                         SEQUENCE LISTING

<110>  Lpath, Inc.
       Sabbadini, Roger
 
<120>  HUMANIZED ANTIBODY COMPOSITIONS AND METHODS FOR BINDING 
       LYSOPHOSPHATIDIC ACID

<130>  LPT-3210-PC

<140>  PCT/US10/31339
<141>  2010-04-16

<150>  US 61/170,595
<151>  2009-04-17

<160>  189   

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  1
atgaaatgca gctggggcat sttcttc                                           27


<210>  2
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  2
atgggatgga gctrtatcat sytctt                                            26


<210>  3
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  3
atgaagwtgt ggttaaactg ggttttt                                           27


<210>  4
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  4
atgractttg ggytcagctt grttt                                             25


<210>  5
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  5
atggactcca ggctcaattt agttttcctt                                        30


<210>  6
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  6
atggctgtcy trgsgctrct cttctgc                                           27


<210>  7
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  7
atggratgga gckggrtctt tmtctt                                            26


<210>  8
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  8
atgagagtgc tgattctttt gtg                                               23


<210>  9
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  9
atggmttggg tgtggamctt gctattcctg                                        30


<210>  10
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  10
atgggcagac ttacattctc attcctg                                           27


<210>  11
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  11
atggattttg ggctgatttt ttttattg                                          28


<210>  12
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  12
atgatggtgt taagtcttct gtacctg                                           27


<210>  13
<211>  35
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  13
atatccacca tggratgsag ctgkgtmats ctctt                                  35


<210>  14
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  14
cagtggatag acagatgggg g                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  15
cagtggatag accgatgggg c                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  16
cagtggatag actgatgggg g                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  17
caagggatag acagatgggg c                                                 21


<210>  18
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  18
ggcagcacta gtaggggcca gtggata                                           27


<210>  19
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  19
gggcaccatg gagacagaca cactcctgct at                                     32


<210>  20
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  20
gggcaccatg gattttcaag tgcagatttt cag                                    33


<210>  21
<211>  34
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  21
gggcaccatg gagwcacakw ctcaggtctt trta                                   34


<210>  22
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  22
gggcaccatg kccccwrctc agytyctkgt                                        30


<210>  23
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  23
caccatgaag ttgcctgtta ggctgttg                                          28


<210>  24
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  24
atgaagttgv vtgttaggct gttggtgctg                                        30


<210>  25
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  25
atggagwcag acacactcct gytatgggtg                                        30


<210>  26
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  26
atgagtgtgc tcactcaggt cctggsgttg                                        30


<210>  27
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  27
atgaggrccc ctgctcagwt tyttggmwtc ttg                                    33


<210>  28
<211>  29
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  28
atggatttwa ggtgcagatt wtcagcttc                                         29


<210>  29
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  29
atgaggtkck ktgktsagst sctgrgg                                           27


<210>  30
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  30
atgggcwtca agatggagtc acakwyycwg g                                      31


<210>  31
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  31
atgtggggay ctktttycmm tttttcaatt g                                      31


<210>  32
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  32
atggtrtccw casctcagtt ccttg                                             25


<210>  33
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  33
atgtatatat gtttgttgtc tatttct                                           27


<210>  34
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  34
atggaagccc cagctcagct tctcttcc                                          28


<210>  35
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  35
tgggtatctg gtrcstgtg                                                    19


<210>  36
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  36
atggagwcag acacactsct g                                                 21


<210>  37
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  37
atgragtywc agacccaggt cttyrt                                            26


<210>  38
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  38
atggagacac attctcaggt ctttgt                                            26


<210>  39
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  39
atggattcac aggcccaggt tcttat                                            26


<210>  40
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  40
atgatgagtc ctgcccagtt cctctt                                            26


<210>  41
<211>  29
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  41
atgaatttgc ctgttcatct cttggtgct                                         29


<210>  42
<211>  29
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  42
atggattttc aattggtcct catctcctt                                         29


<210>  43
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  43
atgaggtgcc tarctsagtt cctgrg                                            26


<210>  44
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  44
atgaagtact ctgctcagtt tctagg                                            26


<210>  45
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  45
atgaggcatt ctcttcaatt cttggg                                            26


<210>  46
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  46
actggatggt gggaagatgg                                                   20


<210>  47
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  47
gaagatctag acttactatg cagcatcagc                                        30


<210>  48
<211>  60
<212>  DNA
<213>  artificial

<220>
<223>  leader

<400>  48
atgtctgtgc ctacccaggt gctgggactg ctgctgctgt ggctgacaga cgcccgctgt       60


