
                                SEQUENCE LISTING

<110> GLAXO GROUP LIMITED
      BEATON, Andrew
      CLEVELAND, Sean Matthew
      GOUGH, Gerald Wayne
      PAULIK, Mark Andrew
      

<120> FGFR1c antibody combinations
  

<130> PB63637

<150> US61/172386         
<151> 2009-04-24  

<160> 37

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1335
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence
      

<400> 1
caggtgcagc tggtgcagag cggcgctgag gtgaagaagc ccggctcctc cgtcaaggtc 60
agctgcaagg cgagcgggca gacattcacc ggatactaca tgcattgggt gcgccaggcc 120
ccggggcagg ggctcgagtg gatggggaga atcatcccca tcctgggcat cgctcagaag 180
ttccagggac gcgtgaccat caccgccgac aaatccacca gcaccgccta catggaactg 240
agctccctgc gctccgagga caccgccgtg tattattgcg cccgcggggg cgacctgggc 300
ggcatggacg tgtggggcca gggcacacta gtcaccgtct cctcagccaa aacaacagcc 360
ccatcggtct atccactggc ccctgtgtgt ggagatacaa ctggctcctc ggtgactcta 420
ggatgcctgg tcaagggtta tttccctgag ccagtgacct tgacctggaa ctctggatcc 480
ctgtccagtg gtgtgcacac cttcccagct gtcctgcagt ctgacctcta caccctcagc 540
agctcagtga ctgtaacctc gagcacctgg cccagccagt ccatcacctg caatgtggcc 600
cacccggcaa gcagcaccaa ggtggacaag aaaattgagc ccagagggcc cacaatcaag 660
ccctgtcctc catgcaaatg cccagcacct aacctcgcgg gtgcaccatc cgtcttcatc 720
ttccctccaa agatcaagga tgtactcatg atctccctga gccccatagt cacatgtgtg 780
gtggtggatg tgagcgagga tgacccagat gtccagatca gctggtttgt gaacaacgtg 840
gaagtacaca cagctcagac acaaacccat agagaggatt acaacagtac tctccgggtg 900
gtcagtgccc tccccatcca gcaccaggac tggatgagtg gcaaggagtt caaatgcaag 960
gtcaacaaca aagacctccc agcgcccatc gagagaacca tctcaaaacc caaagggtca 1020
gtaagagctc cacaggtata tgtcttgcct ccaccagaag aagagatgac taagaaacag 1080
gtcactctga cctgcatggt cacagacttc atgcctgaag acatttacgt ggagtggacc 1140
aacaacggga aaacagagct aaactacaag aacactgaac cagtcctgga ctctgatggt 1200
tcttacttca tgtacagcaa gctgagagtg gaaaagaaga actgggtgga aagaaatagc 1260
tactcctgtt cagtggtcca cgagggtctg cacaatcacc acacgactaa gagcttctcc 1320
cggactccgg gtaaa                                                  1335

<210> 2
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 2
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gln Thr Phe Thr Gly Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Gln Lys Phe Gln Gly Arg
    50                  55                  60                  
Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu
65                  70                  75                  80  
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly
                85                  90                  95      
Gly Asp Leu Gly Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro
        115                 120                 125             
Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser
145                 150                 155                 160 
Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu
                165                 170                 175     
Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser
            180                 185                 190         
Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val
        195                 200                 205             
Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro
    210                 215                 220                 
Cys Lys Cys Pro Ala Pro Asn Leu Ala Gly Ala Pro Ser Val Phe Ile
225                 230                 235                 240 
Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln
            260                 265                 270         
Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln
        275                 280                 285             
Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu
    290                 295                 300                 
Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys
305                 310                 315                 320 
Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys
                325                 330                 335     
Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro
            340                 345                 350         
Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr
        355                 360                 365             
Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys
    370                 375                 380                 
Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val
                405                 410                 415     
Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn
            420                 425                 430         
His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
        435                 440                 445 


