                         SEQUENCE LISTING

<110>  Institut National de la Recherche Agronomique (INRA)
       Universit de Limoges
 
<120>  Caspasin inhibitor peptides

<130>  BET 10P0184

<150>  EP 09305300.7
<151>  2009-04-08

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  411
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(411)
<223>  bovine SERPINA3-1

<220>
<221>  SITE
<222>  (374)..(374)
<223>  trypsin cleavage site

<220>
<221>  SITE
<222>  (395)..(395)
<223>  caspase cleavage site

<400>  1

Met Arg Ala Glu Arg Thr Ser Phe Leu Leu Ala Leu Gly Leu Leu Val 
1               5                   10                  15      


Ala Gly Ile Arg Ser Val His Cys Leu Pro Glu Asn Val Val Val Lys 
            20                  25                  30          


Asp Gln His Arg Arg Val Asp Gly His Thr Leu Ala Ser Ser Asn Thr 
        35                  40                  45              


Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu Ala Leu Lys Asn Pro Asn 
    50                  55                  60                  


Lys Asn Val Ile Leu Ser Pro Leu Ser Val Ser Ile Ala Leu Ala Phe 
65                  70                  75                  80  


Leu Ser Leu Gly Ala Arg Gly Ser Thr Leu Thr Glu Ile Leu Glu Gly 
                85                  90                  95      


Leu Lys Phe Asn Leu Thr Glu Ile Gln Glu Lys Glu Ile His His Ser 
            100                 105                 110         


Phe Gln His Leu Leu Gln Ala Leu Asn Gln Pro Ser Asn Gln Leu Gln 
        115                 120                 125             


Leu Ser Val Gly Asn Ala Met Phe Val Gln Glu Glu Leu Lys Leu Leu 
    130                 135                 140                 


Asp Lys Phe Ile Glu Asp Ala Gln Val Leu Tyr Ser Ser Glu Ala Phe 
145                 150                 155                 160 


Pro Thr Asn Phe Arg Asp Ser Glu Ala Ala Arg Ser Leu Ile Asn Asp 
                165                 170                 175     


Tyr Val Lys Asn Lys Thr Gln Gly Lys Ile Glu Glu Leu Phe Lys Tyr 
            180                 185                 190         


Leu Ser Pro Arg Thr Glu Leu Val Leu Val Asn Tyr Ile Tyr Phe Lys 
        195                 200                 205             


Ala Gln Trp Lys Thr Pro Phe Asp Pro Lys His Thr Glu Gln Ala Glu 
    210                 215                 220                 


Phe His Val Ser Asp Asn Lys Thr Val Glu Val Pro Met Met Thr Leu 
225                 230                 235                 240 


Asp Leu Glu Thr Pro Tyr Phe Arg Asp Glu Glu Leu Gly Cys Thr Leu 
                245                 250                 255     


Val Glu Leu Thr Tyr Thr Ser Asn Asp Ser Ala Leu Phe Ile Leu Pro 
            260                 265                 270         


Asp Glu Gly Lys Met Arg Asp Leu Glu Ala Lys Leu Thr Pro Glu Thr 
        275                 280                 285             


Leu Thr Arg Trp Arg Asn Ser Leu Gln Pro Arg Arg Ile His Glu Leu 
    290                 295                 300                 


Tyr Leu Pro Lys Phe Ser Ile Lys Ser Asn Tyr Glu Leu Asn Asp Ile 
305                 310                 315                 320 


Leu Ser Gln Leu Gly Ile Arg Lys Ile Phe Ala Asn Ala Asp Leu Ser 
                325                 330                 335     


Gly Ile Thr Gly Thr Ala Asp Leu Val Val Ser Gln Val Val His Gly 
            340                 345                 350         


Ala Ala Leu Asp Val Asp Glu Glu Gly Thr Glu Gly Ala Ala Ala Thr 
        355                 360                 365             


Gly Ile Ser Met Glu Arg Thr Ile Leu Arg Ile Ile Val Arg Val Asn 
    370                 375                 380                 


Arg Pro Phe Leu Ile Ala Ile Val Leu Lys Asp Thr Gln Ser Ile Ile 
385                 390                 395                 400 


Phe Leu Gly Lys Val Thr Asn Pro Ser Glu Ala 
                405                 410     


<210>  2
<211>  411
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(411)
<223>  bovine SERPINA3-2

<220>
<221>  SITE
<222>  (374)..(374)
<223>  trypsin cleavage site

<220>
<221>  SITE
<222>  (395)..(395)
<223>  caspase cleavage site

<400>  2

Met Arg Ala Glu Arg Thr Ser Phe Leu Leu Ala Leu Gly Leu Leu Val 
1               5                   10                  15      


Ala Gly Ile Arg Ser Val His Cys Leu Pro Glu Asn Val Val Val Lys 
            20                  25                  30          


Asp Gln His Arg Arg Val Asp Gly His Thr Leu Ala Ser Ser Asn Thr 
        35                  40                  45              


Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu Ala Leu Lys Asn Pro Asn 
    50                  55                  60                  


Lys Asn Val Ile Leu Ser Pro Leu Ser Val Ser Ile Ala Leu Ala Phe 
65                  70                  75                  80  


Leu Ser Leu Gly Ala Arg Gly Ser Thr Leu Thr Glu Ile Leu Glu Gly 
                85                  90                  95      


Leu Lys Phe Asn Leu Thr Glu Ile Gln Glu Lys Glu Ile His His Ser 
            100                 105                 110         


Phe Gln His Leu Leu Gln Ala Leu Asn Gln Pro Ser Asn Gln Leu Gln 
        115                 120                 125             


Leu Ser Val Gly Asn Ala Met Phe Val Gln Glu Glu Leu Lys Leu Leu 
    130                 135                 140                 


Asp Lys Phe Ile Glu Asp Ala Gln Val Leu Tyr Ser Ser Glu Ala Phe 
145                 150                 155                 160 


Pro Thr Asn Phe Arg Asp Ser Glu Ala Ala Arg Ser Leu Ile Asn Asp 
                165                 170                 175     


Tyr Val Lys Asn Lys Thr Gln Gly Lys Ile Glu Glu Leu Phe Lys Tyr 
            180                 185                 190         


Leu Ser Pro Arg Thr Glu Leu Val Leu Val Asn Tyr Ile Tyr Phe Lys 
        195                 200                 205             


Ala Gln Trp Lys Thr Pro Phe Asp Pro Lys His Thr Glu Gln Ala Glu 
    210                 215                 220                 


Phe His Val Ser Asp Asn Lys Thr Val Glu Val Pro Met Met Thr Leu 
225                 230                 235                 240 


Asp Leu Glu Thr Pro Tyr Phe Arg Asp Glu Glu Leu Gly Cys Thr Leu 
                245                 250                 255     


Val Glu Leu Thr Tyr Thr Ser Asn Asp Ser Ala Leu Phe Ile Leu Pro 
            260                 265                 270         


Asp Glu Gly Lys Met Arg Asp Leu Glu Ala Lys Leu Thr Pro Glu Thr 
        275                 280                 285             


Leu Thr Arg Trp Arg Asn Ser Leu Gln Pro Arg Arg Ile His Glu Leu 
    290                 295                 300                 


Tyr Leu Pro Lys Phe Ser Ile Lys Ser Asn Tyr Glu Leu Asn Asp Ile 
305                 310                 315                 320 


Leu Ser Gln Leu Gly Ile Arg Lys Ile Phe Ala Asn Ala Asp Leu Ser 
                325                 330                 335     


Gly Ile Thr Gly Thr Ala Asp Leu Val Val Ser Gln Val Val His Gly 
            340                 345                 350         


Ala Ala Leu Asp Val Asp Glu Glu Gly Thr Glu Gly Val Ala Ala Thr 
        355                 360                 365             


Gly Ile Gly Ile Glu Arg Thr Phe Leu Arg Ile Ile Val Arg Val Asn 
    370                 375                 380                 


Arg Pro Phe Leu Ile Ala Val Val Leu Lys Asp Thr Gln Ser Ile Ile 
385                 390                 395                 400 


