                         SEQUENCE LISTING

<110>  Singh, Juswinder
       Ghosh, Shomir
       Kluge, Arthur
       Petter, Russell
       Tester, Richland
 
<120>  HETEROARYL COMPOUNDS AND USES THEREOF

<130>  2007878-0088

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Thr Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Thr Cys Val 
    50                  55                  60                  


Glu Thr Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala 
        195                 200                 205             


Ala Pro Val Ser Thr Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Thr Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Thr Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Thr Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Thr Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe 
            340                 345                 350         


Ser Thr Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly 
        355                 360                 365             


Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys Asn Ala 
    370                 375                 380                 


Pro Ser Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys 
385                 390                 395                 400 


Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val 
                405                 410                 415     


Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile 
            420                 425                 430         


Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val 
        435                 440                 445             


Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys 
    450                 455                 460                 


Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly 
465                 470                 475                 480 


Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln 
                485                 490                 495     


Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu 
            500                 505                 510         


Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
        515                 520                 525             


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe 
    530                 535                 540 


<210>  2
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Phe Asn Thr Ile Leu Glu Glu Ile Leu Ile Lys Arg Ser Gln 
1               5                   10                  15      


Gln Lys Lys Lys Thr Ser Pro Leu Asn Tyr Lys Glu Arg Leu Phe Val 
            20                  25                  30          


Leu Thr Lys Ser Met Leu Thr Tyr Tyr Glu Gly Arg Ala Glu Lys Lys 
        35                  40                  45              


Tyr Arg Lys Gly Phe Ile Asp Val Ser Lys Ile Lys Cys Val Glu Ile 
    50                  55                  60                  


Val Lys Asn Asp Asp Gly Val Ile Pro Cys Gln Asn Lys Tyr Pro Phe 
65                  70                  75                  80  


Gln Val Val His Asp Ala Asn Thr Leu Tyr Ile Phe Ala Pro Ser Pro 
                85                  90                  95      


Gln Ser Arg Asp Leu Trp Val Lys Lys Leu Lys Glu Glu Ile Lys Asn 
            100                 105                 110         


Asn Asn Asn Ile Met Ile Lys Tyr His Pro Lys Phe Trp Thr Asp Gly 
        115                 120                 125             


Ser Tyr Gln Cys Cys Arg Gln Thr Glu Lys Leu Ala Pro Gly Cys Glu 
    130                 135                 140                 


Lys Tyr Asn Leu Phe Glu Ser Ser Ile Arg Lys Ala Leu Pro Pro Ala 
145                 150                 155                 160 


Pro Glu Thr Lys Lys Arg Arg Pro Pro Pro Pro Ile Pro Leu Glu Glu 
                165                 170                 175     


Glu Asp Asn Ser Glu Glu Ile Val Val Ala Met Tyr Asp Phe Gln Ala 
            180                 185                 190         


Ala Glu Gly His Asp Leu Arg Leu Glu Arg Gly Gln Glu Tyr Leu Ile 
        195                 200                 205             


Leu Glu Lys Asn Asp Val His Trp Trp Arg Ala Arg Asp Lys Tyr Gly 
    210                 215                 220                 


Asn Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Gly Lys Lys Ser Asn 
225                 230                 235                 240 


Asn Leu Asp Gln Tyr Glu Trp Tyr Cys Arg Asn Met Asn Arg Ser Lys 
                245                 250                 255     


Ala Glu Gln Leu Leu Arg Ser Glu Asp Lys Glu Gly Gly Phe Met Val 
            260                 265                 270         


Arg Asp Ser Ser Gln Pro Gly Leu Tyr Thr Val Ser Leu Tyr Thr Lys 
        275                 280                 285             


Phe Gly Gly Glu Gly Ser Ser Gly Phe Arg His Tyr His Ile Lys Glu 
    290                 295                 300                 


Thr Thr Thr Ser Pro Lys Lys Tyr Tyr Leu Ala Glu Lys His Ala Phe 
305                 310                 315                 320 


Gly Ser Ile Pro Glu Ile Ile Glu Tyr His Lys His Asn Ala Ala Gly 
                325                 330                 335     


Leu Val Thr Arg Leu Arg Tyr Pro Val Ser Val Lys Gly Lys Asn Ala 
            340                 345                 350         