<210> 3
<211> 657
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 3
Gly Ala Gly Ala Thr Cys Gly Thr Gly Cys Thr Gly Ala Cys Cys Cys
 1               5                  10                  15      
Ala Gly Ala Gly Cys Cys Cys Cys Cys Thr Cys Thr Cys Gly Cys Thr
            20                  25                  30          
Gly Cys Cys Cys Gly Thr Gly Ala Cys Cys Cys Cys Cys Gly Gly Gly
        35                  40                  45              
Gly Ala Gly Cys Cys Cys Gly Cys Cys Ala Gly Cys Ala Thr Cys Thr
    50                  55                  60                  
Cys Cys Thr Gly Cys Cys Gly Cys Ala Gly Thr Ala Gly Cys Cys Ala
65                  70                  75                  80  
Gly Ala Gly Cys Cys Thr Gly Ala Gly Gly Cys Ala Thr Thr Cys Cys
                85                  90                  95      
Ala Ala Thr Gly Gly Cys Thr Ala Cys Ala Ala Cys Thr Ala Cys Cys
            100                 105                 110         
Thr Gly Gly Ala Cys Thr Gly Gly Thr Ala Cys Cys Thr Gly Cys Ala
        115                 120                 125             
Gly Ala Ala Ala Cys Cys Cys Gly Gly Cys Cys Ala Gly Ala Gly Cys
    130                 135                 140                 
Cys Cys Cys Cys Ala Gly Cys Thr Gly Cys Thr Cys Ala Thr Cys Thr
145                 150                 155                 160 
Ala Cys Cys Thr Gly Gly Cys Gly Ala Gly Thr Ala Ala Cys Cys Gly
                165                 170                 175     
Cys Gly Cys Cys Ala Gly Cys Gly Gly Gly Gly Thr Gly Cys Cys Cys
            180                 185                 190         
Gly Ala Cys Cys Gly Cys Thr Thr Cys Ala Gly Cys Gly Gly Cys Thr
        195                 200                 205             
Cys Cys Gly Gly Cys Ala Gly Thr Gly Gly Ala Ala Cys Cys Gly Ala
    210                 215                 220                 
Cys Thr Thr Cys Ala Cys Cys Cys Thr Gly Ala Ala Gly Ala Thr Cys
225                 230                 235                 240 
Thr Cys Cys Cys Gly Cys Gly Thr Gly Gly Ala Gly Gly Cys Gly Gly
                245                 250                 255     
Ala Gly Gly Ala Cys Gly Thr Gly Gly Gly Gly Gly Thr Gly Thr Ala
            260                 265                 270         
Thr Thr Ala Cys Thr Gly Thr Ala Thr Gly Cys Ala Gly Gly Cys Cys
        275                 280                 285             
Cys Thr Cys Cys Ala Gly Ala Thr Cys Cys Cys Cys Cys Cys Cys Ala
    290                 295                 300                 
Cys Gly Thr Thr Cys Gly Gly Cys Cys Cys Cys Gly Gly Cys Ala Cys
305                 310                 315                 320 
Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Thr Cys Ala Ala Ala
                325                 330                 335     
Cys Gly Cys Ala Cys Cys Gly Thr Cys Gly Cys Cys Gly Cys Cys Cys
            340                 345                 350         
Cys Gly Ala Cys Cys Gly Thr Gly Ala Gly Cys Ala Thr Thr Thr Thr
        355                 360                 365             
Cys Cys Cys Thr Cys Cys Cys Ala Gly Cys Thr Cys Cys Gly Ala Gly
    370                 375                 380                 
Cys Ala Gly Cys Thr Gly Ala Cys Gly Thr Cys Cys Gly Gly Cys Gly
385                 390                 395                 400 
Gly Cys Gly Cys Cys Thr Cys Thr Gly Thr Gly Gly Thr Gly Thr Gly
                405                 410                 415     
Cys Thr Thr Cys Cys Thr Cys Ala Ala Cys Ala Ala Cys Thr Thr Cys
            420                 425                 430         
Thr Ala Cys Cys Cys Cys Ala Ala Gly Gly Ala Cys Ala Thr Cys Ala
        435                 440                 445             
Ala Cys Gly Thr Gly Ala Ala Gly Thr Gly Gly Ala Ala Gly Ala Thr
    450                 455                 460                 
Cys Gly Ala Cys Gly Gly Cys Thr Cys Cys Gly Ala Gly Ala Gly Ala
465                 470                 475                 480 
Cys Ala Gly Ala Ala Cys Gly Gly Cys Gly Thr Gly Cys Thr Gly Ala
                485                 490                 495     
Ala Cys Ala Gly Cys Thr Gly Gly Ala Cys Cys Gly Ala Cys Cys Ala
            500                 505                 510         
Gly Gly Ala Cys Ala Gly Cys Ala Ala Gly Gly Ala Cys Thr Cys Cys
        515                 520                 525             
Ala Cys Cys Thr Ala Cys Ala Gly Thr Ala Thr Gly Ala Gly Cys Thr
    530                 535                 540                 
Cys Cys Ala Cys Cys Cys Thr Gly Ala Cys Cys Cys Thr Gly Ala Cys
545                 550                 555                 560 
Cys Ala Ala Gly Gly Ala Cys Gly Ala Gly Thr Ala Cys Gly Ala Gly
                565                 570                 575     
Ala Gly Gly Cys Ala Thr Ala Ala Cys Thr Cys Thr Thr Ala Thr Ala
            580                 585                 590         
Cys Cys Thr Gly Cys Gly Ala Gly Gly Cys Gly Ala Cys Cys Cys Ala
        595                 600                 605             
Thr Ala Ala Gly Ala Cys Cys Ala Gly Cys Ala Cys Cys Thr Cys Cys
    610                 615                 620                 
Cys Cys Cys Ala Thr Cys Gly Thr Cys Ala Ala Gly Ala Gly Cys Thr
625                 630                 635                 640 
Thr Cys Ala Ala Cys Cys Gly Cys Ala Ala Cys Gly Ala Ala Thr Gly
                645                 650                 655     
Cys
    


<210> 4
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 4
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
 1               5                  10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Arg His Ser
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Ala Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
                85                  90                  95      
Leu Gln Ile Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
            100                 105                 110         
Arg Thr Val Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu
        115                 120                 125             
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe
    130                 135                 140                 
Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg
145                 150                 155                 160 
Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser
                165                 170                 175     
Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu
            180                 185                 190         
Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser
        195                 200                 205             
Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
    210                 215                 


