gagcctccga aacaagcaga gcctgctcct gaagaagttc     3840

cgactgatac aaatgcagaa gaagctcaag ctctacagca aacacaaccg acaactgttg     3900

ctgcggcaga gacgacttcg ccaaacagta aaccagcgga agaaactcaa caaccaagtg     3960

aaaaaactaa cgctgaacct gtaacgcctg tagtatcaga aaatacggct acccaaccaa     4020

cagaaacaga ggaaacggct aaagtagaaa aagagaaaac tcaagaagtc cctcaagtgg     4080

cttctcaaga atctcctaaa caggaacagc ctgcagctaa accacaagct caaactaaac     4140

cgcaagcaga gcctgctcgt gaaaatgttc tgactactaa aaatgtagga gagcctcaac     4200

ctcaagctca accgcagaca caatcgacag cagttcctac gacgggggaa actgcagcga     4260

acagtaaacc tgcagctaaa ccacaagctc aagctaaacc gcaaacagag cctgctcgtg     4320

aaaatgtttc gactgttaat acaaaagagc ctcaatcgca aacaagtgca acagtaagca     4380

ctgaacaacc tgcgaaagag actagctcaa atgttgaaca acctgcacca gagaattcaa     4440

taaatactgg atctgcaacc acaatgacag aaactgctga aaaatccgat aaaccacaaa     4500

tggaaactgt gaccgaaaat gatcgtcagc ctgaagctaa tactgttgcg gataattctg     4560

tagcaaataa ttcagaaagc agtgagtcaa agagtagacg tagaagaagt gttagccagc     4620

ctaaagagac ttctgctgaa gaaacaacag tagcttctac tcaagaaaca acagtggata     4680

attcagtatc tactccaaaa ccacgaagca gaagaactcg tagatcagtg cagacaaata     4740

gttacgagcc agtggaacta cctactgaaa atgcggagaa tgcggagaat gtgcaatcgg     4800

gaaataatgt ggctaattca caaccagcat tacgcaatct cacaagtaaa aacaccaatg     4860

cggtactttc taatgcaatg gcaaaagcac aatttgttgc attaaatgta gggaaagccg     4920

tttctcaaca tattagccag ttagaaatga ataacgaggg gcaatataac gtttggatat     4980

ctaatacttc aatgaacaaa aattattcct cagagcaata tcgtcgtttt agttctaaaa     5040

gtacgcaaac tcaacttggt tgggatcaaa caatctcaaa caatgttcag ttaggtggcg     5100

tgtttactta tgttcgcaat agtaacaact ttgataaggc aagcagtaaa aatactctag     5160

cacaagttaa tttctattct aaatattatg cggataatca ttggtatttg ggcattgatt     5220

taggctacgg caagttccaa agcaacctac aaaccaataa taatgcgaaa tttgctcgcc     5280

atactgcaca aattggttta accgcaggca aagcatttaa tcttggcaat tttgctgtta     5340

aaccaactgt aggggttcgt tatagttact tatcaaacgc tgattttgca ttagctcaag     5400

atcgcattaa agtaaatcca atatctgtca aaacagcctt tgctcaagtt gatttaagtt     5460

atacttatca cttaggcgag ttttccatta cgccaatttt gtctgctcga tatgatgcaa     5520

atcaaggcaa tggcaaaatt aatgtaagtg tatatgattt tgcttacaac gtggaaaacc     5580

aacagcaata taacgcggga cttaaattga aatatcataa tgtgaaatta agtctaattg     5640

gtggattaac aaaagcaaaa caagcggaaa aacaaaaaac agcggaagtg aaactaagtt     5700

ttagttttta ataagcctgt ttgaattagc gttatagacg acaaagccct gtgtattaca     5760

gggctttatt tttgaatgaa attcagtgat taagtgcggt gaaaaatcag ctcatttttt     5820

atttttaacg taaaaacgct ggaatatttt tttcgtatgc tgagattttg tcttcgtgct     5880

gcaaggttaa gccgatattg tccaatccgt ttaacaaaca atgacggcgg aattcatcca     5940

gttcaaagtg ataaacttta tccccaacag tgaccgtcat cgcttctaaa tctacgtgga     6000

tttgcttgct ttcatttgcc c                                               6021


<210>  8
<211>  1849
<212>  PRT
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(1849)
<223>  full-length precursor IgA1 protease (See GenBank entry M87491)

<400>  8

Met Leu Asn Lys Lys Phe Lys Leu Asn Phe Ile Ala Leu Thr Val Ala 
1               5                   10                  15      


Tyr Ala Leu Thr Pro Tyr Thr Glu Ala Ala Leu Val Arg Asp Asp Val 
            20                  25                  30          


Asp Tyr Gln Ile Phe Arg Asp Phe Ala Glu Asn Lys Gly Lys Phe Ser 
        35                  40                  45              


Val Gly Ala Thr Asn Val Glu Val Arg Asp Lys Lys Asn Gln Ser Leu 
    50                  55                  60                  


Gly Ser Ala Leu Pro Asn Gly Ile Pro Met Ile Asp Phe Ser Val Val 
65                  70                  75                  80  


Asp Val Asp Lys Arg Ile Ala Thr Leu Val Asn Pro Gln Tyr Val Val 
                85                  90                  95      


Gly Val Lys His Val Ser Asn Gly Val Ser Glu Leu His Phe Gly Asn 
            100                 105                 110         


Leu Asn Gly Asn Met Asn Asn Gly Asn Ala Lys Ser His Arg Asp Val 
        115                 120                 125             


Ser Ser Glu Glu Asn Arg Tyr Tyr Thr Val Glu Lys Asn Asn Phe Pro 
    130                 135                 140                 


Thr Glu Asn Val Thr Ser Phe Thr Thr Lys Glu Glu Gln Asp Ala Gln 
145                 150                 155                 160 


Lys Arg Arg Glu Asp Tyr Tyr Met Pro Arg Leu Asp Lys Phe Val Thr 
                165                 170                 175     


Glu Val Ala Pro Ile Glu Ala Ser Thr Ala Asn Asn Asn Lys Gly Glu 
            180                 185                 190         


Tyr Asn Asn Ser Asp Lys Tyr Pro Ala Phe Val Arg Leu Gly Ser Gly 
        195                 200                 205             


Ser Gln Phe Ile Tyr Lys Lys Gly Ser Arg Tyr Gln Leu Ile Leu Thr 
    210                 215                 220                 


Glu Lys Asp Lys Gln Gly Asn Leu Leu Arg Asn Trp Asp Val Gly Gly 
225                 230                 235                 240 


Asp Asn Leu Glu Leu Val Gly Asn Ala Tyr Thr Tyr Gly Ile Ala Gly 
                245                 250                 255     


Thr Pro Tyr Lys Val Asn His Glu Asn Asn Gly Leu Ile Gly Phe Gly 
            260                 265                 270         


Asn Ser Lys Glu Glu His Ser Asp Pro Lys Gly Ile Leu Ser Gln Asp 
        275                 280                 285             


Pro Leu Thr Asn Tyr Ala Val Leu Gly Asp Ser Gly Ser Pro Leu Phe 
    290                 295                 300                 


Val Tyr Asp Arg Glu Lys Gly Lys Trp Leu Phe Leu Gly Ser Tyr Asp 
305                 310                 315                 320 


Phe Trp Ala Gly Tyr Asn Lys Lys Ser Trp Gln Glu Trp Asn Ile Tyr 
                325                 330                 335     


Lys His Glu Phe Ala Glu Lys Ile Tyr Gln Gln Tyr Ser Ala Gly Ser 
            340                 345                 350         


Leu Thr Gly Ser Asn Thr Gln Tyr Thr Trp Gln Ala Thr Gly Ser Thr 
        355                 360                 365             


Ser Thr Ile Thr Gly Gly Gly Glu Pro Leu Ser Val Asp Leu Thr Asp 
    370                 375                 380                 


Gly Lys Asp Lys Pro Asn His Gly Lys Ser Ile Thr Leu Lys Gly Ser 
385                 390                 395                 400 


Gly Thr Leu Thr Leu Asn Asn His Ile Asp Gln Gly Ala Gly Gly Leu 
                405                 410                 415     


Phe Phe Glu Gly Asp Tyr Glu Val Lys Gly Thr Ser Asp Ser Thr Thr 
            420                 425                 430         


Trp Lys Gly Ala Gly Val Ser Val Ala Asp Gly Lys Thr Val Thr Trp 
        435                 440                 445             


Lys Val His Asn Pro Lys Tyr Asp Arg Leu Ala Lys Ile Gly Lys Gly 
    450                 455                 460                 


Thr Leu Val Val Glu Gly Lys Gly Lys Asn Glu Gly Leu Leu Lys Val 
465                 470                 475                 480 


Gly Asp Gly Thr Val Ile Leu Lys Gln Lys Ala Asp Ala Asn Asn Lys 
                485                 490                 495     


Val Gln Ala Phe Ser Gln Val Gly Ile Val Ser Gly Arg Ser Thr Leu 
            500                 505                 510         


Val Leu Asn Asp Asp Lys Gln Val Asp Pro Asn Ser Ile Tyr Phe Gly 
        515                 520                 525             


Phe Arg Gly Gly Arg Leu Asp Leu Asn Gly Asn Ser Leu Thr Phe Asp 
    530                 535                 540                 


His Ile Arg Asn Ile Asp Asp Gly Ala Arg Val Val Asn His Asn Met 
545                 550                 555                 560 


Thr Asn Thr Ser Asn Ile Thr Ile Thr Gly Glu Ser Leu Ile Thr Asn 
                565                 570                 575     


Pro Asn Thr Ile Thr Ser Tyr Asn Ile Glu Ala Gln Asp Asp Asp His 
            580                 585                 590         


Pro Leu Arg Ile Arg Ser Ile Pro Tyr Arg Gln Leu Tyr Phe Asn Gln 
        595                 600                 605             


Asp Asn Arg Ser Tyr Tyr Thr Leu Lys Lys Gly Ala Ser Thr Arg Ser 
    610                 615                 620                 


Glu Leu Pro Gln Asn Ser Gly Glu Ser Asn Glu Asn Trp Leu Tyr Met 
625                 630                 635                 640 


Gly Arg Thr Ser Asp Glu Ala Lys Arg Asn Val Met Asn His Ile Asn 
                645                 650                 655     


Asn Glu Arg Met Asn Gly Phe Asn Gly Tyr Phe Gly Glu Glu Glu Thr 
            660                 665                 670         


Lys Ala Thr Gln Asn Gly Lys Leu Asn Val Thr Phe Asn Gly Lys Ser 
        675                 680                 685             


Asp Gln Asn Arg Phe Leu Leu Thr Gly Gly Thr Asn Leu Asn Gly Asp 
    690                 695                 700                 


Leu Asn Val Glu Lys Gly Thr Leu Phe Leu Ser Gly Arg Pro Thr Pro 
705                 710                 715                 720 


His Ala Arg Asp Ile Ala Gly Ile Ser Ser Thr Lys Lys Asp Pro His 
                725                 730                 735     


Phe Thr Glu Asn Asn Glu Val Val Val Glu Asp Asp Trp Ile Asn Arg 
            740                 745                 750         


Asn Phe Lys Ala Thr Thr Met Asn Val Thr Gly Asn Ala Ser Leu Tyr 
        755                 760                 765             


Ser Gly Arg Asn Val Ala Asn Ile Thr Ser Asn Ile Thr Ala Ser Asn 
    770                 775                 780                 


Asn Ala Gln Val His Ile Gly Tyr Lys Thr Gly Asp Thr Val Cys Val 
785                 790                 795                 800 


Arg Ser Asp Tyr Thr Gly Tyr Val Thr Cys His Asn Ser Asn Leu Ser 
                805                 810                 815     


Glu Lys Ala Leu Asn Ser Phe Asn Pro Thr Asn Leu Arg Gly Asn Val 
            820                 825                 830         


Asn Leu Thr Glu Asn Ala Ser Phe Thr Leu Gly Lys Ala Asn Leu Phe 
        835                 840                 845             


Gly Thr Ile Gln Ser Ile Gly Thr Ser Gln Val Asn Leu Lys Glu Asn 
    850                 855                 860                 


Ser His Trp His Leu Thr Gly Asn Ser Asn Val Asn Gln Leu Asn Leu 
865                 870                 875                 880 


Thr Asn Gly His Ile His Leu Asn Ala Gln Asn Asp Ala Asn Lys Val 
                885                 890                 895     


Thr Thr Tyr Asn Thr Leu Thr Val Asn Ser Leu Ser Gly Asn Gly Ser 
            900                 905                 910         


Phe Tyr Tyr Trp Val Asp Phe Thr Asn Asn Lys Ser Asn Lys Val Val 
        915                 920                 925             


Val Asn Lys Ser Ala Thr Gly Asn Phe Thr Leu Gln Val Ala Asp Lys 
    930                 935                 940                 


Thr Gly Glu Pro Asn His Asn Glu Leu Thr Leu Phe Asp Ala Ser Asn 
945                 950                 955                 960 


Ala Thr Arg Asn Asn Leu Glu Val Thr Leu Ala Asn Gly Ser Val Asp 
                965                 970                 975     


Arg Gly Ala Trp Lys Tyr Lys Leu Arg Asn Val Asn Gly Arg Tyr Asp 
            980                 985                 990         


Leu Tyr Asn Pro Glu Val Glu Lys  Arg Asn Gln Thr Val  Asp Thr Thr 
        995                 1000                 1005             


Asn Ile  Thr Thr Pro Asn Asp  Ile Gln Ala Asp Ala  Pro Ser Ala 
    1010                 1015                 1020             


Gln Ser  Asn Asn Glu Glu Ile  Ala Arg Val Glu Thr  Pro Val Pro 
    1025                 1030                 1035             


Pro Pro  Ala Pro Ala Thr Glu  Ser Ala Ile Ala Ser  Glu Gln Pro 
    1040                 1045                 1050             


Glu Thr  Arg Pro Ala Glu Thr  Ala Gln Pro Ala Met  Glu Glu Thr 
    1055                 1060                 1065             


Asn Thr  Ala Asn Ser Thr Glu  Thr Ala Pro Lys Ser  Asp Thr Ala 
    1070                 1075                 1080             


Thr Gln  Thr Glu Asn Pro Asn  Ser Glu Ser Val Pro  Ser Glu Thr 
    1085                 1090                 1095             


Thr Glu  Lys Val Ala Glu Asn  Pro Pro Gln Glu Asn  Glu Thr Val 
    1100                 1105                 1110             


Ala Lys  Asn Glu Gln Glu Ala  Thr Glu Pro Thr Pro  Gln Asn Gly 
    1115                 1120                 1125             


Glu Val  Ala Lys Glu Asp Gln  Pro Thr Val Glu Ala  Asn Thr Gln 
    1130                 1135                 1140             


Thr Asn  Glu Ala Thr Gln Ser  Glu Gly Lys Thr Glu  Glu Thr Gln 
    1145                 1150                 1155             


Thr Ala  Glu Thr Lys Ser Glu  Pro Thr Glu Ser Val  Thr Val Ser 
    1160                 1165                 1170             


Glu Asn  Gln Pro Glu Lys Thr  Val Ser Gln Ser Thr  Glu Asp Lys 
    1175                 1180                 1185             


Val Val  Val Glu Lys Glu Glu  Lys Ala Lys Val Glu  Thr Glu Glu 
    1190                 1195                 1200             


Thr Gln  Lys Ala Pro Gln Val  Thr Ser Lys Glu Pro  Pro Lys Gln 
    1205                 1210                 1215             


Ala Glu  Pro Ala Pro Glu Glu  Val Pro Thr Asp Thr  Asn Ala Glu 
    1220                 1225                 1230             


Glu Ala  Gln Ala Leu Gln Gln  Thr Gln Pro Thr Thr  Val Ala Ala 
    1235                 1240                 1245             


Ala Glu  Thr Thr Ser Pro Asn  Ser Lys Pro Ala Glu  Glu Thr Gln 
    1250                 1255                 1260             


Gln Pro  Ser Glu Lys Thr Asn  Ala Glu Pro Val Thr  Pro Val Val 
    1265                 1270                 1275             


Ser Glu  Asn Thr Ala Thr Gln  Pro Thr Glu Thr Glu  Glu Thr Ala 
    1280                 1285                 1290             


Lys Val  Glu Lys Glu Lys Thr  Gln Glu Val Pro Gln  Val Ala Ser 
    1295                 1300                 1305             


Gln Glu  Ser Pro Lys Gln Glu  Gln Pro Ala Ala Lys  Pro Gln Ala 
    1310                 1315                 1320             


Gln Thr  Lys Pro Gln Ala Glu  Pro Ala Arg Glu Asn  Val Leu Thr 
    1325                 1330                 1335             


Thr Lys  Asn Val Gly Glu Pro  Gln Pro Gln Ala Gln  Pro Gln Thr 
    1340                 1345                 1350             


Gln Ser  Thr Ala Val Pro Thr  Thr Gly Glu Thr Ala  Ala Asn Ser 
    1355                 1360                 1365             


Lys Pro  Ala Ala Lys Pro Gln  Ala Gln Ala Lys Pro  Gln Thr Glu 
    1370                 1375                 1380             


Pro Ala  Arg Glu Asn Val Ser  Thr Val Asn Thr Lys  Glu Pro Gln 
    1385                 1390                 1395             


Ser Gln  Thr Ser Ala Thr Val  Ser Thr Glu Gln Pro  Ala Lys Glu 
    1400                 1405                 1410             


Thr Ser  Ser Asn Val Glu Gln  Pro Ala Pro Glu Asn  Ser Ile Asn 
    1415                 1420                 1425             


Thr Gly  Ser Ala Thr Thr Met  Thr Glu Thr Ala Glu  Lys Ser Asp 
    1430                 1435                 1440             


Lys Pro  Gln Met Glu Thr Val  Thr Glu Asn Asp Arg  Gln Pro Glu 
    1445                 1450                 1455             


Ala Asn  Thr Val Ala Asp Asn  Ser Val Ala Asn Asn  Ser Glu Ser 
    1460                 1465                 1470             


Ser Glu  Ser Lys Ser Arg Arg  Arg Arg Ser Val Ser  Gln Pro Lys 
    1475                 1480                 1485             


Glu Thr  Ser Ala Glu Glu Thr  Thr Val Ala Ser Thr  Gln Glu Thr 
    1490                 1495                 1500             


Thr Val  Asp Asn Ser Val Ser  Thr Pro Lys Pro Arg  Ser Arg Arg 
    1505                 1510                 1515             


Thr Arg  Arg Ser Val Gln Thr  Asn Ser Tyr Glu Pro  Val Glu Leu 
    1520                 1525                 1530             


Pro Thr  Glu Asn Ala Glu Asn  Ala Glu Asn Val Gln  Ser Gly Asn 
    1535                 1540                 1545             


Asn Val  Ala Asn Ser Gln Pro  Ala Leu Arg Asn Leu  Thr Ser Lys 
    1550                 1555                 1560             


Asn Thr  Asn Ala Val Leu Ser  Asn Ala Met Ala Lys  Ala Gln Phe 
    1565                 1570                 1575             


Val Ala  Leu Asn Val Gly Lys  Ala Val Ser Gln His  Ile Ser Gln 
    1580                 1585                 1590             


Leu Glu  Met Asn Asn Glu Gly  Gln Tyr Asn Val Trp  Ile Ser Asn 
    1595                 1600                 1605             


Thr Ser  Met Asn Lys Asn Tyr  Ser Ser Glu Gln Tyr  Arg Arg Phe 
    1610                 1615                 1620             


Ser Ser  Lys Ser Thr Gln Thr  Gln Leu Gly Trp Asp  Gln Thr Ile 
    1625                 1630                 1635             


Ser Asn  Asn Val Gln Leu Gly  Gly Val Phe Thr Tyr  Val Arg Asn 
    1640                 1645                 1650             


Ser Asn  Asn Phe Asp Lys Ala  Ser Ser Lys Asn Thr  Leu Ala Gln 
    1655                 1660                 1665             


Val Asn  Phe Tyr Ser Lys Tyr  Tyr Ala Asp Asn His  Trp Tyr Leu 
    1670                 1675                 1680             


Gly Ile  Asp Leu Gly Tyr Gly  Lys Phe Gln Ser Asn  Leu Gln Thr 
    1685                 1690                 1695             


Asn Asn  Asn Ala Lys Phe Ala  Arg His Thr Ala Gln  Ile Gly Leu 
    1700                 1705                 1710             