<210>  49
<211>  57
<212>  DNA
<213>  artificial

<220>
<223>  leader

<400>  49
atggaatgga gctgggtgtt cctgttcttt ctgtccgtga ccacaggcgt gcattct          57


<210>  50
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  50
ggagacgcct tcacaaatta cttaatagag                                        30


<210>  51
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  51
ctgatttatc ctgatagtgg ttacattaac tacaatgaga acttcaaggg c                51


<210>  52
<211>  39
<212>  DNA
<213>  Mus musculus

<400>  52
agatttgctt actacggtag tggctactac tttgactac                              39


<210>  53
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  53
agatctagtc agagccttct aaaaactaat ggaaacacct atttacat                    48


<210>  54
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  54
aaagtttcca accgattttc t                                                 21


<210>  55
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  55
tctcaaagta cacattttcc attcacg                                           27


<210>  56
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  56

Gly Asp Ala Phe Thr Asn Tyr Leu Ile Glu 
1               5                   10  


<210>  57
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  57

Leu Ile Tyr Pro Asp Ser Gly Tyr Ile Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  58

Arg Phe Ala Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  59
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  59

Arg Ser Ser Gln Ser Leu Leu Lys Thr Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  60
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  60

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  61

Ser Gln Ser Thr His Phe Pro Phe Thr 
1               5                   


<210>  62
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  62

Asn Tyr Leu Ile Glu 
1               5   


<210>  63
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  63
ggatacggct tcattaatta cttaatagag                                        30


<210>  64
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  64
ctgattaatc ctggaagtga ttatactaac tacaatgaga acttcaaggg c                51


<210>  65
<211>  39
<212>  DNA
<213>  Mus musculus

<400>  65
agatttggtt actacggtag cggcaactac tttgactac                              39


<210>  66
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  66
acatctggtc agagccttgt ccacattaat ggaaacacct atttacat                    48


<210>  67
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  67
aaagtttcca acctattttc t                                                 21


<210>  68
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  68
tctcaaagta cacattttcc attcacg                                           27


<210>  69
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  69

Gly Tyr Gly Phe Ile Asn Tyr Leu Ile Glu 
1               5                   10  


<210>  70
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  70

Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  71
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  71

Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr 
1               5                   10              


<210>  72
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  72

Thr Ser Gly Gln Ser Leu Val His Ile Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  73
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  73

Lys Val Ser Asn Leu Phe Ser 
1               5           


<210>  74
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  74

Ser Gln Ser Thr His Phe Pro Phe Thr 
1               5                   


<210>  75
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  75
ggagacgcct tcactaatta cttgatcgag                                        30


<210>  76
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  76
ctgattattc ctggaactgg ttatactaac tacaatgaga acttcaaggg c                51


<210>  77
<211>  39
<212>  DNA
<213>  Mus musculus

<400>  77
agatttggtt actacggtag tagcaactac tttgactac                              39


<210>  78
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  78
agatctagtc agagccttgt acacagtaat ggaaacacct atttacat                    48


<210>  79
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  79
aaagtttcca accgattttc t                                                 21


<210>  80
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  80
tctcaaagta cacattttcc attcact                                           27


<210>  81
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  81

Gly Asp Ala Phe Thr Asn Tyr Leu Ile Glu 
1               5                   10  


<210>  82
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  82

Leu Ile Ile Pro Gly Thr Gly Tyr Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  83

Arg Phe Gly Tyr Tyr Gly Ser Ser Asn Tyr Phe Asp Tyr 
1               5                   10              


<210>  84
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  84

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  85
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  85

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  86
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  86

Ser Gln Ser Thr His Phe Pro Phe Thr 
1               5                   


<210>  87
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  87
ggagacgcct tcactaatta cttgatcgag                                        30


<210>  88
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  88
ctgattattc ctggaactgg ttatactaac tacaatgaga acttcaaggg c                51


<210>  89
<211>  39
<212>  DNA
<213>  Mus musculus

<400>  89
agatttggtt actacggtag tggctactac tttgactac                              39


<210>  90
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  90
agatctagtc agagccttgt acacagtaat ggaaacacct atttacat                    48


<210>  91
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  91
aaagtttcca accgattttc t                                                 21


<210>  92
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  92
tctcaaagta cacattttcc attcacg                                           27


<210>  93
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  93

Gly Asp Ala Phe Thr Asn Tyr Leu Ile Glu 
1               5                   10  


<210>  94
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  94

Leu Ile Ile Pro Gly Thr Gly Tyr Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  95

Arg Phe Gly Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  96
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  96

