                         SEQUENCE LISTING

<110>  LEINWAND, LESLIE A.
       RIQUELME, CECILIA
 
<120>  METHODS AND COMPOSITIONS INVOLVING AQUAPORIN 7

<130>  HIBE:003WO

<140>  UNKNOWN
<141>  2010-04-09

<150>  61/168,060
<151>  2009-04-09

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  1258
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (173)..(1201)

<400>  1
ggctctggac tggggacaca gggatagctg agccccagct gggggtggaa gctgagccag       60

ggacagtcac ggaggaacaa gatcaagatg cgctgtaact gagaagcccc caaggcggag      120

gctgagaatc agagacattt cagcagacat ctacaaatct gaaagacaaa ac atg gtt      178
                                                          Met Val         
                                                          1               

caa gca tcc ggg cac agg cgg tcc acc cgt ggc tcc aaa atg gtc tcc        226
Gln Ala Ser Gly His Arg Arg Ser Thr Arg Gly Ser Lys Met Val Ser           
        5                   10                  15                        

tgg tcc gtg ata gca aag atc cag gaa ata ctg cag agg aag atg gtg        274
Trp Ser Val Ile Ala Lys Ile Gln Glu Ile Leu Gln Arg Lys Met Val           
    20                  25                  30                            

cga gag ttc ctg gcc gag ttc atg agc aca tat gtc atg atg gta ttc        322
Arg Glu Phe Leu Ala Glu Phe Met Ser Thr Tyr Val Met Met Val Phe           
35                  40                  45                  50            

ggc ctt ggt tcc gtg gcc cat atg gtt cta aat aaa aaa tat ggg agc        370
Gly Leu Gly Ser Val Ala His Met Val Leu Asn Lys Lys Tyr Gly Ser           
                55                  60                  65                

tac ctt ggt gtc aac ttg ggt ttt ggc ttc gga gtc acc atg gga gtg        418
Tyr Leu Gly Val Asn Leu Gly Phe Gly Phe Gly Val Thr Met Gly Val           
            70                  75                  80                    

cac gtg gca ggc cgc atc tct gga gcc cac atg aac gca gct gtg acc        466
His Val Ala Gly Arg Ile Ser Gly Ala His Met Asn Ala Ala Val Thr           
        85                  90                  95                        

ttt gct aac tgt gcg ctg ggc cgc gtg ccc tgg agg aag ttt ccg gtc        514
Phe Ala Asn Cys Ala Leu Gly Arg Val Pro Trp Arg Lys Phe Pro Val           
    100                 105                 110                           

tat gtg ctg ggg cag ttc ctg ggc tcc ttc ctg gcg gct gcc acc atc        562
Tyr Val Leu Gly Gln Phe Leu Gly Ser Phe Leu Ala Ala Ala Thr Ile           
115                 120                 125                 130           

tac agt ctc ttc tac acg gcc att ctc cac ttt tcg ggt gga cag ctg        610
Tyr Ser Leu Phe Tyr Thr Ala Ile Leu His Phe Ser Gly Gly Gln Leu           
                135                 140                 145               

atg gtg acc ggt ccc gtc gct aca gct ggc att ttt gcc acc tac ctt        658
Met Val Thr Gly Pro Val Ala Thr Ala Gly Ile Phe Ala Thr Tyr Leu           
            150                 155                 160                   

cct gat cac atg aca ttg tgg cgg ggc ttc ctg aat gag gcg tgg ctg        706
Pro Asp His Met Thr Leu Trp Arg Gly Phe Leu Asn Glu Ala Trp Leu           
        165                 170                 175                       

acc ggg atg ctc cag ctg tgt ctc ttc gcc atc acg gac cag gag aac        754
Thr Gly Met Leu Gln Leu Cys Leu Phe Ala Ile Thr Asp Gln Glu Asn           
    180                 185                 190                           

aac cca gca ctg cca gga aca gag gcg ctg gtg ata ggc atc ctc gtg        802
Asn Pro Ala Leu Pro Gly Thr Glu Ala Leu Val Ile Gly Ile Leu Val           
195                 200                 205                 210           

gtc atc atc ggg gtg tcc ctt ggc atg aac aca gga tat gcc atc aac        850
Val Ile Ile Gly Val Ser Leu Gly Met Asn Thr Gly Tyr Ala Ile Asn           
                215                 220                 225               

