                         SEQUENCE LISTING

<110>  Cytos Biotechnology AG
       Bachmann, Martin F.
       Jegerlehner, Andrea
       Kazaks, Andris
       Link, Alexander
       Lipowsky, Gerd
       Tars, Kaspars
 
<120>  Virus-Like Particles of Bacteriophage  phiCb5

<130>  P1097PC00

<150>  EP 09158634.7
<151>  2009-04-23

<160>  30    

<170>  PatentIn version 3.3

<210>  1
<211>  369
<212>  DNA
<213>  Bacteriophage phi Cb5

<400>  1
atggctctcg gcgacactct tacgatcact cttggtggct ctggcggaac tgccaaagtc     60

ctcaggaaga tcaaccagga cggatatacc tcagagtact acctgcccga aacgagttct    120

tcgttccggg ccaaggtgcg tcacactaag gaatccgtca agccgaacca ggttcagtac    180

gaacgccaca atgtggagtt cactgaaacg gtgtatgcct ctggctctac gcccgagttc    240

gtccgccaag cttacgtcgt catccgccac aaggtgggtg acgtctctgc tactgtttcg    300

gacctcggcg aggcgctttc gttctatctg aacgaagccc tctacgggaa gctcatcggc    360

tgggaatcg                                                            369


<210>  2
<211>  123
<212>  PRT
<213>  Bacteriophage phi Cb5

<400>  2

Met Ala Leu Gly Asp Thr Leu Thr Ile Thr Leu Gly Gly Ser Gly Gly 
1               5                   10                  15      


Thr Ala Lys Val Leu Arg Lys Ile Asn Gln Asp Gly Tyr Thr Ser Glu 
            20                  25                  30          


Tyr Tyr Leu Pro Glu Thr Ser Ser Ser Phe Arg Ala Lys Val Arg His 
        35                  40                  45              


Thr Lys Glu Ser Val Lys Pro Asn Gln Val Gln Tyr Glu Arg His Asn 
    50                  55                  60                  


Val Glu Phe Thr Glu Thr Val Tyr Ala Ser Gly Ser Thr Pro Glu Phe 
65                  70                  75                  80  


Val Arg Gln Ala Tyr Val Val Ile Arg His Lys Val Gly Asp Val Ser 
                85                  90                  95      


Ala Thr Val Ser Asp Leu Gly Glu Ala Leu Ser Phe Tyr Leu Asn Glu 
            100                 105                 110         


Ala Leu Tyr Gly Lys Leu Ile Gly Trp Glu Ser 
        115                 120             


<210>  3
<211>  122
<212>  PRT
<213>  Bacteriophage phi Cb5

<400>  3

Ala Leu Gly Asp Thr Leu Thr Ile Thr Leu Gly Gly Ser Gly Gly Thr 
1               5                   10                  15      


Ala Lys Val Leu Arg Lys Ile Asn Gln Asp Gly Tyr Thr Ser Glu Tyr 
            20                  25                  30          


Tyr Leu Pro Glu Thr Ser Ser Ser Phe Arg Ala Lys Val Arg His Thr 
        35                  40                  45              


Lys Glu Ser Val Lys Pro Asn Gln Val Gln Tyr Glu Arg His Asn Val 
    50                  55                  60                  


Glu Phe Thr Glu Thr Val Tyr Ala Ser Gly Ser Thr Pro Glu Phe Val 
65                  70                  75                  80  


Arg Gln Ala Tyr Val Val Ile Arg His Lys Val Gly Asp Val Ser Ala 
                85                  90                  95      


Thr Val Ser Asp Leu Gly Glu Ala Leu Ser Phe Tyr Leu Asn Glu Ala 
            100                 105                 110         


