                         SEQUENCE LISTING

<110>  GlobeImmune, Inc.
       United States of America, as represented by the Secretary, 
       Department of Health and Human Services
       Hodge, James
       Schlom, Jeffrey
       Franzusoff, Alex
 
<120>  Combination Immunotherapy Compositions and Methods

<130>  3923-24-PCT

<150>  61/170,530
<151>  2009-04-17

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  2124
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct


<220>
<221>  CDS
<222>  (7)..(2109)

<400>  1
gaattc atg gag tct ccc tcg gcc cct ccc cac aga tgg tgc atc ccc          48
       Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro            
       1               5                   10                             

tgg cag agg ctc ctg ctc aca gcc tca ctt cta acc ttc tgg aac ccg         96
Trp Gln Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro           
15                  20                  25                  30            

ccc acc act gcc aag ctc act att gaa tcc acg ccg ttc aat gtc gca        144
Pro Thr Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala           
                35                  40                  45                

gag ggg aag gag gtg ctt cta ctt gtc cac aat ctg ccc cag cat ctt        192
Glu Gly Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu           
            50                  55                  60                    

ttt ggc tac agc tgg tac aaa ggt gaa aga gtg gat ggc aac cgt caa        240
Phe Gly Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln           
        65                  70                  75                        

att ata gga tat gta ata gga act caa caa gct acc cca ggg ccc gca        288
Ile Ile Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala           
    80                  85                  90                            

tac agt ggt cga gag ata ata tac ccc aat gca tcc ctg ctg atc cag        336
Tyr Ser Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln           
95                  100                 105                 110           

aac atc atc cag aat gac aca gga ttc tac acc cta cac gtc ata aag        384
Asn Ile Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys           
                115                 120                 125               

tca gat ctt gtg aat gaa gaa gca act ggc cag ttc cgg gta tac ccg        432
Ser Asp Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro           
            130                 135                 140                   

gag ctg ccc aag ccc tcc atc tcc agc aac aac tcc aaa ccc gtg gag        480
Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu           
        145                 150                 155                       

gac aag gat gct gtg gcc ttc acc tgt gaa cct gag act cag gac gca        528
Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala           
    160                 165                 170                           

acc tac ctg tgg tgg gta aac aat cag agc ctc ccg gtc agt ccc agg        576
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg           
175                 180                 185                 190           

ctg cag ctg tcc aat ggc aac agg acc ctc act cta ttc aat gtc aca        624
Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr           
                195                 200                 205               

aga aat gac aca gca agc tac aaa tgt gaa acc cag aac cca gtg agt        672
Arg Asn Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser           
            210                 215                 220                   

gcc agg cgc agt gat tca gtc atc ctg aat gtc ctc tat ggc ccg gat        720
Ala Arg Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp           
        225                 230                 235                       

gcc ccc acc att tcc cct cta aac aca tct tac aga tca ggg gaa aat        768
Ala Pro Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn           
    240                 245                 250                           

ctg aac ctc tcc tgc cac gca gcc tct aac cca cct gca cag tac tct        816
Leu Asn Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser           
255                 260                 265                 270           

tgg ttt gtc aat ggg act ttc cag caa tcc acc caa gag ctc ttt atc        864
Trp Phe Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile           
                275                 280                 285               

ccc aac atc act gtg aat aat agt gga tcc tat acg tgc caa gcc cat        912
Pro Asn Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His           
            290                 295                 300                   

aac tca gac act ggc ctc aat agg acc aca gtc acg acg atc aca gtc        960
Asn Ser Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val           
        305                 310                 315                       

tat gag cca ccc aaa ccc ttc atc acc agc aac aac tcc aac ccc gtg       1008
Tyr Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val           
    320                 325                 330                           

gag gat gag gat gct gta gcc tta acc tgt gaa cct gag att cag aac       1056
Glu Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn           
335                 340                 345                 350           

aca acc tac ctg tgg tgg gta aat aat cag agc ctc ccg gtc agt ccc       1104
Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro           
                355                 360                 365               