ccg tcc cgg gac ctg ccc ccc cgc atc ttc acc ttc att gct ggt tgg        898
Pro Ser Arg Asp Leu Pro Pro Arg Ile Phe Thr Phe Ile Ala Gly Trp           
            230                 235                 240                   

ggc aaa cag gtc ttc agc aat ggg gag aac tgg tgg tgg gtg cca gtg        946
Gly Lys Gln Val Phe Ser Asn Gly Glu Asn Trp Trp Trp Val Pro Val           
        245                 250                 255                       

gtg gca cca ctt ctg ggt gcc tat cta ggt ggc atc atc tac ctg gtc        994
Val Ala Pro Leu Leu Gly Ala Tyr Leu Gly Gly Ile Ile Tyr Leu Val           
    260                 265                 270                           

ttc att ggc tcc acc atc cca cgg gag ccc ctg aaa ttg gag gat tct       1042
Phe Ile Gly Ser Thr Ile Pro Arg Glu Pro Leu Lys Leu Glu Asp Ser           
275                 280                 285                 290           

gtg gcg tat gaa gac cac ggg ata acc gta ttg ccc aag atg gga tct       1090
Val Ala Tyr Glu Asp His Gly Ile Thr Val Leu Pro Lys Met Gly Ser           
                295                 300                 305               

cat gaa ccc acg atc tct ccc ctc acc ccc gtc tct gtg agc cct gcc       1138
His Glu Pro Thr Ile Ser Pro Leu Thr Pro Val Ser Val Ser Pro Ala           
            310                 315                 320                   

aac aga tct tca gtc cac cct gcc cca ccc tta cat gaa tcc atg gcc       1186
Asn Arg Ser Ser Val His Pro Ala Pro Pro Leu His Glu Ser Met Ala           
        325                 330                 335                       

cta gag cac ttc taa gcagagatta tttgtgatcc catccattcc ccaataaagc       1241
Leu Glu His Phe                                                           
    340                                                                   

aaggcttgtc cgacaaa                                                    1258


<210>  2
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Gln Ala Ser Gly His Arg Arg Ser Thr Arg Gly Ser Lys Met 
1               5                   10                  15      


Val Ser Trp Ser Val Ile Ala Lys Ile Gln Glu Ile Leu Gln Arg Lys 
            20                  25                  30          


Met Val Arg Glu Phe Leu Ala Glu Phe Met Ser Thr Tyr Val Met Met 
        35                  40                  45              


Val Phe Gly Leu Gly Ser Val Ala His Met Val Leu Asn Lys Lys Tyr 
    50                  55                  60                  


Gly Ser Tyr Leu Gly Val Asn Leu Gly Phe Gly Phe Gly Val Thr Met 
65                  70                  75                  80  


Gly Val His Val Ala Gly Arg Ile Ser Gly Ala His Met Asn Ala Ala 
                85                  90                  95      


Val Thr Phe Ala Asn Cys Ala Leu Gly Arg Val Pro Trp Arg Lys Phe 
            100                 105                 110         


Pro Val Tyr Val Leu Gly Gln Phe Leu Gly Ser Phe Leu Ala Ala Ala 
        115                 120                 125             


Thr Ile Tyr Ser Leu Phe Tyr Thr Ala Ile Leu His Phe Ser Gly Gly 
    130                 135                 140                 


Gln Leu Met Val Thr Gly Pro Val Ala Thr Ala Gly Ile Phe Ala Thr 
145                 150                 155                 160 


Tyr Leu Pro Asp His Met Thr Leu Trp Arg Gly Phe Leu Asn Glu Ala 
                165                 170                 175     


Trp Leu Thr Gly Met Leu Gln Leu Cys Leu Phe Ala Ile Thr Asp Gln 
            180                 185                 190         


Glu Asn Asn Pro Ala Leu Pro Gly Thr Glu Ala Leu Val Ile Gly Ile 
        195                 200                 205             


Leu Val Val Ile Ile Gly Val Ser Leu Gly Met Asn Thr Gly Tyr Ala 
    210                 215                 220                 


Ile Asn Pro Ser Arg Asp Leu Pro Pro Arg Ile Phe Thr Phe Ile Ala 
225                 230                 235                 240 


