                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  COMPOSITIONS AND METHODS OF USE FOR THERAPEUTIC ANTIBODIES

<130>  53543A

<160>  41    

<170>  PatentIn version 3.3

<210>  1
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  1

Gly Phe Ser Leu Ser Thr Ser Thr Met Gly Val Ser 
1               5                   10          


<210>  2
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  2

Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Ser 
1               5                   10          


<210>  3
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  3

Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser 
1               5                   10  


<210>  4
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  4

Gly Phe Ser Leu Ser Thr Arg Gly Val Gly Val Ser 
1               5                   10          


<210>  5
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  5

Trp Ile Tyr Trp Asp Asp Asp Lys Asp Tyr Ser Thr Ser Leu Lys Ser 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  6

Leu Ile Asp Trp Thr Asp Asp Lys Tyr Tyr Ser Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210>  7
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  7

Tyr Ile Glu Pro Lys Leu Phe Trp Tyr Ala Thr Phe Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  8
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  8

Leu Ile Tyr Trp Asp Glu Asp Lys Tyr Tyr Ser Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210>  9
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  9

Ala Asn Pro Asp Leu Gly Tyr Phe Asp Tyr 
1               5                   10  


<210>  10
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  10

Thr Val Gly Lys Gly Leu Tyr Arg Val Asp Asn 
1               5                   10      


<210>  11
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  11

Asn Asp Phe Met Glu Pro Ala Tyr Phe Ala Leu 
1               5                   10      


<210>  12
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  12

Tyr Gln Ser Gly Tyr Tyr Tyr Asn Asn Asp Gly Trp Gly Val Asp Ile 
1               5                   10                  15      


<210>  13
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  13

Thr Gly Thr Ser Ser Asp Leu Gly Glu Ser Asn Tyr Val Ser 
1               5                   10                  


<210>  14
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  14

Ser Gly Asp Asn Leu Gly Ser Lys Phe Ala Tyr 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  15

Ser Gly Asp Asn Leu Gly Ser Tyr Tyr Ala Tyr 
1               5                   10      


<210>  16
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  16

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Asn 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  17

Asp Val Asn Lys Arg Pro Ser 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  18

Asp Asp Ser Lys Arg Pro Ser 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  19

Asp Asp Ser Glu Arg Pro Ser 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  20

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  21
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  21

Gly Ser Tyr Asp Glu Glu Asp Asn 
1               5               


<210>  22
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  22

Gln Ser Trp Asp Ser Ser Ser Gly Asn Asp 
1               5                   10  


<210>  23
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  23

Ser Ser Tyr Thr Tyr Ser Lys Asn Asn 
1               5                   


<210>  24
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  24

Gln Gln Tyr Tyr Ala Phe Pro His 
1               5               


<210>  25
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  25

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Glu Ser 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Met Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Asp Glu Glu 
                85                  90                  95      


Asp Asn Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110     


<210>  26
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  26

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Leu Gly Ser Lys Phe Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Ser Ser Ser Gly Asn 
                85                  90                  95      


Asp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110 


<210>  27
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  27

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Leu Gly Ser Tyr Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Gly Val Ile Tyr 
        35                  40                  45              


Asp Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Tyr Ser Lys Asn Asn 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 


<210>  28
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ala Phe Pro His 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  29
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  29

Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Thr Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Trp Ile Tyr Trp Asp Asp Asp Lys Asp Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asn Pro Asp Leu Gly Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  30

Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Asp Trp Thr Asp Asp Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Val Gly Lys Gly Leu Tyr Arg Val Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  31
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Glu Pro Lys Leu Phe Trp Tyr Ala Thr Phe Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asn Asp Phe Met Glu Pro Ala Tyr Phe Ala Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  32
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  32

Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Arg 
            20                  25                  30          


Gly Val Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Glu Asp Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Tyr Gln Ser Gly Tyr Tyr Tyr Asn Asn Asp Gly Trp Gly 
            100                 105                 110         


Val Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  33
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  33
gacatcgccc tgacccagcc cgccagcgtg tctggcagcc ctggccagag catcaccatc     60

agctgcaccg gcaccagcag cgacctgggc gagagcaact acgtgtcctg gtatcagcag    120

caccccggca aggcccccaa ggtgatgatc tacgacgtga acaagcggcc cagcggcgtg    180

tccaaccggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggactg    240

caggccgagg acgaggccga ctactactgc ggcagctacg acgaagagga caacgtgttt    300

ggcggcggaa caaagcttac cgtcctaggt cag                                 333


<210>  34
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  34
gacatcgagc tgacccagcc ccccagcgtg tctgtggccc ctggccagac cgcccggatc     60

agctgcagcg gcgacaacct gggcagcaag ttcgcctact ggtatcagca gaagcccggc    120

caggcccccg tgctggtgat ctacgacgac agcaagcggc ccagcggcat ccccgagcgg    180

ttcagcggca gcaacagcgg caacaccgcc accctgacca tcagcggcac ccaggccgag    240

gacgaggccg actactactg ccagagctgg gacagcagct ccggcaacga cgtgtttggc    300

ggcggaacaa agcttaccgt cctaggtcag                                     330


<210>  35
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  35
gacatcgagc tgacccagcc ccccagcgtg tctgtggccc ctggccagac cgcccggatc     60

agctgcagcg gcgacaacct gggcagctac tacgcctact ggtatcagca gaagcccggc    120

caggcccctg tgggcgtgat ctacgacgac agcgagcggc ccagcggcat ccccgagcgg    180

ttcagcggca gcaacagcgg caacaccgcc accctgacca tcagcggcac ccaggccgag    240

gacgaggccg actactactg cagcagctac acctacagca agaacaacgt gtttggcggc    300

ggaacaaagc ttaccgtcct aggtcag                                        327


<210>  36
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  36
gatatccaga tgacccagag cccgtctagc ctgagcgcga gcgtgggtga tcgtgtgacc     60