agg ctg cag ctg tcc aat gac aac agg acc ctc act cta ctc agt gtc       1152
Arg Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val           
            370                 375                 380                   

aca agg aat gat gta gga ccc tat gag tgt gga atc cag aac gaa tta       1200
Thr Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu           
        385                 390                 395                       

agt gtt gac cac agc gac cca gtc atc ctg aat gtc ctc tat ggc cca       1248
Ser Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro           
    400                 405                 410                           

gac gac ccc acc att tcc ccc tca tac acc tat tac cgt cca ggg gtg       1296
Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val           
415                 420                 425                 430           

aac ctc agc ctc tcc tgc cat gca gcc tct aac cca cct gca cag tat       1344
Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr           
                435                 440                 445               

tct tgg ctg att gat ggg aac atc cag caa cac aca caa gag ctc ttt       1392
Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe           
            450                 455                 460                   

atc tcc aac atc act gag aag aac agc gga ctc tat acc tgc cag gcc       1440
Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala           
        465                 470                 475                       

aat aac tca gcc agt ggc cac agc agg act aca gtc aag aca atc aca       1488
Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr           
    480                 485                 490                           

gtc tct gcg gag ctg ccc aag ccc tcc atc tcc agc aac aac tcc aaa       1536
Val Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys           
495                 500                 505                 510           

ccc gtg gag gac aag gat gct gtg gcc ttc acc tgt gaa cct gag gct       1584
Pro Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala           
                515                 520                 525               

cag aac aca acc tac ctg tgg tgg gta aat ggt cag agc ctc cca gtc       1632
Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val           
            530                 535                 540                   

agt ccc agg ctg cag ctg tcc aat ggc aac agg acc ctc act cta ttc       1680
Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe           
        545                 550                 555                       

aat gtc aca aga aat gac gca aga gcc tat gta tgt gga atc cag aac       1728
Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn           
    560                 565                 570                           

tca gtg agt gca aac cgc agt gac cca gtc acc ctg gat gtc ctc tat       1776
Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr           
575                 580                 585                 590           

ggg ccg gac acc ccc atc att tcc ccc cca gac tcg tct tac ctt tcg       1824
Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser           
                595                 600                 605               

gga gcg gac ctc aac ctc tcc tgc cac tcg gcc tct aac cca tcc ccg       1872
Gly Ala Asp Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro           
            610                 615                 620                   

cag tat tct tgg cgt atc aat ggg ata ccg cag caa cac aca caa gtt       1920
Gln Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val           
        625                 630                 635                       

ctc ttt atc gcc aaa atc acg cca aat aat aac ggg acc tat gcc tgt       1968
Leu Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys           
    640                 645                 650                           

ttt gtc tct aac ttg gct act ggc cgc aat aat tcc ata gtc aag agc       2016
Phe Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser           
655                 660                 665                 670           

atc aca gtc tct gca tct gga act tct cct ggt ctc tca gct ggg gcc       2064
Ile Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala           
                675                 680                 685               

act gtc ggc atc atg att gga gtg ctg gtt ggg gtt gct ctg ata           2109
Thr Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile               
            690                 695                 700                   

tagtttagcg gccgc                                                      2124


<210>  2
<211>  701
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  2

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Glu 
305                 310                 315                 320 


Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp 
                325                 330                 335     


Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr 
            340                 345                 350         


Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu 
        355                 360                 365             


Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg 
    370                 375                 380                 


Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val 
385                 390                 395                 400 


Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp 
                405                 410                 415     


Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu 
            420                 425                 430         


Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp 
        435                 440                 445             


Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser 
    450                 455                 460                 


Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn 
465                 470                 475                 480 


Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser 
                485                 490                 495     


Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val 
            500                 505                 510         


Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn 
        515                 520                 525             


Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro 
    530                 535                 540                 


Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val 
545                 550                 555                 560 


Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val 
                565                 570                 575     


Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro 
            580                 585                 590         


Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala 
        595                 600                 605             