Pro Thr Thr Ala Gly Phe Ser Tyr Glu Lys Trp Glu Ile Asn Pro Ser 
        355                 360                 365             


Glu Leu Thr Phe Met Arg Glu Leu Gly Ser Gly Leu Phe Gly Val Val 
    370                 375                 380                 


Arg Leu Gly Lys Trp Arg Ala Gln Tyr Lys Val Ala Ile Lys Ala Ile 
385                 390                 395                 400 


Arg Glu Gly Ala Met Cys Glu Glu Asp Phe Ile Glu Glu Ala Lys Val 
                405                 410                 415     


Met Met Lys Leu Thr His Pro Lys Leu Val Gln Leu Tyr Gly Val Cys 
            420                 425                 430         


Thr Gln Gln Lys Pro Ile Tyr Ile Val Thr Glu Phe Met Glu Arg Gly 
        435                 440                 445             


Cys Leu Leu Asn Phe Leu Arg Gln Arg Gln Gly His Phe Ser Arg Asp 
    450                 455                 460                 


Val Leu Leu Ser Met Cys Gln Asp Val Cys Glu Gly Met Glu Tyr Leu 
465                 470                 475                 480 


Glu Arg Asn Ser Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
                485                 490                 495     


Val Ser Glu Ala Gly Val Val Lys Val Ser Asp Phe Gly Met Ala Arg 
            500                 505                 510         


Tyr Val Leu Asp Asp Gln Tyr Thr Ser Ser Ser Gly Ala Lys Phe Pro 
        515                 520                 525             


Val Lys Trp Cys Pro Pro Glu Val Phe Asn Tyr Ser Arg Phe Ser Ser 
    530                 535                 540                 


Lys Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Val Phe Thr 
545                 550                 555                 560 


Glu Gly Arg Met Pro Phe Glu Lys Tyr Thr Asn Tyr Glu Val Val Thr 
                565                 570                 575     


Met Val Thr Arg Gly His Arg Leu Tyr Gln Pro Lys Leu Ala Ser Asn 
            580                 585                 590         


Tyr Val Tyr Glu Val Met Leu Arg Cys Trp Gln Glu Lys Pro Glu Gly 
        595                 600                 605             


Arg Pro Ser Phe Glu Asp Leu Leu Arg Thr Ile Asp Glu Leu Val Glu 
    610                 615                 620                 


Cys Glu Glu Thr Phe Gly Arg 
625                 630     


<210>  3
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asn Asn Phe Ile Leu Leu Glu Glu Gln Leu Ile Lys Lys Ser Gln 
1               5                   10                  15      


Gln Lys Arg Arg Thr Ser Pro Ser Asn Phe Lys Val Arg Phe Phe Val 
            20                  25                  30          


Leu Thr Lys Ala Ser Leu Ala Tyr Phe Glu Asp Arg His Gly Lys Lys 
        35                  40                  45              


Arg Thr Leu Lys Gly Ser Ile Glu Leu Ser Arg Ile Lys Cys Val Glu 
    50                  55                  60                  


Ile Val Lys Ser Asp Ile Ser Ile Pro Cys His Tyr Lys Tyr Pro Phe 
65                  70                  75                  80  


Gln Val Val His Asp Asn Tyr Leu Leu Tyr Val Phe Ala Pro Asp Arg 
                85                  90                  95      


Glu Ser Arg Gln Arg Trp Val Leu Ala Leu Lys Glu Glu Thr Arg Asn 
            100                 105                 110         


Asn Asn Ser Leu Val Pro Lys Tyr His Pro Asn Phe Trp Met Asp Gly 
        115                 120                 125             


Lys Trp Arg Cys Cys Ser Gln Leu Glu Lys Leu Ala Thr Gly Cys Ala 
    130                 135                 140                 


Gln Tyr Asp Pro Thr Lys Asn Ala Ser Lys Lys Pro Leu Pro Pro Thr 
145                 150                 155                 160 


Pro Glu Asp Asn Arg Arg Pro Leu Trp Glu Pro Glu Glu Thr Val Val 
                165                 170                 175     


Ile Ala Leu Tyr Asp Tyr Gln Thr Asn Asp Pro Gln Glu Leu Ala Leu 
            180                 185                 190         


