                                SEQUENCE LISTING

<110> Ho, Mitchell
      Pastan, Ira
      The Government of the United States of America
         as represented by The Secretary of the
         Department of Health and Human Services

<120> Anti-Mesothelin Antibodies
  

<130> 015280-565100PC

<140> WO PCT/US10/Not yet assigned        
<141> Not yet assigned  

<150> US 61/162,778       
<151> 2009-03-24  

<160> 61

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH)

<400> 1
caggtccagc tggtgcagtc tggggctgag gtgaagaggc ctggggcctc agtgcaggta 60
tcctgcagag catctggcta tagtatcaat acttactata tgcagtgggt gcggcaggcc 120
cctggagcag gccttgagtg gatgggcgtt atcaacccca gtggtgtcac aagttacgca 180
cagaagttcc agggcagagt cactttgacc aacgacacgt ccacaaacac agtctacatg 240
cagttgaaca gtctgacatc tgccgacacg gccgtctact actgtgcgag atgggcctta 300
tggggggact tcggtatgga cgtctggggc aagggaaccc tggtcaccgt ctcgagt    357

<210> 2
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH)

<400> 2
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr Tyr
            20                  25                  30          
Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln
    50                  55                  60                  
Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr Met
65                  70                  75                  80  
Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 3
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region kappa light chain (VL)

<400> 3
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctattggaga cagagtcacc 60
atcacctgcc gggccagtga gggtatttat cactggttgg cctggtatca gcagaagcca 120
gggaaagccc ctaaactcct gatctataag gcctctagtt tagccagtgg ggctccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gatgattttg caacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga 300
gggaccaagc tggagatcaa a                                           321

<210> 4
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region kappa light chain (VL)

<400> 4
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 5
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region heavy chain (VH)

<400> 5
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagaccc 60
tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacacactac 180
gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgt gagaggaggg 300
gctttgggct ttgacaactg gggccgaggg acaatggtca ccgtctcgag t          351

<210> 6
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region heavy chain (VH)

<400> 6
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Pro Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr His Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Val Arg Gly Gly Ala Leu Gly Phe Asp Asn Trp Gly Arg Gly Thr Met
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 7
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region lambda light chain (VL)

<400> 7
gtgctgactc agccaccctc ggtgtctgaa gcccccaggc agagggtcac catttcctgt 60
tctggaagca cctccaacat cggaagtaat gttgttaact ggtaccagca gttcccagga 120
aagcctccca aagtcgtcat ctattatgat gatctggtgg cctcaggggt ctctgaccga 180
ttttccggct ccaggtctgg cacttcagcc tccctggcca tcagtgggct ccagtctgaa 240
gatgaagctg attattattg ttcagcatgg gatgacagcc tgaatgcctg ggtgttcggt 300
ggagggacca aggtcaccgt c                                           321

<210> 8
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region lambda light chain (VL)

<400> 8
Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg Val
 1               5                  10                  15      
Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn Val Val
            20                  25                  30          
Asn Trp Tyr Gln Gln Phe Pro Gly Lys Pro Pro Lys Val Val Ile Tyr
        35                  40                  45              
Tyr Asp Asp Leu Val Ala Ser Gly Val Ser Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu Asn Ala
                85                  90                  95      
Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val
            100                 105         


<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH) complementarity
      determining region 1 (CDR1) defined according to
      ImMunoGeneTics database (IMGT)

<400> 9
Gly Tyr Ser Ile Asn Thr Tyr Tyr
 1               5              


<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH) complementarity
      determining region 2 (CDR2) defined according to
      ImMunoGeneTics database (IMGT)

<400> 10
Ile Asn Pro Ser Gly Val Thr
 1               5          


<210> 11
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH) complementarity
      determining region 3 (CDR3) defined according to
      ImMunoGeneTics database (IMGT)

<400> 11
Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val
 1               5                  10              