Gly Trp Gly Lys Gln Val Phe Ser Asn Gly Glu Asn Trp Trp Trp Val 
                245                 250                 255     


Pro Val Val Ala Pro Leu Leu Gly Ala Tyr Leu Gly Gly Ile Ile Tyr 
            260                 265                 270         


Leu Val Phe Ile Gly Ser Thr Ile Pro Arg Glu Pro Leu Lys Leu Glu 
        275                 280                 285             


Asp Ser Val Ala Tyr Glu Asp His Gly Ile Thr Val Leu Pro Lys Met 
    290                 295                 300                 


Gly Ser His Glu Pro Thr Ile Ser Pro Leu Thr Pro Val Ser Val Ser 
305                 310                 315                 320 


Pro Ala Asn Arg Ser Ser Val His Pro Ala Pro Pro Leu His Glu Ser 
                325                 330                 335     


Met Ala Leu Glu His Phe 
            340         


<210>  3
<211>  1267
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  CDS
<222>  (262)..(1071)

<400>  3
gccaaacccc tgccctactg acctctcccc tagaggagca caaggggact cacagccgcc       60

ctgggcaaga ggcaggctct gagtgaggac ttagagactg cagagcctca gttcagttac      120

agcttgagcc tgccgcagta atggaggacc agaaacaaga ttatctgtga tactgacaga      180

ggggctgtga gacaaggcta aaaaacagag cagtcacttc agcagagtga gcagggctgc      240

aggtccaccc acaattccac a atg gcc ggt tct gtg ctg gag aac ata caa        291
                        Met Ala Gly Ser Val Leu Glu Asn Ile Gln           
                        1               5                   10            

tca gtg cta cag aag act tgg gtg cgt gag ttc ctg gcg gag ttc ctg        339
Ser Val Leu Gln Lys Thr Trp Val Arg Glu Phe Leu Ala Glu Phe Leu           
                15                  20                  25                

agt acc tat gtc ttg atg gtg ttt ggc ctt ggt tcc gtg gct cat atg        387
Ser Thr Tyr Val Leu Met Val Phe Gly Leu Gly Ser Val Ala His Met           
            30                  35                  40                    

gtt cta gga gaa agg ctt ggc agc tat ctt ggt gtc aac ttg ggt ttt        435
Val Leu Gly Glu Arg Leu Gly Ser Tyr Leu Gly Val Asn Leu Gly Phe           
        45                  50                  55                        

ggt ttc gga gtg acc atg gga ata cat gtg gca ggc ggc atc tct gga        483
Gly Phe Gly Val Thr Met Gly Ile His Val Ala Gly Gly Ile Ser Gly           
    60                  65                  70                            

gcc cac atg aac gcc gcg gtg act ttc act aac tgt gca cta ggc cga        531
Ala His Met Asn Ala Ala Val Thr Phe Thr Asn Cys Ala Leu Gly Arg           
75                  80                  85                  90            

atg gcc tgg aag aag ttc cct ata tat gtg ctg ggt cag ttc ctg ggt        579
Met Ala Trp Lys Lys Phe Pro Ile Tyr Val Leu Gly Gln Phe Leu Gly           
                95                  100                 105               

tcc ttc tta gct gca gct acc acc tac tta att ttc tat ggt gcc att        627
Ser Phe Leu Ala Ala Ala Thr Thr Tyr Leu Ile Phe Tyr Gly Ala Ile           
            110                 115                 120                   

aac cac tat gca ggt gga gaa ctg ttg gtg aca ggt ccc aaa tcc act        675
Asn His Tyr Ala Gly Gly Glu Leu Leu Val Thr Gly Pro Lys Ser Thr           
        125                 130                 135                       

gca aac att ttt gcc acc tat ctt cct gaa cac atg acg ctg tgg cgg        723
Ala Asn Ile Phe Ala Thr Tyr Leu Pro Glu His Met Thr Leu Trp Arg           
    140                 145                 150                           

ggc ttc gtg gat gag gta ttt gtg act ggg atg ctc cag ctg tgt atc        771
Gly Phe Val Asp Glu Val Phe Val Thr Gly Met Leu Gln Leu Cys Ile           
155                 160                 165                 170           

ttc gcc atc acg gac aag ttg aac agt cca gca ctt caa ggg acc gag        819
Phe Ala Ile Thr Asp Lys Leu Asn Ser Pro Ala Leu Gln Gly Thr Glu           
                175                 180                 185               