Arg Arg Asn Glu Glu Tyr Cys Leu Leu Asp Ser Ser Glu Ile His Trp 
        195                 200                 205             


Trp Arg Val Gln Asp Arg Asn Gly His Glu Gly Tyr Val Pro Ser Ser 
    210                 215                 220                 


Tyr Leu Val Glu Lys Ser Pro Asn Asn Leu Glu Thr Tyr Glu Trp Tyr 
225                 230                 235                 240 


Asn Lys Ser Ile Ser Arg Asp Lys Ala Glu Lys Leu Leu Leu Asp Thr 
                245                 250                 255     


Gly Lys Glu Gly Ala Phe Met Val Arg Asp Ser Arg Thr Ala Gly Thr 
            260                 265                 270         


Tyr Thr Val Ser Val Phe Thr Lys Ala Val Val Ser Glu Asn Asn Pro 
        275                 280                 285             


Cys Ile Lys His Tyr His Ile Lys Glu Thr Asn Asp Asn Pro Lys Arg 
    290                 295                 300                 


Tyr Tyr Val Ala Glu Lys Tyr Val Phe Asp Ser Ile Pro Leu Leu Ile 
305                 310                 315                 320 


Asn Tyr His Gln His Asn Gly Gly Gly Leu Val Thr Arg Leu Arg Tyr 
                325                 330                 335     


Pro Val Cys Phe Gly Arg Gln Lys Ala Pro Val Thr Ala Gly Leu Arg 
            340                 345                 350         


Tyr Gly Lys Trp Val Ile Asp Pro Ser Glu Leu Thr Phe Val Gln Glu 
        355                 360                 365             


Ile Gly Ser Gly Gln Phe Gly Leu Val His Leu Gly Tyr Trp Leu Asn 
    370                 375                 380                 


Lys Asp Lys Val Ala Ile Lys Thr Ile Arg Glu Gly Ala Met Ser Glu 
385                 390                 395                 400 


Glu Asp Phe Ile Glu Glu Ala Glu Val Met Met Lys Leu Ser His Pro 
                405                 410                 415     


Lys Leu Val Gln Leu Tyr Gly Val Cys Leu Glu Gln Ala Pro Ile Cys 
            420                 425                 430         


Leu Val Phe Glu Phe Met Glu His Gly Cys Leu Ser Asp Tyr Leu Arg 
        435                 440                 445             


Thr Gln Arg Gly Leu Phe Ala Ala Glu Thr Leu Leu Gly Met Cys Leu 
    450                 455                 460                 


Asp Val Cys Glu Gly Met Ala Tyr Leu Glu Glu Ala Cys Val Ile His 
465                 470                 475                 480 


Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn Gln Val Ile 
                485                 490                 495     


Lys Val Ser Asp Phe Gly Met Thr Arg Phe Val Leu Asp Asp Gln Tyr 
            500                 505                 510         


Thr Ser Ser Thr Gly Thr Lys Phe Pro Val Lys Trp Ala Ser Pro Glu 
        515                 520                 525             


Val Phe Ser Phe Ser Arg Tyr Ser Ser Lys Ser Asp Val Trp Ser Phe 
    530                 535                 540                 


Gly Val Leu Met Trp Glu Val Phe Ser Glu Gly Lys Ile Pro Tyr Glu 
545                 550                 555                 560 


Asn Arg Ser Asn Ser Glu Val Val Glu Asp Ile Ser Thr Gly Phe Arg 
                565                 570                 575     


Leu Tyr Lys Pro Arg Leu Ala Ser Thr His Val Tyr Gln Ile Met Asn 
            580                 585                 590         


His Cys Trp Lys Glu Arg Pro Glu Asp Arg Pro Ala Phe Ser Arg Leu 
        595                 600                 605             


Leu Arg Gln Leu Ala Glu Ile Ala Glu Ser Gly Leu 
    610                 615                 620 


<210>  4
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Thr Lys Ser Ile Leu Glu Glu Leu Leu Leu Lys Arg Ser Gln 
1               5                   10                  15      


Gln Lys Lys Lys Met Ser Pro Asn Asn Tyr Lys Glu Arg Leu Phe Val 
            20                  25                  30          


Leu Thr Lys Thr Asn Leu Ser Tyr Tyr Glu Tyr Asp Lys Met Lys Arg 
        35                  40                  45              