Leu Tyr Gly Lys Leu Ile Gly Trp Glu Ser 
        115                 120         


<210>  4
<211>  369
<212>  DNA
<213>  Bacteriophage phi Cb5

<400>  4
atggctctcg gcgacactct tacgatcact cttggtggct ctggcggaac tgccaaagtc     60

ctcaagaaga tcaaccagga cggatatacc tcagagtact acctgcccga aacgagttct    120

tcgttccggg ccaaggtgcg tcacactaag gaatccgtca agccgaacca ggttcagtac    180

gaacgccaca atgtggagtt cactgaaacg gtgtatgcct ctggctctac gcccgagttc    240

gtccgccaag cttacgtcgt catccgccac aaggtgggtg acgtctctgc tactgtttcg    300

gacctcggcg aggcgctttc gttctatctg aacgaagccc tctacgggaa gctcatcggc    360

tgggaatcg                                                            369


<210>  5
<211>  123
<212>  PRT
<213>  Bacteriophage phi Cb5

<400>  5

Met Ala Leu Gly Asp Thr Leu Thr Ile Thr Leu Gly Gly Ser Gly Gly 
1               5                   10                  15      


Thr Ala Lys Val Leu Lys Lys Ile Asn Gln Asp Gly Tyr Thr Ser Glu 
            20                  25                  30          


Tyr Tyr Leu Pro Glu Thr Ser Ser Ser Phe Arg Ala Lys Val Arg His 
        35                  40                  45              


Thr Lys Glu Ser Val Lys Pro Asn Gln Val Gln Tyr Glu Arg His Asn 
    50                  55                  60                  


Val Glu Phe Thr Glu Thr Val Tyr Ala Ser Gly Ser Thr Pro Glu Phe 
65                  70                  75                  80  


Val Arg Gln Ala Tyr Val Val Ile Arg His Lys Val Gly Asp Val Ser 
                85                  90                  95      


Ala Thr Val Ser Asp Leu Gly Glu Ala Leu Ser Phe Tyr Leu Asn Glu 
            100                 105                 110         


Ala Leu Tyr Gly Lys Leu Ile Gly Trp Glu Ser 
        115                 120             


<210>  6
<211>  122
<212>  PRT
<213>  Bacteriophage phi Cb5

<400>  6

Ala Leu Gly Asp Thr Leu Thr Ile Thr Leu Gly Gly Ser Gly Gly Thr 
1               5                   10                  15      


Ala Lys Val Leu Lys Lys Ile Asn Gln Asp Gly Tyr Thr Ser Glu Tyr 
            20                  25                  30          


Tyr Leu Pro Glu Thr Ser Ser Ser Phe Arg Ala Lys Val Arg His Thr 
        35                  40                  45              


Lys Glu Ser Val Lys Pro Asn Gln Val Gln Tyr Glu Arg His Asn Val 
    50                  55                  60                  


Glu Phe Thr Glu Thr Val Tyr Ala Ser Gly Ser Thr Pro Glu Phe Val 
65                  70                  75                  80  


Arg Gln Ala Tyr Val Val Ile Arg His Lys Val Gly Asp Val Ser Ala 
                85                  90                  95      


Thr Val Ser Asp Leu Gly Glu Ala Leu Ser Phe Tyr Leu Asn Glu Ala 
            100                 105                 110         


Leu Tyr Gly Lys Leu Ile Gly Trp Glu Ser 
        115                 120         


<210>  7
<211>  122
<212>  PRT
<213>  Bacteriophage phi Cb5

<400>  7

Ala Leu Gly Asp Thr Leu Thr Ile Thr Leu Gly Gly Ser Gly Gly Thr 
1               5                   10                  15      


Ala Lys Val Leu Arg Lys Ile Asn Gln Asp Gly Tyr Thr Ser Glu Tyr 
            20                  25                  30          


Tyr Leu Pro Glu Thr Ser Ser Ser Phe Arg Ala Lys Val Arg His Thr 
        35                  40                  45              


Lys Glu Ser Val Lys Pro Asn Gln Val Gln Tyr Glu Arg His Asn Val 
    50                  55                  60                  


Glu Phe Thr Glu Thr Val Tyr Ala Ser Cys Cys Thr Pro Glu Phe Val 
65                  70                  75                  80  


Arg Gln Ala Tyr Val Val Ile Arg His Lys Val Gly Asp Val Ser Ala 
                85                  90                  95      


Thr Val Ser Asp Leu Gly Glu Ala Leu Ser Phe Tyr Leu Asn Glu Ala 
            100                 105                 110         