ccc ctc atg ata ggc atc ctt gtt tgc gtt ctt ggg gtg tcc cta ggc        867
Pro Leu Met Ile Gly Ile Leu Val Cys Val Leu Gly Val Ser Leu Gly           
            190                 195                 200                   

atg aac aca gga tat gca atc aac cca tcc cgt gac ctg cct ccc cgg        915
Met Asn Thr Gly Tyr Ala Ile Asn Pro Ser Arg Asp Leu Pro Pro Arg           
        205                 210                 215                       

ttc ttc act ttc att gct ggc tgg ggc aag aaa gtg ttc agt gcc ggg        963
Phe Phe Thr Phe Ile Ala Gly Trp Gly Lys Lys Val Phe Ser Ala Gly           
    220                 225                 230                           

aac aac tgg tgg tgg gtg ccg gtg gtg gca ccc ctt ctg ggt gcc tac       1011
Asn Asn Trp Trp Trp Val Pro Val Val Ala Pro Leu Leu Gly Ala Tyr           
235                 240                 245                 250           

tta ggt ggc att gta tac ctg ggc tta att cac gcc ggc ata cca cca       1059
Leu Gly Gly Ile Val Tyr Leu Gly Leu Ile His Ala Gly Ile Pro Pro           
                255                 260                 265               

cag ggt tct tag agattggaga attgtacaac aggagaccag aagacgacag           1111
Gln Gly Ser                                                               
                                                                          

catcgtccaa cgatcccctc accccatctc ttctcctcca acttctgcga aacctaccct     1171

acccataagt ggttctgtgc ctctagcttc tagagtactt cttagtagag cttgtctgtg     1231

accacaaccc ttctgcaata aagcacacct catacc                               1267


<210>  4
<211>  269
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Ala Gly Ser Val Leu Glu Asn Ile Gln Ser Val Leu Gln Lys Thr 
1               5                   10                  15      


Trp Val Arg Glu Phe Leu Ala Glu Phe Leu Ser Thr Tyr Val Leu Met 
            20                  25                  30          


Val Phe Gly Leu Gly Ser Val Ala His Met Val Leu Gly Glu Arg Leu 
        35                  40                  45              


Gly Ser Tyr Leu Gly Val Asn Leu Gly Phe Gly Phe Gly Val Thr Met 
    50                  55                  60                  


Gly Ile His Val Ala Gly Gly Ile Ser Gly Ala His Met Asn Ala Ala 
65                  70                  75                  80  


Val Thr Phe Thr Asn Cys Ala Leu Gly Arg Met Ala Trp Lys Lys Phe 
                85                  90                  95      


Pro Ile Tyr Val Leu Gly Gln Phe Leu Gly Ser Phe Leu Ala Ala Ala 
            100                 105                 110         


Thr Thr Tyr Leu Ile Phe Tyr Gly Ala Ile Asn His Tyr Ala Gly Gly 
        115                 120                 125             


Glu Leu Leu Val Thr Gly Pro Lys Ser Thr Ala Asn Ile Phe Ala Thr 
    130                 135                 140                 


Tyr Leu Pro Glu His Met Thr Leu Trp Arg Gly Phe Val Asp Glu Val 
145                 150                 155                 160 


Phe Val Thr Gly Met Leu Gln Leu Cys Ile Phe Ala Ile Thr Asp Lys 
                165                 170                 175     


Leu Asn Ser Pro Ala Leu Gln Gly Thr Glu Pro Leu Met Ile Gly Ile 
            180                 185                 190         


Leu Val Cys Val Leu Gly Val Ser Leu Gly Met Asn Thr Gly Tyr Ala 
        195                 200                 205             


Ile Asn Pro Ser Arg Asp Leu Pro Pro Arg Phe Phe Thr Phe Ile Ala 
    210                 215                 220                 


Gly Trp Gly Lys Lys Val Phe Ser Ala Gly Asn Asn Trp Trp Trp Val 
225                 230                 235                 240 


Pro Val Val Ala Pro Leu Leu Gly Ala Tyr Leu Gly Gly Ile Val Tyr 
                245                 250                 255     


Leu Gly Leu Ile His Ala Gly Ile Pro Pro Gln Gly Ser 
            260                 265                 