<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region kappa light chain (VL)
      complementarity determining region 1 (CDR1)
      defined according to ImMunoGeneTics database (IMGT)

<400> 12
Glu Gly Ile Tyr His Trp
 1               5      


<210> 13
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region kappa light chain (VL)
      complementarity determining region 2 (CDR2)
      defined according to ImMunoGeneTics database (IMGT)

<400> 13
Lys Ala Ser
 1          


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region kappa light chain (VL)
      complementarity determining region 3 (CDR3)
      defined according to ImMunoGeneTics database (IMGT)

<400> 14
Gln Gln Tyr Ser Asn Tyr Pro Leu Thr
 1               5                  


<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region heavy chain (VH) complementarity
      determining region 1 (CDR1) defined according to
      ImMunoGeneTics database (IMGT)

<400> 15
Gly Phe Thr Phe Ser Ser Tyr Ala
 1               5              


<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region heavy chain (VH) complementarity
      determining region 2 (CDR2) defined according to
      ImMunoGeneTics database (IMGT)

<400> 16
Ile Ser Gly Ser Gly Gly Ser Thr
 1               5              


<210> 17
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region heavy chain (VH) complementarity
      determining region 3 (CDR3) defined according to
      ImMunoGeneTics database (IMGT)

<400> 17
Val Arg Gly Gly Ala Leu Gly Phe Asp Asn
 1               5                  10  


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region lambda light chain (VL)
      complementarity determining region 1 (CDR1)
      defined according to ImMunoGeneTics database (IMGT)

<400> 18
Thr Ser Asn Ile Gly Ser Asn Val Val
 1               5                  


<210> 19
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region lambda light chain (VL)
      complementarity determining region 2 (CDR2)
      defined according to ImMunoGeneTics database (IMGT)

<400> 19
Tyr Asp Asp
 1          


<210> 20
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region lambda light chain (VL)
      complementarity determining region 3 (CDR3)
      defined according to ImMunoGeneTics database (IMGT)

<400> 20
Ser Ala Trp Asp Asp Ser Leu Asn Ala Trp Val
 1               5                  10      


<210> 21
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH) homolog AAW67386

<400> 21
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Trp Phe Gly Asp Phe Gly Phe Asp Pro Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 22
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH) homolog BAC01455

<400> 22
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Arg Gly Tyr Gly Asp Tyr Ala Phe Asp Ile Trp Gly Gln
            100                 105                 110         
Gly Thr Met Val Thr Val Ser Ser
        115                 120 


<210> 23
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH) homolog ABM67163

<400> 23
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Lys Gly Tyr Gly Asp Tyr Ile Pro Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 24
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH) homolog AAY23310

<400> 24
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Ser Val Ala Gly Thr Tyr Leu Ile Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 25
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH) homolog AAK57785

<400> 25
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Gly Val Ser Thr Ser Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Arg Ile Ala Val Ala Gly Thr Asp Ala Phe Asp Ile Trp
            100                 105                 110         
Gly Gln Gly Thr Met Val Thr Val Cys Ser
        115                 120         


<210> 26
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region heavy chain (VH) homolog AAF75632

<400> 26
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Pro Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Ala Ser Ser Ser Gly Tyr Tyr Tyr Val His Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 27
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region heavy chain (VH) homolog BAC02290

<400> 27
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Pro Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Ser Asp Tyr Gly Asp Tyr Leu Tyr Tyr Trp Tyr Phe Asp
            100                 105                 110         
Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 28
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region heavy chain (VH) homolog BAA36318

<400> 28
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Gly Glu Leu Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 29
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region heavy chain (VH) homolog BAG62929

<400> 29
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Leu Asp Gly Gly Asn Glu Cys Leu Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 30
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region heavy chain (VH) homolog AAA52996

<400> 30
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Asp Ala Gly Trp Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 31
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region lambda light chain (VL) homolog
      BAH04805

