SEQUENCE LISTING

<110>  ZymoGenetics, Inc.
        Pan, Qi
       Birks, Carl W.
       Sivakumar, Pallavur V.
 
<120>  COMPOSITIONS AND METHODS FOR USING MULTISPECIFIC-BINDING PROTEINS
        COMPRISING AN ANTIBODY-RECEPTOR COMBINATION

<130>  08-18PC

<160>  89    

<170>  PatentIn version 3.5

<210>  1
<211>  1863
<212>  DNA
<213>  Artificial

<220>
<223>  pZMP31solFGFR3IIIc(23_375)(S249W)Fc5


<220>
<221>  CDS
<222>  (1)..(1863)

<400>  1
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga gag tcc ttg ggg acg gag cag cgc gtc gtg ggg cga gcg        144
Phe Arg Arg Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala           
        35                  40                  45                        

gca gaa gtc ccg ggc cca gag ccc ggc cag cag gag cag ttg gtc ttc        192
Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe           
    50                  55                  60                            

ggc agc ggg gat gct gtg gag ctg agc tgt ccc ccg ccc ggg ggt ggt        240
Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly           
65                  70                  75                  80            

ccc atg ggg ccc act gtc tgg gtc aag gat ggc aca ggg ctg gtg ccc        288
Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro           
                85                  90                  95                

tcg gag cgt gtc ctg gtg ggg ccc cag cgg ctg cag gtg ctg aat gcc        336
Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala           
            100                 105                 110                   

tcc cac gag gac tcc ggg gcc tac agc tgc cgg cag cgg ctc acg cag        384
Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln           
        115                 120                 125                       

cgc gta ctg tgc cac ttc agt gtg cgg gtg aca gac gct cca tcc tcg        432
Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser           
    130                 135                 140                           

gga gat gac gaa gac ggg gag gac gag gct gag gac aca ggt gtg gac        480
Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp           
145                 150                 155                 160           

aca ggg gcc cct tac tgg aca cgg ccc gag cgg atg gac aag aag ctg        528
Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu           
                165                 170                 175               

ctg gcc gtg ccg gcc gcc aac acc gtc cgc ttc cgc tgc cca gcc gct        576
Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala           
            180                 185                 190                   

ggc aac ccc act ccc tcc atc tcc tgg ctg aag aac ggc agg gag ttc        624
Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe           
        195                 200                 205                       

cgc ggc gag cac cgc att gga ggc atc aag ctg cgg cat cag cag tgg        672
Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp           
    210                 215                 220                           

agc ctg gtc atg gaa agc gtg gtg ccc tcg gac cgc ggc aac tac acc        720
Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr           
225                 230                 235                 240           

tgc gtc gtg gag aac aag ttt ggc agc atc cgg cag acg tac acg ctg        768
Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu           
                245                 250                 255               

gac gtg ctg gag cgc tgg ccg cac cgg ccc atc ctg cag gcg ggg ctg        816
Asp Val Leu Glu Arg Trp Pro His Arg Pro Ile Leu Gln Ala Gly Leu           
            260                 265                 270                   

ccg gcc aac cag acg gcg gtg ctg ggc agc gac gtg gag ttc cac tgc        864
Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys           
        275                 280                 285                       

aag gtg tac agt gac gca cag ccc cac atc cag tgg ctc aag cac gtg        912
Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val           
    290                 295                 300                           

gag gtg aat ggc agc aag gtg ggc ccg gac ggc aca ccc tac gtt acc        960
Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr           
305                 310                 315                 320           

gtg ctc aag acg gcg ggc gct aac acc acc gac aag gag cta gag gtt       1008
Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val           
                325                 330                 335               

ctc tcc ttg cac aac gtc acc ttt gag gac gcc ggg gag tac acc tgc       1056
Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys           
            340                 345                 350                   

ctg gcg ggc aat tct att ggg ttt tct cat cac tct gcg tgg ctg gtg       1104
Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val           
        355                 360                 365                       

gtg ctg cca gcc gag gag gag ctg gtg gag gct gac gag gcg ggc agt       1152
Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser           
    370                 375                 380                           

gtg tat gca ggc gag ccc aaa tct tca gac aaa act cac aca tgc cca       1200
Val Tyr Ala Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro           
385                 390                 395                 400           

ccg tgc cca gca cct gaa gcc gag ggg gca ccg tca gtc ttc ctc ttc       1248
Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe           
                405                 410                 415               

ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc       1296
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val           
            420                 425                 430                   

aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc       1344
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe           
        435                 440                 445                       

aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg       1392
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro           
    450                 455                 460                           

cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc       1440
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr           
465                 470                 475                 480           

gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc       1488
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val           
                485                 490                 495               

tcc aac aaa gcc ctc cca tcc tcc atc gag aaa acc atc tcc aaa gcc       1536
Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala           
            500                 505                 510                   

aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg       1584
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg           
        515                 520                 525                       

gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc       1632
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly           
    530                 535                 540                           

ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg       1680
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro           
545                 550                 555                 560           

gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc       1728
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser           
                565                 570                 575               

ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag       1776
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln           
            580                 585                 590                   

ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac       1824
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His           
        595                 600                 605                       

tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa taa                   1863
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                           
    610                 615                 620                           


<210>  2
<211>  620
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  2

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala 
        35                  40                  45              


Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe 
    50                  55                  60                  


Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly 
65                  70                  75                  80  


Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro 
                85                  90                  95      


Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala 
            100                 105                 110         


Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln 
        115                 120                 125             


Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser 
    130                 135                 140                 


Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp 
145                 150                 155                 160 


Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu 
                165                 170                 175     


Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala 
            180                 185                 190         


Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe 
        195                 200                 205             


Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp 
    210                 215                 220                 


Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr 
225                 230                 235                 240 


Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu 
                245                 250                 255     


Asp Val Leu Glu Arg Trp Pro His Arg Pro Ile Leu Gln Ala Gly Leu 
            260                 265                 270         


Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys 
        275                 280                 285             


Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val 
    290                 295                 300                 


Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr 
305                 310                 315                 320 


Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val 
                325                 330                 335     


Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys 
            340                 345                 350         


Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val 
        355                 360                 365             


Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser 
    370                 375                 380                 


Val Tyr Ala Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
385                 390                 395                 400 


Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 
                405                 410                 415     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            420                 425                 430         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        435                 440                 445             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    450                 455                 460                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
465                 470                 475                 480 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                485                 490                 495     


Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            500                 505                 510         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        515                 520                 525             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    530                 535                 540                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
545                 550                 555                 560 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                565                 570                 575     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            580                 585                 590         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        595                 600                 605             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620 


<210>  3
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  zc62552

<400>  3
caggaaatcc atgccgagtt gagacgcttc cgtagagagt ccttggggac ggagcagcgc       60


<210>  4
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  zc62557

<400>  4
cgcctgcagg atgggccggt gcggccagcg ctccagcacg tccagcgtgt                  50


<210>  5
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  zc62556

<400>  5
tacacgctgg acgtgctgga gcgctggccg caccggccca tcctgcaggc g                51


<210>  6
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  zc62553

<400>  6
tgggcatgtg tgagttttgt ctgaagattt gggctcgcct gcatacacac tgcccgcctc       60


<210>  7
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  zc62554

<400>  7
gtggaggctg acgaggcggg cagtgtgtat gcaggcgagc ccaaatcttc agacaaaact       60


<210>  8
<211>  61
<212>  DNA
<213>  Artificial

<220>
<223>  zc62555

<400>  8
caaccccaga gctgttttaa ggcgcgcctc tagattattt acccggagac agggagaggc       60

t                                                                       61


<210>  9
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  pZMP31solFGFR3IIIc(143_375)(S249W)Fc5


<220>
<221>  CDS
<222>  (1)..(1503)

<400>  9
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga gac aca ggt gtg gac aca ggg gcc cct tac tgg aca cgg        144
Phe Arg Arg Asp Thr Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg           
        35                  40                  45                        

ccc gag cgg atg gac aag aag ctg ctg gcc gtg ccg gcc gcc aac acc        192
Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr           
    50                  55                  60                            

gtc cgc ttc cgc tgc cca gcc gct ggc aac ccc act ccc tcc atc tcc        240
Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser           
65                  70                  75                  80            

tgg ctg aag aac ggc agg gag ttc cgc ggc gag cac cgc att gga ggc        288
Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly           
                85                  90                  95                

atc aag ctg cgg cat cag cag tgg agc ctg gtc atg gaa agc gtg gtg        336
Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu Ser Val Val           
            100                 105                 110                   

ccc tcg gac cgc ggc aac tac acc tgc gtc gtg gag aac aag ttt ggc        384
Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly           
        115                 120                 125                       

agc atc cgg cag acg tac acg ctg gac gtg ctg gag cgc tgg ccg cac        432
Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu Arg Trp Pro His           
    130                 135                 140                           

cgg ccc atc ctg cag gcg ggg ctg ccg gcc aac cag acg gcg gtg ctg        480
Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu           
145                 150                 155                 160           

ggc agc gac gtg gag ttc cac tgc aag gtg tac agt gac gca cag ccc        528
Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro           
                165                 170                 175               

cac atc cag tgg ctc aag cac gtg gag gtg aat ggc agc aag gtg ggc        576
His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly           
            180                 185                 190                   

ccg gac ggc aca ccc tac gtt acc gtg ctc aag acg gcg ggc gct aac        624
Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn           
        195                 200                 205                       

acc acc gac aag gag cta gag gtt ctc tcc ttg cac aac gtc acc ttt        672
Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His Asn Val Thr Phe           
    210                 215                 220                           

gag gac gcc ggg gag tac acc tgc ctg gcg ggc aat tct att ggg ttt        720
Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe           
225                 230                 235                 240           

tct cat cac tct gcg tgg ctg gtg gtg ctg cca gcc gag gag gag ctg        768
Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu           
                245                 250                 255               

gtg gag gct gac gag gcg ggc agt gtg tat gca ggc gag ccc aaa tct        816
Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly Glu Pro Lys Ser           
            260                 265                 270                   

tca gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa gcc gag        864
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu           
        275                 280                 285                       

ggg gca ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc        912
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu           
    290                 295                 300                           

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc        960
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser           
305                 310                 315                 320           

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag       1008
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu           
                325                 330                 335               

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg       1056
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr           
            340                 345                 350                   

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat       1104
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn           
        355                 360                 365                       

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca tcc tcc       1152
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser           
    370                 375                 380                           

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag       1200
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln           
385                 390                 395                 400           

gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc       1248
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val           
                405                 410                 415               

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg       1296
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val           
            420                 425                 430                   

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct       1344
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro           
        435                 440                 445                       

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc       1392
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr           
    450                 455                 460                           

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg       1440
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val           
465                 470                 475                 480           

atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg       1488
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu           
                485                 490                 495               

tct ccg ggt aaa taa                                                   1503
Ser Pro Gly Lys                                                           
            500                                                           


<210>  10
<211>  500
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  10

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Asp Thr Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg 
        35                  40                  45              


Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr 
    50                  55                  60                  


Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser 
65                  70                  75                  80  


Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly 
                85                  90                  95      


Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu Ser Val Val 
            100                 105                 110         


Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly 
        115                 120                 125             


Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu Arg Trp Pro His 
    130                 135                 140                 


Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu 
145                 150                 155                 160 


Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro 
                165                 170                 175     


His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly 
            180                 185                 190         


Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn 
        195                 200                 205             


Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His Asn Val Thr Phe 
    210                 215                 220                 


Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe 
225                 230                 235                 240 


Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu 
                245                 250                 255     


Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys 
            500 


<210>  11
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  zc62560

<400>  11
caggaaatcc atgccgagtt gagacgcttc cgtagagaca caggtgtgga cacaggggcc       60


<210>  12
<211>  1863
<212>  DNA
<213>  Artificial

<220>
<223>  pZMP31solFGFR3IIIc(23_375)Fc5


<220>
<221>  CDS
<222>  (1)..(1863)

<400>  12
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga gag tcc ttg ggg acg gag cag cgc gtc gtg ggg cga gcg        144
Phe Arg Arg Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala           
        35                  40                  45                        

gca gaa gtc ccg ggc cca gag ccc ggc cag cag gag cag ttg gtc ttc        192
Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe           
    50                  55                  60                            

ggc agc ggg gat gct gtg gag ctg agc tgt ccc ccg ccc ggg ggt ggt        240
Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly           
65                  70                  75                  80            

ccc atg ggg ccc act gtc tgg gtc aag gat ggc aca ggg ctg gtg ccc        288
Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro           
                85                  90                  95                

tcg gag cgt gtc ctg gtg ggg ccc cag cgg ctg cag gtg ctg aat gcc        336
Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala           
            100                 105                 110                   

tcc cac gag gac tcc ggg gcc tac agc tgc cgg cag cgg ctc acg cag        384
Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln           
        115                 120                 125                       

cgc gta ctg tgc cac ttc agt gtg cgg gtg aca gac gct cca tcc tcg        432
Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser           
    130                 135                 140                           

gga gat gac gaa gac ggg gag gac gag gct gag gac aca ggt gtg gac        480
Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp           
145                 150                 155                 160           

aca ggg gcc cct tac tgg aca cgg ccc gag cgg atg gac aag aag ctg        528
Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu           
                165                 170                 175               

ctg gcc gtg ccg gcc gcc aac acc gtc cgc ttc cgc tgc cca gcc gct        576
Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala           
            180                 185                 190                   

ggc aac ccc act ccc tcc atc tcc tgg ctg aag aac ggc agg gag ttc        624
Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe           
        195                 200                 205                       

cgc ggc gag cac cgc att gga ggc atc aag ctg cgg cat cag cag tgg        672
Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp           
    210                 215                 220                           

agc ctg gtc atg gaa agc gtg gtg ccc tcg gac cgc ggc aac tac acc        720
Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr           
225                 230                 235                 240           

tgc gtc gtg gag aac aag ttt ggc agc atc cgg cag acg tac acg ctg        768
Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu           
                245                 250                 255               

gac gtg ctg gag cgc tcc ccg cac cgg ccc atc ctg cag gcg ggg ctg        816
Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu           
            260                 265                 270                   

ccg gcc aac cag acg gcg gtg ctg ggc agc gac gtg gag ttc cac tgc        864
Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys           
        275                 280                 285                       

aag gtg tac agt gac gca cag ccc cac atc cag tgg ctc aag cac gtg        912
Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val           
    290                 295                 300                           

gag gtg aat ggc agc aag gtg ggc ccg gac ggc aca ccc tac gtt acc        960
Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr           
305                 310                 315                 320           

gtg ctc aag acg gcg ggc gct aac acc acc gac aag gag cta gag gtt       1008
Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val           
                325                 330                 335               

ctc tcc ttg cac aac gtc acc ttt gag gac gcc ggg gag tac acc tgc       1056
Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys           
            340                 345                 350                   

ctg gcg ggc aat tct att ggg ttt tct cat cac tct gcg tgg ctg gtg       1104
Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val           
        355                 360                 365                       

gtg ctg cca gcc gag gag gag ctg gtg gag gct gac gag gcg ggc agt       1152
Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser           
    370                 375                 380                           

gtg tat gca ggc gag ccc aaa tct tca gac aaa act cac aca tgc cca       1200
Val Tyr Ala Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro           
385                 390                 395                 400           

ccg tgc cca gca cct gaa gcc gag ggg gca ccg tca gtc ttc ctc ttc       1248
Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe           
                405                 410                 415               

ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc       1296
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val           
            420                 425                 430                   

aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc       1344
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe           
        435                 440                 445                       

aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg       1392
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro           
    450                 455                 460                           

cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc       1440
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr           
465                 470                 475                 480           

gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc       1488
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val           
                485                 490                 495               

tcc aac aaa gcc ctc cca tcc tcc atc gag aaa acc atc tcc aaa gcc       1536
Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala           
            500                 505                 510                   

aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg       1584
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg           
        515                 520                 525                       

gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc       1632
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly           
    530                 535                 540                           

ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg       1680
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro           
545                 550                 555                 560           

gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc       1728
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser           
                565                 570                 575               

ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag       1776
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln           
            580                 585                 590                   

ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac       1824
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His           
        595                 600                 605                       

tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa taa                   1863
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                           
    610                 615                 620                           


<210>  13
<211>  620
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  13

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala 
        35                  40                  45              


Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe 
    50                  55                  60                  


Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly 
65                  70                  75                  80  


Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro 
                85                  90                  95      


Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala 
            100                 105                 110         


Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln 
        115                 120                 125             


Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser 
    130                 135                 140                 


Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp 
145                 150                 155                 160 


Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu 
                165                 170                 175     


Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala 
            180                 185                 190         


Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe 
        195                 200                 205             


Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp 
    210                 215                 220                 


Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr 
225                 230                 235                 240 


Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu 
                245                 250                 255     


Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu 
            260                 265                 270         


Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys 
        275                 280                 285             


Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val 
    290                 295                 300                 


Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr 
305                 310                 315                 320 


Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val 
                325                 330                 335     


Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys 
            340                 345                 350         


Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val 
        355                 360                 365             


Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser 
    370                 375                 380                 


Val Tyr Ala Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
385                 390                 395                 400 


Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 
                405                 410                 415     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            420                 425                 430         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        435                 440                 445             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    450                 455                 460                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
465                 470                 475                 480 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                485                 490                 495     


Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            500                 505                 510         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        515                 520                 525             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    530                 535                 540                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
545                 550                 555                 560 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                565                 570                 575     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            580                 585                 590         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        595                 600                 605             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620 


<210>  14
<211>  1863
<212>  DNA
<213>  Artificial

<220>
<223>  pZMP31solFGFR3IIIc(23_375)(P250R)Fc5


<220>
<221>  CDS
<222>  (1)..(1863)

<400>  14
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga gag tcc ttg ggg acg gag cag cgc gtc gtg ggg cga gcg        144
Phe Arg Arg Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala           
        35                  40                  45                        

gca gaa gtc ccg ggc cca gag ccc ggc cag cag gag cag ttg gtc ttc        192
Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe           
    50                  55                  60                            

ggc agc ggg gat gct gtg gag ctg agc tgt ccc ccg ccc ggg ggt ggt        240
Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly           
65                  70                  75                  80            

ccc atg ggg ccc act gtc tgg gtc aag gat ggc aca ggg ctg gtg ccc        288
Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro           
                85                  90                  95                

tcg gag cgt gtc ctg gtg ggg ccc cag cgg ctg cag gtg ctg aat gcc        336
Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala           
            100                 105                 110                   

tcc cac gag gac tcc ggg gcc tac agc tgc cgg cag cgg ctc acg cag        384
Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln           
        115                 120                 125                       

cgc gta ctg tgc cac ttc agt gtg cgg gtg aca gac gct cca tcc tcg        432
Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser           
    130                 135                 140                           

gga gat gac gaa gac ggg gag gac gag gct gag gac aca ggt gtg gac        480
Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp           
145                 150                 155                 160           

aca ggg gcc cct tac tgg aca cgg ccc gag cgg atg gac aag aag ctg        528
Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu           
                165                 170                 175               

ctg gcc gtg ccg gcc gcc aac acc gtc cgc ttc cgc tgc cca gcc gct        576
Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala           
            180                 185                 190                   

ggc aac ccc act ccc tcc atc tcc tgg ctg aag aac ggc agg gag ttc        624
Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe           
        195                 200                 205                       

cgc ggc gag cac cgc att gga ggc atc aag ctg cgg cat cag cag tgg        672
Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp           
    210                 215                 220                           

agc ctg gtc atg gaa agc gtg gtg ccc tcg gac cgc ggc aac tac acc        720
Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr           
225                 230                 235                 240           

tgc gtc gtg gag aac aag ttt ggc agc atc cgg cag acg tac acg ctg        768
Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu           
                245                 250                 255               

gac gtg ctg gag cgc tcc cgg cac cgg ccc atc ctg cag gcg ggg ctg        816
Asp Val Leu Glu Arg Ser Arg His Arg Pro Ile Leu Gln Ala Gly Leu           
            260                 265                 270                   

ccg gcc aac cag acg gcg gtg ctg ggc agc gac gtg gag ttc cac tgc        864
Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys           
        275                 280                 285                       

aag gtg tac agt gac gca cag ccc cac atc cag tgg ctc aag cac gtg        912
Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val           
    290                 295                 300                           

gag gtg aat ggc agc aag gtg ggc ccg gac ggc aca ccc tac gtt acc        960
Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr           
305                 310                 315                 320           

gtg ctc aag acg gcg ggc gct aac acc acc gac aag gag cta gag gtt       1008
Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val           
                325                 330                 335               

ctc tcc ttg cac aac gtc acc ttt gag gac gcc ggg gag tac acc tgc       1056
Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys           
            340                 345                 350                   

ctg gcg ggc aat tct att ggg ttt tct cat cac tct gcg tgg ctg gtg       1104
Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val           
        355                 360                 365                       

gtg ctg cca gcc gag gag gag ctg gtg gag gct gac gag gcg ggc agt       1152
Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser           
    370                 375                 380                           

gtg tat gca ggc gag ccc aaa tct tca gac aaa act cac aca tgc cca       1200
Val Tyr Ala Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro           
385                 390                 395                 400           

ccg tgc cca gca cct gaa gcc gag ggg gca ccg tca gtc ttc ctc ttc       1248
Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe           
                405                 410                 415               

ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc       1296
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val           
            420                 425                 430                   

aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc       1344
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe           
        435                 440                 445                       

aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg       1392
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro           
    450                 455                 460                           

cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc       1440
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr           
465                 470                 475                 480           

gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc       1488
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val           
                485                 490                 495               

tcc aac aaa gcc ctc cca tcc tcc atc gag aaa acc atc tcc aaa gcc       1536
Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala           
            500                 505                 510                   

aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg       1584
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg           
        515                 520                 525                       

gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc       1632
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly           
    530                 535                 540                           

ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg       1680
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro           
545                 550                 555                 560           

gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc       1728
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser           
                565                 570                 575               

ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag       1776
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln           
            580                 585                 590                   

ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac       1824
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His           
        595                 600                 605                       

tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa taa                   1863
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                           
    610                 615                 620                           


<210>  15
<211>  620
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  15

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala 
        35                  40                  45              


Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe 
    50                  55                  60                  


Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly 
65                  70                  75                  80  


Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro 
                85                  90                  95      


Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala 
            100                 105                 110         


Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln 
        115                 120                 125             


Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser 
    130                 135                 140                 


Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp 
145                 150                 155                 160 


Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu 
                165                 170                 175     


Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala 
            180                 185                 190         


Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe 
        195                 200                 205             


Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp 
    210                 215                 220                 


Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr 
225                 230                 235                 240 


Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu 
                245                 250                 255     


Asp Val Leu Glu Arg Ser Arg His Arg Pro Ile Leu Gln Ala Gly Leu 
            260                 265                 270         


Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys 
        275                 280                 285             


Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val 
    290                 295                 300                 


Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr 
305                 310                 315                 320 


Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val 
                325                 330                 335     


Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys 
            340                 345                 350         


Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val 
        355                 360                 365             


Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser 
    370                 375                 380                 


Val Tyr Ala Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
385                 390                 395                 400 


Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 
                405                 410                 415     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            420                 425                 430         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        435                 440                 445             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    450                 455                 460                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
465                 470                 475                 480 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                485                 490                 495     


Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            500                 505                 510         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        515                 520                 525             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    530                 535                 540                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
545                 550                 555                 560 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                565                 570                 575     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            580                 585                 590         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        595                 600                 605             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620 


<210>  16
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  zc62558

<400>  16
ccccgcctgc aggatgggcc ggtgccggga gcgctccagc acgtccagcg t                51


<210>  17
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  zc62559

<400>  17
acgctggacg tgctggagcg ctcccggcac cggcccatcc tgcaggcggg g                51


<210>  18
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  pZMP31solFGFR3IIIc(143_375)Fc5


<220>
<221>  CDS
<222>  (1)..(1503)

<400>  18
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga gac aca ggt gtg gac aca ggg gcc cct tac tgg aca cgg        144
Phe Arg Arg Asp Thr Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg           
        35                  40                  45                        

ccc gag cgg atg gac aag aag ctg ctg gcc gtg ccg gcc gcc aac acc        192
Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr           
    50                  55                  60                            

gtc cgc ttc cgc tgc cca gcc gct ggc aac ccc act ccc tcc atc tcc        240
Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser           
65                  70                  75                  80            

tgg ctg aag aac ggc agg gag ttc cgc ggc gag cac cgc att gga ggc        288
Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly           
                85                  90                  95                

atc aag ctg cgg cat cag cag tgg agc ctg gtc atg gaa agc gtg gtg        336
Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu Ser Val Val           
            100                 105                 110                   

ccc tcg gac cgc ggc aac tac acc tgc gtc gtg gag aac aag ttt ggc        384
Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly           
        115                 120                 125                       

agc atc cgg cag acg tac acg ctg gac gtg ctg gag cgc tcc ccg cac        432
Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His           
    130                 135                 140                           

cgg ccc atc ctg cag gcg ggg ctg ccg gcc aac cag acg gcg gtg ctg        480
Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu           
145                 150                 155                 160           

ggc agc gac gtg gag ttc cac tgc aag gtg tac agt gac gca cag ccc        528
Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro           
                165                 170                 175               

cac atc cag tgg ctc aag cac gtg gag gtg aat ggc agc aag gtg ggc        576
His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly           
            180                 185                 190                   

ccg gac ggc aca ccc tac gtt acc gtg ctc aag acg gcg ggc gct aac        624
Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn           
        195                 200                 205                       

acc acc gac aag gag cta gag gtt ctc tcc ttg cac aac gtc acc ttt        672
Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His Asn Val Thr Phe           
    210                 215                 220                           

gag gac gcc ggg gag tac acc tgc ctg gcg ggc aat tct att ggg ttt        720
Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe           
225                 230                 235                 240           

tct cat cac tct gcg tgg ctg gtg gtg ctg cca gcc gag gag gag ctg        768
Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu           
                245                 250                 255               

gtg gag gct gac gag gcg ggc agt gtg tat gca ggc gag ccc aaa tct        816
Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly Glu Pro Lys Ser           
            260                 265                 270                   

tca gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa gcc gag        864
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu           
        275                 280                 285                       

ggg gca ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc        912
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu           
    290                 295                 300                           

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc        960
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser           
305                 310                 315                 320           

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag       1008
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu           
                325                 330                 335               

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg       1056
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr           
            340                 345                 350                   

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat       1104
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn           
        355                 360                 365                       

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca tcc tcc       1152
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser           
    370                 375                 380                           

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag       1200
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln           
385                 390                 395                 400           

gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc       1248
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val           
                405                 410                 415               

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg       1296
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val           
            420                 425                 430                   

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct       1344
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro           
        435                 440                 445                       

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc       1392
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr           
    450                 455                 460                           

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg       1440
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val           
465                 470                 475                 480           

atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg       1488
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu           
                485                 490                 495               

tct ccg ggt aaa taa                                                   1503
Ser Pro Gly Lys                                                           
            500                                                           


<210>  19
<211>  500
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  19

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Asp Thr Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg 
        35                  40                  45              


Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr 
    50                  55                  60                  


Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser 
65                  70                  75                  80  


Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly 
                85                  90                  95      


Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu Ser Val Val 
            100                 105                 110         


Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly 
        115                 120                 125             


Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His 
    130                 135                 140                 


Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu 
145                 150                 155                 160 


Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro 
                165                 170                 175     


His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly 
            180                 185                 190         


Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn 
        195                 200                 205             


Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His Asn Val Thr Phe 
    210                 215                 220                 


Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe 
225                 230                 235                 240 


Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu 
                245                 250                 255     


Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys 
            500 


<210>  20
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  zc62560

<400>  20
caggaaatcc atgccgagtt gagacgcttc cgtagagaca caggtgtgga cacaggggcc       60


<210>  21
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  pZMP31solFGFR3IIIc(143_375)(P250R)Fc5


<220>
<221>  CDS
<222>  (1)..(1503)

<400>  21
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga gac aca ggt gtg gac aca ggg gcc cct tac tgg aca cgg        144
Phe Arg Arg Asp Thr Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg           
        35                  40                  45                        

ccc gag cgg atg gac aag aag ctg ctg gcc gtg ccg gcc gcc aac acc        192
Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr           
    50                  55                  60                            

gtc cgc ttc cgc tgc cca gcc gct ggc aac ccc act ccc tcc atc tcc        240
Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser           
65                  70                  75                  80            

tgg ctg aag aac ggc agg gag ttc cgc ggc gag cac cgc att gga ggc        288
Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly           
                85                  90                  95                

atc aag ctg cgg cat cag cag tgg agc ctg gtc atg gaa agc gtg gtg        336
Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu Ser Val Val           
            100                 105                 110                   

ccc tcg gac cgc ggc aac tac acc tgc gtc gtg gag aac aag ttt ggc        384
Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly           
        115                 120                 125                       

agc atc cgg cag acg tac acg ctg gac gtg ctg gag cgc tcc cgg cac        432
Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu Arg Ser Arg His           
    130                 135                 140                           

cgg ccc atc ctg cag gcg ggg ctg ccg gcc aac cag acg gcg gtg ctg        480
Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu           
145                 150                 155                 160           

ggc agc gac gtg gag ttc cac tgc aag gtg tac agt gac gca cag ccc        528
Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro           
                165                 170                 175               

cac atc cag tgg ctc aag cac gtg gag gtg aat ggc agc aag gtg ggc        576
His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly           
            180                 185                 190                   

ccg gac ggc aca ccc tac gtt acc gtg ctc aag acg gcg ggc gct aac        624
Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn           
        195                 200                 205                       

acc acc gac aag gag cta gag gtt ctc tcc ttg cac aac gtc acc ttt        672
Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His Asn Val Thr Phe           
    210                 215                 220                           

gag gac gcc ggg gag tac acc tgc ctg gcg ggc aat tct att ggg ttt        720
Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe           
225                 230                 235                 240           

tct cat cac tct gcg tgg ctg gtg gtg ctg cca gcc gag gag gag ctg        768
Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu           
                245                 250                 255               

gtg gag gct gac gag gcg ggc agt gtg tat gca ggc gag ccc aaa tct        816
Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly Glu Pro Lys Ser           
            260                 265                 270                   

tca gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa gcc gag        864
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu           
        275                 280                 285                       

ggg gca ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc        912
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu           
    290                 295                 300                           