<210>  5
<211>  2524
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (441)..(1352)

<400>  5
aagaacagag atgctatttt gggcagtgtg tatggacttg gcttaagtgg catgggccaa       60

acccctgccc tactgacctc tcccctggag aagcacaaca gaactcacag ccaccctggg      120

gagggcccag aggcaggctc aagtgaggac tcggagaccg cagagctaca gttcagttgc      180

agcttgagtc tgcctccctg atagagaaac ggaatcaaga ccagctgtga gacggaggct      240

gaaagacaca gagcacttca gagaacctac ttcataagac cagcaactcg acgccgggtg      300

aaaattacca tctccgcact gcacctccag cctctctcgt cttcctgtgg gtctcagctc      360

agacaggggt ccccttctcc tcggctccag ccagaagtca aggcttggtc tgctgcttca      420

ggtccaccca caactccaca atg gcc ccc agg tct gtg ctg gag acc ata caa      473
                      Met Ala Pro Arg Ser Val Leu Glu Thr Ile Gln         
                      1               5                   10              

tca gtg cta cag aag aat atg gtg cga gag ttt ctg gca gag ttc ctg        521
Ser Val Leu Gln Lys Asn Met Val Arg Glu Phe Leu Ala Glu Phe Leu           
            15                  20                  25                    

agt acc tat gtc atg atg gtg ttt ggc ctt ggt tcc gtg gct cac atg        569
Ser Thr Tyr Val Met Met Val Phe Gly Leu Gly Ser Val Ala His Met           
        30                  35                  40                        

gtt tta gga gaa aac tct ggc agc tat ctc ggt gtc aac ttg ggt ttt        617
Val Leu Gly Glu Asn Ser Gly Ser Tyr Leu Gly Val Asn Leu Gly Phe           
    45                  50                  55                            

gga ttc gga gtg acc atg gga gtc cat gta gca ggc ggc atc tct ggg        665
Gly Phe Gly Val Thr Met Gly Val His Val Ala Gly Gly Ile Ser Gly           
60                  65                  70                  75            

gcc cac atg aat gcc gca gtg act ttc acc aat tgt gca cta ggc cga        713
Ala His Met Asn Ala Ala Val Thr Phe Thr Asn Cys Ala Leu Gly Arg           
                80                  85                  90                

atg acc tgg aag aag ttc cct gta tat gtg ctg ggt cag ttc ctg ggc        761
Met Thr Trp Lys Lys Phe Pro Val Tyr Val Leu Gly Gln Phe Leu Gly           
            95                  100                 105                   

tcc ttc tca gct gca gct acc acc tac tta att ttc tat ggt gcc att        809
Ser Phe Ser Ala Ala Ala Thr Thr Tyr Leu Ile Phe Tyr Gly Ala Ile           
        110                 115                 120                       

aac cac ttt gca ggc gga gac ctg ttg gtg aca ggt tcc aag gcc act        857
Asn His Phe Ala Gly Gly Asp Leu Leu Val Thr Gly Ser Lys Ala Thr           
    125                 130                 135                           

gca aac att ttt gcc acc tat ctt cct gaa tac atg aca ctg tgg cgg        905
Ala Asn Ile Phe Ala Thr Tyr Leu Pro Glu Tyr Met Thr Leu Trp Arg           
140                 145                 150                 155           

ggc ttc ctg gat gag gca ttc gtg act ggg atg ctg cag ctg tgt ctc        953
Gly Phe Leu Asp Glu Ala Phe Val Thr Gly Met Leu Gln Leu Cys Leu           
                160                 165                 170               

ttc gcc atc acc gac aag aag aac agt cca gca ctt caa ggg acc gag       1001
Phe Ala Ile Thr Asp Lys Lys Asn Ser Pro Ala Leu Gln Gly Thr Glu           
            175                 180                 185                   

ccc ctc gtg ata ggc atc ctt gtt acc gtc ctt ggg gtg tcg cta ggc       1049
Pro Leu Val Ile Gly Ile Leu Val Thr Val Leu Gly Val Ser Leu Gly           
        190                 195                 200                       

atg aac tcc gga tat gca atc aac cca tcc cgt gac ctg cct ccc cgg       1097
Met Asn Ser Gly Tyr Ala Ile Asn Pro Ser Arg Asp Leu Pro Pro Arg           
    205                 210                 215                           

