                         SEQUENCE LISTING

<110>  Shah, Jyoti
       Strapps, Walter
       Pickering, Victoria
 
<120>  RNA Interference Mediated Inhibition of the Intercellular 
       Adhesion Molecule 1 (ICAM-1) Gene Expression Using Short 
       Interfering Nucleic Acid (siNA)

<130>  SIRMIS84WPCT

<160>  160   

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
cagugacugu cacucgaga                                                    19


<210>  2
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
cgcaucugau cuguaguca                                                    19


<210>  3
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
cucagcacgu accucuaua                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
cucagucagu gugaccgca                                                    19


<210>  5
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
ggaacaaccg gaaggugua                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
cggaagauca agaaauaca                                                    19


<210>  7
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
cauuguccuc agucagaua                                                    19


<210>  8
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
ggagcaagac ucaagacau                                                    19


<210>  9
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
cagacaguga ccaucuaca                                                    19


<210>  10
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
gaucuguagu cacaugacu                                                    19


<210>  11
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
gccaauuucu cgugccgca                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
gcucaggagg aggccauaa                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
agaaagauca ggauauaca                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
gcuggcauug uucucuaau                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
gcuggcauug uucucuaau                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
aguacuguac cacucucaa                                                    19


<210>  17
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
aguacuguac cacucucaa                                                    19


<210>  18
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
ccguguauuc guuuccgga                                                    19


<210>  19
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
cguguauucg uuuccggag                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
aggaccuuaa cagucuaca                                                    19


<210>  21
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
gcuuggagac ucaguggcu                                                    19


<210>  22
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
acucaguggc ugaaagaug                                                    19


<210>  23
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
acagcauuua cccucagcc                                                    19


<210>  24
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
ggaccuuaac agucuacaa                                                    19


<210>  25
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
ccucgugaug gcagccucu                                                    19


<210>  26
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
cgugauggca gccucuuau                                                    19


<210>  27
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
ugauggcagc cucuuaugu                                                    19


<210>  28
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
ggacuuucga ucuuccagc                                                    19


<210>  29
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
gggucgaagg ugguucuuc                                                    19


<210>  30
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
acuuguagcc ucagagcua                                                    19


<210>  31
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
gcagucgucc gcuuccgcu                                                    19


<210>  32
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
ggugacugag gaguucgac                                                    19


<210>  33
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
cucuuccucg gccuuccca                                                    19


<210>  34
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
cagugaccau cuacagcuu                                                    19


<210>  35
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
gugucuaaag gauggcacu                                                    19


<210>  36
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
guugcuccug ccugggaac                                                    19


<210>  37
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
gacauacaac ugggaaaua                                                    19


<210>  38
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
cuggcaaugc ccagacauc                                                    19


<210>  39
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
cugagcaaug ugcaagaag                                                    19


<210>  40
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
cagucagugu gaccgcaga                                                    19


<210>  41
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
gagacacugc agacaguga                                                    19


<210>  42
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
gggauugucc gggaaacug                                                    19


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  43
cagugacugu cacucgagat t                                                 21


<210>  44
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  44
ucucgaguga cagucacugu u                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  45
cgcaucugau cuguagucat t                                                 21


<210>  46
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  46
ugacuacaga ucagaugcgu u                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  47
cucagcacgu accucuauat t                                                 21


<210>  48
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  2'-O-methyl

<400>  48
uauagaggua cgugcugagu u                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  49
cucagucagu gugaccgcat t                                                 21


<210>  50
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  2'-O-methyl

<400>  50
ugcggucaca cugacugagu u                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  51
ggaacaaccg gaagguguat t                                                 21


<210>  52
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  52
uacaccuucc gguuguuccu u                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  53
cggaagauca agaaauacat t                                                 21


<210>  54
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  54
uguauuucuu gaucuuccgu u                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  55
cauuguccuc agucagauat t                                                 21


<210>  56
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  56
uaucugacug aggacaaugu u                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  57
ggagcaagac ucaagacaut t                                                 21


<210>  58
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  58
augucuugag ucuugcuccu u                                                 21


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  59
cagacaguga ccaucuacat t                                                 21


<210>  60
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  60
uguagauggu cacugucugu u                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  61
gaucuguagu cacaugacut t                                                 21


<210>  62
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  62
agucauguga cuacagaucu u                                                 21


