                         SEQUENCE LISTING

<110>  DICKEY, BURTON
       TUVIM, MICHAEL
       EVANS, SCOTT
 
<120>  COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE 
       RESISTANCE TO PATHOGENS

<130>  TAMK:252WO

<140>  UNKNOWN
<141>  2010-03-25

<150>  61/163,137
<151>  2009-03-25

<150>  61/179,246
<151>  2009-05-18

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1651
<212>  PRT
<213>  Enterococcus faecalis

<400>  1

Met Lys Lys Lys Thr Phe Ser Phe Val Met Leu Ser Ile Leu Leu Ala 
1               5                   10                  15      


Gln Asn Phe Gly Phe Ala Val Asn Ala Tyr Ala Val Thr Thr Thr Glu 
            20                  25                  30          


Ala Gln Thr Glu Thr Thr Asp Thr Ala Lys Lys Glu Ala Glu Leu Ser 
        35                  40                  45              


Asn Ser Thr Pro Ser Leu Pro Leu Ala Thr Thr Thr Thr Ser Glu Met 
    50                  55                  60                  


Asn Gln Pro Thr Ala Thr Thr Glu Ser Gln Thr Thr Glu Ala Ser Thr 
65                  70                  75                  80  


Thr Ala Ser Ser Asp Ala Ala Thr Pro Ser Glu Gln Gln Thr Thr Glu 
                85                  90                  95      


Asp Lys Asp Thr Ser Leu Asn Glu Lys Ala Leu Pro Asp Val Gln Ala 
            100                 105                 110         


Pro Ile Thr Asp Glu Leu Leu Asp Ser Met Ser Leu Ala Pro Ile Gly 
        115                 120                 125             


Gly Thr Glu Tyr Ser Gln Thr Glu Val His Arg Glu Leu Asn Thr Thr 
    130                 135                 140                 


Pro Val Thr Ala Thr Phe Gln Phe Ala Val Gly Asn Thr Gly Tyr Ala 
145                 150                 155                 160 


Pro Gly Ser Val Tyr Thr Val Gln Leu Pro Glu His Leu Gly Tyr Ser 
                165                 170                 175     


Thr Val Ser Gly Glu Val Thr Gly Ile Gly Ala Thr Trp Ala Val Asp 
            180                 185                 190         


Ala Ala Thr Lys Thr Leu Ser Ile Thr Phe Asn Gln Arg Val Ser Asp 
        195                 200                 205             


Thr Ser Phe Lys Val Glu Leu Lys Ser Tyr Leu Thr Thr Glu Ala Glu 
    210                 215                 220                 


Pro Leu Ile Lys Ile Glu Thr Pro Gly Lys Asn Lys Lys Thr Tyr Ser 
225                 230                 235                 240 


Phe Asp Leu Tyr Glu Gln Val Glu Pro Ile Gln Tyr Asn Glu Arg Thr 
                245                 250                 255     


Arg Thr Thr Gly Leu Asp Gly Glu Ile Phe Tyr Asn Leu Asp Arg Thr 
            260                 265                 270         


Leu Thr Gly Asn Gln Thr Leu Glu Leu Leu Thr Thr Glu Thr Pro Gly 
        275                 280                 285             


Ala Val Phe Gly Lys Gln Asp Asn Leu Glu Pro Gln Val Phe Ser Tyr 
    290                 295                 300                 


Asp Val Asp Ile Asn Gly Gln Ile Leu Pro Glu Thr Gln Thr Leu Leu 
305                 310                 315                 320 


Thr Pro Gly Lys Asp Tyr Thr Leu Ser Asp Asn Ser Leu Gly Arg Ile 
                325                 330                 335     


Ala Val Thr Val Pro Asn Met Asn Gln Gln Lys Ala Tyr Ser Leu Ser 
            340                 345                 350         


Ile Asn Arg Thr Ile Tyr Leu Glu Ser Ala Ser Asp Tyr Asn Tyr Leu 
        355                 360                 365             


Tyr Ser Gln Gln Tyr Pro Thr Thr Lys Ile Gly Ser Ile Ser Leu Lys 
    370                 375                 380                 


Ser Thr Thr Gly Thr Lys Gln Thr Thr Asp Phe Thr Ala Lys Thr Ser 
385                 390                 395                 400 


