                         SEQUENCE LISTING

<110>  Vereniging voor Christelijk Hoger Onderwijs, 
       Wetenschappelijk Onderzoek en Patientenzorg
 
<120>  Protein-based methods and compositions for the diagnosis of 
       colorectal adenocarcinoma

<130>  PH012911WO1

<150>  EP 09157464.0
<151>  2009-04-07

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  1896
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Leu Pro Pro Arg Ser Leu Gln Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Gly Met Trp Ala Glu Ala Gly Leu Pro Arg 
            20                  25                  30          


Ala Gly Gly Gly Ser Gln Pro Pro Phe Arg Thr Phe Ser Ala Ser Asp 
        35                  40                  45              


Trp Gly Leu Thr His Leu Val Val His Glu Gln Thr Gly Glu Val Tyr 
    50                  55                  60                  


Val Gly Ala Val Asn Arg Ile Tyr Lys Leu Ser Gly Asn Leu Thr Leu 
65                  70                  75                  80  


Leu Arg Ala His Val Thr Gly Pro Val Glu Asp Asn Glu Lys Cys Tyr 
                85                  90                  95      


Pro Pro Pro Ser Val Gln Ser Cys Pro His Gly Leu Gly Ser Thr Asp 
            100                 105                 110         


Asn Val Asn Lys Leu Leu Leu Leu Asp Tyr Ala Ala Asn Arg Leu Leu 
        115                 120                 125             


Ala Cys Gly Ser Ala Ser Gln Gly Ile Cys Gln Phe Leu Arg Leu Asp 
    130                 135                 140                 


Asp Leu Phe Lys Leu Gly Glu Pro His His Arg Lys Glu His Tyr Leu 
145                 150                 155                 160 


Ser Ser Val Gln Glu Ala Gly Ser Met Ala Gly Val Leu Ile Ala Gly 
                165                 170                 175     


Pro Pro Gly Gln Gly Gln Ala Lys Leu Phe Val Gly Thr Pro Ile Asp 
            180                 185                 190         


Gly Lys Ser Glu Tyr Phe Pro Thr Leu Ser Ser Arg Arg Leu Met Ala 
        195                 200                 205             


Asn Glu Glu Asp Ala Asp Met Phe Gly Phe Val Tyr Gln Asp Glu Phe 
    210                 215                 220                 


Val Ser Ser Gln Leu Lys Ile Pro Ser Asp Thr Leu Ser Lys Phe Pro 
225                 230                 235                 240 


Ala Phe Asp Ile Tyr Tyr Val Tyr Ser Phe Arg Ser Glu Gln Phe Val 
                245                 250                 255     


Tyr Tyr Leu Thr Leu Gln Leu Asp Thr Gln Leu Thr Ser Pro Asp Ala 
            260                 265                 270         


Ala Gly Glu His Phe Phe Thr Ser Lys Ile Val Arg Leu Cys Val Asp 
        275                 280                 285             


Asp Pro Lys Phe Tyr Ser Tyr Val Glu Phe Pro Ile Gly Cys Glu Gln 
    290                 295                 300                 


Ala Gly Val Glu Tyr Arg Leu Val Gln Asp Ala Tyr Leu Ser Arg Pro 
305                 310                 315                 320 


Gly Arg Ala Leu Ala His Gln Leu Gly Leu Ala Glu Asp Glu Asp Val 
                325                 330                 335     


Leu Phe Thr Val Phe Ala Gln Gly Gln Lys Asn Arg Val Lys Pro Pro 
            340                 345                 350         


Lys Glu Ser Ala Leu Cys Leu Phe Thr Leu Arg Ala Ile Lys Glu Lys 
        355                 360                 365             


Ile Lys Glu Arg Ile Gln Ser Cys Tyr Arg Gly Glu Gly Lys Leu Ser 
    370                 375                 380                 


Leu Pro Trp Leu Leu Asn Lys Glu Leu Gly Cys Ile Asn Ser Pro Leu 
385                 390                 395                 400 


Gln Ile Asp Asp Asp Phe Cys Gly Gln Asp Phe Asn Gln Pro Leu Gly 
                405                 410                 415     


Gly Thr Val Thr Ile Glu Gly Thr Pro Leu Phe Val Asp Lys Asp Asp 
            420                 425                 430         


Gly Leu Thr Ala Val Ala Ala Tyr Asp Tyr Arg Gly Arg Thr Val Val 
        435                 440                 445             


Phe Ala Gly Thr Arg Ser Gly Arg Ile Arg Lys Ile Leu Val Asp Leu 
    450                 455                 460                 


Ser Asn Pro Gly Gly Arg Pro Ala Leu Ala Tyr Glu Ser Val Val Ala 
465                 470                 475                 480 


Gln Glu Gly Ser Pro Ile Leu Arg Asp Leu Val Leu Ser Pro Asn His 
                485                 490                 495     


Gln Tyr Leu Tyr Ala Met Thr Glu Lys Gln Val Thr Arg Val Pro Val 
            500                 505                 510         


Glu Ser Cys Val Gln Tyr Thr Ser Cys Glu Leu Cys Leu Gly Ser Arg 
        515                 520                 525             


Asp Pro His Cys Gly Trp Cys Val Leu His Ser Ile Cys Ser Arg Arg 
    530                 535                 540                 


Asp Ala Cys Glu Arg Ala Asp Glu Pro Gln Arg Phe Ala Ala Asp Leu 
545                 550                 555                 560 


Leu Gln Cys Val Gln Leu Thr Val Gln Pro Arg Asn Val Ser Val Thr 
                565                 570                 575     


Met Ser Gln Val Pro Leu Val Leu Gln Ala Trp Asn Val Pro Asp Leu 
            580                 585                 590         


Ser Ala Gly Val Asn Cys Ser Phe Glu Asp Phe Thr Glu Ser Glu Ser 
        595                 600                 605             


Val Leu Glu Asp Gly Arg Ile His Cys Arg Ser Pro Ser Ala Arg Glu 
    610                 615                 620                 


Val Ala Pro Ile Thr Arg Gly Gln Gly Asp Gln Arg Val Val Lys Leu 
625                 630                 635                 640 


Tyr Leu Lys Ser Lys Glu Thr Gly Lys Lys Phe Ala Ser Val Asp Phe 
                645                 650                 655     


Val Phe Tyr Asn Cys Ser Val His Gln Ser Cys Leu Ser Cys Val Asn 
            660                 665                 670         


Gly Ser Phe Pro Cys His Trp Cys Lys Tyr Arg His Val Cys Thr His 
        675                 680                 685             


Asn Val Ala Asp Cys Ala Phe Leu Glu Gly Arg Val Asn Val Ser Glu 
    690                 695                 700                 


Asp Cys Pro Gln Ile Leu Pro Ser Thr Gln Ile Tyr Val Pro Val Gly 
705                 710                 715                 720 


Val Val Lys Pro Ile Thr Leu Ala Ala Arg Asn Leu Pro Gln Pro Gln 
                725                 730                 735     


Ser Gly Gln Arg Gly Tyr Glu Cys Leu Phe His Ile Pro Gly Ser Pro 
            740                 745                 750         


Ala Arg Val Thr Ala Leu Arg Phe Asn Ser Ser Ser Leu Gln Cys Gln 
        755                 760                 765             


Asn Ser Ser Tyr Ser Tyr Glu Gly Asn Asp Val Ser Asp Leu Pro Val 
    770                 775                 780                 


Asn Leu Ser Val Val Trp Asn Gly Asn Phe Val Ile Asp Asn Pro Gln 
785                 790                 795                 800 


Asn Ile Gln Ala His Leu Tyr Lys Cys Pro Ala Leu Arg Glu Ser Cys 
                805                 810                 815     


Gly Leu Cys Leu Lys Ala Asp Pro Arg Phe Glu Cys Gly Trp Cys Val 
            820                 825                 830         


Ala Glu Arg Arg Cys Ser Leu Arg His His Cys Ala Ala Asp Thr Pro 
        835                 840                 845             


Ala Ser Trp Met His Ala Arg His Gly Ser Ser Arg Cys Thr Asp Pro 
    850                 855                 860                 


Lys Ile Leu Lys Leu Ser Pro Glu Thr Gly Pro Arg Gln Gly Gly Thr 
865                 870                 875                 880 


Arg Leu Thr Ile Thr Gly Glu Asn Leu Gly Leu Arg Phe Glu Asp Val 
                885                 890                 895     


Arg Leu Gly Val Arg Val Gly Lys Val Leu Cys Ser Pro Val Glu Ser 
            900                 905                 910         


Glu Tyr Ile Ser Ala Glu Gln Ile Val Cys Glu Ile Gly Asp Ala Ser 
        915                 920                 925             


Ser Val Arg Ala His Asp Ala Leu Val Glu Val Cys Val Arg Asp Cys 
    930                 935                 940                 


Ser Pro His Tyr Arg Ala Leu Ser Pro Lys Arg Phe Thr Phe Val Thr 
945                 950                 955                 960 


Pro Thr Phe Tyr Arg Val Ser Pro Ser Arg Gly Pro Leu Ser Gly Gly 
                965                 970                 975     


Thr Trp Ile Gly Ile Glu Gly Ser His Leu Asn Ala Gly Ser Asp Val 
            980                 985                 990         


Ala Val Ser Val Gly Gly Arg Pro  Cys Ser Phe Ser Trp  Arg Asn Ser 
        995                 1000                 1005             


Arg Glu  Ile Arg Cys Leu Thr  Pro Pro Gly Gln Ser  Pro Gly Ser 
    1010                 1015                 1020             


Ala Pro  Ile Ile Ile Asn Ile  Asn Arg Ala Gln Leu  Thr Asn Pro 
    1025                 1030                 1035             


Glu Val  Lys Tyr Asn Tyr Thr  Glu Asp Pro Thr Ile  Leu Arg Ile 
    1040                 1045                 1050             


Asp Pro  Glu Trp Ser Ile Asn  Ser Gly Gly Thr Leu  Leu Thr Val 
    1055                 1060                 1065             


Thr Gly  Thr Asn Leu Ala Thr  Val Arg Glu Pro Arg  Ile Arg Ala 
    1070                 1075                 1080             


Lys Tyr  Gly Gly Ile Glu Arg  Glu Asn Gly Cys Leu  Val Tyr Asn 
    1085                 1090                 1095             


Asp Thr  Thr Met Val Cys Arg  Ala Pro Ser Val Ala  Asn Pro Val 
    1100                 1105                 1110             


Arg Ser  Pro Pro Glu Leu Gly  Glu Arg Pro Asp Glu  Leu Gly Phe 
    1115                 1120                 1125             


Val Met  Asp Asn Val Arg Ser  Leu Leu Val Leu Asn  Ser Thr Ser 
    1130                 1135                 1140             


Phe Leu  Tyr Tyr Pro Asp Pro  Val Leu Glu Pro Leu  Ser Pro Thr 
    1145                 1150                 1155             


Gly Leu  Leu Glu Leu Lys Pro  Ser Ser Pro Leu Ile  Leu Lys Gly 
    1160                 1165                 1170             


Arg Asn  Leu Leu Pro Pro Ala  Pro Gly Asn Ser Arg  Leu Asn Tyr 
    1175                 1180                 1185             


Thr Val  Leu Ile Gly Ser Thr  Pro Cys Thr Leu Thr  Val Ser Glu 
    1190                 1195                 1200             


Thr Gln  Leu Leu Cys Glu Ala  Pro Asn Leu Thr Gly  Gln His Lys 
    1205                 1210                 1215             


Val Thr  Val Arg Ala Gly Gly  Phe Glu Phe Ser Pro  Gly Thr Leu 
    1220                 1225                 1230             


Gln Val  Tyr Ser Asp Ser Leu  Leu Thr Leu Pro Ala  Ile Val Gly 
    1235                 1240                 1245             


Ile Gly  Gly Gly Gly Gly Leu  Leu Leu Leu Val Ile  Val Ala Val 
    1250                 1255                 1260             


Leu Ile  Ala Tyr Lys Arg Lys  Ser Arg Asp Ala Asp  Arg Thr Leu 
    1265                 1270                 1275             


Lys Arg  Leu Gln Leu Gln Met  Asp Asn Leu Glu Ser  Arg Val Ala 
    1280                 1285                 1290             


Leu Glu  Cys Lys Glu Ala Phe  Ala Glu Leu Gln Thr  Asp Ile His 
    1295                 1300                 1305             


Glu Leu  Thr Asn Asp Leu Asp  Gly Ala Gly Ile Pro  Phe Leu Asp 
    1310                 1315                 1320             


Tyr Arg  Thr Tyr Ala Met Arg  Val Leu Phe Pro Gly  Ile Glu Asp 
    1325                 1330                 1335             


His Pro  Val Leu Lys Glu Met  Glu Val Gln Ala Asn  Val Glu Lys 
    1340                 1345                 1350             


Ser Leu  Thr Leu Phe Gly Gln  Leu Leu Thr Lys Lys  His Phe Leu 
    1355                 1360                 1365             


Leu Thr  Phe Ile Arg Thr Leu  Glu Ala Gln Arg Ser  Phe Ser Met 
    1370                 1375                 1380             


Arg Asp  Arg Gly Asn Val Ala  Ser Leu Ile Met Thr  Ala Leu Gln 
    1385                 1390                 1395             


Gly Glu  Met Glu Tyr Ala Thr  Gly Val Leu Lys Gln  Leu Leu Ser 
    1400                 1405                 1410             


Asp Leu  Ile Glu Lys Asn Leu  Glu Ser Lys Asn His  Pro Lys Leu 
    1415                 1420                 1425             


Leu Leu  Arg Arg Thr Glu Ser  Val Ala Glu Lys Met  Leu Thr Asn 
    1430                 1435                 1440             


Trp Phe  Thr Phe Leu Leu Tyr  Lys Phe Leu Lys Glu  Cys Ala Gly 
    1445                 1450                 1455             


Glu Pro  Leu Phe Met Leu Tyr  Cys Ala Ile Lys Gln  Gln Met Glu 
    1460                 1465                 1470             


Lys Gly  Pro Ile Asp Ala Ile  Thr Gly Glu Ala Arg  Tyr Ser Leu 
    1475                 1480                 1485             


Ser Glu  Asp Lys Leu Ile Arg  Gln Gln Ile Asp Tyr  Lys Thr Leu 
    1490                 1495                 1500             


Thr Leu  Asn Cys Val Asn Pro  Glu Asn Glu Asn Ala  Pro Glu Val 
    1505                 1510                 1515             


Pro Val  Lys Gly Leu Asp Cys  Asp Thr Val Thr Gln  Ala Lys Glu 
    1520                 1525                 1530             


Lys Leu  Leu Asp Ala Ala Tyr  Lys Gly Val Pro Tyr  Ser Gln Arg 
    1535                 1540                 1545             


Pro Lys  Ala Ala Asp Met Asp  Leu Glu Trp Arg Gln  Gly Arg Met 
    1550                 1555                 1560             


Ala Arg  Ile Ile Leu Gln Asp  Glu Asp Val Thr Thr  Lys Ile Asp 
    1565                 1570                 1575             


Asn Asp  Trp Lys Arg Leu Asn  Thr Leu Ala His Tyr  Gln Val Thr 
    1580                 1585                 1590             


Asp Gly  Ser Ser Val Ala Leu  Val Pro Lys Gln Thr  Ser Ala Tyr 
    1595                 1600                 1605             


Asn Ile  Ser Asn Ser Ser Thr  Phe Thr Lys Ser Leu  Ser Arg Tyr 
    1610                 1615                 1620             


Glu Ser  Met Leu Arg Thr Ala  Ser Ser Pro Asp Ser  Leu Arg Ser 
    1625                 1630                 1635             


Arg Thr  Pro Met Ile Thr Pro  Asp Leu Glu Ser Gly  Thr Lys Leu 
    1640                 1645                 1650             


Trp His  Leu Val Lys Asn His  Asp His Leu Asp Gln  Arg Glu Gly 
    1655                 1660                 1665             


Asp Arg  Gly Ser Lys Met Val  Ser Glu Ile Tyr Leu  Thr Arg Leu 
    1670                 1675                 1680             