Asp Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr 
    610                 615                 620                 


Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe 
625                 630                 635                 640 


Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val 
                645                 650                 655     


Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr 
            660                 665                 670         


Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val 
        675                 680                 685             


Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700     


<210>  3
<211>  537
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct


<220>
<221>  CDS
<222>  (1)..(534)

<400>  3
atg gtc ctc gac aca gca ggt ttg gag gag tac agt gca atg act gag         48
Met Val Leu Asp Thr Ala Gly Leu Glu Glu Tyr Ser Ala Met Thr Glu           
1               5                   10                  15                

tat aaa ctt gtg gtg gtt gga gct gtt ggc gta ggc aag agc gcc ttg         96
Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys Ser Ala Leu           
            20                  25                  30                    

acg ata cag cta att cag aat cac ttt gtg gat gag tac gac cct acg        144
Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr Asp Pro Thr           
        35                  40                  45                        

ata gag gac tcc tac agg aaa caa gta gta att gat gga gaa acc tgt        192
Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr Cys           
    50                  55                  60                            

ctc ttg gat att ctc gac aca gca ggt cga gag gag tac agt gca atg        240
Leu Leu Asp Ile Leu Asp Thr Ala Gly Arg Glu Glu Tyr Ser Ala Met           
65                  70                  75                  80            

agg gac cag tac atg aga act ggg gag ggc ttt ctt tgt gta ttt gcc        288
Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys Val Phe Ala           
                85                  90                  95                

ata aat aat act aaa tca ttt gaa gat att cac cat tat aga gaa caa        336
Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr Arg Glu Gln           
            100                 105                 110                   

att aaa aga gta aag gac tct gaa gat gtg cct atg gtc ctg gta ggg        384
Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val Leu Val Gly           
        115                 120                 125                       

aat aag tgt gat ttg cct tct aga aca gta gac acg aaa cag gct cag        432
Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys Gln Ala Gln           
    130                 135                 140                           

gag tta gca agg agt tac ggg att ccg ttc att gag acc tca gca aag        480
Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr Ser Ala Lys           
145                 150                 155                 160           

aca aga cag ggt gtt gac gat gcc ttc tat aca tta gtc cga gaa att        528
Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile           
                165                 170                 175               

cga aaa tag                                                            537
Arg Lys                                                                   
                                                                          


<210>  4
<211>  178
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  4

Met Val Leu Asp Thr Ala Gly Leu Glu Glu Tyr Ser Ala Met Thr Glu 
1               5                   10                  15      


Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys Ser Ala Leu 
            20                  25                  30          


Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr Asp Pro Thr 
        35                  40                  45              


Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr Cys 
    50                  55                  60                  


Leu Leu Asp Ile Leu Asp Thr Ala Gly Arg Glu Glu Tyr Ser Ala Met 
65                  70                  75                  80  


Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys Val Phe Ala 
                85                  90                  95      


Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr Arg Glu Gln 
            100                 105                 110         


Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val Leu Val Gly 
        115                 120                 125             


Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys Gln Ala Gln 
    130                 135                 140                 


Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr Ser Ala Lys 
145                 150                 155                 160 


Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile 
                165                 170                 175     


Arg Lys 
        


<210>  5
<211>  537
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(534)

<400>  5
atg gtc ctc gac aca gca ggt ttg gag gag tac agt gca atg act gag         48
Met Val Leu Asp Thr Ala Gly Leu Glu Glu Tyr Ser Ala Met Thr Glu           
1               5                   10                  15                

tat aaa ctt gtg gtg gtt gga gct tgt ggc gta ggc aag agc gcc ttg         96
Tyr Lys Leu Val Val Val Gly Ala Cys Gly Val Gly Lys Ser Ala Leu           
            20                  25                  30                    

acg ata cag cta att cag aat cac ttt gtg gat gag tac gac cct acg        144
Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr Asp Pro Thr           
        35                  40                  45                        

ata gag gac tcc tac agg aaa caa gta gta att gat gga gaa acc tgt        192
Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr Cys           
    50                  55                  60                            