Thr Ala  Gly Lys Ala Phe Asn  Leu Gly Asn Phe Ala  Val Lys Pro 
    1715                 1720                 1725             


Thr Val  Gly Val Arg Tyr Ser  Tyr Leu Ser Asn Ala  Asp Phe Ala 
    1730                 1735                 1740             


Leu Ala  Gln Asp Arg Ile Lys  Val Asn Pro Ile Ser  Val Lys Thr 
    1745                 1750                 1755             


Ala Phe  Ala Gln Val Asp Leu  Ser Tyr Thr Tyr His  Leu Gly Glu 
    1760                 1765                 1770             


Phe Ser  Ile Thr Pro Ile Leu  Ser Ala Arg Tyr Asp  Ala Asn Gln 
    1775                 1780                 1785             


Gly Asn  Gly Lys Ile Asn Val  Ser Val Tyr Asp Phe  Ala Tyr Asn 
    1790                 1795                 1800             


Val Glu  Asn Gln Gln Gln Tyr  Asn Ala Gly Leu Lys  Leu Lys Tyr 
    1805                 1810                 1815             


His Asn  Val Lys Leu Ser Leu  Ile Gly Gly Leu Thr  Lys Ala Lys 
    1820                 1825                 1830             


Gln Ala  Glu Lys Gln Lys Thr  Ala Glu Val Lys Leu  Ser Phe Ser 
    1835                 1840                 1845             


Phe 
    


<210>  9
<211>  5088
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(5088)
<223>  encodes IgA1 protease (See GenBank entry M87490)

<400>  9
aaacccactc attataaaaa tgaagacaac ttgcaaacta tcaatgcaac acagccaaga       60

tttgaatcaa cttgtagccg tatatcaaat tgtgtcctat caaatctact ttttaaactt      120

aattaataaa gacagcttct atgctaaata aaaaattcaa actcaatttt attgcactta      180

ctgtcgccta cgcattaacc ccttatacag aagccgcgtt agtgagagac gatgtggatt      240

atcaaatatt tcgtgatttt gcagagaata aagggaagtt ttctgttggt gcaacaaatg      300

tggaagtgag agataaaaat aaccgacctt taggcaatgt tttacctaat ggtattccga      360

tgattgattt tagtgttgtg gatgtagata agagaattgc cacgttggta aatccacaat      420

atgtagtagg cgtaaaacac gttagtaacg gcgtgagtga actacatttt gggaacttaa      480

atggcaatat gaataatggc aatgctaaag cacaccgaga tgtatcctct gaagaaaacc      540

gatattacac cgttgaaaaa aacgagtatc caactaaatt aaatggaaaa gcagtaacta      600

ctgaagatca agctcaaaaa cgccgtgaag attattatat gccacgtctt gataaatttg      660

ttaccgaagt tgcaccaata gaggcttcaa ctgatagtag tacagcgggg acatataata      720

ataaagataa atatccttac tttgtaagac ttggtagtgg tactcaattt atttatgaaa      780

atggaacacg ctatgaatta tggttaggta aagaagggca gaaaagcgat gcgggcggct      840

ataatcttaa attagttggt aatgcttata cctatggtat tgcaggtacg ccttatgaag      900

taaatcacga gaacgatggg cttatcggct tcggcaactc aaataatgaa tacattaatc      960

caaaagaaat attatccaaa aaaccactta ctaattacgc tgttttaggg gacagcggat     1020

ccccattatt tgtatatgat agagaaaaag gaaaatggct tttccttggt tcttatgatt     1080

actgggctgg ttataacaaa aaatcttggc aggaatggaa tatctataaa cctgaatttg     1140

cagaaaaaat ttatgaacaa tatagtgcag gttctttaat tggttccaag acagattata     1200

gttggtcttc taatggcaag acaagtacga ttacgggagg ggagaaatct ttaaatgttg     1260

atttagctga cggaaaagat aaacctaatc acgggaaaag tgttacattt gaagggagtg     1320

gaacgcttac cttaaataat aatatcgatc aaggtgcagg cggattattc tttgaaggcg     1380

attatgaagt taaaggtact tctgataata ctacttggaa aggagcaggt gtctctgttg     1440

ccgaaggaaa aactgtaacg tggaaagtgc ataatcctca atatgatcgt ttagcaaaaa     1500

ttggcaaagg gacattaatt gttgaaggaa caggagataa taaaggttcg ctaaaagtgg     1560

gcgatggcac cgttatttta aaacaacaaa caaatggttc gggacaacac gcttttgctt     1620

ctgtagggat tgtaagtggt cgctcaactc ttgtgcttaa tgatgataaa caagtagatc     1680

caaattcaat ttactttgga tttagaggcg gtcgattaga tttaaacggt aattcactaa     1740

cctttgacca catcagaaat attgatgaag gtgcgagact ggttaatcac agtaccagta     1800

aacactctac agtgacaatt actggggata atttgattac agatccaaat aatgtctcta     1860

tatattatgt aaaaccacta gaggacgata atccttatgc cattcggcaa ataaaatatg     1920

gataccaact ctattttaat gaagaaaaca gaacttatta tgcattaaaa aaagatgcta     1980

gtattcgctc agaatttcct caaaacagag gagaaagcaa taatagttgg ctatatatgg     2040

gaacagagaa agctgacgct caaaaaaatg caatgaacca tatcaacaac gagcgtatga     2100

atggctttaa cggttatttt ggtgaggaag aaggtaaaaa taacggtaat ctaaatgtga     2160

cttttaaagg caaaagtgag caaaatcgct ttttattaac aggcggaaca aaccttaatg     2220

gcgatttaaa tgttcaacaa ggtacattat tcctttctgg cagacctaca ccacacgcaa     2280

gagatattgc gggtatttct tcaacgaaga aagattcaca cttttctgaa aataatgaag     2340

tggtggtaga agacgactgg attaaccgca attttaaagc aacaaatatt aatgtaacca     2400

ataacgcaac cctttattca ggtcgcaatg ttgaaagtat tacttcaaat atcacagctt     2460

ctaataatgc aaaagtgcat atcggctata aagcaggcga taccgtttgt gtacgttctg     2520

actatacggg ctatgtgact tgtactactg acaagttatc cgataaagcc cttaatagct     2580

ttaatccaac caatctacgc ggcaatgtaa atttaaccga aagtgcaaac tttgtcttag     2640

gcaaagccaa cttattcggc acaattcaaa gcagaggaaa tagccaagta cgtttaaccg     2700

aaaatagcca ttggcattta acaggaaata gtgatgttca tcaattagat ctagcaaatg     2760

ggcatattca tttaaattca gcagacaatt caaacaatgt gacaaaatat aacacgctga     2820

ctgtgaatag cttatcaggt aacggttctt tctattattt aactgatctt tccaataaac     2880

aaggcgacaa agttgttgta actaaatccg ccacaggtaa ctttacatta caagtggcag     2940

ataaaacagg cgagccaaat cataatgaac tcacactttt tgatgcttca aaagctcaaa     3000

gagatcattt gaatgtgtca ttagttggga ataccgttga tttaggtgct tggaaatata     3060

aattacgtaa tgttaatgga cgttacgatt tgtataaccc agaggtggaa aaaagaaatc     3120

aaactgtcga tacgacaaat atcacaacac ctaataatat tcaagctgat gtgcctagcg     3180

taccaagtaa caatgaagaa atagcccgtg ttgatgaagc accagttcca ccacctgcgc     3240

ctgctacacc atcagagaca actgaaacag tggctgaaaa tagtaagcaa gaaagtaaaa     3300

cagtagagaa aaacgagcaa gacgcaaccg agacaacagc tcaaaataga gaagttgcaa     3360

aagaagctaa atcaaatgta aaagctaata ctcaaacaaa tgaagtagct caaagtggaa     3420

gtgaaaccaa ggaaactcaa acgactgaaa caaaagaaac agctacggta gaaaaagaag     3480

aaaaggctaa agtagaaaca gagaaaactc aagaagtccc taaagtgact tctcaagtgt     3540

ctccgaaaca ggaacagtct gaaactgttc aaccgcaagc agagcctgct cgtgaaaatg     3600

atccgactgt taatataaaa gagcctcaat ctcaaacaaa tacaacagca gacactgaac     3660

aacctgcgaa agagactagc tcaaatgttg aacaaccagt gacagaaagc acaacagtaa     3720

acactggaaa ctctgtagtg gaaaatccag agaatacaac acctgctaca actcaaccta     3780

cggttaattc agaaagcagt aataagccaa agaatagaca tagaagaagt gttcgctcag     3840

ttccgcataa tgttgaacca gctacaacaa gtagcaacga tcgttctaca gtagcattgt     3900

gcgatctcac aagtacaaac acaaatgcgg tactttctga tgcaagggca aaagcacaat     3960

ttgttgcatt aaatgtgggg aaagcagttt ctcaacatat tagccagtta gaaatgaata     4020

acgaggggca atataacgtt tgggtatcta atacttcaat gaacaaaaat tattcctcaa     4080

gtcaatatcg tcgttttagt tctaaaagta cgcaaactca actgggttgg gatcaaacaa     4140

tctcaaacaa tgttcagtta ggtggcgtgt ttacttatgt tcgcaatagt aacaactttg     4200

ataaggcaac aagtaaaaat actctagcac aagttaattt ctattctaaa tattatgcgg     4260

ataatcattg gtatttgggc attgatttag gctacggcaa gttccaaagc aaattacaaa     4320

ctaatcataa tgcgaaattt gctcgccata ctgcacaatt tggtttaacc gcaggcaaag     4380

catttaatct tggcaatttt ggtattacgc caatagtagg cgtgcgttat agctatttat     4440

caaacgctga ttttgcatta gatcaagctc gcattaaagt aaatccaata tctgtcaaaa     4500

cagcctttgc tcaagttgat ttaagttata cttatcactt aggcgagttt tccgttacgc     4560

caattttgtc tgctcgatat gatgcaaacc aaggcagcgg aaaaattaat gtaaatggat     4620

atgattttgc ttacaacgtg gaaaaccaac agcaatataa cgcagggctt aaattgaaat     4680

atcataatgt gaaattaagt ctaataggcg gattaacaaa agcgaaacaa gcggaaaaac     4740

aaaaaactgc agaattaaaa ctaagtttta gtttttaata agcctgtttg aattaacgtt     4800

ataaacaaca aagccctgtg tattacaggg ctttattttt gaatgaaatt cagtgattaa     4860

gtgcggtgaa aaatcagcgc attttttatt tttaacgtaa aaacgctgga atatttttct     4920

catatgctga gattttgtct tcgtgctgaa gggttaaacc gatattatct aaaccgttta     4980

gcaaacaatg gcggcgaaat tcatcaagct caaaagtata aactttatcc ccatacgtga     5040

ccgtcatcgc ttctaaatct atgtggattt gcttgctttc atttgccc                  5088


<210>  10
<211>  1545
<212>  PRT
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(1545)
<223>  full-length precursor IgA1 protease (See GenBank M87490 entry)

<400>  10

Met Leu Asn Lys Lys Phe Lys Leu Asn Phe Ile Ala Leu Thr Val Ala 
1               5                   10                  15      


Tyr Ala Leu Thr Pro Tyr Thr Glu Ala Ala Leu Val Arg Asp Asp Val 
            20                  25                  30          


Asp Tyr Gln Ile Phe Arg Asp Phe Ala Glu Asn Lys Gly Lys Phe Ser 
        35                  40                  45              


Val Gly Ala Thr Asn Val Glu Val Arg Asp Lys Asn Asn Arg Pro Leu 
    50                  55                  60                  


Gly Asn Val Leu Pro Asn Gly Ile Pro Met Ile Asp Phe Ser Val Val 
65                  70                  75                  80  


Asp Val Asp Lys Arg Ile Ala Thr Leu Val Asn Pro Gln Tyr Val Val 
                85                  90                  95      


Gly Val Lys His Val Ser Asn Gly Val Ser Glu Leu His Phe Gly Asn 
            100                 105                 110         


Leu Asn Gly Asn Met Asn Asn Gly Asn Ala Lys Ala His Arg Asp Val 
        115                 120                 125             


Ser Ser Glu Glu Asn Arg Tyr Tyr Thr Val Glu Lys Asn Glu Tyr Pro 
    130                 135                 140                 


Thr Lys Leu Asn Gly Lys Ala Val Thr Thr Glu Asp Gln Ala Gln Lys 
145                 150                 155                 160 


Arg Arg Glu Asp Tyr Tyr Met Pro Arg Leu Asp Lys Phe Val Thr Glu 
                165                 170                 175     


Val Ala Pro Ile Glu Ala Ser Thr Asp Ser Ser Thr Ala Gly Thr Tyr 
            180                 185                 190         


Asn Asn Lys Asp Lys Tyr Pro Tyr Phe Val Arg Leu Gly Ser Gly Thr 
        195                 200                 205             


Gln Phe Ile Tyr Glu Asn Gly Thr Arg Tyr Glu Leu Trp Leu Gly Lys 
    210                 215                 220                 


Glu Gly Gln Lys Ser Asp Ala Gly Gly Tyr Asn Leu Lys Leu Val Gly 
225                 230                 235                 240 


Asn Ala Tyr Thr Tyr Gly Ile Ala Gly Thr Pro Tyr Glu Val Asn His 
                245                 250                 255     


Glu Asn Asp Gly Leu Ile Gly Phe Gly Asn Ser Asn Asn Glu Tyr Ile 
            260                 265                 270         


Asn Pro Lys Glu Ile Leu Ser Lys Lys Pro Leu Thr Asn Tyr Ala Val 
        275                 280                 285             


Leu Gly Asp Ser Gly Ser Pro Leu Phe Val Tyr Asp Arg Glu Lys Gly 
    290                 295                 300                 


Lys Trp Leu Phe Leu Gly Ser Tyr Asp Tyr Trp Ala Gly Tyr Asn Lys 
305                 310                 315                 320 


Lys Ser Trp Gln Glu Trp Asn Ile Tyr Lys Pro Glu Phe Ala Glu Lys 
                325                 330                 335     


Ile Tyr Glu Gln Tyr Ser Ala Gly Ser Leu Ile Gly Ser Lys Thr Asp 
            340                 345                 350         


Tyr Ser Trp Ser Ser Asn Gly Lys Thr Ser Thr Ile Thr Gly Gly Glu 
        355                 360                 365             


Lys Ser Leu Asn Val Asp Leu Ala Asp Gly Lys Asp Lys Pro Asn His 
    370                 375                 380                 


Gly Lys Ser Val Thr Phe Glu Gly Ser Gly Thr Leu Thr Leu Asn Asn 
385                 390                 395                 400 


Asn Ile Asp Gln Gly Ala Gly Gly Leu Phe Phe Glu Gly Asp Tyr Glu 
                405                 410                 415     


Val Lys Gly Thr Ser Asp Asn Thr Thr Trp Lys Gly Ala Gly Val Ser 
            420                 425                 430         


Val Ala Glu Gly Lys Thr Val Thr Trp Lys Val His Asn Pro Gln Tyr 
        435                 440                 445             


Asp Arg Leu Ala Lys Ile Gly Lys Gly Thr Leu Ile Val Glu Gly Thr 
    450                 455                 460                 


Gly Asp Asn Lys Gly Ser Leu Lys Val Gly Asp Gly Thr Val Ile Leu 
465                 470                 475                 480 


Lys Gln Gln Thr Asn Gly Ser Gly Gln His Ala Phe Ala Ser Val Gly 
                485                 490                 495     


Ile Val Ser Gly Arg Ser Thr Leu Val Leu Asn Asp Asp Lys Gln Val 
            500                 505                 510         


Asp Pro Asn Ser Ile Tyr Phe Gly Phe Arg Gly Gly Arg Leu Asp Leu 
        515                 520                 525             


Asn Gly Asn Ser Leu Thr Phe Asp His Ile Arg Asn Ile Asp Glu Gly 
    530                 535                 540                 


Ala Arg Leu Val Asn His Ser Thr Ser Lys His Ser Thr Val Thr Ile 
545                 550                 555                 560 


Thr Gly Asp Asn Leu Ile Thr Asp Pro Asn Asn Val Ser Ile Tyr Tyr 
                565                 570                 575     


Val Lys Pro Leu Glu Asp Asp Asn Pro Tyr Ala Ile Arg Gln Ile Lys 
            580                 585                 590         


Tyr Gly Tyr Gln Leu Tyr Phe Asn Glu Glu Asn Arg Thr Tyr Tyr Ala 
        595                 600                 605             


Leu Lys Lys Asp Ala Ser Ile Arg Ser Glu Phe Pro Gln Asn Arg Gly 
    610                 615                 620                 


Glu Ser Asn Asn Ser Trp Leu Tyr Met Gly Thr Glu Lys Ala Asp Ala 
625                 630                 635                 640 


Gln Lys Asn Ala Met Asn His Ile Asn Asn Glu Arg Met Asn Gly Phe 
                645                 650                 655     


Asn Gly Tyr Phe Gly Glu Glu Glu Gly Lys Asn Asn Gly Asn Leu Asn 
            660                 665                 670         


Val Thr Phe Lys Gly Lys Ser Glu Gln Asn Arg Phe Leu Leu Thr Gly 
        675                 680                 685             


Gly Thr Asn Leu Asn Gly Asp Leu Asn Val Gln Gln Gly Thr Leu Phe 
    690                 695                 700                 


Leu Ser Gly Arg Pro Thr Pro His Ala Arg Asp Ile Ala Gly Ile Ser 
705                 710                 715                 720 


Ser Thr Lys Lys Asp Ser His Phe Ser Glu Asn Asn Glu Val Val Val 
                725                 730                 735     


Glu Asp Asp Trp Ile Asn Arg Asn Phe Lys Ala Thr Asn Ile Asn Val 
            740                 745                 750         


Thr Asn Asn Ala Thr Leu Tyr Ser Gly Arg Asn Val Glu Ser Ile Thr 
        755                 760                 765             


Ser Asn Ile Thr Ala Ser Asn Asn Ala Lys Val His Ile Gly Tyr Lys 
    770                 775                 780                 


Ala Gly Asp Thr Val Cys Val Arg Ser Asp Tyr Thr Gly Tyr Val Thr 
785                 790                 795                 800 


Cys Thr Thr Asp Lys Leu Ser Asp Lys Ala Leu Asn Ser Phe Asn Pro 
                805                 810                 815     


Thr Asn Leu Arg Gly Asn Val Asn Leu Thr Glu Ser Ala Asn Phe Val 
            820                 825                 830         


Leu Gly Lys Ala Asn Leu Phe Gly Thr Ile Gln Ser Arg Gly Asn Ser 
        835                 840                 845             


Gln Val Arg Leu Thr Glu Asn Ser His Trp His Leu Thr Gly Asn Ser 
    850                 855                 860                 


Asp Val His Gln Leu Asp Leu Ala Asn Gly His Ile His Leu Asn Ser 
865                 870                 875                 880 


Ala Asp Asn Ser Asn Asn Val Thr Lys Tyr Asn Thr Leu Thr Val Asn 
                885                 890                 895     


Ser Leu Ser Gly Asn Gly Ser Phe Tyr Tyr Leu Thr Asp Leu Ser Asn 
            900                 905                 910         


Lys Gln Gly Asp Lys Val Val Val Thr Lys Ser Ala Thr Gly Asn Phe 
        915                 920                 925             


Thr Leu Gln Val Ala Asp Lys Thr Gly Glu Pro Asn His Asn Glu Leu 
    930                 935                 940                 


Thr Leu Phe Asp Ala Ser Lys Ala Gln Arg Asp His Leu Asn Val Ser 
945                 950                 955                 960 


Leu Val Gly Asn Thr Val Asp Leu Gly Ala Trp Lys Tyr Lys Leu Arg 
                965                 970                 975     


Asn Val Asn Gly Arg Tyr Asp Leu Tyr Asn Pro Glu Val Glu Lys Arg 
            980                 985                 990         


Asn Gln Thr Val Asp Thr Thr Asn  Ile Thr Thr Pro Asn  Asn Ile Gln 
        995                 1000                 1005             


Ala Asp  Val Pro Ser Val Pro  Ser Asn Asn Glu Glu  Ile Ala Arg 
    1010                 1015                 1020             


Val Asp  Glu Ala Pro Val Pro  Pro Pro Ala Pro Ala  Thr Pro Ser 
    1025                 1030                 1035             