Phe Leu Gly Lys Val Thr Asn Pro Ser Glu Ala 
                405                 410     


<210>  3
<211>  411
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(411)
<223>  bovine SERPINA3-3

<220>
<221>  SITE
<222>  (374)..(374)
<223>  trypsin cleavage site

<220>
<221>  SITE
<222>  (395)..(395)
<223>  caspase cleavage site

<400>  3

Met Arg Ala Glu Arg Leu Ser Pro Leu Leu Ala Leu Gly Leu Leu Val 
1               5                   10                  15      


Ala Gly Ile Arg Ser Val His Cys Leu Pro Glu Asn Val Val Val Lys 
            20                  25                  30          


Asp Arg His Arg Arg Val Asp Gly His Thr Leu Ala Ser Ser Asn Thr 
        35                  40                  45              


Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu Ala Leu Lys Asn Pro Asn 
    50                  55                  60                  


Lys Asn Val Met Phe Ser Pro Leu Ser Val Ser Met Ala Leu Ala Phe 
65                  70                  75                  80  


Leu Ser Leu Gly Ala Arg Gly Pro Thr Leu Thr Glu Ile Leu Glu Gly 
                85                  90                  95      


Leu Lys Phe Asn Leu Thr Glu Ile Gln Glu Thr Gln Ile His Gln Gly 
            100                 105                 110         


Phe Gln His Leu Leu Gln Ala Leu Asn Arg Pro Arg Asn Gln Leu Gln 
        115                 120                 125             


Leu Ser Val Gly Asn Ala Met Phe Val Gln Glu Glu Leu Lys Leu Leu 
    130                 135                 140                 


Asp Lys Phe Ile Glu Asp Ala Arg Val Leu Tyr Ser Ser Glu Ala Phe 
145                 150                 155                 160 


Pro Thr Asn Phe Arg Asp Pro Glu Ala Ala Lys Ser Leu Ile Asn Asp 
                165                 170                 175     


Tyr Val Lys Asn Lys Thr Gln Gly Lys Ile Glu Glu Leu Phe Lys Asp 
            180                 185                 190         


Leu Ser Pro Arg Thr Glu Leu Val Leu Val Asn Tyr Val Tyr Phe Lys 
        195                 200                 205             


Ala Gln Trp Lys Thr Arg Phe Asp Pro Lys His Thr Glu Gln Ala Glu 
    210                 215                 220                 


Phe His Val Ser Asp Asn Lys Thr Val Glu Val Pro Met Met Thr Leu 
225                 230                 235                 240 


Asp Leu Glu Thr Pro Tyr Phe Arg Asp Glu Glu Leu Gly Cys Thr Leu 
                245                 250                 255     


Val Glu Leu Thr Tyr Thr Ser Asn Asp Ser Ala Leu Phe Ile Leu Pro 
            260                 265                 270         


Asp Lys Gly Lys Met Gln Asp Leu Glu Ala Lys Leu Thr Pro Glu Met 
        275                 280                 285             


Leu Thr Arg Trp Arg Asn Ser Leu Gln Pro Arg Arg Ile His Glu Leu 
    290                 295                 300                 


Tyr Leu Pro Lys Phe Ser Ile Lys Ser Asn Tyr Glu Leu Asn Asp Thr 
305                 310                 315                 320 


Leu Ser Gln Met Gly Ile Lys Lys Ile Phe Thr Asp Ala Asp Leu Ser 
                325                 330                 335     


Gly Ile Thr Gly Thr Ala Asp Leu Val Val Ser Gln Val Val His Gly 
            340                 345                 350         


Ala Ala Leu Asp Val Asp Glu Glu Gly Thr Glu Gly Ala Ala Ala Thr 
        355                 360                 365             


Gly Ile Gly Ile Glu Arg Thr Phe Leu Arg Ile Ile Val Arg Val Asn 
    370                 375                 380                 


Arg Pro Phe Leu Ile Ala Val Val Leu Lys Asp Thr Gln Ser Ile Ile 
385                 390                 395                 400 


Phe Leu Gly Lys Val Thr Asn Pro Ser Glu Ala 
                405                 410     


<210>  4
<211>  411
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(411)
<223>  bovine SERPINA3-4

<220>
<221>  SITE
<222>  (374)..(374)
<223>  trypsin cleavage site

<220>
<221>  SITE
<222>  (395)..(395)
<223>  caspase cleavage site

<400>  4

Met Arg Ala Glu Arg Leu Ser Pro Leu Leu Ala Leu Gly Leu Leu Val 
1               5                   10                  15      


Ala Gly Ile Arg Ser Val His Cys Leu Pro Glu Asn Val Val Val Lys 
            20                  25                  30          


Asp Arg His Arg Arg Val Asp Gly His Thr Leu Ala Ser Ser Asn Thr 
        35                  40                  45              


Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu Ala Leu Lys Asp Pro Asn 
    50                  55                  60                  


Lys Asn Val Met Phe Ser Pro Leu Ser Val Ser Met Ala Leu Ala Phe 
65                  70                  75                  80  


Leu Ser Leu Gly Ala Arg Gly Pro Thr Leu Thr Glu Ile Leu Glu Gly 
                85                  90                  95      


Leu Lys Phe Asn Pro Thr Glu Ile Gln Glu Thr Gln Ile His Gln Gly 
            100                 105                 110         


Phe Gln His Leu Leu Gln Ala Leu Asn Arg Pro Arg Asn Gln Leu Gln 
        115                 120                 125             


Leu Ser Val Gly Asn Ala Met Phe Val Gln Glu Glu Leu Lys Leu Leu 
    130                 135                 140                 


Asp Lys Phe Ile Glu Asp Ala Arg Val Leu Tyr Ser Ser Glu Ala Phe 
145                 150                 155                 160 


Pro Thr Asn Phe Arg Asp Pro Glu Ala Ala Lys Ser Leu Ile Asn Asp 
                165                 170                 175     


Tyr Val Lys Asn Lys Thr Gln Gly Lys Ile Glu Glu Leu Phe Lys Asp 
            180                 185                 190         


Leu Ser Pro Arg Thr Glu Leu Val Leu Val Asn Tyr Val Tyr Phe Lys 
        195                 200                 205             


Ala Gln Trp Lys Thr Arg Phe Asp Pro Lys His Thr Glu Gln Ala Glu 
    210                 215                 220                 


Phe His Val Ser Asp Asn Lys Thr Val Glu Val Pro Met Met Thr Leu 
225                 230                 235                 240 


Asp Leu Glu Thr Pro Tyr Phe Arg Asp Glu Glu Leu Gly Cys Thr Leu 
                245                 250                 255     


Val Glu Leu Thr Tyr Thr Ser Asn Asp Ser Ala Leu Phe Ile Leu Pro 
            260                 265                 270         


Asp Lys Gly Lys Met Gln Asp Leu Glu Ala Lys Leu Thr Pro Glu Met 
        275                 280                 285             


Leu Thr Arg Trp Arg Asn Ser Leu Gln Pro Arg Arg Ile His Glu Leu 
    290                 295                 300                 


Tyr Leu Pro Lys Phe Ser Ile Lys Ser Asn Tyr Glu Leu Asn Asp Thr 
305                 310                 315                 320 


Leu Ser Gln Met Gly Ile Lys Lys Ile Phe Thr Asp Ala Asp Leu Ser 
                325                 330                 335     


Gly Ile Thr Gly Thr Ala Asp Leu Val Val Ser Gln Val Val His Gly 
            340                 345                 350         


Ala Ala Leu Asp Val Asp Glu Glu Gly Thr Glu Gly Ala Ala Ala Thr 
        355                 360                 365             


Gly Ile Gly Ile Glu Arg Thr Phe Leu Arg Ile Ile Val Arg Val Asn 
    370                 375                 380                 


Arg Pro Phe Leu Ile Ala Val Val Leu Lys Asp Thr Gln Ser Ile Ile 
385                 390                 395                 400 


