                         SEQUENCE LISTING

<110>  ZECHNER, Rudolf
       ZIMMERMANN, Robert
       HMMERLE, Gnter
       LASS, Achim
       DAS, Suman
       HFLER, Gerald
 
<120>  Modulation of adipose triglyceride lipase for prevention and 
       treatment of cachexia, loss of weight and muscle atrophy and 
       methods of screening therefor

<130>  S1346 PCT S3

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  504
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Phe Pro Arg Glu Lys Thr Trp Asn Ile Ser Phe Ala Gly Cys Gly 
1               5                   10                  15      


Phe Leu Gly Val Tyr Tyr Val Gly Val Ala Ser Cys Leu Arg Glu His 
            20                  25                  30          


Ala Pro Phe Leu Val Ala Asn Ala Thr His Ile Tyr Gly Ala Ser Ala 
        35                  40                  45              


Gly Ala Leu Thr Ala Thr Ala Leu Val Thr Gly Val Cys Leu Gly Glu 
    50                  55                  60                  


Ala Gly Ala Lys Phe Ile Glu Val Ser Lys Glu Ala Arg Lys Arg Phe 
65                  70                  75                  80  


Leu Gly Pro Leu His Pro Ser Phe Asn Leu Val Lys Ile Ile Arg Ser 
                85                  90                  95      


Phe Leu Leu Lys Val Leu Pro Ala Asp Ser His Glu His Ala Ser Gly 
            100                 105                 110         


Arg Leu Gly Ile Ser Leu Thr Arg Val Ser Asp Gly Glu Asn Val Ile 
        115                 120                 125             


Ile Ser His Phe Asn Ser Lys Asp Glu Leu Ile Gln Ala Asn Val Cys 
    130                 135                 140                 


Ser Gly Phe Ile Pro Val Tyr Cys Gly Leu Ile Pro Pro Ser Leu Gln 
145                 150                 155                 160 


Gly Val Arg Tyr Val Asp Gly Gly Ile Ser Asp Asn Leu Pro Leu Tyr 
                165                 170                 175     


Glu Leu Lys Asn Thr Ile Thr Val Ser Pro Phe Ser Gly Glu Ser Asp 
            180                 185                 190         


Ile Cys Pro Gln Asp Ser Ser Thr Asn Ile His Glu Leu Arg Val Thr 
        195                 200                 205             


Asn Thr Ser Ile Gln Phe Asn Leu Arg Asn Leu Tyr Arg Leu Ser Lys 
    210                 215                 220                 


Ala Leu Phe Pro Pro Glu Pro Leu Val Leu Arg Glu Met Cys Lys Gln 
225                 230                 235                 240 


Gly Tyr Arg Asp Gly Leu Arg Phe Leu Gln Arg Asn Gly Leu Leu Asn 
                245                 250                 255     


Arg Pro Asn Pro Leu Leu Ala Leu Pro Pro Ala Arg Pro His Gly Pro 
            260                 265                 270         


Glu Asp Lys Asp Gln Ala Val Glu Ser Ala Gln Ala Glu Asp Tyr Ser 
        275                 280                 285             


Gln Leu Pro Gly Glu Asp His Ile Leu Glu His Leu Pro Ala Arg Leu 
    290                 295                 300                 


Asn Glu Ala Leu Leu Glu Ala Cys Val Glu Pro Thr Asp Leu Leu Thr 
305                 310                 315                 320 


Thr Leu Ser Asn Met Leu Pro Val Arg Leu Ala Thr Ala Met Met Val 
                325                 330                 335     


Pro Tyr Thr Leu Pro Leu Glu Ser Ala Leu Ser Phe Thr Ile Arg Leu 
            340                 345                 350         


Leu Glu Trp Leu Pro Asp Val Pro Glu Asp Ile Arg Trp Met Lys Glu 
        355                 360                 365             


Gln Thr Gly Ser Ile Cys Gln Tyr Leu Val Met Arg Ala Lys Arg Lys 
    370                 375                 380                 


Leu Gly Arg His Leu Pro Ser Arg Leu Pro Glu Gln Val Glu Leu Arg 
385                 390                 395                 400 