Leu Ala  Thr Lys Gly Thr Leu  Gln Lys Phe Val Asp  Asp Leu Phe 
    1685                 1690                 1695             


Glu Thr  Ile Phe Ser Thr Ala  His Arg Gly Ser Ala  Leu Pro Leu 
    1700                 1705                 1710             


Ala Ile  Lys Tyr Met Phe Asp  Phe Leu Asp Glu Gln  Ala Asp Lys 
    1715                 1720                 1725             


His Gln  Ile His Asp Ala Asp  Val Arg His Thr Trp  Lys Ser Asn 
    1730                 1735                 1740             


Cys Leu  Pro Leu Arg Phe Trp  Val Asn Val Ile Lys  Asn Pro Gln 
    1745                 1750                 1755             


Phe Val  Phe Asp Ile His Lys  Asn Ser Ile Thr Asp  Ala Cys Leu 
    1760                 1765                 1770             


Ser Val  Val Ala Gln Thr Phe  Met Asp Ser Cys Ser  Thr Ser Glu 
    1775                 1780                 1785             


His Lys  Leu Gly Lys Asp Ser  Pro Ser Asn Lys Leu  Leu Tyr Ala 
    1790                 1795                 1800             


Lys Asp  Ile Pro Asn Tyr Lys  Ser Trp Val Glu Arg  Tyr Tyr Ala 
    1805                 1810                 1815             


Asp Ile  Ala Lys Met Pro Ala  Ile Ser Asp Gln Asp  Met Ser Ala 
    1820                 1825                 1830             


Tyr Leu  Ala Glu Gln Ser Arg  Leu His Leu Ser Gln  Phe Asn Ser 
    1835                 1840                 1845             


Met Ser  Ala Leu His Glu Ile  Tyr Ser Tyr Ile Thr  Lys Tyr Lys 
    1850                 1855                 1860             


Asp Glu  Ile Leu Ala Ala Leu  Glu Lys Asp Glu Gln  Ala Arg Arg 
    1865                 1870                 1875             


Gln Arg  Leu Arg Ser Lys Leu  Glu Gln Val Val Asp  Thr Met Ala 
    1880                 1885                 1890             


Leu Ser  Ser 
    1895     


<210>  2
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Ala Asp Pro Pro Arg Asp Ser Lys Gly Leu Ala Ala Ala Glu 
1               5                   10                  15      


Pro Thr Ala Asn Gly Gly Leu Ala Leu Ala Ser Ile Glu Asp Gln Gly 
            20                  25                  30          


Ala Ala Ala Gly Gly Tyr Cys Gly Ser Arg Asp Gln Val Arg Arg Cys 
        35                  40                  45              


Leu Arg Ala Asn Leu Leu Val Leu Leu Thr Val Val Ala Val Val Ala 
    50                  55                  60                  


Gly Val Ala Leu Gly Leu Gly Val Ser Gly Ala Gly Gly Ala Leu Ala 
65                  70                  75                  80  


Leu Gly Pro Glu Arg Leu Ser Ala Phe Val Phe Pro Gly Glu Leu Leu 
                85                  90                  95      


Leu Arg Leu Leu Arg Met Ile Ile Leu Pro Leu Val Val Cys Ser Leu 
            100                 105                 110         


Ile Gly Gly Ala Ala Ser Leu Asp Pro Gly Ala Leu Gly Arg Leu Gly 
        115                 120                 125             


Ala Trp Ala Leu Leu Phe Phe Leu Val Thr Thr Leu Leu Ala Ser Ala 
    130                 135                 140                 


Leu Gly Val Gly Leu Ala Leu Ala Leu Gln Pro Gly Ala Ala Ser Ala 
145                 150                 155                 160 


Ala Ile Asn Ala Ser Val Gly Ala Ala Gly Ser Ala Glu Asn Ala Pro 
                165                 170                 175     


Ser Lys Glu Val Leu Asp Ser Phe Leu Asp Leu Ala Arg Asn Ile Phe 
            180                 185                 190         


Pro Ser Asn Leu Val Ser Ala Ala Phe Arg Ser Tyr Ser Thr Thr Tyr 
        195                 200                 205             


Glu Glu Arg Asn Ile Thr Gly Thr Arg Val Lys Val Pro Val Gly Gln 
    210                 215                 220                 


Glu Val Glu Gly Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val 
225                 230                 235                 240 


Phe Gly Val Ala Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile 
                245                 250                 255     


Arg Phe Phe Asn Ser Phe Asn Glu Ala Thr Met Val Leu Val Ser Trp 
            260                 265                 270         


Ile Met Trp Tyr Ala Pro Val Gly Ile Met Phe Leu Val Ala Gly Lys 
        275                 280                 285             


Ile Val Glu Met Glu Asp Val Gly Leu Leu Phe Ala Arg Leu Gly Lys 
    290                 295                 300                 


Tyr Ile Leu Cys Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val 
305                 310                 315                 320 


Leu Pro Leu Ile Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe 
                325                 330                 335     


Leu Trp Gly Ile Val Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser 
            340                 345                 350         


Ser Ser Ala Thr Leu Pro Leu Met Met Lys Cys Val Glu Glu Asn Asn 
        355                 360                 365             


Gly Val Ala Lys His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr 
    370                 375                 380                 


Val Asn Met Asp Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe 
385                 390                 395                 400 


Ile Ala Gln Leu Ser Gln Gln Ser Leu Asp Phe Val Lys Ile Ile Thr 
                405                 410                 415     


Ile Leu Val Thr Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro 
            420                 425                 430         


Ala Gly Gly Val Leu Thr Leu Ala Ile Ile Leu Glu Ala Val Asn Leu 
        435                 440                 445             


Pro Val Asp His Ile Ser Leu Ile Leu Ala Val Asp Trp Leu Val Asp 
    450                 455                 460                 


Arg Ser Cys Thr Val Leu Asn Val Glu Gly Asp Ala Leu Gly Ala Gly 
465                 470                 475                 480 


Leu Leu Gln Asn Tyr Val Asp Arg Thr Glu Ser Arg Ser Thr Glu Pro 
                485                 490                 495     


Glu Leu Ile Gln Val Lys Ser Glu Leu Pro Leu Asp Pro Leu Pro Val 
            500                 505                 510         


Pro Thr Glu Glu Gly Asn Pro Leu Leu Lys His Tyr Arg Gly Pro Ala 
        515                 520                 525             


Gly Asp Ala Thr Val Ala Ser Glu Lys Glu Ser Val Met 
    530                 535                 540     


<210>  3
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala Leu Gly Val 
1               5                   10                  15      


Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile Val Met Val 
            20                  25                  30          


Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
        35                  40                  45              


Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr 
    50                  55                  60                  


Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys 
65                  70                  75                  80  


Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                85                  90                  95      


Phe Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser 
            100                 105                 110         


Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly 
        115                 120                 125             


Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala 
    130                 135                 140                 


Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr 
145                 150                 155                 160 


Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val 
                165                 170                 175     


Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn 
            180                 185                 190         


Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe 
        195                 200                 205             


Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly 
    210                 215                 220                 


Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
225                 230                 235                 240 


Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly 
                245                 250                 255     


Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu 
            260                 265                 270         


Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys 
        275                 280                 285             


Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro 
    290                 295                 300                 


Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe 
305                 310                 315                 320 


Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                325                 330                 335     


Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro 
            340                 345                 350         


Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His 
        355                 360                 365             


Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
    370                 375                 380                 


Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                405                 410                 415     


Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr 
            420                 425                 430         


Gln Leu Val Leu Met Pro Lys Val Met His Tyr Ala Gln Tyr Val Leu 
        435                 440                 445             


Leu Ala Leu Gly Cys Val Leu Leu Leu Val Pro Val Ile Cys Gln Ile 
    450                 455                 460                 


Arg Ser Gln Glu Lys Cys Tyr Leu Phe Trp Ser Ser Ser Lys Lys Gly 
465                 470                 475                 480 


Ser Lys Asp Lys Glu Ala Ile Gln Ala Tyr Ser Glu Ser Leu Met Thr 
                485                 490                 495     


Ser Ala Pro Lys Gly Ser Val Leu Gln Glu Ala Lys Leu 
            500                 505                 


<210>  4
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210>  5
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 
65                  70                  75                  80  


Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg 
                85                  90                  95      


Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 
            100                 105                 110         


Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 
        115                 120                 125             


Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe 
    130                 135                 140                 


Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser 
145                 150                 155                 160 


Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 
                165                 170                 175     


Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu 
            180                 185                 190         


Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr 
        195                 200                 205             


Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu 
    210                 215                 220                 


Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 
225                 230                 235                 240 


Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe 
                245                 250                 255     


His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly 
            260                 265                 270         


Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln 
        275                 280                 285             


Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 
    290                 295                 300                 


Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 
305                 310                 315                 320 


Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly 
                325                 330                 335     


Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 
            340                 345                 350         


Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 
        355                 360                 365             


Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 
    370                 375                 380                 


Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser 
385                 390                 395                 400 


Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 
                405                 410                 415     


Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro 
            420                 425                 430         


Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro 
        435                 440                 445             


Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 
    450                 455                 460                 


Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp 
465                 470                 475                 480 


Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 
                485                 490                 495     


Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr 
            500                 505                 510         


Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 
        515                 520                 525             


Gly Asn Lys Arg His Val Phe His Phe Gly Thr Val Ser Pro Gln Thr 
    530                 535                 540                 


Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 
545                 550                 555                 560 


Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 
                565                 570                 575     


Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro Pro Pro Gly Glu 
            580                 585                 590         


Pro Gly Leu Ser His Ser Gly Ser Glu Gln Pro Glu Gln Thr Gly Leu 
        595                 600                 605             


Leu Met Gly Gly Ala Ser Gly Gly Ala Arg Gly Gly Ser Gly Gly Phe 
    610                 615                 620                 


Gly Asp Glu Cys 
625             


<210>  6
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp 
1               5                   10                  15      


Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 
            20                  25                  30          


Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 
        35                  40                  45              


Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
    50                  55                  60                  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
65                  70                  75                  80  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His 
                85                  90                  95      


Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met 
            100                 105                 110         


Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 
        115                 120                 125             


Met Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp 
    130                 135                 140                 


Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 
145                 150                 155                 160 


Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val 
                165                 170                 175     


His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 
            180                 185                 190         


Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 
        195                 200                 205             


Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala 
    210                 215                 220                 


Tyr Tyr Gln Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val 
225                 230                 235                 240 


Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 
                245                 250             


<210>  7
<211>  895
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  8
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Ala Arg Glu Glu Ser Gly Ala Gly Ala Arg Pro Arg Arg Arg Ser 
1               5                   10                  15      


Ala Asp Ser Gly Ala Ala Gly Ala Gly Arg Gly Gly Gly Gly Glu Ala 
            20                  25                  30          


Ala Gly Lys Glu Glu Glu Gly Glu Ser Arg Ser Arg Arg Ala Ser Met 
        35                  40                  45              


Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu Ala 
    50                  55                  60                  


Leu Cys Arg Gly Arg Val Val Arg Val Pro Thr Ala Thr Leu Val Arg 
65                  70                  75                  80  


Val Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr Asp 
                85                  90                  95      


Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly Ser 
            100                 105                 110         


Ser Phe Val Glu Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala Gln 
        115                 120                 125             


Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg Thr 
    130                 135                 140                 


Ala Asn Asp Ala Val Glu Leu His Ile Lys Asn Val Gln Pro Ser Asp 
145                 150                 155                 160 


Gln Gly His Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val Gln 
                165                 170                 175     


Gly Asn Tyr Glu Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser Leu 
            180                 185                 190         


His Val Gly Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg Glu 
        195                 200                 205             


Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro Leu 
    210                 215                 220                 


His Thr His Leu Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala Arg 
225                 230                 235                 240 


Arg Ser Val Leu Ala Leu Thr His Glu Gly Arg Phe His Pro Gly Leu 
                245                 250                 255     


Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr Val 
            260                 265                 270         


Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala Asp 
        275                 280                 285             


Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln Gly 
    290                 295                 300                 


Asn Trp Gln Glu Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val Val 
305                 310                 315                 320 


Ile Gln Pro Ser Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser Val 
                325                 330                 335     


Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp Arg 
            340                 345                 350         


Ala Asp Asp Val Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met Pro 
        355                 360                 365             


Asp Ser Thr Leu Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg Asp 
    370                 375                 380                 


Ser Leu Val His Ser Ser Pro His Val Ala Leu Ser His Val Asp Ala 
385                 390                 395                 400 


Arg Ser Tyr His Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser Gly 
                405                 410                 415     


Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala Pro Gly His Asn Arg Ser 
            420                 425                 430         


Trp His Lys Val Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly Val 
        435                 440                 445             


Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys Val 
    450                 455                 460                 


Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val Asp 
465                 470                 475                 480 


Thr Lys Ser Gly Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr Tyr 
                485                 490                 495     


Arg Met Asn Arg Arg Ser Asp Asn Val Val Thr Ser Glu Leu Leu Ala 
            500                 505                 510         


Val Met Asp Gly Asp Trp Thr Leu Lys Tyr Gly Glu Arg Ser Lys Gln 
        515                 520                 525             


Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser Lys Glu His Thr Asp Thr 
    530                 535                 540                 


Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu Glu Asp Arg Gly Asn Tyr 
545                 550                 555                 560 


Tyr Cys Val Val Ser Ala Trp Thr Lys Gln Arg Asn Asn Ser Trp Val 
                565                 570                 575     


Lys Ser Lys Asp Val Phe Ser Lys Pro Val Asn Ile Phe Trp Ala Leu 
            580                 585                 590         


Glu Asp Ser Val Leu Val Val Lys Ala Arg Gln Pro Lys Pro Phe Phe 
        595                 600                 605             


Ala Ala Gly Asn Thr Phe Glu Met Thr Cys Lys Val Ser Ser Lys Asn 
    610                 615                 620                 


Ile Lys Ser Pro Arg Tyr Ser Val Leu Ile Met Ala Glu Lys Pro Val 
625                 630                 635                 640 


Gly Asp Leu Ser Ser Pro Asn Glu Thr Lys Tyr Ile Ile Ser Leu Asp 
                645                 650                 655     


Gln Asp Ser Val Val Lys Leu Glu Asn Trp Thr Asp Ala Ser Arg Val 
            660                 665                 670         


Asp Gly Val Val Leu Glu Lys Val Gln Glu Asp Glu Phe Arg Tyr Arg 
        675                 680                 685             


Met Tyr Gln Thr Gln Val Ser Asp Ala Gly Leu Tyr Arg Cys Met Val 
    690                 695                 700                 


Thr Ala Trp Ser Pro Val Arg Gly Ser Leu Trp Arg Glu Ala Ala Thr 
705                 710                 715                 720 


Ser Leu Ser Asn Pro Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro Ile 
                725                 730                 735     


Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser Val Ile Arg Gly Asp 
            740                 745                 750         


Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu Gly Ala Ala Leu Asp 
        755                 760                 765             


Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe Ala Val His Ser Phe 
    770                 775                 780                 


Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser Leu Asp Arg Lys Gly 
785                 790                 795                 800 


Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu Glu 
                805                 810                 815     


Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val His Gly Ser Glu Asp 
            820                 825                 830         


Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys Ser 
        835                 840                 845             


Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile His Ser Lys Pro Val 
    850                 855                 860                 


Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala Phe Lys Tyr Pro Leu 
865                 870                 875                 880 


Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly Leu Leu Ser Cys Leu 
                885                 890                 895     


Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys Lys Glu Val Gln Glu 
            900                 905                 910         


Thr Arg Arg Glu Arg Arg Arg Leu Met Ser Met Glu Met Asp 
        915                 920                 925     


<210>  9
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val 
            20                  25                  30          


Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser 
        35                  40                  45              


Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp 
    50                  55                  60                  


Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser 
65                  70                  75                  80  


Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val 
                85                  90                  95      


Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu 
            100                 105                 110         


Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His 
        115                 120                 125             


Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val 
    130                 135                 140                 


Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val 
                165                 170                 175     


His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr 
            180                 185                 190         


Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu 
        195                 200                 205             


Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser 
    210                 215                 220                 


Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala 
225                 230                 235                 240 


Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val 
                245                 250                 255     


Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala 
            260                 265                 270         


Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu 
        275                 280                 285             


Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln 
    290                 295                 300                 


Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu 
305                 310                 315                 320 


Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly 
                325                 330                 335     


Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala 
            340                 345                 350         


Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly 
        355                 360                 365             


Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val 
    370                 375                 380                 


Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp 
385                 390                 395                 400 


Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly 
                405                 410                 415     


Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val 
            420                 425                 430         


His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala 
        435                 440                 445             


Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile 
    450                 455                 460                 


Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp 
465                 470                 475                 480 


Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu 
                485                 490                 495     


Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro 
            500                 505                 510         


Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg 
        515                 520                 525             


Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys 
    530                 535                 540                 


Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala 
545                 550                 555                 560 


Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala 
                565                 570                 575     


Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu 
            580                 585                 590         


Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys 
        595                 600                 605             


Arg Leu Arg Lys Arg 
    610             


<210>  10
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  11
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Lys Ser Asn Gly Glu Glu Pro Lys Met Gly Gly Arg Met Glu 
1               5                   10                  15      


Arg Phe Gln Gln Gly Val Arg Lys Arg Thr Leu Leu Ala Lys Lys Lys 
            20                  25                  30          


Val Gln Asn Ile Thr Lys Glu Asp Val Lys Ser Tyr Leu Phe Arg Asn 
        35                  40                  45              


Ala Phe Val Leu Leu Thr Val Thr Ala Val Ile Val Gly Thr Ile Leu 
    50                  55                  60                  


Gly Phe Thr Leu Arg Pro Tyr Arg Met Ser Tyr Arg Glu Val Lys Tyr 
65                  70                  75                  80  


Phe Ser Phe Pro Gly Glu Leu Leu Met Arg Met Leu Gln Met Leu Val 
                85                  90                  95      


Leu Pro Leu Ile Ile Ser Ser Leu Val Thr Gly Met Ala Ala Leu Asp 
            100                 105                 110         


Ser Lys Ala Ser Gly Lys Met Gly Met Arg Ala Val Val Tyr Tyr Met 
        115                 120                 125             


Thr Thr Thr Ile Ile Ala Val Val Ile Gly Ile Ile Ile Val Ile Ile 
    130                 135                 140                 


Ile His Pro Gly Lys Gly Thr Lys Glu Asn Met His Arg Glu Gly Lys 
145                 150                 155                 160 


Ile Val Arg Val Thr Ala Ala Asp Ala Phe Leu Asp Leu Ile Arg Asn 
                165                 170                 175     


Met Phe Pro Pro Asn Leu Val Glu Ala Cys Phe Lys Gln Phe Lys Thr 
            180                 185                 190         


Asn Tyr Glu Lys Arg Ser Phe Lys Val Pro Ile Gln Ala Asn Glu Thr 
        195                 200                 205             


Leu Val Gly Ala Val Ile Asn Asn Val Ser Glu Ala Met Glu Thr Leu 
    210                 215                 220                 


Thr Arg Ile Thr Glu Glu Leu Val Pro Val Pro Gly Ser Val Asn Gly 
225                 230                 235                 240 


Val Asn Ala Leu Gly Leu Val Val Phe Ser Met Cys Phe Gly Phe Val 
                245                 250                 255     


Ile Gly Asn Met Lys Glu Gln Gly Gln Ala Leu Arg Glu Phe Phe Asp 
            260                 265                 270         


Ser Leu Asn Glu Ala Ile Met Arg Leu Val Ala Val Ile Met Trp Tyr 
        275                 280                 285             


Ala Pro Val Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Val Glu Met 
    290                 295                 300                 


Glu Asp Met Gly Val Ile Gly Gly Gln Leu Ala Met Tyr Thr Val Thr 
305                 310                 315                 320 


Val Ile Val Gly Leu Leu Ile His Ala Val Ile Val Leu Pro Leu Leu 
                325                 330                 335     


Tyr Phe Leu Val Thr Arg Lys Asn Pro Trp Val Phe Ile Gly Gly Leu 
            340                 345                 350         


Leu Gln Ala Leu Ile Thr Ala Leu Gly Thr Ser Ser Ser Ser Ala Thr 
        355                 360                 365             


Leu Pro Ile Thr Phe Lys Cys Leu Glu Glu Asn Asn Gly Val Asp Lys 
    370                 375                 380                 


Arg Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 
385                 390                 395                 400 


Gly Thr Ala Leu Tyr Glu Ala Leu Ala Ala Ile Phe Ile Ala Gln Val 
                405                 410                 415     


Asn Asn Phe Glu Leu Asn Phe Gly Gln Ile Ile Thr Ile Ser Ile Thr 
            420                 425                 430         


Ala Thr Ala Ala Ser Ile Gly Ala Ala Gly Ile Pro Gln Ala Gly Leu 
        435                 440                 445             


Val Thr Met Val Ile Val Leu Thr Ser Val Gly Leu Pro Thr Asp Asp 
    450                 455                 460                 


Ile Thr Leu Ile Ile Ala Val Asp Trp Phe Leu Asp Arg Leu Arg Thr 
465                 470                 475                 480 


Thr Thr Asn Val Leu Gly Asp Ser Leu Gly Ala Gly Ile Val Glu His 
                485                 490                 495     


Leu Ser Arg His Glu Leu Lys Asn Arg Asp Val Glu Met Gly Asn Ser 
            500                 505                 510         


Val Ile Glu Glu Asn Glu Met Lys Lys Pro Tyr Gln Leu Ile Ala Gln 
        515                 520                 525             


Asp Asn Glu Thr Glu Lys Pro Ile Asp Ser Glu Thr Lys Met 
    530                 535                 540         


<210>  12
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val 
1               5                   10                  15      


Asp Phe Arg Gln Tyr Val Arg Thr Leu Pro Thr Asn Thr Leu Met Gly 
            20                  25                  30          


Phe Gly Ala Phe Ala Ala Leu Thr Thr Phe Trp Tyr Ala Thr Arg Pro 
        35                  40                  45              


Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
    50                  55                  60                  


Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu 
65                  70                  75                  80  


Pro Leu Val Tyr Phe Tyr Asp Asp Val Thr Thr Leu Tyr Glu Gly Phe 
                85                  90                  95      


Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg 
            100                 105                 110         


Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu 
        115                 120                 125             


Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Thr 
    130                 135                 140                 


Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp 
145                 150                 155                 160 


Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro 
                165                 170                 175     


Leu Tyr Asp Thr Leu Gly Asn Glu Ala Ile Thr Tyr Ile Val Asn Lys 
            180                 185                 190         


Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu 
        195                 200                 205             


Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile 
    210                 215                 220                 


Val Val Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg 
225                 230                 235                 240 


Cys Gly Val Glu Val Thr Ser Met Lys Ala Met Glu Asp Leu Gly Arg 
                245                 250                 255     


Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val 
            260                 265                 270         


Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Val 
        275                 280                 285             


Thr His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Thr 
    290                 295                 300                 


Glu Asn Thr Val Asn Pro Cys Pro Asp Asp Thr Leu Ile Ser Phe Leu 
305                 310                 315                 320 


Pro Leu Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys 
                325                 330                 335     


His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met 
            340                 345                 350         


Asp Asp Leu Lys Val Leu Gln Pro Thr Val Phe Pro Val Val Pro Arg 
        355                 360                 365             


Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr Thr 
    370                 375                 380                 


Leu Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Glu 
385                 390                 395                 400 


Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile 
                405                 410                 415     


Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val 
            420                 425                 430         


Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg Ala 
        435                 440                 445             


Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr 
    450                 455                 460                 


Ala Gly Cys Cys Leu Thr Met Pro Gly Asp Trp Thr Ala Gly His Val 
465                 470                 475                 480 


Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu Val Asp Val Glu Glu 
                485                 490                 495     


Met Asn Tyr Met Ala Ala Glu Gly Glu Gly Glu Val Cys Val Lys Gly 
            500                 505                 510         


Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Thr Ala Glu 
        515                 520                 525             


Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp 
    530                 535                 540                 


Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe 
545                 550                 555                 560 


Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile 
                565                 570                 575     


Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser 
            580                 585                 590         


Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Thr Leu 
        595                 600                 605             


Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu 
    610                 615                 620                 


Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg 
625                 630                 635                 640 


Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile 
                645                 650                 655     


Thr Leu His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr Pro 
            660                 665                 670         


Thr Met Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln 
        675                 680                 685             


Ile Asp Asp Leu Tyr Ser Thr Ile Lys Val 
    690                 695             


<210>  13
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Leu Asp His Lys Asp Leu Glu Ala Glu Ile His Pro Leu Lys Asn 
1               5                   10                  15      


Glu Glu Arg Lys Ser Gln Glu Asn Leu Gly Asn Pro Ser Lys Asn Glu 
            20                  25                  30          


Asp Asn Val Lys Ser Ala Pro Pro Gln Ser Arg Leu Ser Arg Cys Arg 
        35                  40                  45              


Ala Ala Ala Phe Phe Leu Ser Leu Phe Leu Cys Leu Phe Val Val Phe 
    50                  55                  60                  


Val Val Ser Phe Val Ile Pro Cys Pro Asp Arg Pro Ala Ser Gln Arg 
65                  70                  75                  80  


Met Trp Arg Ile Asp Tyr Ser Ala Ala Val Ile Tyr Asp Phe Leu Ala 
                85                  90                  95      


Val Asp Asp Ile Asn Gly Asp Arg Ile Gln Asp Val Leu Phe Leu Tyr 
            100                 105                 110         


Lys Asn Thr Asn Ser Ser Asn Asn Phe Ser Arg Ser Cys Val Asp Glu 
        115                 120                 125             


Gly Phe Ser Ser Pro Cys Thr Phe Ala Ala Ala Val Ser Gly Ala Asn 
    130                 135                 140                 


Gly Ser Thr Leu Trp Glu Arg Pro Val Ala Gln Asp Val Ala Leu Val 
145                 150                 155                 160 


Glu Cys Ala Val Pro Gln Pro Arg Gly Ser Glu Ala Pro Ser Ala Cys 
                165                 170                 175     


Ile Leu Val Gly Arg Pro Ser Ser Phe Ile Ala Val Asn Leu Phe Thr 
            180                 185                 190         


Gly Glu Thr Leu Trp Asn His Ser Ser Ser Phe Ser Gly Asn Ala Ser 
        195                 200                 205             


Ile Leu Ser Pro Leu Leu Gln Val Pro Asp Val Asp Gly Asp Gly Ala 
    210                 215                 220                 


Pro Asp Leu Leu Val Leu Thr Gln Glu Arg Glu Glu Val Ser Gly His 
225                 230                 235                 240 


Leu Tyr Ser Gly Ser Thr Gly His Gln Ile Gly Leu Arg Gly Ser Leu 
                245                 250                 255     


Gly Val Asp Gly Glu Ser Gly Phe Leu Leu His Val Thr Arg Thr Gly 
            260                 265                 270         


Ala His Tyr Ile Leu Phe Pro Cys Ala Ser Ser Leu Cys Gly Cys Ser 
        275                 280                 285             


Val Lys Gly Leu Tyr Glu Lys Val Thr Gly Ser Gly Gly Pro Phe Lys 
    290                 295                 300                 


Ser Asp Pro His Trp Glu Ser Met Leu Asn Ala Thr Thr Arg Arg Met 
305                 310                 315                 320 


Leu Ser His Ser Ser Gly Ala Val Arg Tyr Leu Met His Val Pro Gly 
                325                 330                 335     


Asn Ala Gly Ala Asp Val Leu Leu Val Gly Ser Glu Ala Phe Val Leu 
            340                 345                 350         


Leu Asp Gly Gln Glu Leu Thr Pro Arg Trp Thr Pro Lys Ala Ala His 
        355                 360                 365             


Val Leu Arg Lys Pro Ile Phe Gly Arg Tyr Lys Pro Asp Thr Leu Ala 
    370                 375                 380                 


Val Ala Val Glu Asn Gly Thr Gly Thr Asp Arg Gln Ile Leu Phe Leu 
385                 390                 395                 400 


Asp Leu Gly Thr Gly Ala Val Leu Cys Ser Leu Ala Leu Pro Ser Leu 
                405                 410                 415     


Pro Gly Gly Pro Leu Ser Ala Ser Leu Pro Thr Ala Asp His Arg Ser 
            420                 425                 430         


Ala Phe Phe Phe Trp Gly Leu His Glu Leu Gly Ser Thr Ser Glu Thr 
        435                 440                 445             


Glu Thr Gly Glu Ala Arg His Ser Leu Tyr Met Phe His Pro Thr Leu 
    450                 455                 460                 


Pro Arg Val Leu Leu Glu Leu Ala Asn Val Ser Thr His Ile Val Ala 
465                 470                 475                 480 


Phe Asp Ala Val Leu Phe Glu Pro Ser Arg His Ala Ala Tyr Ile Leu 
                485                 490                 495     


Leu Thr Gly Pro Ala Asp Ser Glu Ala Pro Gly Leu Val Ser Val Ile 
            500                 505                 510         


Lys His Lys Val Arg Asp Leu Val Pro Ser Ser Arg Val Val Arg Leu 
        515                 520                 525             


Gly Glu Gly Gly Pro Asp Ser Asp Gln Ala Ile Arg Asp Arg Phe Ser 
    530                 535                 540                 


Arg Leu Arg Tyr Gln Ser Glu Ala 
545                 550         


<210>  14
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Leu Pro Glu Pro Gly Pro Leu Arg Leu Leu Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gln Leu Gln His Leu Ala Ala Ala 
            20                  25                  30          


Ala Ala Asp Pro Leu Leu Gly Gly Gln Gly Pro Ala Lys Asp Cys Glu 
        35                  40                  45              


Lys Asp Gln Phe Gln Cys Arg Asn Glu Arg Cys Ile Pro Ser Val Trp 
    50                  55                  60                  


Arg Cys Asp Glu Asp Asp Asp Cys Leu Asp His Ser Asp Glu Asp Asp 
65                  70                  75                  80  


Cys Pro Lys Lys Thr Cys Ala Asp Ser Asp Phe Thr Cys Asp Asn Gly 
                85                  90                  95      


His Cys Ile His Glu Arg Trp Lys Cys Asp Gly Glu Glu Glu Cys Pro 
            100                 105                 110         


Asp Gly Ser Asp Glu Ser Glu Ala Thr Cys Thr Lys Gln Val Cys Pro 
        115                 120                 125             


Ala Glu Lys Leu Ser Cys Gly Pro Thr Ser His Lys Cys Val Pro Ala 
    130                 135                 140                 


Ser Trp Arg Cys Asp Gly Glu Lys Asp Cys Glu Gly Gly Ala Asp Glu 
145                 150                 155                 160 


Ala Gly Cys Ala Thr Leu Cys Ala Pro His Glu Phe Gln Cys Gly Asn 
                165                 170                 175     


Arg Ser Cys Leu Ala Ala Val Phe Val Cys Asp Gly Asp Asp Asp Cys 
            180                 185                 190         


Gly Asp Gly Ser Asp Glu Arg Gly Cys Ala Asp Pro Ala Cys Gly Pro 
        195                 200                 205             


Arg Glu Phe Arg Cys Gly Gly Asp Gly Gly Gly Ala Cys Ile Pro Glu 
    210                 215                 220                 


Arg Trp Val Cys Asp Arg Gln Phe Asp Cys Glu Asp Arg Ser Asp Glu 
225                 230                 235                 240 


Ala Ala Glu Leu Cys Gly Arg Pro Gly Pro Gly Ala Thr Ser Ala Pro 
                245                 250                 255     


Ala Ala Cys Ala Thr Ala Ser Gln Phe Ala Cys Arg Ser Gly Glu Cys 
            260                 265                 270         


Val His Leu Gly Trp Arg Cys Asp Gly Asp Arg Asp Cys Lys Asp Lys 
        275                 280                 285             


Ser Asp Glu Ala Asp Cys Pro Leu Gly Thr Cys Arg Gly Asp Glu Phe 
    290                 295                 300                 


Gln Cys Gly Asp Gly Thr Cys Val Leu Ala Ile Lys His Cys Asn Gln 
305                 310                 315                 320 


Glu Gln Asp Cys Pro Asp Gly Ser Asp Glu Ala Gly Cys Leu Gln Gly 
                325                 330                 335     


Leu Asn Glu Cys Leu His Asn Asn Gly Gly Cys Ser His Ile Cys Thr 
            340                 345                 350         