Phe Leu Gly Lys Val Thr Asn Pro Ser Glu Ala 
                405                 410     


<210>  5
<211>  411
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(411)
<223>  bovine SERPINA3-5

<220>
<221>  SITE
<222>  (374)..(374)
<223>  trypsin cleavage site

<220>
<221>  SITE
<222>  (395)..(395)
<223>  caspase cleavage site

<400>  5

Met Arg Ala Glu Arg Thr Ser Phe Leu Leu Ala Leu Gly Leu Leu Met 
1               5                   10                  15      


Ala Gly Ile Arg Ser Val His Cys Leu Pro Glu Asn Val Val Val Lys 
            20                  25                  30          


Asp Gln Arg Arg Arg Val Asp Ser His Thr Leu Ala Ser Ser Asn Thr 
        35                  40                  45              


Asp Phe Ala Phe Ser Leu Thr Lys Gln Leu Ala Leu Lys Asn Pro Asn 
    50                  55                  60                  


Lys Asn Val Met Phe Ser Pro Leu Ser Val Ser Met Ala Leu Ala Phe 
65                  70                  75                  80  


Leu Ser Leu Gly Ala Arg Gly Pro Thr Leu Thr Glu Ile Leu Glu Gly 
                85                  90                  95      


Leu Lys Phe Asn Leu Thr Glu Ile Gln Glu Thr Gln Ile His Gln Gly 
            100                 105                 110         


Phe Gln His Leu Leu Gln Ala Leu Asn Arg Pro Ser Asn Gln Leu Gln 
        115                 120                 125             


Leu Ser Val Gly Asn Ala Met Phe Val Gln Glu Glu Leu Lys Leu Leu 
    130                 135                 140                 


Asp Lys Phe Ile Glu Asp Ala Arg Val Leu Tyr Ser Ser Glu Ala Phe 
145                 150                 155                 160 


Pro Thr Asn Phe Arg Asp Ser Glu Ala Ala Arg Ser Leu Ile Asn Asp 
                165                 170                 175     


Tyr Val Lys Asn Lys Thr Gln Gly Lys Ile Glu Glu Leu Phe Lys Tyr 
            180                 185                 190         


Leu Ser Pro Arg Thr Val Leu Val Leu Val Asn Tyr Ile Tyr Phe Lys 
        195                 200                 205             


Ala Gln Trp Lys Thr Arg Phe Asp Pro Lys His Thr Glu Gln Ala Glu 
    210                 215                 220                 


Phe His Val Ser Lys Asn Lys Thr Val Glu Val Thr Met Met Thr Leu 
225                 230                 235                 240 


Asp Leu Glu Thr Pro Tyr Phe Arg Asp Lys Glu Leu Gly Cys Met Leu 
                245                 250                 255     


Val Glu Leu Thr Tyr Ser Ser Asn Asp Ser Ala Leu Phe Ile Leu Pro 
            260                 265                 270         


Asp Glu Gly Lys Met Gln Asp Leu Glu Ala Lys Leu Thr Pro Glu Thr 
        275                 280                 285             


Leu Thr Arg Trp Arg Asn Ser Leu Gln Pro Arg Arg Ile His Glu Leu 
    290                 295                 300                 


Tyr Leu Pro Lys Phe Ser Ile Lys Ser Asn Tyr Glu Leu Asn Asp Thr 
305                 310                 315                 320 


Leu Ser Gln Met Gly Ile Lys Lys Ile Phe Thr Asp Ala Asp Leu Ser 
                325                 330                 335     


Gly Ile Thr Gly Thr Ala Asp Leu Val Val Ser Gln Val Val His Gly 
            340                 345                 350         


Ala Ala Leu Asp Val Asp Glu Glu Gly Thr Glu Gly Ala Ala Ala Thr 
        355                 360                 365             


Gly Ile Gly Ile Glu Arg Thr Phe Leu Arg Ile Ile Val Arg Val Asn 
    370                 375                 380                 


Arg Pro Phe Leu Ile Ala Val Val Leu Lys Asp Thr Gln Ser Ile Ile 
385                 390                 395                 400 


Phe Leu Gly Lys Val Thr Asn Pro Ser Glu Ala 
                405                 410     


<210>  6
<211>  414
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(414)
<223>  bovine SERPINA3-6

<220>
<221>  SITE
<222>  (377)..(377)
<223>  trypsin cleavage site

<220>
<221>  SITE
<222>  (398)..(398)
<223>  caspase cleavage site

<400>  6

Met Arg Thr Glu Arg Val Ser Pro Leu Leu Ala Leu Gly Ile Leu Val 
1               5                   10                  15      


Ala Gly Leu Cys Ser Arg Val His Cys Leu Pro Glu Asn Val Thr Pro 
            20                  25                  30          


Glu Glu Gln His Lys Val Thr Ser Val Asp Gly His Ser Leu Ala Ser 
        35                  40                  45              


Ser Asn Thr Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu Ala Leu Lys 
    50                  55                  60                  


Asp Pro Asn Lys Asn Val Ile Phe Ser Pro Leu Ser Val Ser Ile Ala 
65                  70                  75                  80  


Leu Ala Phe Leu Ser Leu Gly Ala His Gly Pro Thr Val Thr Glu Ile 
                85                  90                  95      


Leu Glu Gly Leu Lys Phe Asn Leu Thr Glu Thr Pro Glu Thr Glu Ile 
            100                 105                 110         


His Gln Gly Phe Gln His Leu Leu Gln Thr Phe Asn Gln Pro Ser Asn 
        115                 120                 125             


Gln Leu Gln Leu Ser Val Gly Asn Ala Ile Phe Val Gln Glu Glu Leu 
    130                 135                 140                 


Lys Leu Leu Asp Lys Phe Ile Glu Asp Ala Arg Val Leu Tyr Ser Ser 
145                 150                 155                 160 


Glu Ala Phe Pro Thr Asn Phe Arg Asp Pro Glu Ala Ala Lys Ser Leu 
                165                 170                 175     


Ile Asn Asp Tyr Val Lys Asn Lys Thr Gln Gly Lys Ile Glu Glu Leu 
            180                 185                 190         


Phe Lys Asp Leu Ser Pro Arg Thr Glu Leu Val Leu Val Asn Tyr Val 
        195                 200                 205             


Tyr Phe Lys Ala Gln Trp Lys Thr Arg Phe Asp Pro Lys His Thr Glu 
    210                 215                 220                 


Lys Thr Glu Phe His Val Ser Asp Asn Lys Thr Val Glu Val Pro Met 
225                 230                 235                 240 


Met Thr Leu Asp Leu Glu Thr Pro Tyr Phe Arg Asp Glu Glu Leu Gly 
                245                 250                 255     


Cys Thr Leu Val Glu Leu Thr Tyr Thr Ser Asn Asp Ser Ala Leu Phe 
            260                 265                 270         


Ile Leu Pro Asp Lys Gly Lys Met Gln Asp Leu Glu Ala Lys Leu Thr 
        275                 280                 285             


Pro Glu Met Leu Thr Arg Trp Arg Asn Ser Leu Gln Pro Arg Arg Ile 
    290                 295                 300                 


His Glu Leu Tyr Leu Pro Lys Phe Ser Ile Lys Ser Asn Tyr Glu Leu 
305                 310                 315                 320 


Asn Asp Thr Leu Ser Gln Met Gly Ile Lys Lys Ile Phe Thr Ala Asp 
                325                 330                 335     


Ala Leu Ser Gly Ile Thr Gly Thr Ala Asp Leu Val Val Ser Gln Val 
            340                 345                 350         


Val His Gly Ala Ala Leu Asp Val Asp Glu Glu Gly Thr Glu Gly Ala 
        355                 360                 365             


Ala Ala Thr Gly Ile Gly Ile Glu Arg Thr Phe Leu Arg Ile Ile Val 
    370                 375                 380                 


Arg Val Asn Arg Pro Phe Leu Ile Ala Val Val Leu Lys Asp Thr Gln 
385                 390                 395                 400 


Ser Ile Ile Phe Leu Gly Lys Val Thr Asn Pro Ser Glu Ala 
                405                 410                 