Gly Ser Arg Lys Gly Ser Ile Glu Ile Lys Lys Ile Arg Cys Val Glu 
    50                  55                  60                  


Lys Val Asn Leu Glu Glu Gln Thr Pro Val Glu Arg Gln Tyr Pro Phe 
65                  70                  75                  80  


Gln Ile Val Tyr Lys Asp Gly Leu Leu Tyr Val Tyr Ala Ser Asn Glu 
                85                  90                  95      


Glu Ser Arg Ser Gln Trp Leu Lys Ala Leu Gln Lys Glu Ile Arg Gly 
            100                 105                 110         


Asn Pro His Leu Leu Val Lys Tyr His Ser Gly Phe Phe Val Asp Gly 
        115                 120                 125             


Lys Phe Leu Cys Cys Gln Gln Ser Cys Lys Ala Ala Pro Gly Cys Thr 
    130                 135                 140                 


Leu Trp Glu Ala Tyr Ala Asn Leu His Thr Ala Val Asn Glu Glu Lys 
145                 150                 155                 160 


His Arg Val Pro Thr Phe Pro Asp Arg Val Leu Lys Ile Pro Arg Ala 
                165                 170                 175     


Val Pro Val Leu Lys Met Asp Ala Pro Ser Ser Ser Thr Thr Leu Ala 
            180                 185                 190         


Gln Tyr Asp Asn Glu Ser Lys Lys Asn Tyr Gly Ser Gln Pro Pro Ser 
        195                 200                 205             


Ser Ser Thr Ser Leu Ala Gln Tyr Asp Ser Asn Ser Lys Lys Ile Tyr 
    210                 215                 220                 


Gly Ser Gln Pro Asn Phe Asn Met Gln Tyr Ile Pro Arg Glu Asp Phe 
225                 230                 235                 240 


Pro Asp Trp Trp Gln Val Arg Lys Leu Lys Ser Ser Ser Ser Ser Glu 
                245                 250                 255     


Asp Val Ala Ser Ser Asn Gln Lys Glu Arg Asn Val Asn His Thr Thr 
            260                 265                 270         


Ser Lys Ile Ser Trp Glu Phe Pro Glu Ser Ser Ser Ser Glu Glu Glu 
        275                 280                 285             


Glu Asn Leu Asp Asp Tyr Asp Trp Phe Ala Gly Asn Ile Ser Arg Ser 
    290                 295                 300                 


Gln Ser Glu Gln Leu Leu Arg Gln Lys Gly Lys Glu Gly Ala Phe Met 
305                 310                 315                 320 


Val Arg Asn Ser Ser Gln Val Gly Met Tyr Thr Val Ser Leu Phe Ser 
                325                 330                 335     


Lys Ala Val Asn Asp Lys Lys Gly Thr Val Lys His Tyr His Val His 
            340                 345                 350         


Thr Asn Ala Glu Asn Lys Leu Tyr Leu Ala Glu Asn Tyr Cys Phe Asp 
        355                 360                 365             


Ser Ile Pro Lys Leu Ile His Tyr His Gln His Asn Ser Ala Gly Met 
    370                 375                 380                 


Ile Thr Arg Leu Arg His Pro Val Ser Thr Lys Ala Asn Lys Val Pro 
385                 390                 395                 400 


Asp Ser Val Ser Leu Gly Asn Gly Ile Trp Glu Leu Lys Arg Glu Glu 
                405                 410                 415     


Ile Thr Leu Leu Lys Glu Leu Gly Ser Gly Gln Phe Gly Val Val Gln 
            420                 425                 430         


Leu Gly Lys Trp Lys Gly Gln Tyr Asp Val Ala Val Lys Met Ile Lys 
        435                 440                 445             


Glu Gly Ser Met Ser Glu Asp Glu Phe Phe Gln Glu Ala Gln Thr Met 
    450                 455                 460                 


Met Lys Leu Ser His Pro Lys Leu Val Lys Phe Tyr Gly Val Cys Ser 
465                 470                 475                 480 


Lys Glu Tyr Pro Ile Tyr Ile Val Thr Glu Tyr Ile Ser Asn Gly Cys 
                485                 490                 495     