Asp Leu Lys Ile Gly Phe Glu Cys Thr Cys Pro Ala Gly Phe Gln Leu 
        355                 360                 365             


Leu Asp Gln Lys Thr Cys Gly Asp Ile Asp Glu Cys Lys Asp Pro Asp 
    370                 375                 380                 


Ala Cys Ser Gln Ile Cys Val Asn Tyr Lys Gly Tyr Phe Lys Cys Glu 
385                 390                 395                 400 


Cys Tyr Pro Gly Tyr Glu Met Asp Leu Leu Thr Lys Asn Cys Lys Ala 
                405                 410                 415     


Ala Ala Gly Lys Ser Pro Ser Leu Ile Phe Thr Asn Arg His Glu Val 
            420                 425                 430         


Arg Arg Ile Asp Leu Val Lys Arg Asn Tyr Ser Arg Leu Ile Pro Met 
        435                 440                 445             


Leu Lys Asn Val Val Ala Leu Asp Val Glu Val Ala Thr Asn Arg Ile 
    450                 455                 460                 


Tyr Trp Cys Asp Leu Ser Tyr Arg Lys Ile Tyr Ser Ala Tyr Met Asp 
465                 470                 475                 480 


Lys Ala Ser Asp Pro Lys Glu Gln Glu Val Leu Ile Asp Glu Gln Leu 
                485                 490                 495     


His Ser Pro Glu Gly Leu Ala Val Asp Trp Val His Lys His Ile Tyr 
            500                 505                 510         


Trp Thr Asp Ser Gly Asn Lys Thr Ile Ser Val Ala Thr Val Asp Gly 
        515                 520                 525             


Gly Arg Arg Arg Thr Leu Phe Ser Arg Asn Leu Ser Glu Pro Arg Ala 
    530                 535                 540                 


Ile Ala Val Asp Pro Leu Arg Gly Phe Met Tyr Trp Ser Asp Trp Gly 
545                 550                 555                 560 


Asp Gln Ala Lys Ile Glu Lys Ser Gly Leu Asn Gly Val Asp Arg Gln 
                565                 570                 575     


Thr Leu Val Ser Asp Asn Ile Glu Trp Pro Asn Gly Ile Thr Leu Asp 
            580                 585                 590         


Leu Leu Ser Gln Arg Leu Tyr Trp Val Asp Ser Lys Leu His Gln Leu 
        595                 600                 605             


Ser Ser Ile Asp Phe Ser Gly Gly Asn Arg Lys Thr Leu Ile Ser Ser 
    610                 615                 620                 


Thr Asp Phe Leu Ser His Pro Phe Gly Ile Ala Val Phe Glu Asp Lys 
625                 630                 635                 640 


Val Phe Trp Thr Asp Leu Glu Asn Glu Ala Ile Phe Ser Ala Asn Arg 
                645                 650                 655     


Leu Asn Gly Leu Glu Ile Ser Ile Leu Ala Glu Asn Leu Asn Asn Pro 
            660                 665                 670         


His Asp Ile Val Ile Phe His Glu Leu Lys Gln Pro Arg Ala Pro Asp 
        675                 680                 685             


Ala Cys Glu Leu Ser Val Gln Pro Asn Gly Gly Cys Glu Tyr Leu Cys 
    690                 695                 700                 


Leu Pro Ala Pro Gln Ile Ser Ser His Ser Pro Lys Tyr Thr Cys Ala 
705                 710                 715                 720 


Cys Pro Asp Thr Met Trp Leu Gly Pro Asp Met Lys Arg Cys Tyr Arg 
                725                 730                 735     


Ala Pro Gln Ser Thr Ser Thr Thr Thr Leu Ala Ser Thr Met Thr Arg 
            740                 745                 750         


Thr Val Pro Ala Thr Thr Arg Ala Pro Gly Thr Thr Val His Arg Ser 
        755                 760                 765             


Thr Tyr Gln Asn His Ser Thr Glu Thr Pro Ser Leu Thr Ala Ala Val 
    770                 775                 780                 


Pro Ser Ser Val Ser Val Pro Arg Ala Pro Ser Ile Ser Pro Ser Thr 
785                 790                 795                 800 


Leu Ser Pro Ala Thr Ser Asn His Ser Gln His Tyr Ala Asn Glu Asp 
                805                 810                 815     


Ser Lys Met Gly Ser Thr Val Thr Ala Ala Val Ile Gly Ile Ile Val 
            820                 825                 830         


Pro Ile Val Val Ile Ala Leu Leu Cys Met Ser Gly Tyr Leu Ile Trp 
        835                 840                 845             


Arg Asn Trp Lys Arg Lys Asn Thr Lys Ser Met Asn Phe Asp Asn Pro 
    850                 855                 860                 


Val Tyr Arg Lys Thr Thr Glu Glu Glu Asp Glu Asp Glu Leu His Ile 
865                 870                 875                 880 


Gly Arg Thr Ala Gln Ile Gly His Val Tyr Pro Ala Ala Ile Ser Ser 
                885                 890                 895     


Phe Asp Arg Pro Leu Trp Ala Glu Pro Cys Leu Gly Glu Thr Arg Glu 
            900                 905                 910         


Pro Glu Asp Pro Ala Pro Ala Leu Lys Glu Leu Phe Val Leu Pro Gly 
        915                 920                 925             


Glu Pro Arg Ser Gln Leu His Gln Leu Pro Lys Asn Pro Leu Ser Glu 
    930                 935                 940                 


Leu Pro Val Val Lys Ser Lys Arg Val Ala Leu Ser Leu Glu Asp Asp 
945                 950                 955                 960 


Gly Leu Pro 
            


<210>  15
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Gly Ser Met Ala Thr Ala Glu Ala Ser Gly Ser Asp Gly Lys 
1               5                   10                  15      


Gly Gln Glu Val Glu Thr Ser Val Thr Tyr Tyr Arg Leu Glu Glu Val 
            20                  25                  30          


Ala Lys Arg Asn Ser Leu Lys Glu Leu Trp Leu Val Ile His Gly Arg 
        35                  40                  45              


Val Tyr Asp Val Thr Arg Phe Leu Asn Glu His Pro Gly Gly Glu Glu 
    50                  55                  60                  


Val Leu Leu Glu Gln Ala Gly Val Asp Ala Ser Glu Ser Phe Glu Asp 
65                  70                  75                  80  


Val Gly His Ser Ser Asp Ala Arg Glu Met Leu Lys Gln Tyr Tyr Ile 
                85                  90                  95      


Gly Asp Ile His Pro Ser Asp Leu Lys Pro Glu Ser Gly Ser Lys Asp 
            100                 105                 110         


Pro Ser Lys Asn Asp Thr Cys Lys Ser Cys Trp Ala Tyr Trp Ile Leu 
        115                 120                 125             


Pro Ile Ile Gly Ala Val Leu Leu Gly Phe Leu Tyr Arg Tyr Tyr Thr 
    130                 135                 140                 


Ser Glu Ser Lys Ser Ser 
145                 150 


<210>  16
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Asn Gly Thr Gly Gly 
1               5                   10                  15      


Ser Ser Gly Met Glu Val Asp Ala Ala Val Val Pro Ser Val Met Ala 
            20                  25                  30          


Cys Gly Val Thr Gly Ser Val Ser Val Ala Leu His Pro Leu Val Ile 
        35                  40                  45              


Leu Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu Gly Arg 
    50                  55                  60                  


Pro Val Gln Val Ile Gly Ala Leu Ile Gly Lys Gln Glu Gly Arg Asn 
65                  70                  75                  80  


Ile Glu Val Met Asn Ser Phe Glu Leu Leu Ser His Thr Val Glu Glu 
                85                  90                  95      


Lys Ile Ile Ile Asp Lys Glu Tyr Tyr Tyr Thr Lys Glu Glu Gln Phe 
            100                 105                 110         


Lys Gln Val Phe Lys Glu Leu Glu Phe Leu Gly Trp Tyr Thr Thr Gly 
        115                 120                 125             


Gly Pro Pro Asp Pro Ser Asp Ile His Val His Lys Gln Val Cys Glu 
    130                 135                 140                 


Ile Ile Glu Ser Pro Leu Phe Leu Lys Leu Asn Pro Met Thr Lys His 
145                 150                 155                 160 


Thr Asp Leu Pro Val Ser Val Phe Glu Ser Val Ile Asp Ile Ile Asn 
                165                 170                 175     


Gly Glu Ala Thr Met Leu Phe Ala Glu Leu Thr Tyr Thr Leu Ala Thr 
            180                 185                 190         


Glu Glu Ala Glu Arg Ile Gly Val Asp His Val Ala Arg Met Thr Ala 
        195                 200                 205             


Thr Gly Ser Gly Glu Asn Ser Thr Val Ala Glu His Leu Ile Ala Gln 
    210                 215                 220                 


His Ser Ala Ile Lys Met Leu His Ser Arg Val Lys Leu Ile Leu Glu 
225                 230                 235                 240 


Tyr Val Lys Ala Ser Glu Ala Gly Glu Val Pro Phe Asn His Glu Ile 
                245                 250                 255     


Leu Arg Glu Ala Tyr Ala Leu Cys His Cys Leu Pro Val Leu Ser Thr 
            260                 265                 270         


Asp Lys Phe Lys Thr Asp Phe Tyr Asp Gln Cys Asn Asp Val Gly Leu 
        275                 280                 285             


Met Ala Tyr Leu Gly Thr Ile Thr Lys Thr Cys Asn Thr Met Asn Gln 
    290                 295                 300                 


Phe Val Asn Lys Phe Asn Val Leu Tyr Asp Arg Gln Gly Ile Gly Arg 
305                 310                 315                 320 


Arg Met Arg Gly Leu Phe Phe 
                325         


<210>  17
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Gln Lys Gly Val Leu Gly Pro Gly Gln Leu Gly Ala Val Ala 
1               5                   10                  15      


Ile Leu Leu Tyr Leu Gly Leu Leu Arg Ser Gly Thr Gly Lys Glu Gly 
            20                  25                  30          


Ala Ala Ala Pro Cys Gly Val Ala Pro Gln Ala Arg Ile Thr Gly Gly 
        35                  40                  45              


Ser Ser Ala Val Ala Gly Gln Trp Pro Trp Gln Val Ser Ile Thr Tyr 
    50                  55                  60                  


Glu Gly Val His Val Cys Gly Gly Ser Leu Val Ser Glu Gln Trp Val 
65                  70                  75                  80  


Leu Ser Ala Ala His Cys Phe Pro Ser Glu His His Lys Glu Ala Tyr 
                85                  90                  95      


Glu Val Lys Leu Gly Ala His Gln Leu Asp Ser Tyr Ser Glu Asp Ala 
            100                 105                 110         


Lys Val Ser Thr Leu Lys Asp Ile Ile Pro His Pro Ser Tyr Leu Gln 
        115                 120                 125             


Glu Gly Ser Gln Gly Asp Ile Ala Leu Leu Gln Leu Ser Arg Pro Ile 
    130                 135                 140                 


Thr Phe Ser Arg Tyr Ile Arg Pro Ile Cys Leu Pro Ala Ala Asn Ala 
145                 150                 155                 160 


Ser Phe Pro Asn Gly Leu His Cys Thr Val Thr Gly Trp Gly His Val 
                165                 170                 175     


Ala Pro Ser Val Ser Leu Leu Thr Pro Lys Pro Leu Gln Gln Leu Glu 
            180                 185                 190         


Val Pro Leu Ile Ser Arg Glu Thr Cys Asn Cys Leu Tyr Asn Ile Asp 
        195                 200                 205             


Ala Lys Pro Glu Glu Pro His Phe Val Gln Glu Asp Met Val Cys Ala 
    210                 215                 220                 


Gly Tyr Val Glu Gly Gly Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly 
225                 230                 235                 240 


Pro Leu Ser Cys Pro Val Glu Gly Leu Trp Tyr Leu Thr Gly Ile Val 
                245                 250                 255     


Ser Trp Gly Asp Ala Cys Gly Ala Arg Asn Arg Pro Gly Val Tyr Thr 
            260                 265                 270         


Leu Ala Ser Ser Tyr Ala Ser Trp Ile Gln Ser Lys Val Thr Glu Leu 
        275                 280                 285             


Gln Pro Arg Val Val Pro Gln Thr Gln Glu Ser Gln Pro Asp Ser Asn 
    290                 295                 300                 


Leu Cys Gly Ser His Leu Ala Phe Ser Ser Ala Pro Ala Gln Gly Leu 
305                 310                 315                 320 


Leu Arg Pro Ile Leu Phe Leu Pro Leu Gly Leu Ala Leu Gly Leu Leu 
                325                 330                 335     


Ser Pro Trp Leu Ser Glu His 
            340             


<210>  18
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu 
            20                  25                  30          


Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val 
        35                  40                  45              


Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly 
    50                  55                  60                  


Asp Leu Asp Asp Leu Glu Asp Ser Met Ile Gly Pro Glu Val Val His 
65                  70                  75                  80  


Pro Leu Val Pro Leu Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly 
                85                  90                  95      


Ser Gln Val Pro Thr Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile 
            100                 105                 110         


Pro Lys Arg Ile Ser Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys 
        115                 120                 125             


Val Ser Met Ser Ser Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr 
    130                 135                 140                 


Glu Val Leu Ala Ala Leu Ile Val Gly Gly Ile Val Gly Ile Leu Phe 
145                 150                 155                 160 


Ala Val Phe Leu Ile Leu Leu Leu Met Tyr Arg Met Lys Lys Lys Asp 
                165                 170                 175     


Glu Gly Ser Tyr Asp Leu Gly Lys Lys Pro Ile Tyr Lys Lys Ala Pro 
            180                 185                 190         


Thr Asn Glu Phe Tyr Ala 
        195             


<210>  19
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Glu Pro Ser Ser Lys Lys Leu Thr Gly Arg Leu Met Leu Ala Val 
1               5                   10                  15      


Gly Gly Ala Val Leu Gly Ser Leu Gln Phe Gly Tyr Asn Thr Gly Val 
            20                  25                  30          


Ile Asn Ala Pro Gln Lys Val Ile Glu Glu Phe Tyr Asn Gln Thr Trp 
        35                  40                  45              


Val His Arg Tyr Gly Glu Ser Ile Leu Pro Thr Thr Leu Thr Thr Leu 
    50                  55                  60                  


Trp Ser Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser 
65                  70                  75                  80  


Phe Ser Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met 
                85                  90                  95      


Leu Met Met Asn Leu Leu Ala Phe Val Ser Ala Val Leu Met Gly Phe 
            100                 105                 110         


Ser Lys Leu Gly Lys Ser Phe Glu Met Leu Ile Leu Gly Arg Phe Ile 
        115                 120                 125             


Ile Gly Val Tyr Cys Gly Leu Thr Thr Gly Phe Val Pro Met Tyr Val 
    130                 135                 140                 


Gly Glu Val Ser Pro Thr Ala Leu Arg Gly Ala Leu Gly Thr Leu His 
145                 150                 155                 160 


Gln Leu Gly Ile Val Val Gly Ile Leu Ile Ala Gln Val Phe Gly Leu 
                165                 170                 175     


Asp Ser Ile Met Gly Asn Lys Asp Leu Trp Pro Leu Leu Leu Ser Ile 
            180                 185                 190         


Ile Phe Ile Pro Ala Leu Leu Gln Cys Ile Val Leu Pro Phe Cys Pro 
        195                 200                 205             


Glu Ser Pro Arg Phe Leu Leu Ile Asn Arg Asn Glu Glu Asn Arg Ala 
    210                 215                 220                 


Lys Ser Val Leu Lys Lys Leu Arg Gly Thr Ala Asp Val Thr His Asp 
225                 230                 235                 240 


Leu Gln Glu Met Lys Glu Glu Ser Arg Gln Met Met Arg Glu Lys Lys 
                245                 250                 255     


Val Thr Ile Leu Glu Leu Phe Arg Ser Pro Ala Tyr Arg Gln Pro Ile 
            260                 265                 270         


Leu Ile Ala Val Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn 
        275                 280                 285             


