F1546  EXT28 PCT.ST25.txt
SEQUENCE LISTING

<110> 	CELLECTIS
       	CHOULIKA Andr
	GALETTO Roman
 
<120>  MEGANUCLEASE VARIANTS CLEAVING AT LEAST ONE TARGET IN THE GENOME
	OF A RETROVIRUS AND USES THEREOF

<130>  1546  EXT28 PCT

<160>  372    

<170>  PatentIn version 3.5

<210>  1
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  1

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Gln Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  2
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  2

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  3
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  3

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  4
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  4

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ile Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  5
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  5

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  6
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  6

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Arg Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Asn Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  7
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  7

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Glu Tyr Ser Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  8
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  8

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ala Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Glu Tyr Ser Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Ser Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  9
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  9

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Arg Leu Asn Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Glu Tyr Ser Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  10
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  10

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Cys Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Arg Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  11
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  11

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  12
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  12

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  13
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  13

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp
                165     

<210>  14
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_1.3 target oligonucleotide

<400>  14
tggcatacaa gtttgcagaa ctacgtacgt agttctgcca atcgtctgtc a              51



<210>  15
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_1.5 target oligonucleotide

<400>  15
tggcatacaa gtttgcagaa ctacacacgt agttctgcca atcgtctgtc a              51

<210>  16
<211>  26
<212>  DNA
<213>  artificial sequence
<220>  
<223>  Gal10F primer
<400>  16
gcaactttag tgctgacaca tacagg                                          26

<210>  17
<211>  24
<212>  DNA
<213>  artificial sequence
<220>  
<223>  Gal10R primer
<400>  17
acaaccttga ttggagactt gacc                                            24

<210>  18
<211>  15
<212>  DNA
<213>  artificial sequence
<220>  
<223>  assF primer
<400>  18
ctannnttga ccttt                                                      15

<210>  19
<211>  15
<212>  DNA
<213>  artificial sequence
<220>  
<223>  assR primer
<400>  19
aaaggtcaan nntag                                                      15                  

<210>  20
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_1.4 target oligonucleotide
<400>  20
tggcatacaa gtttcctggc cctggtacca gggccaggca atcgtctgtc a              51


<210>  21
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_1.6 target oligonucleotide

<400>  21
tggcatacaa gtttcctggc cctgacacca gggccaggca atcgtctgtc a              51


<210>  22
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_1.2 target oligonucleotide
<400>  22
tggcatacaa gtttgcagaa ctacgtacca gggccaggca atcgtctgtc a              51


<210>  23
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_1 target oligonucleotide
<400>  23
tggcatacaa gtttgcagaa ctacacacca gggccaggca atcgtctgtc a              51


<210>  24
<211>  59
<212>  DNA
<213>  artificial sequence
<220>  
<223>  preATGCreFor primer
<400>  24
gcataaatta ctatacttct atagacacgc aaacacaaat acacagcggc cttgccacc      59

<210>  25
<211>  48
<212>  DNA
<213>  artificial sequence
<220>  
<223>  ICreIpostRev primer
<400>  25
ggctcgagga gctcgtctag aggatcgctc gagttatcag tcggccgc                  48

<210>  26
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  26

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Arg Ala Ala Asp 
                165     


<210>  27
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  27

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  28
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  28

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Asn 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  29
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  29

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Asn Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  30
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  30

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165     


<210>  31
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  31

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Arg Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  32
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  32

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Arg Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  33
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  33

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Gln Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  34
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  34

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Arg 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  35
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  35

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Arg Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165     


<210>  36
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  36

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu Tyr Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  37
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  37

Met Ala Ser Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Gln Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Arg Ala Ala Asp 
                165     


<210>  38
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  38

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Leu Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Arg 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Glu Leu Val Asp Gly Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165     


<210>  39
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  39

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Arg Ala Ala Asp 
                165     


<210>  40
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  40

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Ala Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Ala Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Arg Ile Lys Pro Leu His Asp Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  41
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  41