Gln Thr Ser Lys Val Ile Ala Asp Arg Glu Met Arg Ser Met Ser Tyr 
                405                 410                 415     


Ile Ser Phe Gln Ser Lys Gly Lys Tyr Tyr Val Thr Ile Tyr Gly Thr 
            420                 425                 430         


Leu Thr Glu Thr Lys Val Gly Gln Gln Ile Val Leu Glu Ser Thr Asn 
        435                 440                 445             


Gly Gln Glu Ile Lys Asn Pro Lys Phe Thr Ala Tyr Gly Pro Leu Tyr 
    450                 455                 460                 


Glu Asn Val Lys Leu Glu Asp Tyr Phe Asp Ile Lys Thr Glu Gly Gly 
465                 470                 475                 480 


Lys Leu Thr Leu Thr Ala Thr Lys Asp Ser Tyr Leu Arg Ile Asn Ile 
                485                 490                 495     


Ser Asp Leu Thr Met Asp Phe Asp Lys Lys Asp Ile Asn Leu Ser Leu 
            500                 505                 510         


Ser Thr Pro Val Ile Gly Pro Asn Lys Ala Ile Gln Leu Val Ser Asp 
        515                 520                 525             


Gln Tyr Ile Glu Pro Ile Ser Val Val Asn Pro Leu Asn Ala Glu Thr 
    530                 535                 540                 


Ala Trp Gly Asn Tyr Asp Gln Asn Gly Ala Tyr Ser Ser Arg Thr Thr 
545                 550                 555                 560 


Val Ser Val Met Gly Ser Lys Glu Lys Pro Ile Gln Asn Leu Glu Ile 
                565                 570                 575     


Lys Val Lys His Pro Asn Tyr Leu Ser Leu Arg Ala Thr Lys Glu Ile 
            580                 585                 590         


Tyr Phe Tyr Tyr Lys Leu Gly Thr Asp Tyr Thr Val Thr Pro Thr Ser 
        595                 600                 605             


Asp Gly Ser Val Ile Lys Phe Thr Thr Pro Ile Thr Asn Glu Ile Gln 
    610                 615                 620                 


Ile Pro Ile Gly Phe Asn Tyr Val Pro Asp Ser Leu Pro Lys Asp Lys 
625                 630                 635                 640 


Ser Ile Pro Val Asp Thr Ile Pro Ile Thr Met Ser Ala Glu Gly Leu 
                645                 650                 655     


Thr Pro Val Asp Thr Thr Val Thr Thr Asn Ser Lys Arg Gly Ser Glu 
            660                 665                 670         


Arg Thr Leu Gln Ser Ser Lys Asn Gln Phe Leu Val Asn Ala Arg Asn 
        675                 680                 685             


Asp Ser Phe Asp Ser Leu Ser Val Arg Thr Lys Ile Pro Ala Gly Ala 
    690                 695                 700                 


Asp Val Leu Phe Asp Ile Tyr Asp Val Ser Asn Asp Gln Val Asp Ser 
705                 710                 715                 720 


Ile Tyr Pro Gln Tyr Trp Asp Arg Gly Gln Tyr Phe Asp Lys Pro Met 
                725                 730                 735     


Thr Pro Asn Ser Pro Gly Tyr Pro Thr Ile Thr Phe Asp Glu Asn Thr 
            740                 745                 750         


Asn Ser Tyr Thr Phe Asp Phe Gly Lys Thr Asn Lys Arg Tyr Ile Ile 
        755                 760                 765             


Glu Tyr Lys Asn Ala Asn Gly Trp Ile Asp Val Pro Thr Leu Tyr Ile 
    770                 775                 780                 


Thr Gly Thr Ala Lys Glu Pro Gln Ser Asn Asn Asn Glu Gly Ser Ala 
785                 790                 795                 800 


Ser Val Ser Val Gln Asn Glu Ala Leu Asp Ile Leu Ser Ala Thr Gln 
                805                 810                 815     


Ala Ala Asn Pro Thr Leu Lys Asn Val Thr Lys Thr Thr Val Thr Thr 
            820                 825                 830         


Lys Asn Ile Asp Asn Lys Thr His Arg Val Lys Asn Pro Thr Ile Glu 
        835                 840                 845             