Ala Val Phe Tyr Tyr Ser Thr Ser Ile Phe Glu Lys Ala Gly Val Gln 
    290                 295                 300                 


Gln Pro Val Tyr Ala Thr Ile Gly Ser Gly Ile Val Asn Thr Ala Phe 
305                 310                 315                 320 


Thr Val Val Ser Leu Phe Val Val Glu Arg Ala Gly Arg Arg Thr Leu 
                325                 330                 335     


His Leu Ile Gly Leu Ala Gly Met Ala Gly Cys Ala Ile Leu Met Thr 
            340                 345                 350         


Ile Ala Leu Ala Leu Leu Glu Gln Leu Pro Trp Met Ser Tyr Leu Ser 
        355                 360                 365             


Ile Val Ala Ile Phe Gly Phe Val Ala Phe Phe Glu Val Gly Pro Gly 
    370                 375                 380                 


Pro Ile Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg 
385                 390                 395                 400 


Pro Ala Ala Ile Ala Val Ala Gly Phe Ser Asn Trp Thr Ser Asn Phe 
                405                 410                 415     


Ile Val Gly Met Cys Phe Gln Tyr Val Glu Gln Leu Cys Gly Pro Tyr 
            420                 425                 430         


Val Phe Ile Ile Phe Thr Val Leu Leu Val Leu Phe Phe Ile Phe Thr 
        435                 440                 445             


Tyr Phe Lys Val Pro Glu Thr Lys Gly Arg Thr Phe Asp Glu Ile Ala 
    450                 455                 460                 


Ser Gly Phe Arg Gln Gly Gly Ala Ser Gln Ser Asp Lys Thr Pro Glu 
465                 470                 475                 480 


Glu Leu Phe His Pro Leu Gly Ala Asp Ser Gln Val 
                485                 490         


<210>  20
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly 
1               5                   10                  15      


Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu 
            20                  25                  30          


Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala 
        35                  40                  45              


Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg 
    50                  55                  60                  


Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly 
65                  70                  75                  80  


Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met 
                85                  90                  95      


Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys 
            100                 105                 110         


Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln 
        115                 120                 125             


Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu 
    130                 135                 140                 


Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser 
145                 150                 155                 160 


Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser 
                165                 170                 175     


Ala Leu Leu Gln 
            180 


<210>  21
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Arg Lys Val Val Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Leu 
1               5                   10                  15      


Ala Leu Cys Lys Arg Leu Leu Ala Glu Asp Asp Glu Leu His Leu Cys 
            20                  25                  30          


Leu Ala Cys Arg Asn Met Ser Lys Ala Glu Ala Val Cys Ala Ala Leu 
        35                  40                  45              


Leu Ala Ser His Pro Thr Ala Glu Val Thr Ile Val Gln Val Asp Val 
    50                  55                  60                  


Ser Asn Leu Gln Ser Val Phe Arg Ala Ser Lys Glu Leu Lys Gln Arg 
65                  70                  75                  80  


Phe Gln Arg Leu Asp Cys Ile Tyr Leu Asn Ala Gly Ile Met Pro Asn 
                85                  90                  95      


Pro Gln Leu Asn Ile Lys Ala Leu Phe Phe Gly Leu Phe Ser Arg Lys 
            100                 105                 110         


Val Ile His Met Phe Ser Thr Ala Glu Gly Leu Leu Thr Gln Gly Asp 
        115                 120                 125             


Lys Ile Thr Ala Asp Gly Leu Gln Glu Val Phe Glu Thr Asn Val Phe 
    130                 135                 140                 


Gly His Phe Ile Leu Ile Arg Glu Leu Glu Pro Leu Leu Cys His Ser 
145                 150                 155                 160 


Asp Asn Pro Ser Gln Leu Ile Trp Thr Ser Ser Arg Ser Ala Arg Lys 
                165                 170                 175     


Ser Asn Phe Ser Leu Glu Asp Phe Gln His Ser Lys Gly Lys Glu Pro 
            180                 185                 190         


Tyr Ser Ser Ser Lys Tyr Ala Thr Asp Leu Leu Ser Val Ala Leu Asn 
        195                 200                 205             


Arg Asn Phe Asn Gln Gln Gly Leu Tyr Ser Asn Val Ala Cys Pro Gly 
    210                 215                 220                 


Thr Ala Leu Thr Asn Leu Thr Tyr Gly Ile Leu Pro Pro Phe Ile Trp 
225                 230                 235                 240 


Thr Leu Leu Met Pro Ala Ile Leu Leu Leu Arg Phe Phe Ala Asn Ala 
                245                 250                 255     


Phe Thr Leu Thr Pro Tyr Asn Gly Thr Glu Ala Leu Val Trp Leu Phe 
            260                 265                 270         


His Gln Lys Pro Glu Ser Leu Asn Pro Leu Ile Lys Tyr Leu Ser Ala 
        275                 280                 285             


Thr Thr Gly Phe Gly Arg Asn Tyr Ile Met Thr Gln Lys Met Asp Leu 
    290                 295                 300                 


Asp Glu Asp Thr Ala Glu Lys Phe Tyr Gln Lys Leu Leu Glu Leu Glu 
305                 310                 315                 320 


Lys His Ile Arg Val Thr Ile Gln Lys Thr Asp Asn Gln Ala Arg Leu 
                325                 330                 335     


Ser Gly Ser Cys Leu 
            340     


<210>  22
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Leu Gln Leu Gly Arg Leu Ser Ser Gly Pro Cys Trp Leu Val 
1               5                   10                  15      


Ala Arg Gly Gly Cys Gly Gly Pro Arg Ala Trp Ser Gln Cys Gly Gly 
            20                  25                  30          


Gly Gly Leu Arg Ala Trp Ser Gln Arg Ser Ala Ala Gly Arg Val Cys 
        35                  40                  45              


Arg Pro Pro Gly Pro Ala Gly Thr Glu Gln Ser Arg Gly Leu Gly His 
    50                  55                  60                  


Gly Ser Thr Ser Arg Gly Gly Pro Trp Val Gly Thr Gly Leu Ala Ala 
65                  70                  75                  80  


Ala Leu Ala Gly Leu Val Gly Leu Ala Thr Ala Ala Phe Gly His Val 
                85                  90                  95      


Gln Arg Ala Glu Met Leu Pro Lys Thr Ser Gly Thr Arg Ala Thr Ser 
            100                 105                 110         


Leu Gly Arg Pro Glu Glu Glu Glu Asp Glu Leu Ala His Arg Cys Ser 
        115                 120                 125             


Ser Phe Met Ala Pro Pro Val Thr Asp Leu Gly Glu Leu Arg Arg Arg 
    130                 135                 140                 


Pro Gly Asp Met Lys Thr Lys Met Glu Leu Leu Ile Leu Glu Thr Gln 
145                 150                 155                 160 


Ala Gln Val Cys Gln Ala Leu Ala Gln Val Asp Gly Gly Ala Asn Phe 
                165                 170                 175     


Ser Val Asp Arg Trp Glu Arg Lys Glu Gly Gly Gly Gly Ile Ser Cys 
            180                 185                 190         


Val Leu Gln Asp Gly Cys Val Phe Glu Lys Ala Gly Val Ser Ile Ser 
        195                 200                 205             


Val Val His Gly Asn Leu Ser Glu Glu Ala Ala Lys Gln Met Arg Ser 
    210                 215                 220                 


Arg Gly Lys Val Leu Lys Thr Lys Asp Gly Lys Leu Pro Phe Cys Ala 
225                 230                 235                 240 


Met Gly Val Ser Ser Val Ile His Pro Lys Asn Pro His Ala Pro Thr 
                245                 250                 255     


Ile His Phe Asn Tyr Arg Tyr Phe Glu Val Glu Glu Ala Asp Gly Asn 
            260                 265                 270         


Lys Gln Trp Trp Phe Gly Gly Gly Cys Asp Leu Thr Pro Thr Tyr Leu 
        275                 280                 285             


Asn Gln Glu Asp Ala Val His Phe His Arg Thr Leu Lys Glu Ala Cys 
    290                 295                 300                 


Asp Gln His Gly Pro Asp Leu Tyr Pro Lys Phe Lys Lys Trp Cys Asp 
305                 310                 315                 320 


Asp Tyr Phe Phe Ile Ala His Arg Gly Glu Arg Arg Gly Ile Gly Gly 
                325                 330                 335     


Ile Phe Phe Asp Asp Leu Asp Ser Pro Ser Lys Glu Glu Val Phe Arg 
            340                 345                 350         


Phe Val Gln Ser Cys Ala Arg Ala Val Val Pro Ser Tyr Ile Pro Leu 
        355                 360                 365             


Val Lys Lys His Cys Asp Asp Ser Phe Thr Pro Gln Glu Lys Leu Trp 
    370                 375                 380                 


Gln Gln Leu Arg Arg Gly Arg Tyr Val Glu Phe Asn Leu Leu Tyr Asp 
385                 390                 395                 400 


Arg Gly Thr Lys Phe Gly Leu Phe Thr Pro Gly Ser Arg Ile Glu Ser 
                405                 410                 415     


Ile Leu Met Ser Leu Pro Leu Thr Ala Arg Trp Glu Tyr Met His Ser 
            420                 425                 430         


Pro Ser Glu Asn Ser Lys Glu Ala Glu Ile Leu Glu Val Leu Arg His 
        435                 440                 445             


Pro Arg Asp Trp Val Arg 
    450                 


<210>  23
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Arg Cys Ala Leu Ala Leu Ser Ala Leu Leu Leu Leu Leu Ser Thr 
1               5                   10                  15      


Pro Pro Leu Leu Pro Ser Ser Pro Ser Pro Ser Pro Ser Pro Ser Gln 
            20                  25                  30          


Asn Glu Thr Ala Thr Gln Thr Thr Thr Asp Ser Ser Asn Lys Thr Ala 
        35                  40                  45              


Pro Thr Pro Ala Ser Ser Val Thr Ile Met Ala Thr Asp Thr Ala Gln 
    50                  55                  60                  


Gln Ser Thr Val Pro Thr Ser Lys Ala Asn Glu Ile Leu Ala Ser Val 
65                  70                  75                  80  


Lys Ala Thr Thr Leu Gly Val Ser Ser Asp Ser Pro Gly Thr Thr Thr 
                85                  90                  95      


Leu Ala Gln Gln Val Ser Gly Pro Val Asn Thr Thr Val Ala Arg Gly 
            100                 105                 110         


Gly Gly Ser Gly Asn Pro Thr Thr Thr Ile Glu Ser Pro Lys Ser Thr 
        115                 120                 125             


Lys Ser Ala Asp Thr Thr Thr Val Ala Thr Ser Thr Ala Thr Ala Lys 
    130                 135                 140                 


Pro Asn Thr Thr Ser Ser Gln Asn Gly Ala Glu Asp Thr Thr Asn Ser 
145                 150                 155                 160 


Gly Gly Lys Ser Ser His Ser Val Thr Thr Asp Leu Thr Ser Thr Lys 
                165                 170                 175     


Ala Glu His Leu Thr Thr Pro His Pro Thr Ser Pro Leu Ser Pro Arg 
            180                 185                 190         


Gln Pro Thr Ser Thr His Pro Val Ala Thr Pro Thr Ser Ser Gly His 
        195                 200                 205             


Asp His Leu Met Lys Ile Ser Ser Ser Ser Ser Thr Val Ala Ile Pro 
    210                 215                 220                 


Gly Tyr Thr Phe Thr Ser Pro Gly Met Thr Thr Thr Leu Pro Ser Ser 
225                 230                 235                 240 


Val Ile Ser Gln Arg Thr Gln Gln Thr Ser Ser Gln Met Pro Ala Ser 
                245                 250                 255     


Ser Thr Ala Pro Ser Ser Gln Glu Thr Val Gln Pro Thr Ser Pro Ala 
            260                 265                 270         


Thr Ala Leu Arg Thr Pro Thr Leu Pro Glu Thr Met Ser Ser Ser Pro 
        275                 280                 285             


Thr Ala Ala Ser Thr Thr His Arg Tyr Pro Lys Thr Pro Ser Pro Thr 
    290                 295                 300                 


Val Ala His Glu Ser Asn Trp Val Thr Pro Ala Gly Val Gly Thr Gln 
305                 310                 315                 320 


Thr Arg Val Glu Glu Ala Leu Arg Gln Ala Leu Thr His Ser Leu Leu 
                325                 330                 335     


Pro Ala Gly Gly Ala Ser Asp Glu Lys Leu Ile Ser Leu Ile Cys Arg 
            340                 345                 350         


Ala Val Lys Ala Thr Phe Asn Pro Ala Gln Asp Lys Cys Gly Ile Arg 
        355                 360                 365             


Leu Ala Ser Val Pro Gly Ser Gln Thr Val Val Val Lys Glu Ile Thr 
    370                 375                 380                 


Ile His Thr Lys Leu Pro Ala Lys Asp Val Tyr Glu Arg Leu Lys Asp 
385                 390                 395                 400 


Lys Trp Asp Glu Leu Lys Glu Ala Gly Val Ser Asp Met Lys Leu Gly 
                405                 410                 415     


Asp Gln Gly Pro Pro Glu Glu Ala Glu Asp Arg Phe Ser Met Pro Leu 
            420                 425                 430         


Ile Ile Thr Ile Val Cys Met Ala Ser Phe Leu Leu Leu Val Ala Ala 
        435                 440                 445             


Leu Tyr Gly Cys Cys His Gln Arg Leu Ser Gln Arg Lys Asp Gln Gln 
    450                 455                 460                 


Arg Leu Thr Glu Glu Leu Gln Thr Val Glu Asn Gly Tyr His Asp Asn 
465                 470                 475                 480 


Pro Thr Leu Glu Val Met Glu Thr Ser Ser Glu Met Gln Glu Lys Lys 
                485                 490                 495     


Val Val Ser Leu Asn Gly Glu Leu Gly Asp Ser Trp Ile Val Pro Leu 
            500                 505                 510         


Asp Asn Leu Thr Lys Asp Asp Leu Asp Glu Glu Glu Asp Thr His Leu 
        515                 520                 525             


<210>  24
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Ala Lys Ser Gln Pro Asn Ile Pro Lys Ala Lys Ser Leu Asp 
1               5                   10                  15      


Gly Val Thr Asn Asp Arg Thr Ala Ser Gln Gly Gln Trp Gly Arg Ala 
            20                  25                  30          


Trp Glu Val Asp Trp Phe Ser Leu Ala Ser Val Ile Phe Leu Leu Leu 
        35                  40                  45              


Phe Ala Pro Phe Ile Val Tyr Tyr Phe Ile Met Ala Cys Asp Gln Tyr 
    50                  55                  60                  


Ser Cys Ala Leu Thr Gly Pro Val Val Asp Ile Val Thr Gly His Ala 
65                  70                  75                  80  


Arg Leu Ser Asp Ile Trp Ala Lys Thr Pro Pro Ile Thr Arg Lys Ala 
                85                  90                  95      


Ala Gln Leu Tyr Thr Leu Trp Val Thr Phe Gln Val Leu Leu Tyr Thr 
            100                 105                 110         


Ser Leu Pro Asp Phe Cys His Lys Phe Leu Pro Gly Tyr Val Gly Gly 
        115                 120                 125             


Ile Gln Glu Gly Ala Val Thr Pro Ala Gly Val Val Asn Lys Tyr Gln 
    130                 135                 140                 


Ile Asn Gly Leu Gln Ala Trp Leu Leu Thr His Leu Leu Trp Phe Ala 
145                 150                 155                 160 


Asn Ala His Leu Leu Ser Trp Phe Ser Pro Thr Ile Ile Phe Asp Asn 
                165                 170                 175     


Trp Ile Pro Leu Leu Trp Cys Ala Asn Ile Leu Gly Tyr Ala Val Ser 
            180                 185                 190         


Thr Phe Ala Met Val Lys Gly Tyr Phe Phe Pro Thr Ser Ala Arg Asp 
        195                 200                 205             


Cys Lys Phe Thr Gly Asn Phe Phe Tyr Asn Tyr Met Met Gly Ile Glu 
    210                 215                 220                 


Phe Asn Pro Arg Ile Gly Lys Trp Phe Asp Phe Lys Leu Phe Phe Asn 
225                 230                 235                 240 