<210> 5
<211> 1353
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 5
caggtccaat tagtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt 60
tcctgcaagg cctctggata caccttcact aactatggaa tgaactgggt gcgacaggcc 120
cctggacaag ggctcgagtg gatgggatgg ataaacacca gaaatggaaa gtcaacatat 180
gttgatgact tcaaggggcg gtttgtcttc tccttggaca cctctgtcag cacggcatat 240
ctacagatca gcagcctaaa ggctgacgac actgcagtgt attactgtgc gagagaaggg 300
aatatggatg gttacttccc ttttacttac tggggccagg gtacactagt caccgtctcc 360
tcagccaaaa caacagcccc atcggtctat ccactggccc ctgtgtgtgg agatacaact 420
ggctcctcgg tgactctagg atgcctggtc aagggttatt tccctgagcc agtgaccttg 480
acctggaact ctggatccct gtccagtggt gtgcacacct tcccagctgt cctgcagtct 540
gacctctaca ccctcagcag ctcagtgact gtaacctcga gcacctggcc cagccagtcc 600
atcacctgca atgtggccca cccggcaagc agcaccaagg tggacaagaa aattgagccc 660
agagggccca caatcaagcc ctgtcctcca tgcaaatgcc cagcacctaa cctcgcgggt 720
gcaccatccg tcttcatctt ccctccaaag atcaaggatg tactcatgat ctccctgagc 780
cccatagtca catgtgtggt ggtggatgtg agcgaggatg acccagatgt ccagatcagc 840
tggtttgtga acaacgtgga agtacacaca gctcagacac aaacccatag agaggattac 900
aacagtactc tccgggtggt cagtgccctc cccatccagc accaggactg gatgagtggc 960
aaggagttca aatgcaaggt caacaacaaa gacctcccag cgcccatcga gagaaccatc 1020
tcaaaaccca aagggtcagt aagagctcca caggtatatg tcttgcctcc accagaagaa 1080
gagatgacta agaaacaggt cactctgacc tgcatggtca cagacttcat gcctgaagac 1140
atttacgtgg agtggaccaa caacgggaaa acagagctaa actacaagaa cactgaacca 1200
gtcctggact ctgatggttc ttacttcatg tacagcaagc tgagagtgga aaagaagaac 1260
tgggtggaaa gaaatagcta ctcctgttca gtggtccacg agggtctgca caatcaccac 1320
acgactaaga gcttctcccg gactccgggt aaa                              1353

<210> 6
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 6
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Arg Asn Gly Lys Ser Thr Tyr Val Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Ser Ser Leu Lys Ala Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Asn Met Asp Gly Tyr Phe Pro Phe Thr Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser
        115                 120                 125             
Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val
    130                 135                 140                 
Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu
145                 150                 155                 160 
Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr
            180                 185                 190         
Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro
        195                 200                 205             
Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr
    210                 215                 220                 
Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Ala Gly
225                 230                 235                 240 
Ala Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met
                245                 250                 255     
Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu
            260                 265                 270         
Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val
        275                 280                 285             
His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu
    290                 295                 300                 
Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly
305                 310                 315                 320 
Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile
                325                 330                 335     
Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val
            340                 345                 350         
Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr
        355                 360                 365             
Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu
    370                 375                 380                 
Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val
                405                 410                 415     
Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val
            420                 425                 430         
His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr
        435                 440                 445             
Pro Gly Lys
    450     


<210> 7
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 7
gatattgtca tgactcagtc tccatcatcc ctgtccgcat cagtaggaga cagggtcacc 60
atcacctgca aggcttctca gaatgtgggt actaatgtag cctggtatca acagaaacca 120
gggaaagctc ctaaagcact gatttactcg gcatcctatc ggtacagtgg agtccctgat 180
cgcttctcag gcagtggatc cgggacagat ttcactctca ccatcagcag tctgcagcct 240
gaagacttcg caacgtatta ctgtcagcaa tataacagct atcctctcac gttcggtggt 300
ggtaccaagg tggaaataaa acgtacggat gctgcaccga ctgtatccat cttcccacca 360
tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac 420
cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg 480
aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg 540
ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca 600
tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                    642

<210> 8
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 8
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Asp Ala Ala
            100                 105                 110         
Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly
        115                 120                 125             
Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile
    130                 135                 140                 
Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu
145                 150                 155                 160 
Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr
            180                 185                 190         
Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser
        195                 200                 205             
Phe Asn Arg Asn Glu Cys
    210                 


<210> 9
<211> 40
<212> PRT
<213> Heloderma horridum

<400> 9
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser Gly
        35                  40  


<210> 10
<211> 30
<212> PRT
<213> Homo Sapiens

<400> 10
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg
            20                  25                  30  


<210> 11
<211> 1494
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody-Exendin fusion

<400> 11
catggggagg gcactttcac tagcgacctg agcaagcaga tggaagaaga ggccgtgagg 60
ctgttcattg agtggctcaa gaacggaggc ccctcctccg gcgccccccc ccctagcggc 120
ggatccggag gcgggggcag tggcggggga ggtagcggtc aggtgcagct ggtgcagagc 180
ggcgctgagg tgaagaagcc cggctcctcc gtcaaggtca gctgcaaggc gagcgggcag 240
acattcaccg gatactacat gcattgggtg cgccaggccc cggggcaggg gctcgagtgg 300
atggggagaa tcatccccat cctgggcatc gctcagaagt tccagggacg cgtgaccatc 360
accgccgaca aatccaccag caccgcctac atggaactga gctccctgcg ctccgaggac 420
accgccgtgt attattgcgc ccgcgggggc gacctgggcg gcatggacgt gtggggccag 480
ggcacactag tcaccgtctc ctcagccaaa acaacagccc catcggtcta tccactggcc 540
cctgtgtgtg gagatacaac tggctcctcg gtgactctag gatgcctggt caagggttat 600
ttccctgagc cagtgacctt gacctggaac tctggatccc tgtccagtgg tgtgcacacc 660
ttcccagctg tcctgcagtc tgacctctac accctcagca gctcagtgac tgtaacctcg 720
agcacctggc ccagccagtc catcacctgc aatgtggccc acccggcaag cagcaccaag 780
gtggacaaga aaattgagcc cagagggccc acaatcaagc cctgtcctcc atgcaaatgc 840
ccagcaccta acctcgcggg tgcaccatcc gtcttcatct tccctccaaa gatcaaggat 900
gtactcatga tctccctgag ccccatagtc acatgtgtgg tggtggatgt gagcgaggat 960
gacccagatg tccagatcag ctggtttgtg aacaacgtgg aagtacacac agctcagaca 1020
caaacccata gagaggatta caacagtact ctccgggtgg tcagtgccct ccccatccag 1080
caccaggact ggatgagtgg caaggagttc aaatgcaagg tcaacaacaa agacctccca 1140
gcgcccatcg agagaaccat ctcaaaaccc aaagggtcag taagagctcc acaggtatat 1200
gtcttgcctc caccagaaga agagatgact aagaaacagg tcactctgac ctgcatggtc 1260
acagacttca tgcctgaaga catttacgtg gagtggacca acaacgggaa aacagagcta 1320
aactacaaga acactgaacc agtcctggac tctgatggtt cttacttcat gtacagcaag 1380
ctgagagtgg aaaagaagaa ctgggtggaa agaaatagct actcctgttc agtggtccac 1440
gagggtctgc acaatcacca cacgactaag agcttctccc ggactccggg taaa       1494