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  97
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  97

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  98
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  98

Ser Gln Ser Thr His Phe Pro Phe Thr 
1               5                   


<210>  99
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  99
ggcttctcca tcaccagtgg ttattactgg acc                                    33


<210>  100
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  100
tacataggct acgatggtag caatgactcc aacccatctc tcaaaaat                    48


<210>  101
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  101
gcgatgttgc ggcgaggatt tgactac                                           27


<210>  102
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  102
agtgccagct caagtttaag ttacatgcac                                        30


<210>  103
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  103
gacacatcca aactggcttc t                                                 21


<210>  104
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  104
catcggcgga gtagttacac g                                                 21


<210>  105
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  105

Gly Phe Ser Ile Thr Ser Gly Tyr Tyr Trp Thr 
1               5                   10      


<210>  106
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  106

Tyr Ile Gly Tyr Asp Gly Ser Asn Asp Ser Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  107
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  107

Ala Met Leu Arg Arg Gly Phe Asp Tyr 
1               5                   


<210>  108
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  108

Ser Ala Ser Ser Ser Leu Ser Tyr Met His 
1               5                   10  


<210>  109
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  109

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  110
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  110

His Arg Arg Ser Ser Tyr Thr 
1               5           


<210>  111
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  111

Ser Gly Tyr Tyr Trp Thr 
1               5       


<210>  112
<211>  455
<212>  DNA
<213>  Mus musculus

<400>  112
aagcttgccg ccaccatgga atggagctgg gtgttcctgt tctttctgtc cgtgaccaca       60

ggcgtgcatt ctcaggtcaa gctgcagcag tctggacctg agctggtaag gcctgggact      120

tcagtgaagg tgtcctgcac ggcttctgga gacgccttca caaattactt aatagagtgg      180

gtaaaacaga ggcctggaca gggccttgag tggattggac tgatttatcc tgatagtggt      240

tacattaact acaatgagaa cttcaagggc aaggcaacac tgactgcaga cagatcctcc      300

agcactgcct acatgcagct cagcagcctg acatctgagg actctgcggt ctatttctgt      360

gcaagaagat ttgcttacta cggtagtggc tactactttg actactgggg ccaaggcacc      420

actctcacag tctcctcagc ctccaccaag ggccc                                 455


<210>  113
<211>  417
<212>  DNA
<213>  Mus musculus

<400>  113
aagcttgccg ccaccatgtc tgtgcctacc caggtgctgg gactgctgct gctgtggctg       60

acagacgccc gctgtgatgt tgtgatgacc caaactccac tctccctgcc tgtcagtctt      120

ggagatcaag cctccatctc ttgcagatct agtcagagcc ttctaaaaac taatggaaac      180

acctatttac attggtacct gcagaagcca ggccagtctc caaaactcct aatcttcaaa      240

gtttccaacc gattttctgg ggtcccggac aggttcagtg gcagtggatc agggacagac      300

ttcacactca agatcagcag agtggaggct gaggatctgg gagtttattt ctgctctcaa      360

agtacacatt ttccattcac gttcggcacg gggacaaaat tggaaataaa acgtacg         417


<210>  114
<211>  151
<212>  PRT
<213>  Mus musculus

<400>  114

Lys Leu Ala Ala Thr Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu 
1               5                   10                  15      


Ser Val Thr Thr Gly Val His Ser Gln Val Lys Leu Gln Gln Ser Gly 
            20                  25                  30          


Pro Glu Leu Val Arg Pro Gly Thr Ser Val Lys Val Ser Cys Thr Ala 
        35                  40                  45              


Ser Gly Asp Ala Phe Thr Asn Tyr Leu Ile Glu Trp Val Lys Gln Arg 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Ile Gly Leu Ile Tyr Pro Asp Ser Gly 
65                  70                  75                  80  


Tyr Ile Asn Tyr Asn Glu Asn Phe Lys Gly Lys Ala Thr Leu Thr Ala 
                85                  90                  95      


Asp Arg Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
            100                 105                 110         


Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg Phe Ala Tyr Tyr Gly 
        115                 120                 125             


Ser Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly 
145                 150     


<210>  115
<211>  139
<212>  PRT
<213>  Mus musculus

<400>  115

Lys Leu Ala Ala Thr Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu 
1               5                   10                  15      


Leu Leu Trp Leu Thr Asp Ala Arg Cys Asp Val Val Met Thr Gln Thr 
            20                  25                  30          


Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys 
        35                  40                  45              