Gly Arg Pro Gly Ile Val Ala Trp Thr Leu Ile Asn Leu Ser Phe Ala 
                245                 250                 255     


Ala Lys Gln Arg Glu Leu His Ser His Val Thr Asn Ala Met Val Leu 
            260                 265                 270         


Val Asn Val Leu Gln Ala Ile Tyr Val Ile Asp Phe Phe Trp Asn Glu 
        275                 280                 285             


Thr Trp Tyr Leu Lys Thr Ile Asp Ile Cys His Asp His Phe Gly Trp 
    290                 295                 300                 


Tyr Leu Gly Trp Gly Asp Cys Val Trp Leu Pro Tyr Leu Tyr Thr Leu 
305                 310                 315                 320 


Gln Gly Leu Tyr Leu Val Tyr His Pro Val Gln Leu Ser Thr Pro His 
                325                 330                 335     


Ala Val Gly Val Leu Leu Leu Gly Leu Val Gly Tyr Tyr Ile Phe Arg 
            340                 345                 350         


Val Ala Asn His Gln Lys Asp Leu Phe Arg Arg Thr Asp Gly Arg Cys 
        355                 360                 365             


Leu Ile Trp Gly Arg Lys Pro Lys Val Ile Glu Cys Ser Tyr Thr Ser 
    370                 375                 380                 


Ala Asp Gly Gln Arg His His Ser Lys Leu Leu Val Ser Gly Phe Trp 
385                 390                 395                 400 


Gly Val Ala Arg His Phe Asn Tyr Val Gly Asp Leu Met Gly Ser Leu 
                405                 410                 415     


Ala Tyr Cys Leu Ala Cys Gly Gly Gly His Leu Leu Pro Tyr Phe Tyr 
            420                 425                 430         


Ile Ile Tyr Met Ala Ile Leu Leu Thr His Arg Cys Leu Arg Asp Glu 
        435                 440                 445             


His Arg Cys Ala Ser Lys Tyr Gly Arg Asp Trp Glu Arg Tyr Thr Ala 
    450                 455                 460                 


Ala Val Pro Tyr Arg Leu Leu Pro Gly Ile Phe 
465                 470                 475 


<210>  25
<211>  1241
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ser Ser Ala Pro Arg Arg Pro Ala Lys Gly Ala Asp Ser Phe Cys 
1               5                   10                  15      


Thr Pro Glu Pro Glu Ser Leu Gly Pro Gly Thr Pro Gly Phe Pro Glu 
            20                  25                  30          


Gln Glu Glu Asp Glu Leu His Arg Thr Leu Gly Val Glu Arg Phe Glu 
        35                  40                  45              


Glu Ile Leu Gln Glu Ala Gly Ser Arg Gly Gly Glu Glu Pro Gly Arg 
    50                  55                  60                  


Ser Tyr Gly Glu Glu Asp Phe Glu Tyr His Arg Gln Ser Ser His His 
65                  70                  75                  80  


Ile His His Pro Leu Ser Thr His Leu Pro Pro Asp Ala Arg Arg Arg 
                85                  90                  95      


Lys Thr Pro Gln Gly Pro Gly Arg Lys Pro Arg Arg Arg Pro Gly Ala 
            100                 105                 110         


Ser Pro Thr Gly Glu Thr Pro Thr Ile Glu Glu Gly Glu Glu Asp Glu 
        115                 120                 125             


Asp Glu Ala Ser Glu Ala Glu Gly Ala Arg Ala Leu Thr Gln Pro Ser 
    130                 135                 140                 


Pro Val Ser Thr Pro Ser Ser Val Gln Phe Phe Leu Gln Glu Asp Asp 
145                 150                 155                 160 


Ser Ala Asp Arg Lys Ala Glu Arg Thr Ser Pro Ser Ser Pro Ala Pro 
                165                 170                 175     


Leu Pro His Gln Glu Ala Thr Pro Arg Ala Ser Lys Gly Ala Gln Ala 
            180                 185                 190         


Gly Thr Gln Val Glu Glu Ala Glu Ala Glu Ala Val Ala Val Ala Ser 
        195                 200                 205             


Gly Thr Ala Gly Gly Asp Asp Gly Gly Ala Ser Gly Arg Pro Leu Pro 
    210                 215                 220                 


Lys Ala Gln Pro Gly His Arg Ser Tyr Asn Leu Gln Glu Arg Arg Arg 
225                 230                 235                 240 


Ile Gly Ser Met Thr Gly Ala Glu Gln Ala Leu Leu Pro Arg Val Pro 
                245                 250                 255     


Thr Asp Glu Ile Glu Ala Gln Thr Leu Ala Thr Ala Asp Leu Asp Leu 
            260                 265                 270         


Met Lys Ser His Arg Phe Glu Asp Val Pro Gly Val Arg Arg His Leu 
        275                 280                 285             


Val Arg Lys Asn Ala Lys Gly Ser Thr Gln Ser Gly Arg Glu Gly Arg 
    290                 295                 300                 


Glu Pro Gly Pro Thr Pro Arg Ala Arg Pro Arg Ala Pro His Lys Pro 
305                 310                 315                 320 


His Glu Val Phe Val Glu Leu Asn Glu Leu Leu Leu Asp Lys Asn Gln 
                325                 330                 335     


Glu Pro Gln Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp 
            340                 345                 350         


Val Glu Glu Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu 
        355                 360                 365             


Ser Phe Arg Ser Leu Leu Glu Leu Arg Arg Thr Leu Ala His Gly Ala 
    370                 375                 380                 


Val Leu Leu Asp Leu Asp Gln Gln Thr Leu Pro Gly Val Ala His Gln 
385                 390                 395                 400 


Val Val Glu Gln Met Val Ile Ser Asp Gln Ile Lys Ala Glu Asp Arg 
                405                 410                 415     


Ala Asn Val Leu Arg Ala Leu Leu Leu Lys His Ser His Pro Ser Asp 
            420                 425                 430         


Glu Lys Asp Phe Ser Phe Pro Arg Asn Ile Ser Ala Gly Ser Leu Gly 
        435                 440                 445             


Ser Leu Leu Gly His His His Gly Gln Gly Ala Glu Ser Asp Pro His 
    450                 455                 460                 


Val Thr Glu Pro Leu Met Gly Gly Val Pro Glu Thr Arg Leu Glu Val 
465                 470                 475                 480 


Glu Arg Glu Arg Glu Leu Pro Pro Pro Ala Pro Pro Ala Gly Ile Thr 
                485                 490                 495     


Arg Ser Lys Ser Lys His Glu Leu Lys Leu Leu Glu Lys Ile Pro Glu 
            500                 505                 510         


Asn Ala Glu Ala Thr Val Val Leu Val Gly Cys Val Glu Phe Leu Ser 
        515                 520                 525             


Arg Pro Thr Met Ala Phe Val Arg Leu Arg Glu Ala Val Glu Leu Asp 
    530                 535                 540                 


Ala Val Leu Glu Val Pro Val Pro Val Arg Phe Leu Phe Leu Leu Leu 
545                 550                 555                 560 


Gly Pro Ser Ser Ala Asn Met Asp Tyr His Glu Ile Gly Arg Ser Ile 
                565                 570                 575     


Ser Thr Leu Met Ser Asp Lys Gln Phe His Glu Ala Ala Tyr Leu Ala 
            580                 585                 590         


Asp Glu Arg Glu Asp Leu Leu Thr Ala Ile Asn Ala Phe Leu Asp Cys 
        595                 600                 605             


Ser Val Val Leu Pro Pro Ser Glu Val Gln Gly Glu Glu Leu Leu Arg 
    610                 615                 620                 


Ser Val Ala His Phe Gln Arg Gln Met Leu Lys Lys Arg Glu Glu Gln 
625                 630                 635                 640 


Gly Arg Leu Leu Pro Thr Gly Ala Gly Leu Glu Pro Lys Ser Ala Gln 
                645                 650                 655     


Asp Lys Ala Leu Leu Gln Met Val Glu Ala Ala Gly Ala Ala Glu Asp 
            660                 665                 670         


Asp Pro Leu Arg Arg Thr Gly Arg Pro Phe Gly Gly Leu Ile Arg Asp 
        675                 680                 685             


Val Arg Arg Arg Tyr Pro His Tyr Leu Ser Asp Phe Arg Asp Ala Leu 
    690                 695                 700                 


Asp Pro Gln Cys Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala Leu 
705                 710                 715                 720 


Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Gln Asp 
                725                 730                 735     


Leu Ile Gly Val Ser Glu Leu Ile Met Ser Thr Ala Leu Gln Gly Val 
            740                 745                 750         


Val Phe Cys Leu Leu Gly Ala Gln Pro Leu Leu Val Ile Gly Phe Ser 
        755                 760                 765             


Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Ser Ser 
    770                 775                 780                 


Asn His Leu Glu Tyr Leu Val Gly Arg Val Trp Ile Gly Phe Trp Leu 
785                 790                 795                 800 


Val Phe Leu Ala Leu Leu Met Val Ala Leu Glu Gly Ser Phe Leu Val 
                805                 810                 815     


Arg Phe Val Ser Arg Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser 
            820                 825                 830         


Leu Ile Phe Ile Tyr Glu Thr Phe Tyr Lys Leu Val Lys Ile Phe Gln 
        835                 840                 845             


Glu His Pro Leu His Gly Cys Ser Ala Ser Asn Ser Ser Glu Val Asp 
    850                 855                 860                 


Gly Gly Glu Asn Met Thr Trp Ala Gly Ala Arg Pro Thr Leu Gly Pro 
865                 870                 875                 880 


Gly Asn Arg Ser Leu Ala Gly Gln Ser Gly Gln Gly Lys Pro Arg Gly 
                885                 890                 895     


Gln Pro Asn Thr Ala Leu Leu Ser Leu Val Leu Met Ala Gly Thr Phe 
            900                 905                 910         


Phe Ile Ala Phe Phe Leu Arg Lys Phe Lys Asn Ser Arg Phe Phe Pro 
        915                 920                 925             


Gly Arg Ile Arg Arg Val Ile Gly Asp Phe Gly Val Pro Ile Ala Ile 
    930                 935                 940                 


Leu Ile Met Val Leu Val Asp Tyr Ser Ile Glu Asp Thr Tyr Thr Gln 
945                 950                 955                 960 


Lys Leu Ser Val Pro Ser Gly Phe Ser Val Thr Ala Pro Glu Lys Arg 
                965                 970                 975     


Gly Trp Val Ile Asn Pro Leu Gly Glu Lys Ser Pro Phe Pro Val Trp 
            980                 985                 990         


Met Met Val Ala Ser Leu Leu Pro  Ala Ile Leu Val Phe  Ile Leu Ile 
        995                 1000                 1005             


Phe Met  Glu Thr Gln Ile Thr  Thr Leu Ile Ile Ser  Lys Lys Glu 
    1010                 1015                 1020             


Arg Met  Leu Gln Lys Gly Ser  Gly Phe His Leu Asp  Leu Leu Leu 
    1025                 1030                 1035             


Ile Val  Ala Met Gly Gly Ile  Cys Ala Leu Phe Gly  Leu Pro Trp 
    1040                 1045                 1050             


Leu Ala  Ala Ala Thr Val Arg  Ser Val Thr His Ala  Asn Ala Leu 
    1055                 1060                 1065             


Thr Val  Met Ser Lys Ala Val  Ala Pro Gly Asp Lys  Pro Lys Ile 
    1070                 1075                 1080             


Gln Glu  Val Lys Glu Gln Arg  Val Thr Gly Leu Leu  Val Ala Leu 
    1085                 1090                 1095             


Leu Val  Gly Leu Ser Ile Val  Ile Gly Asp Leu Leu  Arg Gln Ile 
    1100                 1105                 1110             


Pro Leu  Ala Val Leu Phe Gly  Ile Phe Leu Tyr Met  Gly Val Thr 
    1115                 1120                 1125             


Ser Leu  Asn Gly Ile Gln Phe  Tyr Glu Arg Leu His  Leu Leu Leu 
    1130                 1135                 1140             


Met Pro  Pro Lys His His Pro  Asp Val Thr Tyr Val  Lys Lys Val 
    1145                 1150                 1155             


Arg Thr  Leu Arg Met His Leu  Phe Thr Ala Leu Gln  Leu Leu Cys 
    1160                 1165                 1170             


Leu Ala  Leu Leu Trp Ala Val  Met Ser Thr Ala Ala  Ser Leu Ala 
    1175                 1180                 1185             


Phe Pro  Phe Ile Leu Ile Leu  Thr Val Pro Leu Arg  Met Val Val 
    1190                 1195                 1200             


Leu Thr  Arg Ile Phe Thr Asp  Arg Glu Met Lys Cys  Leu Asp Ala 
    1205                 1210                 1215             


Asn Glu  Ala Glu Pro Val Phe  Asp Glu Arg Glu Gly  Val Asp Glu 
    1220                 1225                 1230             


Tyr Asn  Glu Met Pro Met Pro  Val 
    1235                 1240     


<210>  26
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Lys Ser His Leu Ala Ile Val 
                405                 410                 415     


Gln Lys Val Asn Asn Glu Gly Glu Gly Asp Pro Phe Tyr Glu Val Leu 
            420                 425                 430         


Gly Leu Val Thr Leu Glu Asp Val Ile Glu Glu Ile Ile Arg Ser Glu 
        435                 440                 445             


Ile Leu Asp Glu Ser Glu Asp Tyr Arg Asp Thr Val Val Lys Arg Lys 
    450                 455                 460                 


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
465                 470                 475                 480 


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
                485                 490                 495     


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
            500                 505                 510         


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
        515                 520                 525             


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
    530                 535                 540                 


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
545                 550                 555                 560 


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
                565                 570                 575     


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
            580                 585                 590         


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
        595                 600                 605             


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
    610                 615                 620                 


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
625                 630                 635                 640 


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
                645                 650                 655     


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
            660                 665                 670         


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
        675                 680                 685             


Ser His Ser Arg Pro Gly Val Pro Val Glu Gly Ser Pro Gly Arg Asn 
    690                 695                 700                 


Pro Gly Val 
705         


<210>  27
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Val Arg Lys Pro Val Val Ser Thr Ile Ser Lys Gly Gly Tyr Leu 
1               5                   10                  15      


Gln Gly Asn Val Asn Gly Arg Leu Pro Ser Leu Gly Asn Lys Glu Pro 
            20                  25                  30          


Pro Gly Gln Glu Lys Val Gln Leu Lys Arg Lys Val Thr Leu Leu Arg 
        35                  40                  45              


Gly Val Ser Ile Ile Ile Gly Thr Ile Ile Gly Ala Gly Ile Phe Ile 
    50                  55                  60                  


Ser Pro Lys Gly Val Leu Gln Asn Thr Gly Ser Val Gly Met Ser Leu 
65                  70                  75                  80  


Thr Ile Trp Thr Val Cys Gly Val Leu Ser Leu Phe Gly Ala Leu Ser 
                85                  90                  95      


Tyr Ala Glu Leu Gly Thr Thr Ile Lys Lys Ser Gly Gly His Tyr Thr 
            100                 105                 110         


Tyr Ile Leu Glu Val Phe Gly Pro Leu Pro Ala Phe Val Arg Val Trp 
        115                 120                 125             


Val Glu Leu Leu Ile Ile Arg Pro Ala Ala Thr Ala Val Ile Ser Leu 
    130                 135                 140                 


Ala Phe Gly Arg Tyr Ile Leu Glu Pro Phe Phe Ile Gln Cys Glu Ile 
145                 150                 155                 160 


Pro Glu Leu Ala Ile Lys Leu Ile Thr Ala Val Gly Ile Thr Val Val 
                165                 170                 175     


Met Val Leu Asn Ser Met Ser Val Ser Trp Ser Ala Arg Ile Gln Ile 
            180                 185                 190         


Phe Leu Thr Phe Cys Lys Leu Thr Ala Ile Leu Ile Ile Ile Val Pro 
        195                 200                 205             


Gly Val Met Gln Leu Ile Lys Gly Gln Thr Gln Asn Phe Lys Asp Ala 
    210                 215                 220                 