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Arg Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Glu Ser Ser Pro Ala Ala Asp 
                165     


<210>  42
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  42

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Arg Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Ile Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Thr Lys Pro Leu His Ser Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Thr Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165     


<210>  43
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  43

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Arg Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Arg Ala Ala Asp 
                165     


<210>  44
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  44

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Tyr Leu Asn 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Glu Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  45
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  45

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Leu Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Gln Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  46
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  46

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     

<210>  47
<211>  33
<212>  DNA
<213>  artificial sequence
<220>  
<223>  G19SF primer
<400>  47
gccggctttg tggactctga cggtagcatc atc                                  33

<210>  48
<211>  33
<212>  DNA
<213>  artificial sequence
<220>  
<223>  G19SR primer
<400>  48
gatgatgcta ccgtcagagt ccacaaagcc ggc                                  33   

<210>  49
<211>  33
<212>  DNA
<213>  artificial sequence
<220>  
<223>  F54LF primer
<400>  49
acccagcgcc gttggctgct ggacaaacta gtg                                  33

<210>  50
<211>  33
<212>  DNA
<213>  artificial sequence
<220>  
<223>  F54LR primer
<400>  50
cactagtttg tccagcagcc aacggcgctg ggt                                  33

<210>  51
<211>  33
<212>  DNA
<213>  artificial sequence
<220>  
<223>  E80KF primer
<400>  51
ttaagcaaaa tcaagccgct gcacaacttc ctg                                  33

<210>  52
<211>  33
<212>  DNA
<213>  artificial sequence
<220>  
<223>  E80KR primer
<400>  52
caggaagttg tgcagcggct tgattttgct taa                                  33


<210>  53
<211>  33
<212>  DNA
<213>  artificial sequence
<220>  
<223>  F87LF primer
<400>  53
aagccgctgc acaacctgct gactcaactg cag                                  33

<210>  54
<211>  33
<212>  DNA
<213>  artificial sequence
<220>  
<223>  F87LR primer
<400>  54
ctgcagttga gtcagcaggt tgtgcagcgg ctt                                  33

<210>  55
<211>  33
<212>  DNA
<213>  artificial sequence
<220>  
<223>  V105AF primer
<400>  55
aaacaggcaa acctggctct gaaaattatc gaa                                  33

<210>  56
<211>  33
<212>  DNA
<213>  artificial sequence
<220>  
<223>  V105AR primer
<400>  56
ttcgataatt ttcagagcca ggtttgcctg ttt                                  33


<210>  57
<211>  33
<212>  DNA
<213>  artificial sequence
<220>  
<223>  I132VF primer
<400>  57
acctgggtgg atcaggttgc agctctgaac gat                                  33

<210>  58
<211>  33
<212>  DNA
<213>  artificial sequence
<220>  
<223>  I132VR primer
<400>  58
atcgttcaga gctgcaacct gatccaccca ggt                                  33

<210>  59
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  59

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Thr Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  60
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  60

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Thr Lys Pro Leu His Asp Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165     


<210>  61
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  61

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Arg 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Arg Ile Lys Pro Leu His Asp Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  62
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  62

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu Tyr Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165     


<210>  63
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3 I-CreI variant

<400>  63

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Arg Ile Lys Pro Leu His Asp Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  64
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3/1.5 I-CreI variant

<400>  64

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Leu Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Arg 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Arg Ile Lys Pro Leu His Asp Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Arg Ala Ala Asp 
                165     


<210>  65
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.3/1.5 I-CreI variant

<400>  65

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Leu Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Arg 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Thr Lys Pro Leu His Asn Leu Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Arg Ala Ala Asp 
                165     


<210>  66
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  66

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ala Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  67
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  67

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Cys Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Arg Ser Ser Pro Ala Ala Asp 
                165     


<210>  68
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  68

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  69
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  69

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Lys Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  70
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  70