Arg Ser Ser Gln Ser Leu Leu Lys Thr Asn Gly Asn Thr Tyr Leu His 
    50                  55                  60                  


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Phe Lys 
65                  70                  75                  80  


Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
                85                  90                  95      


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
            100                 105                 110         


Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Phe Pro Phe Thr Phe 
        115                 120                 125             


Gly Thr Gly Thr Lys Leu Glu Ile Lys Arg Thr 
    130                 135                 


<210>  116
<211>  455
<212>  DNA
<213>  Mus musculus

<400>  116
aagcttgccg ccaccatgga atggagctgg gtgttcctgt tctttctgtc cgtgaccaca       60

ggcgtgcatt ctcaggtcca actgcagcag tctggagctg agctggtaag gcctgggact      120

tcagtgaagg tgtcctgcaa ggcttctgga tacggcttca ttaattactt aatagagtgg      180

ataaaacaga ggcctggaca gggccttgag tggattggac tgattaatcc tggaagtgat      240

tatactaact acaatgagaa cttcaagggc aaggcaacac tgactgcaga caagtcctcc      300

agcactgcct acatgcacct cagcagcctg acatctgagg actctgcggt ctatttctgt      360

gcaagaagat ttggttacta cggtagcggc aactactttg actactgggg ccaaggcacc      420

actctcacag tctcctcagc ctccaccaag ggccc                                 455


<210>  117
<211>  417
<212>  DNA
<213>  Mus musculus

<400>  117
aagcttgccg ccaccatgtc tgtgcctacc caggtgctgg gactgctgct gctgtggctg       60

acagacgccc gctgtgatgt tgtgatgacc caaactccac tctccctgcc tgtcagtctt      120

ggagatcaag cctccatctc ttgcacatct ggtcagagcc ttgtccacat taatggaaac      180

acctatttac attggtacct gcagaagcca ggccagtctc caaagctcct catctacaaa      240

gtttccaacc tattttctgg ggtcccagac aggttcagtg gcagtggatc agggacagat      300

ttcacactca agatcagcag agtggaggct gaggatctgg gagtttattt ctgctctcaa      360

agtacacatt ttccattcac gttcggcacg gggacaaaat tggaaataaa acgtacg         417


<210>  118
<211>  151
<212>  PRT
<213>  Mus musculus

<400>  118

Lys Leu Ala Ala Thr Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu 
1               5                   10                  15      


Ser Val Thr Thr Gly Val His Ser Gln Val Gln Leu Gln Gln Ser Gly 
            20                  25                  30          


Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Gly Phe Ile Asn Tyr Leu Ile Glu Trp Ile Lys Gln Arg 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Ile Gly Leu Ile Asn Pro Gly Ser Asp 
65                  70                  75                  80  


Tyr Thr Asn Tyr Asn Glu Asn Phe Lys Gly Lys Ala Thr Leu Thr Ala 
                85                  90                  95      


Asp Lys Ser Ser Ser Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser 
            100                 105                 110         


Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg Phe Gly Tyr Tyr Gly 
        115                 120                 125             


Ser Gly Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly 
145                 150     


<210>  119
<211>  139
<212>  PRT
<213>  Mus musculus

<400>  119

Lys Leu Ala Ala Thr Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu 
1               5                   10                  15      


Leu Leu Trp Leu Thr Asp Ala Arg Cys Asp Val Val Met Thr Gln Thr 
            20                  25                  30          


Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys 
        35                  40                  45              


Thr Ser Gly Gln Ser Leu Val His Ile Asn Gly Asn Thr Tyr Leu His 
    50                  55                  60                  


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys 
65                  70                  75                  80  


Val Ser Asn Leu Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
                85                  90                  95      


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
            100                 105                 110         


Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Phe Pro Phe Thr Phe 
        115                 120                 125             


Gly Thr Gly Thr Lys Leu Glu Ile Lys Arg Thr 
    130                 135                 


<210>  120
<211>  455
<212>  DNA
<213>  Mus musculus

<400>  120
aagcttgccg ccaccatgga atggagctgg gtgttcctgt tctttctgtc cgtgaccaca       60

ggcgtgcatt ctcaggtcca gctgcagcag tctggagctg agctggtcag gcctgggact      120

tcagtgaagg tgtcctgcaa ggcttctgga gacgccttca ctaattactt gatcgagtgg      180

gtaaagcaga ggcctggaca gggccttgag tggattggac tgattattcc tggaactggt      240

tatactaact acaatgagaa cttcaagggc aaggcaacac tgactgcaga caaatcctcc      300

agcactgcct acatgcagct cagcagcctg acatctgagg actctgcggt ctatttctgt      360

gcaagaagat ttggttacta cggtagtagc aactactttg actactgggg ccaaggcacc      420

actctcacag tctcctcagc ctccaccaag ggccc                                 455


<210>  121
<211>  417
<212>  DNA
<213>  Mus musculus

<400>  121
aagcttgccg ccaccatgtc tgtgcctacc caggtgctgg gactgctgct gctgtggctg       60