Glu Thr  Thr Glu Thr Val Ala  Glu Asn Ser Lys Gln  Glu Ser Lys 
    1040                 1045                 1050             


Thr Val  Glu Lys Asn Glu Gln  Asp Ala Thr Glu Thr  Thr Ala Gln 
    1055                 1060                 1065             


Asn Arg  Glu Val Ala Lys Glu  Ala Lys Ser Asn Val  Lys Ala Asn 
    1070                 1075                 1080             


Thr Gln  Thr Asn Glu Val Ala  Gln Ser Gly Ser Glu  Thr Lys Glu 
    1085                 1090                 1095             


Thr Gln  Thr Thr Glu Thr Lys  Glu Thr Ala Thr Val  Glu Lys Glu 
    1100                 1105                 1110             


Glu Lys  Ala Lys Val Glu Thr  Glu Lys Thr Gln Glu  Val Pro Lys 
    1115                 1120                 1125             


Val Thr  Ser Gln Val Ser Pro  Lys Gln Glu Gln Ser  Glu Thr Val 
    1130                 1135                 1140             


Gln Pro  Gln Ala Glu Pro Ala  Arg Glu Asn Asp Pro  Thr Val Asn 
    1145                 1150                 1155             


Ile Lys  Glu Pro Gln Ser Gln  Thr Asn Thr Thr Ala  Asp Thr Glu 
    1160                 1165                 1170             


Gln Pro  Ala Lys Glu Thr Ser  Ser Asn Val Glu Gln  Pro Val Thr 
    1175                 1180                 1185             


Glu Ser  Thr Thr Val Asn Thr  Gly Asn Ser Val Val  Glu Asn Pro 
    1190                 1195                 1200             


Glu Asn  Thr Thr Pro Ala Thr  Thr Gln Pro Thr Val  Asn Ser Glu 
    1205                 1210                 1215             


Ser Ser  Asn Lys Pro Lys Asn  Arg His Arg Arg Ser  Val Arg Ser 
    1220                 1225                 1230             


Val Pro  His Asn Val Glu Pro  Ala Thr Thr Ser Ser  Asn Asp Arg 
    1235                 1240                 1245             


Ser Thr  Val Ala Leu Cys Asp  Leu Thr Ser Thr Asn  Thr Asn Ala 
    1250                 1255                 1260             


Val Leu  Ser Asp Ala Arg Ala  Lys Ala Gln Phe Val  Ala Leu Asn 
    1265                 1270                 1275             


Val Gly  Lys Ala Val Ser Gln  His Ile Ser Gln Leu  Glu Met Asn 
    1280                 1285                 1290             


Asn Glu  Gly Gln Tyr Asn Val  Trp Val Ser Asn Thr  Ser Met Asn 
    1295                 1300                 1305             


Lys Asn  Tyr Ser Ser Ser Gln  Tyr Arg Arg Phe Ser  Ser Lys Ser 
    1310                 1315                 1320             


Thr Gln  Thr Gln Leu Gly Trp  Asp Gln Thr Ile Ser  Asn Asn Val 
    1325                 1330                 1335             


Gln Leu  Gly Gly Val Phe Thr  Tyr Val Arg Asn Ser  Asn Asn Phe 
    1340                 1345                 1350             


Asp Lys  Ala Thr Ser Lys Asn  Thr Leu Ala Gln Val  Asn Phe Tyr 
    1355                 1360                 1365             


Ser Lys  Tyr Tyr Ala Asp Asn  His Trp Tyr Leu Gly  Ile Asp Leu 
    1370                 1375                 1380             


Gly Tyr  Gly Lys Phe Gln Ser  Lys Leu Gln Thr Asn  His Asn Ala 
    1385                 1390                 1395             


Lys Phe  Ala Arg His Thr Ala  Gln Phe Gly Leu Thr  Ala Gly Lys 
    1400                 1405                 1410             


Ala Phe  Asn Leu Gly Asn Phe  Gly Ile Thr Pro Ile  Val Gly Val 
    1415                 1420                 1425             


Arg Tyr  Ser Tyr Leu Ser Asn  Ala Asp Phe Ala Leu  Asp Gln Ala 
    1430                 1435                 1440             


Arg Ile  Lys Val Asn Pro Ile  Ser Val Lys Thr Ala  Phe Ala Gln 
    1445                 1450                 1455             


Val Asp  Leu Ser Tyr Thr Tyr  His Leu Gly Glu Phe  Ser Val Thr 
    1460                 1465                 1470             


Pro Ile  Leu Ser Ala Arg Tyr  Asp Ala Asn Gln Gly  Ser Gly Lys 
    1475                 1480                 1485             


Ile Asn  Val Asn Gly Tyr Asp  Phe Ala Tyr Asn Val  Glu Asn Gln 
    1490                 1495                 1500             


Gln Gln  Tyr Asn Ala Gly Leu  Lys Leu Lys Tyr His  Asn Val Lys 
    1505                 1510                 1515             


Leu Ser  Leu Ile Gly Gly Leu  Thr Lys Ala Lys Gln  Ala Glu Lys 
    1520                 1525                 1530             


Gln Lys  Thr Ala Glu Leu Lys  Leu Ser Phe Ser Phe  
    1535                 1540                 1545 


<210>  11
<211>  5536
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(5536)
<223>  encodes IgA1 protease (See GenBank entry M87489)

<400>  11
aaagatgaag acaacttgca aattatcaac gcaacacagc caaaatttga atcaacttgt       60

aaccgtatat caaattgtgt cctatcaaat ctacttttta aacttaatta ataaggacag      120

cttctatgct aaataaaaaa ttcaaactca attttattgc gcttactgtc gcctacgcat      180

taacccctta tacagaagct gcgttagtga gagacgatgt ggattatcaa atatttcgtg      240

attttgcaga aaataaaggg agattttctg ttggtgcaac aaatgtggaa gtgagagata      300

aaaataacca ctctttaggc aatgttttac ctaatggcat tccgatgatt gattttagtg      360

ttgtggatgt agataaacgc atcgccacat tgataaatcc acaatatgta gtaggtgtaa      420

aacacgttag taacggcgtg agtgaactac attttgggaa cttaaatggc aatatgaata      480

atggcaatga taaatcgcac cgagatgtat cttcagaaga aaatagatat ttttccgttg      540

agaaaaatga gtatccaact aaattgaatg gaaaagcagt aactactgaa gatcaaactc      600

aaaaacgccg tgaagactac tatatgccac gtcttgataa atttgttacc gaagttgcac      660

caatagaggc ttcaactgca agtagtgatg ctggcacata taatgatcag aataaatatc      720

ctgcttttgt aagactagga agtggtagtc aatttattta taaaaaagga gataattaca      780

gcttaatttt aaataatcat gaggttggag gcaataatct taaattggtg ggcgatgcct      840

atacctatgg tattgcaggc acaccttata aagtaaacca cgaaaataat ggactaattg      900

gttttggcaa ttcaaaagag gaacacagcg atccaaaagg aatattatct caagatccgc      960

ttaccaatta tgctgtttta ggcgacagtg gctccccatt atttgtatat gatagagaaa     1020

aaggaaaatg gctttttctt gggtcttatg atttttgggc aggttataac aaaaaatctt     1080

ggcaagaatg gaatatttat aaacctgaat ttgcaaaaac tgttctagat aaagatactg     1140

caggttcttt aactggttct aacacccaat acaattggaa tcctactggc aaaacaagcg     1200

ttatttctaa tggttctgaa tctctaaatg ttgatttatt cgatagtagt caggatactg     1260

actctaagaa gaacaatcac ggaaaaagtg tgactcttag aggaagtgga acgcttacct     1320

taaataataa tatcgatcaa ggcgcaggcg gcttgttctt tgaaggagat tatgaagtta     1380

aaggcacttc tgatagtacc acttggaaag gagctggcgt ttctgttgct gatggaaaaa     1440

cagtaacgtg gaaagtacat aacccgaaat ctgatcgttt agctaaaatc ggcaaaggaa     1500

cattaattgt agaaggaaag ggagaaaata aaggttcgct aaaagtgggc gatggtactg     1560

ttatcttaaa acaacaagct gatgccaata ataaagttaa agccttttca caagtaggta     1620

tagtaagtgg tcgctcaact gttgtactta atgatgataa gcaagtagat ccaaattcca     1680

tttactttgg ctttagaggt ggtcgattag atgccaatgg caataatctc acttttgaac     1740

atatccgtaa tattgatgat ggcgcaagac tagtaaatca caataccagc aaaacctcta     1800

ctgtaacaat tactggggaa agtctaatta cagatccaaa tacaattact ccatataata     1860

tagacgcacc agatgaagat aatccttatg cctttcgacg gattaaagat ggaggacagc     1920

tctatttaaa tttggaaaat tacacttatt atgcgttaag aaaaggtgcg agcactcgtt     1980

cagaattacc taaaaatagt ggcgaaagca atgaaaattg gctatatatg ggtaaaactt     2040

ccgatgaagc caaaagaaat gtaatgaacc atatcaacaa cgagcgtatg aatggcttta     2100

acggttattt tggcgaggaa gagggtaaaa ataacggtaa tctaaatgtg acttttaaag     2160

gcaaaagtga gcaaaatcgc tttttattaa caggcggaac aaaccttaat ggcgatttaa     2220

aggttgaaaa aggcacatta ttcctttctg gcagaccaac accgcacgca agagatattg     2280

caggtatttc ttcgacaaaa aaagatcaac actttgctga aaataatgaa gtggtagtag     2340

aagatgactg gattaaccgc aattttaaag caacaaatat taatgtaacc aataacgcaa     2400

ccctttattc aggtcgcaat gttgcaaaca ttacttcaaa tatcacagct tctgataatg     2460

caaaagtaca tattggctat aaagcaggcg ataccgtttg tgtacgttct gactatacgg     2520

gctatgtgac ttgcactact gacaagttat ccgataaagc ccttaatagc tttaacgcca     2580

ccaatgtatc tggcaatgta aatttatcag gtaatgcaaa ctttgtctta ggcaaagcta     2640

acttattcgg cacaattagc ggcacgggaa atagccaagt acgtttaacc gaaaatagcc     2700

attggcattt aacaggcgat agcaatgtta atcagttaaa tttagacaag gggcatattc     2760

atttaaatgc acaaaacgat gcaaataaag taactacata taacacgctg actgtgaata     2820

gcttatcagg taacggttct ttctattatt taactgatct ttccaataaa caaggcgaca     2880

aagttgttgt aactaaatcc gccacaggta actttacatt acaagtggca gataaaacag     2940

gcgagcctac aaaaaatgaa ctcacgcttt ttgatgcgtc aaatgctaca agaaataatt     3000

tgaatgtgtc attagttggg aataccgttg atttaggtgc ttggaaatat aaattacgta     3060

atgttaatgg acgttacgat ttgtataacc cagaggtgga aaaaagaaat caaactgtcg     3120

atacgacaaa tatcacaaca cctaataata ttcaagctga tgtgcctagc gtaccaagta     3180

acaatgaaga aatagcccgt gttgaaacac cagttccacc acctgcgcct gctacaccat     3240

cagagacaac tgaaacagtg gctgaaaata gtaagcaaga aagtaaaaca gtagagaaaa     3300

acgagcaaga cgcaaccgag acaacagctc aaaatggaga agttgcagaa gaagctaaac     3360

caagtgtaaa agctaatact caaacaaatg aagtggctca aagtggaagt gaaaccgagg     3420

aaactcaaac gactgaaata aaagaaacag ctaaagtaga aaaagaggaa aaggctaaag     3480

tagaaaaaga ggaaaaggct aaagtagaaa aagatgaaat tcaagaagca cctcaaatgg     3540

cttctgaaac gtctccgaaa caagcaaagc ctgctcctaa agaagtttca actgatacga     3600

aagtagaaga aactcaagtt caagctcaac cgcaaacaca atcgacaact gttgctgcgg     3660

cagaggcaac ttcgccaaac agtaaaccag cggaagaaac tcaaccaagt gaaaaaacta     3720

acgcagaacc tgtaacgcct gtagtatcaa aaaatcaaac agaaaatacg accgaccaac     3780

caacagaaag agagaaaacg gctaaagtag aaacagagaa aactcaagag ccccctcaag     3840

tggcttctca agcgtctccg aaacaggaac agtctgaaac tgttcaaccg caagcagtgc     3900

ttgaaagtga aaatgttccg actgttaata atgcagaaga agttcaagct caactgcaaa     3960

cacaaacaag tgcaacagta agcactaaac aacctgcacc agagaattca ataaatactg     4020

gatctgcaac cgcaataaca gaaactgctg aaaaatccga taaaccacaa acggaaactg     4080

cggcttcgac tgaagatgct agtcagcata aagcgaatac tgttgcggat aattctgtag     4140

caaataattc agaaagcagt gagccaaaga gtagacgtag aagaagtatt agccagcctc     4200

aagagacttc tgctgaagaa acaacagcag cttctactga cgaaacaaca atagctgata     4260

attcaaaacg cagtaagcca aatcgtagaa gtagaagaag tgttcgctcg gaaccaactg     4320

ttacaaatgg cagcgatcgt tctacagtag cattgcgcga tctcacaagt acaaacacaa     4380

atgcggtaat ttctgatgca atggcaaaag cacaatttgt tgcattaaat gtggggaaag     4440

cagtttctca acatattagc cagttagaaa tgaataacga ggggcaatat aacgtttggg     4500

tatctaatac ttcaatgaac gaaaattatt cctcaagtca atatcgtcgt tttagttcta     4560

aaagtacgca aactcaactt ggttgggatc aaacaatctc aaacaatgtt cagttaggtg     4620

gcgtgtttac ttatgttcgc aatagtaaca actttgataa ggcaagcagt aaaaatactc     4680

tagcacaagt taatttctat tctaaatatt atgcggataa tcattggtat ttgggcattg     4740

atttaggcta cggcaagttc caaagcaacc taaaaaccaa tcataatgcg aaatttgctc     4800

gccatactgc acaatttggt ttaaccgcag gcaaagcatt taatcttggc aattttggta     4860

ttacgccaat agtaggcgtg cgttatagct atttatcaaa cgctaatttt gcattagcta     4920

aagatcgcat taaagtaaat ccaatatctg tcaaaacagc ctttgctcaa gttgatttaa     4980

gttatactta tcacttaggc gagttttccg ttacgccaat tttgtctgct cgatatgata     5040

caaatcaagg cagcggaaaa attaatgtaa atcaatatga ttttgcttac aacgtggaaa     5100

accaacagca atataacgca gggcttaaat tgaaatatca taatgtgaaa ttaagtctaa     5160

taggcggatt aacaaaagcg aaacaagcgg aaaaacaaaa aactgcagaa ttaaaactaa     5220

gttttagttt ttaataagcc tgtttgaatt aacgttataa acaacaaagc cctgtgtctt     5280

acagggcttt atttttgaat gaaattcagt gattaagtgc ggtgaaaaat cagcgcattt     5340

tttattttta acgtaaaaac gctggaatat ttttctcgta tgctgagatt ttgtcttcgt     5400

gctgaagagt taagccgata ttatctaaac cgtttagcaa acaatggcgg cggaattcga     5460

gctcggtacc cggggatcct ctagagtcga cctgcaggca tgcaagcttg gcgtaatcat     5520

ggtcatagct gtttcc                                                     5536


<210>  12
<211>  1702
<212>  PRT
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(1702)
<223>  full-length precursor IgA1 protease (See GenBank entry X64357)

<400>  12

Met Leu Asn Lys Lys Phe Lys Leu Asn Phe Ile Ala Leu Thr Val Ala 
1               5                   10                  15      


Tyr Ala Leu Thr Pro Tyr Thr Glu Ala Ala Leu Val Arg Asp Asp Val 
            20                  25                  30          


Asp Tyr Gln Ile Phe Arg Asp Phe Ala Glu Asn Lys Gly Arg Phe Ser 
        35                  40                  45              


Val Gly Ala Thr Asn Val Glu Val Arg Asp Lys Asn Asn His Ser Leu 
    50                  55                  60                  


Gly Asn Val Leu Pro Asn Gly Ile Pro Met Ile Asp Phe Ser Val Val 
65                  70                  75                  80  


Asp Val Asp Lys Arg Ile Ala Thr Leu Ile Asn Pro Gln Tyr Val Val 
                85                  90                  95      


Gly Val Lys His Val Ser Asn Gly Val Ser Glu Leu His Phe Gly Asn 
            100                 105                 110         


Leu Asn Gly Asn Met Asn Asn Gly Asn Asp Lys Ser His Arg Asp Val 
        115                 120                 125             


Ser Ser Glu Glu Asn Arg Tyr Phe Ser Val Glu Lys Asn Glu Tyr Pro 
    130                 135                 140                 


Thr Lys Leu Asn Gly Lys Ala Val Thr Thr Glu Asp Gln Thr Gln Lys 
145                 150                 155                 160 


Arg Arg Glu Asp Tyr Tyr Met Pro Arg Leu Asp Lys Phe Val Thr Glu 
                165                 170                 175     


Val Ala Pro Ile Glu Ala Ser Thr Ala Ser Ser Asp Ala Gly Thr Tyr 
            180                 185                 190         


Asn Asp Gln Asn Lys Tyr Pro Ala Phe Val Arg Leu Gly Ser Gly Ser 
        195                 200                 205             


Gln Phe Ile Tyr Lys Lys Gly Asp Asn Tyr Ser Leu Ile Leu Asn Asn 
    210                 215                 220                 


His Glu Val Gly Gly Asn Asn Leu Lys Leu Val Gly Asp Ala Tyr Thr 
225                 230                 235                 240 


Tyr Gly Ile Ala Gly Thr Pro Tyr Lys Val Asn His Glu Asn Asn Gly 
                245                 250                 255     


Leu Ile Gly Phe Gly Asn Ser Lys Glu Glu His Ser Asp Pro Lys Gly 
            260                 265                 270         


Ile Leu Ser Gln Asp Pro Leu Thr Asn Tyr Ala Val Leu Gly Asp Ser 
        275                 280                 285             


Gly Ser Pro Leu Phe Val Tyr Asp Arg Glu Lys Gly Lys Trp Leu Phe 
    290                 295                 300                 


Leu Gly Ser Tyr Asp Phe Trp Ala Gly Tyr Asn Lys Lys Ser Trp Gln 
305                 310                 315                 320 


Glu Trp Asn Ile Tyr Lys Pro Glu Phe Ala Lys Thr Val Leu Asp Lys 
                325                 330                 335     


Asp Thr Ala Gly Ser Leu Thr Gly Ser Asn Thr Gln Tyr Asn Trp Asn 
            340                 345                 350         


Pro Thr Gly Lys Thr Ser Val Ile Ser Asn Gly Ser Glu Ser Leu Asn 
        355                 360                 365             


Val Asp Leu Phe Asp Ser Ser Gln Asp Thr Asp Ser Lys Lys Asn Asn 
    370                 375                 380                 


His Gly Lys Ser Val Thr Leu Arg Gly Ser Gly Thr Leu Thr Leu Asn 
385                 390                 395                 400 


Asn Asn Ile Asp Gln Gly Ala Gly Gly Leu Phe Phe Glu Gly Asp Tyr 
                405                 410                 415     


Glu Val Lys Gly Thr Ser Asp Ser Thr Thr Trp Lys Gly Ala Gly Val 
            420                 425                 430         


Ser Val Ala Asp Gly Lys Thr Val Thr Trp Lys Val His Asn Pro Lys 
        435                 440                 445             


Ser Asp Arg Leu Ala Lys Ile Gly Lys Gly Thr Leu Ile Val Glu Gly 
    450                 455                 460                 


Lys Gly Glu Asn Lys Gly Ser Leu Lys Val Gly Asp Gly Thr Val Ile 
465                 470                 475                 480 


Leu Lys Gln Gln Ala Asp Ala Asn Asn Lys Val Lys Ala Phe Ser Gln 
                485                 490                 495     


Val Gly Ile Val Ser Gly Arg Ser Thr Val Val Leu Asn Asp Asp Lys 
            500                 505                 510         


Gln Val Asp Pro Asn Ser Ile Tyr Phe Gly Phe Arg Gly Gly Arg Leu 
        515                 520                 525             


Asp Ala Asn Gly Asn Asn Leu Thr Phe Glu His Ile Arg Asn Ile Asp 
    530                 535                 540                 