Leu Tyr Gly Lys Leu Ile Gly Trp Glu Ser 
        115                 120         


<210>  8
<211>  122
<212>  PRT
<213>  Bacteriophage phi Cb5

<400>  8

Ala Leu Gly Asp Thr Leu Thr Ile Thr Leu Gly Gly Ser Gly Gly Thr 
1               5                   10                  15      


Ala Lys Val Leu Lys Lys Ile Asn Gln Asp Gly Tyr Thr Ser Glu Tyr 
            20                  25                  30          


Tyr Leu Pro Glu Thr Ser Ser Ser Phe Arg Ala Lys Val Arg His Thr 
        35                  40                  45              


Lys Glu Ser Val Lys Pro Asn Gln Val Gln Tyr Glu Arg His Asn Val 
    50                  55                  60                  


Glu Phe Thr Glu Thr Val Tyr Ala Ser Cys Cys Thr Pro Glu Phe Val 
65                  70                  75                  80  


Arg Gln Ala Tyr Val Val Ile Arg His Lys Val Gly Asp Val Ser Ala 
                85                  90                  95      


Thr Val Ser Asp Leu Gly Glu Ala Leu Ser Phe Tyr Leu Asn Glu Ala 
            100                 105                 110         


Leu Tyr Gly Lys Leu Ile Gly Trp Glu Ser 
        115                 120         


<210>  9
<211>  122
<212>  PRT
<213>  Bacteriophage phi Cb5

<400>  9

Cys Leu Gly Cys Thr Leu Thr Ile Thr Leu Gly Gly Ser Gly Gly Thr 
1               5                   10                  15      


Ala Lys Val Leu Arg Lys Ile Asn Gln Asp Gly Tyr Thr Ser Glu Tyr 
            20                  25                  30          


Tyr Leu Pro Glu Thr Ser Ser Ser Phe Arg Ala Lys Val Arg His Thr 
        35                  40                  45              


Lys Glu Ser Val Lys Pro Asn Gln Val Gln Tyr Glu Arg His Asn Val 
    50                  55                  60                  


Glu Phe Thr Glu Thr Val Tyr Ala Ser Gly Ser Thr Pro Glu Phe Val 
65                  70                  75                  80  


Arg Gln Ala Tyr Val Val Ile Arg His Lys Val Gly Asp Val Ser Ala 
                85                  90                  95      


Thr Val Ser Asp Leu Gly Glu Ala Leu Ser Phe Tyr Leu Asn Glu Ala 
            100                 105                 110         


Leu Tyr Gly Lys Leu Ile Gly Trp Glu Ser 
        115                 120         


<210>  10
<211>  122
<212>  PRT
<213>  Bacteriophage phi Cb5

<400>  10

Cys Leu Gly Cys Thr Leu Thr Ile Thr Leu Gly Gly Ser Gly Gly Thr 
1               5                   10                  15      


Ala Lys Val Leu Lys Lys Ile Asn Gln Asp Gly Tyr Thr Ser Glu Tyr 
            20                  25                  30          


Tyr Leu Pro Glu Thr Ser Ser Ser Phe Arg Ala Lys Val Arg His Thr 
        35                  40                  45              


Lys Glu Ser Val Lys Pro Asn Gln Val Gln Tyr Glu Arg His Asn Val 
    50                  55                  60                  


Glu Phe Thr Glu Thr Val Tyr Ala Ser Gly Ser Thr Pro Glu Phe Val 
65                  70                  75                  80  


Arg Gln Ala Tyr Val Val Ile Arg His Lys Val Gly Asp Val Ser Ala 
                85                  90                  95      


Thr Val Ser Asp Leu Gly Glu Ala Leu Ser Phe Tyr Leu Asn Glu Ala 
            100                 105                 110         


Leu Tyr Gly Lys Leu Ile Gly Trp Glu Ser 
        115                 120         


<210>  11
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  11
tttcatatgg ctctcggcga cactc                                           25


<210>  12
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  12
ttctcgaggc ttactccaga agtaagcacc                                      30


<210>  13
<211>  38
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  13
gtaagcttgg cggacgaact cgggcgtaca gcaagagg                             38