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc        960
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser           
305                 310                 315                 320           

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag       1008
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu           
                325                 330                 335               

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg       1056
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr           
            340                 345                 350                   

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat       1104
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn           
        355                 360                 365                       

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca tcc tcc       1152
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser           
    370                 375                 380                           

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag       1200
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln           
385                 390                 395                 400           

gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc       1248
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val           
                405                 410                 415               

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg       1296
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val           
            420                 425                 430                   

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct       1344
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro           
        435                 440                 445                       

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc       1392
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr           
    450                 455                 460                           

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg       1440
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val           
465                 470                 475                 480           

atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg       1488
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu           
                485                 490                 495               

tct ccg ggt aaa taa                                                   1503
Ser Pro Gly Lys                                                           
            500                                                           


<210>  22
<211>  500
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  22

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Asp Thr Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg 
        35                  40                  45              


Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr 
    50                  55                  60                  


Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser 
65                  70                  75                  80  


Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly 
                85                  90                  95      


Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu Ser Val Val 
            100                 105                 110         


Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly 
        115                 120                 125             


Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu Arg Ser Arg His 
    130                 135                 140                 


Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu 
145                 150                 155                 160 


Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro 
                165                 170                 175     


His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly 
            180                 185                 190         


Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn 
        195                 200                 205             


Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His Asn Val Thr Phe 
    210                 215                 220                 


Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe 
225                 230                 235                 240 


Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu 
                245                 250                 255     


Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys 
            500 


<210>  23
<211>  1872
<212>  DNA
<213>  Artificial

<220>
<223>  pZMP31solFGFR2alphaIIIc(22_377)Fc5


<220>
<221>  CDS
<222>  (1)..(1872)

<400>  23
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga cgg ccc tcc ttc agt tta gtt gag gat acc aca tta gag        144
Phe Arg Arg Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu           
        35                  40                  45                        

cca gaa gag cca cca acc aaa tac caa atc tct caa cca gaa gtg tac        192
Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr           
    50                  55                  60                            

gtg gct gca cca ggg gag tcg cta gag gtg cgc tgc ctg ttg aaa gat        240
Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp           
65                  70                  75                  80            

gcc gcc gtg atc agt tgg act aag gat ggg gtg cac ttg ggg ccc aac        288
Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn           
                85                  90                  95                

aat agg aca gtg ctt att ggg gag tac ttg cag ata aag ggc gcc acg        336
Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr           
            100                 105                 110                   

cct aga gac tcc ggc ctc tat gct tgt act gcc agt agg act gta gac        384
Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp           
        115                 120                 125                       

agt gaa act tgg tac ttc atg gtg aat gtc aca gat gcc atc tca tcc        432
Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser           
    130                 135                 140                           

gga gat gat gag gat gac acc gat ggt gcg gaa gat ttt gtc agt gag        480
Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu           
145                 150                 155                 160           

aac agt aac aac aag aga gca cca tac tgg acc aac aca gaa aag atg        528
Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met           
                165                 170                 175               

gaa aag cgg ctc cat gct gtg cct gcg gcc aac act gtc aag ttt cgc        576
Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg           
            180                 185                 190                   

tgc cca gcc ggg ggg aac cca atg cca acc atg cgg tgg ctg aaa aac        624
Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn           
        195                 200                 205                       

ggg aag gag ttt aag cag gag cat cgc att gga ggc tac aag gta cga        672
Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg           
    210                 215                 220                           

aac cag cac tgg agc ctc att atg gaa agt gtg gtc cca tct gac aag        720
Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys           
225                 230                 235                 240           

gga aat tat acc tgt gtg gtg gag aat gaa tac ggg tcc atc aat cac        768
Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His           
                245                 250                 255               

acg tac cac ctg gat gtt gtg gag cga tcg cct cac cgg ccc atc ctc        816
Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu           
            260                 265                 270                   

caa gcc gga ctg ccg gca aat gcc tcc aca gtg gtc gga gga gac gta        864
Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val           
        275                 280                 285                       

gag ttt gtc tgc aag gtt tac agt gat gcc cag ccc cac atc cag tgg        912
Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp           
    290                 295                 300                           

atc aag cac gtg gaa aag aac ggc agt aaa tac ggg ccc gac ggg ctg        960
Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu           
305                 310                 315                 320           

ccc tac ctc aag gtt ctc aag gcc gcc ggt gtt aac acc acg gac aaa       1008
Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys           
                325                 330                 335               

gag att gag gtt ctc tat att cgg aat gta act ttt gag gac gct ggg       1056
Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly           
            340                 345                 350                   

gaa tat acg tgc ttg gcg ggt aat tct att ggg ata tcc ttt cac tct       1104
Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser           
        355                 360                 365                       

gca tgg ttg aca gtt ctg cca gcg cct gga aga gaa aag gag att aca       1152
Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr           
    370                 375                 380                           

gct tcc cca gac tac ctg gag gag ccc aaa tct tca gac aaa act cac       1200
Ala Ser Pro Asp Tyr Leu Glu Glu Pro Lys Ser Ser Asp Lys Thr His           
385                 390                 395                 400           

aca tgc cca ccg tgc cca gca cct gaa gcc gag ggg gca ccg tca gtc       1248
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val           
                405                 410                 415               

ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc       1296
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr           
            420                 425                 430                   

cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag       1344
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu           
        435                 440                 445                       

gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag       1392
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys           
    450                 455                 460                           

aca aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc       1440
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser           
465                 470                 475                 480           

gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag       1488
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys           
                485                 490                 495               

tgc aag gtc tcc aac aaa gcc ctc cca tcc tcc atc gag aaa acc atc       1536
Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile           
            500                 505                 510                   

tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc       1584
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro           
        515                 520                 525                       

cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg       1632
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu           
    530                 535                 540                           

gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat       1680
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn           
545                 550                 555                 560           

ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc       1728
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser           
                565                 570                 575               

gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg       1776
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg           
            580                 585                 590                   

tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg       1824
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu           
        595                 600                 605                       

cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa taa       1872
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys               
    610                 615                 620                           


<210>  24
<211>  623
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  24

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu 
        35                  40                  45              


Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr 
    50                  55                  60                  


Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp 
65                  70                  75                  80  


Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn 
                85                  90                  95      


Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr 
            100                 105                 110         


Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp 
        115                 120                 125             


Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser 
    130                 135                 140                 


Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu 
145                 150                 155                 160 


Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met 
                165                 170                 175     


Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg 
            180                 185                 190         


Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn 
        195                 200                 205             


Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg 
    210                 215                 220                 


Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys 
225                 230                 235                 240 


Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His 
                245                 250                 255     


Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu 
            260                 265                 270         


Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val 
        275                 280                 285             


Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp 
    290                 295                 300                 


Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu 
305                 310                 315                 320 


Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys 
                325                 330                 335     


Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly 
            340                 345                 350         


Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser 
        355                 360                 365             


Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr 
    370                 375                 380                 


Ala Ser Pro Asp Tyr Leu Glu Glu Pro Lys Ser Ser Asp Lys Thr His 
385                 390                 395                 400 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 
                405                 410                 415     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            420                 425                 430         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        435                 440                 445             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    450                 455                 460                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
465                 470                 475                 480 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                485                 490                 495     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile 
            500                 505                 510         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        515                 520                 525             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    530                 535                 540                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
545                 550                 555                 560 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                565                 570                 575     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            580                 585                 590         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        595                 600                 605             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620             


<210>  25
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  zc62932

<400>  25
caggaaatcc atgccgagtt gagacgcttc cgtagacggc cctccttcag tttagttgag       60


<210>  26
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  zc62933

<400>  26
tgggcatgtg tgagttttgt ctgaagattt gggctcctcc aggtagtctg gggaagctgt       60


<210>  27
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  zc62934

<400>  27
gaaaaggaga ttacagcttc cccagactac ctggaggagc ccaaatcttc agacaaaact       60


<210>  28
<211>  1872
<212>  DNA
<213>  Artificial

<220>
<223>  pZMP31solFGFR2alphaIIIc(22_377)(S252W)Fc5


<220>
<221>  CDS
<222>  (1)..(1872)

<400>  28
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga cgg ccc tcc ttc agt tta gtt gag gat acc aca tta gag        144
Phe Arg Arg Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu           
        35                  40                  45                        

cca gaa gag cca cca acc aaa tac caa atc tct caa cca gaa gtg tac        192
Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr           
    50                  55                  60                            

gtg gct gca cca ggg gag tcg cta gag gtg cgc tgc ctg ttg aaa gat        240
Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp           
65                  70                  75                  80            

gcc gcc gtg atc agt tgg act aag gat ggg gtg cac ttg ggg ccc aac        288
Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn           
                85                  90                  95                

aat agg aca gtg ctt att ggg gag tac ttg cag ata aag ggc gcc acg        336
Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr           
            100                 105                 110                   

cct aga gac tcc ggc ctc tat gct tgt act gcc agt agg act gta gac        384
Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp           
        115                 120                 125                       

agt gaa act tgg tac ttc atg gtg aat gtc aca gat gcc atc tca tcc        432
Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser           
    130                 135                 140                           

gga gat gat gag gat gac acc gat ggt gcg gaa gat ttt gtc agt gag        480
Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu           
145                 150                 155                 160           

aac agt aac aac aag aga gca cca tac tgg acc aac aca gaa aag atg        528
Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met           
                165                 170                 175               

gaa aag cgg ctc cat gct gtg cct gcg gcc aac act gtc aag ttt cgc        576
Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg           
            180                 185                 190                   

tgc cca gcc ggg ggg aac cca atg cca acc atg cgg tgg ctg aaa aac        624
Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn           
        195                 200                 205                       

ggg aag gag ttt aag cag gag cat cgc att gga ggc tac aag gta cga        672
Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg           
    210                 215                 220                           

aac cag cac tgg agc ctc att atg gaa agt gtg gtc cca tct gac aag        720
Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys           
225                 230                 235                 240           

gga aat tat acc tgt gtg gtg gag aat gaa tac ggg tcc atc aat cac        768
Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His           
                245                 250                 255               

acg tac cac ctg gat gtt gtg gag cga tgg cct cac cgg ccc atc ctc        816
Thr Tyr His Leu Asp Val Val Glu Arg Trp Pro His Arg Pro Ile Leu           
            260                 265                 270                   

caa gcc gga ctg ccg gca aat gcc tcc aca gtg gtc gga gga gac gta        864
Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val           
        275                 280                 285                       

gag ttt gtc tgc aag gtt tac agt gat gcc cag ccc cac atc cag tgg        912
Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp           
    290                 295                 300                           

atc aag cac gtg gaa aag aac ggc agt aaa tac ggg ccc gac ggg ctg        960
Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu           
305                 310                 315                 320           

ccc tac ctc aag gtt ctc aag gcc gcc ggt gtt aac acc acg gac aaa       1008
Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys           
                325                 330                 335               

gag att gag gtt ctc tat att cgg aat gta act ttt gag gac gct ggg       1056
Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly           
            340                 345                 350                   

gaa tat acg tgc ttg gcg ggt aat tct att ggg ata tcc ttt cac tct       1104
Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser           
        355                 360                 365                       

gca tgg ttg aca gtt ctg cca gcg cct gga aga gaa aag gag att aca       1152
Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr           
    370                 375                 380                           

gct tcc cca gac tac ctg gag gag ccc aaa tct tca gac aaa act cac       1200
Ala Ser Pro Asp Tyr Leu Glu Glu Pro Lys Ser Ser Asp Lys Thr His           
385                 390                 395                 400           

aca tgc cca ccg tgc cca gca cct gaa gcc gag ggg gca ccg tca gtc       1248
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val           
                405                 410                 415               

ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc       1296
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr           
            420                 425                 430                   

cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag       1344
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu           
        435                 440                 445                       

gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag       1392
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys           
    450                 455                 460                           

aca aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc       1440
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser           
465                 470                 475                 480           

gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag       1488
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys           
                485                 490                 495               

tgc aag gtc tcc aac aaa gcc ctc cca tcc tcc atc gag aaa acc atc       1536
Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile           
            500                 505                 510                   

tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc       1584
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro           
        515                 520                 525                       

cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg       1632
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu           
    530                 535                 540                           

gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat       1680
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn           
545                 550                 555                 560           

ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc       1728
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser           
                565                 570                 575               

gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg       1776
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg           
            580                 585                 590                   

tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg       1824
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu           
        595                 600                 605                       

cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa taa       1872
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys               
    610                 615                 620                           


<210>  29
<211>  623
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  29

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu 
        35                  40                  45              


Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr 
    50                  55                  60                  


Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp 
65                  70                  75                  80  


Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn 
                85                  90                  95      


Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr 
            100                 105                 110         


Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp 
        115                 120                 125             


Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser 
    130                 135                 140                 


Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu 
145                 150                 155                 160 


Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met 
                165                 170                 175     


Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg 
            180                 185                 190         


Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn 
        195                 200                 205             


Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg 
    210                 215                 220                 


Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys 
225                 230                 235                 240 


Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His 
                245                 250                 255     


Thr Tyr His Leu Asp Val Val Glu Arg Trp Pro His Arg Pro Ile Leu 
            260                 265                 270         


Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val 
        275                 280                 285             


Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp 
    290                 295                 300                 


Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu 
305                 310                 315                 320 


Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys 
                325                 330                 335     


Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly 
            340                 345                 350         


Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser 
        355                 360                 365             


Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr 
    370                 375                 380                 


Ala Ser Pro Asp Tyr Leu Glu Glu Pro Lys Ser Ser Asp Lys Thr His 
385                 390                 395                 400 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 
                405                 410                 415     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            420                 425                 430         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        435                 440                 445             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    450                 455                 460                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
465                 470                 475                 480 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                485                 490                 495     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile 
            500                 505                 510         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        515                 520                 525             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    530                 535                 540                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
545                 550                 555                 560 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                565                 570                 575     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            580                 585                 590         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        595                 600                 605             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620             


<210>  30
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  zc62937

<400>  30
ggcttggagg atgggccggt gaggccatcg ctccacaaca tccaggtggt a                51


<210>  31
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  zc62936

<400>  31
taccacctgg atgttgtgga gcgatggcct caccggccca tcctccaagc c                51


<210>  32
<211>  1872
<212>  DNA
<213>  Artificial

<220>
<223>  pZMP31solFGFR2alphaIIIc(22_377)(P253R)Fc5


<220>
<221>  CDS
<222>  (1)..(1872)