Asp Gly Ala Arg Leu Val Asn His Asn Thr Ser Lys Thr Ser Thr Val 
545                 550                 555                 560 


Thr Ile Thr Gly Glu Ser Leu Ile Thr Asp Pro Asn Thr Ile Thr Pro 
                565                 570                 575     


Tyr Asn Ile Asp Ala Pro Asp Glu Asp Asn Pro Tyr Ala Phe Arg Arg 
            580                 585                 590         


Ile Lys Asp Gly Gly Gln Leu Tyr Leu Asn Leu Glu Asn Tyr Thr Tyr 
        595                 600                 605             


Tyr Ala Leu Arg Lys Gly Ala Ser Thr Arg Ser Glu Leu Pro Lys Asn 
    610                 615                 620                 


Ser Gly Glu Ser Asn Glu Asn Trp Leu Tyr Met Gly Lys Thr Ser Asp 
625                 630                 635                 640 


Glu Ala Lys Arg Asn Val Met Asn His Ile Asn Asn Glu Arg Met Asn 
                645                 650                 655     


Gly Phe Asn Gly Tyr Phe Gly Glu Glu Glu Gly Lys Asn Asn Gly Asn 
            660                 665                 670         


Leu Asn Val Thr Phe Lys Gly Lys Ser Glu Gln Asn Arg Phe Leu Leu 
        675                 680                 685             


Thr Gly Gly Thr Asn Leu Asn Gly Asp Leu Lys Val Glu Lys Gly Thr 
    690                 695                 700                 


Leu Phe Leu Ser Gly Arg Pro Thr Pro His Ala Arg Asp Ile Ala Gly 
705                 710                 715                 720 


Ile Ser Ser Thr Lys Lys Asp Gln His Phe Ala Glu Asn Asn Glu Val 
                725                 730                 735     


Val Val Glu Asp Asp Trp Ile Asn Arg Asn Phe Lys Ala Thr Asn Ile 
            740                 745                 750         


Asn Val Thr Asn Asn Ala Thr Leu Tyr Ser Gly Arg Asn Val Ala Asn 
        755                 760                 765             


Ile Thr Ser Asn Ile Thr Ala Ser Asp Asn Ala Lys Val His Ile Gly 
    770                 775                 780                 


Tyr Lys Ala Gly Asp Thr Val Cys Val Arg Ser Asp Tyr Thr Gly Tyr 
785                 790                 795                 800 


Val Thr Cys Thr Thr Asp Lys Leu Ser Asp Lys Ala Leu Asn Ser Phe 
                805                 810                 815     


Asn Ala Thr Asn Val Ser Gly Asn Val Asn Leu Ser Gly Asn Ala Asn 
            820                 825                 830         


Phe Val Leu Gly Lys Ala Asn Leu Phe Gly Thr Ile Ser Gly Thr Gly 
        835                 840                 845             


Asn Ser Gln Val Arg Leu Thr Glu Asn Ser His Trp His Leu Thr Gly 
    850                 855                 860                 


Asp Ser Asn Val Asn Gln Leu Asn Leu Asp Lys Gly His Ile His Leu 
865                 870                 875                 880 


Asn Ala Gln Asn Asp Ala Asn Lys Val Thr Thr Tyr Asn Thr Leu Thr 
                885                 890                 895     


Val Asn Ser Leu Ser Gly Asn Gly Ser Phe Tyr Tyr Leu Thr Asp Leu 
            900                 905                 910         


Ser Asn Lys Gln Gly Asp Lys Val Val Val Thr Lys Ser Ala Thr Gly 
        915                 920                 925             


Asn Phe Thr Leu Gln Val Ala Asp Lys Thr Gly Glu Pro Thr Lys Asn 
    930                 935                 940                 


Glu Leu Thr Leu Phe Asp Ala Ser Asn Ala Thr Arg Asn Asn Leu Asn 
945                 950                 955                 960 


Val Ser Leu Val Gly Asn Thr Val Asp Leu Gly Ala Trp Lys Tyr Lys 
                965                 970                 975     


Leu Arg Asn Val Asn Gly Arg Tyr Asp Leu Tyr Asn Pro Glu Val Glu 
            980                 985                 990         


Lys Arg Asn Gln Thr Val Asp Thr  Thr Asn Ile Thr Thr  Pro Asn Asn 
        995                 1000                 1005             


Ile Gln  Ala Asp Val Pro Ser  Val Pro Ser Asn Asn  Glu Glu Ile 
    1010                 1015                 1020             


Ala Arg  Val Glu Thr Pro Val  Pro Pro Pro Ala Pro  Ala Thr Pro 
    1025                 1030                 1035             


Ser Glu  Thr Thr Glu Thr Val  Ala Glu Asn Ser Lys  Gln Glu Ser 
    1040                 1045                 1050             


Lys Thr  Val Glu Lys Asn Glu  Gln Asp Ala Thr Glu  Thr Thr Ala 
    1055                 1060                 1065             


Gln Asn  Gly Glu Val Ala Glu  Glu Ala Lys Pro Ser  Val Lys Ala 
    1070                 1075                 1080             


Asn Thr  Gln Thr Asn Glu Val  Ala Gln Ser Gly Ser  Glu Thr Glu 
    1085                 1090                 1095             


Glu Thr  Gln Thr Thr Glu Ile  Lys Glu Thr Ala Lys  Val Glu Lys 
    1100                 1105                 1110             


Glu Glu  Lys Ala Lys Val Glu  Lys Glu Glu Lys Ala  Lys Val Glu 
    1115                 1120                 1125             


Lys Asp  Glu Ile Gln Glu Ala  Pro Gln Met Ala Ser  Glu Thr Ser 
    1130                 1135                 1140             


Pro Lys  Gln Ala Lys Pro Ala  Pro Lys Glu Val Ser  Thr Asp Thr 
    1145                 1150                 1155             


Lys Val  Glu Glu Thr Gln Val  Gln Ala Gln Pro Gln  Thr Gln Ser 
    1160                 1165                 1170             


Thr Thr  Val Ala Ala Ala Glu  Ala Thr Ser Pro Asn  Ser Lys Pro 
    1175                 1180                 1185             


Ala Glu  Glu Thr Gln Pro Ser  Glu Lys Thr Asn Ala  Glu Pro Val 
    1190                 1195                 1200             


Thr Pro  Val Val Ser Lys Asn  Gln Thr Glu Asn Thr  Thr Asp Gln 
    1205                 1210                 1215             


Pro Thr  Glu Arg Glu Lys Thr  Ala Lys Val Glu Thr  Glu Lys Thr 
    1220                 1225                 1230             


Gln Glu  Pro Pro Gln Val Ala  Ser Gln Ala Ser Pro  Lys Gln Glu 
    1235                 1240                 1245             


Gln Ser  Glu Thr Val Gln Pro  Gln Ala Val Leu Glu  Ser Glu Asn 
    1250                 1255                 1260             


Val Pro  Thr Val Asn Asn Ala  Glu Glu Val Gln Ala  Gln Leu Gln 
    1265                 1270                 1275             


Thr Gln  Thr Ser Ala Thr Val  Ser Thr Lys Gln Pro  Ala Pro Glu 
    1280                 1285                 1290             


Asn Ser  Ile Asn Thr Gly Ser  Ala Thr Ala Ile Thr  Glu Thr Ala 
    1295                 1300                 1305             


Glu Lys  Ser Asp Lys Pro Gln  Thr Glu Thr Ala Ala  Ser Thr Glu 
    1310                 1315                 1320             


Asp Ala  Ser Gln His Lys Ala  Asn Thr Val Ala Asp  Asn Ser Val 
    1325                 1330                 1335             


Ala Asn  Asn Ser Glu Ser Ser  Glu Pro Lys Ser Arg  Arg Arg Arg 
    1340                 1345                 1350             


Ser Ile  Ser Gln Pro Gln Glu  Thr Ser Ala Glu Glu  Thr Thr Ala 
    1355                 1360                 1365             


Ala Ser  Thr Asp Glu Thr Thr  Ile Ala Asp Asn Ser  Lys Arg Ser 
    1370                 1375                 1380             


Lys Pro  Asn Arg Arg Ser Arg  Arg Ser Val Arg Ser  Glu Pro Thr 
    1385                 1390                 1395             


Val Thr  Asn Gly Ser Asp Arg  Ser Thr Val Ala Leu  Arg Asp Leu 
    1400                 1405                 1410             


Thr Ser  Thr Asn Thr Asn Ala  Val Ile Ser Asp Ala  Met Ala Lys 
    1415                 1420                 1425             


Ala Gln  Phe Val Ala Leu Asn  Val Gly Lys Ala Val  Ser Gln His 
    1430                 1435                 1440             


Ile Ser  Gln Leu Glu Met Asn  Asn Glu Gly Gln Tyr  Asn Val Trp 
    1445                 1450                 1455             


Val Ser  Asn Thr Ser Met Asn  Glu Asn Tyr Ser Ser  Ser Gln Tyr 
    1460                 1465                 1470             


Arg Arg  Phe Ser Ser Lys Ser  Thr Gln Thr Gln Leu  Gly Trp Asp 
    1475                 1480                 1485             


Gln Thr  Ile Ser Asn Asn Val  Gln Leu Gly Gly Val  Phe Thr Tyr 
    1490                 1495                 1500             


Val Arg  Asn Ser Asn Asn Phe  Asp Lys Ala Ser Ser  Lys Asn Thr 
    1505                 1510                 1515             


Leu Ala  Gln Val Asn Phe Tyr  Ser Lys Tyr Tyr Ala  Asp Asn His 
    1520                 1525                 1530             


Trp Tyr  Leu Gly Ile Asp Leu  Gly Tyr Gly Lys Phe  Gln Ser Asn 
    1535                 1540                 1545             


Leu Lys  Thr Asn His Asn Ala  Lys Phe Ala Arg His  Thr Ala Gln 
    1550                 1555                 1560             


Phe Gly  Leu Thr Ala Gly Lys  Ala Phe Asn Leu Gly  Asn Phe Gly 
    1565                 1570                 1575             


Ile Thr  Pro Ile Val Gly Val  Arg Tyr Ser Tyr Leu  Ser Asn Ala 
    1580                 1585                 1590             


Asn Phe  Ala Leu Ala Lys Asp  Arg Ile Lys Val Asn  Pro Ile Ser 
    1595                 1600                 1605             


Val Lys  Thr Ala Phe Ala Gln  Val Asp Leu Ser Tyr  Thr Tyr His 
    1610                 1615                 1620             


Leu Gly  Glu Phe Ser Val Thr  Pro Ile Leu Ser Ala  Arg Tyr Asp 
    1625                 1630                 1635             


Thr Asn  Gln Gly Ser Gly Lys  Ile Asn Val Asn Gln  Tyr Asp Phe 
    1640                 1645                 1650             


Ala Tyr  Asn Val Glu Asn Gln  Gln Gln Tyr Asn Ala  Gly Leu Lys 
    1655                 1660                 1665             


Leu Lys  Tyr His Asn Val Lys  Leu Ser Leu Ile Gly  Gly Leu Thr 
    1670                 1675                 1680             


Lys Ala  Lys Gln Ala Glu Lys  Gln Lys Thr Ala Glu  Leu Lys Leu 
    1685                 1690                 1695             


Ser Phe  Ser Phe 
    1700         


<210>  13
<211>  5085
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(5085)
<223>  encodes IgA1 protease from Rd strain

<400>  13
atgctaaata aaaaattcaa actcaatttt attgcgctta ctgtcgccta cgcattaacc       60

ccttatacag aagctgcgtt agtgagagac gatgtggatt atcaaatatt tcgtgatttt      120

gcagaaaata aagggagatt ttctgttggt gcaacaaatg tggaagtgag agataaaaat      180

aaccactctt taggcaatgt tttacctaat ggcattccga tgattgattt tagtgttgtg      240

gatgtagata aacgcatcgc cacattgata aatccacaat atgtagtagg tgtaaaacac      300

gttagtaacg gcgtgagtga actacatttt gggaacttaa atggcaatat gaataatggc      360

aatgctaaat cgcaccgaga tgtatcttca gaagaaaata gatatttttc cgttgagaaa      420

aatgagtatc caactaaatt gaatggaaaa gcagtaacta ctgaagatca aactcaaaaa      480

cgccgtgaag actactatat gccacgtctt gataaatttg ttaccgaagt tgcaccaata      540

gaggcttcaa ctgcaagtag tgatgctggc acatataatg atcagaataa atatcctgct      600

tttgtaagac taggaagtgg tagtcaattt atttataaaa aaggagataa ttacagctta      660

attttaaata atcatgaggt tggaggcaat aatcttaaat tggtgggcga tgcctatacc      720

tatggtattg caggcacacc ttataaagta aaccacgaaa ataatggact aattggtttt      780

ggcaattcaa aagaggaaca cagcgatcca aaaggaatat tatctcaaga tccgcttacc      840

aattatgctg ttttaggcga cagtggctcc ccattatttg tatatgatag agaaaaagga      900

aaatggcttt ttcttgggtc ttatgatttt tgggcaggtt ataacaaaaa atcttggcaa      960

gaatggaata tttataaacc tgaatttgca aaaactgttc tagataaaga tactgcaggt     1020

tctttaactg gttctaacac ccaatacaat tggaatccta ctggcaaaac aagcgttatt     1080

tctaatggtt ctgaatctct aaatgttgat ttattcgata gtagtcagga tactgactct     1140

aagaagaaca atcacggaaa aagtgtgact cttagaggaa gtggaacgct taccttaaat     1200

aataatatcg atcaaggcgc aggcggcttg ttctttgaag gagattatga agttaaaggc     1260

acttctgata gtaccacttg gaaaggagct ggcgtttctg ttgctgatgg aaaaacagta     1320

acgtggaaag tacataaccc gaaatctgat cgtttagcta aaatcggcaa aggaacatta     1380

attgtagaag gaaagggaga aaataaaggt tcgctaaaag tgggcgatgg tactgttatc     1440

ttaaaacaac aagctgatgc caataataaa gttaaagcct tttcacaagt aggtatagta     1500

agtggtcgct caactgttgt acttaatgat gataagcaag tagatccaaa ttccatttac     1560

tttggcttta gaggtggtcg attagatgcc aatggcaata atctcacttt tgaacatatc     1620

cgtaatattg atgatggcgc aagactagta aatcacaata ccagcaaaac ctctactgta     1680

acaattactg gggaaagtct aattacagat ccaaatacaa ttactccata taatatagac     1740

gcaccagatg aagataatcc ttatgccttt cgacggatta aagatggagg acagctctat     1800

ttaaatttgg aaaattacac ttattatgcg ttaagaaaag gtgcgagcac tcgttcagaa     1860

ttacctaaaa atagtggcga aagcaatgaa aattggctat atatgggtaa aacttccgat     1920

gaagccaaaa gaaatgtaat gaaccatatc aacaacgagc gtatgaatgg ctttaacggt     1980

tattttggcg aggaagaggg taaaaataac ggtaatctaa atgtgacttt taaaggcaaa     2040

agtgagcaaa atcgcttttt attaacaggc ggaacaaacc ttaatggcga tttaaaggtt     2100

gaaaaaggca cattattcct ttctggcaga ccaacaccgc acgcaagaga tattgcaggt     2160

atttcttcga caaaaaaaga tcaacacttt gctgaaaata atgaagtggt agtagaagat     2220

gactggatta accgcaattt taaagcaaca aatattaatg taaccaataa cgcaaccctt     2280

tattcaggtc gcaatgttgc aaacattact tcaaatatca cagcttctga taatgcaaaa     2340

gtacatattg gctataaagc aggcgatacc gtttgtgtac gttctgacta tacgggctat     2400

gtgacttgca ctactgacaa gttatccgat aaagccctta atagctttaa cgccaccaat     2460

gtatctggca atgtaaattt atcaggtaat gcaaactttg tcttaggcaa agctaactta     2520

ttcggcacaa ttagcggcac gggaaatagc caagtacgtt taaccgaaaa tagccattgg     2580

catttaacag gcgatagcaa tgttaatcag ttaaatttag acaaggggca tattcattta     2640

aatgcacaaa acgatgcaaa taaagtaact acatataaca cgctgactgt gaatagctta     2700

tcaggtaacg gttctttcta ttatttaact gatctttcca ataaacaagg cgacaaagtt     2760

gttgtaacta aatccgccac aggtaacttt acattacaag tggcagataa aacaggcgag     2820

cctacaaaaa atgaactcac gctttttgat gcgtcaaatg ctacaagaaa taatttgaat     2880

gtgtcattag ttgggaatac cgttgattta ggtgcttgga aatataaatt acgtaatgtt     2940

aatggacgtt acgatttgta taacccagag gtggaaaaaa gaaatcaaac tgtcgatacg     3000

acaaatatca caacacctaa taatattcaa gctgatgtgc ctagcgtacc aagtaacaat     3060

gaagaaatag cccgtgttga aacaccagtt ccaccacctg cgcctgctac accatcagag     3120

acaactgaaa cagtggctga aaatagtaag caagaaagta aaacagtaga gaaaaacgag     3180

caagacgcaa ccgagacaac agctcaaaat ggagaagttg cagaagaagc taaaccaagt     3240

gtaaaagcta atactcaaac aaatgaagtg gctcaaagtg gaagtgaaac cgaggaaact     3300

caaacgactg aaataaaaga aacagctaaa gtagaaaaag aggaaaaggc taaagtagaa     3360

aaagatgaaa ttcaagaagc acctcaaatg gcttctgaaa cgtctccgaa acaagcaaag     3420

cctgctccta aagaagtttc aactgatacg aaagtagaag aaactcaagt tcaagctcaa     3480

ccgcaaacac aatcgacaac tgttgctgcg gcagaggcaa cttcgccaaa cagtaaacca     3540

gcggaagaaa ctcaaccaag tgaaaaaact aacgctgaac ctgtaacgcc tgtagtatca     3600

aaaaatcaaa cagaaaatac gaccgaccaa ccaacagaaa gagagaaaac ggctaaagta     3660

gaaacagaga aaactcaaga accccctcaa gtggcttctc aagcgtctcc gaaacaggaa     3720

cagtctgaaa ctgttcaacc gcaagcagtg cttgaaagtg aaaatgttcc gactgttaat     3780

aatgcagaag aagttcaagc tcaactgcaa acacaaacaa gtgcaacagt aagcactaaa     3840

caacctgcac cagagaattc aataaatact ggatctgcaa ccgcaataac agaaactgct     3900

gaaaaatccg ataaaccaca aacggaaact gcggcttcga ctgaagatgc tagtcagcat     3960

aaagcgaata ctgttgcgga taattctgta gcaaataatt cagaaagcag tgatccaaag     4020

agtagacgta gaagaagtat tagccagcct caagagactt ctgctgaaga aacaacagca     4080

gcttctactg acgaaacaac aatagctgat aattcaaaac gcagtaagcc aaatcgtaga     4140

agtagaagaa gtgttcgctc ggaaccaact gttacaaatg gcagcgatcg ttctacagta     4200

gcattgcgcg atctcacaag tacaaacaca aatgcggtaa tttctgatgc aatggcaaaa     4260

gcacaatttg ttgcattaaa tgtggggaaa gcagtttctc aacatattag ccagttagaa     4320

atgaataacg aggggcaata taacgtttgg gtatctaata cttcaatgaa cgaaaattat     4380

tcctcaagtc aatatcgtcg ttttagttct aaaagtacgc aaactcaact tggttgggat     4440

caaacaatct caaacaatgt tcagttaggt ggcgtgttta cttatgttcg caatagtaac     4500

aactttgata aggcaagcag taaaaatact ctagcacaag ttaatttcta ttctaaatat     4560

tatgcggata atcattggta tttgggcatt gatttaggct acggcaagtt ccaaagcaac     4620

ctaaaaacca atcataatgc gaaatttgct cgccatactg cacaatttgg tttaaccgca     4680

ggcaaagcat ttaatcttgg caattttggt attacgccaa tagtaggcgt gcgttatagc     4740

tatttatcaa acgctaattt tgcattagct aaagatcgca ttaaagtaaa tccaatatct     4800

gtcaaaacag cctttgctca agttgattta agttatactt atcacttagg cgagttttcc     4860

gttacgccaa ttttgtctgc tcgatatgat acaaatcaag gcagcggaaa aattaatgta     4920

aatcaatatg attttgctta caacgtggaa aaccaacagc aatataacgc agggcttaaa     4980

ttgaaatatc ataatgtgaa attaagtcta ataggcggat taacaaaagc gaaacaagcg     5040

gaaaaacaaa aaactgcaga attaaaacta agttttagtt tttaa                     5085


<210>  14
<211>  1694
<212>  PRT
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(1694)
<223>  full-length precursor IgA1 protease from Rd strain