<210>  7
<211>  417
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(417)
<223>  bovine SERPINA3-7

<220>
<221>  SITE
<222>  (378)..(378)
<223>  trypsin cleavage site

<220>
<221>  SITE
<222>  (401)..(401)
<223>  caspase cleavage site

<400>  7

Met Arg Thr Glu Arg Thr Ser Phe Leu Leu Ala Leu Gly Leu Leu Val 
1               5                   10                  15      


Ser Gly Phe Cys Ser Arg Val His Cys Leu Pro Glu Asn Val Thr Pro 
            20                  25                  30          


Glu Glu Gln His Lys Gly Thr Ser Val Asp Gly His Ser Leu Ala Ser 
        35                  40                  45              


Ser Asn Thr Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu Ala Leu Lys 
    50                  55                  60                  


Asp Pro Asn Lys Asn Val Ile Phe Ser Pro Leu Ser Ile Ser Ile Ala 
65                  70                  75                  80  


Leu Ala Phe Leu Ser Leu Gly Ala His Asp His Thr Val Thr Glu Ile 
                85                  90                  95      


Leu Glu Gly Leu Lys Phe Asn Leu Thr Glu Thr Pro Glu Thr Glu Ile 
            100                 105                 110         


His Gln Gly Phe Gln His Leu Leu Gln Thr Phe Asn Gln Pro Ser Asn 
        115                 120                 125             


Gln Leu Gln Leu Ser Val Gly Asn Ala Met Phe Val Ser Glu Glu Leu 
    130                 135                 140                 


Lys Leu Leu Asp Lys Phe Arg Lys Asp Ala Glu Ala Phe Tyr Ala Ser 
145                 150                 155                 160 


Glu Val Leu Ser Thr Asn Phe Lys Asp Ser Glu Ala Ala Val Lys Leu 
                165                 170                 175     


Ile Asn Glu Tyr Val Lys Asn Lys Thr His Gly Lys Ile Glu Lys Leu 
            180                 185                 190         


Phe Asn Asp Leu Asp Val Leu Thr Asn Leu Ile Leu Val Asn Tyr Ile 
        195                 200                 205             


Phe Phe Lys Ala Gln Trp Lys Thr Pro Phe Asn Pro Asn His Thr Tyr 
    210                 215                 220                 


Glu Ser Glu Phe His Val Ser Gln Asn Glu Arg Val Ile Val Pro Met 
225                 230                 235                 240 


Met Thr Leu Tyr Leu Glu Thr Pro Tyr Phe Arg Asp Glu Glu Leu Gly 
                245                 250                 255     


Cys Thr Leu Val Glu Leu Thr Tyr Thr Ser Asn Asp Ser Ala Leu Phe 
            260                 265                 270         


Ile Leu Pro Asp Glu Gly Lys Met Gln Asp Leu Glu Ala Lys Leu Thr 
        275                 280                 285             


Pro Glu Thr Leu Thr Arg Trp Arg Asn Ser Leu Gln Pro Arg Leu Ile 
    290                 295                 300                 


His Arg Leu Arg Leu Pro Arg Phe Ser Ile Ser Ser His Tyr Gln Leu 
305                 310                 315                 320 


Lys Asp Ile Leu Ser Gln Leu Gly Ile Lys Lys Ile Phe Thr Ser Asp 
                325                 330                 335     


Ala Asp Phe Ser Gly Ile Thr Asp Asp His Lys Leu Ala Val Ser His 
            340                 345                 350         


Val Ile His Lys Ala Val Leu Asp Val Gly Glu Glu Gly Thr Glu Gly 
        355                 360                 365             


Ala Ala Val Thr Ala Val Val Met Ala Thr Ser Ser Leu Leu His Thr 
    370                 375                 380                 


Leu Thr Val Ser Phe Asn Arg Pro Phe Leu Leu Ser Ile Phe Cys Lys 
385                 390                 395                 400 


Glu Thr Gln Ser Ile Ile Phe Leu Gly Lys Val Thr Asn Pro Lys Glu 
                405                 410                 415     


Ala 
    


<210>  8
<211>  418
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(418)
<223>  bovine SERPINA3-8

<220>
<221>  SITE
<222>  (380)..(380)
<223>  trypsin cleavage site

<220>
<221>  SITE
<222>  (402)..(402)
<223>  caspase cleavage site

<400>  8

Met Arg Ala Glu Arg Met Ser Pro Leu Leu Ala Leu Gly Leu Leu Val 
1               5                   10                  15      


Ser Gly Leu Cys Ser Arg Val His Cys Leu Pro Glu Asn Val Ala Pro 
            20                  25                  30          


Glu Glu Arg His Lys Gly Thr Ser Val Asp Gly His Ser Leu Ala Ser 
        35                  40                  45              


Ser Asn Thr Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu Ala Leu Lys 
    50                  55                  60                  


Asn Pro Asn Lys Asn Val Ile Phe Ser Pro Leu Ser Ile Ser Ile Ala 
65                  70                  75                  80  


Leu Ala Phe Leu Ser Leu Gly Ala Arg Gly Pro Thr Val Thr Glu Ile 
                85                  90                  95      


Leu Glu Gly Leu Lys Phe Asn Leu Thr Glu Thr Pro Glu Arg Glu Ile 
            100                 105                 110         


His Gln Gly Phe Gln His Leu Leu Gln Met Leu Ser Arg Pro Ser Asn 
        115                 120                 125             


Glu Leu Gln Leu Ser Val Gly Asn Thr Met Phe Val Gln Glu Gln Leu 
    130                 135                 140                 


Lys Leu Leu Asp Lys Phe Arg Glu Asp Ala Leu Ala Leu Tyr Thr Ser 
145                 150                 155                 160 


Glu Ala Phe Ser Thr Asn Phe Lys Asp Pro Glu Thr Ala Lys Ser Leu 
                165                 170                 175     


Ile Asn Asp Tyr Val Lys Asn Lys Thr Arg Gly Lys Ile Val Asp Leu 
            180                 185                 190         


Phe Lys Asp Leu Asp Pro Leu Thr Lys Val Ile Leu Val Asn Tyr Ile 
        195                 200                 205             


Tyr Phe Lys Ala Gln Trp Arg Thr Pro Phe Asp Pro Lys Gln Thr Tyr 
    210                 215                 220                 


Lys Ser Gln Phe His Val Ser Lys Asn Lys Thr Val Glu Val Pro Met 
225                 230                 235                 240 


Met Ser Ile Gly Asp Leu Val Thr Pro Tyr Phe Arg Asp Glu Glu Leu 
                245                 250                 255     


Asp Cys Thr Leu Val Glu Leu Thr Tyr Thr Ser Asn Asp Ser Ala Leu 
            260                 265                 270         


Phe Ile Leu Pro Asp Glu Gly Lys Met Gln Asp Leu Glu Ala Lys Leu 
        275                 280                 285             


Ile Pro Glu Met Leu Thr Arg Trp Arg Glu Ser Leu Tyr Pro Arg Gly 
    290                 295                 300                 


Ile His Glu Leu Asn Leu Pro Arg Phe Ser Ile Ala Thr Asp Tyr Lys 
305                 310                 315                 320 


Leu Lys Asp Ile Leu Ser Gln Leu Glu Ile Lys Lys Val Phe Thr Gln 
                325                 330                 335     


Glu Ala Asp Leu Ser Gly Ile Thr Asp Asp His Glu Leu Glu Val Ser 
            340                 345                 350         


Gln Val Val His Lys Ala Val Leu Asp Val Gly Glu Glu Gly Thr Glu 
        355                 360                 365             


Gly Ala Ala Ala Thr Gly Val Lys Val Gly Ile Thr Ser Ile Asn Asn 
    370                 375                 380                 


His Ile Pro Leu Ser Phe Asn Arg Pro Phe Leu Ile Ala Ile Val Leu 
385                 390                 395                 400 


Lys Asp Thr Gln Ser Ile Ile Phe Leu Gly Lys Val Thr Asn Pro Ser 
                405                 410                 415     