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Leu Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Arg Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  71
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  71

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Leu Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  72
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  72

Met Ala Asn Thr Lys Tyr Asp Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Glu Tyr Ser Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Ser Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Asn Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Pro Ser Pro Ala Ala Asp 
                165     


<210>  73
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  73

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Arg Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  74
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  74

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Pro Val Ser Glu Tyr Ser Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Ser Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  75
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  75

Met Ala Asn Ala Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Gly Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  76
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  76

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Lys Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  77
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  77

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Gly Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  78
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  78

Met Ala Asn Thr Lys Tyr Asp Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  79
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  79

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  80
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  80

Met Ala Asn Thr Lys Tyr Asn Lys Val Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Lys Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Arg Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  81
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  81

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Leu Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Leu Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  82
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  82

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Glu Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Asn Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Arg Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  83
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  83

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Tyr Asp Thr Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Gly Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  84
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  84

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Leu Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Asn Lys Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  85
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_1.4 I-CreI variant

<400>  85

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Leu Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     

<210>  86
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_3.3 target oligonucleotide
<400>  86
tggcatacaa gtttctcaga ccctgtacag ggtctgagca atcgtctgtc a              51

<210>  87
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_3.5 target oligonucleotide
<400>  87
tggcatacaa gtttctcaga cccttttaag ggtctgagca atcgtctgtc a              51

<210>  88
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  88

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Tyr Leu Arg Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Asn Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  89
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  89

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Cys Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asp Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  90
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  90

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Cys Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  91
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  91

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Gly Gly Ser Val Ser Asn Tyr Leu Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  92
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  92

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Thr Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  93
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  93

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  94
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  94

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Gln Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Glu Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     

<210>  95
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>   HIV1_3.4 target oligonucleotide
<400>  95
tggcatacaa gtttccacac tgacgtacgt cagtgtggca atcgtctgtc a              51

<210>  96
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>   HIV1_3.6 target oligonucleotide
<400>  96
tggcatacaa gtttccacac tgactttagt cagtgtggca atcgtctgtc a              51

<210>  97
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  97

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  98
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  98

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Arg Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  99
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  99

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  100
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  100

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  101
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  101

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  102
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  102

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Glu Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  103
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  103

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  104
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  104

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Arg Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Arg Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  105
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  105

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  106
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  106

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Gly Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Thr Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  107
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  107

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  108
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  108

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Arg Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ser Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  109
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  109

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Asn Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  110
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  110

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Tyr Leu Arg Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Asn Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Val Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  111
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  111

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Tyr Leu Arg Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Asn Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  112
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  112

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Tyr Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  113
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  113

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Cys Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  114
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  114

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Cys Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asp Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  115
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  115

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Arg Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Arg Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  116
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  116

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Thr Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Cys Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  117
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  117

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Leu Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  118
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  118

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Ala Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu Arg Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Cys Leu Ser Glu Gln Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  119
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  119

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Cys Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  120
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  120

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Leu Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Leu Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Cys Pro Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  121
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  121

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu Arg Asn Leu Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Cys Leu Ser Glu Glu Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  122
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  122

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Tyr Leu Arg Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Arg Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  123
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  123

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  124
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  124

Met Ala Ser Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Asn Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  125
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  125

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Arg Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  126
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  126

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Arg Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  127
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  127

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Thr Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Cys Leu Ser Glu Gln Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  128
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  128

Met Ala Asn Thr Lys Tyr Asp Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Ala Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu Arg Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Arg Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  129
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  129

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Thr Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  130
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  130

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Leu Lys Val Thr Gln 
        35                  40                  45              


Lys Ala Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu Arg Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Cys Leu Ser Glu Gln Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  131
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  131

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Arg Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Cys Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  132
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  132

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Thr Ile Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  133
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  133

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Cys Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  134
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  134

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Leu Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Cys Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  135
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.3 I-CreI variant

<400>  135

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Thr Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Arg Pro Phe Leu 
                85                  90                  95      


Arg Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Arg Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  136
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  136

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Arg Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  137
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  137

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  138
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  138

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  139
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  139

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Arg Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Tyr Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  140
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  140