<400>  14

Met Leu Asn Lys Lys Phe Lys Leu Asn Phe Ile Ala Leu Thr Val Ala 
1               5                   10                  15      


Tyr Ala Leu Thr Pro Tyr Thr Glu Ala Ala Leu Val Arg Asp Asp Val 
            20                  25                  30          


Asp Tyr Gln Ile Phe Arg Asp Phe Ala Glu Asn Lys Gly Arg Phe Ser 
        35                  40                  45              


Val Gly Ala Thr Asn Val Glu Val Arg Asp Lys Asn Asn His Ser Leu 
    50                  55                  60                  


Gly Asn Val Leu Pro Asn Gly Ile Pro Met Ile Asp Phe Ser Val Val 
65                  70                  75                  80  


Asp Val Asp Lys Arg Ile Ala Thr Leu Ile Asn Pro Gln Tyr Val Val 
                85                  90                  95      


Gly Val Lys His Val Ser Asn Gly Val Ser Glu Leu His Phe Gly Asn 
            100                 105                 110         


Leu Asn Gly Asn Met Asn Asn Gly Asn Ala Lys Ser His Arg Asp Val 
        115                 120                 125             


Ser Ser Glu Glu Asn Arg Tyr Phe Ser Val Glu Lys Asn Glu Tyr Pro 
    130                 135                 140                 


Thr Lys Leu Asn Gly Lys Ala Val Thr Thr Glu Asp Gln Thr Gln Lys 
145                 150                 155                 160 


Arg Arg Glu Asp Tyr Tyr Met Pro Arg Leu Asp Lys Phe Val Thr Glu 
                165                 170                 175     


Val Ala Pro Ile Glu Ala Ser Thr Ala Ser Ser Asp Ala Gly Thr Tyr 
            180                 185                 190         


Asn Asp Gln Asn Lys Tyr Pro Ala Phe Val Arg Leu Gly Ser Gly Ser 
        195                 200                 205             


Gln Phe Ile Tyr Lys Lys Gly Asp Asn Tyr Ser Leu Ile Leu Asn Asn 
    210                 215                 220                 


His Glu Val Gly Gly Asn Asn Leu Lys Leu Val Gly Asp Ala Tyr Thr 
225                 230                 235                 240 


Tyr Gly Ile Ala Gly Thr Pro Tyr Lys Val Asn His Glu Asn Asn Gly 
                245                 250                 255     


Leu Ile Gly Phe Gly Asn Ser Lys Glu Glu His Ser Asp Pro Lys Gly 
            260                 265                 270         


Ile Leu Ser Gln Asp Pro Leu Thr Asn Tyr Ala Val Leu Gly Asp Ser 
        275                 280                 285             


Gly Ser Pro Leu Phe Val Tyr Asp Arg Glu Lys Gly Lys Trp Leu Phe 
    290                 295                 300                 


Leu Gly Ser Tyr Asp Phe Trp Ala Gly Tyr Asn Lys Lys Ser Trp Gln 
305                 310                 315                 320 


Glu Trp Asn Ile Tyr Lys Pro Glu Phe Ala Lys Thr Val Leu Asp Lys 
                325                 330                 335     


Asp Thr Ala Gly Ser Leu Thr Gly Ser Asn Thr Gln Tyr Asn Trp Asn 
            340                 345                 350         


Pro Thr Gly Lys Thr Ser Val Ile Ser Asn Gly Ser Glu Ser Leu Asn 
        355                 360                 365             


Val Asp Leu Phe Asp Ser Ser Gln Asp Thr Asp Ser Lys Lys Asn Asn 
    370                 375                 380                 


His Gly Lys Ser Val Thr Leu Arg Gly Ser Gly Thr Leu Thr Leu Asn 
385                 390                 395                 400 


Asn Asn Ile Asp Gln Gly Ala Gly Gly Leu Phe Phe Glu Gly Asp Tyr 
                405                 410                 415     


Glu Val Lys Gly Thr Ser Asp Ser Thr Thr Trp Lys Gly Ala Gly Val 
            420                 425                 430         


Ser Val Ala Asp Gly Lys Thr Val Thr Trp Lys Val His Asn Pro Lys 
        435                 440                 445             


Ser Asp Arg Leu Ala Lys Ile Gly Lys Gly Thr Leu Ile Val Glu Gly 
    450                 455                 460                 


Lys Gly Glu Asn Lys Gly Ser Leu Lys Val Gly Asp Gly Thr Val Ile 
465                 470                 475                 480 


Leu Lys Gln Gln Ala Asp Ala Asn Asn Lys Val Lys Ala Phe Ser Gln 
                485                 490                 495     


Val Gly Ile Val Ser Gly Arg Ser Thr Val Val Leu Asn Asp Asp Lys 
            500                 505                 510         


Gln Val Asp Pro Asn Ser Ile Tyr Phe Gly Phe Arg Gly Gly Arg Leu 
        515                 520                 525             


Asp Ala Asn Gly Asn Asn Leu Thr Phe Glu His Ile Arg Asn Ile Asp 
    530                 535                 540                 


Asp Gly Ala Arg Leu Val Asn His Asn Thr Ser Lys Thr Ser Thr Val 
545                 550                 555                 560 


Thr Ile Thr Gly Glu Ser Leu Ile Thr Asp Pro Asn Thr Ile Thr Pro 
                565                 570                 575     


Tyr Asn Ile Asp Ala Pro Asp Glu Asp Asn Pro Tyr Ala Phe Arg Arg 
            580                 585                 590         


Ile Lys Asp Gly Gly Gln Leu Tyr Leu Asn Leu Glu Asn Tyr Thr Tyr 
        595                 600                 605             


Tyr Ala Leu Arg Lys Gly Ala Ser Thr Arg Ser Glu Leu Pro Lys Asn 
    610                 615                 620                 


Ser Gly Glu Ser Asn Glu Asn Trp Leu Tyr Met Gly Lys Thr Ser Asp 
625                 630                 635                 640 


Glu Ala Lys Arg Asn Val Met Asn His Ile Asn Asn Glu Arg Met Asn 
                645                 650                 655     


Gly Phe Asn Gly Tyr Phe Gly Glu Glu Glu Gly Lys Asn Asn Gly Asn 
            660                 665                 670         


Leu Asn Val Thr Phe Lys Gly Lys Ser Glu Gln Asn Arg Phe Leu Leu 
        675                 680                 685             


Thr Gly Gly Thr Asn Leu Asn Gly Asp Leu Lys Val Glu Lys Gly Thr 
    690                 695                 700                 


Leu Phe Leu Ser Gly Arg Pro Thr Pro His Ala Arg Asp Ile Ala Gly 
705                 710                 715                 720 


Ile Ser Ser Thr Lys Lys Asp Gln His Phe Ala Glu Asn Asn Glu Val 
                725                 730                 735     


Val Val Glu Asp Asp Trp Ile Asn Arg Asn Phe Lys Ala Thr Asn Ile 
            740                 745                 750         


Asn Val Thr Asn Asn Ala Thr Leu Tyr Ser Gly Arg Asn Val Ala Asn 
        755                 760                 765             


Ile Thr Ser Asn Ile Thr Ala Ser Asp Asn Ala Lys Val His Ile Gly 
    770                 775                 780                 


Tyr Lys Ala Gly Asp Thr Val Cys Val Arg Ser Asp Tyr Thr Gly Tyr 
785                 790                 795                 800 


Val Thr Cys Thr Thr Asp Lys Leu Ser Asp Lys Ala Leu Asn Ser Phe 
                805                 810                 815     


Asn Ala Thr Asn Val Ser Gly Asn Val Asn Leu Ser Gly Asn Ala Asn 
            820                 825                 830         


Phe Val Leu Gly Lys Ala Asn Leu Phe Gly Thr Ile Ser Gly Thr Gly 
        835                 840                 845             


Asn Ser Gln Val Arg Leu Thr Glu Asn Ser His Trp His Leu Thr Gly 
    850                 855                 860                 


Asp Ser Asn Val Asn Gln Leu Asn Leu Asp Lys Gly His Ile His Leu 
865                 870                 875                 880 


Asn Ala Gln Asn Asp Ala Asn Lys Val Thr Thr Tyr Asn Thr Leu Thr 
                885                 890                 895     


Val Asn Ser Leu Ser Gly Asn Gly Ser Phe Tyr Tyr Leu Thr Asp Leu 
            900                 905                 910         


Ser Asn Lys Gln Gly Asp Lys Val Val Val Thr Lys Ser Ala Thr Gly 
        915                 920                 925             


Asn Phe Thr Leu Gln Val Ala Asp Lys Thr Gly Glu Pro Thr Lys Asn 
    930                 935                 940                 


Glu Leu Thr Leu Phe Asp Ala Ser Asn Ala Thr Arg Asn Asn Leu Asn 
945                 950                 955                 960 


Val Ser Leu Val Gly Asn Thr Val Asp Leu Gly Ala Trp Lys Tyr Lys 
                965                 970                 975     


Leu Arg Asn Val Asn Gly Arg Tyr Asp Leu Tyr Asn Pro Glu Val Glu 
            980                 985                 990         


Lys Arg Asn Gln Thr Val Asp Thr  Thr Asn Ile Thr Thr  Pro Asn Asn 
        995                 1000                 1005             


Ile Gln  Ala Asp Val Pro Ser  Val Pro Ser Asn Asn  Glu Glu Ile 
    1010                 1015                 1020             


Ala Arg  Val Glu Thr Pro Val  Pro Pro Pro Ala Pro  Ala Thr Pro 
    1025                 1030                 1035             


Ser Glu  Thr Thr Glu Thr Val  Ala Glu Asn Ser Lys  Gln Glu Ser 
    1040                 1045                 1050             


Lys Thr  Val Glu Lys Asn Glu  Gln Asp Ala Thr Glu  Thr Thr Ala 
    1055                 1060                 1065             


Gln Asn  Gly Glu Val Ala Glu  Glu Ala Lys Pro Ser  Val Lys Ala 
    1070                 1075                 1080             


Asn Thr  Gln Thr Asn Glu Val  Ala Gln Ser Gly Ser  Glu Thr Glu 
    1085                 1090                 1095             


Glu Thr  Gln Thr Thr Glu Ile  Lys Glu Thr Ala Lys  Val Glu Lys 
    1100                 1105                 1110             


Glu Glu  Lys Ala Lys Val Glu  Lys Asp Glu Ile Gln  Glu Ala Pro 
    1115                 1120                 1125             


Gln Met  Ala Ser Glu Thr Ser  Pro Lys Gln Ala Lys  Pro Ala Pro 
    1130                 1135                 1140             


Lys Glu  Val Ser Thr Asp Thr  Lys Val Glu Glu Thr  Gln Val Gln 
    1145                 1150                 1155             


Ala Gln  Pro Gln Thr Gln Ser  Thr Thr Val Ala Ala  Ala Glu Ala 
    1160                 1165                 1170             


Thr Ser  Pro Asn Ser Lys Pro  Ala Glu Glu Thr Gln  Pro Ser Glu 
    1175                 1180                 1185             


Lys Thr  Asn Ala Glu Pro Val  Thr Pro Val Val Ser  Lys Asn Gln 
    1190                 1195                 1200             


Thr Glu  Asn Thr Thr Asp Gln  Pro Thr Glu Arg Glu  Lys Thr Ala 
    1205                 1210                 1215             


Lys Val  Glu Thr Glu Lys Thr  Gln Glu Pro Pro Gln  Val Ala Ser 
    1220                 1225                 1230             


Gln Ala  Ser Pro Lys Gln Glu  Gln Ser Glu Thr Val  Gln Pro Gln 
    1235                 1240                 1245             


Ala Val  Leu Glu Ser Glu Asn  Val Pro Thr Val Asn  Asn Ala Glu 
    1250                 1255                 1260             


Glu Val  Gln Ala Gln Leu Gln  Thr Gln Thr Ser Ala  Thr Val Ser 
    1265                 1270                 1275             


Thr Lys  Gln Pro Ala Pro Glu  Asn Ser Ile Asn Thr  Gly Ser Ala 
    1280                 1285                 1290             


Thr Ala  Ile Thr Glu Thr Ala  Glu Lys Ser Asp Lys  Pro Gln Thr 
    1295                 1300                 1305             


Glu Thr  Ala Ala Ser Thr Glu  Asp Ala Ser Gln His  Lys Ala Asn 
    1310                 1315                 1320             


Thr Val  Ala Asp Asn Ser Val  Ala Asn Asn Ser Glu  Ser Ser Asp 
    1325                 1330                 1335             


Pro Lys  Ser Arg Arg Arg Arg  Ser Ile Ser Gln Pro  Gln Glu Thr 
    1340                 1345                 1350             


Ser Ala  Glu Glu Thr Thr Ala  Ala Ser Thr Asp Glu  Thr Thr Ile 
    1355                 1360                 1365             


Ala Asp  Asn Ser Lys Arg Ser  Lys Pro Asn Arg Arg  Ser Arg Arg 
    1370                 1375                 1380             


Ser Val  Arg Ser Glu Pro Thr  Val Thr Asn Gly Ser  Asp Arg Ser 
    1385                 1390                 1395             


Thr Val  Ala Leu Arg Asp Leu  Thr Ser Thr Asn Thr  Asn Ala Val 
    1400                 1405                 1410             


Ile Ser  Asp Ala Met Ala Lys  Ala Gln Phe Val Ala  Leu Asn Val 
    1415                 1420                 1425             


Gly Lys  Ala Val Ser Gln His  Ile Ser Gln Leu Glu  Met Asn Asn 
    1430                 1435                 1440             


Glu Gly  Gln Tyr Asn Val Trp  Val Ser Asn Thr Ser  Met Asn Glu 
    1445                 1450                 1455             


Asn Tyr  Ser Ser Ser Gln Tyr  Arg Arg Phe Ser Ser  Lys Ser Thr 
    1460                 1465                 1470             


Gln Thr  Gln Leu Gly Trp Asp  Gln Thr Ile Ser Asn  Asn Val Gln 
    1475                 1480                 1485             


Leu Gly  Gly Val Phe Thr Tyr  Val Arg Asn Ser Asn  Asn Phe Asp 
    1490                 1495                 1500             


Lys Ala  Ser Ser Lys Asn Thr  Leu Ala Gln Val Asn  Phe Tyr Ser 
    1505                 1510                 1515             


Lys Tyr  Tyr Ala Asp Asn His  Trp Tyr Leu Gly Ile  Asp Leu Gly 
    1520                 1525                 1530             


Tyr Gly  Lys Phe Gln Ser Asn  Leu Lys Thr Asn His  Asn Ala Lys 
    1535                 1540                 1545             


Phe Ala  Arg His Thr Ala Gln  Phe Gly Leu Thr Ala  Gly Lys Ala 
    1550                 1555                 1560             


Phe Asn  Leu Gly Asn Phe Gly  Ile Thr Pro Ile Val  Gly Val Arg 
    1565                 1570                 1575             


Tyr Ser  Tyr Leu Ser Asn Ala  Asn Phe Ala Leu Ala  Lys Asp Arg 
    1580                 1585                 1590             


Ile Lys  Val Asn Pro Ile Ser  Val Lys Thr Ala Phe  Ala Gln Val 
    1595                 1600                 1605             


Asp Leu  Ser Tyr Thr Tyr His  Leu Gly Glu Phe Ser  Val Thr Pro 
    1610                 1615                 1620             


Ile Leu  Ser Ala Arg Tyr Asp  Thr Asn Gln Gly Ser  Gly Lys Ile 
    1625                 1630                 1635             


Asn Val  Asn Gln Tyr Asp Phe  Ala Tyr Asn Val Glu  Asn Gln Gln 
    1640                 1645                 1650             


Gln Tyr  Asn Ala Gly Leu Lys  Leu Lys Tyr His Asn  Val Lys Leu 
    1655                 1660                 1665             


Ser Leu  Ile Gly Gly Leu Thr  Lys Ala Lys Gln Ala  Glu Lys Gln 
    1670                 1675                 1680             


Lys Thr  Ala Glu Leu Lys Leu  Ser Phe Ser Phe 
    1685                 1690                 


<210>  15
<211>  231
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(231)
<223>  partial nucleotide sequence for IgA1 protease from 7768 strain

<400>  15
tgcgcctgct acaccatcag agacaactct aaaacagtgg ctgaaaataa tccgcaagaa       60

agtgaaacag tagagaaaaa cgagcaagac gcaaccgaga caacagctca aaatggagaa      120

attacaaaag aagctaaacc aagtgtaaaa gctaacactc aaacaaatga agtggctcaa      180

agtggaagtg aaaccgagga aactcaaacg actgaaacaa aagaaacagc t               231


<210>  16
<211>  235
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(235)
<223>  partial nucleotide sequence for IgA1 protease from 6338 strain

<400>  16
atcagagaca actaaaacag tggctgaaaa tagtaagcaa gaaagtaaaa caatagcgaa       60

aaacgagcaa gacgcaaccg agacaagatc tcaaaatgat gaagttgcaa aagaagctaa      120

accaagtgta gaagctnatc ctcaaacaaa tgaagtggct caaagtggaa gcaaaaccga      180

ggaaactcaa acgactgaaa caaaagaaac agctaaagta gaaaaagaga aaacg           235


<210>  17
<211>  749
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(749)
<223>  partial nucleotide sequence for IgA1 protease from 2509 strain

<400>  17
aaatcaaaat ggttttaata gaacaggaac agggtattcg attgtagctg atacgaaaga       60

aacggttatg attacgcata aatacgataa tggagaaatt ttcaaggaga aagtggtatt      120

caaatcagaa tttactgagg atattgataa atacaaagaa aacagacctg atctgacagc      180

cactggaatg aaatctactg gaacaaattc ctatgctatt acttataaga cagtaacagc      240

tgaagaagct ccaaaagaac cactaaaaat ggataacccg catacattat ctattgaaaa      300

taaaaaacca gttgctgttg ttaaaccaga agaaactcca aatggtgtta cgtctcacaa      360

gcattctgaa actgatccaa aatctgatac cgcaacacaa gctgataatc caaattcaga      420

aagtgttcca tcagagacaa ttgaaaaagt ggctgaaaat agtccgcaag aaagtgaaac      480

agtagcgaaa aacgagcaag aagccgccga aacaacacct caaaatgatg aagttgcaaa      540

agctcaatca agtgcagaaa ctaaggctaa aacaaatgaa gtggctcaaa gtggaagtga      600

agccgaggaa actcaagagg ctgaaactac tcgcgagcct gaaataaatt ctactgaagt      660

actgaagaaa cagcagtgga aaattatcca acaagcagtg aaccaaagag tagacgtaga      720

agaaatgtta gctcgtcttc aaataatat                                        749


<210>  18
<211>  5719
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(5719)
<223>  encodes IgA1 protease from aegyptius strain