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  63
gccaauuucu cgugccgcat t                                                 21


<210>  64
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  64
ugcggcacga gaaauuggcu u                                                 21


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  65
gcucaggagg aggccauaat t                                                 21


<210>  66
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  66
uuauggccuc cuccugagcu u                                                 21


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  67
agaaagauca ggauauacat t                                                 21


<210>  68
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  68
uguauauccu gaucuuucuu u                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  69
gcuggcauug uucucuaaut t                                                 21


<210>  70
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  70
auuagagaac aaugccagcu u                                                 21


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  71
ugccaguacu gcuggucaut t                                                 21


<210>  72
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  72
augaccagca guacuggcau u                                                 21


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  73
aguacuguac cacucucaat t                                                 21


<210>  74
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  74
uugagagugg uacaguacuu u                                                 21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  75
accuuaacag ucuacaacut t                                                 21


<210>  76
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  76
aguuguagac uguuaagguu u                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  77
ccguguauuc guuuccggat t                                                 21


<210>  78
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  78
uccggaaacg aauacacggu u                                                 21


<210>  79
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  79
cguguauucg uuuccggagt t                                                 21


<210>  80
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  80
cuccggaaac gaauacacgu u                                                 21


<210>  81
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  81
aggaccuuaa cagucuacat t                                                 21


<210>  82
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  82
uguagacugu uaagguccuu u                                                 21


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  83
gcuuggagac ucaguggcut t                                                 21


<210>  84
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  84
agccacugag ucuccaagcu u                                                 21


<210>  85
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  85
acucaguggc ugaaagaugt t                                                 21


<210>  86
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  86
caucuuucag ccacugaguu u                                                 21


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  87
acagcauuua cccucagcct t                                                 21


<210>  88
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  88
ggcugagggu aaaugcuguu u                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  89
ggaccuuaac agucuacaat t                                                 21


<210>  90
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  90
uuguagacug uuaagguccu u                                                 21


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  91
ccucgugaug gcagccucut t                                                 21


<210>  92
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  2'-O-methyl

<400>  92
agaggcugcc aucacgaggu u                                                 21


<210>  93
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  93
cgugauggca gccucuuaut t                                                 21


<210>  94
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  94
auaagaggcu gccaucacgu u                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  95
ugauggcagc cucuuaugut t                                                 21


<210>  96
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  96
acauaagagg cugccaucau u                                                 21


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  97
ggacuuucga ucuuccagct t                                                 21


<210>  98
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  98
gcuggaagau cgaaaguccu u                                                 21


<210>  99
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  99
gggucgaagg ugguucuuct t                                                 21


<210>  100
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  100
gaagaaccac cuucgacccu u                                                 21


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  101
acuuguagcc ucagagcuat t                                                 21


<210>  102
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  102
uagcucugag gcuacaaguu u                                                 21


<210>  103
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  103
gcagucgucc gcuuccgcut t                                                 21


<210>  104
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  104
agcggaagcg gacgacugcu u                                                 21


<210>  105
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  105
ggugacugag gaguucgact t                                                 21


<210>  106
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  106
gucgaacucc ucagucaccu u                                                 21


<210>  107
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  107
cucuuccucg gccuucccat t                                                 21


<210>  108
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(21)
<223>  2'-O-methyl

<400>  108
ugggaaggcc gaggaagagu u                                                 21


<210>  109
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  109
cagugaccau cuacagcuut t                                                 21


<210>  110
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  110
aagcuguaga uggucacugu u                                                 21


<210>  111
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  111
gugucuaaag gauggcacut t                                                 21


<210>  112
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  112
agugccaucc uuuagacacu u                                                 21


<210>  113
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  113
guugcuccug ccugggaact t                                                 21


<210>  114
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  114
guucccaggc aggagcaacu u                                                 21


<210>  115
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  115
gacauacaac ugggaaauat t                                                 21


<210>  116
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  116
uauuucccag uuguaugucu u                                                 21


<210>  117
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  117
cuggcaaugc ccagacauct t                                                 21


<210>  118
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  118
gaugucuggg cauugccagu u                                                 21


<210>  119
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  119
cugagcaaug ugcaagaagt t                                                 21


<210>  120
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  120
cuucuugcac auugcucacu u                                                 21


<210>  121
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  121
cagucagugu gaccgcagat t                                                 21