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Arg Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  141
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  141

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  142
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  142

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Gly Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  143
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  143

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Arg Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Cys Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  144
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  144

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Tyr Val Ser Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Arg Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  145
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  145

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Arg Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  146
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  146

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Arg Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Gly Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Gly Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  147
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  147

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Gly Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Arg Ser Ser Pro Ala Ala Asp
                165     


<210>  148
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  148

Met Ala Asn Thr Ile Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  149
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  149

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Cys Leu Thr Phe Tyr Val Ser Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Val Lys Pro Leu His Asn Phe Leu Thr Gln Leu Arg Pro Phe Leu 
                85                  90                  95      


Arg Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  150
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  150

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ser Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  151
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  151

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Arg Phe Lys His Glu Leu Arg Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Tyr Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  152
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  152

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Phe Pro Ala Ala Asp 
                165     


<210>  153
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  153

Met Ala Asn Thr Lys Tyr Asn Arg Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Cys Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Val Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  154
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  154

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Gly Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Arg Ser Ser Pro Ala Ala Asp 
                165     


<210>  155
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  155

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Arg Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Arg Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Lys Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  156
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  156

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  157
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  157

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ser Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Lys Leu Thr Leu Leu Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asn Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  158
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  158

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  159
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  159

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Tyr Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  160
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  160

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  161
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  161

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Glu Leu Arg Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  162
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  162

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Arg Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  163
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  163

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  164
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  164

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  165
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_3.4 I-CreI variant

<400>  165

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     

<210>  166
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 target oligonucleotide

<400>  166
tggcatacaa gtttccagca ttctgtacag aatgctggca atcgtctgtc a              51

<210>  167
<211>  51
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HIV1_4.5 target oligonucleotide

<400>  167
tggcatacaa gtttccagca ttctggacag aatgctggca atcgtctgtc a              51

<210>  168
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  168

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  169
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  169

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Asp Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  170
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  170

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  171
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  171

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  172
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  172

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ala Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  173
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  173

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gly Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  174
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  174

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     

<210>  175
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_4.4 target oligonucleotide
<400>  175
tggcatacaa gtttcttgtc ttatgtacat aagacaagca atcgtctgtc a              51

<210>  176
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_4.6 target oligonucleotide
<400>  176
tggcatacaa gtttcttgtc ttatggacat aagacaagca atcgtctgtc a              51

<210>  177
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  177

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  178
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  178

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Gly Thr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  179
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  179

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  180
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  180

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ala Thr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  181
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  181

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Arg Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  182
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  182

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Ala Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  183
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  183

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Cys Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  184
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  184

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ala Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Arg Leu Lys Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Ala Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  185
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  185

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Ala Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Arg Leu Lys Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Tyr Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  186
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  186

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     

<210>  187
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_4.2 target oligonucleotide
<400>  187
tggcatacaa gtttccagca ttctgtacat aagacaagca atcgtctgtc a              51

<210>  188
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_4 target oligonucleotide
<400>  188
tggcatacaa gtttccagca ttctggacat aagacaagca atcgtctgtc a              51

<210>  189
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  189

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Asn His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  190
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  190

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  191
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  191

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  192
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  192

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  193
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  193

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Met Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  194
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  194

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  195
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  195

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Pro Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  196
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  196

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Asp Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Arg Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  197
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  197

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Leu Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  198
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  198

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  199
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  199

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Arg Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  200
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  200

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Arg Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  201
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  201

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Met Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Met Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  202
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  202

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Ala Asp Ser Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Ser Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  203
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  203

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp
                165     


<210>  204
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  204

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  205
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  205

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  206
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  206

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Asn Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Glu 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  207
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  207

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Gly Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Ala Asp Asp Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Arg Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  208
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  208

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  209
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.3 I-CreI variant

<400>  209

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Cys Lys His Arg Leu Lys Leu Thr Tyr Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Val Gly 
    50                  55                  60                  


Val Gly Tyr Ile Thr Asp Gly Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  210
<400>  210
000