<400>  32
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga cgg ccc tcc ttc agt tta gtt gag gat acc aca tta gag        144
Phe Arg Arg Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu           
        35                  40                  45                        

cca gaa gag cca cca acc aaa tac caa atc tct caa cca gaa gtg tac        192
Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr           
    50                  55                  60                            

gtg gct gca cca ggg gag tcg cta gag gtg cgc tgc ctg ttg aaa gat        240
Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp           
65                  70                  75                  80            

gcc gcc gtg atc agt tgg act aag gat ggg gtg cac ttg ggg ccc aac        288
Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn           
                85                  90                  95                

aat agg aca gtg ctt att ggg gag tac ttg cag ata aag ggc gcc acg        336
Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr           
            100                 105                 110                   

cct aga gac tcc ggc ctc tat gct tgt act gcc agt agg act gta gac        384
Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp           
        115                 120                 125                       

agt gaa act tgg tac ttc atg gtg aat gtc aca gat gcc atc tca tcc        432
Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser           
    130                 135                 140                           

gga gat gat gag gat gac acc gat ggt gcg gaa gat ttt gtc agt gag        480
Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu           
145                 150                 155                 160           

aac agt aac aac aag aga gca cca tac tgg acc aac aca gaa aag atg        528
Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met           
                165                 170                 175               

gaa aag cgg ctc cat gct gtg cct gcg gcc aac act gtc aag ttt cgc        576
Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg           
            180                 185                 190                   

tgc cca gcc ggg ggg aac cca atg cca acc atg cgg tgg ctg aaa aac        624
Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn           
        195                 200                 205                       

ggg aag gag ttt aag cag gag cat cgc att gga ggc tac aag gta cga        672
Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg           
    210                 215                 220                           

aac cag cac tgg agc ctc att atg gaa agt gtg gtc cca tct gac aag        720
Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys           
225                 230                 235                 240           

gga aat tat acc tgt gtg gtg gag aat gaa tac ggg tcc atc aat cac        768
Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His           
                245                 250                 255               

acg tac cac ctg gat gtt gtg gag cga tcg cgt cac cgg ccc atc ctc        816
Thr Tyr His Leu Asp Val Val Glu Arg Ser Arg His Arg Pro Ile Leu           
            260                 265                 270                   

caa gcc gga ctg ccg gca aat gcc tcc aca gtg gtc gga gga gac gta        864
Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val           
        275                 280                 285                       

gag ttt gtc tgc aag gtt tac agt gat gcc cag ccc cac atc cag tgg        912
Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp           
    290                 295                 300                           

atc aag cac gtg gaa aag aac ggc agt aaa tac ggg ccc gac ggg ctg        960
Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu           
305                 310                 315                 320           

ccc tac ctc aag gtt ctc aag gcc gcc ggt gtt aac acc acg gac aaa       1008
Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys           
                325                 330                 335               

gag att gag gtt ctc tat att cgg aat gta act ttt gag gac gct ggg       1056
Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly           
            340                 345                 350                   

gaa tat acg tgc ttg gcg ggt aat tct att ggg ata tcc ttt cac tct       1104
Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser           
        355                 360                 365                       

gca tgg ttg aca gtt ctg cca gcg cct gga aga gaa aag gag att aca       1152
Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr           
    370                 375                 380                           

gct tcc cca gac tac ctg gag gag ccc aaa tct tca gac aaa act cac       1200
Ala Ser Pro Asp Tyr Leu Glu Glu Pro Lys Ser Ser Asp Lys Thr His           
385                 390                 395                 400           

aca tgc cca ccg tgc cca gca cct gaa gcc gag ggg gca ccg tca gtc       1248
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val           
                405                 410                 415               

ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc       1296
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr           
            420                 425                 430                   

cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag       1344
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu           
        435                 440                 445                       

gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag       1392
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys           
    450                 455                 460                           

aca aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc       1440
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser           
465                 470                 475                 480           

gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag       1488
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys           
                485                 490                 495               

tgc aag gtc tcc aac aaa gcc ctc cca tcc tcc atc gag aaa acc atc       1536
Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile           
            500                 505                 510                   

tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc       1584
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro           
        515                 520                 525                       

cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg       1632
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu           
    530                 535                 540                           

gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat       1680
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn           
545                 550                 555                 560           

ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc       1728
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser           
                565                 570                 575               

gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg       1776
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg           
            580                 585                 590                   

tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg       1824
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu           
        595                 600                 605                       

cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa taa       1872
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys               
    610                 615                 620                           


<210>  33
<211>  623
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  33

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu 
        35                  40                  45              


Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr 
    50                  55                  60                  


Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp 
65                  70                  75                  80  


Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn 
                85                  90                  95      


Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr 
            100                 105                 110         


Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp 
        115                 120                 125             


Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser 
    130                 135                 140                 


Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu 
145                 150                 155                 160 


Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met 
                165                 170                 175     


Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg 
            180                 185                 190         


Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn 
        195                 200                 205             


Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg 
    210                 215                 220                 


Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys 
225                 230                 235                 240 


Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His 
                245                 250                 255     


Thr Tyr His Leu Asp Val Val Glu Arg Ser Arg His Arg Pro Ile Leu 
            260                 265                 270         


Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val 
        275                 280                 285             


Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp 
    290                 295                 300                 


Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu 
305                 310                 315                 320 


Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys 
                325                 330                 335     


Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly 
            340                 345                 350         


Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser 
        355                 360                 365             


Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr 
    370                 375                 380                 


Ala Ser Pro Asp Tyr Leu Glu Glu Pro Lys Ser Ser Asp Lys Thr His 
385                 390                 395                 400 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 
                405                 410                 415     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            420                 425                 430         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        435                 440                 445             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    450                 455                 460                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
465                 470                 475                 480 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                485                 490                 495     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile 
            500                 505                 510         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        515                 520                 525             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    530                 535                 540                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
545                 550                 555                 560 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                565                 570                 575     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            580                 585                 590         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        595                 600                 605             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620             


<210>  34
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  zc62939

<400>  34
tccggcttgg aggatgggcc ggtgacgcga tcgctccaca acatccaggt g                51


<210>  35
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  zc62938

<400>  35
cacctggatg ttgtggagcg atcgcgtcac cggcccatcc tccaagccgg a                51


<210>  36
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  pZMP31solFGFR2alphaIIIc(145_377)Fc5


<220>
<221>  CDS
<222>  (1)..(1503)

<400>  36
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga agt gag aac agt aac aac aag aga gca cca tac tgg acc        144
Phe Arg Arg Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr           
        35                  40                  45                        

aac aca gaa aag atg gaa aag cgg ctc cat gct gtg cct gcg gcc aac        192
Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn           
    50                  55                  60                            

act gtc aag ttt cgc tgc cca gcc ggg ggg aac cca atg cca acc atg        240
Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met           
65                  70                  75                  80            

cgg tgg ctg aaa aac ggg aag gag ttt aag cag gag cat cgc att gga        288
Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly           
                85                  90                  95                

ggc tac aag gta cga aac cag cac tgg agc ctc att atg gaa agt gtg        336
Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val           
            100                 105                 110                   

gtc cca tct gac aag gga aat tat acc tgt gtg gtg gag aat gaa tac        384
Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr           
        115                 120                 125                       

ggg tcc atc aat cac acg tac cac ctg gat gtt gtg gag cga tcg cct        432
Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro           
    130                 135                 140                           

cac cgg ccc atc ctc caa gcc gga ctg ccg gca aat gcc tcc aca gtg        480
His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val           
145                 150                 155                 160           

gtc gga gga gac gta gag ttt gtc tgc aag gtt tac agt gat gcc cag        528
Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln           
                165                 170                 175               

ccc cac atc cag tgg atc aag cac gtg gaa aag aac ggc agt aaa tac        576
Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr           
            180                 185                 190                   

ggg ccc gac ggg ctg ccc tac ctc aag gtt ctc aag gcc gcc ggt gtt        624
Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val           
        195                 200                 205                       

aac acc acg gac aaa gag att gag gtt ctc tat att cgg aat gta act        672
Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr           
    210                 215                 220                           

ttt gag gac gct ggg gaa tat acg tgc ttg gcg ggt aat tct att ggg        720
Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly           
225                 230                 235                 240           

ata tcc ttt cac tct gca tgg ttg aca gtt ctg cca gcg cct gga aga        768
Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg           
                245                 250                 255               

gaa aag gag att aca gct tcc cca gac tac ctg gag gag ccc aaa tct        816
Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Glu Pro Lys Ser           
            260                 265                 270                   

tca gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa gcc gag        864
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu           
        275                 280                 285                       

ggg gca ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc        912
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu           
    290                 295                 300                           

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc        960
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser           
305                 310                 315                 320           

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag       1008
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu           
                325                 330                 335               

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg       1056
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr           
            340                 345                 350                   

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat       1104
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn           
        355                 360                 365                       

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca tcc tcc       1152
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser           
    370                 375                 380                           

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag       1200
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln           
385                 390                 395                 400           

gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc       1248
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val           
                405                 410                 415               

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg       1296
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val           
            420                 425                 430                   

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct       1344
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro           
        435                 440                 445                       

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc       1392
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr           
    450                 455                 460                           

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg       1440
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val           
465                 470                 475                 480           

atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg       1488
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu           
                485                 490                 495               

tct ccg ggt aaa taa                                                   1503
Ser Pro Gly Lys                                                           
            500                                                           


<210>  37
<211>  500
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  37

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr 
        35                  40                  45              


Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn 
    50                  55                  60                  


Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met 
65                  70                  75                  80  


Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly 
                85                  90                  95      


Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val 
            100                 105                 110         


Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr 
        115                 120                 125             


Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro 
    130                 135                 140                 


His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val 
145                 150                 155                 160 


Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln 
                165                 170                 175     


Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr 
            180                 185                 190         


Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val 
        195                 200                 205             


Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr 
    210                 215                 220                 


Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly 
225                 230                 235                 240 


Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg 
                245                 250                 255     


Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys 
            500 


<210>  38
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  zc62935

<400>  38
caggaaatcc atgccgagtt gagacgcttc cgtagaagtg agaacagtaa caacaagaga       60


<210>  39
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  pZMP31solFGFR2alphaIIIc(145_377)(S252W)Fc5


<220>
<221>  CDS
<222>  (1)..(1503)

<400>  39
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga agt gag aac agt aac aac aag aga gca cca tac tgg acc        144
Phe Arg Arg Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr           
        35                  40                  45                        

aac aca gaa aag atg gaa aag cgg ctc cat gct gtg cct gcg gcc aac        192
Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn           
    50                  55                  60                            

act gtc aag ttt cgc tgc cca gcc ggg ggg aac cca atg cca acc atg        240
Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met           
65                  70                  75                  80            

cgg tgg ctg aaa aac ggg aag gag ttt aag cag gag cat cgc att gga        288
Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly           
                85                  90                  95                

ggc tac aag gta cga aac cag cac tgg agc ctc att atg gaa agt gtg        336
Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val           
            100                 105                 110                   

gtc cca tct gac aag gga aat tat acc tgt gtg gtg gag aat gaa tac        384
Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr           
        115                 120                 125                       

ggg tcc atc aat cac acg tac cac ctg gat gtt gtg gag cga tgg cct        432
Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val Glu Arg Trp Pro           
    130                 135                 140                           

cac cgg ccc atc ctc caa gcc gga ctg ccg gca aat gcc tcc aca gtg        480
His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val           
145                 150                 155                 160           

gtc gga gga gac gta gag ttt gtc tgc aag gtt tac agt gat gcc cag        528
Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln           
                165                 170                 175               

ccc cac atc cag tgg atc aag cac gtg gaa aag aac ggc agt aaa tac        576
Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr           
            180                 185                 190                   

ggg ccc gac ggg ctg ccc tac ctc aag gtt ctc aag gcc gcc ggt gtt        624
Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val           
        195                 200                 205                       

aac acc acg gac aaa gag att gag gtt ctc tat att cgg aat gta act        672
Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr           
    210                 215                 220                           

ttt gag gac gct ggg gaa tat acg tgc ttg gcg ggt aat tct att ggg        720
Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly           
225                 230                 235                 240           

ata tcc ttt cac tct gca tgg ttg aca gtt ctg cca gcg cct gga aga        768
Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg           
                245                 250                 255               

gaa aag gag att aca gct tcc cca gac tac ctg gag gag ccc aaa tct        816
Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Glu Pro Lys Ser           
            260                 265                 270                   

tca gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa gcc gag        864
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu           
        275                 280                 285                       

ggg gca ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc        912
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu           
    290                 295                 300                           

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc        960
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser           
305                 310                 315                 320           

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag       1008
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu           
                325                 330                 335               

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg       1056
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr           
            340                 345                 350                   

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat       1104
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn           
        355                 360                 365                       

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca tcc tcc       1152
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser           
    370                 375                 380                           

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag       1200
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln           
385                 390                 395                 400           

gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc       1248
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val           
                405                 410                 415               

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg       1296
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val           
            420                 425                 430                   

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct       1344
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro           
        435                 440                 445                       

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc       1392
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr           
    450                 455                 460                           

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg       1440
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val           
465                 470                 475                 480           

atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg       1488
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu           
                485                 490                 495               

tct ccg ggt aaa taa                                                   1503
Ser Pro Gly Lys                                                           
            500                                                           


<210>  40
<211>  500
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  40

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr 
        35                  40                  45              


Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn 
    50                  55                  60                  


Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met 
65                  70                  75                  80  


Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly 
                85                  90                  95      


Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val 
            100                 105                 110         


Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr 
        115                 120                 125             


Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val Glu Arg Trp Pro 
    130                 135                 140                 


His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val 
145                 150                 155                 160 


Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln 
                165                 170                 175     


Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr 
            180                 185                 190         


Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val 
        195                 200                 205             


Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr 
    210                 215                 220                 


Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly 
225                 230                 235                 240 


Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg 
                245                 250                 255     


Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys 
            500 


<210>  41
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  pZMP31solFGFR2alphaIIIc(145_377)(P253R)Fc5


<220>
<221>  CDS
<222>  (1)..(1503)

<400>  41
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga agt gag aac agt aac aac aag aga gca cca tac tgg acc        144
Phe Arg Arg Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr           
        35                  40                  45                        

aac aca gaa aag atg gaa aag cgg ctc cat gct gtg cct gcg gcc aac        192
Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn           
    50                  55                  60                            

act gtc aag ttt cgc tgc cca gcc ggg ggg aac cca atg cca acc atg        240
Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met           
65                  70                  75                  80            

cgg tgg ctg aaa aac ggg aag gag ttt aag cag gag cat cgc att gga        288
Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly           
                85                  90                  95                

ggc tac aag gta cga aac cag cac tgg agc ctc att atg gaa agt gtg        336
Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val           
            100                 105                 110                   

gtc cca tct gac aag gga aat tat acc tgt gtg gtg gag aat gaa tac        384
Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr           
        115                 120                 125                       

ggg tcc atc aat cac acg tac cac ctg gat gtt gtg gag cga tcg cgt        432
Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Arg           
    130                 135                 140                           

cac cgg ccc atc ctc caa gcc gga ctg ccg gca aat gcc tcc aca gtg        480
His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val           
145                 150                 155                 160           

gtc gga gga gac gta gag ttt gtc tgc aag gtt tac agt gat gcc cag        528
Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln           
                165                 170                 175               

ccc cac atc cag tgg atc aag cac gtg gaa aag aac ggc agt aaa tac        576
Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr           
            180                 185                 190                   

ggg ccc gac ggg ctg ccc tac ctc aag gtt ctc aag gcc gcc ggt gtt        624
Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val           
        195                 200                 205                       

aac acc acg gac aaa gag att gag gtt ctc tat att cgg aat gta act        672
Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr           
    210                 215                 220                           

ttt gag gac gct ggg gaa tat acg tgc ttg gcg ggt aat tct att ggg        720
Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly           
225                 230                 235                 240           

ata tcc ttt cac tct gca tgg ttg aca gtt ctg cca gcg cct gga aga        768
Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg           
                245                 250                 255               

gaa aag gag att aca gct tcc cca gac tac ctg gag gag ccc aaa tct        816
Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Glu Pro Lys Ser           
            260                 265                 270                   

tca gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa gcc gag        864
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu           
        275                 280                 285                       

ggg gca ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc        912
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu           
    290                 295                 300                           