Arg Val Gln Ser Leu Pro Ser Val Pro Leu Ser Cys Ala Ala Tyr Arg 
                405                 410                 415     


Glu Ala Leu Pro Gly Trp Met Arg Asn Asn Leu Ser Leu Gly Asp Ala 
            420                 425                 430         


Leu Ala Lys Trp Glu Glu Cys Gln Arg Gln Leu Leu Leu Gly Leu Phe 
        435                 440                 445             


Cys Thr Asn Val Ala Phe Pro Pro Glu Ala Leu Arg Met Arg Ala Pro 
    450                 455                 460                 


Ala Asp Pro Ala Pro Ala Pro Ala Asp Pro Ala Ser Pro Gln His Gln 
465                 470                 475                 480 


Leu Ala Gly Pro Ala Pro Leu Leu Ser Thr Pro Ala Pro Glu Ala Arg 
                485                 490                 495     


Pro Val Ile Gly Ala Leu Gly Leu 
            500                 


<210>  2
<211>  2113
<212>  DNA
<213>  Homo sapiens

<400>  2
gcggccccag tcagacgcag gcagccccaa agcctgaaca ggcagggcca gacccagctt     60

cttcgcctcc gccagcgggg accccgagct agagccgcag cgggacctgc ccggcccccg    120

gctccagcga gcgagcggcg agcaggcggc tcacagaggc ctggccgccc acggaacccg    180

gggcccggcg gccgccgccg cgatgtttcc ccgcgagaag acgtggaaca tctcgttcgc    240

gggctgcggc ttcctcggcg tctactacgt cggcgtggcc tcctgcctcc gcgagcacgc    300

gcccttcctg gtggccaacg ccacgcacat ctacggcgcc tcggccgggg cgctcacggc    360

cacggcgctg gtcaccgggg tctgcctggg tgaggctggt gccaagttca ttgaggtatc    420

taaagaggcc cggaagcggt tcctgggccc cctgcacccc tccttcaacc tggtaaagat    480

catccgcagt ttcctgctga aggtcctgcc tgctgatagc catgagcatg ccagtgggcg    540

cctgggcatc tccctgaccc gcgtgtcaga cggcgagaat gtcattatat cccacttcaa    600

ctccaaggac gagctcatcc aggccaatgt ctgcagcggt ttcatccccg tgtactgtgg    660

gctcatccct ccctccctcc agggggtgcg ctacgtggat ggtggcattt cagacaacct    720

gccactctat gagcttaaga acaccatcac agtgtccccc ttctcgggcg agagtgacat    780

ctgtccgcag gacagctcca ccaacatcca cgagctgcgg gtcaccaaca ccagcatcca    840

gttcaacctg cgcaacctct accgcctctc caaggccctc ttcccgccgg agcccctggt    900

gctgcgagag atgtgcaagc agggataccg ggatggcctg cgctttctgc agcggaacgg    960

cctcctgaac cggcccaacc ccttgctggc gttgcccccc gcccgccccc acggcccaga   1020

ggacaaggac caggcagtgg agagcgccca agcggaggat tactcgcagc tgccgggaga   1080

agatcacatc ctggagcacc tgcccgcccg gctcaatgag gccctgctgg aggcctgcgt   1140

ggagcccacg gacctgctga ccaccctctc caacatgctg cctgtgcgtc tggccacggc   1200

catgatggtg ccctacacgc tgccgctgga gagcgctctg tccttcacca tccgcttgct   1260

ggagtggctg cccgacgttc ccgaggacat ccggtggatg aaggagcaga cgggcagcat   1320

ctgccagtac ctggtgatgc gcgccaagag gaagctgggc aggcacctgc cctccaggct   1380

gccggagcag gtggagctgc gccgcgtcca gtcgctgccg tccgtgccgc tgtcctgcgc   1440

cgcctacaga gaggcactgc ccggctggat gcgcaacaac ctctcgctgg gggacgcgct   1500

ggccaagtgg gaggagtgcc agcgccagct gctgctcggc ctcttctgca ccaacgtggc   1560

cttcccgccc gaagctctgc gcatgcgcgc acccgccgac ccggctcccg cccccgcgga   1620

cccagcatcc ccgcagcacc agctggccgg gcctgccccc ttgctgagca cccctgctcc   1680

cgaggcccgg cccgtgatcg gggccctggg gctgtgagac cccgaccctc tcgaggaacc   1740

ctgcctgaga cgcctccatt accactgcgc agtgagatga ggggactcac agttgccaag   1800

aggggtcttt gccgtgggcc ccctcgccag ccactcacca gctgcatgca ctgagagggg   1860

aggtttccac acccctcccc tgggccgctg aggccccgcg cacctgtgcc ttaatcttcc   1920