<210> 12
<211> 498
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody-Exendin fusion

<400> 12
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly
        35                  40                  45              
Gly Gly Gly Ser Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
    50                  55                  60                  
Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gln
65                  70                  75                  80  
Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln
                85                  90                  95      
Gly Leu Glu Trp Met Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Gln
            100                 105                 110         
Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr
        115                 120                 125             
Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr
    130                 135                 140                 
Tyr Cys Ala Arg Gly Gly Asp Leu Gly Gly Met Asp Val Trp Gly Gln
145                 150                 155                 160 
Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val
                165                 170                 175     
Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr
            180                 185                 190         
Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr
        195                 200                 205             
Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val
    210                 215                 220                 
Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser
225                 230                 235                 240 
Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala
                245                 250                 255     
Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile
            260                 265                 270         
Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Ala Gly Ala
        275                 280                 285             
Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile
    290                 295                 300                 
Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp
305                 310                 315                 320 
Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His
                325                 330                 335     
Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg
            340                 345                 350         
Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys
        355                 360                 365             
Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu
    370                 375                 380                 
Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr
385                 390                 395                 400 
Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu
                405                 410                 415     
Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp
            420                 425                 430         
Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val
        435                 440                 445             
Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu
    450                 455                 460                 
Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His
465                 470                 475                 480 
Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro
                485                 490                 495     
Gly Lys
        


<210> 13
<211> 816
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody-Exendin fusion

<400> 13
catggggagg gcactttcac tagcgacctg agcaagcaga tggaagaaga ggccgtgagg 60
ctgttcattg agtggctcaa gaacggaggc ccctcctccg gcgccccccc ccctagcggc 120
ggatccggag gcgggggcag tggcggggga ggtagcggtg agatcgtgct gacccagagc 180
cccctctcgc tgcccgtgac ccccggggag cccgccagca tctcctgccg cagtagccag 240
agcctgaggc attccaatgg ctacaactac ctggactggt acctgcagaa acccggccag 300
agcccccagc tgctcatcta cctggcgagt aaccgcgcca gcggggtgcc cgaccgcttc 360
agcggctccg gcagtggaac cgacttcacc ctgaagatct cccgcgtgga ggcggaggac 420
gtgggggtgt attactgtat gcaggccctc cagatccccc ccacgttcgg ccccggcacc 480
aaggtggaca tcaaacgcac cgtcgccgcc ccgaccgtga gcattttccc tcccagctcc 540
gagcagctga cgtccggcgg cgcctctgtg gtgtgcttcc tcaacaactt ctaccccaag 600
gacatcaacg tgaagtggaa gatcgacggc tccgagagac agaacggcgt gctgaacagc 660
tggaccgacc aggacagcaa ggactccacc tacagtatga gctccaccct gaccctgacc 720
aaggacgagt acgagaggca taactcttat acctgcgagg cgacccataa gaccagcacc 780
tcccccatcg tcaagagctt caaccgcaac gaatgc                           816

<210> 14
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody-Exendin fusion

<400> 14
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly
        35                  40                  45              
Gly Gly Gly Ser Gly Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu
    50                  55                  60                  
Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln
65                  70                  75                  80  
Ser Leu Arg His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln
                85                  90                  95      
Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg
            100                 105                 110         
Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
        115                 120                 125             
Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
    130                 135                 140                 
Tyr Cys Met Gln Ala Leu Gln Ile Pro Pro Thr Phe Gly Pro Gly Thr
145                 150                 155                 160 
Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Thr Val Ser Ile Phe
                165                 170                 175     
Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys
            180                 185                 190         
Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile
        195                 200                 205             
Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln
    210                 215                 220                 
Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr
225                 230                 235                 240 
Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His
                245                 250                 255     
Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
            260                 265                 270         


<210> 15
<211> 1443
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody-GLP-1 fusion