<210>  14
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Arg Val Tyr Ile His Pro Gly Gly Cys 
1               5                   10  


<210>  15
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  15

His Cys Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe 
1               5                   10              


<210>  16
<211>  23
<212>  PRT
<213>  Mus musculus

<400>  16

Cys Gly Gly Ser Ser Gln Asn Ser Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn His Gln Val Glu 
            20              


<210>  17
<211>  148
<212>  PRT
<213>  Mus musculus

<400>  17

Met His His His His His His Gly Ser Ala Ala Ile Ile Pro Gln Ser 
1               5                   10                  15      


Ser Ala Cys Pro Asn Thr Glu Ala Lys Asp Phe Leu Gln Asn Val Lys 
            20                  25                  30          


Val Asn Leu Lys Val Phe Asn Ser Leu Gly Ala Lys Val Ser Ser Arg 
        35                  40                  45              


Arg Pro Ser Asp Tyr Leu Asn Arg Ser Thr Ser Pro Trp Thr Leu His 
    50                  55                  60                  


Arg Asn Glu Asp Pro Asp Arg Tyr Pro Ser Val Ile Trp Glu Ala Gln 
65                  70                  75                  80  


Cys Arg His Gln Arg Cys Val Asn Ala Glu Gly Lys Leu Asp His His 
                85                  90                  95      


Met Asn Ser Val Leu Ile Gln Gln Glu Ile Leu Val Leu Lys Arg Glu 
            100                 105                 110         


Pro Glu Ser Cys Pro Phe Thr Phe Arg Val Glu Lys Met Leu Val Gly 
        115                 120                 125             


Val Gly Cys Thr Cys Val Ala Ser Ile Val Arg Gln Ala Ala Gly Gly 
    130                 135                 140                 


Gly Gly Gly Cys 
145             


<210>  18
<211>  27
<212>  PRT
<213>  Influenza A virus

<400>  18

Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly Cys 
1               5                   10                  15      


Arg Cys Asn Asp Ser Ser Asp Gly Gly Gly Cys 
            20                  25          


<210>  19
<211>  10
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  19
gacgatcgtc                                                            10


<210>  20
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  20
gggggggacg atcgtcgggg gg                                              22


<210>  21
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  21
ggggggggac gatcgtcggg gggg                                            24


<210>  22
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  22
ggggggggga cgatcgtcgg gggggg                                          26


<210>  23
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  23
gggggggggg acgatcgtcg gggggggg                                        28


<210>  24
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  24
gggggggggg gacgatcgtc gggggggggg                                      30


<210>  25
<211>  24
<212>  PRT
<213>  Influenza A virus

<400>  25

Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly Cys 
1               5                   10                  15      


Arg Cys Asn Asp Ser Ser Asp Gly 
            20                  


<210>  26
<211>  5790
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  26
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc    120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg    180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc    240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt    300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc    360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta    420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt    480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta    540

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat    600

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt    660

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg    720

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga    780

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg    840

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt    900

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg    960

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg   1020

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga   1080

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc   1140

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc   1200

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc   1260

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg   1320

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac   1380

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc   1440

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt   1500

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac   1560

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa   1620

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc   1680

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt   1740

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg   1800

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc   1860

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt   1920

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga   1980

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct   2040

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg   2100

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca   2160

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa   2220

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt   2280

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga   2340

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga   2400

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg   2460

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat   2520

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct   2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct   2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct   2700