ctcccctgtg ctgcccgagc acctcccccg cccctttact cctgagaact ttgcagctgc   1980

ccttccctcc ccgtttttca tggcctgctg aaatatgtgt gtgaagaatt atttattttc   2040

gccaaagcac atgtaataaa tgctgcagcc caaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2100

aaaaaaaaaa aaa                                                      2113


<210>  3
<211>  430
<212>  PRT
<213>  Mus musculus

<400>  3

Met Phe Thr Arg Glu Thr Lys Trp Asn Ile Ser Phe Ala Gly Cys Gly 
1               5                   10                  15      


Phe Leu Gly Val Tyr His Ile Gly Val Ala Ser Cys Leu Arg Glu His 
            20                  25                  30          


Ala Pro Phe Leu Val Ala Asn Ala Thr His Ile Tyr Gly Ala Ser Ala 
        35                  40                  45              


Gly Ala Leu Thr Ala Thr Ala Leu Val Thr Gly Ala Cys Leu Gly Glu 
    50                  55                  60                  


Ala Gly Ala Asn Ile Ile Glu Val Ser Lys Glu Ala Arg Lys Arg Phe 
65                  70                  75                  80  


Leu Gly Pro Leu His Pro Ser Phe Asn Leu Val Lys Thr Ile Arg Gly 
                85                  90                  95      


Cys Leu Leu Lys Thr Leu Pro Ala Asp Cys His Glu Arg Ala Asn Gly 
            100                 105                 110         


Arg Leu Gly Ile Ser Leu Thr Arg Val Ser Asp Gly Glu Asn Val Ile 
        115                 120                 125             


Ile Ser His Phe Ser Ser Lys Asp Glu Leu Ile Gln Ala Asn Val Cys 
    130                 135                 140                 


Ser Thr Phe Ile Pro Val Tyr Cys Gly Leu Ile Pro Pro Thr Leu Gln 
145                 150                 155                 160 


Gly Val Arg Tyr Val Asp Gly Gly Ile Ser Asp Asn Leu Pro Leu Tyr 
                165                 170                 175     


Glu Leu Lys Asn Thr Ile Thr Val Ser Pro Phe Ser Gly Glu Ser Asp 
            180                 185                 190         


Ile Cys Pro Gln Asp Ser Ser Thr Asn Ile His Glu Leu Arg Val Thr 
        195                 200                 205             


Asn Thr Ser Ile Gln Phe Asn Leu Arg Asn Leu Tyr Arg Leu Ser Lys 
    210                 215                 220                 


Ala Leu Phe Pro Pro Glu Pro Met Val Leu Arg Glu Met Cys Lys Gln 
225                 230                 235                 240 


Gly Tyr Arg Asp Gly Leu Arg Phe Leu Arg Arg Asn Ala Leu Leu Glu 
                245                 250                 255     


Ala Cys Val Glu Pro Lys Asp Leu Met Thr Thr Leu Ser Asn Met Leu 
            260                 265                 270         


Pro Val Arg Leu Ala Thr Ala Met Met Val Pro Tyr Thr Leu Pro Leu 
        275                 280                 285             


Glu Ser Ala Val Ser Phe Thr Ile Arg Leu Leu Glu Trp Leu Pro Asp 
    290                 295                 300                 


Val Pro Glu Asp Ile Arg Trp Met Lys Glu Gln Thr Gly Ser Ile Cys 
305                 310                 315                 320 


Gln Tyr Leu Val Met Arg Ala Lys Arg Lys Leu Gly Asp His Leu Pro 
                325                 330                 335     


Ser Arg Leu Ser Glu Gln Val Glu Leu Arg Arg Ala Gln Ser Leu Pro 
            340                 345                 350         