ctc ttg gat att ctc gac aca gca ggt cga gag gag tac agt gca atg        240
Leu Leu Asp Ile Leu Asp Thr Ala Gly Arg Glu Glu Tyr Ser Ala Met           
65                  70                  75                  80            

agg gac cag tac atg aga act ggg gag ggc ttc ctt tgt gta ttt gcc        288
Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys Val Phe Ala           
                85                  90                  95                

ata aat aat act aaa tca ttt gaa gat att cac cat tat aga gaa caa        336
Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr Arg Glu Gln           
            100                 105                 110                   

att aaa aga gta aag gac tct gaa gat gtg cct atg gtc ctg gta ggg        384
Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val Leu Val Gly           
        115                 120                 125                       

aat aag tgt gat ttg cct tct aga aca gta gac acg aaa cag gct cag        432
Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys Gln Ala Gln           
    130                 135                 140                           

gag tta gca agg agt tac ggg att ccg ttc att gag acc tca gca aag        480
Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr Ser Ala Lys           
145                 150                 155                 160           

aca aga cag ggt gtt gac gat gcc ttc tat aca tta gtc cga gaa att        528
Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile           
                165                 170                 175               

cga aaa tag                                                            537
Arg Lys                                                                   
                                                                          


<210>  6
<211>  178
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  6

Met Val Leu Asp Thr Ala Gly Leu Glu Glu Tyr Ser Ala Met Thr Glu 
1               5                   10                  15      


Tyr Lys Leu Val Val Val Gly Ala Cys Gly Val Gly Lys Ser Ala Leu 
            20                  25                  30          


Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr Asp Pro Thr 
        35                  40                  45              


Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr Cys 
    50                  55                  60                  


Leu Leu Asp Ile Leu Asp Thr Ala Gly Arg Glu Glu Tyr Ser Ala Met 
65                  70                  75                  80  


Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys Val Phe Ala 
                85                  90                  95      


Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr Arg Glu Gln 
            100                 105                 110         


Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val Leu Val Gly 
        115                 120                 125             


Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys Gln Ala Gln 
    130                 135                 140                 


Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr Ser Ala Lys 
145                 150                 155                 160 


Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile 
                165                 170                 175     


Arg Lys 
        


<210>  7
<211>  537
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(534)

<400>  7
atg gtc ctc gac aca gca ggt ttg gag gag tac agt gca atg act gag         48
Met Val Leu Asp Thr Ala Gly Leu Glu Glu Tyr Ser Ala Met Thr Glu           
1               5                   10                  15                

tat aaa ctt gtg gtg gtt gga gct gat ggc gta ggc aag agc gcc ttg         96
Tyr Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys Ser Ala Leu           
            20                  25                  30                    

acg ata cag cta att cag aat cac ttt gtg gat gag tac gac cct acg        144
Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr Asp Pro Thr           
        35                  40                  45                        

ata gag gac tcc tac agg aaa caa gta gta att gat gga gaa acc tgt        192
Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr Cys           
    50                  55                  60                            

ctc ttg gat att ctc gac aca gca ggt cga gag gag tac agt gca atg        240
Leu Leu Asp Ile Leu Asp Thr Ala Gly Arg Glu Glu Tyr Ser Ala Met           
65                  70                  75                  80            

agg gac cag tac atg aga act ggg gag ggc ttt ctt tgt gta ttt gcc        288
Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys Val Phe Ala           
                85                  90                  95                

ata aat aat act aaa tca ttt gaa gat att cac cat tat aga gaa caa        336
Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr Arg Glu Gln           
            100                 105                 110                   

att aaa aga gta aag gac tct gaa gat gtg cct atg gtc ctg gta ggg        384
Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val Leu Val Gly           
        115                 120                 125                       

aat aag tgt gat ttg cct tct aga aca gta gac acg aaa cag gct cag        432
Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys Gln Ala Gln           
    130                 135                 140                           

gag tta gca agg agt tac ggg att ccg ttc att gag acc tca gca aag        480
Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr Ser Ala Lys           
145                 150                 155                 160           

aca aga cag ggt gtt gac gat gcc ttc tat aca tta gtc cga gaa att        528
Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile           
                165                 170                 175               

cga aaa tag                                                            537
Arg Lys                                                                   
                                                                          