<400>  18
accgccatta cgcaaagaca actaaaagaa atgcaagttg aaaataaaaa aatgttttct       60

gttcataatg gcatcattaa cgccttaaat tagccaaaag tgcggtggaa aatacgccaa      120

ttttttaaaa aatatcaaaa attattatca ttacctcgta aatgtaattc aagttttgag      180

cgatttatgc tataaagctc gctcattata aaaatgaaga caacttgcaa actatcgacg      240

caacacagcc aagatttgaa tcaacttgta accgtatatc aaattgtgtc ctatcaaatc      300

tactttttaa acttaattaa taaggacagc ttctatgcta aataaaaaat tcaaactcaa      360

ttttattgcg cttactgtcg cctacgcatt aaccccttat acagaagctg cgttagtgag      420

agacgatgtg gattatcaaa tatttcgtga ttttgcagaa aataaaggga gattttctgt      480

tggtgcaaca aatgtggaag tgagagataa aaataaccac tctttaggca atgctttacc      540

taatggcatt ccgatgattg attttagtgt tgtggatgtg aataaacgta ttggtacatt      600

agtcgatccg caatatattg tgagcgtaaa acacgcacat caatatatga atgactttta      660

ttttggacat tataacggac accgtgatgt ttctaatgat gaaaataaat atagtgtagt      720

cacacaaaat aatgttaatt caagtgaaaa gtgggatgtt aataagcgat tagacgacta      780

taatatgcct cgtttaaata aatttgttac cgaggttgca ccaactaccc ctacattagc      840

aggagacgat ttagaaacct ataaagataa agaaaaatat ccgtcctttg tacgagtagg      900

tgctggtcgc caattagtat atgaaaaagg aagccgccat gtagaaggta atgaacatgg      960

agaggattta aaagatcttt cagttgcata taattatgct atcggtggta caccttatga     1020

agggattaat attgatcctt cccaaagtaa aaaaggactt atcggttttg gagatagtcg     1080

caaagatcac gttattgata ctaaaatttt actctcccaa gctcccctaa ccaactacgg     1140

cgtattaggc gatagtggtt cccctttatt tgcttttgat aaacaacaaa acaaatggat     1200

ttttatcggg ccttatactt attgggcagg ctatgagaaa aaatcttggc aagaatggaa     1260

tatttataaa actacttttg ctgatggtat aaaaaaccga gataacgcta aacctgtgcc     1320

tttctctaac aaagaatatc gttggacaaa cactacaaat catcaaagtg aaataaaaaa     1380

cactgatcat actattactg taacactccc ctcagatcca gatcgacttg ttaattatca     1440

gaaagaagaa aacaagaata ctgggcaaaa tgtaattttt gaaggaaatg gtaattctaa     1500

aaatacactt gttttagaaa ataatatcaa tcaaggtgct ggcggtttat tctttaaagg     1560

caactatgaa gttaaaggaa caactgacaa tattacttgg gtaggcggcg gaattgatgt     1620

tgctgaagga aaaacagtca cgtggaaagt acataatcct gaaaaagacc atttagctaa     1680

aattggtaaa gggaagctaa ttgttgaagg caaaggagat aataaaggtt cgctaaaagt     1740

gggcgatggc acagtagttt taaaacaaca aacaactaca ggacaacacg cttttgcttc     1800

tgtagggatt gtaagtggtc gctcaactgt tgtgcttaat gatgataaac aagtagatcc     1860

aaattcaatt tactttggtt ttagaggcgg tcgattagac ttaaacggta attcacttac     1920

atttgaccac atcagaaata ttgatgatgg ggcaagacta gttaatcata atatgactaa     1980

tgcctcaaat ataacgatta ctggggaaag tctaattaca gatccaaaga aaattaatcc     2040

atattatata aaagcacgag aggaagataa tccttatgcc tttcgatgga tcaaagatgg     2100

agaacagctc tattttaatc tagaaaatta cacttattat gcgttaagaa aaggtggtaa     2160

agctaactcg caacttcctt ataatgacaa agaaagcaac gaaaactggc tatatatggg     2220

taaaaatgcc gatgaagcca aaagaaatgt aatgaagcat atcaacaacg agcgtatgaa     2280

tggctttaac ggttattttg gtgaggaaga aggtaaagat aacggtaatc taaacgttac     2340

ctttaaaggt aaaaccgagc aaaatcgctt tttattaaca ggcggaacaa accttaatgg     2400

caatttaaag gttgaacaag gtacattatt cctttctggc agaccaacac cgcacgcaag     2460

agatattgcg ggtatttctt caacaaagaa agactcacac tttgctgaaa ataatgaagt     2520

ggtggtagaa gacgactgga ttaaccgcaa ttttaaagca actacaatga acgtgactgg     2580

caatgcctca ctttattcag gacgcaatgt tgaaagcatt acttcaaata tcacagcttc     2640

tagcaaagca caagtgcata tcggctataa aaaaggcgac accgtttgtg tgcgttctga     2700

ctatacgggc tatgtgactt gccataatgg cgatttatcg gaaaaagccc ttaatagctt     2760

taacgccact aatgtatttg gtaatgtaaa tttatcaggt aatgcaaact ttaccttagg     2820

caaagctaat ttgcatggat caattcaggc aggtggaaac agccaagtgc atttaaccga     2880

aaatagccat tggtatttaa caggcgatag taatgttcat cagttagatt taaaaaatgg     2940

acatattcat ttaaattcag ctgataataa aaataatgtg acaaaatata atacgctcaa     3000

tattagcaat ttatcaggta acggttcttt ctattattta actgatcttt ctaaaaatca     3060

gggcgataaa gttgttgtaa ccaaatccgc caaaggtaac tttacattac aagtagcaga     3120

taaaacaggc gaacctacaa aaaatgaact cacgcttttt gatgcttcaa atgctacaag     3180

aagtaattta gtagtgacat tagcaaatgg cagtgttgat cgaggtgctt ggaaatacaa     3240

attacgtgaa aacaatggac gttacgattt gtataaccca gaagtagaaa gaagacatca     3300

aactgtcgat acgccaagtg ttgaaatgcc taatgatatg caagctgatg cacctagcgc     3360

accaagcaac aatgaagaaa tagcccgtgt tgatgcaccc gttccaccac cagcaccacc     3420

tgcacctgct actggatcag caatggcaaa agagcaacca aaaactcgtc ctgcagaaac     3480

cgctcaacca acaatggaag agacaaaggc tgctaactca acggaaactg ctccaaaatc     3540

tgatacaaca acacaagctg atacttcaaa ttcagaaagt gttccatcag agacaactga     3600

aacagtggct gaaaatagtc cgcaagaaag tgcatcagta gagaaaaatg cagaagaagc     3660

aaccgagaca acacctcaaa atgatgaagt tgcaaaagaa gctaaaccaa ctgtagagac     3720

taaggatcaa acaaatgaaa tgactcaaag tggaagtgaa aataccacag aaactcaagc     3780

agaaaataaa gtttctcaac caacagaaac agataaaata gctacggtag aaacagagga     3840

gacggctaga gtagaaaaag aggaaactca agtagcttct caaacgtttc caaaacaaga     3900

agaaccagaa atgactaaac agcaagctga gcctgaaaca aggaatgttc cgattgttaa     3960

taatctagaa gaagctcaac cgcaaacaaa accgataact gttgctacgg cagagacacc     4020

tacatcaaac agtaaatcag cagaaaaaac tcaaccaagt ggagaaacta acgctgaacc     4080

tgtaacgcct gtagtcgtat cagaaaatca accagaaaat acgatttctc aaccaacaga     4140

agatacggtt gttaaagtag aaacagaaga aacgcctaaa gtagaaacgg ggggaactaa     4200

agaagcccct caagtagctt ctcaaacgtc tccgaaacaa gaagagcctg aaactgttca     4260

accgcaagcg gagcctgctc aagagaattc tccgactgtt aataatgtag aagaagctca     4320

accgcaaaca caaccgacaa tagttgcagc gaaagagata actgcaccaa acagtgcgca     4380

gaaagaaact gcccaatctg tagctaatcc aaaaacagct gaacaacctg tgacagtaag     4440

cactgaaaac cctgtagtgg aaaatccaga gaataccact caacctgcgg ttaattcaga     4500

agcagttcaa ccagaaacag cgacaacagg aactgttagt cagcctaaag aggcttctac     4560

tgatgaaaca acagtggctt ctactgatga aacaacaggg acttctgctg aagaaacaac     4620

tgtagctgat aattcagaag ccagtaaacc gaagcgcaga tctagaagag atgttagctc     4680

aactccgcat aatgttgagc cagctgttac aggtggtggt agagatcgtt ctgcagtagt     4740

agtaccatta cgtgatctca caagtacaaa caccaatgcg gtactttctg acgcaatggc     4800

aaaagcacaa tttgttgcat taaatgtagg gaaagcagtt tctcaacata ttagccagtt     4860

agaaatgaat aacgagggac aatataacgt ttgggtgtcg aatacctcta tgaacgaaaa     4920

ttattcctca gatcaatatc gtcgttttag ttctaaaagt gcgcaaactc aacttggttg     4980

ggatcaaaca atctcgaaca atgttcagtt aggtggcata ttgacttatg ttcgcaatag     5040

taacagcttt gataaggcaa gcagtaaaaa caccttagca caagcaaatt tctattctaa     5100

atattatgca gataatcatt ggtatttagc ggtggattta ggctatggta atttccaaag     5160

caacttacaa actaatcata atgcgaaatt tgatcgccat actgcacaaa ttggtttaac     5220

cgcaggcaaa gcatttaatc ttggcaatgt tgctgttaaa ccaactgtgg gggttcgtta     5280

tagttactta tcaaacgctg attttgcatt agatcaagat cgcattaaag taaatcctat     5340

atctgtcaaa acagcctttg ctcaagttga tttaagttat acttataact taggcgagtt     5400

tgccattacg ccaattttgt ctgctcgata tgatgccaat caaggcaatg gcaaaattaa     5460

tgtaagtgga tatgcttttg cttacaatgt ggaaaaccaa cagcaatata acgcaggact     5520

taaattgaaa tatcataatg tgaaattaag tctaatgggt ggattaacaa aagcaaaaca     5580

agcggaaaaa caaaaaactg ctgaagtaaa actaagtttt agtttttaat aagcctgttt     5640

gaattaatgt tataaacaac aaagccctgt gtattacagg gctttatttt tgaatgaaat     5700

tcagtgatta agtgcggtg                                                  5719


<210>  19
<211>  1764
<212>  PRT
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(1764)
<223>  full-length precursor IgA1 protease from aegyptius strain

<400>  19

Met Leu Asn Lys Lys Phe Lys Leu Asn Phe Ile Ala Leu Thr Val Ala 
1               5                   10                  15      


Tyr Ala Leu Thr Pro Tyr Thr Glu Ala Ala Leu Val Arg Asp Asp Val 
            20                  25                  30          


Asp Tyr Gln Ile Phe Arg Asp Phe Ala Glu Asn Lys Gly Arg Phe Ser 
        35                  40                  45              


Val Gly Ala Thr Asn Val Glu Val Arg Asp Lys Asn Asn His Ser Leu 
    50                  55                  60                  


Gly Asn Ala Leu Pro Asn Gly Ile Pro Met Ile Asp Phe Ser Val Val 
65                  70                  75                  80  


Asp Val Asn Lys Arg Ile Gly Thr Leu Val Asp Pro Gln Tyr Ile Val 
                85                  90                  95      


Ser Val Lys His Ala His Gln Tyr Met Asn Asp Phe Tyr Phe Gly His 
            100                 105                 110         


Tyr Asn Gly His Arg Asp Val Ser Asn Asp Glu Asn Lys Tyr Ser Val 
        115                 120                 125             


Val Thr Gln Asn Asn Val Asn Ser Ser Glu Lys Trp Asp Val Asn Lys 
    130                 135                 140                 


Arg Leu Asp Asp Tyr Asn Met Pro Arg Leu Asn Lys Phe Val Thr Glu 
145                 150                 155                 160 


Val Ala Pro Thr Thr Pro Thr Leu Ala Gly Asp Asp Leu Glu Thr Tyr 
                165                 170                 175     


Lys Asp Lys Glu Lys Tyr Pro Ser Phe Val Arg Val Gly Ala Gly Arg 
            180                 185                 190         


Gln Leu Val Tyr Glu Lys Gly Ser Arg His Val Glu Gly Asn Glu His 
        195                 200                 205             


Gly Glu Asp Leu Lys Asp Leu Ser Val Ala Tyr Asn Tyr Ala Ile Gly 
    210                 215                 220                 


Gly Thr Pro Tyr Glu Gly Ile Asn Ile Asp Pro Ser Gln Ser Lys Lys 
225                 230                 235                 240 


Gly Leu Ile Gly Phe Gly Asp Ser Arg Lys Asp His Val Ile Asp Thr 
                245                 250                 255     


Lys Ile Leu Leu Ser Gln Ala Pro Leu Thr Asn Tyr Gly Val Leu Gly 
            260                 265                 270         


Asp Ser Gly Ser Pro Leu Phe Ala Phe Asp Lys Gln Gln Asn Lys Trp 
        275                 280                 285             


Ile Phe Ile Gly Pro Tyr Thr Tyr Trp Ala Gly Tyr Glu Lys Lys Ser 
    290                 295                 300                 


Trp Gln Glu Trp Asn Ile Tyr Lys Thr Thr Phe Ala Asp Gly Ile Lys 
305                 310                 315                 320 


Asn Arg Asp Asn Ala Lys Pro Val Pro Phe Ser Asn Lys Glu Tyr Arg 
                325                 330                 335     


Trp Thr Asn Thr Thr Asn His Gln Ser Glu Ile Lys Asn Thr Asp His 
            340                 345                 350         


Thr Ile Thr Val Thr Leu Pro Ser Asp Pro Asp Arg Leu Val Asn Tyr 
        355                 360                 365             


Gln Lys Glu Glu Asn Lys Asn Thr Gly Gln Asn Val Ile Phe Glu Gly 
    370                 375                 380                 


Asn Gly Asn Ser Lys Asn Thr Leu Val Leu Glu Asn Asn Ile Asn Gln 
385                 390                 395                 400 


Gly Ala Gly Gly Leu Phe Phe Lys Gly Asn Tyr Glu Val Lys Gly Thr 
                405                 410                 415     


Thr Asp Asn Ile Thr Trp Val Gly Gly Gly Ile Asp Val Ala Glu Gly 
            420                 425                 430         


Lys Thr Val Thr Trp Lys Val His Asn Pro Glu Lys Asp His Leu Ala 
        435                 440                 445             


Lys Ile Gly Lys Gly Lys Leu Ile Val Glu Gly Lys Gly Asp Asn Lys 
    450                 455                 460                 


Gly Ser Leu Lys Val Gly Asp Gly Thr Val Val Leu Lys Gln Gln Thr 
465                 470                 475                 480 


Thr Thr Gly Gln His Ala Phe Ala Ser Val Gly Ile Val Ser Gly Arg 
                485                 490                 495     


Ser Thr Val Val Leu Asn Asp Asp Lys Gln Val Asp Pro Asn Ser Ile 
            500                 505                 510         


Tyr Phe Gly Phe Arg Gly Gly Arg Leu Asp Leu Asn Gly Asn Ser Leu 
        515                 520                 525             


Thr Phe Asp His Ile Arg Asn Ile Asp Asp Gly Ala Arg Leu Val Asn 
    530                 535                 540                 


His Asn Met Thr Asn Ala Ser Asn Ile Thr Ile Thr Gly Glu Ser Leu 
545                 550                 555                 560 


Ile Thr Asp Pro Lys Lys Ile Asn Pro Tyr Tyr Ile Lys Ala Arg Glu 
                565                 570                 575     


Glu Asp Asn Pro Tyr Ala Phe Arg Trp Ile Lys Asp Gly Glu Gln Leu 
            580                 585                 590         


Tyr Phe Asn Leu Glu Asn Tyr Thr Tyr Tyr Ala Leu Arg Lys Gly Gly 
        595                 600                 605             


Lys Ala Asn Ser Gln Leu Pro Tyr Asn Asp Lys Glu Ser Asn Glu Asn 
    610                 615                 620                 


Trp Leu Tyr Met Gly Lys Asn Ala Asp Glu Ala Lys Arg Asn Val Met 
625                 630                 635                 640 


Lys His Ile Asn Asn Glu Arg Met Asn Gly Phe Asn Gly Tyr Phe Gly 
                645                 650                 655     


Glu Glu Glu Gly Lys Asp Asn Gly Asn Leu Asn Val Thr Phe Lys Gly 
            660                 665                 670         


Lys Thr Glu Gln Asn Arg Phe Leu Leu Thr Gly Gly Thr Asn Leu Asn 
        675                 680                 685             


Gly Asn Leu Lys Val Glu Gln Gly Thr Leu Phe Leu Ser Gly Arg Pro 
    690                 695                 700                 


Thr Pro His Ala Arg Asp Ile Ala Gly Ile Ser Ser Thr Lys Lys Asp 
705                 710                 715                 720 


Ser His Phe Ala Glu Asn Asn Glu Val Val Val Glu Asp Asp Trp Ile 
                725                 730                 735     


Asn Arg Asn Phe Lys Ala Thr Thr Met Asn Val Thr Gly Asn Ala Ser 
            740                 745                 750         


Leu Tyr Ser Gly Arg Asn Val Glu Ser Ile Thr Ser Asn Ile Thr Ala 
        755                 760                 765             


Ser Ser Lys Ala Gln Val His Ile Gly Tyr Lys Lys Gly Asp Thr Val 
    770                 775                 780                 


Cys Val Arg Ser Asp Tyr Thr Gly Tyr Val Thr Cys His Asn Gly Asp 
785                 790                 795                 800 


Leu Ser Glu Lys Ala Leu Asn Ser Phe Asn Ala Thr Asn Val Phe Gly 
                805                 810                 815     


Asn Val Asn Leu Ser Gly Asn Ala Asn Phe Thr Leu Gly Lys Ala Asn 
            820                 825                 830         


Leu His Gly Ser Ile Gln Ala Gly Gly Asn Ser Gln Val His Leu Thr 
        835                 840                 845             


Glu Asn Ser His Trp Tyr Leu Thr Gly Asp Ser Asn Val His Gln Leu 
    850                 855                 860                 


Asp Leu Lys Asn Gly His Ile His Leu Asn Ser Ala Asp Asn Lys Asn 
865                 870                 875                 880 


Asn Val Thr Lys Tyr Asn Thr Leu Asn Ile Ser Asn Leu Ser Gly Asn 
                885                 890                 895     


Gly Ser Phe Tyr Tyr Leu Thr Asp Leu Ser Lys Asn Gln Gly Asp Lys 
            900                 905                 910         


Val Val Val Thr Lys Ser Ala Lys Gly Asn Phe Thr Leu Gln Val Ala 
        915                 920                 925             


Asp Lys Thr Gly Glu Pro Thr Lys Asn Glu Leu Thr Leu Phe Asp Ala 
    930                 935                 940                 


Ser Asn Ala Thr Arg Ser Asn Leu Val Val Thr Leu Ala Asn Gly Ser 
945                 950                 955                 960 


Val Asp Arg Gly Ala Trp Lys Tyr Lys Leu Arg Glu Asn Asn Gly Arg 
                965                 970                 975     


Tyr Asp Leu Tyr Asn Pro Glu Val Glu Arg Arg His Gln Thr Val Asp 
            980                 985                 990         


Thr Pro Ser Val Glu Met Pro Asn  Asp Met Gln Ala Asp  Ala Pro Ser 
        995                 1000                 1005             


Ala Pro  Ser Asn Asn Glu Glu  Ile Ala Arg Val Asp  Ala Pro Val 
    1010                 1015                 1020             


Pro Pro  Pro Ala Pro Pro Ala  Pro Ala Thr Gly Ser  Ala Met Ala 
    1025                 1030                 1035             


Lys Glu  Gln Pro Lys Thr Arg  Pro Ala Glu Thr Ala  Gln Pro Thr 
    1040                 1045                 1050             


Met Glu  Glu Thr Lys Ala Ala  Asn Ser Thr Glu Thr  Ala Pro Lys 
    1055                 1060                 1065             


Ser Asp  Thr Thr Thr Gln Ala  Asp Thr Ser Asn Ser  Glu Ser Val 
    1070                 1075                 1080             


Pro Ser  Glu Thr Thr Glu Thr  Val Ala Glu Asn Ser  Pro Gln Glu 
    1085                 1090                 1095             


Ser Ala  Ser Val Glu Lys Asn  Ala Glu Glu Ala Thr  Glu Thr Thr 
    1100                 1105                 1110             


Pro Gln  Asn Asp Glu Val Ala  Lys Glu Ala Lys Pro  Thr Val Glu 
    1115                 1120                 1125             


Thr Lys  Asp Gln Thr Asn Glu  Met Thr Gln Ser Gly  Ser Glu Asn 
    1130                 1135                 1140             


Thr Thr  Glu Thr Gln Ala Glu  Asn Lys Val Ser Gln  Pro Thr Glu 
    1145                 1150                 1155             


Thr Asp  Lys Ile Ala Thr Val  Glu Thr Glu Glu Thr  Ala Arg Val 
    1160                 1165                 1170             


Glu Lys  Glu Glu Thr Gln Val  Ala Ser Gln Thr Phe  Pro Lys Gln 
    1175                 1180                 1185             


Glu Glu  Pro Glu Met Thr Lys  Gln Gln Ala Glu Pro  Glu Thr Arg 
    1190                 1195                 1200             


Asn Val  Pro Ile Val Asn Asn  Leu Glu Glu Ala Gln  Pro Gln Thr 
    1205                 1210                 1215             