Gln Ala 
        


<210>  9
<211>  423
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(423)
<223>  human serpin A3

<220>
<221>  SITE
<222>  (384)..(384)
<223>  trypsin cleavage site

<220>
<221>  SITE
<222>  (407)..(407)
<223>  caspase cleavage site

<400>  9

Met Glu Arg Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala Gly 
1               5                   10                  15      


Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu 
            20                  25                  30          


Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly 
        35                  40                  45              


Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu 
    50                  55                  60                  


Val Leu Lys Ala Pro Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile 
65                  70                  75                  80  


Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu 
                85                  90                  95      


Thr Glu Ile Leu Lys Gly Leu Lys Phe Asn Leu Thr Glu Thr Ser Glu 
            100                 105                 110         


Ala Glu Ile His Gln Ser Phe Gln His Leu Leu Arg Thr Leu Asn Gln 
        115                 120                 125             


Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val Lys 
    130                 135                 140                 


Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu 
145                 150                 155                 160 


Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala 
                165                 170                 175     


Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile 
            180                 185                 190         


Thr Asp Leu Ile Lys Asp Leu Asp Ser Gln Thr Met Met Val Leu Val 
        195                 200                 205             


Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln 
    210                 215                 220                 


Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val Met 
225                 230                 235                 240 


Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg Asp 
                245                 250                 255     


Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala 
            260                 265                 270         


Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val Glu 
        275                 280                 285             


Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu 
    290                 295                 300                 


Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg 
305                 310                 315                 320 


Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala 
                325                 330                 335     


Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu 
            340                 345                 350         


Ala Val Ser Gln Val Val His Lys Ala Val Leu Asp Val Phe Glu Glu 
        355                 360                 365             


Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Lys Ile Thr Leu Leu Ser 
    370                 375                 380                 


Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu 
385                 390                 395                 400 


Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys 
                405                 410                 415     


Val Thr Asn Pro Lys Gln Ala 
            420             


<210>  10
<211>  417
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(417)
<223>  human serpin A9

<220>
<221>  SITE
<222>  (377)..(377)
<223>  trypsin cleavage site

<220>
<221>  SITE
<222>  (403)..(403)
<223>  caspase cleavage site

<400>  10

Met Ala Ser Tyr Leu Tyr Gly Val Leu Phe Ala Val Gly Leu Cys Ala 
1               5                   10                  15      


Pro Ile Tyr Cys Val Ser Pro Ala Asn Ala Pro Ser Ala Tyr Pro Arg 
            20                  25                  30          


Pro Ser Ser Thr Lys Ser Thr Pro Ala Ser Gln Val Tyr Ser Leu Asn 
        35                  40                  45              


Thr Asp Phe Ala Phe Arg Leu Tyr Arg Arg Leu Val Leu Glu Thr Pro 
    50                  55                  60                  


Ser Gln Asn Ile Phe Phe Ser Pro Val Ser Val Ser Thr Ser Leu Ala 
65                  70                  75                  80  


Met Leu Ser Leu Gly Ala His Ser Val Thr Lys Thr Gln Ile Leu Gln 
                85                  90                  95      


Gly Leu Gly Phe Asn Leu Thr His Thr Pro Glu Ser Ala Ile His Gln 
            100                 105                 110         


Gly Phe Gln His Leu Val His Ser Leu Thr Val Pro Ser Lys Asp Leu 
        115                 120                 125             


Thr Leu Lys Met Gly Ser Ala Leu Phe Val Lys Lys Glu Leu Gln Leu 
    130                 135                 140                 


Gln Ala Asn Phe Leu Gly Asn Val Lys Arg Leu Tyr Glu Ala Glu Val 
145                 150                 155                 160 


Phe Ser Thr Asp Phe Ser Asn Pro Ser Ile Ala Gln Ala Arg Ile Asn 
                165                 170                 175     


Ser His Val Lys Lys Lys Thr Gln Gly Lys Val Val Asp Ile Ile Gln 
            180                 185                 190         


Gly Leu Asp Leu Leu Thr Ala Met Val Leu Val Asn His Ile Phe Phe 
        195                 200                 205             


Lys Ala Lys Trp Glu Lys Pro Phe His Pro Glu Tyr Thr Arg Lys Asn 
    210                 215                 220                 


Phe Pro Phe Leu Val Gly Glu Gln Val Thr Val His Val Pro Met Met 
225                 230                 235                 240 


His Gln Lys Glu Gln Phe Ala Phe Gly Val Asp Thr Glu Leu Asn Cys 
                245                 250                 255     


Phe Val Leu Gln Met Asp Tyr Lys Gly Asp Ala Val Ala Phe Phe Val 
            260                 265                 270         


Leu Pro Ser Lys Gly Lys Met Arg Gln Leu Glu Gln Ala Leu Ser Ala 
        275                 280                 285             


Arg Thr Leu Arg Lys Trp Ser His Ser Leu Gln Lys Arg Trp Ile Glu 
    290                 295                 300                 


Val Phe Ile Pro Arg Phe Ser Ile Ser Ala Ser Tyr Asn Leu Glu Thr 
305                 310                 315                 320 


Ile Leu Pro Lys Met Gly Ile Gln Asn Val Phe Asp Lys Asn Ala Asp 
                325                 330                 335     


Phe Ser Gly Ile Ala Lys Arg Asp Ser Leu Gln Val Ser Lys Ala Thr 
            340                 345                 350         


His Lys Ala Val Leu Asp Val Ser Glu Glu Gly Thr Glu Ala Thr Ala 
        355                 360                 365             


Ala Thr Thr Thr Lys Phe Ile Val Arg Ser Lys Asp Gly Pro Ser Tyr 
    370                 375                 380                 


Phe Thr Val Ser Phe Asn Arg Thr Phe Leu Met Met Ile Thr Asn Lys 
385                 390                 395                 400 


Ala Thr Asp Gly Ile Leu Phe Leu Gly Lys Val Glu Asn Pro Thr Lys 
                405                 410                 415     


Ser 
    


<210>  11
<211>  426
<212>  PRT
<213>  Sus scrofa


<220>
<221>  MISC_FEATURE
<222>  (1)..(426)
<223>  porcine serpin A31

<400>  11

Met Arg Ala Glu Gly Met Ser Leu Phe Leu Ala Leu Gly Leu Leu Val 
1               5                   10                  15      


Ala Gly Leu Cys Ser Arg Val His Cys Val Pro Ala Asp Asp Leu Ala 
            20                  25                  30          


Ser Lys Ile Val Thr Leu Lys Asp Gln Ile Lys Lys Leu Pro Val His 
        35                  40                  45              


Asn Thr Ala Val Val Ser Ser Asn Thr Asp Phe Ala Phe Ser Leu Tyr 
    50                  55                  60                  


Lys Gln Leu Ser Leu Thr Asn Arg His Lys Asn Ile Ile Phe Ser Pro 
65                  70                  75                  80  


Leu Ser Val Ser Met Ala Leu Phe Leu Ser Leu Gly Ala Arg Gly Pro 
                85                  90                  95      


Thr Leu Thr Glu Leu Leu Lys Ala Ser Ser Ser Cys His Arg Asp Ser 
            100                 105                 110         


Leu Arg Gln Lys Ser Thr Gln Gly Phe Gln His Leu Arg Gly Arg Ser 
        115                 120                 125             


Ile Arg Pro Ser Asn Leu Leu Gln Leu Arg Leu Gly Asn Ala Met Phe 
    130                 135                 140                 


Ile Asp Glu Gln Leu Glu Leu Val Asp Lys Phe Val Gln Asp Ala Arg 
145                 150                 155                 160 


Glu Leu Tyr His Ser Glu Ala Phe Pro Thr Asn Phe Gln Asp Leu Glu 
                165                 170                 175     


Ala Ala Arg Arg Leu Ile Asn Asp Tyr Val Lys Asn Lys Thr Glu Gly 
            180                 185                 190         


Lys Ile Val Glu Leu Ile Lys Arg Leu Ile Pro Val Thr Glu Ala Val 
        195                 200                 205             