<210>  211
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  211

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  212
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  212

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  213
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  213

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  214
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  214

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Ala Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165     


<210>  215
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  215

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Arg Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Pro Pro Ala Ala Asp 
                165     


<210>  216
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  216

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Met Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Met Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  217
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  217

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Ala Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  218
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  218

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Ser Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu His Pro Tyr Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  219
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  219

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Met Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  220
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  220

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Met Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  221
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  221

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Arg Ser Ser Pro Ala Ala Asp 
                165     


<210>  222
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  222

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Arg Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  223
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  223

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ala Thr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Arg Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Met Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  224
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  224

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala His Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  225
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  225

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  226
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  226

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ala Thr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Arg Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Ala Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  227
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  227

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Arg Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  228
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4.4 I-CreI variant

<400>  228

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Arg Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  229
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  229

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Arg Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  230
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  230

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Gln Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  231
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  231

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  232
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  232

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  233
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  233

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Gln Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Arg Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Arg Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Pro Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  234
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  234

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Gln Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Arg Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Leu Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  235
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  235

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  236
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  236

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Leu Leu Thr Gln Leu Arg Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  237
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  237

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  238
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_4 I-CreI variant

<400>  238

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Gln Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Arg Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Arg Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Arg Ser Ser Pro Ala Ala Asp 
                165     

<210>  239
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>   HIV1_5.3 target oligonucleotide
<400>  239
tggcatacaa gtttgctcta ttaggtacct aatagagcca atcgtctgtc a              51

<210>  240
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>    HIV1_5.5 target oligonucleotide
<400>  240
tggcatacaa gtttgctcta ttagatacct aatagagcca atcgtctgtc a              51


<210>  241
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  241

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  242
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  242

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     

<210>  243
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_5.4 target oligonucleotide
<400>  243
tggcatacaa gtttatctgc tcctgtacag gagcagatca atcgtctgtc a              51

<210>  244
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_5.6 target oligonucleotide
<400>  244
tggcatacaa gtttatctgc tcctatacag gagcagatca atcgtctgtc a              51

<210>  245
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  245

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ala Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  246
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  246

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gln Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Thr Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  247
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  247

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gln Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  248
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  248

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  249
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  249

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  250
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  250

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  251
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  251

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  252
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  252

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Thr Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Ala Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  253
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  253

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     

<210>  254
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_5.2 target oligonucleotide
<400>  254
tggcatacaa gtttgctcta ttaggtacag gagcagatca atcgtctgtc a              51

<210>  255
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_5 target oligonucleotide
<400>  255
tggcatacaa gtttgctcta ttagatacag gagcagatca atcgtctgtc a              51

<210>  256
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  256

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  257
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  257

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Ser Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  258
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  258

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Glu Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asp Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  259
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  259

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  260
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  260

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Ala Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  261
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  261

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  262
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  262

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Gly Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  263
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  263

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  264
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  264

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  265
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  265

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Tyr Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Arg Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  266
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  266

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Glu Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Thr 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asp Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  267
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  267

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Pro Ser Pro Ala Ala Asp 
                165     


<210>  268
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  268

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Phe Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Tyr Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Arg Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Tyr Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Gly Gly Ala Asp 
                165     


<210>  269
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  269

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Gln Gly Tyr Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  270
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  270

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Gln Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  271
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  271

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Ala Leu Ser Leu Thr Phe Asn Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Ser Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  272
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  272

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  273
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  273

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Tyr Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  274
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  274

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Glu Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asp Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Val Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  275
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  275

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Thr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Ala Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  276
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  276

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Thr Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  277
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  277

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Glu Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Thr 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  278
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  278

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Glu Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Thr 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asp Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  279
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  279

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Glu Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Thr 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  280
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  280

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Thr 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  281
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  281

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Gln Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  282
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  282

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Glu Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Thr 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  283
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  283

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Gln Gly Ser Gly Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  284
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  284

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Glu Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Thr 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asp Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  285
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  285

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Gln Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Gln Gly Tyr Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asp Leu Val Leu Lys Val Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  286
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.3 -CreI variant