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt   2760

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg   2820

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa   2880

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc   2940

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa   3000

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta   3060

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg   3120

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag   3180

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac   3240

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca   3300

cccgtggggc cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg   3360

gaccagtgac gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc   3420

cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg   3480

gcacctgtcc tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca   3540

tgccccgcgc ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag   3600

atcccggtgc ctaatgagtg agctaactta cattaattgc gttgcgctca ctgcccgctt   3660

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag   3720

gcggtttgcg tattgggcgc cagggtggtt tttcttttca ccagtgagac gggcaacagc   3780

tgattgccct tcaccgcctg gccctgagag agttgcagca agcggtccac gctggtttgc   3840

cccagcaggc gaaaatcctg tttgatggtg gttaacggcg ggatataaca tgagctgtct   3900

tcggtatcgt cgtatcccac taccgagata tccgcaccaa cgcgcagccc ggactcggta   3960

atggcgcgca ttgcgcccag cgccatctga tcgttggcaa ccagcatcgc agtgggaacg   4020

atgccctcat tcagcatttg catggtttgt tgaaaaccgg acatggcact ccagtcgcct   4080

tcccgttccg ctatcggctg aatttgattg cgagtgagat atttatgcca gccagccaga   4140

cgcagacgcg ccgagacaga acttaatggg cccgctaaca gcgcgatttg ctggtgaccc   4200

aatgcgacca gatgctccac gcccagtcgc gtaccgtctt catgggagaa aataatactg   4260

ttgatgggtg tctggtcaga gacatcaaga aataacgccg gaacattagt gcaggcagct   4320

tccacagcaa tggcatcctg gtcatccagc ggatagttaa tgatcagccc actgacgcgt   4380

tgcgcgagaa gattgtgcac cgccgcttta caggcttcga cgccgcttcg ttctaccatc   4440

gacaccacca cgctggcacc cagttgatcg gcgcgagatt taatcgccgc gacaatttgc   4500

gacggcgcgt gcagggccag actggaggtg gcaacgccaa tcagcaacga ctgtttgccc   4560

gccagttgtt gtgccacgcg gttgggaatg taattcagct ccgccatcgc cgcttccact   4620

ttttcccgcg ttttcgcaga aacgtggctg gcctggttca ccacgcggga aacggtctga   4680

taagagacac cggcatactc tgcgacatcg tataacgtta ctggtttcac attcaccacc   4740

ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt gcgccattcg   4800

atggtgtccg ggatctcgac gctctccctt atgcgactcc tgcattagga agcagcccag   4860

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc   4920

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat   4980

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc   5040

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatcgagat   5100

ctcgatcccg cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc   5160

cctctagaaa taattttgtt taactttaag aaggagatat acatatggct ctcggcgaca   5220

ctcttacgat cactcttggt ggctctggcg gaactgccaa agtcctcagg aagatcaacc   5280

aggacggata tacctcagag tactacctgc ccgaaacgag ttcttcgttc cgggccaagg   5340

tgcgtcacac taaggaatcc gtcaagccga accaggttca gtacgaacgc cacaatgtgg   5400

agttcactga aacggtgtat gcctctggct ctacgcccga gttcgtccgc caagcttacg   5460

tcgtcatccg ccacaaggtg ggtgacgtct ctgctactgt ttcggacctc ggcgaggcgc   5520

tttcgttcta tctgaacgaa gccctctacg ggaagctcat cggctgggaa tcgtgaaggt   5580

aatcttcgcg gttctccggc ttttgggtgc ttacttctgg agtaagcctc gagcaccacc   5640

accaccacca ctgagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg   5700

ccaccgctga gcaataacta gcataacccc ttggggcctc taaacgggtc ttgaggggtt   5760

ttttgctgaa aggaggaact atatccggat                                    5790


<210>  27
<211>  5790
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  27
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc    120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg    180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc    240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt    300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc    360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta    420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt    480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta    540

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat    600

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt    660

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg    720

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga    780

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg    840

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt    900

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg    960

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg   1020

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga   1080

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc   1140

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc   1200

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc   1260

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg   1320

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac   1380

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc   1440

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt   1500

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac   1560

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa   1620

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc   1680

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt   1740

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg   1800

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc   1860

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt   1920

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga   1980

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct   2040

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg   2100

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca   2160

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa   2220

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt   2280

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga   2340

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga   2400

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg   2460

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat   2520

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct   2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct   2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct   2700