Leu Leu Asn Tyr Leu Arg Ser His Gly Lys Gly Leu Glu Pro Ser Gln 
            500                 505                 510         


Leu Leu Glu Met Cys Tyr Asp Val Cys Glu Gly Met Ala Phe Leu Glu 
        515                 520                 525             


Ser His Gln Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val 
    530                 535                 540                 


Asp Arg Asp Leu Cys Val Lys Val Ser Asp Phe Gly Met Thr Arg Tyr 
545                 550                 555                 560 


Val Leu Asp Asp Gln Tyr Val Ser Ser Val Gly Thr Lys Phe Pro Val 
                565                 570                 575     


Lys Trp Ser Ala Pro Glu Val Phe His Tyr Phe Lys Tyr Ser Ser Lys 
            580                 585                 590         


Ser Asp Val Trp Ala Phe Gly Ile Leu Met Trp Glu Val Phe Ser Leu 
        595                 600                 605             


Gly Lys Gln Pro Tyr Asp Leu Tyr Asp Asn Ser Gln Val Val Leu Lys 
    610                 615                 620                 


Val Ser Gln Gly His Arg Leu Tyr Arg Pro His Leu Ala Ser Asp Thr 
625                 630                 635                 640 


Ile Tyr Gln Ile Met Tyr Ser Cys Trp His Glu Leu Pro Glu Lys Arg 
                645                 650                 655     


Pro Thr Phe Gln Gln Leu Leu Ser Ser Ile Glu Pro Leu Arg Glu Lys 
            660                 665                 670         


Asp Lys His 
        675 


<210>  5
<211>  1124
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Pro Pro Ser Glu Glu Thr Pro Leu Ile Pro Gln Arg Ser Cys 
1               5                   10                  15      


Ser Leu Leu Ser Thr Glu Ala Gly Ala Leu His Val Leu Leu Pro Ala 
            20                  25                  30          


Arg Gly Pro Gly Pro Pro Gln Arg Leu Ser Phe Ser Phe Gly Asp His 
        35                  40                  45              


Leu Ala Glu Asp Leu Cys Val Gln Ala Ala Lys Ala Ser Gly Ile Leu 
    50                  55                  60                  


Pro Val Tyr His Ser Leu Phe Ala Leu Ala Thr Glu Asp Leu Ser Cys 
65                  70                  75                  80  


Trp Phe Pro Pro Ser His Ile Phe Ser Val Glu Asp Ala Ser Thr Gln 
                85                  90                  95      


Val Leu Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Asn Trp Phe Gly Leu 
            100                 105                 110         


Glu Lys Cys His Arg Phe Gly Leu Arg Lys Asp Leu Ala Ser Ala Ile 
        115                 120                 125             


Leu Asp Leu Pro Val Leu Glu His Leu Phe Ala Gln His Arg Ser Asp 
    130                 135                 140                 


Leu Val Ser Gly Arg Leu Pro Val Gly Leu Ser Leu Lys Glu Gln Gly 
145                 150                 155                 160 


Glu Cys Leu Ser Leu Ala Val Leu Asp Leu Ala Arg Met Ala Arg Glu 
                165                 170                 175     


Gln Ala Gln Arg Pro Gly Glu Leu Leu Lys Thr Val Ser Tyr Lys Ala 
            180                 185                 190         


Cys Leu Pro Pro Ser Leu Arg Asp Leu Ile Gln Gly Leu Ser Phe Val 
        195                 200                 205             


Thr Arg Arg Arg Ile Arg Arg Thr Val Arg Arg Ala Leu Arg Arg Val 
    210                 215                 220                 


Ala Ala Cys Gln Ala Asp Arg His Ser Leu Met Ala Lys Tyr Ile Met 
225                 230                 235                 240 


Asp Leu Glu Arg Leu Asp Pro Ala Gly Ala Ala Glu Thr Phe His Val 
                245                 250                 255     


Gly Leu Pro Gly Ala Leu Gly Gly His Asp Gly Leu Gly Leu Leu Arg 
            260                 265                 270         


Val Ala Gly Asp Gly Gly Ile Ala Trp Thr Gln Gly Glu Gln Glu Val 
        275                 280                 285             


Leu Gln Pro Phe Cys Asp Phe Pro Glu Ile Val Asp Ile Ser Ile Lys 
    290                 295                 300                 


