                         SEQUENCE LISTING

<110>  KHAKOO, AARIF
       CHAMPION, HUNTER
       CHINTALGATTU, VISHNU
       CALIN, GEORGE
 
<120>  MicroRNA SIGNATURE TO PREDICT PROGNOSIS IN HEART FAILURE

<130>  UTFC:1052WO

<140>  UNKNOWN
<141>  2010-03-31

<150>  61/167,028
<151>  2009-04-06

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  761
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Ser Gly Gly Gly Ser Leu Gly Leu His Thr Pro Asp Ser Arg 
1               5                   10                  15      


Met Ala His Thr Met Ile Met Gln Asp Phe Val Ala Gly Met Ala Gly 
            20                  25                  30          


Thr Ala His Ile Asp Gly Asp His Ile Val Val Ser Val Pro Glu Ala 
        35                  40                  45              


Val Leu Val Ser Asp Val Val Thr Asp Asp Gly Ile Thr Leu Asp His 
    50                  55                  60                  


Gly Leu Ala Ala Glu Val Val His Gly Pro Asp Ile Ile Thr Glu Thr 
65                  70                  75                  80  


Asp Val Val Thr Glu Gly Val Ile Val Pro Glu Ala Val Leu Glu Ala 
                85                  90                  95      


Asp Val Ala Ile Glu Glu Asp Leu Glu Glu Asp Asp Gly Asp His Ile 
            100                 105                 110         


Leu Thr Ser Glu Leu Ile Thr Glu Thr Val Arg Val Pro Glu Gln Val 
        115                 120                 125             


Phe Val Ala Asp Leu Val Thr Gly Pro Asn Gly His Leu Glu His Val 
    130                 135                 140                 


Val Gln Asp Cys Val Ser Gly Val Asp Ser Pro Thr Met Val Ser Glu 
145                 150                 155                 160 


Glu Val Leu Val Thr Asn Ser Asp Thr Glu Thr Val Ile Gln Ala Ala 
                165                 170                 175     


Gly Gly Val Pro Gly Ser Thr Val Thr Ile Lys Thr Glu Asp Asp Asp 
            180                 185                 190         


Asp Asp Asp Val Lys Ser Thr Ser Glu Asp Tyr Leu Met Ile Ser Leu 
        195                 200                 205             


Asp Asp Val Gly Glu Lys Leu Glu His Met Gly Asn Thr Pro Leu Lys 
    210                 215                 220                 


Ile Gly Ser Asp Gly Ser Gln Glu Asp Ala Lys Glu Asp Gly Phe Gly 
225                 230                 235                 240 


Ser Glu Val Ile Lys Val Tyr Ile Phe Lys Ala Glu Ala Glu Asp Asp 
                245                 250                 255     


Val Glu Ile Gly Gly Thr Glu Ile Val Thr Glu Ser Glu Tyr Thr Ser 
            260                 265                 270         


Gly His Ser Val Ala Gly Val Leu Asp Gln Ser Arg Met Gln Arg Glu 
        275                 280                 285             


Lys Met Val Tyr Met Ala Val Lys Asp Ser Ser Gln Glu Glu Asp Asp 
    290                 295                 300                 


Ile Arg Asp Glu Arg Arg Val Ser Arg Arg Tyr Glu Asp Cys Gln Ala 
305                 310                 315                 320 


Ser Gly Asn Thr Leu Asp Ser Ala Leu Glu Ser Arg Ser Ser Thr Ala 
                325                 330                 335     


Ala Gln Tyr Leu Gln Ile Cys Asp Gly Ile Asn Thr Asn Lys Val Leu 
            340                 345                 350         


Lys Gln Lys Ala Lys Lys Arg Arg Arg Gly Glu Thr Arg Gln Trp Gln 
        355                 360                 365             


Thr Ala Val Ile Ile Gly Pro Asp Gly Gln Pro Leu Thr Val Tyr Pro 
    370                 375                 380                 


Cys His Ile Cys Thr Lys Lys Phe Lys Ser Arg Gly Phe Leu Lys Arg 
385                 390                 395                 400 