<210>  122
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  122
ucugcgguca cacugacugu u                                                 21


<210>  123
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  123
gagacacugc agacagugat t                                                 21


<210>  124
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  124
ucacugucug cagugucucu u                                                 21


<210>  125
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  125
gggauugucc gggaaacugt t                                                 21


<210>  126
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  126
caguuucccg gacaaucccu u                                                 21


<210>  127
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modifed as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  127
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  128
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  128
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  129
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl and any purine is 2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<400>  129
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  130
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl and any purine is 2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  130
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  131
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  131
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  132
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  132
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  133
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl and any purine is 2'-deoxy

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  133
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  134
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl and any purine is 2'-deoxy

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  134
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  135
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  135
cgcaucugau cuguagucan n                                                 21


<210>  136
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  136
ugacuacaga ucagaugcgn n                                                 21


<210>  137
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  137
cgcaucugau cuguagucan n                                                 21


<210>  138
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  138
ugacuacaga ucagaugcgn n                                                 21


<210>  139
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  139
cgcaucugau cuguagucan n                                                 21


<210>  140
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  140
ugacuacaga ucagaugcgn n                                                 21


<210>  141
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  141
cgcaucugau cuguagucan n                                                 21


<210>  142
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  142
ugacuacaga ucagaugcgn n                                                 21


<210>  143
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  143
ugacuacaga ucagaugcg                                                    19


<210>  144
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  144
ugcggucaca cugacugag                                                    19


<210>  145
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145
uacaccuucc gguuguucc                                                    19


<210>  146
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146
uguauuucuu gaucuuccg                                                    19


<210>  147
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  147
uaucugacug aggacaaug                                                    19


<210>  148
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  148
uauuucccag uuguauguc                                                    19


<210>  149
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  149
ugcggcacga gaaauuggc                                                    19


<210>  150
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  150
gaugucuggg cauugccag                                                    19


<210>  151
<211>  3249
<212>  RNA
<213>  Homo sapiens

<400>  151
caagcuuagc cuggccggga aacgggaggc guggaggccg ggagcagccc ccggggucau       60