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt   2760

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg   2820

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa   2880

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc   2940

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa   3000

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta   3060

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg   3120

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag   3180

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac   3240

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca   3300

cccgtggggc cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg   3360

gaccagtgac gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc   3420

cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg   3480

gcacctgtcc tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca   3540

tgccccgcgc ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag   3600

atcccggtgc ctaatgagtg agctaactta cattaattgc gttgcgctca ctgcccgctt   3660

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag   3720

gcggtttgcg tattgggcgc cagggtggtt tttcttttca ccagtgagac gggcaacagc   3780

tgattgccct tcaccgcctg gccctgagag agttgcagca agcggtccac gctggtttgc   3840

cccagcaggc gaaaatcctg tttgatggtg gttaacggcg ggatataaca tgagctgtct   3900

tcggtatcgt cgtatcccac taccgagata tccgcaccaa cgcgcagccc ggactcggta   3960

atggcgcgca ttgcgcccag cgccatctga tcgttggcaa ccagcatcgc agtgggaacg   4020

atgccctcat tcagcatttg catggtttgt tgaaaaccgg acatggcact ccagtcgcct   4080

tcccgttccg ctatcggctg aatttgattg cgagtgagat atttatgcca gccagccaga   4140

cgcagacgcg ccgagacaga acttaatggg cccgctaaca gcgcgatttg ctggtgaccc   4200

aatgcgacca gatgctccac gcccagtcgc gtaccgtctt catgggagaa aataatactg   4260

ttgatgggtg tctggtcaga gacatcaaga aataacgccg gaacattagt gcaggcagct   4320

tccacagcaa tggcatcctg gtcatccagc ggatagttaa tgatcagccc actgacgcgt   4380

tgcgcgagaa gattgtgcac cgccgcttta caggcttcga cgccgcttcg ttctaccatc   4440

gacaccacca cgctggcacc cagttgatcg gcgcgagatt taatcgccgc gacaatttgc   4500

gacggcgcgt gcagggccag actggaggtg gcaacgccaa tcagcaacga ctgtttgccc   4560

gccagttgtt gtgccacgcg gttgggaatg taattcagct ccgccatcgc cgcttccact   4620

ttttcccgcg ttttcgcaga aacgtggctg gcctggttca ccacgcggga aacggtctga   4680

taagagacac cggcatactc tgcgacatcg tataacgtta ctggtttcac attcaccacc   4740

ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt gcgccattcg   4800

atggtgtccg ggatctcgac gctctccctt atgcgactcc tgcattagga agcagcccag   4860

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc   4920

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat   4980

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc   5040

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatcgagat   5100

ctcgatcccg cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc   5160

cctctagaaa taattttgtt taactttaag aaggagatat acatatggct ctcggcgaca   5220

ctcttacgat cactcttggt ggctctggcg gaactgccaa agtcctcaag aagatcaacc   5280

aggacggata tacctcagag tactacctgc ccgaaacgag ttcttcgttc cgggccaagg   5340

tgcgtcacac taaggaatcc gtcaagccga accaggttca gtacgaacgc cacaatgtgg   5400

agttcactga aacggtgtat gcctctggct ctacgcccga gttcgtccgc caagcttacg   5460

tcgtcatccg ccacaaggtg ggtgacgtct ctgctactgt ttcggacctc ggcgaggcgc   5520

tttcgttcta tctgaacgaa gccctctacg ggaagctcat cggctgggaa tcgtgaaggt   5580

aatcttcgcg gttctccggc ttttgggtgc ttacttctgg agtaagcctc gagcaccacc   5640

accaccacca ctgagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg   5700

ccaccgctga gcaataacta gcataacccc ttggggcctc taaacgggtc ttgaggggtt   5760

ttttgctgaa aggaggaact atatccggat                                    5790


<210>  28
<211>  5790
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthetized

<400>  28
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc    120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg    180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc    240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt    300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc    360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta    420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt    480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta    540

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat    600

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt    660

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg    720

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga    780

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg    840

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt    900

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg    960

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg   1020

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga   1080

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc   1140

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc   1200

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc   1260

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg   1320

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac   1380

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc   1440

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt   1500

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac   1560

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa   1620

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc   1680

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt   1740

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg   1800

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc   1860

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt   1920

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga   1980

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct   2040

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg   2100

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca   2160

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa   2220

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt   2280

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga   2340

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga   2400

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg   2460

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat   2520

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct   2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct   2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct   2700