<400>  286

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Thr 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     

<210>  287
<400>  287
000


<210>  288
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  288

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Val Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  289
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  289

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ala Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ser Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  290
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  290

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Leu Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Arg Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  291
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  291

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asn Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  292
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  292

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Leu Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Arg Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  293
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  293

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  294
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  294

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gln Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Ser Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Ala Leu Asp Ser Leu Ser Glu Lys Arg 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  295
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  295

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Thr Gln 
            20                  25                  30          


Ser Gly Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Phe Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Ala Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  296
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  296

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  297
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  297

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Val Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Arg Lys 
145                 150                 155                 160 


Lys Ser Ser Thr Ala Ala Asp
                165     


<210>  298
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  298

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Thr Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  299
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  299

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Thr Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Arg Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Glu Ser Ser Pro Ala Ala Asp 
                165     


<210>  300
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  300

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Val Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  301
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  301

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Leu Lys Met Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ser Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  302
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  302

Met Ala Tyr Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Leu Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly His Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Glu Pro Leu His Asn Phe Leu Ser Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Ser Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Ala Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  303
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  303

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Leu Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Arg Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Tyr Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  304
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  304

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Leu Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Arg Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  305
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  305

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Leu Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Arg Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Tyr Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165     


<210>  306
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  306

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ala Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly His Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ser Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asp Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Arg Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Val Thr Val Arg Ala Ala Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp
                165     


<210>  307
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  307

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Val Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Arg Lys 
145                 150                 155                 160 


Lys Ser Ser Thr Ala Ala Asp
                165     


<210>  308
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  308

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Thr Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Arg Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Glu Ser Ser Pro Ala Ala Asp
                165     


<210>  309
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  309

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Thr Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Arg Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Glu Ser Ser Pro Ala Ala Asp
                165     


<210>  310
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  310

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Arg 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Val Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Arg Lys 
145                 150                 155                 160 


Lys Ser Ser Thr Ala Ala Asp
                165     


<210>  311
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  311

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Arg Lys 
145                 150                 155                 160 


Lys Ser Ser Thr Thr Ala Asp
                165     


<210>  312
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  312

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Ala Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Thr Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Val Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Arg Lys 
145                 150                 155                 160 


Lys Ser Ser Thr Ala Ala Asp
                165     


<210>  313
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  313

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Thr Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Arg Lys 
145                 150                 155                 160 


Lys Ser Ser Thr Ala Ala Asp
                165     


<210>  314
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  314

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Thr Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Glu Ser Ser Pro Ala Ala Asp
                165     


<210>  315
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  315

Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Asn Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Thr Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Arg Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Glu Ser Ser Pro Ala Ala Asp
                165     


<210>  316
<211>  167
<212>  PRT
<213>  artificial sequence

<220>  
<223>  HIV1_5.4 -CreI variant

<400>  316

Met Ala Asn Thr Lys Tyr Ser Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Val Val Cys Thr 
        115                 120                 125             


Trp Val Asp Arg Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Arg Lys 
145                 150                 155                 160 


Lys Ser Ser Thr Ala Ala Asp
                165     


<210>  317
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_3.2 target oligonucleotide
<400>  317
tggcatacaa gtttctcaga ccctgtacgt cagtgtggca atcgtctgtc a              51

<210>  318
<211>  51
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_3 target oligonucleotide
<400>  318
tggcatacaa gtttctcaga cccttttagt cagtgtggca atcgtctgtc a              51

<210>  319
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_1 target
<400>  319
cagaactaca caccagggcc ag                                              22

<210>  320
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_1.2 target
<400>  320
cagaactacg taccagggcc ag                                              22

<210>  321
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_1.3 target
<400>  321
cagaactacg tacgtagttc tg                                              22

<210>  322
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_1.4 target
<400>  322
ctggccctgg taccagggcc ag                                              22

<210>  323
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_1.5 target
<400>  323
cagaactaca cacgtagttc tg                                              22