<400> 15
catggggagg gcaccttcac ctccgacgtc agctcttacc tcgagggcca agccgccaag 60
gagtttatcg cctggctcgt gaaggggagg acagtcgcgg cgcccagcca ggtgcagctg 120
gtgcagagcg gcgctgaggt gaagaagccc ggctcctccg tcaaggtcag ctgcaaggcg 180
agcgggcaga cattcaccgg atactacatg cattgggtgc gccaggcccc ggggcagggg 240
ctcgagtgga tggggagaat catccccatc ctgggcatcg ctcagaagtt ccagggacgc 300
gtgaccatca ccgccgacaa atccaccagc accgcctaca tggaactgag ctccctgcgc 360
tccgaggaca ccgccgtgta ttattgcgcc cgcgggggcg acctgggcgg catggacgtg 420
tggggccagg gcacactagt caccgtctcc tcagccaaaa caacagcccc atcggtctat 480
ccactggccc ctgtgtgtgg agatacaact ggctcctcgg tgactctagg atgcctggtc 540
aagggttatt tccctgagcc agtgaccttg acctggaact ctggatccct gtccagtggt 600
gtgcacacct tcccagctgt cctgcagtct gacctctaca ccctcagcag ctcagtgact 660
gtaacctcga gcacctggcc cagccagtcc atcacctgca atgtggccca cccggcaagc 720
agcaccaagg tggacaagaa aattgagccc agagggccca caatcaagcc ctgtcctcca 780
tgcaaatgcc cagcacctaa cctcgcgggt gcaccatccg tcttcatctt ccctccaaag 840
atcaaggatg tactcatgat ctccctgagc cccatagtca catgtgtggt ggtggatgtg 900
agcgaggatg acccagatgt ccagatcagc tggtttgtga acaacgtgga agtacacaca 960
gctcagacac aaacccatag agaggattac aacagtactc tccgggtggt cagtgccctc 1020
cccatccagc accaggactg gatgagtggc aaggagttca aatgcaaggt caacaacaaa 1080
gacctcccag cgcccatcga gagaaccatc tcaaaaccca aagggtcagt aagagctcca 1140
caggtatatg tcttgcctcc accagaagaa gagatgacta agaaacaggt cactctgacc 1200
tgcatggtca cagacttcat gcctgaagac atttacgtgg agtggaccaa caacgggaaa 1260
acagagctaa actacaagaa cactgaacca gtcctggact ctgatggttc ttacttcatg 1320
tacagcaagc tgagagtgga aaagaagaac tgggtggaaa gaaatagcta ctcctgttca 1380
gtggtccacg agggtctgca caatcaccac acgactaaga gcttctcccg gactccgggt 1440
aaa                                                               1443

<210> 16
<211> 481
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody-GLP-1 fusion

<400> 16
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Thr Val
            20                  25                  30          
Ala Ala Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
        35                  40                  45              
Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gln Thr
    50                  55                  60                  
Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
65                  70                  75                  80  
Leu Glu Trp Met Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Gln Lys
                85                  90                  95      
Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala
            100                 105                 110         
Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr
        115                 120                 125             
Cys Ala Arg Gly Gly Asp Leu Gly Gly Met Asp Val Trp Gly Gln Gly
    130                 135                 140                 
Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr
145                 150                 155                 160 
Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu
                165                 170                 175     
Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp
            180                 185                 190         
Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu
        195                 200                 205             
Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser
    210                 215                 220                 
Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser
225                 230                 235                 240 
Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys
                245                 250                 255     
Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Ala Gly Ala Pro
            260                 265                 270         
Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser
        275                 280                 285             
Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp
    290                 295                 300                 
Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr
305                 310                 315                 320 
Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val
                325                 330                 335     
Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu
            340                 345                 350         
Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg
        355                 360                 365             
Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val
    370                 375                 380                 
Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr
385                 390                 395                 400 
Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr
                405                 410                 415     
Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu
            420                 425                 430         
Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys
        435                 440                 445             
Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu
    450                 455                 460                 
Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly
465                 470                 475                 480 
Lys
    


<210> 17
<211> 765
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody-GLP-1 fusion

<400> 17
catggggagg gcaccttcac ctccgacgtc agctcttacc tcgagggcca agccgccaag 60
gagtttatcg cctggctcgt gaaggggagg acagtcgcgg cgcccagcga gatcgtgctg 120
acccagagcc ccctctcgct gcccgtgacc cccggggagc ccgccagcat ctcctgccgc 180
agtagccaga gcctgaggca ttccaatggc tacaactacc tggactggta cctgcagaaa 240
cccggccaga gcccccagct gctcatctac ctggcgagta accgcgccag cggggtgccc 300
gaccgcttca gcggctccgg cagtggaacc gacttcaccc tgaagatctc ccgcgtggag 360
gcggaggacg tgggggtgta ttactgtatg caggccctcc agatcccccc cacgttcggc 420
cccggcacca aggtggacat caaacgcacc gtcgccgccc cgaccgtgag cattttccct 480
cccagctccg agcagctgac gtccggcggc gcctctgtgg tgtgcttcct caacaacttc 540
taccccaagg acatcaacgt gaagtggaag atcgacggct ccgagagaca gaacggcgtg 600
ctgaacagct ggaccgacca ggacagcaag gactccacct acagtatgag ctccaccctg 660
accctgacca aggacgagta cgagaggcat aactcttata cctgcgaggc gacccataag 720
accagcacct cccccatcgt caagagcttc aaccgcaacg aatgc                 765

<210> 18
<211> 255
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody-GLP-1 fusion

<400> 18
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Thr Val
            20                  25                  30          
Ala Ala Pro Ser Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro
        35                  40                  45              
Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser
    50                  55                  60                  
Leu Arg His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys
65                  70                  75                  80  
Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Ala
                85                  90                  95      
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
            100                 105                 110         
Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr
        115                 120                 125             
Cys Met Gln Ala Leu Gln Ile Pro Pro Thr Phe Gly Pro Gly Thr Lys
    130                 135                 140                 
Val Asp Ile Lys Arg Thr Val Ala Ala Pro Thr Val Ser Ile Phe Pro
145                 150                 155                 160 
Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe
                165                 170                 175     
Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp
            180                 185                 190         
Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp
        195                 200                 205             
Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys
    210                 215                 220                 
Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys
225                 230                 235                 240 
Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
                245                 250                 255 


<210> 19
<211> 1512
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody-Exendin fusion