<400> 31
Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg Val
 1               5                  10                  15      
Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val
            20                  25                  30          
Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
        35                  40                  45              
Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Ala
                85                  90                  95      
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val
            100                 105         


<210> 32
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region lambda light chain (VL) homolog
      AAQ56716

<400> 32
Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg Val
 1               5                  10                  15      
Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val
            20                  25                  30          
Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
        35                  40                  45              
Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ala Ser
                85                  90                  95      
Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val
            100                 105         


<210> 33
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region lambda light chain (VL) homolog
      CAG27374

<400> 33
Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg Val
 1               5                  10                  15      
Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val
            20                  25                  30          
Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
        35                  40                  45              
Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly
                85                  90                  95      
Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val
            100                 105         


<210> 34
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region lambda light chain (VL) homolog
      AAZ13621

<400> 34
Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg Val
 1               5                  10                  15      
Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val
            20                  25                  30          
Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
        35                  40                  45              
Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly
                85                  90                  95      
Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val
            100                 105         


<210> 35
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN2
      variable region lambda light chain (VL) homolog
      CAD23536

<400> 35
Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg Val
 1               5                  10                  15      
Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val
            20                  25                  30          
Asn Trp Tyr Gln Gln Leu Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr
        35                  40                  45              
Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly
                85                  90                  95      
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val
            100                 105         


<210> 36
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide linker separating VH and VL
      regions

<400> 36
Gly Gly Gly Ser
 1              


<210> 37
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic Pseudomonas exotoxin additional carboxyl
      terminus

<400> 37
Lys Asp Glu Leu
 1              


<210> 38
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic Pseudomonas exotoxin additional carboxyl
      terminus

<400> 38
Arg Glu Asp Leu
 1              


<210> 39
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH) complementarity
      determining region 1 (CDR1) defined according to
      Kabat

<400> 39
Thr Tyr Tyr Met Gln
 1               5  


<210> 40
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH) complementarity
      determining region 2 (CDR2) defined according to
      Kabat

<400> 40
Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln Gly
 1               5                  10                  15      


<210> 41
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region heavy chain (VH) complementarity
      determining region 3 (CDR3) defined according to
      Kabat

<400> 41
Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val
 1               5                  10      


<210> 42
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region kappa light chain (VL)
      complementarity determining region 1 (CDR1)
      defined according to Kabat

<400> 42
Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
 1               5                  10      


<210> 43
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region kappa light chain (VL)
      complementarity determining region 2 (CDR2)
      defined according to Kabat

<400> 43
Lys Ala Ser Leu Ala Ser
 1               5      


<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      variable region kappa light chain (VL)
      complementarity determining region 3 (CDR3)
      defined according to Kabat

<400> 44
Gln Gln Tyr Ser Asn Tyr Pro Leu Thr
 1               5                  


<210> 45
<211> 732
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      single-chain Fv antibody (scFv)

<400> 45
atggcccagg tccagctggt gcagtctggg gctgaggtga agaggcctgg ggcctcagtg 60
caggtatcct gcagagcatc tggctatagt atcaatactt actatatgca gtgggtgcgg 120
caggcccctg gagcaggcct tgagtggatg ggcgttatca accccagtgg tgtcacaagt 180
tacgcacaga agttccaggg cagagtcact ttgaccaacg acacgtccac aaacacagtc 240
tacatgcagt tgaacagtct gacatctgcc gacacggccg tctactactg tgcgagatgg 300
gccttatggg gggacttcgg tatggacgtc tggggcaagg gaaccctggt caccgtctcg 360
agtggtggag gcggttcagg cggaggtggc agcggcggtg gcggatcgga catccagatg 420
acccagtctc cttccaccct gtctgcatct attggagaca gagtcaccat cacctgccgg 480
gccagtgagg gtatttatca ctggttggcc tggtatcagc agaagccagg gaaagcccct 540
aaactcctga tctataaggc ctctagttta gccagtgggg ccccatcaag gttcagcggc 600
agtggatctg ggacagattt cactctcacc atcagcagcc tgcagcctga tgattttgca 660
acttattact gccaacaata tagtaattat ccgctcactt tcggcggagg gaccaagctg 720
gagatcaaac gt                                                     732

