                         SEQUENCE LISTING

<110>  Boehringer Ingelheim International GmbH
 
<120>  An improved antibody domain and antibody fragments and antibodies
        based thereon

<130>  P01-2578/WO/1

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  99
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  murine IgA

<400>  1

Glu Ser Ala Arg Asn Pro Thr Ile Tyr Pro Leu Thr Leu Pro Pro Ala 
1               5                   10                  15      


Leu Ser Ser Asp Pro Val Ile Ile Gly Cys Leu Ile His Asp Tyr Phe 
            20                  25                  30          


Pro Ser Gly Thr Met Asn Val Thr Trp Gly Lys Ser Gly Lys Asp Ile 
        35                  40                  45              


Thr Thr Val Asn Phe Pro Pro Ala Leu Ala Ser Gly Gly Arg Tyr Thr 
    50                  55                  60                  


Met Ser Ser Gln Leu Thr Leu Pro Ala Val Glu Cys Pro Glu Gly Glu 
65                  70                  75                  80  


Ser Val Lys Cys Ser Val Gln His Asp Ser Asn Pro Val Gln Glu Leu 
                85                  90                  95      


Asp Val Asn 
            


<210>  2
<211>  126
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  murine IgD

<400>  2

Asp Lys Lys Glu Pro Asp Met Phe Leu Leu Ser Glu Cys Lys Ala Pro 
1               5                   10                  15      


Glu Glu Asn Glu Lys Ile Asn Leu Gly Cys Leu Cys Ile Gly Ser Gln 
            20                  25                  30          


Pro Leu Lys Ile Ser Trp Glu Pro Lys Lys Ser Ser Ile Val Glu His 
        35                  40                  45              


Val Phe Pro Ser Glu Met Arg Asn Gly Asn Tyr Thr Met Val Leu Gln 
    50                  55                  60                  


Val Thr Val Leu Ala Ser Glu Leu Asn Leu Asn His Thr Cys Thr Ile 
65                  70                  75                  80  


Asn Lys Pro Lys Arg Lys Glu Lys Pro Phe Lys Phe Pro Gly Ser Trp 
                85                  90                  95      


Asp Ser Gln Ser Ser Lys Arg Val Thr Pro Thr Leu Gln Ala Lys Asn 
            100                 105                 110         


His Ser Thr Glu Ala Thr Lys Ala Ile Thr Thr Lys Lys Asp 
        115                 120                 125     


<210>  3
<211>  106
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  murine IgE

<400>  3

Ser Ile Arg Asn Pro Gln Leu Tyr Pro Leu Lys Pro Cys Lys Gly Thr 
1               5                   10                  15      


Ala Ser Met Thr Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Asn Pro 
            20                  25                  30          


Val Thr Val Thr Trp Tyr Ser Asp Ser Leu Asn Met Ser Thr Val Asn 
        35                  40                  45              


Phe Pro Ala Leu Gly Ser Glu Leu Lys Val Thr Thr Ser Gln Val Thr 
    50                  55                  60                  


Ser Trp Gly Lys Ser Ala Lys Asn Phe Thr Cys His Val Thr His Pro 
65                  70                  75                  80  


Pro Ser Phe Asn Glu Ser Arg Thr Ile Leu Val Arg Pro Val Asn Ile 
                85                  90                  95      


Thr Glu Pro Thr Leu Glu Leu Leu His Ser 
            100                 105     


<210>  4
<211>  101
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  murine IgG1

<220>
<221>  MISC_FEATURE
<223>  murine IgG1 from MAK33 antibody

<400>  4

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp 
            100     


<210>  5
<211>  105
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  murine IgG2a

<400>  5

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Glu Pro Arg Gly Pro Thr Ile Lys 
            100                 105 


<210>  6
<211>  106
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  murine IgG2b

<400>  6

Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp 
1               5                   10                  15      


Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
            20                  25                  30          


Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser 
        35                  40                  45              


Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser 
    50                  55                  60                  


Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr 
65                  70                  75                  80  


Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val Asp Lys Lys Leu 
                85                  90                  95      


Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn 
            100                 105     


<210>  7
<211>  109
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  murine IgG3

<400>  7

Thr Thr Thr Ala Pro Ser Val Tyr Pro Leu Val Pro Gly Cys Ser Asp 
1               5                   10                  15      


Thr Ser Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Lys Trp Asn Tyr Gly Ala Leu Ser Ser Gly 
        35                  40                  45              


Val Arg Thr Val Ser Ser Val Leu Gln Ser Gly Phe Tyr Ser Leu Ser 
    50                  55                  60                  


Ser Leu Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Ile 
65                  70                  75                  80  


Cys Asn Val Ala His Pro Ala Ser Lys Thr Glu Leu Ile Lys Arg Ile 
                85                  90                  95      


Glu Pro Arg Ile Pro Lys Pro Ser Thr Pro Pro Gly Ser 
            100                 105                 


<210>  8
<211>  108
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  murine IgM

<400>  8

Ser Gln Ser Phe Pro Asn Val Phe Pro Leu Val Ser Cys Glu Ser Pro 
1               5                   10                  15      


Leu Ser Asp Lys Asn Leu Val Ala Met Gly Cys Leu Ala Arg Asp Phe 
            20                  25                  30          


Leu Pro Ser Thr Ile Ser Phe Thr Trp Asn Tyr Gln Asn Asn Thr Glu 
        35                  40                  45              


Val Ile Gln Gly Ile Arg Thr Phe Pro Thr Leu Arg Thr Gly Gly Lys 
    50                  55                  60                  


Tyr Leu Ala Thr Ser Gln Val Leu Leu Ser Pro Lys Ser Ile Leu Glu 
65                  70                  75                  80  


Gly Ser Asp Glu Tyr Leu Val Cys Lys Ile His Tyr Gly Gly Lys Asn 
                85                  90                  95      


Lys Asp Leu His Val Pro Ile Pro Ala Val Ala Glu 
            100                 105             


<210>  9
<211>  100
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human IgA1

<400>  9

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro 
            100 


<210>  10
<211>  100
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human IgA2

<400>  10

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro 
            100 


<210>  11
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human IgD

<400>  11

Ala Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg 
1               5                   10                  15      


His Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly 
            20                  25                  30          


Tyr His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser 
        35                  40                  45              


Gln Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr 
    50                  55                  60                  


Met Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly 
65                  70                  75                  80  


Glu Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu 
                85                  90                  95      


Ile Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser 
            100                 105                 110 


<210>  12
<211>  103
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human IgE

<400>  12

Ala Ser Thr Gln Ser Pro Ser Val Phe Pro Leu Thr Arg Cys Cys Lys 
1               5                   10                  15      


Asn Ile Pro Ser Asn Ala Thr Ser Val Thr Leu Gly Cys Leu Ala Thr 
            20                  25                  30          


Gly Tyr Phe Pro Glu Pro Val Met Val Thr Trp Asp Thr Gly Ser Leu 
        35                  40                  45              


Asn Gly Thr Thr Met Thr Leu Pro Ala Thr Thr Leu Thr Leu Ser Gly 
    50                  55                  60                  


His Tyr Ala Thr Ile Ser Leu Leu Thr Val Ser Gly Ala Trp Ala Lys 
65                  70                  75                  80  


Gln Met Phe Thr Cys Arg Val Ala His Thr Pro Ser Ser Thr Asp Trp 
                85                  90                  95      


Val Asp Asn Lys Thr Phe Ser 
            100             


<210>  13
<211>  102
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human IgG1

<400>  13

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser 
            100         


<210>  14
<211>  101
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human IgG2

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys 
            100     


<210>  15
<211>  102
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human IgG3

<400>  15

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr 
            100         


<210>  16
<211>  101
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human IgG4

<400>  16

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys 
            100     


<210>  17
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human IgM

<400>  17

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro 
            100                 105                 110 


<210>  18
<211>  101
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  murine IgG1 as depicted in SwissProt-identifier IGHG1_MOUSE

<400>  18

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Pro Arg Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp 
            100     