<210>  324
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_1.6 target
<400>  324
ctggccctga caccagggcc ag                                              22

<210>  325
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_3 target
<400>  325
tcagaccctt ttagtcagtg tg                                              22

<210>  326
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_3.2 target
<400>  326
tcagaccctg tacgtcagtg tg                                              22

<210>  327
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_3.3 target
<400>  327
tcagaccctg tacagggtct ga                                              22


<210>  328
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_3.4 target
<400>  328
cacactgacg tacgtcagtg tg                                              22

<210>  329
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_3.5 target
<400>  329
tcagaccctt ttaagggtct ga                                              22

<210>  330
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_3.6 target
<400>  330
cacactgact ttagtcagtg tg                                              22

<210>  331
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_4  target
<400>  331
cagcattctg gacataagac aa                                              22

<210>  332
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_4.2  target
<400>  332
cagcattctg tacataagac aa                                              22

<210>  333
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_4.3  target
<400>  333
cagcattctg tacagaatgc tg                                              22

<210>  334
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_4.4  target
<400>  334
ttgtcttatg tacataagac aa                                              22

<210>  335
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_4.5  target
<400>  335
cagcattctg gacagaatgc tg                                              22

<210>  336
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_4.6  target
<400>  336
ttgtcttatg gacataagac aa                                              22

<210>  337
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_5 target
<400>  337
ctctattaga tacaggagca ga                                              22

<210>  338
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_5.2   target
<400>  338
ctctattagg tacaggagca ga                                              22 

<210>  339
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_5.3 target
<400>  339
ctctattagg tacctaatag ag                                              22

<210>  340
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_5.4 target
<400>  340
tctgctcctg tacaggagca ga                                              22

<210>  341
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_5.5 target
<400>  341
ctctattaga tacctaatag ag                                              22

<210>  342
<211>  22
<212>  DNA
<213>  artificial sequence
<220>  
<223>  HIV1_5.6 target
<400>  342
tctgctccta tacaggagca ga                                              22

<210>  343
<211>  24
<212>  DNA
<213>  artificial sequence
<220>  
<223>  C1221 target
<400>  343
tcaaaacgtc gtacgacgtt ttga                                            24

<210>  344
<211>  163
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  344

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser 
            20                  25                  30          


Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys 
145                 150                 155                 160 


Ser Ser Pro 

<210>  345
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  RM2 peptide linker

<400>  345

Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn 
1               5                   10                  15      


Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly Gly Gly Gly Ser 
            20                  25                  30          

<210>  346
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_1-A

<400>  346

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Thr Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Gly Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Ser Leu Thr Phe Val Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser Lys Thr 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  347
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_1-B

<400>  347

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Ala Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Ala Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Arg Ile Lys Pro Leu His Asp Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser Thr 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Gly Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  348
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_1-C

<400>  348

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Ala Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Gly Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Ser Leu Ala Phe Val Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Ala Gly Tyr Val Glu Asp Arg Gly Ser Val Ser Asp Tyr Arg Leu Ser 
65                  70                  75                  80  


Arg Ile Lys Pro Leu His Asp Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Arg Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu His 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser Thr 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Lys Leu Thr Phe Arg Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Asn Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Gly Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  349
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_3-A

<400>  349

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Thr Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Cys Leu Ser Glu Gln Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  350
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_3-B

<400>  350

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Arg Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  351
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_3-C

<400>  351

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Thr Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Cys Leu Ser Glu Gln Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Leu Leu Thr Gln Leu Gln Pro Tyr Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  352
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_3-D

<400>  352

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Leu Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Ser Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Leu Leu Thr Gln Leu Gln Pro Tyr Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  353
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_3-E

<400>  353

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Lys Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Arg Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Ser Leu Thr Leu Tyr Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Ser Asp Arg Gly Ser Val Ser Asp Tyr Val Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  354
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_4-A

<400>  354

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro His Gln 
            20                  25                  30          