acagacgccc gctgtgatgt tgtgatgacc caaactccac tctccctgcc tgtcagtctt      120

ggagatcaag cctccatctc ttgcagatct agtcagagcc ttgtacacag taatggaaac      180

acctatttac attggtacct gcagaagcca ggccagtctc caaagctcct gatctacaaa      240

gtttccaacc gattttctgg ggtcccagac aggttcagtg gcagtggacc agggacagat      300

ttcacactca agatcagcag agtggaggct gaggatctgg gaatttattt ctgctctcaa      360

agtacacatt ttccattcac tttcggcacg gggacaaaat tggaaataaa acgtacg         417


<210>  122
<211>  151
<212>  PRT
<213>  Mus musculus

<400>  122

Lys Leu Ala Ala Thr Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu 
1               5                   10                  15      


Ser Val Thr Thr Gly Val His Ser Gln Val Gln Leu Gln Gln Ser Gly 
            20                  25                  30          


Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Asp Ala Phe Thr Asn Tyr Leu Ile Glu Trp Val Lys Gln Arg 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Ile Gly Leu Ile Ile Pro Gly Thr Gly 
65                  70                  75                  80  


Tyr Thr Asn Tyr Asn Glu Asn Phe Lys Gly Lys Ala Thr Leu Thr Ala 
                85                  90                  95      


Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
            100                 105                 110         


Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg Phe Gly Tyr Tyr Gly 
        115                 120                 125             


Ser Ser Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly 
145                 150     


<210>  123
<211>  139
<212>  PRT
<213>  Mus musculus

<400>  123

Lys Leu Ala Ala Thr Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu 
1               5                   10                  15      


Leu Leu Trp Leu Thr Asp Ala Arg Cys Asp Val Val Met Thr Gln Thr 
            20                  25                  30          


Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys 
        35                  40                  45              


Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
    50                  55                  60                  


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys 
65                  70                  75                  80  


Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
                85                  90                  95      


Pro Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
            100                 105                 110         


Leu Gly Ile Tyr Phe Cys Ser Gln Ser Thr His Phe Pro Phe Thr Phe 
        115                 120                 125             


Gly Thr Gly Thr Lys Leu Glu Ile Lys Arg Thr 
    130                 135                 


<210>  124
<211>  455
<212>  DNA
<213>  Mus musculus

<400>  124
aagcttgccg ccaccatgga atggagctgg gtgttcctgt tctttctgtc cgtgaccaca       60

ggcgtgcatt ctcaggtcca gctgcagcag tctggagctg agctggtcag gcctgggact      120

tcagtgaagt tgtcctgcaa ggcttctgga gacgccttca ctaattactt gatcgagtgg      180

gtaaagcaga ggcctggaca gggccttgag tggattggac tgattattcc tggaactggt      240

tatactaact acaatgagaa cttcaagggc aaggcaacac tgactgcaga caagtcctcc      300

agcactgcct acatgcagct cagcagcctg acatctgagg actctgcggt ctatttctgt      360

gcaagaagat ttggttacta cggtagtggc tactactttg actactgggg ccaaggcacc      420

actctcacag tctcctcagc ctccaccaag ggccc                                 455


<210>  125
<211>  417
<212>  DNA
<213>  Mus musculus

<400>  125
aagcttgccg ccaccatgtc tgtgcctacc caggtgctgg gactgctgct gctgtggctg       60

acagacgccc gctgtgatgt tgtgatgacc caaactccac tctccctgcc tgtcagtctt      120

ggagatcaag cctccatctc ttgcagatct agtcagagcc ttgtacacag taatggaaac      180

acctatttac attggtacct gcagaagcca ggccagtctc caaagctcct gatctacaaa      240

gtttccaacc gattttctgg ggtcccagac aggttcagtg gcagtggacc agggacagat      300

ttcacactca agatcagcag agtggaggct gaggatctgg gagtttattt ctgctctcaa      360

agtacacatt ttccattcac gttcggcacg ggcacaaaat tggaaataaa acgtacg         417


<210>  126
<211>  151
<212>  PRT
<213>  Mus musculus

<400>  126

Lys Leu Ala Ala Thr Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu 
1               5                   10                  15      