Gln Ala Pro Arg Val Gly Pro Ala Gly Glu His Arg Leu Val Thr Val 
305                 310                 315                 320 


Thr Arg Thr Asp Asn Gln Ile Leu Glu Ala Glu Phe Pro Gly Leu Pro 
                325                 330                 335     


Glu Ala Leu Ser Phe Val Ala Leu Val Asp Gly Tyr Phe Arg Leu Thr 
            340                 345                 350         


Thr Asp Ser Gln His Phe Phe Cys Lys Glu Val Ala Pro Pro Arg Leu 
        355                 360                 365             


Leu Glu Glu Val Ala Glu Gln Cys His Gly Pro Ile Thr Leu Asp Phe 
    370                 375                 380                 


Ala Ile Asn Lys Leu Lys Thr Gly Gly Ser Arg Pro Gly Ser Tyr Val 
385                 390                 395                 400 


Leu Arg Arg Ser Pro Gln Asp Phe Asp Ser Phe Leu Leu Thr Val Cys 
                405                 410                 415     


Val Gln Asn Pro Leu Gly Pro Asp Tyr Lys Gly Cys Leu Ile Arg Arg 
            420                 425                 430         


Ser Pro Thr Gly Thr Phe Leu Leu Val Gly Leu Ser Arg Pro His Ser 
        435                 440                 445             


Ser Leu Arg Glu Leu Leu Ala Thr Cys Trp Asp Gly Gly Leu His Val 
    450                 455                 460                 


Asp Gly Val Ala Val Thr Leu Thr Ser Cys Cys Ile Pro Arg Pro Lys 
465                 470                 475                 480 


Glu Lys Ser Asn Leu Ile Val Val Gln Arg Gly His Ser Pro Pro Thr 
                485                 490                 495     


Ser Ser Leu Val Gln Pro Gln Ser Gln Tyr Gln Leu Ser Gln Met Thr 
            500                 505                 510         


Phe His Lys Ile Pro Ala Asp Ser Leu Glu Trp His Glu Asn Leu Gly 
        515                 520                 525             


His Gly Ser Phe Thr Lys Ile Tyr Arg Gly Cys Arg His Glu Val Val 
    530                 535                 540                 


Asp Gly Glu Ala Arg Lys Thr Glu Val Leu Leu Lys Val Met Asp Ala 
545                 550                 555                 560 


Lys His Lys Asn Cys Met Glu Ser Phe Leu Glu Ala Ala Ser Leu Met 
                565                 570                 575     


Ser Gln Val Ser Tyr Arg His Leu Val Leu Leu His Gly Val Cys Met 
            580                 585                 590         


Ala Gly Asp Ser Thr Met Val Gln Glu Phe Val His Leu Gly Ala Ile 
        595                 600                 605             


Asp Met Tyr Leu Arg Lys Arg Gly His Leu Val Pro Ala Ser Trp Lys 
    610                 615                 620                 


Leu Gln Val Val Lys Gln Leu Ala Tyr Ala Leu Asn Tyr Leu Glu Asp 
625                 630                 635                 640 


Lys Gly Leu Pro His Gly Asn Val Ser Ala Arg Lys Val Leu Leu Ala 
                645                 650                 655     


Arg Glu Gly Ala Asp Gly Ser Pro Pro Phe Ile Lys Leu Ser Asp Pro 
            660                 665                 670         


Gly Val Ser Pro Ala Val Leu Ser Leu Glu Met Leu Thr Asp Arg Ile 
        675                 680                 685             


Pro Trp Val Ala Pro Glu Cys Leu Arg Glu Ala Gln Thr Leu Ser Leu 
    690                 695                 700                 


Glu Ala Asp Lys Trp Gly Phe Gly Ala Thr Val Trp Glu Val Phe Ser 
705                 710                 715                 720 


Gly Val Thr Met Pro Ile Ser Ala Leu Asp Pro Ala Lys Lys Leu Gln 
                725                 730                 735     


Phe Tyr Glu Asp Arg Gln Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu 
            740                 745                 750         


Ala Leu Leu Ile Gln Gln Cys Met Ala Tyr Glu Pro Val Gln Arg Pro 
        755                 760                 765             