Leu Val Asn Tyr Ile Tyr Phe Lys Ala Gln Trp Met Thr His Phe Asp 
    210                 215                 220                 


Pro Asn Leu Thr Thr Glu Ala Asp Phe Tyr Val Ser Lys Asn Arg Thr 
225                 230                 235                 240 


Val Arg Val Pro Met Met Ala Ile Lys Asn Leu Thr Val Pro Tyr Phe 
                245                 250                 255     


Arg Asp Glu Glu Leu Ala Cys Thr Val Val Glu Leu Pro Tyr Thr Ser 
            260                 265                 270         


Asn Asp Ser Thr Leu Phe Ile Leu Pro Asp Asp Gly Arg Met Ala Ala 
        275                 280                 285             


Val Glu Ala Lys Leu Leu Pro Glu Thr Leu Arg Arg Trp Arg Asp Ser 
    290                 295                 300                 


Leu Gln Pro Arg Arg Ile Glu Ala Leu His Leu Pro Arg Phe Ser Ile 
305                 310                 315                 320 


Ser Ser Asp Tyr Lys Leu Gln Glu Ile Leu Pro Arg Leu Gly Ile Gln 
                325                 330                 335     


Lys Ile Phe Ser Glu Glu Ala Asp Leu Ser Gly Ile Thr Asp Thr Thr 
            340                 345                 350         


Pro Leu Cys Val Ser Gln Val Val His Ser Ala Val Leu Asp Val Asp 
        355                 360                 365             


Glu Glu Gly Thr Glu Gly Ala Ala Ser Thr Gly Val Val Ile Glu Arg 
    370                 375                 380                 


Lys Ser Phe Glu Asn Phe Ile Val Arg Phe Asp Ser Pro Phe Leu Phe 
385                 390                 395                 400 


Ala Arg Ser Ser Glu Thr Pro Arg Ala Ser Ser Phe Trp Ala Lys Ser 
                405                 410                 415     


Ser Thr Pro Ile Gln Pro Arg Ala Pro Leu 
            420                 425     


<210>  12
<211>  415
<212>  PRT
<213>  Sus scrofa


<220>
<221>  MISC_FEATURE
<222>  (1)..(415)
<223>  porcine serpin A32

<400>  12

Met Ser Leu Phe Leu Ala Leu Gly Leu Leu Val Ala Gly Leu Cys Ser 
1               5                   10                  15      


Arg Val His Cys Val Pro Ala Asp Asp Pro Ala Ser Lys Ile Val Thr 
            20                  25                  30          


Leu Lys Asp Gln Ile Lys Lys Leu Pro Ala His Asn Thr Ala Val Val 
        35                  40                  45              


Ser Ser Asn Thr Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu Ala Leu 
    50                  55                  60                  


Thr Asn Pro His Glu Asn Val Ile Phe Ser Pro Leu Ser Val Ser Met 
65                  70                  75                  80  


Ala Leu Ala Phe Leu Ser Leu Gly Ala Arg Gly Pro Thr Leu Thr Glu 
                85                  90                  95      


Leu Leu Glu Gly Leu Lys Phe Asn Leu Thr Lys Thr Pro Glu Ala Glu 
            100                 105                 110         


Ile His Gln Gly Phe Gln His Leu Leu Ser Thr Leu Asp Arg Ser Ser 
        115                 120                 125             


Asn Leu Leu Gln Leu Arg Leu Gly Asn Ala Met Phe Ile Asp Glu Gln 
    130                 135                 140                 


Leu Glu Leu Leu Asp Lys Phe Val Gln Asp Ala His Glu Leu Tyr His 
145                 150                 155                 160 


Ser Glu Ala Phe Pro Thr Asn Phe Gln Asp Leu Glu Ala Ala Arg Arg 
                165                 170                 175     


Leu Ile Asn Asp Tyr Val Lys Asn Lys Thr Glu Gly Lys Ile Val Asp 
            180                 185                 190         


Leu Phe Lys Lys Leu Asp Pro Leu Thr Lys Val Val Leu Val Asn Tyr 
        195                 200                 205             


Ile Tyr Phe Lys Ala Lys Trp Lys Thr Pro Phe Asn Pro Asn Leu Thr 
    210                 215                 220                 


Thr Glu Ala Asp Phe His Val Ser Lys Asn Arg Thr Val Arg Val Pro 
225                 230                 235                 240 


Met Met Gly Ile Arg Ala Leu Thr Val Pro Tyr Phe Arg Asp Glu Glu 
                245                 250                 255     


Leu Ala Cys Thr Val Val Glu Leu Pro Tyr Thr Ser Asn Asp Ser Ala 
            260                 265                 270         


Leu Phe Ile Leu Pro Asp Asp Gly Arg Met Ala Ala Val Glu Ala Lys 
        275                 280                 285             


Leu Leu Pro Glu Thr Leu Arg Arg Trp Arg Asp Phe Leu Gln Pro Arg 
    290                 295                 300                 


Trp Ile Val Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Ser Asp Tyr 
305                 310                 315                 320 


Arg Leu His Glu Ile Leu Pro Gln Leu Gly Ile Glu Glu Ile Phe Gly 
                325                 330                 335     


Asp Asn Ala Asn Leu Ser Gly Ile Thr Asn Thr Lys Pro Leu Lys Val 
            340                 345                 350         


Ser Gln Val Val His Ser Ala Val Leu Asp Val Asn Glu Glu Gly Thr 
        355                 360                 365             


Glu Ala Ala Ala Ala Thr Gly Ile Asp Ile Asn Val Arg Ser Leu Glu 
    370                 375                 380                 


Arg Ile Ala Leu His Phe Asn Arg Pro Phe Leu Phe Val Ile Ile Ser 
385                 390                 395                 400 


Lys Asp Ile Gln Ser Ile Ile Phe Leu Gly Lys Val Thr Lys Pro 
                405                 410                 415 


<210>  13
<211>  418
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(418)
<223>  murine serpin A3N

<400>  13

Met Ala Phe Ile Ala Ala Leu Gly Leu Leu Met Ala Gly Ile Cys Pro 
1               5                   10                  15      


Ala Val Leu Cys Phe Pro Asp Gly Thr Leu Gly Met Asp Ala Ala Val 
            20                  25                  30          


Gln Glu Asp His Asp Asn Gly Thr Gln Leu Asp Ser Leu Thr Leu Ala 
        35                  40                  45              


Ser Ile Asn Thr Asp Phe Ala Phe Ser Leu Tyr Lys Glu Leu Val Leu 
    50                  55                  60                  


Lys Asn Pro Asp Lys Asn Ile Val Phe Ser Pro Leu Ser Ile Ser Ala 
65                  70                  75                  80  


Ala Leu Ala Val Met Ser Leu Gly Ala Lys Gly Asn Thr Leu Glu Glu 
                85                  90                  95      


Ile Leu Glu Gly Leu Lys Phe Asn Leu Thr Glu Thr Ser Glu Ala Asp 
            100                 105                 110         


Ile His Gln Gly Phe Gly His Leu Leu Gln Arg Leu Asn Gln Pro Lys 
        115                 120                 125             


Asp Gln Val Gln Ile Ser Thr Gly Ser Ala Leu Phe Ile Glu Lys Arg 
    130                 135                 140                 


Gln Gln Ile Leu Thr Glu Phe Gln Glu Lys Ala Lys Thr Leu Tyr Gln 
145                 150                 155                 160 


Ala Glu Ala Phe Thr Ala Asp Phe Gln Gln Pro Arg Gln Ala Lys Lys 
                165                 170                 175     


Leu Ile Asn Asp Tyr Val Arg Lys Gln Thr Gln Gly Met Ile Lys Glu 
            180                 185                 190         


Leu Val Ser Asp Leu Asp Lys Arg Thr Leu Met Val Leu Val Asn Tyr 
        195                 200                 205             


Ile Tyr Phe Lys Ala Lys Trp Lys Val Pro Phe Asp Pro Leu Asp Thr 
    210                 215                 220                 