Ser Val Thr Thr Gly Val His Ser Gln Val Gln Leu Gln Gln Ser Gly 
            20                  25                  30          


Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Asp Ala Phe Thr Asn Tyr Leu Ile Glu Trp Val Lys Gln Arg 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Ile Gly Leu Ile Ile Pro Gly Thr Gly 
65                  70                  75                  80  


Tyr Thr Asn Tyr Asn Glu Asn Phe Lys Gly Lys Ala Thr Leu Thr Ala 
                85                  90                  95      


Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
            100                 105                 110         


Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg Phe Gly Tyr Tyr Gly 
        115                 120                 125             


Ser Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly 
145                 150     


<210>  127
<211>  139
<212>  PRT
<213>  Mus musculus

<400>  127

Lys Leu Ala Ala Thr Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu 
1               5                   10                  15      


Leu Leu Trp Leu Thr Asp Ala Arg Cys Asp Val Val Met Thr Gln Thr 
            20                  25                  30          


Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys 
        35                  40                  45              


Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
    50                  55                  60                  


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys 
65                  70                  75                  80  


Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
                85                  90                  95      


Pro Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
            100                 105                 110         


Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Phe Pro Phe Thr Phe 
        115                 120                 125             


Gly Thr Gly Thr Lys Leu Glu Ile Lys Arg Thr 
    130                 135                 


<210>  128
<211>  443
<212>  DNA
<213>  Mus musculus

<400>  128
aagcttgccg ccaccatgga atggagctgg gtgttcctgt tctttctgtc cgtgaccaca       60

ggcgtgcatt ctgatataca gcttcaggag tcaggacctg gcctcgtgaa accttctcag      120

tctctgtctc tcacctgctc tgtcactggc ttctccatca ccagtggtta ttactggacc      180

tggatccggc agtttccagg aaacaaactg gagtgggtgg cctacatagg ctacgatggt      240

agcaatgact ccaacccatc tctcaaaaat cgaatctcca tcacccgtga cacatctaag      300

aaccagtttt tcctgaagtt gaattctgtg actactgagg acacagccac atattactgt      360

gcaagagcga tgttgcggcg aggatttgac tactggggcc aaggcaccac tctcacagtc      420

tcctcagcct ccaccaaggg ccc                                              443


<210>  129
<211>  393
<212>  DNA
<213>  Mus musculus

<400>  129
aagcttgccg ccaccatgtc tgtgcctacc caggtgctgg gactgctgct gctgtggctg       60

acagacgccc gctgtcaaat tgttctcacc cagtctccag caatcatgtc tgcatctcca      120

ggggagaagg tcaccatgac ctgcagtgcc agctcaagtt taagttacat gcactggtac      180

cagcagaagc caggcacctc ccccaaaaga tggatttatg acacatccaa actggcttct      240

ggagtccctg ctcgcttcag tggcagtggg tctgggacct cttattctct cacaatcagc      300

agcatggagg ctgaagatgc tgccacttat tactgccatc ggcggagtag ttacacgttc      360

ggagggggga ccaagctgga aataaaacgt acg                                   393


<210>  130
<211>  147
<212>  PRT
<213>  Mus musculus

<400>  130

Lys Leu Ala Ala Thr Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu 
1               5                   10                  15      


Ser Val Thr Thr Gly Val His Ser Asp Ile Gln Leu Gln Glu Ser Gly 
            20                  25                  30          


Pro Gly Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val 
        35                  40                  45              


Thr Gly Phe Ser Ile Thr Ser Gly Tyr Tyr Trp Thr Trp Ile Arg Gln 
    50                  55                  60                  


Phe Pro Gly Asn Lys Leu Glu Trp Val Ala Tyr Ile Gly Tyr Asp Gly 
65                  70                  75                  80  


Ser Asn Asp Ser Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg 
                85                  90                  95      


Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Thr 
            100                 105                 110         


Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Ala Met Leu Arg Arg Gly 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly 
145         


<210>  131
<211>  131
<212>  PRT
<213>  Mus musculus

<400>  131

Lys Leu Ala Ala Thr Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu 
1               5                   10                  15      


Leu Leu Trp Leu Thr Asp Ala Arg Cys Gln Ile Val Leu Thr Gln Ser 
            20                  25                  30          


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
        35                  40                  45              


Ser Ala Ser Ser Ser Leu Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


His Arg Arg Ser Ser Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr 
    130     


<210>  132
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  132

Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Thr Ala Ser Gly Asp Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Tyr Pro Asp Ser Gly Tyr Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Ala Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  133
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  133