<400> 19
catggggagg gcactttcac tagcgacctg agcaagcaga tggaagaaga ggccgtgagg 60
ctgttcattg agtggctcaa gaacggaggc ccctcctccg gcgccccccc ccctagcggc 120
ggatccggag gcgggggcag tggcggggga ggtagcggtc aggtccaatt agtgcaatct 180
gggtctgagt tgaagaagcc tggggcctca gtgaaggttt cctgcaaggc ctctggatac 240
accttcacta actatggaat gaactgggtg cgacaggccc ctggacaagg gctcgagtgg 300
atgggatgga taaacaccag aaatggaaag tcaacatatg ttgatgactt caaggggcgg 360
tttgtcttct ccttggacac ctctgtcagc acggcatatc tacagatcag cagcctaaag 420
gctgacgaca ctgcagtgta ttactgtgcg agagaaggga atatggatgg ttacttccct 480
tttacttact ggggccaggg tacactagtc accgtctcct cagccaaaac aacagcccca 540
tcggtctatc cactggcccc tgtgtgtgga gatacaactg gctcctcggt gactctagga 600
tgcctggtca agggttattt ccctgagcca gtgaccttga cctggaactc tggctccctg 660
tccagtggtg tgcacacctt cccagctgtc ctgcagtctg acctctacac cctcagcagc 720
tcagtgactg taacctcgag cacctggccc agccagtcca tcacctgcaa tgtggcccac 780
ccggcaagca gcaccaaggt ggacaagaaa attgagccca gagggcccac aatcaagccc 840
tgtcctccat gcaaatgccc agcacctaac ctcgcgggtg caccatccgt cttcatcttc 900
cctccaaaga tcaaggatgt actcatgatc tccctgagcc ccatagtcac atgtgtggtg 960
gtggatgtga gcgaggatga cccagatgtc cagatcagct ggtttgtgaa caacgtggaa 1020
gtacacacag ctcagacaca aacccataga gaggattaca acagtactct ccgggtggtc 1080
agtgccctcc ccatccagca ccaggactgg atgagtggca aggagttcaa atgcaaggtc 1140
aacaacaaag acctcccagc gcccatcgag agaaccatct caaaacccaa agggtcagta 1200
agagctccac aggtatatgt cttgcctcca ccagaagaag agatgactaa gaaacaggtc 1260
actctgacct gcatggtcac agacttcatg cctgaagaca tttacgtgga gtggaccaac 1320
aacgggaaaa cagagctaaa ctacaagaac actgaaccag tcctggactc tgatggttct 1380
tacttcatgt acagcaagct gagagtggaa aagaagaact gggtggaaag aaatagctac 1440
tcctgttcag tggtccacga gggtctgcac aatcaccaca cgactaagag cttctcccgg 1500
actccgggta aa                                                     1512

<210> 20
<211> 504
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody-Exendin fusion

<400> 20
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly
        35                  40                  45              
Gly Gly Gly Ser Gly Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu
    50                  55                  60                  
Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
65                  70                  75                  80  
Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln
                85                  90                  95      
Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Arg Asn Gly Lys Ser Thr
            100                 105                 110         
Tyr Val Asp Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser
        115                 120                 125             
Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Asp Asp Thr
    130                 135                 140                 
Ala Val Tyr Tyr Cys Ala Arg Glu Gly Asn Met Asp Gly Tyr Phe Pro
145                 150                 155                 160 
Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys
                165                 170                 175     
Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr
            180                 185                 190         
Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro
        195                 200                 205             
Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val
    210                 215                 220                 
His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser
225                 230                 235                 240 
Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys
                245                 250                 255     
Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu
            260                 265                 270         
Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala
        275                 280                 285             
Pro Asn Leu Ala Gly Ala Pro Ser Val Phe Ile Phe Pro Pro Lys Ile
    290                 295                 300                 
Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val
305                 310                 315                 320 
Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val
                325                 330                 335     
Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp
            340                 345                 350         
Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln
        355                 360                 365             
Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp
    370                 375                 380                 
Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val
385                 390                 395                 400 
Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr
                405                 410                 415     
Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu
            420                 425                 430         
Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr
        435                 440                 445             
Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr
    450                 455                 460                 
Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr
465                 470                 475                 480 
Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys
                485                 490                 495     
Ser Phe Ser Arg Thr Pro Gly Lys
            500                 


<210> 21
<211> 801
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody-Exendin fusion

<400> 21
catggggagg gcactttcac tagcgacctg agcaagcaga tggaagaaga ggccgtgagg 60
ctgttcattg agtggctcaa gaacggaggc ccctcctccg gcgccccccc ccctagcggc 120
ggatccggag gcgggggcag tggcggggga ggtagcggtg atattgtcat gactcagtct 180
ccatcatccc tgtccgcatc agtaggagac agggtcacca tcacctgcaa ggcttctcag 240
aatgtgggta ctaatgtagc ctggtatcaa cagaaaccag ggaaagctcc taaagcactg 300
atttactcgg catcctatcg gtacagtgga gtccctgatc gcttctcagg cagtggctcc 360
gggacagatt tcactctcac catcagcagt ctgcagcctg aagacttcgc aacgtattac 420
tgtcagcaat ataacagcta tcctctcacg ttcggtggtg gtaccaaggt ggaaataaaa 480
cgtacggtcg ccgccccgac cgtgagcatt ttccctccca gctccgagca gctgacgtcc 540
ggcggcgcct ctgtggtgtg cttcctcaac aacttctacc ccaaggacat caacgtgaag 600
tggaagatcg acggctccga gagacagaac ggcgtgctga acagctggac cgaccaggac 660
agcaaggact ccacctacag tatgagctcc accctgaccc tgaccaagga cgagtacgag 720
aggcataact cttatacctg cgaggcgacc cataagacca gcacctcccc catcgtcaag 780
agcttcaacc gcaacgaatg c                                           801