<210> 46
<211> 244
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      single-chain Fv antibody (scFv)

<400> 46
Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro
 1               5                  10                  15      
Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn
            20                  25                  30          
Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu
        35                  40                  45              
Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys
    50                  55                  60                  
Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val
65                  70                  75                  80  
Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly
            100                 105                 110         
Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro
    130                 135                 140                 
Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg
145                 150                 155                 160 
Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro
                165                 170                 175     
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser
            180                 185                 190         
Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
        195                 200                 205             
Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys
    210                 215                 220                 
Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu
225                 230                 235                 240 
Glu Ile Lys Arg
                


<210> 47
<211> 993
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic heavy chain IgG1 constant region

<400> 47
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc 300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 720
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 780
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 840
ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 900
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 960
cagaagagcc tctccctgtc tccgggtaaa tga                              993

<210> 48
<211> 329
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic heavy chain IgG1 constant region

<400> 48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly
                325                 


<210> 49
<211> 1515
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      including IgG1 heavy chain constant region

<400> 49
atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctgggta cgtgaaccgt 60
cagatcgcct ggagacgcca tcgaattctg agcacacagg acctcaccat ggactggacc 120
tggaggatcc tcttcttggt ggcagcagcc acaggagctc actcccaggt ccagctggtg 180
cagtctgggg ctgaggtgaa gaggcctggg gcctcagtgc aggtatcctg cagagcatct 240
ggctatagta tcaatactta ctatatgcag tgggtgcggc aggcccctgg agcaggcctt 300
gagtggatgg gcgttatcaa ccccagtggt gtcacaagtt acgcacagaa gttccagggc 360
agagtcactt tgaccaacga cacgtccaca aacacagtct acatgcagtt gaacagtctg 420
acatctgccg acacggccgt ctactactgt gcgagatggg ccttatgggg ggacttcggt 480
atggacgtct ggggcaaggg aaccctggtc accgtctcga gtgcctccac caagggccca 540
tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc 600
tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg 660
accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc 720
agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat 780
cacaagccca gcaacaccaa ggtggacaag aaagttgagc ccaaatcttg tgacaaaact 840
cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc 900
cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 960
gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1020
gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1080
agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc 1140
tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1200
cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc 1260
agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 1320
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1380
ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 1440
tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 1500
tctccgggta aatga                                                  1515

<210> 50
<211> 504
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      including IgG1 heavy chain constant region

<400> 50
Met Gly Gly Arg Arg Val Arg Trp Glu Val Tyr Ile Ser Arg Ala Gly
 1               5                  10                  15      
Tyr Val Asn Arg Gln Ile Ala Trp Arg Arg His Arg Ile Leu Ser Thr
            20                  25                  30          
Gln Asp Leu Thr Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala
        35                  40                  45              
Ala Ala Thr Gly Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala
    50                  55                  60                  
Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser
65                  70                  75                  80  
Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro
                85                  90                  95      
Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr
            100                 105                 110         
Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr
        115                 120                 125             
Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp
    130                 135                 140                 
Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly
145                 150                 155                 160 
Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser
                165                 170                 175     
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
            180                 185                 190         
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro
        195                 200                 205             
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
    210                 215                 220                 
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
225                 230                 235                 240 
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
                245                 250                 255     
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
            260                 265                 270         
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
        275                 280                 285             
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
    290                 295                 300                 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
305                 310                 315                 320 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
                325                 330                 335     
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
            340                 345                 350         
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
        355                 360                 365             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
    370                 375                 380                 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
385                 390                 395                 400 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
                405                 410                 415     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
            420                 425                 430         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
        435                 440                 445             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
    450                 455                 460                 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
465                 470                 475                 480 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                485                 490                 495     
Ser Leu Ser Leu Ser Pro Gly Lys
            500                 