Ser Met Lys Phe Lys His Ala Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Thr Asp Gly Gly Ser Val Ser Asn Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Met Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  355
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_5-A

<400>  355

Met Ala Asn Thr Lys Tyr Ser Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Glu Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Thr 
65                  70                  75                  80  


Glu Ile Lys Pro Leu Arg Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Arg Ser Ser 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Val Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Arg Lys Lys Ser 
            340                 345                 350         


Ser Thr 
        


<210>  356
<211>  355
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_5-B

<400>  356

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln 
            20                  25                  30          


Ser Cys Lys Phe Lys His Tyr Leu Ser Leu Thr Phe Ala Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Gln Gly Ser Val Ser Asn Tyr Ile Leu Thr 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Val Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Ser Gln Ser Asn 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Ile Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Asn Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Arg Lys Lys Ser 
            340                 345                 350         


Ser Thr Thr 
        355


<210>  357
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_7-A

<400>  357

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Gly Ser Gly Ser Val Ser Tyr Tyr Ser Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Glu Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu His Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Gln Leu Thr Phe Arg Val Thr Gln Arg Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser Gly Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  358
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_7-B

<400>  358

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Thr Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Ser Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Ile Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu His Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser Cys 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Gln Leu Thr Phe Arg Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  359
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_8-A

<400>  359

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Arg Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Gly Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Asn Asp Ser Gly Ser Met Ser Gln Tyr Cys Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Ser Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Lys Leu Thr Phe Thr Val Thr Gln Lys Thr 
225                 230                 235                 240 


Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Tyr Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Gly Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  360
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_8-B

<400>  360

Met Ala Ser Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val His Asp Ser Gly Ser Val Ser Tyr Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Gly Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Asn Asp Ser Gly Ser Met Ser Gln Tyr Cys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  361
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_8-C

<400>  361

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Thr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Val Ser Tyr Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Gly Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Asn Asp Ser Gly Ser Met Ser Gln Tyr Cys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  362
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_8-D

<400>  362

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Gln Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Arg Leu Lys Leu Thr Phe Thr Val Thr Gln 
        35                  40                  45              


Lys Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Tyr Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Gly Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Lys Val Gly Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Asn Asp Ser Gly Ser Met Ser Gln Tyr Cys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Ser Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  363
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_9-A

<400>  363

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Arg 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Glu Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Asn Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Tyr Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Gln Tyr Val Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  364
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_9-B

<400>  364

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Arg 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Glu Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Asn Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Tyr Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Gln Tyr Val Leu Ser Val Ile 
            260                 265                 270         


Lys Pro Leu His Asn Leu Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Arg Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  365
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH-HIV1_9-C

<400>  365

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Arg 
            20                  25                  30          


Ser His Lys Phe Lys His Gln Leu Gln Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Glu Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Gly Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Asn Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Tyr Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Gln Tyr Val Leu Ser Val Ile 
            260                 265                 270         


Lys Pro Leu His Asn Leu Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Arg Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        
<210>  366
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HIV1_7 target

<400>  366
ggagccaccc cacaagattt aa                                              22

<210>  367
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HIV1_8 target 

<400>  367
gggcccctag gaaaaagggc tg                                              22

<210>  368
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HIV1_9 target 
 
<400>  368
agaaatctgt tgactcagat tg                                              22  

<210>  369
<211>  30
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HI8f primer
   
<400>  369 
gacccggcca taaagcaaga gttttggctg                                      30

<210>  370
<211>  30
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HI8r primer
   
<400>  370 
aagctctctt ctggtggggc tgttggctct                                      30  

<210>  371
<211>  30
<212>  DNA
<213>  artificial sequence

<220>  
<223>  adaptator sequence
   
<400>  371 
ccatctcatc cctgcgtgtc tccgactcag                                      30     

<210>  372
<211>  30
<212>  DNA
<213>  artificial sequence

<220>  
<223>  adaptator sequence
   
<400>  372 
cctatcccct gtgtgccttg gcagtctcag                                      30