<210>  8
<211>  178
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  8

Met Val Leu Asp Thr Ala Gly Leu Glu Glu Tyr Ser Ala Met Thr Glu 
1               5                   10                  15      


Tyr Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys Ser Ala Leu 
            20                  25                  30          


Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr Asp Pro Thr 
        35                  40                  45              


Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr Cys 
    50                  55                  60                  


Leu Leu Asp Ile Leu Asp Thr Ala Gly Arg Glu Glu Tyr Ser Ala Met 
65                  70                  75                  80  


Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys Val Phe Ala 
                85                  90                  95      


Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr Arg Glu Gln 
            100                 105                 110         


Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val Leu Val Gly 
        115                 120                 125             


Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys Gln Ala Gln 
    130                 135                 140                 


Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr Ser Ala Lys 
145                 150                 155                 160 


Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile 
                165                 170                 175     


Arg Lys 
        


<210>  9
<211>  537
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(534)

<400>  9
atg gtc ctc gac aca gca ggt ttg gag gag tac agt gca atg act gag         48
Met Val Leu Asp Thr Ala Gly Leu Glu Glu Tyr Ser Ala Met Thr Glu           
1               5                   10                  15                

tat aaa ctt gtg gtg gtt gga gct cgt ggc gta ggc aag agc gcc ttg         96
Tyr Lys Leu Val Val Val Gly Ala Arg Gly Val Gly Lys Ser Ala Leu           
            20                  25                  30                    

acg ata cag cta att cag aat cac ttt gtg gat gag tac gac cct acg        144
Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr Asp Pro Thr           
        35                  40                  45                        

ata gag gac tcc tac agg aaa caa gta gta att gat gga gaa acc tgt        192
Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr Cys           
    50                  55                  60                            

ctc ttg gat att ctc gac aca gca ggt cac gag gag tac agt gca atg        240
Leu Leu Asp Ile Leu Asp Thr Ala Gly His Glu Glu Tyr Ser Ala Met           
65                  70                  75                  80            

agg gac cag tac atg aga act ggg gag ggc ttt ctt tgt gta ttt gcc        288
Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys Val Phe Ala           
                85                  90                  95                

ata aat aat act aaa tca ttt gaa gat att cac cat tat aga gaa caa        336
Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr Arg Glu Gln           
            100                 105                 110                   

att aaa aga gta aag gac tct gaa gat gtg cct atg gtc ctg gta ggg        384
Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val Leu Val Gly           
        115                 120                 125                       

aat aag tgt gat ttg cct tct aga aca gta gac acg aaa cag gct cag        432
Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys Gln Ala Gln           
    130                 135                 140                           

gag tta gca agg agt tac ggg att ccg ttc att gag acc tca gca aag        480
Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr Ser Ala Lys           
145                 150                 155                 160           

aca aga cag ggt gtt gac gat gcc ttc tat aca tta gtc cga gaa att        528
Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile           
                165                 170                 175               

cga aaa tag                                                            537
Arg Lys                                                                   
                                                                          


<210>  10
<211>  178
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  10

Met Val Leu Asp Thr Ala Gly Leu Glu Glu Tyr Ser Ala Met Thr Glu 
1               5                   10                  15      


Tyr Lys Leu Val Val Val Gly Ala Arg Gly Val Gly Lys Ser Ala Leu 
            20                  25                  30          


Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr Asp Pro Thr 
        35                  40                  45              


Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr Cys 
    50                  55                  60                  


Leu Leu Asp Ile Leu Asp Thr Ala Gly His Glu Glu Tyr Ser Ala Met 
65                  70                  75                  80  


Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys Val Phe Ala 
                85                  90                  95      


Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr Arg Glu Gln 
            100                 105                 110         


Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val Leu Val Gly 
        115                 120                 125             


Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys Gln Ala Gln 
    130                 135                 140                 


Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr Ser Ala Lys 
145                 150                 155                 160 


Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile 
                165                 170                 175     


Arg Lys 
        


<210>  11
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  11

Gly Ile Gln Asn Ser Val Ser Ala 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  12

Glu Ala Gln Asn Thr Thr Tyr Leu 
1               5               


<210>  13
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  13

Ser Gln Val Thr Asn Pro Ala Asn Ile 
1               5                   


<210>  14
<211>  2518
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (494)..(1801)

<400>  14
tttgcttttg cttatttccg tccatttccc tctctgcgcg cggaccttcc ttttccagat       60

ggtgagagcc gcggggacac ccgacgccgg ggcaggctga tccacgatcc tgggtgtgcg      120

taacgccgcc tggggctccg tgggcgaggg acgtgtgggg acaggtgcac cggaaactgc      180

cagactggag agttgaggca tcggaggcgc gagaacagca ctactactgc ggcgagacga      240

gcgcggcgca tcccaaagcc cggccaaatg cgctcgtccc tgggagggga gggaggcgcg      300

cctggagcgg ggacagtctt ggtccgcgcc ctcctcccgg gtctgtgccg ggacccggga      360

cccgggagcc gtcgcaggtc tcggtccaag gggccccttt tctcggaagg gcggcggcca      420

agagcaggga aggtggatct caggtagcga gtctgggctt cggggacggc ggggagggga      480

gccggacggg agg atg agc tcc cct ggc acc gag agc gcg gga aag agc         529
               Met Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys Ser            
               1               5                   10                     

ctg cag tac cga gtg gac cac ctg ctg agc gcc gtg gag aat gag ctg        577
Leu Gln Tyr Arg Val Asp His Leu Leu Ser Ala Val Glu Asn Glu Leu           
        15                  20                  25                        

cag gcg ggc agc gag aag ggc gac ccc aca gag cgc gaa ctg cgc gtg        625
Gln Ala Gly Ser Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg Val           
    30                  35                  40                            

ggc ctg gag gag agc gag ctg tgg ctg cgc ttc aag gag ctc acc aat        673
Gly Leu Glu Glu Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr Asn           
45                  50                  55                  60            

gag atg atc gtg acc aag aac ggc agg agg atg ttt ccg gtg ctg aag        721
Glu Met Ile Val Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu Lys           
                65                  70                  75                

gtg aac gtg tct ggc ctg gac ccc aac gcc atg tac tcc ttc ctg ctg        769
Val Asn Val Ser Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu Leu           
            80                  85                  90                    

gac ttc gtg gcg gcg gac aac cac cgc tgg aag tac gtg aac ggg gaa        817
Asp Phe Val Ala Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly Glu           
        95                  100                 105                       

tgg gtg ccg ggg ggc aag ccg gag ccg cag gcg ccc agc tgc gtc tac        865
Trp Val Pro Gly Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val Tyr           
    110                 115                 120                           

atc cac ccc gac tcg ccc aac ttc ggg gcc cac tgg atg aag gct ccc        913
Ile His Pro Asp Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala Pro           
125                 130                 135                 140           

gtc tcc ttc agc aaa gtc aag ctc acc aac aag ctc aac gga ggg ggc        961
Val Ser Phe Ser Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly Gly           
                145                 150                 155               

cag atc atg ctg aac tcc ttg cat aag tat gag cct cga atc cac ata       1009
Gln Ile Met Leu Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His Ile           
            160                 165                 170                   

gtg aga gtt ggg ggt cca cag cgc atg atc acc agc cac tgc ttc cct       1057
Val Arg Val Gly Gly Pro Gln Arg Met Ile Thr Ser His Cys Phe Pro           
        175                 180                 185                       

gag acc cag ttc ata gcg gtg act gct tat cag aac gag gag atc aca       1105
Glu Thr Gln Phe Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile Thr           
    190                 195                 200                           