<210> 51
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic kappa light chain

<400> 51
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 60
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 120
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 180
aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 240
cacaaagtct acgcctgcga agtcacccat cagggcctga gttcgcccgt cacaaagagc 300
ttcaacaggg gagagtgtta a                                           321

<210> 52
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic kappa light chain

<400> 52
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105     


<210> 53
<211> 813
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      light chain including kappa chain

<400> 53
atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctgggta cgtgaaccgt 60
cagatcgcct ggagacgcca tcgaattctg agcacacagg acctcaccat ggtgttgcag 120
acccaggtct tcataagctt gttgctctgg atctctggtg cctacgggga catccagatg 180
acccagtctc cttccaccct gtctgcatct attggagaca gagtcaccat cacctgccgg 240
gccagtgagg gtatttatca ctggttggcc tggtatcagc agaagccagg gaaagcccct 300
aaactcctga tctataaggc ctctagttta gccagtgggg ctccatcaag gttcagcggc 360
agtggatctg ggacagattt cactctcacc atcagcagcc tgcagcctga tgattttgca 420
acttattact gccaacaata tagtaattat ccgctcactt tcggcggagg gaccaagctg 480
gagatcaaac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 540
ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc 600
aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca 660
gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca 720
gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagttcgccc 780
gtcacaaaga gcttcaacag gggagagtgt taa                              813

<210> 54
<211> 270
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      light chain including kappa chain

<400> 54
Met Gly Gly Arg Arg Val Arg Trp Glu Val Tyr Ile Ser Arg Ala Gly
 1               5                  10                  15      
Tyr Val Asn Arg Gln Ile Ala Trp Arg Arg His Arg Ile Leu Ser Thr
            20                  25                  30          
Gln Asp Leu Thr Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu
        35                  40                  45              
Leu Trp Ile Ser Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro
    50                  55                  60                  
Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg
65                  70                  75                  80  
Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro
                85                  90                  95      
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser
            100                 105                 110         
Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
        115                 120                 125             
Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys
    130                 135                 140                 
Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu
145                 150                 155                 160 
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                165                 170                 175     
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
            180                 185                 190         
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
        195                 200                 205             
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
    210                 215                 220                 
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
225                 230                 235                 240 
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
                245                 250                 255     
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            260                 265                 270 


<210> 55
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic Pseudomonas exotoxin native C-terminal
      end, residues 609-613

<400> 55
Arg Glu Asp Leu Lys
 1               5  


<210> 56
<211> 98
<212> PRT
<213> Homo sapiens

<220> 
<223> variable heavy chain region IGHV1-46 germline
      sequence

<400> 56
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Ser Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg
        

<210> 57
<211> 95
<212> PRT
<213> Homo sapiens

<220> 
<223> variable light chain region IGKV1-5*03 germline
      sequence

<400> 57
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro
                85                  90                  95  


<210> 58
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      scFv VH region PCR amplification forward primer
      VH-HN1-F

<400> 58
gaggaggaag agctcactcc caggtccagc tggtgcagtc tgg                   43

<210> 59
<211> 49
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      scFv VH region PCR amplification reverse primer
      VH-HN1-R

<400> 59
gaggaggaag ggcccttggt ggaggcactc gagacggtga ccagggttc             49

<210> 60
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      scFv VL region PCR amplification forward primer
      VL-HN1-F

<400> 60
gaggaggaaa agcttgttgc tctggatctc tggtgcctac ggggacatcc agatgaccca 60
gtctcc                                                            66

<210> 61
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-mesothelin monoclonal antibody HN1
      scFv VL region PCR amplification reverse primer
      VL-HN1-R

<400> 61
gaggaggagc gtacgtttga tctccagctt ggtcc                            35