Phe Ser Gly Arg Asp Ser Ser Ile Thr Arg Leu Pro Leu Ala Phe Tyr 
225                 230                 235                 240 


Tyr Gly Met Tyr Ala Tyr Ala Gly Trp Phe Tyr Leu Asn Phe Val Thr 
                245                 250                 255     


Glu Glu Val Glu Asn Pro Glu Lys Thr Ile Pro Leu Ala Ile Cys Ile 
            260                 265                 270         


Ser Met Ala Ile Val Thr Ile Gly Tyr Val Leu Thr Asn Val Ala Tyr 
        275                 280                 285             


Phe Thr Thr Ile Asn Ala Glu Glu Leu Leu Leu Ser Asn Ala Val Ala 
    290                 295                 300                 


Val Thr Phe Ser Glu Arg Leu Leu Gly Asn Phe Ser Leu Ala Val Pro 
305                 310                 315                 320 


Ile Phe Val Ala Leu Ser Cys Phe Gly Ser Met Asn Gly Gly Val Phe 
                325                 330                 335     


Ala Val Ser Arg Leu Phe Tyr Val Ala Ser Arg Glu Gly His Leu Pro 
            340                 345                 350         


Glu Ile Leu Ser Met Ile His Val Arg Lys His Thr Pro Leu Pro Ala 
        355                 360                 365             


Val Ile Val Leu His Pro Leu Thr Met Ile Met Leu Phe Ser Gly Asp 
    370                 375                 380                 


Leu Asp Ser Leu Leu Asn Phe Leu Ser Phe Ala Arg Trp Leu Phe Ile 
385                 390                 395                 400 


Gly Leu Ala Val Ala Gly Leu Ile Tyr Leu Arg Tyr Lys Cys Pro Asp 
                405                 410                 415     


Met His Arg Pro Phe Lys Val Pro Leu Phe Ile Pro Ala Leu Phe Ser 
            420                 425                 430         


Phe Thr Cys Leu Phe Met Val Ala Leu Ser Leu Tyr Ser Asp Pro Phe 
        435                 440                 445             


Ser Thr Gly Ile Gly Phe Val Ile Thr Leu Thr Gly Val Pro Ala Tyr 
    450                 455                 460                 


Tyr Leu Phe Ile Ile Trp Asp Lys Lys Pro Arg Trp Phe Arg Ile Met 
465                 470                 475                 480 


Ser Glu Lys Ile Thr Arg Thr Leu Gln Ile Ile Leu Glu Val Val Pro 
                485                 490                 495     


Glu Glu Asp Lys Leu 
            500     


<210>  28
<211>  905
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Asp Ser Thr Ala Cys Leu Lys Ser Leu Leu Leu Thr Val Ser Gln 
1               5                   10                  15      


Tyr Lys Ala Val Lys Ser Glu Ala Asn Ala Thr Gln Leu Leu Arg His 
            20                  25                  30          


Leu Glu Val Ile Ser Gly Gln Lys Leu Thr Arg Leu Phe Thr Ser Asn 
        35                  40                  45              


Gln Ile Leu Thr Ser Glu Cys Leu Ser Cys Leu Val Glu Leu Leu Glu 
    50                  55                  60                  


Asp Pro Asn Ile Ser Ala Ser Leu Ile Leu Ser Ile Ile Gly Leu Leu 
65                  70                  75                  80  


Ser Gln Leu Ala Val Asp Ile Glu Thr Arg Asp Cys Leu Gln Asn Thr 
                85                  90                  95      


Tyr Asn Leu Asn Ser Val Leu Ala Gly Val Val Cys Arg Ser Ser His 
            100                 105                 110         


Thr Asp Ser Val Phe Leu Gln Cys Ile Gln Leu Leu Gln Lys Leu Thr 
        115                 120                 125             


Tyr Asn Val Lys Ile Phe Tyr Ser Gly Ala Asn Ile Asp Glu Leu Ile 
    130                 135                 140                 


Thr Phe Leu Ile Asp His Ile Gln Ser Ser Glu Asp Glu Leu Lys Met 
145                 150                 155                 160 


Pro Cys Leu Gly Leu Leu Ala Asn Leu Cys Arg His Asn Leu Ser Val 
                165                 170                 175     


Gln Thr His Ile Lys Thr Leu Ser Asn Val Lys Ser Phe Tyr Arg Thr 
            180                 185                 190         


Leu Ile Thr Leu Leu Ala His Ser Ser Leu Thr Val Val Val Phe Ala 
        195                 200                 205             


Leu Ser Ile Leu Ser Ser Leu Thr Leu Asn Glu Glu Val Gly Glu Lys 
    210                 215                 220                 


Leu Phe His Ala Arg Asn Ile His Gln Thr Phe Gln Leu Ile Phe Asn 
225                 230                 235                 240 


Ile Leu Ile Asn Gly Asp Gly Thr Leu Thr Arg Lys Tyr Ser Val Asp 
                245                 250                 255     


Leu Leu Met Asp Leu Leu Lys Asn Pro Lys Ile Ala Asp Tyr Leu Thr 
            260                 265                 270         


Arg Tyr Glu His Phe Ser Ser Cys Leu His Gln Val Leu Gly Leu Leu 
        275                 280                 285             


Asn Gly Lys Asp Pro Asp Ser Ser Ser Lys Val Leu Glu Leu Leu Leu 
    290                 295                 300                 


Ala Phe Cys Ser Val Thr Gln Leu Arg His Met Leu Thr Gln Met Met 
305                 310                 315                 320 


Phe Glu Gln Ser Pro Pro Gly Ser Ala Thr Leu Gly Ser His Thr Lys 
                325                 330                 335     


Cys Leu Glu Pro Thr Val Ala Leu Leu Arg Trp Leu Ser Gln Pro Leu 
            340                 345                 350         


Asp Gly Ser Glu Asn Cys Ser Val Leu Ala Leu Glu Leu Phe Lys Glu 
        355                 360                 365             


Ile Phe Glu Asp Val Ile Asp Ala Ala Asn Cys Ser Ser Ala Asp Arg 
    370                 375                 380                 


Phe Val Thr Leu Leu Leu Pro Thr Ile Leu Asp Gln Leu Gln Phe Thr 
385                 390                 395                 400 


Glu Gln Asn Leu Asp Glu Ala Leu Thr Arg Lys Lys Cys Glu Arg Ile 
                405                 410                 415     


Ala Lys Ala Ile Glu Val Leu Leu Thr Leu Cys Gly Asp Asp Thr Leu 
            420                 425                 430         


Lys Met His Ile Ala Lys Ile Leu Thr Thr Val Lys Cys Thr Thr Leu 
        435                 440                 445             


Ile Glu Gln Gln Phe Thr Tyr Gly Lys Ile Asp Leu Gly Phe Gly Thr 
    450                 455                 460                 


Lys Val Ala Asp Ser Glu Leu Cys Lys Leu Ala Ala Asp Val Ile Leu 
465                 470                 475                 480 


Lys Thr Leu Asp Leu Ile Asn Lys Leu Lys Pro Leu Val Pro Gly Met 
                485                 490                 495     


Glu Val Ser Phe Tyr Lys Ile Leu Gln Asp Pro Arg Leu Ile Thr Pro 
            500                 505                 510         


Leu Ala Phe Ala Leu Thr Ser Asp Asn Arg Glu Gln Val Gln Ser Gly 
        515                 520                 525             


Leu Arg Ile Leu Leu Glu Ala Ala Pro Leu Pro Asp Phe Pro Ala Leu 
    530                 535                 540                 


Val Leu Gly Glu Ser Ile Ala Ala Asn Asn Ala Tyr Arg Gln Gln Glu 
545                 550                 555                 560 


Thr Glu His Ile Pro Arg Lys Met Pro Trp Gln Ser Ser Asn His Ser 
                565                 570                 575     


Phe Pro Thr Ser Ile Lys Cys Leu Thr Pro His Leu Lys Asp Gly Val 
            580                 585                 590         


Pro Gly Leu Asn Ile Glu Glu Leu Ile Glu Lys Leu Gln Ser Gly Met 
        595                 600                 605             


Val Val Lys Asp Gln Ile Cys Asp Val Arg Ile Ser Asp Ile Met Asp 
    610                 615                 620                 


Val Tyr Glu Met Lys Leu Ser Thr Leu Ala Ser Lys Glu Ser Arg Leu 
625                 630                 635                 640 


Gln Asp Leu Leu Glu Thr Lys Ala Leu Ala Leu Ala Gln Ala Asp Arg 
                645                 650                 655     


Leu Ile Ala Gln His Arg Cys Gln Arg Thr Gln Ala Glu Thr Glu Ala 
            660                 665                 670         


Arg Thr Leu Ala Ser Met Leu Arg Glu Val Glu Arg Lys Asn Glu Glu 
        675                 680                 685             


Leu Ser Val Leu Leu Lys Ala Gln Gln Val Glu Ser Glu Arg Ala Gln 
    690                 695                 700                 


Ser Asp Ile Glu His Leu Phe Gln His Asn Arg Lys Leu Glu Ser Val 
705                 710                 715                 720 


Ala Glu Glu His Glu Ile Leu Thr Lys Ser Tyr Met Glu Leu Leu Gln 
                725                 730                 735     


Arg Asn Glu Ser Thr Glu Lys Lys Asn Lys Asp Leu Gln Ile Thr Cys 
            740                 745                 750         


Asp Ser Leu Asn Lys Gln Ile Glu Thr Val Lys Lys Leu Asn Glu Ser 
        755                 760                 765             


Leu Lys Glu Gln Asn Glu Lys Ser Ile Ala Gln Leu Ile Glu Lys Glu 
    770                 775                 780                 


Glu Gln Arg Lys Glu Val Gln Asn Gln Leu Val Asp Arg Glu His Lys 
785                 790                 795                 800 


Leu Ala Asn Leu His Gln Lys Thr Lys Val Gln Glu Glu Lys Ile Lys 
                805                 810                 815     


Thr Leu Gln Lys Glu Arg Glu Asp Lys Glu Glu Thr Ile Asp Ile Leu 
            820                 825                 830         


Arg Lys Glu Leu Ser Arg Thr Glu Gln Ile Arg Lys Glu Leu Ser Ile 
        835                 840                 845             


Lys Ala Ser Ser Leu Glu Val Gln Lys Ala Gln Leu Glu Gly Arg Leu 
    850                 855                 860                 


Glu Glu Lys Glu Ser Leu Val Lys Leu Gln Gln Glu Glu Leu Asn Lys 
865                 870                 875                 880 


His Ser His Met Ile Ala Met Ile His Ser Leu Ser Gly Gly Lys Ile 
                885                 890                 895     


Asn Pro Glu Thr Val Asn Leu Ser Ile 
            900                 905 


<210>  29
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Leu Pro Ser Gly Pro Gly Pro Glu Arg Leu Phe Asp Ser His 
1               5                   10                  15      


Arg Leu Pro Gly Asp Cys Phe Leu Leu Leu Val Leu Leu Leu Tyr Ala 
            20                  25                  30          


Pro Val Gly Phe Cys Leu Leu Val Leu Arg Leu Phe Leu Gly Ile His 
        35                  40                  45              


Val Phe Leu Val Ser Cys Ala Leu Pro Asp Ser Val Leu Arg Arg Phe 
    50                  55                  60                  


Val Val Arg Thr Met Cys Ala Val Leu Gly Leu Val Ala Arg Gln Glu 
65                  70                  75                  80  


Asp Ser Gly Leu Arg Asp His Ser Val Arg Val Leu Ile Ser Asn His 
                85                  90                  95      


Val Thr Pro Phe Asp His Asn Ile Val Asn Leu Leu Thr Thr Cys Ser 
            100                 105                 110         


Thr Val Ser Glu Ser Glu Ala Glu Ser Ala Thr Gly Arg Phe Pro Gly 
        115                 120                 125             


Ala Gln Leu Lys Ala Pro Leu Ser Pro Leu Ala Phe Pro Met Glu Asp 
    130                 135                 140                 


Thr Glu Leu Pro Leu Thr Pro Ile Leu Tyr Pro Thr Cys Gln Phe Phe 
145                 150                 155                 160 


Phe Ile Phe Leu Asn Ile Phe Leu Leu Ala Phe Ser Ser Pro Gly Ser 
                165                 170                 175     


Gln Pro Leu Leu Asn Ser Pro Pro Ser Phe Val Cys Trp Ser Arg Gly 
            180                 185                 190         


Phe Met Glu Met Asn Gly Arg Gly Glu Leu Val Glu Ser Leu Lys Arg 
        195                 200                 205             


Phe Cys Ala Ser Thr Arg Leu Pro Pro Thr Pro Leu Leu Leu Phe Pro 
    210                 215                 220                 


Glu Glu Glu Ala Thr Asn Gly Arg Glu Gly Leu Leu Arg Phe Ser Ser 
225                 230                 235                 240 


Trp Pro Phe Ser Ile Gln Asp Val Val Gln Pro Leu Thr Leu Gln Val 
                245                 250                 255     


Gln Arg Pro Leu Val Ser Val Thr Val Ser Asp Ala Ser Trp Val Ser 
            260                 265                 270         


Glu Leu Leu Trp Ser Leu Phe Val Pro Phe Thr Val Tyr Gln Val Arg 
        275                 280                 285             


Trp Leu Arg Pro Val His Arg Gln Leu Gly Glu Ala Asn Glu Glu Phe 
    290                 295                 300                 


Ala Leu Arg Val Gln Gln Leu Val Ala Lys Glu Leu Gly Gln Thr Gly 
305                 310                 315                 320 


Thr Arg Leu Thr Pro Ala Asp Lys Ala Glu His Met Lys Arg Gln Arg 
                325                 330                 335     


His Pro Arg Leu Arg Pro Gln Ser Ala Gln Ser Ser Phe Pro Pro Ser 
            340                 345                 350         


Pro Gly Pro Ser Pro Asp Val Gln Leu Ala Thr Leu Ala Gln Arg Val 
        355                 360                 365             


Lys Glu Val Leu Pro His Val Pro Leu Gly Val Ile Gln Arg Asp Leu 
    370                 375                 380                 


Ala Lys Thr Gly Cys Val Asp Leu Thr Ile Thr Asn Leu Leu Glu Gly 
385                 390                 395                 400 


Ala Val Ala Phe Met Pro Glu Asp Ile Thr Lys Gly Thr Gln Ser Leu 
                405                 410                 415     


Pro Thr Ala Ser Ala Ser Lys Phe Pro Ser Ser Gly Pro Val Thr Pro 
            420                 425                 430         


Gln Pro Thr Ala Leu Thr Phe Ala Lys Ser Ser Trp Ala Arg Gln Glu 
        435                 440                 445             


Ser Leu Gln Glu Arg Lys Gln Ala Leu Tyr Glu Tyr Ala Arg Arg Arg 
    450                 455                 460                 


Phe Thr Glu Arg Arg Ala Gln Glu Ala Asp 
465                 470                 


<210>  30
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Glu Lys Ser Asn Glu Thr Asn Gly Tyr Leu Asp Ser Ala Gln Ala 
1               5                   10                  15      


Gly Pro Ala Ala Gly Pro Gly Ala Pro Gly Thr Ala Ala Gly Arg Ala 
            20                  25                  30          


Arg Arg Cys Ala Gly Phe Leu Arg Arg Gln Ala Leu Val Leu Leu Thr 
        35                  40                  45              


Val Ser Gly Val Leu Ala Gly Ala Gly Leu Gly Ala Ala Leu Arg Gly 
    50                  55                  60                  


Leu Ser Leu Ser Arg Thr Gln Val Thr Tyr Leu Ala Phe Pro Gly Glu 
65                  70                  75                  80  


Met Leu Leu Arg Met Leu Arg Met Ile Ile Leu Pro Leu Val Val Cys 
                85                  90                  95      


Ser Leu Val Ser Gly Ala Ala Ser Leu Asp Ala Ser Cys Leu Gly Arg 
            100                 105                 110         


Leu Gly Gly Ile Ala Val Ala Tyr Phe Gly Leu Thr Thr Leu Ser Ala 
        115                 120                 125             


Ser Ala Leu Ala Val Ala Leu Ala Phe Ile Ile Lys Pro Gly Ser Gly 
    130                 135                 140                 