attacctgca gagcgagcca gtctatttct tcttggctga attggtacca gcagaaacca    120

ggtaaagcac cgaaactatt aatttatgct gcttcttctt tgcaaagcgg ggtcccgtcc    180

cgttttagcg gctctggatc cggcactgat tttaccctga ccattagcag cctgcaacct    240

gaagactttg cgacctatta ttgccagcag tattatgctt ttcctcatac ctttggccag    300

ggtacgaaag ttgaaattaa acgtacg                                        327


<210>  37
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  37
caggtgcagc tgaaagagag cggccctgcc ctggtcaagc ccacccagac cctgaccctg     60

acatgcacct tcagcggctt cagcctgagc accagcacca tgggcgtgtc ctggatccgg    120

cagccccctg gcaaggccct ggaatggctg gcctggatct actgggacga cgacaaggac    180

tacagcacca gcctgaagag ccggctgacc atcagcaagg acaccagcaa gaaccaggtg    240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cctactactg cgccagagcc    300

aaccccgacc tgggctactt cgactactgg ggccagggca ccctggtcac cgtctcctca    360


<210>  38
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  38
caggtgcagc tgaaagagag cggccctgcc ctggtcaagc ccacccagac cctgaccctg     60

acatgcacct tcagcggctt cagcctgagc accagcggca tgggcgtgtc ctggatccgg    120

cagccccctg gcaaggccct ggaatggctg gccctgatcg actggaccga cgacaagtac    180

tacagcacca gcctgaaaac ccggctgacc atcagcaagg acaccagcaa gaaccaggtg    240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cctactactg cgcccggaca    300

gtgggcaagg gcctgtaccg ggtggacaac tggggccagg gcaccctggt caccgtctcc    360

tca                                                                  363


<210>  39
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  39
caggtgcagc tggtcgagag cggcggaggg ctggtgcagc ctggcggcag cctgagactg     60

agctgcgccg ccagcggctt caccttcagc agctacggca tgagctgggt gcggcaggcc    120

cctggcaagg gcctggaatg ggtgtcctac atcgagccca agctgttctg gtacgccacc    180

ttctacgccg cctccgtgaa gggccggttc accatcagcc gggacaacag caagaacacc    240

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtacta ctgcgcccgg    300

aacgacttca tggaacccgc ctacttcgcc ctgtggggcc agggcaccct ggtcaccgtc    360

tcctca                                                               366


<210>  40
<211>  378
<212>  DNA
<213>  Artificial

<220>
<223>  artificial antibody fragment

<400>  40
caggtgcaat tgaaagaaag cggcccggcc ctggtgaaac cgacccaaac cctgaccctg     60

acctgtacct tttccggatt tagcctgtct actcgtggtg ttggtgtgtc ttggattcgc    120

cagccgcctg ggaaagccct cgagtggctg gctcttatct attgggatga ggataagtat    180

tatagcacca gcctgaaaac gcgtctgacc attagcaaag atacttcgaa aaatcaggtg    240

gtgctgacta tgaccaacat ggacccggtg gatacggcca cctattattg cgcgcgttat    300

cagtctggtt attattataa taatgatggt tggggtgttg atatttgggg ccaaggcacc    360

ctggtgacgg ttagctca                                                  378


<210>  41
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Glu Pro Val Ala Leu Asn Ile Ser Val Gly Thr Asn 
            340                 345                 350         


Gly Thr Thr Met Tyr Trp Pro Ala Arg Ala Gln Ser Met Thr Tyr Cys 
        355                 360                 365             


Ile Glu Trp Gln Pro Val Gly Gln Asp Gly Gly Leu Ala Thr Cys Ser 
    370                 375                 380                 


Leu Thr Ala Pro Gln Asp Pro Asp Pro Ala Gly Met Ala Thr Tyr Ser 
385                 390                 395                 400 


Trp Ser Arg Glu Ser Gly Ala Met Gly Gln Glu Lys Cys Tyr Tyr Ile 
                405                 410                 415     


Thr Ile Phe Ala Ser Ala His Pro Glu Lys Leu Thr Leu Trp Ser Thr 
            420                 425                 430         


Val Leu Ser Thr Tyr His Phe Gly Gly Asn Ala Ser Ala Ala Gly Thr 
        435                 440                 445             


Pro His His Val Ser Val Lys Asn His Ser Leu Asp Ser Val Ser Val 
    450                 455                 460                 


Asp Trp Ala Pro Ser Leu Leu Ser Thr Cys Pro Gly Val Leu Lys Glu 
465                 470                 475                 480 


Tyr Val Val Arg Cys Arg Asp Glu Asp Ser Lys Gln Val Ser Glu His 
                485                 490                 495     


Pro Val Gln Pro Thr Glu Thr Gln Val Thr Leu Ser Gly Leu Arg Ala 
            500                 505                 510         


Gly Val Ala Tyr Thr Val Gln Val Arg Ala Asp Thr Ala Trp Leu Arg 
        515                 520                 525             


Gly Val Trp Ser Gln Pro Gln Arg Phe Ser Ile Glu Val Gln Val Ser 
    530                 535                 540                 


Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu 
545                 550                 555                 560 


Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg Ala Ala Arg His 
                565                 570                 575     


Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe 
            580                 585                 590         


Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln 
        595                 600                 605             


Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu Met Ser Trp Asp 
    610                 615                 620                 


Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro Glu Gly 
625                 630                 635                 640 


Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp Gly Asp 
                645                 650                 655     


Arg Cys Lys Ala Lys Met 
            660         