<210> 22
<211> 267
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody-Exendin fusion

<400> 22
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly
        35                  40                  45              
Gly Gly Gly Ser Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu
    50                  55                  60                  
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln
65                  70                  75                  80  
Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala
                85                  90                  95      
Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro
            100                 105                 110         
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
        115                 120                 125             
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr
    130                 135                 140                 
Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
145                 150                 155                 160 
Arg Thr Val Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu
                165                 170                 175     
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe
            180                 185                 190         
Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg
        195                 200                 205             
Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser
    210                 215                 220                 
Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu
225                 230                 235                 240 
Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser
                245                 250                 255     
Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
            260                 265         


<210> 23
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence
      

<400> 23
gatattgtca tgactcagtc tccatcatcc ctgtccgcat cagtaggaga cagggtcacc 60
atcacctgca aggcttctca gaatgtgggt actaatgtag cctggtatca acagaaacca 120
gggaaagctc ctaaagcact gatttactcg gcatcctatc ggtacagtgg agtccctgat 180
cgcttctcag gcagtggatc cgggacagat ttcactctca ccatcagcag tctgcagcct 240
gaagacttcg caacgtatta ctgtcagcaa tataacagct atcctctcac gttcggtggt 300
ggtaccaagg tggaaataaa acgtacggtg gccgccccga ccgtgagcat tttccctccc 360
agctccgagc agctgacgtc cggcggcgcc tctgtggtgt gcttcctcaa caacttctac 420
cccaaggaca tcaacgtgaa gtggaagatc gacggctccg agagacagaa cggcgtgctg 480
aacagctgga ccgaccagga cagcaaggac tccacctaca gtatgagctc caccctgacc 540
ctgaccaagg acgagtacga gaggcataac tcttatacct gcgaggcgac ccataagacc 600
agcacctccc ccatcgtcaa gagcttcaac cgcaacgaat gc                    642

<210> 24
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence
      

<400> 24
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly
        115                 120                 125             
Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile
    130                 135                 140                 
Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu
145                 150                 155                 160 
Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr
            180                 185                 190         
Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser
        195                 200                 205             
Phe Asn Arg Asn Glu Cys
    210                 


<210> 25
<211> 1482
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody-GLP-1 fusion
      

<400> 25
catggggagg gcaccttcac ctccgacgtc agctcttacc tcgagggcca agccgccaag 60
gagtttatcg cctggctcgt gaaggggagg ggatccggag gcgggggcag tggcggggga 120
ggtagcggtc aggtccaatt agtgcaatct gggtctgagt tgaagaagcc tggggcctca 180
gtgaaggttt cctgcaaggc ctctggatac accttcacta actatggaat gaactgggtg 240
cgacaggccc ctggacaagg gctcgagtgg atgggatgga taaacaccag aaatggaaag 300
tcaacatatg ttgatgactt caaggggcgg tttgtcttct ccttggacac ctctgtcagc 360
acggcatatc tacagatcag cagcctaaag gctgacgaca ctgcagtgta ttactgtgcg 420
agagaaggga atatggatgg ttacttccct tttacttact ggggccaggg tacactagtc 480
accgtctcct cagccaaaac aacagcccca tcggtctatc cactggcccc tgtgtgtgga 540
gatacaactg gctcctcggt gactctagga tgcctggtca agggttattt ccctgagcca 600
gtgaccttga cctggaactc tggctccctg tccagtggtg tgcacacctt cccagctgtc 660
ctgcagtctg acctctacac cctcagcagc tcagtgactg taacctcgag cacctggccc 720
agccagtcca tcacctgcaa tgtggcccac ccggcaagca gcaccaaggt ggacaagaaa 780
attgagccca gagggcccac aatcaagccc tgtcctccat gcaaatgccc agcacctaac 840
ctcgcgggtg caccatccgt cttcatcttc cctccaaaga tcaaggatgt actcatgatc 900
tccctgagcc ccatagtcac atgtgtggtg gtggatgtga gcgaggatga cccagatgtc 960
cagatcagct ggtttgtgaa caacgtggaa gtacacacag ctcagacaca aacccataga 1020
gaggattaca acagtactct ccgggtggtc agtgccctcc ccatccagca ccaggactgg 1080
atgagtggca aggagttcaa atgcaaggtc aacaacaaag acctcccagc gcccatcgag 1140
agaaccatct caaaacccaa agggtcagta agagctccac aggtatatgt cttgcctcca 1200
ccagaagaag agatgactaa gaaacaggtc actctgacct gcatggtcac agacttcatg 1260
cctgaagaca tttacgtgga gtggaccaac aacgggaaaa cagagctaaa ctacaagaac 1320
actgaaccag tcctggactc tgatggttct tacttcatgt acagcaagct gagagtggaa 1380
aagaagaact gggtggaaag aaatagctac tcctgttcag tggtccacga gggtctgcac 1440
aatcaccaca cgactaagag cttctcccgg actccgggta aa                    1482

<210> 26
<211> 494
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody-GLP-1 fusion
      