ttg ttc act ttc att gct ggc tgg ggc aaa caa gtg ttc aga gcc gga       1145
Leu Phe Thr Phe Ile Ala Gly Trp Gly Lys Gln Val Phe Arg Ala Gly           
220                 225                 230                 235           

aac aac tgg tgg tgg gtg ccg gtg gtg gca cca ctt ctg ggc gcc tac       1193
Asn Asn Trp Trp Trp Val Pro Val Val Ala Pro Leu Leu Gly Ala Tyr           
                240                 245                 250               

cta ggt ggt att gta tac ctg ggt tta att cac ccc agc ata cca cag       1241
Leu Gly Gly Ile Val Tyr Leu Gly Leu Ile His Pro Ser Ile Pro Gln           
            255                 260                 265                   

gat cct cag aga ctg gag aat ttt aca gca aga gac cag aag gta act       1289
Asp Pro Gln Arg Leu Glu Asn Phe Thr Ala Arg Asp Gln Lys Val Thr           
        270                 275                 280                       

gca tca tac aag aat gca gct tct gca aac ata agt ggc tct gtg cct       1337
Ala Ser Tyr Lys Asn Ala Ala Ser Ala Asn Ile Ser Gly Ser Val Pro           
    285                 290                 295                           

cta gag cac ttc taa gtagagcttc tctttgacca caaccgtact gcaataaagc       1392
Leu Glu His Phe                                                           
300                                                                       

acaccaccta tcagcggtcc cccactcctt gggatctcct gcagctgaac tccctcctag     1452

gtttttctgg gagcttctga gttattccag cctggtactt gtcgtggaga gcaggctggc     1512

cttgaacttg tgatcttctt gcctctttct cctgagtgct ggggatacag gcatttacta     1572

ccctgcttgg catattccag ggtgattctg ggctcttttc tgaggactag agcatagggt     1632

cagaagactc cagctctttc cagttctagg aggtggggtg tcaaggggga atgtctactt     1692

tgggggctca gggtgagtga tataaagggc tttcgtgcat cagtatgtgt gttgggggaa     1752

cagtgagaaa aagaccggag gtagctgatg ggagatcaga tttgggggtc tttgacggtt     1812

ttctggatag gagtacagga tctcctggct tctcccttcc tctagttttg agccagagaa     1872

ggtaaggcta agagtttaca tcagaattcc tcaacttttt tttttttttt ttgttaatga     1932

cttcctcagt ggccttgtag ttctccaccc ctgtttttct taaaattatg tagcccaggc     1992

tagccttgac tggaactctt atataactaa gtttagccat gaactctgga ttgtctggcc     2052

tccacctcct gagttctggg attacaggtg cgcaccacca ttcccagttt atatgtggtg     2112

ctgggatcaa acccaaggcc ttgtgtatgc taggtaatat ccataactaa cttaaatccc     2172

agctccccag ttttttcttt tcttgtcttt tctctttctt tctctctttc tttctttctt     2232

tctttctttc tttctttctt tctttctttc tttctttctt tcttctttct ttccttcctt     2292

ccttccttcc ttccttcctt ccttccttcc tttctttttt tttttctttt tttggttttt     2352

caagacaggg tttctcggtg tagccctggc tgtcctggaa ctcactttgt agactaggct     2412

ggcctcgaac tcagaaatcc gcctgcctct gcctcccaag tgctgggatt aaaggcgtgc     2472

gccaccactg cccggcccaa attttttctt aattaaaaat tttaatacca ca             2524


<210>  6
<211>  303
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Pro Arg Ser Val Leu Glu Thr Ile Gln Ser Val Leu Gln Lys 
1               5                   10                  15      


Asn Met Val Arg Glu Phe Leu Ala Glu Phe Leu Ser Thr Tyr Val Met 
            20                  25                  30          


Met Val Phe Gly Leu Gly Ser Val Ala His Met Val Leu Gly Glu Asn 
        35                  40                  45              


Ser Gly Ser Tyr Leu Gly Val Asn Leu Gly Phe Gly Phe Gly Val Thr 
    50                  55                  60                  


Met Gly Val His Val Ala Gly Gly Ile Ser Gly Ala His Met Asn Ala 
65                  70                  75                  80  