Ser Phe Arg Ala Val Ile Arg Asp Leu Asn Ser Leu Ile Ser Ser Asp 
    770                 775                 780                 


Tyr Glu Leu Leu Ser Asp Pro Thr Pro Gly Ala Leu Ala Pro Arg Asp 
785                 790                 795                 800 


Gly Leu Trp Asn Gly Ala Gln Leu Tyr Ala Cys Gln Asp Pro Thr Ile 
                805                 810                 815     


Phe Glu Glu Arg His Leu Lys Tyr Ile Ser Gln Leu Gly Lys Gly Asn 
            820                 825                 830         


Phe Gly Ser Val Glu Leu Cys Arg Tyr Asp Pro Leu Gly Asp Asn Thr 
        835                 840                 845             


Gly Ala Leu Val Ala Val Lys Gln Leu Gln His Ser Gly Pro Asp Gln 
    850                 855                 860                 


Gln Arg Asp Phe Gln Arg Glu Ile Gln Ile Leu Lys Ala Leu His Ser 
865                 870                 875                 880 


Asp Phe Ile Val Lys Tyr Arg Gly Val Ser Tyr Gly Pro Gly Arg Gln 
                885                 890                 895     


Ser Leu Arg Leu Val Met Glu Tyr Leu Pro Ser Gly Cys Leu Arg Asp 
            900                 905                 910         


Phe Leu Gln Arg His Arg Ala Arg Leu Asp Ala Ser Arg Leu Leu Leu 
        915                 920                 925             


Tyr Ser Ser Gln Ile Cys Lys Gly Met Glu Tyr Leu Gly Ser Arg Arg 
    930                 935                 940                 


Cys Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Glu Ser Glu 
945                 950                 955                 960 


Ala His Val Lys Ile Ala Asp Phe Gly Leu Ala Lys Leu Leu Pro Leu 
                965                 970                 975     


Asp Lys Asp Tyr Tyr Val Val Arg Glu Pro Gly Gln Ser Pro Ile Phe 
            980                 985                 990         


Trp Tyr Ala Pro Glu Ser Leu Ser  Asp Asn Ile Phe Ser  Arg Gln Ser 
        995                 1000                 1005             


Asp Val  Trp Ser Phe Gly Val  Val Leu Tyr Glu Leu  Phe Thr Tyr 
    1010                 1015                 1020             


Cys Asp  Lys Ser Cys Ser Pro  Ser Ala Glu Phe Leu  Arg Met Met 
    1025                 1030                 1035             


Gly Cys  Glu Arg Asp Val Pro  Ala Leu Cys Arg Leu  Leu Glu Leu 
    1040                 1045                 1050             


Leu Glu  Glu Gly Gln Arg Leu  Pro Ala Pro Pro Ala  Cys Pro Ala 
    1055                 1060                 1065             


Glu Val  His Glu Leu Met Lys  Leu Cys Trp Ala Pro  Ser Pro Gln 
    1070                 1075                 1080             


Asp Arg  Pro Ser Phe Ser Ala  Leu Gly Pro Gln Leu  Asp Met Leu 
    1085                 1090                 1095             


Trp Ser  Gly Ser Arg Gly Cys  Glu Thr His Ala Phe  Thr Ala His 
    1100                 1105                 1110             


Pro Glu  Gly Lys His His Ser  Leu Ser Phe Ser 
    1115                 1120                 


<210>  6
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ile Leu Ser Ser Tyr Asn Thr Ile Gln Ser Val Phe Cys Cys Cys 
1               5                   10                  15      


Cys Cys Cys Ser Val Gln Lys Arg Gln Met Arg Thr Gln Ile Ser Leu 
            20                  25                  30          


Ser Thr Asp Glu Glu Leu Pro Glu Lys Tyr Thr Gln Arg Arg Arg Pro 
        35                  40                  45              


Trp Leu Ser Gln Leu Ser Asn Lys Lys Gln Ser Asn Thr Gly Arg Val 
    50                  55                  60                  


Gln Pro Ser Lys Arg Lys Pro Leu Pro Pro Leu Pro Pro Ser Glu Val 
65                  70                  75                  80  


Ala Glu Glu Lys Ile Gln Val Lys Ala Leu Tyr Asp Phe Leu Pro Arg 
                85                  90                  95      