<400> 26
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Ser
            20                  25                  30          
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gln Val Gln Leu Val
        35                  40                  45              
Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser
    50                  55                  60                  
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val
65                  70                  75                  80  
Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr
                85                  90                  95      
Arg Asn Gly Lys Ser Thr Tyr Val Asp Asp Phe Lys Gly Arg Phe Val
            100                 105                 110         
Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser
        115                 120                 125             
Leu Lys Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Asn
    130                 135                 140                 
Met Asp Gly Tyr Phe Pro Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val
145                 150                 155                 160 
Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala
                165                 170                 175     
Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu
            180                 185                 190         
Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly
        195                 200                 205             
Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp
    210                 215                 220                 
Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro
225                 230                 235                 240 
Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys
                245                 250                 255     
Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro
            260                 265                 270         
Pro Cys Lys Cys Pro Ala Pro Asn Leu Ala Gly Ala Pro Ser Val Phe
        275                 280                 285             
Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro
    290                 295                 300                 
Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val
305                 310                 315                 320 
Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr
                325                 330                 335     
Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala
            340                 345                 350         
Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys
        355                 360                 365             
Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser
    370                 375                 380                 
Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro
385                 390                 395                 400 
Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val
                405                 410                 415     
Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly
            420                 425                 430         
Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp
        435                 440                 445             
Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp
    450                 455                 460                 
Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His
465                 470                 475                 480 
Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
                485                 490                 


<210> 27
<211> 771
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody-GLP-1 fusion
      

<400> 27
catggggagg gcaccttcac ctccgacgtc agctcttacc tcgagggcca agccgccaag 60
gagtttatcg cctggctcgt gaaggggagg ggatccggag gcgggggcag tggcggggga 120
ggtagcggtg atattgtcat gactcagtct ccatcatccc tgtccgcatc agtaggagac 180
agggtcacca tcacctgcaa ggcttctcag aatgtgggta ctaatgtagc ctggtatcaa 240
cagaaaccag ggaaagctcc taaagcactg atttactcgg catcctatcg gtacagtgga 300
gtccctgatc gcttctcagg cagtggctcc gggacagatt tcactctcac catcagcagt 360
ctgcagcctg aagacttcgc aacgtattac tgtcagcaat ataacagcta tcctctcacg 420
ttcggtggtg gtaccaaggt ggaaataaaa cgtacggtcg ccgccccgac cgtgagcatt 480
ttccctccca gctccgagca gctgacgtcc ggcggcgcct ctgtggtgtg cttcctcaac 540
aacttctacc ccaaggacat caacgtgaag tggaagatcg acggctccga gagacagaac 600
ggcgtgctga acagctggac cgaccaggac agcaaggact ccacctacag tatgagctcc 660
accctgaccc tgaccaagga cgagtacgag aggcataact cttatacctg cgaggcgacc 720
cataagacca gcacctcccc catcgtcaag agcttcaacc gcaacgaatg c          771

<210> 28
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody-GLP-1 fusion
      

<400> 28
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Ser
            20                  25                  30          
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asp Ile Val Met Thr
        35                  40                  45              
Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
    50                  55                  60                  
Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln
65                  70                  75                  80  
Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr
                85                  90                  95      
Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
            100                 105                 110         
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
        115                 120                 125             
Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly
    130                 135                 140                 
Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Thr Val Ser Ile
145                 150                 155                 160 
Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val
                165                 170                 175     
Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys
            180                 185                 190         
Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp
        195                 200                 205             
Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu
    210                 215                 220                 
Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr
225                 230                 235                 240 
His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu
                245                 250                 255     
Cys
    


<210> 29
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence
      

<400> 29
caggtgcagc tggtgcagag cggcgctgag gtgaagaagc ccggctcctc cgtcaaggtc 60
agctgcaagg cgagcgggca gacattcacc ggatactaca tgcattgggt gcgccaggcc 120
ccggggcagg ggctcgagtg gatggggaga atcatcccca tcctgggcat cgctcagaag 180
ttccagggac gcgtgaccat caccgccgac aaatccacca gcaccgccta catggaactg 240
agctccctgc gctccgagga caccgccgtg tattattgcg cccgcggggg cgacctgggc 300
ggcatggacg tgtggggcca gggc                                        324

<210> 30
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence
      

<400> 30
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gln Thr Phe Thr Gly Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Gln Lys Phe Gln Gly Arg
    50                  55                  60                  
Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu
65                  70                  75                  80  
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly
                85                  90                  95      
Gly Asp Leu Gly Gly Met Asp Val Trp Gly Gln Gly
            100                 105             


<210> 31
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence
      

<400> 31
gagatcgtgc tgacccagag ccccctctcg ctgcccgtga cccccgggga gcccgccagc 60
atctcctgcc gcagtagcca gagcctgagg cattccaatg gctacaacta cctggactgg 120
tacctgcaga aacccggcca gagcccccag ctgctcatct acctggcgag taaccgcgcc 180
agcggggtgc ccgaccgctt cagcggctcc ggcagtggaa ccgacttcac cctgaagatc 240
tcccgcgtgg aggcggagga cgtgggggtg tattactgta tgcaggccct ccagatcccc 300
cccacgttcg gccccggcac caaggtggac atcaaacgca ccgtcgccgc c          351

<210> 32
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence
      

<400> 32
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
 1               5                  10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Arg His Ser
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Ala Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
                85                  90                  95      
Leu Gln Ile Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
            100                 105                 110         
Arg Thr Val Ala Ala
        115         


<210> 33
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> signal sequence
      

<400> 33
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser
            


<210> 34
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker
      

<400> 34
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15      
Ser Gly Gly Gly Gly Ser Gly
            20              


<210> 35
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker
      

<400> 35
Thr Val Ala Ala Pro Ser
 1               5      


<210> 36
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker
      

<400> 36
Ala Ser Thr Lys Gly Pro Ser
 1               5          


<210> 37
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker
      

<400> 37
Gly Ser Ser Ser Ser
 1               5  