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Lys Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Phe Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Thr Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  134
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  134

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  135
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  135

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Thr Ser Gly Gln Ser Leu Val His Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Thr Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  136
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  136

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ile Pro Gly Thr Gly Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Ser Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  137
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  137

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Pro Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Thr Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  138
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  138

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Asp Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ile Pro Gly Thr Gly Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  139
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  139

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Pro Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Thr Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  140
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  140

Asp Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Phe Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Thr Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Val Ala Tyr Ile Gly Tyr Asp Gly Ser Asn Asp Ser Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Met Leu Arg Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  141
<211>  104
<212>  PRT
<213>  Mus musculus

<400>  141

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Leu Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Arg Arg Ser Ser Tyr Thr Phe Gly 
                85                  90                  95      


Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 


<210>  142
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  142
gaggtgcagc tggtgcagag cggagccgag gtgaagaagc ccggcgagag cctgaagatc       60

agctgccagg ccttcggcta cggcttcatc aactacctga tcgagtggat ccggcagatg      120

cccggccagg gcctggaatg gatcggcgca atcaaccccg gcagcgacta caccaactac      180

aacgagaact tcaagggcca ggccaccctg agcgccgaca agagcagcag caccgcctac      240

ctgcagtgga gcagcctgaa ggccagcgac accgccatgt acttttgcgc caggcggttc      300

ggctactacg gcagcggcaa ctacttcgac tactggggcc agggcaccat ggtgaccgtg      360

agcagc                                                                 366


<210>  143
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  143

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  144
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  144
gacgtggtga tgacccagac ccccctgagc ctgcccgtga ccccaggcga acccgccagc       60

atcagctgta gaagctccca gtccctgctg aaaaccaacg gcaacaccta tctgcactgg      120

tatctgcaga agcccggcca gagccccaag ctgctgatct acaaggtgtc caaccggttc      180

agcggcgtgc ccgacagatt cagcggcagc ggctccggca ccgacttcac cctgaagatc      240

agccgggtgg aggccgagga cgtgggcgtg tacttctgca gccagtccac ccacttccct      300

ttcaccttcg gccagggcac aaagctggaa atcaag                                336


<210>  145
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  145

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Lys Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  146
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  146
gacgtggtga tgacccagac ccccctgagc ctgcccgtga ccccaggcga acccgccagc       60

atcagctgta gaagctccca gtccctgctg aaaaccaacg gcaacaccta tctgcactgg      120

tatctgcaga agcccggcca gagcccccag ctgctgatct acaaggtgtc caaccggttc      180

agcggcgtgc ccgacagatt cagcggcagc ggctccggca ccgacttcac cctgaagatc      240

agccgggtgg aggccgagga cgtgggcgtg tactactgca gccagtccac ccacttccct      300

ttcaccttcg gccagggcac caagctggaa atcaag                                336


<210>  147
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  147

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Lys Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  148
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  148
gacgtggtga tgacccagac ccccctgagc ctgcccgtga ccccaggcga acccgccagc       60

atcagctgta gaagctccca gagcctgctg aaaaccaacg gcaacaccta tctgcactgg      120

tatctgcaga agcccggcca gagccccaag ctgctgattt tcaaggtgtc caaccggttc      180

agcggcgtgc ccgacagatt cagcggcagc ggctccggca ccgacttcac cctgaagatc      240

agccgggtgg aggccgagga cgtgggcgtg tacttctgca gccagtccac ccacttccct      300

ttcaccttcg gccagggcac aaagctggaa atcaag                                336


<210>  149
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  149

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Lys Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Phe Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  150
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  150
gaggtgcagc tggtgcagag cggagccgaa gtgaagaagc ccggcgagag cctgaagatc       60

agctgccagg ccttcggcta cggcttcatc aactacctga tcgagtggat ccggcagatg      120

cccggacagg gcctggaatg gatcggcctg atctaccccg acagcggcta catcaattac      180

aacgagaact tcaagggcca ggccaccctg agcgccgaca agagcagcag caccgcctat      240

ctgcagtgga gcagcctgaa ggccagcgac accgccatgt acttttgcgc caggcggttc      300

gcctactacg gcagcggcta ctacttcgac tactggggcc agggcacaat ggtgaccgtg      360

tctagc                                                                 366


<210>  151
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  151

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Tyr Pro Asp Ser Gly Tyr Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Ala Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  152
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  152
gaggtgcagc tggtgcagag cggcgctgaa gtgaagaagc ccggcgagag cctgaagatc       60