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc        960
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser           
305                 310                 315                 320           

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag       1008
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu           
                325                 330                 335               

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg       1056
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr           
            340                 345                 350                   

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat       1104
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn           
        355                 360                 365                       

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca tcc tcc       1152
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser           
    370                 375                 380                           

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag       1200
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln           
385                 390                 395                 400           

gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc       1248
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val           
                405                 410                 415               

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg       1296
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val           
            420                 425                 430                   

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct       1344
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro           
        435                 440                 445                       

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc       1392
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr           
    450                 455                 460                           

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg       1440
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val           
465                 470                 475                 480           

atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg       1488
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu           
                485                 490                 495               

tct ccg ggt aaa taa                                                   1503
Ser Pro Gly Lys                                                           
            500                                                           


<210>  42
<211>  500
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  42

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr 
        35                  40                  45              


Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn 
    50                  55                  60                  


Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met 
65                  70                  75                  80  


Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly 
                85                  90                  95      


Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val 
            100                 105                 110         


Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr 
        115                 120                 125             


Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Arg 
    130                 135                 140                 


His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val 
145                 150                 155                 160 


Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln 
                165                 170                 175     


Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr 
            180                 185                 190         


Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val 
        195                 200                 205             


Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr 
    210                 215                 220                 


Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly 
225                 230                 235                 240 


Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg 
                245                 250                 255     


Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys 
            500 


<210>  43
<211>  744
<212>  DNA
<213>  Artificial

<220>
<223>  c870.1 e6 scFv


<220>
<221>  CDS
<222>  (1)..(744)

<400>  43
gaa gtt caa ttg tta gag tct ggt ggc ggt ctt gtt cag cct ggt ggt         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tct tta cgt ctt tct tgc gct gct tcc gga ttc act ttc tct ggt tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr           
            20                  25                  30                    

att atg tgg tgg gtt cgc caa gct cct ggt aaa ggt ttg gag tgg gtt        144
Ile Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tct gtt atc tct cct tct ggt ggc gat act tgg tat gct gac tcc gtt        192
Ser Val Ile Ser Pro Ser Gly Gly Asp Thr Trp Tyr Ala Asp Ser Val           
    50                  55                  60                            

aaa ggt cgc ttc act atc tct aga gac aac tct aag aat act ctc tac        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

tta cag atg aac agc tta agg gct gag gac acg gcc gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcc aca gcg gga gac tac tgg ggc cag ggc acc ctg gtc acc gtc tca        336
Ala Thr Ala Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser           
            100                 105                 110                   

agc ggt ggt ggt ggt tct ggc ggc ggc ggc tcc ggc ggg ggt gga agt        384
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser           
        115                 120                 125                       

ggt ggt ggt ggt tct ggt ggt ggt ggt tct cag agc gtg ttg act cag        432
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln           
    130                 135                 140                           

cca ccc tca gcg tct ggg acc ccc ggg cag agg gtc acc atc tct tgt        480
Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys           
145                 150                 155                 160           

tct gga agc agc tcc aac atc gga agg aat cct gta aac tgg tac cag        528
Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Pro Val Asn Trp Tyr Gln           
                165                 170                 175               

cag ctc cca gga acg gcc ccc aaa ctc ctc atc tat ggt gat aat cag        576
Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asp Asn Gln           
            180                 185                 190                   

cgg ccc tca ggg gtc cct gac cga ttc tct ggc tcc aaa tct ggc acc        624
Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr           
        195                 200                 205                       

tca gcc tcc ctg gcc atc agt ggg ctc cag tct gag gat gag gct gat        672
Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp           
    210                 215                 220                           

tat tac tgt gca gca tgg gat gac agc ctg aat ggt gtg gta ttc ggc        720
Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val Phe Gly           
225                 230                 235                 240           

gga ggg acc aag ctg acc gtc cta                                        744
Gly Gly Thr Lys Leu Thr Val Leu                                           
                245                                                       


<210>  44
<211>  248
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  44

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ser Gly Gly Asp Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Pro Val Asn Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asp Asn Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  45
<211>  744
<212>  DNA
<213>  Artificial

<220>
<223>  1094.1 scFv


<220>
<221>  CDS
<222>  (1)..(744)

<400>  45
gaa gtt caa ttg tta gag tct ggt ggc ggt ctt gtt cag cct ggt ggt         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tct tta cgt ctt tct tgc gct gct tcc gga ttc act ttc tct ggt tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr           
            20                  25                  30                    

att atg tgg tgg gtt cgc caa gct cct ggt aaa ggt ttg gag tgg gtt        144
Ile Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tct gtt atc tct cct tct ggt ggc gat act tgg tat gct gac tcc gtt        192
Ser Val Ile Ser Pro Ser Gly Gly Asp Thr Trp Tyr Ala Asp Ser Val           
    50                  55                  60                            

aaa ggt cgc ttc act atc tct aga gac aac tct aag aat act ctc tac        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ttg cag atg aac agc tta agg gct gag gac acg gcc gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcc aca gcg gga gac tac tgg ggc cag ggc acc ctg gtc act gtc tca        336
Ala Thr Ala Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser           
            100                 105                 110                   

agc ggt ggt ggt ggt tct ggc ggc ggc ggc tcc ggc ggg ggt gga agt        384
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser           
        115                 120                 125                       

ggt ggt ggt ggt tct ggt ggt ggt ggt tct cag agc gaa ttg act cag        432
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Glu Leu Thr Gln           
    130                 135                 140                           

cca ccc tca gcg tct ggg acc ccc ggg cag ggg gtc acc atc tct tgt        480
Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Gly Val Thr Ile Ser Cys           
145                 150                 155                 160           

tct gga agt agt tcc aac atc gga agt aat act gtt cag tgg tac cag        528
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Gln Trp Tyr Gln           
                165                 170                 175               

cag ttc cca gga agg gcc ccc aaa ctc ctc atc tat agt aat aat cgg        576
Gln Phe Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Arg           
            180                 185                 190                   

cgg ccc tca ggg gtc cct gac cga ttc tct ggt tcc aag tct ggc acc        624
Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr           
        195                 200                 205                       

tca gcc tcc ctg gcc atc agt ggg ctc cgg tcc gag gat gaa gct gat        672
Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp           
    210                 215                 220                           

tat tac tgt gca gca tgg gat gac agc ctg agt gtc gtg gta ttc ggc        720
Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Val Val Val Phe Gly           
225                 230                 235                 240           

gga ggg acc aag ctg acc gtc cta                                        744
Gly Gly Thr Lys Leu Thr Val Leu                                           
                245                                                       


<210>  46
<211>  248
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  46

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ser Gly Gly Asp Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Glu Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Gly Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Gln Trp Tyr Gln 
                165                 170                 175     


Gln Phe Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Arg 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Val Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  47
<211>  331
<212>  DNA
<213>  Homo Sapien

<400>  47
cagagcgaat tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga aggaatcctg taaactggta ccagcacctc      120

ccaggaacgg cccccaaact cctcatctat ggtgataatc agcggccctc aggggtccct      180

gaccgattct ctggctccag gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtgtggta      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  48
<211>  110
<212>  PRT
<213>  Homo sapien

<400>  48

Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  49
<211>  340
<212>  DNA
<213>  Homo sapien

<400>  49
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ggttacatta tgtggtgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctgtt atctctcctt ctggtggcga tacttggtat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttacagatga acagcttaag ggctgaggac acggccgtgt attactgtgc cacagcggga      300

gactactggg gccagggcac cctggtcacc gtctcaagcg                            340


<210>  50
<211>  113
<212>  PRT
<213>  Homo sapien

<400>  50

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ser Gly Gly Asp Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  51
<211>  744
<212>  DNA
<213>  Artificial

<220>
<223>  c870.1scFv cDNA

<400>  51
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ggttacatta tgtggtgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctgtt atctctcctt ctggtggcga tacttggtat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttacagatga acagcttaag ggctgaggac acggccgtgt attactgtgc cacagcggga      300

gactactggg gccagggcac cctggtcacc gtctcaagcg gtggtggtgg ttctggcggc      360

ggcggctccg gcgggggtgg aagtggtggt ggtggttctg gtggtggtgg ttctcagagc      420

gaattgactc agccaccctc agcgtctggg acccccgggc agagggtcac catctcttgt      480

tctggaagca gctccaacat cggaaggaat cctgtaaact ggtaccagca cctcccagga      540

acggccccca aactcctcat ctatggtgat aatcagcggc cctcaggggt ccctgaccga      600

ttctctggct ccaggtctgg cacctcagcc tccctggcca tcagtgggct ccagtctgag      660

gatgaggctg attattactg tgcagcatgg gatgacagcc tgaatggtgt ggtattcggc      720

ggagggacca agctgaccgt ccta                                             744


<210>  52
<211>  248
<212>  PRT
<213>  Artificial

<220>
<223>  c870.1 scFv

<400>  52

Glu Val Gly Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ser Gly Gly Asp Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Glu Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Pro Val Asn Trp Tyr Gln 
                165                 170                 175     


His Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asp Asn Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  53
<211>  331
<212>  DNA
<213>  Homo sapien

<400>  53
cagagcgaat tgactcagcc accctcagcg tctgggaccc ccgggcaggg ggtcaccatc       60

tcttgttctg gaagtagttc caacatcgga agtaatactg ttcagtggta ccagcagttc      120

ccaggaaggg cccccaaact cctcatctat agtaataatc ggcggccctc aggggtccct      180

gaccgattct ctggttccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatt aggctgatta ttactgtgca gcatgggatg acagcctgag tgtcgtggta      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  54
<211>  110
<212>  PRT
<213>  Homo sapien

<400>  54

Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Gly Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Gln Trp Tyr Gln Gln Phe Pro Gly Arg Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Gln Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  55
<211>  340
<212>  DNA
<213>  Homo sapien

<400>  55
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ggttacatta tgtggtgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctgtt atctctcctt ctggtggcga tacttggtat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc cacagcggga      300

gactactggg gccagggcac cctggtcact gtctcaagcg                            340


<210>  56
<211>  114
<212>  PRT
<213>  Homo sapien

<400>  56

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ser Gly Gly Asp Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Ala Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  57
<211>  2274
<212>  DNA
<213>  Artificial

<220>
<223>  FGFR3(143-375)(S249W)Fc5 c1094.1 pZMP31


<220>
<221>  CDS
<222>  (1)..(2274)

<400>  57
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga gac aca ggt gtg gac aca ggg gcc cct tac tgg aca cgg        144
Phe Arg Arg Asp Thr Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg           
        35                  40                  45                        

ccc gag cgg atg gac aag aag ctg ctg gcc gtg ccg gcc gcc aac acc        192
Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr           
    50                  55                  60                            

gtc cgc ttc cgc tgc cca gcc gct ggc aac ccc act ccc tcc atc tcc        240
Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser           
65                  70                  75                  80            

tgg ctg aag aac ggc agg gag ttc cgc ggc gag cac cgc att gga ggc        288
Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly           
                85                  90                  95                

atc aag ctg cgg cat cag cag tgg agc ctg gtc atg gaa agc gtg gtg        336
Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu Ser Val Val           
            100                 105                 110                   

ccc tcg gac cgc ggc aac tac acc tgc gtc gtg gag aac aag ttt ggc        384
Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly           
        115                 120                 125                       

agc atc cgg cag acg tac acg ctg gac gtg ctg gag cgc tgg ccg cac        432
Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu Arg Trp Pro His           
    130                 135                 140                           

cgg ccc atc ctg cag gcg ggg ctg ccg gcc aac cag acg gcg gtg ctg        480
Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu           
145                 150                 155                 160           

ggc agc gac gtg gag ttc cac tgc aag gtg tac agt gac gca cag ccc        528
Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro           
                165                 170                 175               

cac atc cag tgg ctc aag cac gtg gag gtg aat ggc agc aag gtg ggc        576
His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly           
            180                 185                 190                   

ccg gac ggc aca ccc tac gtt acc gtg ctc aag acg gcg ggc gct aac        624
Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn           
        195                 200                 205                       

acc acc gac aag gag cta gag gtt ctc tcc ttg cac aac gtc acc ttt        672
Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His Asn Val Thr Phe           
    210                 215                 220                           

gag gac gcc ggg gag tac acc tgc ctg gcg ggc aat tct att ggg ttt        720
Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe           
225                 230                 235                 240           

tct cat cac tct gcg tgg ctg gtg gtg ctg cca gcc gag gag gag ctg        768
Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu           
                245                 250                 255               

gtg gag gct gac gag gcg ggc agt gtg tat gca ggc gag ccc aaa tct        816
Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly Glu Pro Lys Ser           
            260                 265                 270                   

tca gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa gcc gag        864
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu           
        275                 280                 285                       

ggg gca ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc        912
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu           
    290                 295                 300                           

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc        960
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser           
305                 310                 315                 320           

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag       1008
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu           
                325                 330                 335               

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg       1056
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr           
            340                 345                 350                   

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat       1104
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn           
        355                 360                 365                       

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca tcc tcc       1152
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser           
    370                 375                 380                           

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag       1200
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln           
385                 390                 395                 400           

gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc       1248
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val           
                405                 410                 415               

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg       1296
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val           
            420                 425                 430                   

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct       1344
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro           
        435                 440                 445                       

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc       1392
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr           
    450                 455                 460                           

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg       1440
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val           
465                 470                 475                 480           

atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg       1488
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu           
                485                 490                 495               

tct ccg ggt ggt ggc ggg ggt tcg ggt gga gga ggt tct gaa gtt caa       1536
Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln           
            500                 505                 510                   

ttg tta gag tct ggt ggc ggt ctt gtt cag cct ggt ggt tct tta cgt       1584
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg           
        515                 520                 525                       

ctt tct tgc gct gct tcc gga ttc act ttc tct ggt tac att atg tgg       1632
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr Ile Met Trp           
    530                 535                 540                           

tgg gtt cgc caa gct cct ggt aaa ggt ttg gag tgg gtt tct gtt atc       1680
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile           
545                 550                 555                 560           

tct cct tct ggt ggc gat act tgg tat gct gac tcc gtt aaa ggt cgc       1728
Ser Pro Ser Gly Gly Asp Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg           
                565                 570                 575               

ttc act atc tct aga gac aac tct aag aat act ctc tac ttg cag atg       1776
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met           
            580                 585                 590                   

aac agc tta agg gct gag gac acg gcc gtg tat tac tgt gcc aca gcg       1824
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Ala           
        595                 600                 605                       

gga gac tac tgg ggc cag ggc acc ctg gtc act gtc tca agc ggt ggt       1872
Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly           
    610                 615                 620                           

ggt ggt tct ggc ggc ggc ggc tcc ggc ggg ggt gga agt ggt ggt ggt       1920
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly           
625                 630                 635                 640           

ggt tct ggt ggt ggt ggt tct cag agc gaa ttg act cag cca ccc tca       1968
Gly Ser Gly Gly Gly Gly Ser Gln Ser Glu Leu Thr Gln Pro Pro Ser           
                645                 650                 655               

gcg tct ggg acc ccc ggg cag ggg gtc acc atc tct tgt tct gga agt       2016
Ala Ser Gly Thr Pro Gly Gln Gly Val Thr Ile Ser Cys Ser Gly Ser           
            660                 665                 670                   

agt tcc aac atc gga agt aat act gtt cag tgg tac cag cag ttc cca       2064
Ser Ser Asn Ile Gly Ser Asn Thr Val Gln Trp Tyr Gln Gln Phe Pro           
        675                 680                 685                       

gga agg gcc ccc aaa ctc ctc atc tat agt aat aat cgg cgg ccc tca       2112
Gly Arg Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Arg Arg Pro Ser           
    690                 695                 700                           

ggg gtc cct gac cga ttc tct ggt tcc aag tct ggc acc tca gcc tcc       2160
Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser           
705                 710                 715                 720           

ctg gcc atc agt ggg ctc cgg tcc gag gat gaa gct gat tat tac tgt       2208
Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys           
                725                 730                 735               

gca gca tgg gat gac agc ctg agt gtc gtg gta ttc ggc gga ggg acc       2256
Ala Ala Trp Asp Asp Ser Leu Ser Val Val Val Phe Gly Gly Gly Thr           
            740                 745                 750                   

aag ctg acc gtc cta taa                                               2274
Lys Leu Thr Val Leu                                                       
        755                                                               