Phe Lys Ser Glu Phe Tyr Ala Gly Lys Arg Arg Pro Val Ile Val Pro 
225                 230                 235                 240 


Met Met Ser Met Glu Asp Leu Thr Thr Pro Tyr Phe Arg Asp Glu Glu 
                245                 250                 255     


Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala Ser Ala 
            260                 265                 270         


Leu Phe Ile Leu Pro Asp Gln Gly Arg Met Gln Gln Val Glu Ala Ser 
        275                 280                 285             


Leu Gln Pro Glu Thr Leu Arg Lys Trp Lys Asn Ser Leu Lys Pro Arg 
    290                 295                 300                 


Met Ile Asp Glu Leu His Leu Pro Lys Phe Ser Ile Ser Thr Asp Tyr 
305                 310                 315                 320 


Ser Leu Glu Asp Val Leu Ser Lys Leu Gly Ile Arg Glu Val Phe Ser 
                325                 330                 335     


Thr Gln Ala Asp Leu Ser Ala Ile Thr Gly Thr Lys Asp Leu Arg Val 
            340                 345                 350         


Ser Gln Val Val His Lys Ala Val Leu Asp Val Ala Glu Thr Gly Thr 
        355                 360                 365             


Glu Ala Ala Ala Ala Thr Gly Val Lys Phe Val Pro Met Ser Ala Lys 
    370                 375                 380                 


Leu Tyr Pro Leu Thr Val Tyr Phe Asn Arg Pro Phe Leu Ile Met Ile 
385                 390                 395                 400 


Phe Asp Thr Glu Thr Glu Ile Ala Pro Phe Ile Ala Lys Ile Ala Asn 
                405                 410                 415     


Pro Lys 
        


<210>  14
<211>  418
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(418)
<223>  murine serpin A9

<400>  14

Met Gly Ser Ser Ser Phe Tyr Arg Val Leu Leu Leu Val Gly Phe Cys 
1               5                   10                  15      


Ala Pro Ile Phe Cys Met Leu Ser Ser Asn Pro Tyr Asn Gln Glu Ser 
            20                  25                  30          


Ser His Leu Pro Ser Met Lys Lys Asn Pro Ala Ser Gln Val Ser Pro 
        35                  40                  45              


Ser Asn Thr Arg Phe Ser Phe Leu Leu Tyr Gln Arg Leu Ala Gln Glu 
    50                  55                  60                  


Asn Pro Gly Gln Asn Ile Leu Phe Ser Pro Val Ser Ile Ser Thr Ser 
65                  70                  75                  80  


Leu Ala Met Leu Ser Leu Gly Ala Arg Ser Ala Thr Lys Thr Gln Ile 
                85                  90                  95      


Leu Arg Thr Leu Gly Phe Asn Phe Thr Trp Val Ser Glu Pro Thr Ile 
            100                 105                 110         


His Met Gly Phe Glu Tyr Leu Val Arg Ser Leu Asn Lys Cys His Gln 
        115                 120                 125             


Gly Arg Glu Leu Arg Met Gly Ser Val Leu Phe Ile Arg Lys Glu Leu 
    130                 135                 140                 


Gln Leu Gln Ala Thr Phe Leu Asp Arg Val Lys Lys Leu Tyr Gly Ala 
145                 150                 155                 160 


Lys Val Phe Ser Glu Asp Phe Ser Asn Ala Ala Thr Ala Gln Ala Gln 
                165                 170                 175     


Ile Asn Ser Tyr Val Glu Lys Glu Thr Lys Gly Lys Val Val Asp Val 
            180                 185                 190         


Ile Gln Asp Leu Asp Ser Gln Thr Ala Met Val Leu Val Asn His Ile 
        195                 200                 205             


Phe Phe Lys Ala Asn Trp Thr Gln Pro Phe Ser Thr Ala Asn Thr Asn 
    210                 215                 220                 


Lys Ser Phe Pro Phe Leu Leu Ser Lys Gly Thr Thr Val His Val Pro 
225                 230                 235                 240 


Met Met His Gln Thr Glu Ser Phe Ala Phe Gly Val Asp Lys Glu Leu 
                245                 250                 255     


Gly Cys Ser Ile Leu Gln Met Asp Tyr Arg Gly Asp Ala Val Ala Phe 
            260                 265                 270         


Phe Val Leu Pro Gly Lys Gly Lys Met Arg Gln Leu Glu Lys Ser Leu 
        275                 280                 285             


Ser Ala Arg Arg Leu Arg Lys Trp Ser Arg Ser Leu Gln Lys Arg Trp 
    290                 295                 300                 


Ile Lys Val Phe Ile Pro Lys Phe Ser Ile Ser Ala Ser Tyr Asn Leu 
305                 310                 315                 320 


Glu Thr Ile Leu Pro Lys Met Gly Ile Arg Asp Ala Phe Asn Ser Asn 
                325                 330                 335     


Ala Asp Phe Ser Gly Ile Thr Lys Thr His Phe Leu Gln Val Ser Lys 
            340                 345                 350         


Ala Ala His Lys Ala Val Leu Asp Val Ser Glu Glu Gly Thr Glu Ala 
        355                 360                 365             


Ala Ala Ala Thr Thr Thr Lys Leu Ile Val Arg Ser Arg Asp Thr Pro 
    370                 375                 380                 


Ser Ser Ile Ile Ala Phe Lys Glu Pro Phe Leu Ile Leu Leu Leu Asp 
385                 390                 395                 400 


Lys Asn Thr Glu Ser Val Leu Phe Leu Gly Lys Val Glu Asn Pro Arg 
                405                 410                 415     


Lys Met 
        


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beginning of RCL


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Glu or Thr

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Gly or Ala

<400>  15

Glu Xaa Gly Thr Glu Xaa 
1               5       


<210>  16
<211>  53
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(53)
<223>  RCL of bovine SERPINA3-1

<400>  16

Glu Glu Gly Thr Glu Gly Ala Ala Ala Thr Gly Ile Ser Met Glu Arg 
1               5                   10                  15      


Thr Ile Leu Arg Ile Ile Val Arg Val Asn Arg Pro Phe Leu Ile Ala 
            20                  25                  30          


Ile Val Leu Lys Asp Thr Gln Ser Ile Ile Phe Leu Gly Lys Val Thr 
        35                  40                  45              


Asn Pro Ser Glu Ala 
    50              


<210>  17
<211>  53
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(53)
<223>  RCL of bovine SERPINA3-2

<400>  17

Glu Glu Gly Thr Glu Gly Val Ala Ala Thr Gly Ile Gly Ile Glu Arg 
1               5                   10                  15      


Thr Phe Leu Arg Ile Ile Val Arg Val Asn Arg Pro Phe Leu Ile Ala 
            20                  25                  30          


Val Val Leu Lys Asp Thr Gln Ser Ile Ile Phe Leu Gly Lys Val Thr 
        35                  40                  45              


Asn Pro Ser Glu Ala 
    50              


<210>  18
<211>  53
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(53)
<223>  RCL of bovine SERPINA3-3

<400>  18

Glu Glu Gly Thr Glu Gly Ala Ala Ala Thr Gly Ile Gly Ile Glu Arg 
1               5                   10                  15      


Thr Phe Leu Arg Ile Ile Val Arg Val Asn Arg Pro Phe Leu Ile Ala 
            20                  25                  30          


Val Val Leu Lys Asp Thr Gln Ser Ile Ile Phe Leu Gly Lys Val Thr 
        35                  40                  45              


Asn Pro Ser Glu Ala 
    50              


<210>  19
<211>  53
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(53)
<223>  RCL of SERPINA3-4

<400>  19

Glu Glu Gly Thr Glu Gly Ala Ala Ala Thr Gly Ile Gly Ile Glu Arg 
1               5                   10                  15      


Thr Phe Leu Arg Ile Ile Val Arg Val Asn Arg Pro Phe Leu Ile Ala 
            20                  25                  30          


Val Val Leu Lys Asp Thr Gln Ser Ile Ile Phe Leu Gly Lys Val Thr 
        35                  40                  45              