agctgccagg ccttcggcta cgccttcacc aactacctga tcgagtgggt gcgccagatg      120

cccggacagg gcctggaatg gatgggcctg atctaccccg acagcggcta catcaactac      180

aacgagaact tcaagggcca ggtgaccatc agcgccgaca agagcagcag caccgcctat      240

ctgcagtgga gcagcctgaa ggccagcgac accgccatgt acttttgcgc caggcggttc      300

gcctactacg gcagcggcta ctacttcgac tactggggcc agggcacaat ggtgaccgtg      360

tccagc                                                                 366


<210>  153
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  153

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Asp Ser Gly Tyr Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Ala Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  154
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  154
gaggtgcagc tggtgcagag cggcgctgaa gtgaagaagc ccggcgagag cctgaagatc       60

agctgccagg ccttcggcta cgccttcacc aactacctga tcgagtgggt gcgccagatg      120

cccggacagg gcctggaatg gatcggcctg atctaccccg acagcggcta catcaactac      180

aacgagaact tcaagggcca ggccaccctg agcgccgaca agagcagcag caccgcctat      240

ctgcagtgga gcagcctgaa ggccagcgac accgccatgt acttttgcgc caggcggttc      300

gcctactacg gcagcggcta ctacttcgac tactggggcc agggcacaat ggtgaccgtg      360

tccagc                                                                 366


<210>  155
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  155

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Tyr Pro Asp Ser Gly Tyr Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Ala Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  156
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  156
gaggtgcagc tggtgcagag cggagccgaa gtgaagaagc ccggcgagag cctgaagatc       60

agctgccagg ccttcggcga cgccttcacc aactacctga tcgagtgggt gcgccagatg      120

cccggacagg gcctggaatg gatgggcctg atctaccccg acagcggcta catcaactac      180

aacgagaact tcaagggcca ggtgaccatc agcgccgaca gaagcagcag caccgcctat      240

ctgcagtgga gcagcctgaa ggccagcgac accgccatgt acttttgcgc caggcggttc      300

gcctactacg gcagcggcta ctacttcgac tactggggcc agggcacaat ggtgaccgtg      360

tccagc                                                                 366


<210>  157
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  157

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Asp Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Asp Ser Gly Tyr Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Ala Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  158
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  158
gaggtgcagc tggtgcagag cggagccgaa gtgaagaagc ccggcgagag cctgaagatc       60

agctgccagg ccttcggcga cgccttcacc aactacctga tcgagtgggt gcgccagatg      120

cccggacagg gcctggaatg gatcggcctg atctaccccg acagcggcta catcaactac      180

aacgagaact tcaagggcca ggccaccctg agcgccgaca gaagcagcag caccgcctat      240

ctgcagtgga gcagcctgaa ggccagcgac accgccatgt acttttgcgc caggcggttc      300

gcctactacg gcagcggcta ctacttcgac tactggggcc agggcacaat ggtgaccgtg      360

tccagc                                                                 366


<210>  159
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  159

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Asp Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Tyr Pro Asp Ser Gly Tyr Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Ala Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  160
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  160

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Thr Ser Gly Gln Ser Leu Val His Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Thr Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  161
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  161

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Thr Ser Gly Gln Ser Leu Val His Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  162
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  162

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Thr Ser Gly Gln Ser Leu Val His Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  163
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  163

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Thr Ser Gly Gln Ser Leu Val His Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  164
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  164

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Thr Ser Gly Gln Ser Leu Val His Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  165
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  165

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Thr Ser Gly Gln Ser Leu Val His Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  166
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  166

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Thr Ser Gly Gln Ser Leu Val His Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  167
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  167

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Lys Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  168
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  168

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Lys Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  169
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  169

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Lys Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Phe Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  170
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  170

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  171
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  171

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ser Phe Gly Tyr Ile Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  172
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  172

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  173
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  173

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ser Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  174
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  174

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Ile Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  175
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  175

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  176
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  176

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  177
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  177

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  178
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  178

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Ile Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  179
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  179

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  180
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  180

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ser Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  181
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  181

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  182
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  182

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  183
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  183

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  184
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  184

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asn Pro Gly Ser Asp Tyr Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Gly Tyr Tyr Gly Ser Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  185
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  185

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Gly Phe Ile Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Tyr Pro Asp Ser Gly Tyr Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Ala Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  186
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  186

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Asp Ser Gly Tyr Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Ala Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  187
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  187

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Tyr Pro Asp Ser Gly Tyr Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Ala Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  188
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  188

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Asp Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Asp Ser Gly Tyr Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Ala Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  189
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  humanized antibody variant

<400>  189

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ala Phe Gly Asp Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Tyr Pro Asp Ser Gly Tyr Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Phe Ala Tyr Tyr Gly Ser Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