Ala Val Thr Phe Thr Asn Cys Ala Leu Gly Arg Met Thr Trp Lys Lys 
                85                  90                  95      


Phe Pro Val Tyr Val Leu Gly Gln Phe Leu Gly Ser Phe Ser Ala Ala 
            100                 105                 110         


Ala Thr Thr Tyr Leu Ile Phe Tyr Gly Ala Ile Asn His Phe Ala Gly 
        115                 120                 125             


Gly Asp Leu Leu Val Thr Gly Ser Lys Ala Thr Ala Asn Ile Phe Ala 
    130                 135                 140                 


Thr Tyr Leu Pro Glu Tyr Met Thr Leu Trp Arg Gly Phe Leu Asp Glu 
145                 150                 155                 160 


Ala Phe Val Thr Gly Met Leu Gln Leu Cys Leu Phe Ala Ile Thr Asp 
                165                 170                 175     


Lys Lys Asn Ser Pro Ala Leu Gln Gly Thr Glu Pro Leu Val Ile Gly 
            180                 185                 190         


Ile Leu Val Thr Val Leu Gly Val Ser Leu Gly Met Asn Ser Gly Tyr 
        195                 200                 205             


Ala Ile Asn Pro Ser Arg Asp Leu Pro Pro Arg Leu Phe Thr Phe Ile 
    210                 215                 220                 


Ala Gly Trp Gly Lys Gln Val Phe Arg Ala Gly Asn Asn Trp Trp Trp 
225                 230                 235                 240 


Val Pro Val Val Ala Pro Leu Leu Gly Ala Tyr Leu Gly Gly Ile Val 
                245                 250                 255     


Tyr Leu Gly Leu Ile His Pro Ser Ile Pro Gln Asp Pro Gln Arg Leu 
            260                 265                 270         


Glu Asn Phe Thr Ala Arg Asp Gln Lys Val Thr Ala Ser Tyr Lys Asn 
        275                 280                 285             


Ala Ala Ser Ala Asn Ile Ser Gly Ser Val Pro Leu Glu His Phe 
    290                 295                 300             


<210>  7
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  7
cgcgagatct accatggccg gttctgtgct                                        30


<210>  8
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  8
ggcctctaga ctaagaaccc tgtggtggta tgc                                    33


<210>  9
<211>  19
<212>  DNA
<213>  Rattus norvegicus

<400>  9
cctgtccagc agaaagagc                                                    19


<210>  10
<211>  31
<212>  DNA
<213>  Rattus norvegicus

<400>  10
caggcaaagt caagcattca tatttattgt g                                      31


<210>  11
<211>  19
<212>  DNA
<213>  Rattus norvegicus

<400>  11
ggtgctgccc cagatgatt                                                    19


<210>  12
<211>  21
<212>  DNA
<213>  Rattus norvegicus

<400>  12
ctggagactg gctaggactt c                                                 21


<210>  13
<211>  17
<212>  DNA
<213>  Rattus norvegicus

<400>  13
ggccagatcg cgctaca                                                      17


<210>  14
<211>  22
<212>  DNA
<213>  Rattus norvegicus

<400>  14
gggccaatta gagagcaggt tt                                                22


<210>  15
<211>  24
<212>  DNA
<213>  Rattus norvegicus

<400>  15
ccacctacaa cagcatcatg aagt                                              24


<210>  16
<211>  22
<212>  DNA
<213>  Rattus norvegicus

<400>  16
gacatgacgt tgttggcgta ca                                                22


<210>  17
<211>  18
<212>  DNA
<213>  Rattus norvegicus

<400>  17
cgctcagtca tggcggat                                                     18


<210>  18
<211>  17
<212>  DNA
<213>  Rattus norvegicus

<400>  18
gccccaaatg cagccat                                                      17


<210>  19
<211>  18
<212>  DNA
<213>  Rattus norvegicus

<400>  19
gcgaaggtca agctgctt                                                     18


<210>  20
<211>  21
<212>  DNA
<213>  Rattus norvegicus

<400>  20
ctgggctcca atcctgtcaa t                                                 21