gct ctt aaa att aag tac aat cca ttt gca aaa gct ttc ctt gat gca       1153
Ala Leu Lys Ile Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp Ala           
205                 210                 215                 220           

aag gaa aga agt gat cac aaa gag atg atg gag gaa ccc gga gac agc       1201
Lys Glu Arg Ser Asp His Lys Glu Met Met Glu Glu Pro Gly Asp Ser           
                225                 230                 235               

cag caa cct ggg tac tcc caa tgg ggg tgg ctt ctt cct gga acc agc       1249
Gln Gln Pro Gly Tyr Ser Gln Trp Gly Trp Leu Leu Pro Gly Thr Ser           
            240                 245                 250                   

acc ctg tgt cca cct gca aat cct cat cct cag ttt gga ggt gcc ctc       1297
Thr Leu Cys Pro Pro Ala Asn Pro His Pro Gln Phe Gly Gly Ala Leu           
        255                 260                 265                       

tcc ctc ccc tcc acg cac agc tgt gac agg tac cca acc ctg agg agc       1345
Ser Leu Pro Ser Thr His Ser Cys Asp Arg Tyr Pro Thr Leu Arg Ser           
    270                 275                 280                           

cac cgg tcc tca ccc tac ccc agc ccc tat gct cat cgg aac aat tct       1393
His Arg Ser Ser Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Asn Ser           
285                 290                 295                 300           

cca acc tat tct gac aac tca cct gca tgt tta tcc atg ctg caa tcc       1441
Pro Thr Tyr Ser Asp Asn Ser Pro Ala Cys Leu Ser Met Leu Gln Ser           
                305                 310                 315               

cat gac aat tgg tcc agc ctt gga atg cct gcc cat ccc agc atg ctc       1489
His Asp Asn Trp Ser Ser Leu Gly Met Pro Ala His Pro Ser Met Leu           
            320                 325                 330                   

ccc gtg agc cac aat gcc agc cca cct acc agc tcc agt cag tac ccc       1537
Pro Val Ser His Asn Ala Ser Pro Pro Thr Ser Ser Ser Gln Tyr Pro           
        335                 340                 345                       

agc ctg tgg tct gtg agc aac ggc gcc gtc acc ccg ggc tcc cag gca       1585
Ser Leu Trp Ser Val Ser Asn Gly Ala Val Thr Pro Gly Ser Gln Ala           
    350                 355                 360                           

gca gcc gtg tcc aac ggg ctg ggg gcc cag ttc ttc cgg ggc tcc ccc       1633
Ala Ala Val Ser Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser Pro           
365                 370                 375                 380           

gcg cac tac aca ccc ctc acc cat ccg gtc tcg gcg ccc tct tcc tcg       1681
Ala His Tyr Thr Pro Leu Thr His Pro Val Ser Ala Pro Ser Ser Ser           
                385                 390                 395               

gga tcc cca ctg tac gaa ggg gcg gcc gcg gcc aca gac atc gtg gac       1729
Gly Ser Pro Leu Tyr Glu Gly Ala Ala Ala Ala Thr Asp Ile Val Asp           
            400                 405                 410                   

agc cag tac gac gcc gca gcc caa ggc cgc ctc ata gcc tca tgg aca       1777
Ser Gln Tyr Asp Ala Ala Ala Gln Gly Arg Leu Ile Ala Ser Trp Thr           
        415                 420                 425                       

cct gtg tcg cca cct tcc atg tga agcagcaagg cccaggtccc gaaagatgca      1831
Pro Val Ser Pro Pro Ser Met                                               
    430                 435                                               