cgcccugcca ccgccgcccg auugcuuuag cuuggaaauu ccggagcuga agcggccagc      120

gagggaggau gacccucucg gcccgggcac ccugucaguc cggaaauaac ugcagcauuu      180

guuccggagg ggaaggcgcg agguuuccgg gaaagcagca ccgccccuug gcccccaggu      240

ggcuagcgcu auaaaggauc acgcgcccca gucgacgcug agcuccucug cuacucagag      300

uugcaaccuc agccucgcua uggcucccag cagcccccgg cccgcgcugc ccgcacuccu      360

gguccugcuc ggggcucugu ucccaggacc uggcaaugcc cagacaucug ugucccccuc      420

aaaagucauc cugccccggg gaggcuccgu gcuggugaca ugcagcaccu ccugugacca      480

gcccaaguug uugggcauag agaccccguu gccuaaaaag gaguugcucc ugccugggaa      540

caaccggaag guguaugaac ugagcaaugu gcaagaagau agccaaccaa ugugcuauuc      600

aaacugcccu gaugggcagu caacagcuaa aaccuuccuc accguguacu ggacuccaga      660

acggguggaa cuggcacccc uccccucuug gcagccagug ggcaagaacc uuacccuacg      720

cugccaggug gagggugggg caccccgggc caaccucacc guggugcugc uccgugggga      780

gaaggagcug aaacgggagc cagcuguggg ggagcccgcu gaggucacga ccacggugcu      840

ggugaggaga gaucaccaug gagccaauuu cucgugccgc acugaacugg accugcggcc      900

ccaagggcug gagcuguuug agaacaccuc ggcccccuac cagcuccaga ccuuuguccu      960

gccagcgacu cccccacaac uugucagccc ccggguccua gagguggaca cgcaggggac     1020

cguggucugu ucccuggacg ggcuguuccc agucucggag gcccaggucc accuggcacu     1080

gggggaccag agguugaacc ccacagucac cuauggcaac gacuccuucu cggccaaggc     1140

cucagucagu gugaccgcag aggacgaggg cacccagcgg cugacgugug caguaauacu     1200

ggggaaccag agccaggaga cacugcagac agugaccauc uacagcuuuc cggcgcccaa     1260

cgugauucug acgaagccag aggucucaga agggaccgag gugacaguga agugugaggc     1320

ccacccuaga gccaagguga cgcugaaugg gguuccagcc cagccacugg gcccgagggc     1380

ccagcuccug cugaaggcca ccccagagga caacgggcgc agcuucuccu gcucugcaac     1440

ccuggaggug gccggccagc uuauacacaa gaaccagacc cgggagcuuc guguccugua     1500

uggcccccga cuggacgaga gggauugucc gggaaacugg acguggccag aaaauuccca     1560

gcagacucca augugccagg cuugggggaa cccauugccc gagcucaagu gucuaaagga     1620

uggcacuuuc ccacugccca ucggggaauc agugacuguc acucgagauc uugagggcac     1680

cuaccucugu cgggccagga gcacucaagg ggaggucacc cgcaagguga ccgugaaugu     1740

gcucuccccc cgguaugaga uugucaucau cacuguggua gcagccgcag ucauaauggg     1800

cacugcaggc cucagcacgu accucuauaa ccgccagcgg aagaucaaga aauacagacu     1860

acaacaggcc caaaaaggga cccccaugaa accgaacaca caagccacgc cucccugaac     1920

cuaucccggg acagggccuc uuccucggcc uucccauauu gguggcagug gugccacacu     1980

gaacagagug gaagacauau gccaugcagc uacaccuacc ggcccuggga cgccggagga     2040

cagggcauug uccucaguca gauacaacag cauuuggggc caugguaccu gcacaccuaa     2100

aacacuaggc cacgcaucug aucuguaguc acaugacuaa gccaagagga aggagcaaga     2160

cucaagacau gauugaugga uguuaaaguc uagccugaug agaggggaag ugguggggga     2220

gacauagccc caccaugagg acauacaacu gggaaauacu gaaacuugcu gccuauuggg     2280

uaugcugagg ccccacagac uuacagaaga aguggcccuc cauagacaug uguagcauca     2340

aaacacaaag gcccacacuu ccugacggau gccagcuugg gcacugcugu cuacugaccc     2400

caacccuuga ugauauguau uuauucauuu guuauuuuac cagcuauuua uugagugucu     2460

uuuauguagg cuaaaugaac auaggucucu ggccucacgg agcucccagu ccuaaucaca     2520

uucaagguca ccagguacag uuguacaggu uguacacugc aggagagugc cuggcaaaaa     2580

gaucaaaugg ggcugggacu ucucauuggc caaccugccu uuccccagaa ggagugauuu     2640

uucuaucggc acaaaagcac uauauggacu gguaaugguu acagguucag agauuaccca     2700

gugaggccuu auuccucccu uccccccaaa acugacaccu uuguuagcca ccuccccacc     2760

cacauacauu ucugccagug uucacaauga cacucagcgg ucaugucugg acaugagugc     2820

ccagggaaua ugcccaagcu augccuuguc cucuuguccu guuugcauuu cacugggagc     2880

uugcacuaug cagcuccagu uuccugcagu gaucaggguc cugcaagcag uggggaaggg     2940

ggccaaggua uuggaggacu cccucccagc uuuggaagcc ucauccgcgu gugugugugu     3000

guguaugugu agacaagcuc ucgcucuguc acccaggcug gagugcagug gugcaaucau     3060

gguucacugc agucuugacc uuuugggcuc aagugauccu cccaccucag ccuccugagu     3120

agcugggacc auaggcucac aacaccacac cuggcaaauu ugauuuuuuu uuuuuuucca     3180

gagacggggu cucgcaacau ugcccagacu uccuuugugu uaguuaauaa agcuuucuca     3240

acugccaaa                                                             3249



<210>  152
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  152
caaggtcatc catgacaact ttg                                               23


<210>  153
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  153
gggccatcca cagtcttct                                                    19


<210>  154
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  154
accacagtcc atgccatcac tgcca                                             25


<210>  155
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  155
gctctgcaac cctggaggt                                                    19


<210>  156
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  156
ggccatacag gacacgaagc                                                   20


<210>  157
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  157
ccagcttata cacaagaacc agacccgg                                          28


<210>  158
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  158
acctaacccc caaatctatg tcaa                                              24


<210>  159
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  159
tggagaactc gccctctttc                                                   20


<210>  160
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  160
ctcatcgagg agtgcaccga cctg                                              24