His Met Lys Asn His Pro Asp His Leu Met Arg Lys Lys Tyr Gln Cys 
                405                 410                 415     


Thr Asp Cys Asp Phe Thr Thr Asn Lys Lys Val Ser Phe His Asn His 
            420                 425                 430         


Leu Glu Ser His Lys Leu Ile Asn Lys Val Asp Lys Thr His Glu Phe 
        435                 440                 445             


Thr Glu Tyr Thr Arg Arg Tyr Arg Glu Ala Ser Pro Leu Ser Ser Asn 
    450                 455                 460                 


Lys Leu Ile Leu Arg Asp Lys Glu Pro Lys Met His Lys Cys Lys Tyr 
465                 470                 475                 480 


Cys Asp Tyr Glu Thr Ala Glu Gln Gly Leu Leu Asn Arg His Leu Leu 
                485                 490                 495     


Ala Val His Ser Lys Asn Phe Pro His Val Cys Val Glu Cys Gly Lys 
            500                 505                 510         


Gly Phe Arg His Pro Ser Glu Leu Lys Lys His Met Arg Thr His Thr 
        515                 520                 525             


Gly Glu Lys Pro Tyr Gln Cys Gln Tyr Cys Ile Phe Arg Cys Ala Asp 
    530                 535                 540                 


Gln Ser Asn Leu Lys Thr His Ile Lys Ser Lys His Gly Asn Asn Leu 
545                 550                 555                 560 


Pro Tyr Lys Cys Glu His Cys Pro Gln Ala Phe Gly Asp Glu Arg Glu 
                565                 570                 575     


Leu Gln Arg His Leu Asp Leu Phe Gln Gly His Lys Thr His Gln Cys 
            580                 585                 590         


Pro His Cys Asp His Lys Ser Thr Asn Ser Ser Asp Leu Lys Arg His 
        595                 600                 605             


Ile Ile Ser Val His Thr Lys Asp Phe Pro His Lys Cys Glu Val Cys 
    610                 615                 620                 


Asp Lys Gly Phe His Arg Pro Ser Glu Leu Lys Lys His Ser Asp Ile 
625                 630                 635                 640 


His Lys Gly Arg Lys Ile His Gln Cys Arg His Cys Asp Phe Lys Thr 
                645                 650                 655     


Ser Asp Pro Phe Ile Leu Ser Gly His Ile Leu Ser Val His Thr Lys 
            660                 665                 670         


Asp Gln Pro Leu Lys Cys Lys Arg Cys Lys Arg Gly Phe Arg Gln Gln 
        675                 680                 685             


Asn Glu Leu Lys Lys His Met Lys Thr His Thr Gly Arg Lys Ile Tyr 
    690                 695                 700                 


Gln Cys Glu Tyr Cys Glu Tyr Ser Thr Thr Asp Ala Ser Gly Phe Lys 
705                 710                 715                 720 


Arg His Val Ile Ser Ile His Thr Lys Asp Tyr Pro His Arg Cys Glu 
                725                 730                 735     


Phe Cys Lys Lys Gly Phe Arg Arg Pro Ser Glu Lys Asn Gln His Ile 
            740                 745                 750         


Met Arg His His Lys Glu Ala Leu Met 
        755                 760     


<210>  2
<211>  2286
<212>  DNA
<213>  Homo sapiens

<400>  2
atggattcag gcggtggaag tcttggattg cacacgccag actctagaat ggcccatacc       60