<210>  21
<211>  2450
<212>  DNA
<213>  Rattus norvegicus

<400>  21
gaaatactca agttaataaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaagagtacc       60

gactgctctt ccagaggtcc tgagttcaaa tcccagtaac cacatcacgg ttcacaacca      120

tttgtaatgg ggtctgatgc cctcttctgg tgtgtctgaa gacagctaca gtgtactcac      180

atacataaaa taaataaatg tctaaaaaaa aagaaaagaa aaaaaaaaag gaaaatgcct      240

tcactcactc agccttataa ccatcctttt ttttcccctt atatttcatt ttattttatg      300

tgtgtgggtg tttgtatggg tgttgggcct gagtgtgcct gaacactaca tgcagtgccc      360

aaaggagtca gaagaaggtg caggttaccc tggaactgga gttacagttg tttccttccc      420

ctgtgggtgc tgggattcga acatgggtcc tttggaaggg caacaagtac tctaaaacat      480

tgaaccacct tttcatcctc tgttttggtt gtttgagact tgccttgtta tatacagacc      540

tggctggctt agtacttgct acatagctca gctgggcttc aagtctttgt gttcctccta      600

cctcagtgct gggattaaag gtgacactat cataccaagt gaagacctgg gactggttcc      660

tagtgcgcgt gcgcgcgcac acacacacac acacacacac acacacacac acacacacgc      720

acttaactgt ataactgtat tcgatgtggt aaccctactc agagcctgcc ttaggggaaa      780

gggctctttc tgggtgtgtc ttctctgtgc ccagttatct gcactggtcc tatcgggact      840

agtgtgattc attattctga gtccctccct ccctccctcc ctccttcctg gtccctgtac      900

tgatcctcct ctgtccacgg tggaaccctc ctagcttcca acagagacca ccttccatcc      960

agtcagctct cccgggcaac cctctgcaaa cacgtgcctc actggcccct ccacaagcct     1020

ctgggcagcc cagggcctag gttcccatct ccctcccacc tattccttct tagtcctcct     1080

gtcccccaag gtcctggccc tcctctggag tttgctggaa gttcaaggcc tcagggatgt     1140

aggtcgtaaa gaagctctac tctgttcctt gcttagatcc ctttagaggc tgcttggccc     1200

ttgggatagt gaaaccaggt aaagcatttc atggtaaccc ctaacccaat ccgcaccctc     1260

tgttagaatg cgcatatata tatgtagctg tcttcagaca catcagaaga gggcatcaga     1320

tcccattaca gatggttgtg agccatcatg tagttactgg gaattgaact caggacctct     1380

ggaagagcag tcagtgctct taaccactga gccatctctc tagccctctg gaagactctt     1440

gcctctctag actggatata ttccaactct ctttctagtc taacagccaa cttctggttt     1500

catatgagag cctagcttta tttatttgac tcagagtttc tctgtgttgc tcaggctacc     1560

ctcaaactca gtacttctgc cccaggcctt ccaagtgcag ggaccatagg tgtgcacctc     1620

cacacctagt tccataactc tctccctctg ctgcctccct cctcccaaaa atgtttctct     1680

gtgtagcgct ggctgtccta gaacttgttc tgtagaccag gctggcccca aagtcagaga     1740

tctgcctgcc tctgcctccc gagtgctggg attaaaggag agcaccacca tcgtgtggcc     1800

catagctcac tattgaacgc atctcttgac tggacagcac tcatagggca gcgatgaagg     1860

caggcgttcc tctttcccag ggtgcagctc tccttttctg gaagaaatgc aatagtctga     1920

acccgcgtag gatctgctgt ggaatgaagc agacccttta gctgctcagg ctataatcag     1980

gagcggctga agcatcctgt tggcctaagg atgtggactg ttaagaaagt tcctgacatg     2040

gcccggtctt tggcgccctc tacaggaaag cttttcctct ttatactgtg ctcggctccc     2100

ttttattcct gcatagtcct ggttcagttt tacttcctaa agcgagtcca gcttctggaa     2160

cattaaaagg gaactgtttc aatgctcaat taaaacaaaa taaaaaaaat ggaacacttc     2220

ttaaatttat gtgtcatcct tgcgcaggga ccatactact actactacct tctctgtgct     2280

gttccagtgt caggatacgt ggggccaagg ggagtgagta ccgttttctc tctctctctc     2340

tctctctctc tctctctctc tctctctctc tctctctaaa atttatttag ttttttttcc     2400

aaggtaagtt tctttttttt ttttttttgg ttcttttttt cggagctggg                2450