Ala Gln Thr Leu Gln Ser Ser Asp Leu Gly Leu Glu Asp Ser Gly Pro 
145                 150                 155                 160 


Pro Pro Val Pro Lys Glu Thr Val Asp Ser Phe Leu Asp Leu Ala Arg 
                165                 170                 175     


Asn Leu Phe Pro Ser Asn Leu Val Val Ala Ala Phe Arg Thr Tyr Ala 
            180                 185                 190         


Thr Asp Tyr Lys Val Val Thr Gln Asn Ser Ser Ser Gly Asn Val Thr 
        195                 200                 205             


His Glu Lys Ile Pro Ile Gly Thr Glu Ile Glu Gly Met Asn Ile Leu 
    210                 215                 220                 


Gly Leu Val Leu Phe Ala Leu Val Leu Gly Val Ala Leu Lys Lys Leu 
225                 230                 235                 240 


Gly Ser Glu Gly Glu Asp Leu Ile Arg Phe Phe Asn Ser Leu Asn Glu 
                245                 250                 255     


Ala Thr Met Val Leu Val Ser Trp Ile Met Trp Tyr Val Pro Val Gly 
            260                 265                 270         


Ile Met Phe Leu Val Gly Ser Lys Ile Val Glu Met Lys Asp Ile Ile 
        275                 280                 285             


Val Leu Val Thr Ser Leu Gly Lys Tyr Ile Phe Ala Ser Ile Leu Gly 
    290                 295                 300                 


His Val Ile His Gly Gly Ile Val Leu Pro Leu Ile Tyr Phe Val Phe 
305                 310                 315                 320 


Thr Arg Lys Asn Pro Phe Arg Phe Leu Leu Gly Leu Leu Ala Pro Phe 
                325                 330                 335     


Ala Thr Ala Phe Ala Thr Cys Ser Ser Ser Ala Thr Leu Pro Ser Met 
            340                 345                 350         


Met Lys Cys Ile Glu Glu Asn Asn Gly Val Asp Lys Arg Ile Ser Arg 
        355                 360                 365             


Phe Ile Leu Pro Ile Gly Ala Thr Val Asn Met Asp Gly Ala Ala Ile 
    370                 375                 380                 


Phe Gln Cys Val Ala Ala Val Phe Ile Ala Gln Leu Asn Asn Val Glu 
385                 390                 395                 400 


Leu Asn Ala Gly Gln Ile Phe Thr Ile Leu Val Thr Ala Thr Ala Ser 
                405                 410                 415     


Ser Val Gly Ala Ala Gly Val Pro Ala Gly Gly Val Leu Thr Ile Ala 
            420                 425                 430         


Ile Ile Leu Glu Ala Ile Gly Leu Pro Thr His Asp Leu Pro Leu Ile 
        435                 440                 445             


Leu Ala Val Asp Trp Ile Val Asp Arg Thr Thr Thr Val Val Asn Val 
    450                 455                 460                 


Glu Gly Asp Ala Leu Gly Ala Gly Ile Leu His His Leu Asn Gln Lys 
465                 470                 475                 480 


Ala Thr Lys Lys Gly Glu Gln Glu Leu Ala Glu Val Lys Val Glu Ala 
                485                 490                 495     


Ile Pro Asn Cys Lys Ser Glu Glu Glu Thr Ser Pro Leu Val Thr His 
            500                 505                 510         


Gln Asn Pro Ala Gly Pro Val Ala Ser Ala Pro Glu Leu Glu Ser Lys 
        515                 520                 525             


Glu Ser Val Leu 
    530         


<210>  31
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Lys Lys Met Ser Arg Asn Val Leu Leu Gln Met Glu Glu Glu Glu 
1               5                   10                  15      


Asp Asp Asp Asp Gly Asp Ile Val Leu Glu Asn Leu Gly Gln Thr Ile 
            20                  25                  30          


Val Pro Asp Leu Gly Ser Leu Glu Ser Gln His Asp Phe Arg Thr Pro 
        35                  40                  45              


Glu Phe Glu Glu Phe Asn Gly Lys Pro Asp Ser Leu Phe Phe Asn Asp 
    50                  55                  60                  


Gly Gln Arg Arg Ile Asp Phe Val Leu Val Tyr Glu Asp Glu Ser Arg 
65                  70                  75                  80  


Lys Glu Thr Asn Lys Lys Gly Thr Asn Glu Lys Gln Arg Arg Lys Arg 
                85                  90                  95      


Gln Ala Tyr Glu Ser Asn Leu Ile Cys His Gly Leu Gln Leu Glu Ala 
            100                 105                 110         


Thr Arg Ser Val Leu Asp Asp Lys Leu Val Phe Val Lys Val His Ala 
        115                 120                 125             


Pro Trp Glu Val Leu Cys Thr Tyr Ala Glu Ile Met His Ile Lys Leu 
    130                 135                 140                 


Pro Leu Lys Pro Asn Asp Leu Lys Asn Arg Ser Ser Ala Phe Gly Thr 
145                 150                 155                 160 


Leu Asn Trp Phe Thr Lys Val Leu Ser Val Asp Glu Ser Ile Ile Lys 
                165                 170                 175     


Pro Glu Gln Glu Phe Phe Thr Ala Pro Phe Glu Lys Asn Arg Met Asn 
            180                 185                 190         


Asp Phe Tyr Ile Val Asp Arg Asp Ala Phe Phe Asn Pro Ala Thr Arg 
        195                 200                 205             


Ser Arg Ile Val Tyr Phe Ile Leu Ser Arg Val Lys Tyr Gln Val Ile 
    210                 215                 220                 


Asn Asn Val Ser Lys Phe Gly Ile Asn Arg Leu Val Asn Ser Gly Ile 
225                 230                 235                 240 


Tyr Lys Ala Ala Phe Pro Leu His Asp Cys Lys Phe Arg Arg Gln Ser 
                245                 250                 255     


Glu Asp Pro Ser Cys Pro Asn Glu Arg Tyr Leu Leu Tyr Arg Glu Trp 
            260                 265                 270         


Ala His Pro Arg Ser Ile Tyr Lys Lys Gln Pro Leu Asp Leu Ile Arg 
        275                 280                 285             


Lys Tyr Tyr Gly Glu Lys Ile Gly Ile Tyr Phe Ala Trp Leu Gly Tyr 
    290                 295                 300                 


Tyr Thr Gln Met Leu Leu Leu Ala Ala Val Val Gly Val Ala Cys Phe 
305                 310                 315                 320 


Leu Tyr Gly Tyr Leu Asn Gln Asp Asn Cys Thr Trp Ser Lys Glu Val 
                325                 330                 335     


Cys His Pro Asp Ile Gly Gly Lys Ile Ile Met Cys Pro Gln Cys Asp 
            340                 345                 350         


Arg Leu Cys Pro Phe Trp Lys Leu Asn Ile Thr Cys Glu Ser Ser Lys 
        355                 360                 365             


Lys Leu Cys Ile Phe Asp Ser Phe Gly Thr Leu Val Phe Ala Val Phe 
    370                 375                 380                 


Met Gly Val Trp Val Thr Leu Phe Leu Glu Phe Trp Lys Arg Arg Gln 
385                 390                 395                 400 


Ala Glu Leu Glu Tyr Glu Trp Asp Thr Val Glu Leu Gln Gln Glu Glu 
                405                 410                 415     


Gln Ala Arg Pro Glu Tyr Glu Ala Arg Cys Thr His Val Val Ile Asn 
            420                 425                 430         


Glu Ile Thr Gln Glu Glu Glu Arg Ile Pro Phe Thr Ala Trp Gly Lys 
        435                 440                 445             


Cys Ile Arg Ile Thr Leu Cys Ala Ser Ala Val Phe Phe Trp Ile Leu 
    450                 455                 460                 


Leu Ile Ile Ala Ser Val Ile Gly Ile Ile Val Tyr Arg Leu Ser Val 
465                 470                 475                 480 


Phe Ile Val Phe Ser Ala Lys Leu Pro Lys Asn Ile Asn Gly Thr Asp 
                485                 490                 495     


Pro Ile Gln Lys Tyr Leu Thr Pro Gln Thr Ala Thr Ser Ile Thr Ala 
            500                 505                 510         


Ser Ile Ile Ser Phe Ile Ile Ile Met Ile Leu Asn Thr Ile Tyr Glu 
        515                 520                 525             


Lys Val Ala Ile Met Ile Thr Asn Phe Glu Leu Pro Arg Thr Gln Thr 
    530                 535                 540                 


Asp Tyr Glu Asn Ser Leu Thr Met Lys Met Phe Leu Phe Gln Phe Val 
545                 550                 555                 560 


Asn Tyr Tyr Ser Ser Cys Phe Tyr Ile Ala Phe Phe Lys Gly Lys Phe 
                565                 570                 575     


Val Gly Tyr Pro Gly Asp Pro Val Tyr Trp Leu Gly Lys Tyr Arg Asn 
            580                 585                 590         


Glu Glu Cys Asp Pro Gly Gly Cys Leu Leu Glu Leu Thr Thr Gln Leu 
        595                 600                 605             


Thr Ile Ile Met Gly Gly Lys Ala Ile Trp Asn Asn Ile Gln Glu Val 
    610                 615                 620                 


Leu Leu Pro Trp Ile Met Asn Leu Ile Gly Arg Phe His Arg Val Ser 
625                 630                 635                 640 


Gly Ser Glu Lys Ile Thr Pro Arg Trp Glu Gln Asp Tyr His Leu Gln 
                645                 650                 655     


Pro Met Gly Lys Leu Gly Leu Phe Tyr Glu Tyr Leu Glu Met Ile Ile 
            660                 665                 670         


Gln Phe Gly Phe Val Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro 
        675                 680                 685             


Leu Leu Ala Leu Val Asn Asn Ile Leu Glu Ile Arg Val Asp Ala Trp 
    690                 695                 700                 


Lys Leu Thr Thr Gln Phe Arg Arg Leu Val Pro Glu Lys Ala Gln Asp 
705                 710                 715                 720 


Ile Gly Ala Trp Gln Pro Ile Met Gln Gly Ile Ala Ile Leu Ala Val 
                725                 730                 735     


Val Thr Asn Ala Met Ile Ile Ala Phe Thr Ser Asp Met Ile Pro Arg 
            740                 745                 750         


Leu Val Tyr Tyr Trp Ser Phe Ser Val Pro Pro Tyr Gly Asp His Thr 
        755                 760                 765             


Ser Tyr Thr Met Glu Gly Tyr Ile Asn Asn Thr Leu Ser Ile Phe Lys 
    770                 775                 780                 


Val Ala Asp Phe Lys Asn Lys Ser Lys Gly Asn Pro Tyr Ser Asp Leu 
785                 790                 795                 800 


Gly Asn His Thr Thr Cys Arg Tyr Arg Asp Phe Arg Tyr Pro Pro Gly 
                805                 810                 815     


His Pro Gln Glu Tyr Lys His Asn Ile Tyr Tyr Trp His Val Ile Ala 
            820                 825                 830         


Ala Lys Leu Ala Phe Ile Ile Val Met Glu His Val Ile Tyr Ser Val 
        835                 840                 845             


Lys Phe Phe Ile Ser Tyr Ala Ile Pro Asp Val Ser Lys Arg Thr Lys 
    850                 855                 860                 


Ser Lys Ile Gln Arg Glu Lys Tyr Leu Thr Gln Lys Leu Leu His Glu 
865                 870                 875                 880 


Asn His Leu Lys Asp Met Thr Lys Asn Met Gly Val Ile Ala Glu Arg 
                885                 890                 895     


Met Ile Glu Ala Val Asp Asn Asn Leu Arg Pro Lys Ser Glu 
            900                 905                 910 


<210>  32
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Arg Gly Arg Val Val Arg Val Pro Thr Ala Thr Leu Val 
            20                  25                  30          


Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr 
        35                  40                  45              


Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly 
    50                  55                  60                  


Ser Ser Phe Val Glu Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala 
65                  70                  75                  80  


Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg 
                85                  90                  95      


Thr Ala Asn Asp Ala Val Glu Leu His Ile Lys Asn Val Gln Pro Ser 
            100                 105                 110         


Asp Gln Gly His Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val 
        115                 120                 125             


Gln Gly Asn Tyr Glu Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser 
    130                 135                 140                 


Leu His Val Gly Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg 
145                 150                 155                 160 


Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro 
                165                 170                 175     


Leu His Thr His Leu Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala 
            180                 185                 190         


Arg Arg Ser Val Leu Ala Leu Thr His Glu Gly Arg Phe His Pro Gly 
        195                 200                 205             


Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr 
    210                 215                 220                 


Val Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala 
225                 230                 235                 240 


Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln 
                245                 250                 255     


Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val 
            260                 265                 270         


Val Ile Gln Pro Ser Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser 
        275                 280                 285             


Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp 
    290                 295                 300                 


Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met 
305                 310                 315                 320 


Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg 
                325                 330                 335     


Asp Ser Leu Val His Ser Ser Pro His Val Ala Leu Ser His Val Asp 
            340                 345                 350         


Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser 
        355                 360                 365             


Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala Pro Gly His Asn Arg 
    370                 375                 380                 


Ser Trp His Lys Val Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly 
385                 390                 395                 400 


Val Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys 
                405                 410                 415     


Val Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val 
            420                 425                 430         


Asp Thr Lys Ser Gly Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr 
        435                 440                 445             


Tyr Arg Met Asn Arg Arg Ser Asp Asn Val Val Thr Ser Glu Leu Leu 
    450                 455                 460                 


Ala Val Met Asp Gly Asp Trp Thr Leu Lys Tyr Gly Glu Arg Ser Lys 
465                 470                 475                 480 


Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser Lys Glu His Thr Asp 
                485                 490                 495     


Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu Glu Asp Arg Gly Asn 
            500                 505                 510         


Tyr Tyr Cys Val Val Ser Ala Trp Thr Lys Gln Arg Asn Asn Ser Trp 
        515                 520                 525             


Val Lys Ser Lys Asp Val Phe Ser Lys Pro Val Asn Ile Phe Trp Ala 
    530                 535                 540                 


Leu Glu Asp Ser Val Leu Val Val Lys Ala Arg Gln Pro Lys Pro Phe 
545                 550                 555                 560 


Phe Ala Ala Gly Asn Thr Phe Glu Met Thr Cys Lys Val Ser Ser Lys 
                565                 570                 575     


Asn Ile Lys Ser Pro Arg Tyr Ser Val Leu Ile Met Ala Glu Lys Pro 
            580                 585                 590         


Val Gly Asp Leu Ser Ser Pro Asn Glu Thr Lys Tyr Ile Ile Ser Leu 
        595                 600                 605             


Asp Gln Asp Ser Val Val Lys Leu Glu Asn Trp Thr Asp Ala Ser Arg 
    610                 615                 620                 


Val Asp Gly Val Val Leu Glu Lys Val Gln Glu Asp Glu Phe Arg Tyr 
625                 630                 635                 640 


Arg Met Tyr Gln Thr Gln Val Ser Asp Ala Gly Leu Tyr Arg Cys Met 
                645                 650                 655     


Val Thr Ala Trp Ser Pro Val Arg Gly Ser Leu Trp Arg Glu Ala Ala 
            660                 665                 670         


Thr Ser Leu Ser Asn Pro Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro 
        675                 680                 685             


Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser Val Ile Arg Gly 
    690                 695                 700                 


Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu Gly Ala Ala Leu 
705                 710                 715                 720 


Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe Ala Val His Ser 
                725                 730                 735     


Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser Leu Asp Arg Lys 
            740                 745                 750         


Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu 
        755                 760                 765             


Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val His Gly Ser Glu 
    770                 775                 780                 


Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys 
785                 790                 795                 800 


Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile His Ser Lys Pro 
                805                 810                 815     


Val Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala Phe Lys Tyr Pro 
            820                 825                 830         


Leu Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly Leu Leu Ser Cys 
        835                 840                 845             


Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys Lys Glu Val Gln 
    850                 855                 860                 


Glu Thr Arg Arg Glu Arg Arg Arg Leu Met Ser Met Glu Met Asp 
865                 870                 875                 