Leu Thr Pro Lys Gly Thr Thr Asn Ala Gln Ile Asp Leu Asn Ser Ile 
    850                 855                 860                 


Thr Val Lys Gly Val Pro Glu Asp Ala Tyr Ser Leu Glu Lys Thr Thr 
865                 870                 875                 880 


Asn Gly Ala Lys Val Ile Phe Lys Asp Tyr Thr Leu Thr Glu Asn Ile 
                885                 890                 895     


Thr Ile Glu Tyr Asn Thr Val Ser Ala Asn Ala Gly Gln Ile Tyr Thr 
            900                 905                 910         


Glu Thr Thr Ile Asp Ser Glu Thr Leu Asn Gln Met Ser Ala Ser Lys 
        915                 920                 925             


Lys Lys Val Thr Thr Ala Pro Ile Thr Leu Lys Phe Ser Glu Gly Asp 
    930                 935                 940                 


Ala Glu Gly Ile Val Tyr Leu Ala Thr Ala Thr Phe Tyr Thr His Asn 
945                 950                 955                 960 


Val Glu Asp Glu Asn Gln Ala Ile Ala Lys Val Ser Phe Glu Leu Ile 
                965                 970                 975     


Asp Asn Val Thr His Thr Ala Thr Glu Phe Thr Thr Asp Glu Lys Gly 
            980                 985                 990         


Gln Tyr Ser Phe Asp Ala Ile Met  Thr Gly Asp Tyr Thr  Leu Arg Val 
        995                 1000                 1005             


Thr Asn  Val Pro Gln Glu Tyr  Ser Val Asp Glu Glu  Tyr Leu Thr 
    1010                 1015                 1020             


Gly Lys  Ala Ile Lys Leu Val  Lys Gly Asp Asn Gln  Leu Lys Ile 
    1025                 1030                 1035             


Pro Leu  Thr Lys Thr Ile Asp  His Ser Arg Leu Gln  Val Lys Asp 
    1040                 1045                 1050             


Ser Thr  Ile Tyr Val Gly Asp  Ser Trp Lys Pro Glu  Glu Asn Phe 
    1055                 1060                 1065             


Val Ser  Ala Thr Asp Lys Thr  Gly Gln Asp Val Pro  Phe Glu Lys 
    1070                 1075                 1080             


Ile Thr  Val Ser Gly Gln Val  Asp Asn Thr Lys Ala  Gly Val Tyr 
    1085                 1090                 1095             


Pro Ile  Ile Tyr Ser Asp Glu  Gly Lys Glu Glu Thr  Ala Tyr Val 
    1100                 1105                 1110             


Thr Val  Lys Pro Asp Gln Ser  Lys Leu Glu Val Lys  Asp Thr Thr 
    1115                 1120                 1125             


Ile Tyr  Val Gly Asp Ser Trp  Lys Pro Glu Asp Asn  Phe Val Ser 
    1130                 1135                 1140             


Ala Thr  Asp Lys Thr Gly Gln  Asp Val Pro Phe Glu  Lys Ile Asp 
    1145                 1150                 1155             


Val Gln  Gly Thr Val Asn Val  Asp Lys Ile Gly Asp  Tyr Glu Ile 
    1160                 1165                 1170             


Val Tyr  Lys Asn Gly Lys Lys  Glu Ala Lys Ala Ile  Val His Val 
    1175                 1180                 1185             


Arg Asp  Asp Ser Gln Leu Glu  Val Lys Asp Thr Thr  Ile Tyr Val 
    1190                 1195                 1200             


Gly Asp  Ser Trp Lys Pro Glu  Asp Asn Phe Val Ser  Ala Thr Asp 
    1205                 1210                 1215             


Lys Thr  Gly Gln Asp Val Pro  Phe Glu Lys Ile Thr  Val Ser Gly 
    1220                 1225                 1230             


Gln Val  Asp Thr Ser Lys Ala  Gly Val Tyr Pro Ile  Val Tyr Ser 
    1235                 1240                 1245             


Tyr Glu  Gly Lys Glu Glu Thr  Ala Asn Val Thr Val  Lys Pro Asp 
    1250                 1255                 1260             


Gln Ser  Lys Leu Glu Val Lys  Asp Thr Thr Ile Tyr  Val Gly Asp 
    1265                 1270                 1275             