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt   2760

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg   2820

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa   2880

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc   2940

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa   3000

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta   3060

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg   3120

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag   3180

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac   3240

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca   3300

cccgtggggc cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg   3360

gaccagtgac gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc   3420

cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg   3480

gcacctgtcc tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca   3540

tgccccgcgc ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag   3600

atcccggtgc ctaatgagtg agctaactta cattaattgc gttgcgctca ctgcccgctt   3660

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag   3720

gcggtttgcg tattgggcgc cagggtggtt tttcttttca ccagtgagac gggcaacagc   3780

tgattgccct tcaccgcctg gccctgagag agttgcagca agcggtccac gctggtttgc   3840

cccagcaggc gaaaatcctg tttgatggtg gttaacggcg ggatataaca tgagctgtct   3900

tcggtatcgt cgtatcccac taccgagata tccgcaccaa cgcgcagccc ggactcggta   3960

atggcgcgca ttgcgcccag cgccatctga tcgttggcaa ccagcatcgc agtgggaacg   4020

atgccctcat tcagcatttg catggtttgt tgaaaaccgg acatggcact ccagtcgcct   4080

tcccgttccg ctatcggctg aatttgattg cgagtgagat atttatgcca gccagccaga   4140

cgcagacgcg ccgagacaga acttaatggg cccgctaaca gcgcgatttg ctggtgaccc   4200

aatgcgacca gatgctccac gcccagtcgc gtaccgtctt catgggagaa aataatactg   4260

ttgatgggtg tctggtcaga gacatcaaga aataacgccg gaacattagt gcaggcagct   4320

tccacagcaa tggcatcctg gtcatccagc ggatagttaa tgatcagccc actgacgcgt   4380

tgcgcgagaa gattgtgcac cgccgcttta caggcttcga cgccgcttcg ttctaccatc   4440

gacaccacca cgctggcacc cagttgatcg gcgcgagatt taatcgccgc gacaatttgc   4500

gacggcgcgt gcagggccag actggaggtg gcaacgccaa tcagcaacga ctgtttgccc   4560

gccagttgtt gtgccacgcg gttgggaatg taattcagct ccgccatcgc cgcttccact   4620

ttttcccgcg ttttcgcaga aacgtggctg gcctggttca ccacgcggga aacggtctga   4680

taagagacac cggcatactc tgcgacatcg tataacgtta ctggtttcac attcaccacc   4740

ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt gcgccattcg   4800

atggtgtccg ggatctcgac gctctccctt atgcgactcc tgcattagga agcagcccag   4860

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc   4920

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat   4980

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc   5040

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatcgagat   5100

ctcgatcccg cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc   5160

cctctagaaa taattttgtt taactttaag aaggagatat acatatggct ctcggcgaca   5220

ctcttacgat cactcttggt ggctctggcg gaactgccaa agtcctcaag aagatcaacc   5280

aggacggata tacctcagag tactacctgc ccgaaacgag ttcttcgttc cgggccaagg   5340

tgcgtcacac taaggaatcc gtcaagccga accaggttca gtacgaacgc cacaatgtgg   5400

agttcactga aacggtgtat gcctcttgct gtacgcccga gttcgtccgc caagcttacg   5460

tcgtcatccg ccacaaggtg ggtgacgtct ctgctactgt ttcggacctc ggcgaggcgc   5520

tttcgttcta tctgaacgaa gccctctacg ggaagctcat cggctgggaa tcgtgaaggt   5580

aatcttcgcg gttctccggc ttttgggtgc ttacttctgg agtaagcctc gagcaccacc   5640

accaccacca ctgagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg   5700

ccaccgctga gcaataacta gcataacccc ttggggcctc taaacgggtc ttgaggggtt   5760

ttttgctgaa aggaggaact atatccggat                                    5790


<210>  29
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  29
gctacgaatt ccgactgcga g                                               21


<210>  30
<211>  16
<212>  PRT
<213>  Influenza A virus

<400>  30

Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly Cys 
1               5                   10                  15      