Lys Pro  Ile Thr Val Ala Thr  Ala Glu Thr Pro Thr  Ser Asn Ser 
    1220                 1225                 1230             


Lys Ser  Ala Glu Lys Thr Gln  Pro Ser Gly Glu Thr  Asn Ala Glu 
    1235                 1240                 1245             


Pro Val  Thr Pro Val Val Val  Ser Glu Asn Gln Pro  Glu Asn Thr 
    1250                 1255                 1260             


Ile Ser  Gln Pro Thr Glu Asp  Thr Val Val Lys Val  Glu Thr Glu 
    1265                 1270                 1275             


Glu Thr  Pro Lys Val Glu Thr  Gly Gly Thr Lys Glu  Ala Pro Gln 
    1280                 1285                 1290             


Val Ala  Ser Gln Thr Ser Pro  Lys Gln Glu Glu Pro  Glu Thr Val 
    1295                 1300                 1305             


Gln Pro  Gln Ala Glu Pro Ala  Gln Glu Asn Ser Pro  Thr Val Asn 
    1310                 1315                 1320             


Asn Val  Glu Glu Ala Gln Pro  Gln Thr Gln Pro Thr  Ile Val Ala 
    1325                 1330                 1335             


Ala Lys  Glu Ile Thr Ala Pro  Asn Ser Ala Gln Lys  Glu Thr Ala 
    1340                 1345                 1350             


Gln Ser  Val Ala Asn Pro Lys  Thr Ala Glu Gln Pro  Val Thr Val 
    1355                 1360                 1365             


Ser Thr  Glu Asn Pro Val Val  Glu Asn Pro Glu Asn  Thr Thr Gln 
    1370                 1375                 1380             


Pro Ala  Val Asn Ser Glu Ala  Val Gln Pro Glu Thr  Ala Thr Thr 
    1385                 1390                 1395             


Gly Thr  Val Ser Gln Pro Lys  Glu Ala Ser Thr Asp  Glu Thr Thr 
    1400                 1405                 1410             


Val Ala  Ser Thr Asp Glu Thr  Thr Gly Thr Ser Ala  Glu Glu Thr 
    1415                 1420                 1425             


Thr Val  Ala Asp Asn Ser Glu  Ala Ser Lys Pro Lys  Arg Arg Ser 
    1430                 1435                 1440             


Arg Arg  Asp Val Ser Ser Thr  Pro His Asn Val Glu  Pro Ala Val 
    1445                 1450                 1455             


Thr Gly  Gly Gly Arg Asp Arg  Ser Ala Val Val Val  Pro Leu Arg 
    1460                 1465                 1470             


Asp Leu  Thr Ser Thr Asn Thr  Asn Ala Val Leu Ser  Asp Ala Met 
    1475                 1480                 1485             


Ala Lys  Ala Gln Phe Val Ala  Leu Asn Val Gly Lys  Ala Val Ser 
    1490                 1495                 1500             


Gln His  Ile Ser Gln Leu Glu  Met Asn Asn Glu Gly  Gln Tyr Asn 
    1505                 1510                 1515             


Val Trp  Val Ser Asn Thr Ser  Met Asn Glu Asn Tyr  Ser Ser Asp 
    1520                 1525                 1530             


Gln Tyr  Arg Arg Phe Ser Ser  Lys Ser Ala Gln Thr  Gln Leu Gly 
    1535                 1540                 1545             


Trp Asp  Gln Thr Ile Ser Asn  Asn Val Gln Leu Gly  Gly Ile Leu 
    1550                 1555                 1560             


Thr Tyr  Val Arg Asn Ser Asn  Ser Phe Asp Lys Ala  Ser Ser Lys 
    1565                 1570                 1575             


Asn Thr  Leu Ala Gln Ala Asn  Phe Tyr Ser Lys Tyr  Tyr Ala Asp 
    1580                 1585                 1590             


Asn His  Trp Tyr Leu Ala Val  Asp Leu Gly Tyr Gly  Asn Phe Gln 
    1595                 1600                 1605             


Ser Asn  Leu Gln Thr Asn His  Asn Ala Lys Phe Asp  Arg His Thr 
    1610                 1615                 1620             


Ala Gln  Ile Gly Leu Thr Ala  Gly Lys Ala Phe Asn  Leu Gly Asn 
    1625                 1630                 1635             


Val Ala  Val Lys Pro Thr Val  Gly Val Arg Tyr Ser  Tyr Leu Ser 
    1640                 1645                 1650             


Asn Ala  Asp Phe Ala Leu Asp  Gln Asp Arg Ile Lys  Val Asn Pro 
    1655                 1660                 1665             


Ile Ser  Val Lys Thr Ala Phe  Ala Gln Val Asp Leu  Ser Tyr Thr 
    1670                 1675                 1680             


Tyr Asn  Leu Gly Glu Phe Ala  Ile Thr Pro Ile Leu  Ser Ala Arg 
    1685                 1690                 1695             


Tyr Asp  Ala Asn Gln Gly Asn  Gly Lys Ile Asn Val  Ser Gly Tyr 
    1700                 1705                 1710             


Ala Phe  Ala Tyr Asn Val Glu  Asn Gln Gln Gln Tyr  Asn Ala Gly 
    1715                 1720                 1725             


Leu Lys  Leu Lys Tyr His Asn  Val Lys Leu Ser Leu  Met Gly Gly 
    1730                 1735                 1740             


Leu Thr  Lys Ala Lys Gln Ala  Glu Lys Gln Lys Thr  Ala Glu Val 
    1745                 1750                 1755             


Lys Leu  Ser Phe Ser Phe 
    1760                 


<210>  20
<211>  613
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(613)
<223>  partial nucleotide sequence for IgA1 protease from 8625 strain

<400>  20
ggaagaacag gtataagcaa ttcaataatt attgatggac catctccgta tgtgacaatt       60

atacataaag acccaaatgg aactgttcta gatgatacac tagcattaag agaaaaattc      120

gaagaatcag tcgataaata caaacttcat tttactggat taatcgctga caaaattgca      180

aaagaaaaac tgaatactta cgtcctcact tataaaaaag cagacgaagc tatgcctgca      240

gacgaagcta tgccaactga tgtacctagt acttctgtta ctggatcaac aatggcaaac      300

gagcaaccag aaactcgtcc tgcaaaaatc gctcaacccg cgatggaaga gacagatact      360

gctcacatat cgggatctga accacaggct gatacaacac aagctgatac ttcaaattca      420

gaaagtgttc catcagagac aactaaaaca gtggctgaaa ataatccgca agaaagtgca      480

acagcagaga aaaacgagca agaagtcgcc gagacaacac ctcaaaatgg agaagttgca      540

aaagaagctc aaccaactgt agaagctagc actcaaacaa atgaagtcgc ccaaaatgga      600

agcgaaaaag agg                                                         613


<210>  21
<211>  1413
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(1413)
<223>  partial nucleotide sequence for IgA1 protease from HK284 strain

<400>  21
gcaacaaatg tggaagtgag agataaaaat aaccaatctt taggcagtgc cttacctaac       60

ggtattccga tgattgattt tagtgtggtg gatgtaaata aacgtattgg tacattagtg      120

gatccgcaat atattgtaag cgtaaaacac gcacacaaac atataaatga cttttatttt      180

gggcattata acggacaccg tgatgtttct gatgatgaaa ataaatatag tgtggtcaca      240

caaaataatg ttaaaccaaa tgaagactgg cacgtagata agcgattaga tgactataac      300

atgcctcgtt taaataaatt tgtgaccgag gttgcaccaa ctacgcctac attagcagga      360

gacgatttag aaacctataa agataaagaa aaatatccgt cctttgtacg agtaggtgct      420

ggtactcagt ttgtttatga aaaaggttct tactatgttg aaaaaactac ccgtaataat      480

gatattaaat tcttagatga ggcatatcgc tatgctatcg gtggtacacc ttatgaaggg      540

attaatattg atccttccca aagtaaaaaa ggacttatag gttttggaga tagccgtgaa      600

aatcacgtta ttgatgctaa aactttgctt tctcaagacc cacttaccaa ctacggcgta      660

ttaggcgata gtggctcgcc tttatttgct tttgataaac aacaaaacaa atgggttttt      720

atcgggcctt atacttattg ggctggctat ggtaaaaaat cttggcaaga atggaatatt      780

tataaaaaag attttgctga taatataaaa aaacgagata acgctgaagc tgtgcctttc      840

tctacttcag aatatcattg gacaaacact acaaatcatc aaagtgaaat aaaaaacact      900

gatcatacaa ttactgtaac actcccctca gatccaaata gacttgttaa tttccaacaa      960

aaagaacatt tacaaacagg acaaaatgta acatttgacg atagcactaa taatgggaaa     1020

ggcacactta ttttagatga tcatatcaat caaggtgctg gcggtttatt ctttaaagga     1080

aactatgaag ttaaaggaaa aacggacgat attacttggg taggcggcgg aattgatgtt     1140

gcagaaggaa aagaagttgt ttggaaagta cataatcctg aaaaagatca tttagccaag     1200

attggtaaag gaacattaat tgttgagggc aaagggaata ataaaggttc gctaaaagtg     1260

ggcgatggta ctgtcgtttt aaaacaacaa acgaatggtt cgggagaaca cgcttttgct     1320

tctgtaggga ttgtaagtgg tcgctcaacc gttgtgctta atgatgataa acaagtagat     1380

ccaaattcaa tttactttgg ctttagaggc ggt                                  1413


<210>  22
<211>  1477
<212>  DNA
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(1477)
<223>  partial nucleotide sequence for IgA1 protease from Da66 strain

<400>  22
gcaacaaatg tggaagtgag agataaaaaa aataataatt tgggcagcgt gctacctaaa       60

gatattccta tgattgactt tagtgttgtg gatgtagata aacgcattgc cacattgata      120

aatccacaat atgttgtggg ggtaaaacac gttggtaacg gtgtgggtga actacatttt      180

gggaatttaa atgggaattg gaaccctaaa tttggaaatt ctattcagca tcgagatgta      240

tcttgggagg aaaacagata ttacactgtt gaaaaaaata atttttcttc tgaattaaac      300

ggaaaaacac aaaataacga aaaagataaa cagtatacat ctaataaaaa agatgttcct      360

tccgaattat atggacaagc cttagttaaa gaacagcaaa accaaaaacg ccgtgaagat      420

tattatatgc cacgccttga taaatttgtt accgaagttg caccgataga ggcttcaact      480

acaagtagtg atgctggaac atataatgat cagaataaat atcctgcttt tgtgagatta      540

ggaagtggct ctcaatttat ctataaaaaa ggaagccatt atgaattaat tttagaagag      600

aaaaacgaga aaaaggaaat aatacacaga tgggatgtag gtggagataa tcttaaatta      660

gttggtaacg cttataccta tggtattgca ggcacgcctt ataaagtgaa tcatacagac      720

gatggactca ttgggtttgg tgattcaacc gaagatcata acgatccaaa agagatatta      780

tctcgtaaac cgcttactaa ttatgctgtc ttgggagata gtggctcacc gttatttgtt      840

tatgataaat ctaaagagaa atggcttttc cttggtgctt atgatttttg gggagggtat      900

aagaaaaaat cttggcaaga atggaatatt tataaaccac aatttgctga aaatattctc      960

aaaaaagaca gtgctggttt actgaaaggt aatacgcaat ataactggac aagcaaaggt     1020

aatacaagct tgatatctgg aacatctgaa tcattaagtg ttgatttagt ggataataaa     1080

aatctcaatc atgggaaaaa tgttacgttt gaaggaagtg gaaaccttac cttaaataat     1140

aatatcgatc aaggtgcagg cggattgttc tttgaaggtg attatgaagt taaaggcact     1200

tcagaaaata cgacttggaa aggggctggt atatctgttg ctgaaggaaa aacagtaaag     1260

tggaaagtgc ataaccctca atttgatcgt ttagctaaaa ttggtaaagg aaagctaatt     1320

gttgaaggaa gaggagataa taaaggttcg ctaaaagtgg gcgatggcac agttgtttta     1380

aaacaacaaa caactacagg acaacacgct tttgcttctg taggaattgt aagtggtcgc     1440

tcaactgttg tacttaatga tgataaccaa gtagatc                              1477


<210>  23
<211>  1739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for H. influenzae IgA1 proteases (generated by
       Clustal W alignment program)

<400>  23

Met Leu Asn Lys Lys Phe Lys Leu Asn Phe Ile Ala Leu Thr Val Ala 
1               5                   10                  15      


Tyr Ala Leu Thr Pro Tyr Thr Glu Ala Ala Leu Val Arg Asp Asp Val 
            20                  25                  30          


Asp Tyr Gln Ile Phe Arg Asp Phe Ala Glu Asn Lys Gly Lys Phe Ser 
        35                  40                  45              


Val Gly Ala Thr Asn Val Glu Val Arg Asp Lys Asn Asn His Ser Leu 
    50                  55                  60                  


Gly Asn Ala Leu Pro Asn Gly Ile Pro Met Ile Asp Phe Ser Val Val 
65                  70                  75                  80  


Asp Val Asp Lys Arg Ile Ala Thr Leu Ile Asn Pro Gln Tyr Val Val 
                85                  90                  95      


Gly Val Lys His Val Ser Asn Gly Val Ser Glu Leu His Phe Gly Asn 
            100                 105                 110         


Leu Asn Gly Asn Met Asn Asn Gly Asn Ala Lys Ser His Arg Asp Val 
        115                 120                 125             


Ser Ser Glu Glu Asn Arg Tyr Phe Ser Val Glu Lys Asn Glu Tyr Pro 
    130                 135                 140                 


Thr Lys Leu Asn Gly Lys Ala Val Thr Thr Glu Asp Gln Asp Thr Gln 
145                 150                 155                 160 


Lys Arg Arg Glu Asp Tyr Tyr Met Pro Arg Leu Asp Lys Phe Val Thr 
                165                 170                 175     


Glu Val Ala Pro Ile Glu Ala Ser Thr Ala Ser Ser Asp Ala Gly Thr 
            180                 185                 190         


Tyr Asn Asp Gln Asn Lys Tyr Pro Ala Phe Val Arg Leu Gly Ser Gly 
        195                 200                 205             


Ser Gln Phe Ile Tyr Lys Lys Gly Asp Asn Tyr Ser Leu Ile Leu Asn 
    210                 215                 220                 


Asn His Glu Val Gly Gly Asn Asn Leu Lys Leu Val Gly Asp Ala Tyr 
225                 230                 235                 240 


Thr Tyr Gly Ile Ala Gly Thr Pro Tyr Lys Val Asn His Glu Asn Asn 
                245                 250                 255     


Gly Leu Ile Gly Phe Gly Asn Ser Lys Glu Glu His Ser Asp Pro Lys 
            260                 265                 270         


Gly Ile Leu Ser Gln Asp Pro Leu Thr Asn Tyr Ala Val Leu Gly Asp 
        275                 280                 285             


Ser Gly Ser Pro Leu Phe Val Tyr Asp Arg Glu Lys Gly Lys Trp Leu 
    290                 295                 300                 


Phe Leu Gly Ser Tyr Asp Phe Trp Ala Gly Tyr Asn Lys Lys Ser Trp 
305                 310                 315                 320 


Gln Glu Trp Asn Ile Tyr Lys Pro Glu Phe Ala Lys Thr Val Leu Asp 
                325                 330                 335     


Lys Asp Ser Ala Gly Ser Leu Thr Gly Ser Asn Thr Gln Tyr Asn Trp 
            340                 345                 350         


Asn Pro Thr Gly Lys Thr Ser Thr Ile Thr Gly Gly Glu Glu Ser Leu 
        355                 360                 365             


Asn Val Asp Leu Ala Asp Gly Lys Asp Asp Thr Asp Ser Lys Lys Pro 
    370                 375                 380                 


Asn His Gly Lys Ser Val Thr Phe Glu Gly Ser Gly Thr Leu Thr Leu 
385                 390                 395                 400 


Asn Asn Asn Ile Asp Gln Gly Ala Gly Gly Leu Phe Phe Glu Gly Asp 
                405                 410                 415     


Tyr Glu Val Lys Gly Thr Ser Asp Asn Thr Thr Trp Lys Gly Ala Gly 
            420                 425                 430         


Val Ser Val Ala Asp Gly Lys Thr Val Thr Trp Lys Val His Asn Pro 
        435                 440                 445             


Lys Tyr Asp Arg Leu Ala Lys Ile Gly Lys Gly Thr Leu Ile Val Glu 
    450                 455                 460                 


Gly Lys Gly Asp Asn Lys Gly Ser Leu Lys Val Gly Asp Gly Thr Val 
465                 470                 475                 480 


Ile Leu Lys Gln Gln Ala Asp Ala Asn Asn Lys Gln His Ala Phe Ala 
                485                 490                 495     


Gln Val Gly Ile Val Ser Gly Arg Ser Thr Leu Val Leu Asn Asp Asp 
            500                 505                 510         


Lys Gln Val Asp Pro Asn Ser Ile Tyr Phe Gly Phe Arg Gly Gly Arg 
        515                 520                 525             


Leu Asp Leu Asn Gly Asn Ser Leu Thr Phe Asp His Ile Arg Asn Ile 
    530                 535                 540                 


Asp Asp Gly Ala Arg Leu Val Asn His Asn Met Ser Lys Thr Ser Asn 
545                 550                 555                 560 


Ile Thr Ile Thr Gly Glu Ser Leu Ile Thr Asp Pro Asn Thr Ile Thr 
                565                 570                 575     


Pro Tyr Asn Ile Asp Ala Pro Asp Glu Asp Asn Pro Tyr Ala Phe Arg 
            580                 585                 590         


Arg Ile Lys Asp Gly Gly Gln Leu Tyr Leu Asn Leu Glu Asn Tyr Thr 
        595                 600                 605             


Tyr Tyr Ala Leu Arg Lys Gly Ala Ser Thr Arg Ser Glu Leu Pro Lys 
    610                 615                 620                 


Asn Ser Gly Glu Ser Asn Glu Asn Trp Leu Tyr Met Gly Lys Thr Ser 
625                 630                 635                 640 


Asp Glu Ala Lys Arg Asn Val Met Asn His Ile Asn Asn Glu Arg Met 
                645                 650                 655     


Asn Gly Phe Asn Gly Tyr Phe Gly Glu Glu Glu Gly Lys Asn Asn Gly 
            660                 665                 670         


Asn Leu Asn Val Thr Phe Lys Gly Lys Ser Glu Gln Asn Arg Phe Leu 
        675                 680                 685             


Leu Thr Gly Gly Thr Asn Leu Asn Gly Asp Leu Lys Val Glu Lys Gly 
    690                 695                 700                 


Thr Leu Phe Leu Ser Gly Arg Pro Thr Pro His Ala Arg Asp Ile Ala 
705                 710                 715                 720 


Gly Ile Ser Ser Thr Lys Lys Asp Pro His Phe Ala Glu Asn Asn Glu 
                725                 730                 735     


Val Val Val Glu Asp Asp Trp Ile Asn Arg Asn Phe Lys Ala Thr Asn 
            740                 745                 750         


Ile Asn Val Thr Gly Asn Ala Ser Leu Tyr Ser Gly Arg Asn Val Ala 
        755                 760                 765             


Asn Ile Thr Ser Asn Ile Thr Ala Ser Asn Asn Ala Lys Val His Ile 
    770                 775                 780                 


Gly Tyr Lys Ala Gly Asp Thr Val Cys Val Arg Ser Asp Tyr Thr Gly 
785                 790                 795                 800 


Tyr Val Thr Cys Thr Thr Asp Lys Leu Ser Asp Lys Ala Leu Asn Ser 
                805                 810                 815     


Phe Asn Ala Thr Asn Leu Arg Gly Asn Val Asn Leu Ser Glu Asn Ala 
            820                 825                 830         


Asn Phe Val Leu Gly Lys Ala Asn Leu Phe Gly Thr Ile Gln Ser Arg 
        835                 840                 845             


Gly Asn Ser Gln Val Arg Leu Thr Glu Asn Ser His Trp His Leu Thr 
    850                 855                 860                 


Gly Asp Ser Asn Val His Gln Leu Asp Leu Ala Asn Gly His Ile His 
865                 870                 875                 880 


Leu Asn Ala Ala Asp Asp Ala Asn Lys Val Thr Lys Tyr Asn Thr Leu 
                885                 890                 895     


Thr Val Asn Ser Leu Ser Gly Asn Gly Ser Phe Tyr Tyr Leu Thr Asp 
            900                 905                 910         