Lys Trp  Glu Pro Glu Asp Asn  Phe Val Ser Ala Thr  Asp Lys Thr 
    1280                 1285                 1290             


Gly Gln  Asp Val Pro Phe Glu  Lys Ile Asp Val Gln  Gly Thr Val 
    1295                 1300                 1305             


Asn Val  Asp Lys Ile Gly Asp  Tyr Glu Ile Val Tyr  Lys Asn Gly 
    1310                 1315                 1320             


Thr Lys  Glu Ala Lys Ala Ile  Val His Val Arg Asp  Asp Ser Gln 
    1325                 1330                 1335             


Leu Glu  Val Lys Asp Thr Thr  Ile Tyr Val Gly Asp  Lys Trp Glu 
    1340                 1345                 1350             


Ala Glu  Asp Asn Phe Val Ser  Ala Thr Asp Lys Thr  Gly Gln Asp 
    1355                 1360                 1365             


Val Pro  Phe Glu Lys Ile Asp  Val Gln Gly Thr Val  Asn Val Asp 
    1370                 1375                 1380             


Lys Ile  Gly Asp Tyr Glu Ile  Val Tyr Lys Asn Gly  Thr Lys Glu 
    1385                 1390                 1395             


Ala Lys  Ala Ile Val His Val  Arg Asp Asp Ser Arg  Leu Gln Val 
    1400                 1405                 1410             


Lys Asp  Thr Thr Ile Tyr Val  Gly Asp Ser Trp Lys  Pro Glu Glu 
    1415                 1420                 1425             


Asn Phe  Val Ser Ala Thr Asp  Lys Thr Gly Gln Asp  Val Pro Phe 
    1430                 1435                 1440             


Glu Lys  Ile Thr Val Ser Gly  Gln Val Asp Thr Ser  Lys Ala Gly 
    1445                 1450                 1455             


Val Tyr  Pro Ile Ile Tyr Ser  Tyr Glu Gly Lys Glu  Glu Thr Ala 
    1460                 1465                 1470             


His Val  Ala Val Lys Pro Asp  Gln Ser Lys Leu Glu  Val Lys Asp 
    1475                 1480                 1485             


Thr Thr  Ile Tyr Val Gly Asp  Ser Trp Lys Pro Glu  Asp Asn Phe 
    1490                 1495                 1500             


Val Ser  Ala Thr Asp Arg Asp  Gly His Ala Ile Ser  Phe Asp Lys 
    1505                 1510                 1515             


Val Gln  Val Lys Gly Glu Val  Asp Thr Lys Lys Thr  Gly Glu Tyr 
    1520                 1525                 1530             


Gln Ile  Ser Tyr Thr Thr Glu  Pro Val Asn Glu Thr  Lys Pro Ala 
    1535                 1540                 1545             


Val Gln  Ser Arg Leu Phe Ser  Met Phe Ser Asn Glu  Thr Pro Arg 
    1550                 1555                 1560             


Gln Leu  Thr Thr Val Ala Thr  Val His Val Ile Asp  Arg Asn Pro 
    1565                 1570                 1575             


Thr Pro  Leu Pro Asp Lys Asn  Glu Asn Asn Gln Thr  Ser Ser Ser 
    1580                 1585                 1590             


Thr Asn  Gln Thr Thr Ile Lys  Ser Ser Gln Tyr Val  Thr His Ile 
    1595                 1600                 1605             


Val Lys  Pro Asp Lys Gln Gly  Arg Tyr Pro Lys Thr  Gly Glu Gln 
    1610                 1615                 1620             


Thr Asn  Gly Leu Tyr Arg Val  Leu Gly Leu Val Val  Leu Leu Ile 
    1625                 1630                 1635             


Val Ile  Ile Ser Gly Ile Val  Ile Lys Lys Lys Arg  Lys 
    1640                 1645                 1650     


<210>  2
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  2

Gln Arg Leu Ser Thr Gly Ser Arg Ile Asn Ser Ala Lys Asp Asp Ala 
1               5                   10                  15      


Ala Gly Leu Gln Ile Ala 
            20          


<210>  3
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  n is a, c, g, or t

<400>  3
tcgnntcgnn tcg                                                          13