<210>  58
<211>  757
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  58

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Asp Thr Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg 
        35                  40                  45              


Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr 
    50                  55                  60                  


Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser 
65                  70                  75                  80  


Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly 
                85                  90                  95      


Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu Ser Val Val 
            100                 105                 110         


Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly 
        115                 120                 125             


Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu Arg Trp Pro His 
    130                 135                 140                 


Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu 
145                 150                 155                 160 


Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro 
                165                 170                 175     


His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly 
            180                 185                 190         


Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn 
        195                 200                 205             


Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His Asn Val Thr Phe 
    210                 215                 220                 


Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe 
225                 230                 235                 240 


Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu 
                245                 250                 255     


Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
            500                 505                 510         


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        515                 520                 525             


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr Ile Met Trp 
    530                 535                 540                 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile 
545                 550                 555                 560 


Ser Pro Ser Gly Gly Asp Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg 
                565                 570                 575     


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
            580                 585                 590         


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Ala 
        595                 600                 605             


Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gln Ser Glu Leu Thr Gln Pro Pro Ser 
                645                 650                 655     


Ala Ser Gly Thr Pro Gly Gln Gly Val Thr Ile Ser Cys Ser Gly Ser 
            660                 665                 670         


Ser Ser Asn Ile Gly Ser Asn Thr Val Gln Trp Tyr Gln Gln Phe Pro 
        675                 680                 685             


Gly Arg Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Arg Arg Pro Ser 
    690                 695                 700                 


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
705                 710                 715                 720 


Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                725                 730                 735     


Ala Ala Trp Asp Asp Ser Leu Ser Val Val Val Phe Gly Gly Gly Thr 
            740                 745                 750         


Lys Leu Thr Val Leu 
        755         


<210>  59
<211>  2634
<212>  DNA
<213>  Artificial

<220>
<223>  FGFR3(23-375)(S249W)Fc5 c1094.1 pZMP31


<220>
<221>  CDS
<222>  (1)..(2634)

<400>  59
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga gag tcc ttg ggg acg gag cag cgc gtc gtg ggg cga gcg        144
Phe Arg Arg Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala           
        35                  40                  45                        

gca gaa gtc ccg ggc cca gag ccc ggc cag cag gag cag ttg gtc ttc        192
Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe           
    50                  55                  60                            

ggc agc ggg gat gct gtg gag ctg agc tgt ccc ccg ccc ggg ggt ggt        240
Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly           
65                  70                  75                  80            

ccc atg ggg ccc act gtc tgg gtc aag gat ggc aca ggg ctg gtg ccc        288
Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro           
                85                  90                  95                

tcg gag cgt gtc ctg gtg ggg ccc cag cgg ctg cag gtg ctg aat gcc        336
Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala           
            100                 105                 110                   

tcc cac gag gac tcc ggg gcc tac agc tgc cgg cag cgg ctc acg cag        384
Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln           
        115                 120                 125                       

cgc gta ctg tgc cac ttc agt gtg cgg gtg aca gac gct cca tcc tcg        432
Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser           
    130                 135                 140                           

gga gat gac gaa gac ggg gag gac gag gct gag gac aca ggt gtg gac        480
Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp           
145                 150                 155                 160           

aca ggg gcc cct tac tgg aca cgg ccc gag cgg atg gac aag aag ctg        528
Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu           
                165                 170                 175               

ctg gcc gtg ccg gcc gcc aac acc gtc cgc ttc cgc tgc cca gcc gct        576
Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala           
            180                 185                 190                   

ggc aac ccc act ccc tcc atc tcc tgg ctg aag aac ggc agg gag ttc        624
Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe           
        195                 200                 205                       

cgc ggc gag cac cgc att gga ggc atc aag ctg cgg cat cag cag tgg        672
Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp           
    210                 215                 220                           

agc ctg gtc atg gaa agc gtg gtg ccc tcg gac cgc ggc aac tac acc        720
Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr           
225                 230                 235                 240           

tgc gtc gtg gag aac aag ttt ggc agc atc cgg cag acg tac acg ctg        768
Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu           
                245                 250                 255               

gac gtg ctg gag cgc tgg ccg cac cgg ccc atc ctg cag gcg ggg ctg        816
Asp Val Leu Glu Arg Trp Pro His Arg Pro Ile Leu Gln Ala Gly Leu           
            260                 265                 270                   

ccg gcc aac cag acg gcg gtg ctg ggc agc gac gtg gag ttc cac tgc        864
Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys           
        275                 280                 285                       

aag gtg tac agt gac gca cag ccc cac atc cag tgg ctc aag cac gtg        912
Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val           
    290                 295                 300                           

gag gtg aat ggc agc aag gtg ggc ccg gac ggc aca ccc tac gtt acc        960
Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr           
305                 310                 315                 320           

gtg ctc aag acg gcg ggc gct aac acc acc gac aag gag cta gag gtt       1008
Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val           
                325                 330                 335               

ctc tcc ttg cac aac gtc acc ttt gag gac gcc ggg gag tac acc tgc       1056
Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys           
            340                 345                 350                   

ctg gcg ggc aat tct att ggg ttt tct cat cac tct gcg tgg ctg gtg       1104
Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val           
        355                 360                 365                       

gtg ctg cca gcc gag gag gag ctg gtg gag gct gac gag gcg ggc agt       1152
Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser           
    370                 375                 380                           

gtg tat gca ggc gag ccc aaa tct tca gac aaa act cac aca tgc cca       1200
Val Tyr Ala Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro           
385                 390                 395                 400           

ccg tgc cca gca cct gaa gcc gag ggg gca ccg tca gtc ttc ctc ttc       1248
Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe           
                405                 410                 415               

ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc       1296
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val           
            420                 425                 430                   

aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc       1344
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe           
        435                 440                 445                       

aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg       1392
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro           
    450                 455                 460                           

cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc       1440
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr           
465                 470                 475                 480           

gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc       1488
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val           
                485                 490                 495               

tcc aac aaa gcc ctc cca tcc tcc atc gag aaa acc atc tcc aaa gcc       1536
Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala           
            500                 505                 510                   

aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg       1584
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg           
        515                 520                 525                       

gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc       1632
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly           
    530                 535                 540                           

ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg       1680
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro           
545                 550                 555                 560           

gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc       1728
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser           
                565                 570                 575               

ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag       1776
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln           
            580                 585                 590                   

ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac       1824
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His           
        595                 600                 605                       

tac acg cag aag agc ctc tcc ctg tct ccg ggt ggt ggc ggg ggt tcg       1872
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser           
    610                 615                 620                           

ggt gga gga ggt tct gaa gtt caa ttg tta gag tct ggt ggc ggt ctt       1920
Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu           
625                 630                 635                 640           

gtt cag cct ggt ggt tct tta cgt ctt tct tgc gct gct tcc gga ttc       1968
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe           
                645                 650                 655               

act ttc tct ggt tac att atg tgg tgg gtt cgc caa gct cct ggt aaa       2016
Thr Phe Ser Gly Tyr Ile Met Trp Trp Val Arg Gln Ala Pro Gly Lys           
            660                 665                 670                   

ggt ttg gag tgg gtt tct gtt atc tct cct tct ggt ggc gat act tgg       2064
Gly Leu Glu Trp Val Ser Val Ile Ser Pro Ser Gly Gly Asp Thr Trp           
        675                 680                 685                       

tat gct gac tcc gtt aaa ggt cgc ttc act atc tct aga gac aac tct       2112
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser           
    690                 695                 700                           

aag aat act ctc tac ttg cag atg aac agc tta agg gct gag gac acg       2160
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr           
705                 710                 715                 720           

gcc gtg tat tac tgt gcc aca gcg gga gac tac tgg ggc cag ggc acc       2208
Ala Val Tyr Tyr Cys Ala Thr Ala Gly Asp Tyr Trp Gly Gln Gly Thr           
                725                 730                 735               

ctg gtc act gtc tca agc ggt ggt ggt ggt tct ggc ggc ggc ggc tcc       2256
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser           
            740                 745                 750                   

ggc ggg ggt gga agt ggt ggt ggt ggt tct ggt ggt ggt ggt tct cag       2304
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln           
        755                 760                 765                       

agc gaa ttg act cag cca ccc tca gcg tct ggg acc ccc ggg cag ggg       2352
Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Gly           
    770                 775                 780                           

gtc acc atc tct tgt tct gga agt agt tcc aac atc gga agt aat act       2400
Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr           
785                 790                 795                 800           

gtt cag tgg tac cag cag ttc cca gga agg gcc ccc aaa ctc ctc atc       2448
Val Gln Trp Tyr Gln Gln Phe Pro Gly Arg Ala Pro Lys Leu Leu Ile           
                805                 810                 815               

tat agt aat aat cgg cgg ccc tca ggg gtc cct gac cga ttc tct ggt       2496
Tyr Ser Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly           
            820                 825                 830                   

tcc aag tct ggc acc tca gcc tcc ctg gcc atc agt ggg ctc cgg tcc       2544
Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser           
        835                 840                 845                       

gag gat gaa gct gat tat tac tgt gca gca tgg gat gac agc ctg agt       2592
Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser           
    850                 855                 860                           

gtc gtg gta ttc ggc gga ggg acc aag ctg acc gtc cta taa               2634
Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                       
865                 870                 875                               


<210>  60
<211>  877
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  60

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala 
        35                  40                  45              


Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe 
    50                  55                  60                  


Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly 
65                  70                  75                  80  


Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro 
                85                  90                  95      


Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala 
            100                 105                 110         


Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln 
        115                 120                 125             


Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser 
    130                 135                 140                 


Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp 
145                 150                 155                 160 


Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu 
                165                 170                 175     


Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala 
            180                 185                 190         


Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe 
        195                 200                 205             


Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp 
    210                 215                 220                 


Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr 
225                 230                 235                 240 


Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu 
                245                 250                 255     


Asp Val Leu Glu Arg Trp Pro His Arg Pro Ile Leu Gln Ala Gly Leu 
            260                 265                 270         


Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys 
        275                 280                 285             


Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val 
    290                 295                 300                 


Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr 
305                 310                 315                 320 


Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val 
                325                 330                 335     


Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys 
            340                 345                 350         


Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val 
        355                 360                 365             


Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser 
    370                 375                 380                 


Val Tyr Ala Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
385                 390                 395                 400 


Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 
                405                 410                 415     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            420                 425                 430         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        435                 440                 445             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    450                 455                 460                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
465                 470                 475                 480 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                485                 490                 495     


Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            500                 505                 510         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        515                 520                 525             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    530                 535                 540                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
545                 550                 555                 560 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                565                 570                 575     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            580                 585                 590         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        595                 600                 605             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
625                 630                 635                 640 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                645                 650                 655     


Thr Phe Ser Gly Tyr Ile Met Trp Trp Val Arg Gln Ala Pro Gly Lys 
            660                 665                 670         


Gly Leu Glu Trp Val Ser Val Ile Ser Pro Ser Gly Gly Asp Thr Trp 
        675                 680                 685             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    690                 695                 700                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
705                 710                 715                 720 


Ala Val Tyr Tyr Cys Ala Thr Ala Gly Asp Tyr Trp Gly Gln Gly Thr 
                725                 730                 735     


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        755                 760                 765             


Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Gly 
    770                 775                 780                 


Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr 
785                 790                 795                 800 


Val Gln Trp Tyr Gln Gln Phe Pro Gly Arg Ala Pro Lys Leu Leu Ile 
                805                 810                 815     


Tyr Ser Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 
            820                 825                 830         


Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser 
        835                 840                 845             


Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser 
    850                 855                 860                 


Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
865                 870                 875         


<210>  61
<211>  2274
<212>  DNA
<213>  Artificial

<220>
<223>  FGFR3(143-375)(S249W)Fc5 c870e6 pZMP31


<220>
<221>  CDS
<222>  (1)..(2274)

<400>  61
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga gac aca ggt gtg gac aca ggg gcc cct tac tgg aca cgg        144
Phe Arg Arg Asp Thr Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg           
        35                  40                  45                        

ccc gag cgg atg gac aag aag ctg ctg gcc gtg ccg gcc gcc aac acc        192
Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr           
    50                  55                  60                            

gtc cgc ttc cgc tgc cca gcc gct ggc aac ccc act ccc tcc atc tcc        240
Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser           
65                  70                  75                  80            

tgg ctg aag aac ggc agg gag ttc cgc ggc gag cac cgc att gga ggc        288
Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly           
                85                  90                  95                

atc aag ctg cgg cat cag cag tgg agc ctg gtc atg gaa agc gtg gtg        336
Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu Ser Val Val           
            100                 105                 110                   

ccc tcg gac cgc ggc aac tac acc tgc gtc gtg gag aac aag ttt ggc        384
Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly           
        115                 120                 125                       

agc atc cgg cag acg tac acg ctg gac gtg ctg gag cgc tgg ccg cac        432
Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu Arg Trp Pro His           
    130                 135                 140                           

cgg ccc atc ctg cag gcg ggg ctg ccg gcc aac cag acg gcg gtg ctg        480
Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu           
145                 150                 155                 160           

ggc agc gac gtg gag ttc cac tgc aag gtg tac agt gac gca cag ccc        528
Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro           
                165                 170                 175               

cac atc cag tgg ctc aag cac gtg gag gtg aat ggc agc aag gtg ggc        576
His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly           
            180                 185                 190                   

ccg gac ggc aca ccc tac gtt acc gtg ctc aag acg gcg ggc gct aac        624
Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn           
        195                 200                 205                       

acc acc gac aag gag cta gag gtt ctc tcc ttg cac aac gtc acc ttt        672
Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His Asn Val Thr Phe           
    210                 215                 220                           

gag gac gcc ggg gag tac acc tgc ctg gcg ggc aat tct att ggg ttt        720
Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe           
225                 230                 235                 240           

tct cat cac tct gcg tgg ctg gtg gtg ctg cca gcc gag gag gag ctg        768
Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu           
                245                 250                 255               

gtg gag gct gac gag gcg ggc agt gtg tat gca ggc gag ccc aaa tct        816
Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly Glu Pro Lys Ser           
            260                 265                 270                   

tca gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa gcc gag        864
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu           
        275                 280                 285                       

ggg gca ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc        912
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu           
    290                 295                 300                           