Glu Pro Cys Asn Leu Ala Leu Arg Arg Ala Glu Glu Tyr Leu Ile Leu 
            100                 105                 110         


Glu Lys Tyr Asn Pro His Trp Trp Lys Ala Arg Asp Arg Leu Gly Asn 
        115                 120                 125             


Glu Gly Leu Ile Pro Ser Asn Tyr Val Thr Glu Asn Lys Ile Thr Asn 
    130                 135                 140                 


Leu Glu Ile Tyr Glu Trp Tyr His Arg Asn Ile Thr Arg Asn Gln Ala 
145                 150                 155                 160 


Glu His Leu Leu Arg Gln Glu Ser Lys Glu Gly Ala Phe Ile Val Arg 
                165                 170                 175     


Asp Ser Arg His Leu Gly Ser Tyr Thr Ile Ser Val Phe Met Gly Ala 
            180                 185                 190         


Arg Arg Ser Thr Glu Ala Ala Ile Lys His Tyr Gln Ile Lys Lys Asn 
        195                 200                 205             


Asp Ser Gly Gln Trp Tyr Val Ala Glu Arg His Ala Phe Gln Ser Ile 
    210                 215                 220                 


Pro Glu Leu Ile Trp Tyr His Gln His Asn Ala Ala Gly Leu Met Thr 
225                 230                 235                 240 


Arg Leu Arg Tyr Pro Val Gly Leu Met Gly Ser Cys Leu Pro Ala Thr 
                245                 250                 255     


Ala Gly Phe Ser Tyr Glu Lys Trp Glu Ile Asp Pro Ser Glu Leu Ala 
            260                 265                 270         


Phe Ile Lys Glu Ile Gly Ser Gly Gln Phe Gly Val Val His Leu Gly 
        275                 280                 285             


Glu Trp Arg Ser His Ile Gln Val Ala Ile Lys Ala Ile Asn Glu Gly 
    290                 295                 300                 


Ser Met Ser Glu Glu Asp Phe Ile Glu Glu Ala Lys Val Met Met Lys 
305                 310                 315                 320 


Leu Ser His Ser Lys Leu Val Gln Leu Tyr Gly Val Cys Ile Gln Arg 
                325                 330                 335     


Lys Pro Leu Tyr Ile Val Thr Glu Phe Met Glu Asn Gly Cys Leu Leu 
            340                 345                 350         


Asn Tyr Leu Arg Glu Asn Lys Gly Lys Leu Arg Lys Glu Met Leu Leu 
        355                 360                 365             


Ser Val Cys Gln Asp Ile Cys Glu Gly Met Glu Tyr Leu Glu Arg Asn 
    370                 375                 380                 


Gly Tyr Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Ser Ser 
385                 390                 395                 400 


Thr Cys Ile Val Lys Ile Ser Asp Phe Gly Met Thr Arg Tyr Val Leu 
                405                 410                 415     


Asp Asp Glu Tyr Val Ser Ser Phe Gly Ala Lys Phe Pro Ile Lys Trp 
            420                 425                 430         


Ser Pro Pro Glu Val Phe Leu Phe Asn Lys Tyr Ser Ser Lys Ser Asp 
        435                 440                 445             


Val Trp Ser Phe Gly Val Leu Met Trp Glu Val Phe Thr Glu Gly Lys 
    450                 455                 460                 


Met Pro Phe Glu Asn Lys Ser Asn Leu Gln Val Val Glu Ala Ile Ser 
465                 470                 475                 480 


Glu Gly Phe Arg Leu Tyr Arg Pro His Leu Ala Pro Met Ser Ile Tyr 
                485                 490                 495     


Glu Val Met Tyr Ser Cys Trp His Glu Lys Pro Glu Gly Arg Pro Thr 
            500                 505                 510         


Phe Ala Glu Leu Leu Arg Ala Val Thr Glu Ile Ala Glu Thr Trp 
        515                 520                 525         


<210>  7
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  7

Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp Tyr Val Arg Glu 
1               5                   10                  15      


His 
    


<210>  8
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Thr Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu 
1               5                   10                  15      


Asn 
    


<210>  9
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Thr Gln Leu Met Pro His Gly Cys Leu Leu Glu Tyr Val His Glu 
1               5                   10                  15      


His 
    