Leu Ser Asn Lys Gln Gly Asp Lys Val Val Val Thr Lys Ser Ala Thr 
        915                 920                 925             


Gly Asn Phe Thr Leu Gln Val Ala Asp Lys Thr Gly Glu Pro Asn His 
    930                 935                 940                 


Asn Glu Leu Thr Leu Phe Asp Ala Ser Asn Ala Thr Arg Asn Asn Leu 
945                 950                 955                 960 


Asn Val Ser Leu Val Gly Asn Thr Val Asp Leu Gly Ala Trp Lys Tyr 
                965                 970                 975     


Lys Leu Arg Asn Val Asn Gly Arg Tyr Asp Leu Tyr Asn Pro Glu Val 
            980                 985                 990         


Glu Lys Arg Asn Gln Thr Val Asp  Thr Thr Asn Ile Thr  Thr Pro Asn 
        995                 1000                 1005             


Asn Ile  Gln Ala Asp Val Pro  Ser Val Pro Ser Asn  Asn Glu Glu 
    1010                 1015                 1020             


Ile Ala  Arg Val Asp Glu Ala  Pro Val Pro Pro Pro  Ala Pro Ala 
    1025                 1030                 1035             


Thr Ser  Ala Ala Glu Gln Pro  Thr Arg Pro Ala Glu  Thr Ala Gln 
    1040                 1045                 1050             


Pro Met  Glu Glu Thr Ala Asn  Ser Thr Glu Thr Ala  Pro Lys Ser 
    1055                 1060                 1065             


Asp Thr  Thr Gln Asn Ser Glu  Ser Val Pro Ser Glu  Thr Thr Glu 
    1070                 1075                 1080             


Thr Val  Ala Glu Asn Ser Lys  Gln Glu Ser Lys Thr  Val Glu Lys 
    1085                 1090                 1095             


Asn Glu  Gln Asp Ala Thr Glu  Thr Thr Ala Gln Asn  Gly Glu Val 
    1100                 1105                 1110             


Ala Lys  Glu Ala Lys Pro Asn  Val Lys Ala Asn Thr  Gln Thr Asn 
    1115                 1120                 1125             


Glu Val  Ala Gln Ser Gly Ser  Glu Thr Glu Glu Thr  Gln Thr Thr 
    1130                 1135                 1140             


Glu Thr  Lys Thr Glu Thr Ala  Thr Val Glu Lys Glu  Glu Lys Ala 
    1145                 1150                 1155             


Lys Val  Glu Lys Glu Asp Glu  Ile Gln Glu Ala Pro  Gln Met Ala 
    1160                 1165                 1170             


Ser Glu  Thr Ser Pro Lys Gln  Ala Lys Pro Ala Pro  Lys Glu Val 
    1175                 1180                 1185             


Ser Thr  Asp Thr Lys Val Glu  Glu Thr Gln Val Gln  Ala Gln Pro 
    1190                 1195                 1200             


Gln Thr  Gln Ser Thr Thr Val  Ala Ala Ala Glu Ala  Thr Ser Pro 
    1205                 1210                 1215             


Asn Ser  Lys Pro Ala Glu Glu  Thr Gln Pro Ser Glu  Lys Thr Asn 
    1220                 1225                 1230             


Ala Glu  Pro Val Thr Pro Val  Val Ser Lys Asn Gln  Thr Glu Asn 
    1235                 1240                 1245             


Thr Thr  Asp Gln Pro Thr Glu  Arg Glu Lys Thr Ala  Lys Val Glu 
    1250                 1255                 1260             


Thr Glu  Lys Thr Gln Glu Val  Pro Gln Val Ala Ser  Gln Ala Ser 
    1265                 1270                 1275             


Pro Lys  Gln Glu Gln Ser Glu  Thr Val Gln Pro Gln  Ala Glu Pro 
    1280                 1285                 1290             


Ala Arg  Glu Asn Val Pro Thr  Val Asn Asn Ala Glu  Glu Val Ile 
    1295                 1300                 1305             


Ala Glu  Pro Gln Ser Gln Thr  Ser Ala Thr Ala Ser  Thr Glu Gln 
    1310                 1315                 1320             


Pro Ala  Lys Glu Thr Ser Ile  Asn Thr Gly Ser Ala  Thr Ala Ile 
    1325                 1330                 1335             


Thr Glu  Thr Ala Glu Lys Ser  Asp Lys Pro Gln Thr  Glu Thr Ala 
    1340                 1345                 1350             


Ala Val  Thr Glu Asp Ala Ser  Gln His Lys Ala Asn  Thr Val Ala 
    1355                 1360                 1365             


Asp Asn  Ser Val Ala Asn Asn  Ser Glu Ser Ser Asp  Pro Lys Ser 
    1370                 1375                 1380             


Arg Arg  Arg Arg Ser Ile Ser  Gln Pro Gln Glu Thr  Ser Ala Glu 
    1385                 1390                 1395             


Glu Thr  Thr Ala Ala Ser Thr  Gln Glu Thr Thr Ile  Ala Asp Asn 
    1400                 1405                 1410             


Ser Lys  Lys Pro Lys Asn Arg  His Arg Arg Ser Arg  Arg Ser Val 
    1415                 1420                 1425             


Pro His  Asn Val Glu Pro Ala  Thr Thr Asn Gly Asn  Asp Arg Ser 
    1430                 1435                 1440             


Thr Val  Ala Leu Arg Asp Leu  Thr Ser Thr Asn Thr  Asn Ala Val 
    1445                 1450                 1455             


Leu Ser  Asp Ala Met Ala Lys  Ala Gln Phe Val Ala  Leu Asn Val 
    1460                 1465                 1470             


Gly Lys  Ala Val Ser Gln His  Ile Ser Gln Leu Glu  Met Asn Asn 
    1475                 1480                 1485             


Glu Gly  Gln Tyr Asn Val Trp  Val Ser Asn Thr Ser  Met Asn Glu 
    1490                 1495                 1500             


Asn Tyr  Ser Ser Ser Gln Tyr  Arg Arg Phe Ser Ser  Lys Ser Thr 
    1505                 1510                 1515             


Gln Thr  Gln Leu Gly Trp Asp  Gln Thr Ile Ser Asn  Asn Val Gln 
    1520                 1525                 1530             


Leu Gly  Gly Val Phe Thr Tyr  Val Arg Asn Ser Asn  Asn Phe Asp 
    1535                 1540                 1545             


Lys Ala  Ser Ser Lys Asn Thr  Leu Ala Gln Val Asn  Phe Tyr Ser 
    1550                 1555                 1560             


Lys Tyr  Tyr Ala Asp Asn His  Trp Tyr Leu Gly Ile  Asp Leu Gly 
    1565                 1570                 1575             


Tyr Gly  Lys Phe Gln Ser Asn  Leu Gln Thr Asn His  Asn Ala Lys 
    1580                 1585                 1590             


Phe Ala  Arg His Thr Ala Gln  Phe Gly Leu Thr Ala  Gly Lys Ala 
    1595                 1600                 1605             


Phe Asn  Leu Gly Asn Phe Gly  Ile Thr Pro Ile Val  Gly Val Arg 
    1610                 1615                 1620             


Tyr Ser  Tyr Leu Ser Asn Ala  Asp Phe Ala Leu Ala  Gln Asp Arg 
    1625                 1630                 1635             


Ile Lys  Val Asn Pro Ile Ser  Val Lys Thr Ala Phe  Ala Gln Val 
    1640                 1645                 1650             


Asp Leu  Ser Tyr Thr Tyr His  Leu Gly Glu Phe Ser  Val Thr Pro 
    1655                 1660                 1665             


Ile Leu  Ser Ala Arg Tyr Asp  Ala Asn Gln Gly Ser  Gly Lys Ile 
    1670                 1675                 1680             


Asn Val  Asn Gly Tyr Asp Phe  Ala Tyr Asn Val Glu  Asn Gln Gln 
    1685                 1690                 1695             


Gln Tyr  Asn Ala Gly Leu Lys  Leu Lys Tyr His Asn  Val Lys Leu 
    1700                 1705                 1710             


Ser Leu  Ile Gly Gly Leu Thr  Lys Ala Lys Gln Ala  Glu Lys Gln 
    1715                 1720                 1725             


Lys Thr  Ala Glu Leu Lys Leu  Ser Phe Ser Phe 
    1730                 1735                 


<210>  24
<211>  1014
<212>  PRT
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (26)..(1014)
<223>  mature, soluble form of IgA1 protease from Rd strain

<400>  24

Met Leu Asn Lys Lys Phe Lys Leu Asn Phe Ile Ala Leu Thr Val Ala 
1               5                   10                  15      


Tyr Ala Leu Thr Pro Tyr Thr Glu Ala Ala Leu Val Arg Asp Asp Val 
            20                  25                  30          


Asp Tyr Gln Ile Phe Arg Asp Phe Ala Glu Asn Lys Gly Arg Phe Ser 
        35                  40                  45              


Val Gly Ala Thr Asn Val Glu Val Arg Asp Lys Asn Asn His Ser Leu 
    50                  55                  60                  


Gly Asn Val Leu Pro Asn Gly Ile Pro Met Ile Asp Phe Ser Val Val 
65                  70                  75                  80  


Asp Val Asp Lys Arg Ile Ala Thr Leu Ile Asn Pro Gln Tyr Val Val 
                85                  90                  95      


Gly Val Lys His Val Ser Asn Gly Val Ser Glu Leu His Phe Gly Asn 
            100                 105                 110         


Leu Asn Gly Asn Met Asn Asn Gly Asn Ala Lys Ser His Arg Asp Val 
        115                 120                 125             


Ser Ser Glu Glu Asn Arg Tyr Phe Ser Val Glu Lys Asn Glu Tyr Pro 
    130                 135                 140                 


Thr Lys Leu Asn Gly Lys Ala Val Thr Thr Glu Asp Gln Thr Gln Lys 
145                 150                 155                 160 


Arg Arg Glu Asp Tyr Tyr Met Pro Arg Leu Asp Lys Phe Val Thr Glu 
                165                 170                 175     


Val Ala Pro Ile Glu Ala Ser Thr Ala Ser Ser Asp Ala Gly Thr Tyr 
            180                 185                 190         


Asn Asp Gln Asn Lys Tyr Pro Ala Phe Val Arg Leu Gly Ser Gly Ser 
        195                 200                 205             


Gln Phe Ile Tyr Lys Lys Gly Asp Asn Tyr Ser Leu Ile Leu Asn Asn 
    210                 215                 220                 


His Glu Val Gly Gly Asn Asn Leu Lys Leu Val Gly Asp Ala Tyr Thr 
225                 230                 235                 240 


Tyr Gly Ile Ala Gly Thr Pro Tyr Lys Val Asn His Glu Asn Asn Gly 
                245                 250                 255     


Leu Ile Gly Phe Gly Asn Ser Lys Glu Glu His Ser Asp Pro Lys Gly 
            260                 265                 270         


Ile Leu Ser Gln Asp Pro Leu Thr Asn Tyr Ala Val Leu Gly Asp Ser 
        275                 280                 285             


Gly Ser Pro Leu Phe Val Tyr Asp Arg Glu Lys Gly Lys Trp Leu Phe 
    290                 295                 300                 


Leu Gly Ser Tyr Asp Phe Trp Ala Gly Tyr Asn Lys Lys Ser Trp Gln 
305                 310                 315                 320 


Glu Trp Asn Ile Tyr Lys Pro Glu Phe Ala Lys Thr Val Leu Asp Lys 
                325                 330                 335     


Asp Thr Ala Gly Ser Leu Thr Gly Ser Asn Thr Gln Tyr Asn Trp Asn 
            340                 345                 350         


Pro Thr Gly Lys Thr Ser Val Ile Ser Asn Gly Ser Glu Ser Leu Asn 
        355                 360                 365             


Val Asp Leu Phe Asp Ser Ser Gln Asp Thr Asp Ser Lys Lys Asn Asn 
    370                 375                 380                 


His Gly Lys Ser Val Thr Leu Arg Gly Ser Gly Thr Leu Thr Leu Asn 
385                 390                 395                 400 


Asn Asn Ile Asp Gln Gly Ala Gly Gly Leu Phe Phe Glu Gly Asp Tyr 
                405                 410                 415     


Glu Val Lys Gly Thr Ser Asp Ser Thr Thr Trp Lys Gly Ala Gly Val 
            420                 425                 430         


Ser Val Ala Asp Gly Lys Thr Val Thr Trp Lys Val His Asn Pro Lys 
        435                 440                 445             


Ser Asp Arg Leu Ala Lys Ile Gly Lys Gly Thr Leu Ile Val Glu Gly 
    450                 455                 460                 


Lys Gly Glu Asn Lys Gly Ser Leu Lys Val Gly Asp Gly Thr Val Ile 
465                 470                 475                 480 


Leu Lys Gln Gln Ala Asp Ala Asn Asn Lys Val Lys Ala Phe Ser Gln 
                485                 490                 495     


Val Gly Ile Val Ser Gly Arg Ser Thr Val Val Leu Asn Asp Asp Lys 
            500                 505                 510         


Gln Val Asp Pro Asn Ser Ile Tyr Phe Gly Phe Arg Gly Gly Arg Leu 
        515                 520                 525             


Asp Ala Asn Gly Asn Asn Leu Thr Phe Glu His Ile Arg Asn Ile Asp 
    530                 535                 540                 


Asp Gly Ala Arg Leu Val Asn His Asn Thr Ser Lys Thr Ser Thr Val 
545                 550                 555                 560 


Thr Ile Thr Gly Glu Ser Leu Ile Thr Asp Pro Asn Thr Ile Thr Pro 
                565                 570                 575     


Tyr Asn Ile Asp Ala Pro Asp Glu Asp Asn Pro Tyr Ala Phe Arg Arg 
            580                 585                 590         


Ile Lys Asp Gly Gly Gln Leu Tyr Leu Asn Leu Glu Asn Tyr Thr Tyr 
        595                 600                 605             


Tyr Ala Leu Arg Lys Gly Ala Ser Thr Arg Ser Glu Leu Pro Lys Asn 
    610                 615                 620                 


Ser Gly Glu Ser Asn Glu Asn Trp Leu Tyr Met Gly Lys Thr Ser Asp 
625                 630                 635                 640 


Glu Ala Lys Arg Asn Val Met Asn His Ile Asn Asn Glu Arg Met Asn 
                645                 650                 655     


Gly Phe Asn Gly Tyr Phe Gly Glu Glu Glu Gly Lys Asn Asn Gly Asn 
            660                 665                 670         


Leu Asn Val Thr Phe Lys Gly Lys Ser Glu Gln Asn Arg Phe Leu Leu 
        675                 680                 685             


Thr Gly Gly Thr Asn Leu Asn Gly Asp Leu Lys Val Glu Lys Gly Thr 
    690                 695                 700                 


Leu Phe Leu Ser Gly Arg Pro Thr Pro His Ala Arg Asp Ile Ala Gly 
705                 710                 715                 720 


Ile Ser Ser Thr Lys Lys Asp Gln His Phe Ala Glu Asn Asn Glu Val 
                725                 730                 735     


Val Val Glu Asp Asp Trp Ile Asn Arg Asn Phe Lys Ala Thr Asn Ile 
            740                 745                 750         


Asn Val Thr Asn Asn Ala Thr Leu Tyr Ser Gly Arg Asn Val Ala Asn 
        755                 760                 765             


Ile Thr Ser Asn Ile Thr Ala Ser Asp Asn Ala Lys Val His Ile Gly 
    770                 775                 780                 


Tyr Lys Ala Gly Asp Thr Val Cys Val Arg Ser Asp Tyr Thr Gly Tyr 
785                 790                 795                 800 


Val Thr Cys Thr Thr Asp Lys Leu Ser Asp Lys Ala Leu Asn Ser Phe 
                805                 810                 815     


Asn Ala Thr Asn Val Ser Gly Asn Val Asn Leu Ser Gly Asn Ala Asn 
            820                 825                 830         


Phe Val Leu Gly Lys Ala Asn Leu Phe Gly Thr Ile Ser Gly Thr Gly 
        835                 840                 845             


Asn Ser Gln Val Arg Leu Thr Glu Asn Ser His Trp His Leu Thr Gly 
    850                 855                 860                 


Asp Ser Asn Val Asn Gln Leu Asn Leu Asp Lys Gly His Ile His Leu 
865                 870                 875                 880 


Asn Ala Gln Asn Asp Ala Asn Lys Val Thr Thr Tyr Asn Thr Leu Thr 
                885                 890                 895     


Val Asn Ser Leu Ser Gly Asn Gly Ser Phe Tyr Tyr Leu Thr Asp Leu 
            900                 905                 910         


Ser Asn Lys Gln Gly Asp Lys Val Val Val Thr Lys Ser Ala Thr Gly 
        915                 920                 925             


Asn Phe Thr Leu Gln Val Ala Asp Lys Thr Gly Glu Pro Thr Lys Asn 
    930                 935                 940                 


Glu Leu Thr Leu Phe Asp Ala Ser Asn Ala Thr Arg Asn Asn Leu Asn 
945                 950                 955                 960 


Val Ser Leu Val Gly Asn Thr Val Asp Leu Gly Ala Trp Lys Tyr Lys 
                965                 970                 975     


Leu Arg Asn Val Asn Gly Arg Tyr Asp Leu Tyr Asn Pro Glu Val Glu 
            980                 985                 990         


Lys Arg Asn Gln Thr Val Asp Thr  Thr Asn Ile Thr Thr  Pro Asn Asn 
        995                 1000                 1005             


Ile Gln  Ala Asp Val Pro 
    1010                 


<210>  25
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  6xHis tag

<400>  25

His His His His His His 
1               5       


<210>  26
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  encodes 6xHis tag

<400>  26
caccatcacc atcaccat                                                     18


<210>  27
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  c-myc epitope tag

<400>  27

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  28
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  encodes c-myc epitope tag

<400>  28
gagcaaaagc tcatttctga agaggacttg                                        30


<210>  29
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  hemagglutinin epitope tag

<400>  29

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  30
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  encodes hemagglutinin epitope tag

<400>  30
tacccttatg atgtgccaga ttatgcc                                           27


<210>  31
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  VSV-G (vesicular stomatitis virus G) epitope tag

<400>  31

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  32
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(33)
<223>  encodes VSV-G (vesicular stomatitus virus G) epitope tag

<400>  32
tatacagaca tagagatgaa ccgacttgga aag                                    33


<210>  33
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  herpes simplex virus (HSV) epitope tag

<400>  33

Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp 
1               5                   10      


<210>  34
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(33)
<223>  encodes herpes simplex virus (HSV) epitope tag

<400>  34
cagccagaac tcgccccgga agaccccgag gat                                    33


<210>  35
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  V5 epitope tag from simian virus

<400>  35

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  36
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  encodes V5 epitope tag from simian virus

<400>  36
ggcaaaccaa tcccaaaccc actgctgggc ctggatagta ct                          42


<210>  37
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  FLAG epitope tag

<400>  37

Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
1               5                   


<210>  38
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  encodes FLAG epitope tag

<400>  38
gattacaaag acgatgacga taaagga                                           27


<210>  39
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  portion of inhibitor that binds elastase

<400>  39

Cys Thr Leu Glu Tyr 
1               5   


<210>  40
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Residues 229-232 of hinge region of IgA1 molecule

<400>  40

Pro Ser Pro Ser 
1               


<210>  41
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Residues 229-233 of hinge region of IgA1 molecule

<400>  41

Pro Ser Pro Ser Thr 
1               5   


<210>  42
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Consensus furin cleavage site

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa = Ala, Asn, Arg, Asp, Cys, Gln,  Glu, Gly, Phe, His, Ile, 
       Leu, Lys, Met, Pro, Ser, Thr, Trp, Tyr, or Val

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = Arg or Lys

<400>  42

Arg Xaa Xaa Arg 
1               


<210>  43
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Factor Xa cleavage site

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa = Glu or Asp

<400>  43

Glu Xaa Cys Arg 
1               


<210>  44
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  enterokinase cleavage site

<400>  44

Asp Asp Asp Asp Lys 
1               5   


<210>  45
<211>  12
<212>  PRT
<213>  Haemophilus influenzae


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  residues 792-803 of H. influenzae Rd IgA1 protease

<400>  45

Cys Val Arg Ser Asp Tyr Thr Gly Tyr Val Thr Cys 
1               5                   10          