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc        960
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser           
305                 310                 315                 320           

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag       1008
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu           
                325                 330                 335               

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg       1056
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr           
            340                 345                 350                   

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat       1104
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn           
        355                 360                 365                       

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca tcc tcc       1152
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser           
    370                 375                 380                           

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag       1200
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln           
385                 390                 395                 400           

gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc       1248
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val           
                405                 410                 415               

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg       1296
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val           
            420                 425                 430                   

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct       1344
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro           
        435                 440                 445                       

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc       1392
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr           
    450                 455                 460                           

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg       1440
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val           
465                 470                 475                 480           

atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg       1488
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu           
                485                 490                 495               

tct ccg ggt ggt ggc ggg ggt tcg ggt gga gga ggt tct gaa gtt caa       1536
Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln           
            500                 505                 510                   

ttg tta gag tct ggt ggc ggt ctt gtt cag cct ggt ggt tct tta cgt       1584
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg           
        515                 520                 525                       

ctt tct tgc gct gct tcc gga ttc act ttc tct ggt tac att atg tgg       1632
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr Ile Met Trp           
    530                 535                 540                           

tgg gtt cgc caa gct cct ggt aaa ggt ttg gag tgg gtt tct gtt atc       1680
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile           
545                 550                 555                 560           

tct cct tct ggt ggc gat act tgg tat gct gac tcc gtt aaa ggt cgc       1728
Ser Pro Ser Gly Gly Asp Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg           
                565                 570                 575               

ttc act atc tct aga gac aac tct aag aat act ctc tac tta cag atg       1776
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met           
            580                 585                 590                   

aac agc tta agg gct gag gac acg gcc gtg tat tac tgt gcc aca gcg       1824
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Ala           
        595                 600                 605                       

gga gac tac tgg ggc cag ggc acc ctg gtc acc gtc tca agc ggt ggt       1872
Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly           
    610                 615                 620                           

ggt ggt tct ggc ggc ggc ggc tcc ggc ggg ggt gga agt ggt ggt ggt       1920
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly           
625                 630                 635                 640           

ggt tct ggt ggt ggt ggt tct cag agc gtg ttg act cag cca ccc tca       1968
Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser           
                645                 650                 655               

gcg tct ggg acc ccc ggg cag agg gtc acc atc tct tgt tct gga agc       2016
Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser           
            660                 665                 670                   

agc tcc aac atc gga agg aat cct gta aac tgg tac cag cag ctc cca       2064
Ser Ser Asn Ile Gly Arg Asn Pro Val Asn Trp Tyr Gln Gln Leu Pro           
        675                 680                 685                       

gga acg gcc ccc aaa ctc ctc atc tat ggt gat aat cag cgg ccc tca       2112
Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asp Asn Gln Arg Pro Ser           
    690                 695                 700                           

ggg gtc cct gac cga ttc tct ggc tcc aaa tct ggc acc tca gcc tcc       2160
Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser           
705                 710                 715                 720           

ctg gcc atc agt ggg ctc cag tct gag gat gag gct gat tat tac tgt       2208
Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys           
                725                 730                 735               

gca gca tgg gat gac agc ctg aat ggt gtg gta ttc ggc gga ggg acc       2256
Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val Phe Gly Gly Gly Thr           
            740                 745                 750                   

aag ctg acc gtc cta taa                                               2274
Lys Leu Thr Val Leu                                                       
        755                                                               


<210>  62
<211>  757
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  62

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Asp Thr Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg 
        35                  40                  45              


Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr 
    50                  55                  60                  


Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser 
65                  70                  75                  80  


Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly 
                85                  90                  95      


Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu Ser Val Val 
            100                 105                 110         


Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly 
        115                 120                 125             


Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu Arg Trp Pro His 
    130                 135                 140                 


Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu 
145                 150                 155                 160 


Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro 
                165                 170                 175     


His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly 
            180                 185                 190         


Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn 
        195                 200                 205             


Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His Asn Val Thr Phe 
    210                 215                 220                 


Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe 
225                 230                 235                 240 


Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu 
                245                 250                 255     


Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
            500                 505                 510         


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        515                 520                 525             


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr Ile Met Trp 
    530                 535                 540                 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile 
545                 550                 555                 560 


Ser Pro Ser Gly Gly Asp Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg 
                565                 570                 575     


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
            580                 585                 590         


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Ala 
        595                 600                 605             


Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
                645                 650                 655     


Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 
            660                 665                 670         


Ser Ser Asn Ile Gly Arg Asn Pro Val Asn Trp Tyr Gln Gln Leu Pro 
        675                 680                 685             


Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asp Asn Gln Arg Pro Ser 
    690                 695                 700                 


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
705                 710                 715                 720 


Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                725                 730                 735     


Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val Phe Gly Gly Gly Thr 
            740                 745                 750         


Lys Leu Thr Val Leu 
        755         


<210>  63
<211>  2634
<212>  DNA
<213>  Artificial

<220>
<223>  FGFR3(23-375)(S249W)Fc5 c870e6 pZMP31


<220>
<221>  CDS
<222>  (1)..(2634)

<400>  63
atg gat gca atg aag aga ggg ctc tgc tgt gtg ctg ctg ctg tgt ggc         48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly           
1               5                   10                  15                

gcc gtc ttc gtt tcg ctc agc cag gaa atc cat gcc gag ttg aga cgc         96
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg           
            20                  25                  30                    

ttc cgt aga gag tcc ttg ggg acg gag cag cgc gtc gtg ggg cga gcg        144
Phe Arg Arg Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala           
        35                  40                  45                        

gca gaa gtc ccg ggc cca gag ccc ggc cag cag gag cag ttg gtc ttc        192
Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe           
    50                  55                  60                            

ggc agc ggg gat gct gtg gag ctg agc tgt ccc ccg ccc ggg ggt ggt        240
Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly           
65                  70                  75                  80            

ccc atg ggg ccc act gtc tgg gtc aag gat ggc aca ggg ctg gtg ccc        288
Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro           
                85                  90                  95                

tcg gag cgt gtc ctg gtg ggg ccc cag cgg ctg cag gtg ctg aat gcc        336
Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala           
            100                 105                 110                   

tcc cac gag gac tcc ggg gcc tac agc tgc cgg cag cgg ctc acg cag        384
Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln           
        115                 120                 125                       

cgc gta ctg tgc cac ttc agt gtg cgg gtg aca gac gct cca tcc tcg        432
Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser           
    130                 135                 140                           

gga gat gac gaa gac ggg gag gac gag gct gag gac aca ggt gtg gac        480
Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp           
145                 150                 155                 160           

aca ggg gcc cct tac tgg aca cgg ccc gag cgg atg gac aag aag ctg        528
Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu           
                165                 170                 175               

ctg gcc gtg ccg gcc gcc aac acc gtc cgc ttc cgc tgc cca gcc gct        576
Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala           
            180                 185                 190                   

ggc aac ccc act ccc tcc atc tcc tgg ctg aag aac ggc agg gag ttc        624
Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe           
        195                 200                 205                       

cgc ggc gag cac cgc att gga ggc atc aag ctg cgg cat cag cag tgg        672
Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp           
    210                 215                 220                           

agc ctg gtc atg gaa agc gtg gtg ccc tcg gac cgc ggc aac tac acc        720
Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr           
225                 230                 235                 240           

tgc gtc gtg gag aac aag ttt ggc agc atc cgg cag acg tac acg ctg        768
Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu           
                245                 250                 255               

gac gtg ctg gag cgc tgg ccg cac cgg ccc atc ctg cag gcg ggg ctg        816
Asp Val Leu Glu Arg Trp Pro His Arg Pro Ile Leu Gln Ala Gly Leu           
            260                 265                 270                   

ccg gcc aac cag acg gcg gtg ctg ggc agc gac gtg gag ttc cac tgc        864
Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys           
        275                 280                 285                       

aag gtg tac agt gac gca cag ccc cac atc cag tgg ctc aag cac gtg        912
Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val           
    290                 295                 300                           

gag gtg aat ggc agc aag gtg ggc ccg gac ggc aca ccc tac gtt acc        960
Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr           
305                 310                 315                 320           

gtg ctc aag acg gcg ggc gct aac acc acc gac aag gag cta gag gtt       1008
Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val           
                325                 330                 335               

ctc tcc ttg cac aac gtc acc ttt gag gac gcc ggg gag tac acc tgc       1056
Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys           
            340                 345                 350                   

ctg gcg ggc aat tct att ggg ttt tct cat cac tct gcg tgg ctg gtg       1104
Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val           
        355                 360                 365                       

gtg ctg cca gcc gag gag gag ctg gtg gag gct gac gag gcg ggc agt       1152
Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser           
    370                 375                 380                           

gtg tat gca ggc gag ccc aaa tct tca gac aaa act cac aca tgc cca       1200
Val Tyr Ala Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro           
385                 390                 395                 400           

ccg tgc cca gca cct gaa gcc gag ggg gca ccg tca gtc ttc ctc ttc       1248
Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe           
                405                 410                 415               

ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc       1296
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val           
            420                 425                 430                   

aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc       1344
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe           
        435                 440                 445                       

aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg       1392
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro           
    450                 455                 460                           

cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc       1440
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr           
465                 470                 475                 480           

gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc       1488
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val           
                485                 490                 495               

tcc aac aaa gcc ctc cca tcc tcc atc gag aaa acc atc tcc aaa gcc       1536
Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala           
            500                 505                 510                   

aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg       1584
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg           
        515                 520                 525                       

gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc       1632
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly           
    530                 535                 540                           

ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg       1680
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro           
545                 550                 555                 560           

gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc       1728
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser           
                565                 570                 575               

ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag       1776
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln           
            580                 585                 590                   

ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac       1824
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His           
        595                 600                 605                       

tac acg cag aag agc ctc tcc ctg tct ccg ggt ggt ggc ggg ggt tcg       1872
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser           
    610                 615                 620                           

ggt gga gga ggt tct gaa gtt caa ttg tta gag tct ggt ggc ggt ctt       1920
Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu           
625                 630                 635                 640           

gtt cag cct ggt ggt tct tta cgt ctt tct tgc gct gct tcc gga ttc       1968
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe           
                645                 650                 655               

act ttc tct ggt tac att atg tgg tgg gtt cgc caa gct cct ggt aaa       2016
Thr Phe Ser Gly Tyr Ile Met Trp Trp Val Arg Gln Ala Pro Gly Lys           
            660                 665                 670                   

ggt ttg gag tgg gtt tct gtt atc tct cct tct ggt ggc gat act tgg       2064
Gly Leu Glu Trp Val Ser Val Ile Ser Pro Ser Gly Gly Asp Thr Trp           
        675                 680                 685                       

tat gct gac tcc gtt aaa ggt cgc ttc act atc tct aga gac aac tct       2112
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser           
    690                 695                 700                           

aag aat act ctc tac tta cag atg aac agc tta agg gct gag gac acg       2160
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr           
705                 710                 715                 720           

gcc gtg tat tac tgt gcc aca gcg gga gac tac tgg ggc cag ggc acc       2208
Ala Val Tyr Tyr Cys Ala Thr Ala Gly Asp Tyr Trp Gly Gln Gly Thr           
                725                 730                 735               

ctg gtc acc gtc tca agc ggt ggt ggt ggt tct ggc ggc ggc ggc tcc       2256
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser           
            740                 745                 750                   

ggc ggg ggt gga agt ggt ggt ggt ggt tct ggt ggt ggt ggt tct cag       2304
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln           
        755                 760                 765                       

agc gtg ttg act cag cca ccc tca gcg tct ggg acc ccc ggg cag agg       2352
Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg           
    770                 775                 780                           

gtc acc atc tct tgt tct gga agc agc tcc aac atc gga agg aat cct       2400
Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Pro           
785                 790                 795                 800           

gta aac tgg tac cag cag ctc cca gga acg gcc ccc aaa ctc ctc atc       2448
Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile           
                805                 810                 815               

tat ggt gat aat cag cgg ccc tca ggg gtc cct gac cga ttc tct ggc       2496
Tyr Gly Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly           
            820                 825                 830                   

tcc aaa tct ggc acc tca gcc tcc ctg gcc atc agt ggg ctc cag tct       2544
Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser           
        835                 840                 845                       

gag gat gag gct gat tat tac tgt gca gca tgg gat gac agc ctg aat       2592
Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn           
    850                 855                 860                           

ggt gtg gta ttc ggc gga ggg acc aag ctg acc gtc cta taa               2634
Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                       
865                 870                 875                               


<210>  64
<211>  877
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  64

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala 
        35                  40                  45              


Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe 
    50                  55                  60                  


Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly 
65                  70                  75                  80  


Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro 
                85                  90                  95      


Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala 
            100                 105                 110         


Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln 
        115                 120                 125             


Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser 
    130                 135                 140                 


Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp 
145                 150                 155                 160 


Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu 
                165                 170                 175     


Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala 
            180                 185                 190         


Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe 
        195                 200                 205             


Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp 
    210                 215                 220                 


Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr 
225                 230                 235                 240 


Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu 
                245                 250                 255     


Asp Val Leu Glu Arg Trp Pro His Arg Pro Ile Leu Gln Ala Gly Leu 
            260                 265                 270         


Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys 
        275                 280                 285             


Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val 
    290                 295                 300                 


Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr 
305                 310                 315                 320 


Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val 
                325                 330                 335     


Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys 
            340                 345                 350         


Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val 
        355                 360                 365             


Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser 
    370                 375                 380                 


Val Tyr Ala Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
385                 390                 395                 400 


Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 
                405                 410                 415     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            420                 425                 430         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        435                 440                 445             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    450                 455                 460                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
465                 470                 475                 480 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                485                 490                 495     


Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            500                 505                 510         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        515                 520                 525             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    530                 535                 540                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
545                 550                 555                 560 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                565                 570                 575     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            580                 585                 590         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        595                 600                 605             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
625                 630                 635                 640 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                645                 650                 655     


Thr Phe Ser Gly Tyr Ile Met Trp Trp Val Arg Gln Ala Pro Gly Lys 
            660                 665                 670         


Gly Leu Glu Trp Val Ser Val Ile Ser Pro Ser Gly Gly Asp Thr Trp 
        675                 680                 685             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    690                 695                 700                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
705                 710                 715                 720 


Ala Val Tyr Tyr Cys Ala Thr Ala Gly Asp Tyr Trp Gly Gln Gly Thr 
                725                 730                 735     


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        755                 760                 765             


Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg 
    770                 775                 780                 


Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Pro 
785                 790                 795                 800 


Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
                805                 810                 815     


Tyr Gly Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 
            820                 825                 830         


Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser 
        835                 840                 845             


Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn 
    850                 855                 860                 


Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
865                 870                 875         


<210>  65
<211>  322
<212>  DNA
<213>  Homo sapien

<400>  65
aacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag      300

gggaccaagc tggagatcaa ac                                               322


<210>  66
<211>  107
<212>  PRT
<213>  Homo sapien

<400>  66

Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  67
<211>  364
<212>  DNA
<213>  Homo sapien