gtgacttttt gtcgtggcag ccagtggtga ctggattgac ctactaggta cccagtggca     1891

gtctcaggtt aagaaggaaa tgcagcctca gtaacttcct tttcaaagca gtggaggagc     1951

acacggcacc tttccccaga gccccagcat cccttgctca cacctgcagt agcggtgctg     2011

tcccaggtgg cttacagatg aacccaactg tggagatgat gcagttggcc caacctcact     2071

gacggtgaaa aaatgtttgc cagggtccag aaactttttt tggtttattt ctcatacagt     2131

gtattggcaa ctttggcaca ccagaatttg taaactccac cagtcctact ttagtgagat     2191

aaaaagcaca ctcttaatct tcttccttgt tgctttcaag tagttagagt tgagctgtta     2251

aggacagaat aaaatcatag ttgaggacag caggttttag ttgaattgaa aatttgactg     2311

ctctgccccc tagaatgtgt gtattttaag catatgtagc taatctcttg tgttgttaaa     2371

ctataactgt ttcatatttt tcttttgaca aagtagccaa agacaatcag cagaaagcat     2431

tttctgcaaa ataaacgcaa tatgcaaaat gtgattcgtc cagttattag tgaagcccct     2491

ccttttgtga gtatttactg tttattg                                         2518


<210>  15
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys Ser Leu Gln Tyr Arg 
1               5                   10                  15      


Val Asp His Leu Leu Ser Ala Val Glu Asn Glu Leu Gln Ala Gly Ser 
            20                  25                  30          


Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg Val Gly Leu Glu Glu 
        35                  40                  45              


Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr Asn Glu Met Ile Val 
    50                  55                  60                  


Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu Lys Val Asn Val Ser 
65                  70                  75                  80  


Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu Leu Asp Phe Val Ala 
                85                  90                  95      


Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly Glu Trp Val Pro Gly 
            100                 105                 110         


Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val Tyr Ile His Pro Asp 
        115                 120                 125             


Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala Pro Val Ser Phe Ser 
    130                 135                 140                 


Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly Gly Gln Ile Met Leu 
145                 150                 155                 160 


Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His Ile Val Arg Val Gly 
                165                 170                 175     


Gly Pro Gln Arg Met Ile Thr Ser His Cys Phe Pro Glu Thr Gln Phe 
            180                 185                 190         


Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile Thr Ala Leu Lys Ile 
        195                 200                 205             


Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp Ala Lys Glu Arg Ser 
    210                 215                 220                 


Asp His Lys Glu Met Met Glu Glu Pro Gly Asp Ser Gln Gln Pro Gly 
225                 230                 235                 240 


Tyr Ser Gln Trp Gly Trp Leu Leu Pro Gly Thr Ser Thr Leu Cys Pro 
                245                 250                 255     


Pro Ala Asn Pro His Pro Gln Phe Gly Gly Ala Leu Ser Leu Pro Ser 
            260                 265                 270         


Thr His Ser Cys Asp Arg Tyr Pro Thr Leu Arg Ser His Arg Ser Ser 
        275                 280                 285             


Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Asn Ser Pro Thr Tyr Ser 
    290                 295                 300                 


Asp Asn Ser Pro Ala Cys Leu Ser Met Leu Gln Ser His Asp Asn Trp 
305                 310                 315                 320 


Ser Ser Leu Gly Met Pro Ala His Pro Ser Met Leu Pro Val Ser His 
                325                 330                 335     


Asn Ala Ser Pro Pro Thr Ser Ser Ser Gln Tyr Pro Ser Leu Trp Ser 
            340                 345                 350         


Val Ser Asn Gly Ala Val Thr Pro Gly Ser Gln Ala Ala Ala Val Ser 
        355                 360                 365             


Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser Pro Ala His Tyr Thr 
    370                 375                 380                 


Pro Leu Thr His Pro Val Ser Ala Pro Ser Ser Ser Gly Ser Pro Leu 
385                 390                 395                 400 


Tyr Glu Gly Ala Ala Ala Ala Thr Asp Ile Val Asp Ser Gln Tyr Asp 
                405                 410                 415     


Ala Ala Ala Gln Gly Arg Leu Ile Ala Ser Trp Thr Pro Val Ser Pro 
            420                 425                 430         


Pro Ser Met 
        435 