Asn Pro Ser Glu Ala 
    50              


<210>  20
<211>  53
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(53)
<223>  RCL of bovine SERPINA3-5

<400>  20

Glu Glu Gly Thr Glu Gly Ala Ala Ala Thr Gly Ile Gly Ile Glu Arg 
1               5                   10                  15      


Thr Phe Leu Arg Ile Ile Val Arg Val Asn Arg Pro Phe Leu Ile Ala 
            20                  25                  30          


Val Val Leu Lys Asp Thr Gln Ser Ile Ile Phe Leu Gly Lys Val Thr 
        35                  40                  45              


Asn Pro Ser Glu Ala 
    50              


<210>  21
<211>  53
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(53)
<223>  RCL of bovine SERPINA3-6

<400>  21

Glu Glu Gly Thr Glu Gly Ala Ala Ala Thr Gly Ile Gly Ile Glu Arg 
1               5                   10                  15      


Thr Phe Leu Arg Ile Ile Val Arg Val Asn Arg Pro Phe Leu Ile Ala 
            20                  25                  30          


Val Val Leu Lys Asp Thr Gln Ser Ile Ile Phe Leu Gly Lys Val Thr 
        35                  40                  45              


Asn Pro Ser Glu Ala 
    50              


<210>  22
<211>  55
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(55)
<223>  RCL of bovine SERPINA3-7

<400>  22

Glu Glu Gly Thr Glu Gly Ala Ala Val Thr Ala Val Val Met Ala Thr 
1               5                   10                  15      


Ser Ser Leu Leu His Thr Leu Thr Val Ser Phe Asn Arg Pro Phe Leu 
            20                  25                  30          


Leu Ser Ile Phe Cys Lys Glu Thr Gln Ser Ile Ile Phe Leu Gly Lys 
        35                  40                  45              


Val Thr Asn Pro Lys Glu Ala 
    50                  55  


<210>  23
<211>  55
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(55)
<223>  RCL of bovine SERPINA3-8

<400>  23

Glu Glu Gly Thr Glu Gly Ala Ala Ala Thr Gly Val Lys Val Gly Ile 
1               5                   10                  15      


Thr Ser Ile Asn Asn His Ile Pro Leu Ser Phe Asn Arg Pro Phe Leu 
            20                  25                  30          


Ile Ala Ile Val Leu Lys Asp Thr Gln Ser Ile Ile Phe Leu Gly Lys 
        35                  40                  45              


Val Thr Asn Pro Ser Gln Ala 
    50                  55  


<210>  24
<211>  57
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(57)
<223>  RCL of human serpin A3

<400>  24

Glu Glu Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Lys Ile Thr Leu 
1               5                   10                  15      


Leu Ser Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro 
            20                  25                  30          


Phe Leu Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met 
        35                  40                  45              


Ser Lys Val Thr Asn Pro Lys Gln Ala 
    50                  55          


<210>  25
<211>  57
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(57)
<223>  RCL of human serpin A9

<400>  25

Glu Glu Gly Thr Glu Ala Thr Ala Ala Thr Thr Thr Lys Phe Ile Val 
1               5                   10                  15      


Arg Ser Lys Asp Gly Pro Ser Tyr Phe Thr Val Ser Phe Asn Arg Thr 
            20                  25                  30          


Phe Leu Met Met Ile Thr Asn Lys Ala Thr Asp Gly Ile Leu Phe Leu 
        35                  40                  45              


Gly Lys Val Glu Asn Pro Thr Lys Ser 
    50                  55          


<210>  26
<211>  58
<212>  PRT
<213>  Sus scrofa


<220>
<221>  MISC_FEATURE
<222>  (1)..(58)
<223>  RCL of procine serpin A31

<400>  26

Glu Glu Gly Thr Glu Gly Ala Ala Ser Thr Gly Val Val Ile Glu Arg 
1               5                   10                  15      


Lys Ser Phe Glu Asn Phe Ile Val Arg Phe Asp Ser Pro Phe Leu Phe 
            20                  25                  30          


Ala Arg Ser Ser Glu Thr Pro Arg Ala Ser Ser Phe Trp Ala Lys Ser 
        35                  40                  45              


Ser Thr Pro Ile Gln Pro Arg Ala Pro Leu 
    50                  55              


<210>  27
<211>  51
<212>  PRT
<213>  Sus scrofa


<220>
<221>  MISC_FEATURE
<222>  (1)..(51)
<223>  RCL of porcine serpin A32

<400>  27

Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Gly Ile Asp Ile Asn Val 
1               5                   10                  15      


Arg Ser Leu Glu Arg Ile Ala Leu His Phe Asn Arg Pro Phe Leu Phe 
            20                  25                  30          


Val Ile Ile Ser Lys Asp Ile Gln Ser Ile Ile Phe Leu Gly Lys Val 
        35                  40                  45              


Thr Lys Pro 
    50      


<210>  28
<211>  54
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(54)
<223>  RCL of murine serpin A3N

<400>  28

Glu Thr Gly Thr Glu Ala Ala Ala Ala Thr Gly Val Lys Phe Val Pro 
1               5                   10                  15      


Met Ser Ala Lys Leu Tyr Pro Leu Thr Val Tyr Phe Asn Arg Pro Phe 
            20                  25                  30          


Leu Ile Met Ile Phe Asp Thr Glu Thr Glu Ile Ala Pro Phe Ile Ala 
        35                  40                  45              


Lys Ile Ala Asn Pro Lys 
    50                  


<210>  29
<211>  56
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(56)
<223>  RCL of murine serpin A9

<400>  29

Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Thr Thr Lys Leu Ile Val 
1               5                   10                  15      


Arg Ser Arg Asp Thr Pro Ser Ser Ile Ile Ala Phe Lys Glu Pro Phe 
            20                  25                  30          


Leu Ile Leu Leu Leu Asp Lys Asn Thr Glu Ser Val Leu Phe Leu Gly 
        35                  40                  45              


Lys Val Glu Asn Pro Arg Lys Met 
    50                  55      


<210>  30
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 1 cleavage site 1

<400>  30

Tyr Val His Asp Ala 
1               5   


<210>  31
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 1 cleavage site 2

<400>  31

Glu Ala Asp Gly 
1               


<210>  32
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 1 cleavage site 3

<400>  32

Tyr Val Ala Asp 
1               


<210>  33
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 1 cleavage site 4


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  33

Tyr Glu Val Asp Xaa 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 1 cleavage site 5


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  34

Trp Glu His Asp Xaa 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 2 cleavage site 1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  35

Asp Val Ala Asp Xaa 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 2 cleavage site 2


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  36

Asp Glu His Asp Xaa 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 3 cleavage site 1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  37

Asp Met Gln Asp Xaa 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 3 cleavage site 2


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  38

Asp Glu Val Asp Xaa 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 4 cleavage site 1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  39

Leu Glu Val Asp Xaa 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 4 cleavage site 2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Trp or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  40

Xaa Glu His Asp Xaa 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 6 cleavage site 1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  41

Val Glu Ile Asp Xaa 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 6 cleavage site 2


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  42

Val Glu His Asp Xaa 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 8 cleavage site 1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  43

Ile Glu Thr Asp Xaa 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 8 cleavage site 2


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  44

Leu Glu Thr Asp Xaa 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 9 cleavage site


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  45

Leu Glu His Asp Xaa 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 10 cleavage site


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid but Pro, Glu, Asp, 
       Gln, Lys or Arg

<400>  46

Ile Glu Ala Asp Xaa 
1               5   


<210>  47
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  peptide 1

<400>  47

Phe Leu Ile Ala Val Val Leu 
1               5           


<210>  48
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  peptide 2

<400>  48

Ala Thr Gly Ile Gly Ile 
1               5       


<210>  49
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide 3

<400>  49

Phe Leu Met Met Ile Thr Asn Lys Ala 
1               5                   


<210>  50
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  peptide 4

<400>  50

Asn Arg Pro Phe Leu Met Ile Ile Val Gly 
1               5                   10  