Ser Val Pro Leu Ser Cys Ala Thr Tyr Ser Glu Ala Leu Pro Asn Trp 
        355                 360                 365             


Val Arg Asn Asn Leu Ser Leu Gly Asp Ala Leu Ala Lys Trp Glu Glu 
    370                 375                 380                 


Cys Gln Arg Gln Leu Leu Leu Gly Leu Phe Cys Thr Asn Val Ala Phe 
385                 390                 395                 400 


Pro Pro Asp Ala Leu Arg Met Arg Ala Pro Ala Ser Pro Thr Ala Ala 
                405                 410                 415     


Asp Pro Ala Thr Pro Gln Asp Pro Pro Gly Leu Pro Pro Cys 
            420                 425                 430 


<210>  4
<211>  1799
<212>  DNA
<213>  Mus musculus

<400>  4
acagcgtctc cgcctccgcc ggcggagacc ccaaggtatc gagactgcgg gacccactgc     60

ccgcaggaca tcgagtcacg atgttcacga gggagaccaa gtggaacatc tcattcgctg    120

gctgcggctt cctcggggtc taccacattg gcgtggcctc ctgcctccgt gagcacgcgc    180

ccttcctggt ggccaacgcc actcacatct acggagcctc ggcaggggcg ctcaccgcca    240

cagcgctggt cactggggcc tgcctgggtg aagcaggtgc caacattatt gaggtgtcca    300

aggaggcccg gaagcggttc ctgggtcctc tgcatccctc cttcaacctg gtgaagacca    360

tccgtggctg tctactaaag accctgcctg ctgattgcca tgagcgcgcc aatggacgcc    420

tgggcatctc cctgactcgt gtttcagacg gagagaacgt catcatatcc cactttagct    480

ccaaggatga gctcatccag gccaatgtct gcagcacatt tatcccggtg tactgtggcc    540

tcattcctcc taccctccaa ggggtgcgct atgtggatgg cggcatttca gacaacttgc    600

cactttatga gctgaagaat accatcacag tgtccccatt ctcaggcgag agtgacatct    660

gccctcagga cagctccacc aacatccacg agcttcgcgt caccaacacc agcatccagt    720

tcaaccttcg caatctctac cgcctctcga aggctctctt cccgccagag cccatggtcc    780

tccgagagat gtgcaaacag ggctacagag atggacttcg attccttagg aggaatgccc    840

tgctggaggc ctgtgtggaa ccaaaggacc tgatgaccac cctttccaac atgctaccag    900

tgcgcctggc aacggccatg atggtgccct atactctgcc gctggagagt gcagtgtcct    960

tcaccatccg cttgttggag tggctgcctg atgtccctga agatatccgg tggatgaaag   1020

agcagacggg tagcatctgc cagtatctgg tgatgagggc caagaggaaa ttgggtgacc   1080

atctgccttc cagactgtct gagcaggtgg aactgcgacg tgcccagtct ctgccctctg   1140

tgccactgtc ttgcgccacc tacagtgagg ccctacccaa ctgggtacga aacaacctct   1200

cactggggga cgcgctggcc aagtgggaag aatgccagcg tcagctactg ctgggtctct   1260

tctgcaccaa tgtggccttc ccgccggatg ccttgcgcat gcgcgcacct gccagcccca   1320

ctgccgcaga tcctgccacc ccacaggatc cacctggcct cccgccttgc tgagaatcac   1380

cattcccaca tcgcccggct accagccaag ctccaagttg tcctgcccca ctaagaggag   1440

ccccggggtg gaacaagatc ctgtctgccc cggctctccc ccttacatgc tgtggaatga   1500

ggacatagga ccctgcacag ctgcaagtgg gctttcgatg tgaaaccttt caccagccac   1560

tcactatgct actcctggtg gggagggatg gggagtcgcc ctcccccgga gcccacagag   1620

ccctcccccg tcacgtcacc tgtgccttac tcctgcccac caccttttca gtgcagggtc   1680

agtcttaaga actccacatc tgctgctgct ccctggtgtc caagtttcct tgcagagtgt   1740

gtgaagaatt atttattttt gccaaagcag atctaataaa agccacagct cagcttctg    1799