atgattatgc aagattttgt ggctggaatg gctggtactg cacatatcga tggagaccat      120

attgttgttt cagttcctga agctgtttta gtttctgatg ttgtcacaga tgatgggata      180

actcttgatc atggccttgc agctgaagtt gtccatggac ctgatatcat cacagagact      240

gatgtagtaa cagaaggtgt gattgttcct gaagcggtac ttgaagctga tgttgccatt      300

gaagaggatt tagaggaaga tgatggtgat cacatcttga cttctgaact aattacagaa      360

accgttaggg taccagagca ggttttcgtg gctgaccttg ttactggtcc taatggacac      420

ttagaacatg tggtccaaga ttgtgtttca ggagtcgact ctcccacaat ggtatcagag      480

gaggttcttg taactaattc agatacagaa actgtgattc aagcagctgg aggtgttcct      540

ggttctacag ttactataaa aaccgaagat gatgatgatg atgatgtcaa gagcacttct      600

gaagactact taatgatatc tttggatgat gttggagaaa aattagagca tatggggaat      660

acaccattaa aaattggcag tgatggttca caagaagatg ctaaagaaga tgggtttggt      720

tctgaagtta taaaagtgta tatatttaaa gcggaggctg aagatgatgt tgaaataggt      780

ggaacagaaa ttgtcacaga gagtgagtac accagtggac attcagtagc tggagtgctt      840

gaccagagcc gaatgcagcg ggagaagatg gtttacatgg cagttaaaga ttcttctcaa      900

gaagaagatg atatcagaga tgaaagaaga gtttcccgaa ggtatgaaga ttgtcaagca      960

tcaggaaata ctttggactc agcattagaa agcagaagta gtacagcagc acagtacctt     1020

caaatttgtg acggcattaa tacaaataaa gtacttaaac aaaaagccaa aaagaggaga     1080

aggggagaaa ccaggcagtg gcaaacagct gttataatag gtcctgatgg acagcccctc     1140

acagtgtacc cttgccatat ttgcacaaaa aagtttaaat ccaggggatt cttaaaaaga     1200

cacatgaaga atcatcctga tcatttaatg agaaaaaaat atcagtgtac agattgtgac     1260

tttacaacta acaagaaagt gagtttccat aaccacttag aaagccataa gctcataaac     1320

aaagtcgaca aaacccatga atttacagaa tacacacgaa gatacagaga ggctagtcca     1380

ctgagttcca ataaacttat tttaagagac aaggagccga agatgcacaa gtgcaaatac     1440

tgtgactatg aaactgcaga acaaggactg ttaaacaggc atttgttggc cgttcacagc     1500

aagaattttc ctcatgtttg tgttgagtgt gggaagggtt ttcgacatcc ttctgaactc     1560

aagaaacata tgagaaccca tactggtgag aagccatatc agtgtcagta ttgtattttc     1620

aggtgtgcag atcaatcaaa tctgaaaact cacattaagt ctaaacatgg taacaatttg     1680

ccatataaat gtgagcattg tccccaagca tttggtgatg agagggagct tcaacgccat     1740

ctggatttgt ttcaaggaca taagacacac cagtgtcctc attgtgacca taagagcacc     1800

aattcaagtg accttaagcg gcacatcata tctgtccata ctaaggattt tcctcacaaa     1860

tgtgaggtct gtgataaagg ttttcatcgt ccttctgagc tcaaaaagca tagtgatatc     1920

cataagggta ggaagattca tcagtgcagg cactgtgact ttaaaacatc cgatccattt     1980

attcttagtg gccatatcct ttcagttcat actaaagatc agccattgaa atgtaaaagg     2040

tgcaagagag gattcagaca acaaaatgag ctaaaaaaac atatgaagac ccatactgga     2100

aggaagattt accaatgtga gtattgtgaa tacagcacta cagatgcatc tggctttaaa     2160

cgacatgtga tatcaataca tacaaaagac tatccacaca ggtgtgaatt ctgcaagaag     2220

ggattccgaa gaccatcaga aaaaaatcag catattatga ggcaccacaa agaggctctt     2280

atgtaa                                                                2286


<210>  3
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  3
acuguugcua auaugcaacu cu                                                22


<210>  4
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  4
uacccuguag auccgaauuu gug                                               23


<210>  5
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  5
ucgugucuug uguugcagcc gg                                                22


<210>  6
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  6
aacuguuugc agaggaaacu ga                                                22


<210>  7
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  7
uugugcuuga ucuaaccaug u                                                 21


<210>  8
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  8
uacccuguag aaccgaauuu gug                                               23


<210>  9
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  9
ugccugucua cacuugcugu gc                                                22


<210>  10
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  10
ugggucuuug cgggcgagau ga                                                22


<210>  11
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  11
ggcuggcucg cgaugucugu uu                                                22