<400>  67
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct tggtacgata tggtttgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctgtt atctctcctt ctggtggctg gacttcttat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagatcat      300

agtggctacg attctgaata ctttgactac tggggccagg gcaccctggt caccgtctca      360

agcg                                                                   364


<210>  68
<211>  121
<212>  PRT
<213>  Homo sapien

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Asp Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ser Gly Gly Trp Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Ser Gly Tyr Asp Ser Glu Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  69
<211>  759
<212>  DNA
<213>  ArtificiaL

<220>
<223>  c1039.1 scFv cDNA

<400>  69
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct tggtacgata tggtttgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctgtt atctctcctt ctggtggctg gacttcttat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagatcat      300

agtggctacg attctgaata ctttgactac tggggccagg gcaccctggt caccgtctca      360

agcggtggtg gtggttctgg cggcggcggc tccggcgggg gtggaagtgg tggtggtggt      420

tctggtggtg gtggttctaa catccagatg acccagtctc catcctccct gtctgcatct      480

gtaggagaca gagtcaccat cacttgccgg gcaagtcaga gcattagcag ctatttaaat      540

tggtatcagc agaaaccagg gaaagcccct aagctcctga tctatgctgc atccagtttg      600

caaagtgggg tcccatcaag gttcagtggc agtggatctg ggacagattt cactctcacc      660

atcagcagtc tgcaacctga agattttgca acttactact gtcaacagag ttacagtacc      720

ccgtacactt ttggccaggg gaccaagctg gagatcaaa                             759


<210>  70
<211>  253
<212>  PRT
<213>  Artificial

<220>
<223>  c1039.1 scFv

<400>  70

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Asp Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ser Gly Gly Trp Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Ser Gly Tyr Asp Ser Glu Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250             


<210>  71
<211>  990
<212>  DNA
<213>  Homo sapien


<220>
<221>  CDS
<222>  (1)..(990)

<400>  71
cag tgt gct ggc ggc ccg gcg cga gcc ggc ccg gcc ccg gtc ggg cct         48
Gln Cys Ala Gly Gly Pro Ala Arg Ala Gly Pro Ala Pro Val Gly Pro           
1               5                   10                  15                

ccg aaa cca tga act ttc tgc tgt ctt ggg tgc att gga gcc tcg cct         96
Pro Lys Pro     Thr Phe Cys Cys Leu Gly Cys Ile Gly Ala Ser Pro           
                20                  25                  30                

tgc tgc tct acc tcc acc atg cca agt ggt ccc agg ctg cac cca tgg        144
Cys Cys Ser Thr Ser Thr Met Pro Ser Gly Pro Arg Leu His Pro Trp           
            35                  40                  45                    

cag aag gag gag ggc aga atc atc acg aag tgg tga agt tca tgg atg        192
Gln Lys Glu Glu Gly Arg Ile Ile Thr Lys Trp     Ser Ser Trp Met           
        50                  55                      60                    

tct atc agc gca gct act gcc atc caa tcg aga ccc tgg tgg aca tct        240
Ser Ile Ser Ala Ala Thr Ala Ile Gln Ser Arg Pro Trp Trp Thr Ser           
        65                  70                  75                        

tcc agg agt acc ctg atg aga tcg agt aca tct tca agc cat cct gtg        288
Ser Arg Ser Thr Leu Met Arg Ser Ser Thr Ser Ser Ser His Pro Val           
    80                  85                  90                            

tgc ccc tga tgc gat gcg ggg gct gct gca atg acg agg gcc tgg agt        336
Cys Pro     Cys Asp Ala Gly Ala Ala Ala Met Thr Arg Ala Trp Ser           
95                      100                 105                           

gtg tgc cca ctg agg agt cca aca tca cca tgc aga tta tgc gga tca        384
Val Cys Pro Leu Arg Ser Pro Thr Ser Pro Cys Arg Leu Cys Gly Ser           
110                 115                 120                 125           

aac ctc acc aag gcc agc aca tag gag aga tga gct tcc tac agc aca        432
Asn Leu Thr Lys Ala Ser Thr     Glu Arg     Ala Ser Tyr Ser Thr           
                130                         135                           

aca aat gtg aat gca gac caa aga aag ata gag caa gac aag aaa atc        480
Thr Asn Val Asn Ala Asp Gln Arg Lys Ile Glu Gln Asp Lys Lys Ile           
140                 145                 150                 155           

cct gtg ggc ctt gct cag agc gga gaa agc att tgt ttg tac aag atc        528
Pro Val Gly Leu Ala Gln Ser Gly Glu Ser Ile Cys Leu Tyr Lys Ile           
                160                 165                 170               

cgc aga cgt gta aat gtt cct gca aaa aca cag act cgc gtt gca agg        576
Arg Arg Arg Val Asn Val Pro Ala Lys Thr Gln Thr Arg Val Ala Arg           
            175                 180                 185                   

cga ggc agc ttg agt taa acg aac gta ctt gca gat gtg aca agc cga        624
Arg Gly Ser Leu Ser     Thr Asn Val Leu Ala Asp Val Thr Ser Arg           
        190                     195                 200                   

ggc ggt gag ccg ggc agg agg aag gag cct ccc tca ggg ttt cgg gaa        672
Gly Gly Glu Pro Gly Arg Arg Lys Glu Pro Pro Ser Gly Phe Arg Glu           
        205                 210                 215                       

cca gat ctc tca cca gga aag act gat aca gaa cga tcg ata cag aaa        720
Pro Asp Leu Ser Pro Gly Lys Thr Asp Thr Glu Arg Ser Ile Gln Lys           
    220                 225                 230                           

cca cgc tgc cgc cac cac acc atc acc atc gac aga aca gtc ctt aat        768
Pro Arg Cys Arg His His Thr Ile Thr Ile Asp Arg Thr Val Leu Asn           
235                 240                 245                 250           

cca gaa acc tga aat gaa gga aga gga gac tct gcg cag agc act ttg        816
Pro Glu Thr     Asn Glu Gly Arg Gly Asp Ser Ala Gln Ser Thr Leu           
                    255                 260                 265           

ggt ccg gag ggc gag act ccg gcg gaa gca ttc ccg ggc ggg tga ccc        864
Gly Pro Glu Gly Glu Thr Pro Ala Glu Ala Phe Pro Gly Gly     Pro           
                270                 275                     280           

agc acg gtc cct ctt gga att gga ttc gcc att tta ttt ttc ttg ctg        912
Ser Thr Val Pro Leu Gly Ile Gly Phe Ala Ile Leu Phe Phe Leu Leu           
                285                 290                 295               

cta aat cac cga gcc cgg aag att aga gag ttt tat ttc tgg gat tcc        960
Leu Asn His Arg Ala Arg Lys Ile Arg Glu Phe Tyr Phe Trp Asp Ser           
            300                 305                 310                   

tgt aga cac acc gcg gcc gcc agc aca ctg                                990
Cys Arg His Thr Ala Ala Ala Ser Thr Leu                                   
        315                 320                                           


<210>  72
<211>  19
<212>  PRT
<213>  Homo sapien

<400>  72

Gln Cys Ala Gly Gly Pro Ala Arg Ala Gly Pro Ala Pro Val Gly Pro 
1               5                   10                  15      


Pro Lys Pro 
            


<210>  73
<211>  39
<212>  PRT
<213>  Homo sapien

<400>  73

Thr Phe Cys Cys Leu Gly Cys Ile Gly Ala Ser Pro Cys Cys Ser Thr 
1               5                   10                  15      


Ser Thr Met Pro Ser Gly Pro Arg Leu His Pro Trp Gln Lys Glu Glu 
            20                  25                  30          


Gly Arg Ile Ile Thr Lys Trp 
        35                  


<210>  74
<211>  38
<212>  PRT
<213>  Homo sapien

<400>  74

Ser Ser Trp Met Ser Ile Ser Ala Ala Thr Ala Ile Gln Ser Arg Pro 
1               5                   10                  15      


Trp Trp Thr Ser Ser Arg Ser Thr Leu Met Arg Ser Ser Thr Ser Ser 
            20                  25                  30          


Ser His Pro Val Cys Pro 
        35              


<210>  75
<211>  36
<212>  PRT
<213>  Homo sapien

<400>  75

Cys Asp Ala Gly Ala Ala Ala Met Thr Arg Ala Trp Ser Val Cys Pro 
1               5                   10                  15      


Leu Arg Ser Pro Thr Ser Pro Cys Arg Leu Cys Gly Ser Asn Leu Thr 
            20                  25                  30          


Lys Ala Ser Thr 
        35      


<210>  76
<211>  58
<212>  PRT
<213>  Homo sapien

<400>  76

Ala Ser Tyr Ser Thr Thr Asn Val Asn Ala Asp Gln Arg Lys Ile Glu 
1               5                   10                  15      


Gln Asp Lys Lys Ile Pro Val Gly Leu Ala Gln Ser Gly Glu Ser Ile 
            20                  25                  30          


Cys Leu Tyr Lys Ile Arg Arg Arg Val Asn Val Pro Ala Lys Thr Gln 
        35                  40                  45              


Thr Arg Val Ala Arg Arg Gly Ser Leu Ser 
    50                  55              


<210>  77
<211>  61
<212>  PRT
<213>  Homo sapien

<400>  77

Thr Asn Val Leu Ala Asp Val Thr Ser Arg Gly Gly Glu Pro Gly Arg 
1               5                   10                  15      


Arg Lys Glu Pro Pro Ser Gly Phe Arg Glu Pro Asp Leu Ser Pro Gly 
            20                  25                  30          


Lys Thr Asp Thr Glu Arg Ser Ile Gln Lys Pro Arg Cys Arg His His 
        35                  40                  45              


Thr Ile Thr Ile Asp Arg Thr Val Leu Asn Pro Glu Thr 
    50                  55                  60      


<210>  78
<211>  26
<212>  PRT
<213>  Homo sapien

<400>  78

Asn Glu Gly Arg Gly Asp Ser Ala Gln Ser Thr Leu Gly Pro Glu Gly 
1               5                   10                  15      


Glu Thr Pro Ala Glu Ala Phe Pro Gly Gly 
            20                  25      


<210>  79
<211>  43
<212>  PRT
<213>  Homo sapien

<400>  79

Pro Ser Thr Val Pro Leu Gly Ile Gly Phe Ala Ile Leu Phe Phe Leu 
1               5                   10                  15      


Leu Leu Asn His Arg Ala Arg Lys Ile Arg Glu Phe Tyr Phe Trp Asp 
            20                  25                  30          


Ser Cys Arg His Thr Ala Ala Ala Ser Thr Leu 
        35                  40              


<210>  80
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  peptide linker

<400>  80

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  81
<211>  232
<212>  PRT
<213>  Homo sapien

<400>  81

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  82
<211>  232
<212>  PRT
<213>  Homo sapien

<400>  82

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  83
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  Fc-488

<400>  83

Glu Pro Arg Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  84
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  Fc-4

<400>  84

Glu Pro Arg Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  85
<211>  231
<212>  PRT
<213>  Artificial

<220>
<223>  Fc6

<400>  85

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  86
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  FC7

<400>  86

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Glu Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  87
<211>  339
<212>  PRT
<213>  Homo sapien

<400>  87

Arg Asp Glu Ser Asn His Leu Thr Asp Leu Tyr Arg Arg Asp Glu Thr 
1               5                   10                  15      


Ile Gln Val Lys Gly Asn Gly Tyr Val Gln Ser Pro Arg Phe Pro Asn 
            20                  25                  30          


Ser Tyr Pro Arg Asn Leu Leu Leu Thr Trp Arg Leu His Ser Gln Glu 
        35                  40                  45              


Asn Thr Arg Ile Gln Leu Val Phe Asp Asn Gln Phe Gly Leu Glu Glu 
    50                  55                  60                  


Ala Glu Asn Asp Ile Cys Arg Tyr Asp Phe Val Glu Val Glu Asp Ile 
65                  70                  75                  80  


Ser Glu Thr Ser Thr Ile Ile Arg Gly Arg Trp Cys Gly His Lys Glu 
                85                  90                  95      


Val Pro Pro Arg Ile Lys Ser Arg Thr Asn Gln Ile Lys Ile Thr Phe 
            100                 105                 110         


Lys Ser Asp Asp Tyr Phe Val Ala Lys Pro Gly Phe Lys Ile Tyr Tyr 
        115                 120                 125             


Ser Leu Leu Glu Asp Phe Gln Pro Ala Ala Ala Ser Glu Thr Asn Trp 
    130                 135                 140                 


Glu Ser Val Thr Ser Ser Ile Ser Gly Val Ser Tyr Asn Ser Pro Ser 
145                 150                 155                 160 


Val Thr Asp Pro Thr Leu Ile Ala Asp Ala Leu Asp Lys Lys Ile Ala 
                165                 170                 175     


Glu Phe Asp Thr Val Glu Asp Leu Leu Lys Tyr Phe Asn Pro Glu Ser 
            180                 185                 190         


Trp Gln Glu Asp Leu Glu Asn Met Tyr Leu Asp Thr Pro Arg Tyr Arg 
        195                 200                 205             


Gly Arg Ser Tyr His Asp Arg Lys Ser Lys Val Asp Leu Asp Arg Leu 
    210                 215                 220                 


Asn Asp Asp Ala Lys Arg Tyr Ser Cys Thr Pro Arg Asn Tyr Ser Val 
225                 230                 235                 240 


Asn Ile Arg Glu Glu Leu Lys Leu Ala Asn Val Val Phe Phe Pro Arg 
                245                 250                 255     


Cys Leu Leu Val Gln Arg Cys Gly Gly Asn Cys Gly Cys Gly Thr Val 
            260                 265                 270         


Asn Trp Arg Ser Cys Thr Cys Asn Ser Gly Lys Thr Val Lys Lys Tyr 
        275                 280                 285             


His Glu Val Leu Gln Phe Glu Pro Gly His Ile Lys Arg Arg Gly Arg 
    290                 295                 300                 


Ala Lys Thr Met Ala Leu Val Asp Ile Gln Leu Asp His His Glu Arg 
305                 310                 315                 320 


Cys Asp Cys Ile Cys Ser Ser Arg Pro Pro Arg Tyr Leu Glu Tyr Met 
                325                 330                 335     


Pro Met Asp 
            


<210>  88
<211>  1002
<212>  PRT
<213>  Artificial

<220>
<223>  VEGFR2-Fc

<400>  88

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser His Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Gly Ser Gly Gly 
        755                 760                 765             


Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    770                 775                 780                 


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
785                 790                 795                 800 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                805                 810                 815     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            820                 825                 830         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        835                 840                 845             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    850                 855                 860                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
865                 870                 875                 880 


Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                885                 890                 895     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            900                 905                 910         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        915                 920                 925             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    930                 935                 940                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
945                 950                 955                 960 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                965                 970                 975     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            980                 985                 990         


Gln Lys Ser Leu Ser Leu Ser Pro  Gly Lys 
        995                 1000         


<210>  89
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  zc60566

<400>  89
agaacctcct ccacccgaac ccccgccacc acccggagac agggagag                    48


