                         SEQUENCE LISTING

<110>  Quark Pharmaceuticals, Inc.
 
<120>  Compounds, Compositions and Methods of Treating Cancer and 
       Fibrotic Diseases

<130>  202/PCT1

<150>  US 61/162,348
<151>  2009-04-23

<160>  9     

<170>  PatentIn version 3.3

<210>  1
<211>  5641
<212>  RNA
<213>  Homo sapiens

<400>  1
cggaggagga cgcgagcccc uugcgggcgg ucaucacagc ccagccucgg ggcugccaca     60

gcgcguugcg ccugugcgcc cucggucccc gcguccacug agcgccgcgc ucggggaugg    120

ggcccggccg gccggccccc gcgcccuggc cucgucaccu gcugcgcugc guccugcucc    180

ucgggugccu gcaccucggc cgucccggcg ccccugggga cgccgcccuc ccggaaccca    240

acgucuuccu caucuucagc cauggacugc agggcugccu ggaggcccag ggcgggcagg    300

ucagagucac cccggcuugc aauaccagcc ucccugccca gcgcuggaag ugggucuccc    360

gaaaccggcu auucaaccug gguaccaugc agugccuggg cacaggcugg ccaggcacca    420

acaccacggc cucccugggc auguaugagu gugaccggga agcacugaau cuucgcuggc    480

auugucguac acugggugac cagcuguccu ugcuccuggg ggcccgcacc agcaacauau    540

ccaagccugg cacccuugag cguggugacc agacccgcag uggccagugg cgcaucuacg    600

gcagcgagga ggaccuaugu gcucugcccu accacgaggu cuacaccauc cagggaaacu    660

cccacggaaa gccgugcacc auccccuuca aauaugacaa ccagugguuc cacggcugca    720

ccagcacggg ccgcgaggau ggucaccugu ggugugccac cacccaggac uacggcaaag    780

acgagcgcug gggcuucugc cccaucaaga guaacgacug cgagaccuuc ugggacaagg    840

accagcugac ugacagcugc uaccaguuua acuuccaguc cacgcugucg uggagggagg    900

ccugggccag cugcgagcag cagggugcgg aucugcugag caucacggag auccacgagc    960

agaccuacau caacggccuc cucacugggu acagcuccac ccuguggauc ggcuugaaug   1020

acuuggacac gagcggaggc uggcaguggu cggacaacuc gccccucaag uaccucaacu   1080

gggagaguga ccagccggac aaccccagug aggagaacug uggagugauc cgcacugagu   1140

ccucgggcgg cuggcagaac cgugacugca gcaucgcgcu gcccuaugug ugcaagaaga   1200

agcccaacgc cacggccgag cccaccccuc cagacaggug ggccaaugug aagguggagu   1260

gcgagccgag cuggcagccc uuccagggcc acugcuaccg ccugcaggcc gagaagcgca   1320

gcuggcagga guccaagaag gcaugucuac ggggcggugg cgaccugguc agcauccaca   1380

gcauggcgga gcuggaauuc aucaccaagc agaucaagca agagguggag gagcugugga   1440

ucggccucaa cgauuugaaa cugcagauga auuuugagug gucugacggg agccuuguga   1500

gcuucaccca cuggcacccc uuugagccca acaacuuccg ggacagucug gaggacugug   1560

ucaccaucug gggcccggaa ggccgcugga acgacagucc cuguaaccag uccuugccau   1620

ccaucugcaa gaaggcaggc cagcugagcc agggggccgc cgaggaggac cauggcugcc   1680

ggaaggguug gacguggcac agcccauccu gcuacuggcu gggagaagac caagugaccu   1740

acagugaggc ccggcgccug ugcacugacc auggcucuca gcuggucacc aucaccaaca   1800

gguucgagca ggccuucguc agcagccuca ucuacaacug ggagggcgag uacuucugga   1860

cggcccugca ggaccucaac agcaccggcu ccuucuucug gcucaguggg gaugaaguca   1920

uguacaccca cuggaaccgg gaccagcccg gguacagccg ugggggcugc guggcgcugg   1980

ccacuggcag cgccaugggg cugugggagg ugaagaacug uaccucguuc cgggcccgcu   2040

acaucugccg gcagagccug ggcacuccag ugacgccgga gcugccgggg ccagauccca   2100

cgcccagccu cacuggcucc uguccccagg gcugggccuc ggacaccaaa cuccgguauu   2160

gcuauaaggu guucagcuca gagcggcugc aggacaagaa gagcuggguc caggcccagg   2220

gggccugcca ggagcugggg gcccagcugc ugagccuggc cagcuacgag gaggagcacu   2280

uuguggccaa caugcucaac aagaucuucg gugaaucaga acccgagauc cacgagcagc   2340

acugguucug gaucggccug aaccgucggg aucccagagg gggucagagu uggcgcugga   2400

gcgacggcgu aggguucucu uaccacaauu ucgaccggag ccggcacgac gacgacgaca   2460

uccgaggcug ugcggugcug gaccuggccu cccugcagug gguggccaug cagugcgaca   2520

cacagcugga cuggaucugc aagaucccca gagguacgga cgugcgggag cccgacgaca   2580

gcccucaagg ccgacgggaa uggcugcgcu uccaggaggc cgaguacaag uucuuugagc   2640

accacuccac gugggcgcag gcgcagcgca ucugcacgug guuccaggcc gagcugaccu   2700

ccgugcacag ccaggcagag cuagacuucc ugagccacaa cuugcagaag uucucccggg   2760

cccaggagca gcacuggugg aucggccugc acaccucuga gagcgauggg cgcuucagau   2820

ggacagaugg uuccauuaua aacuucaucu ccugggcacc aggcaaaccu cggccugucg   2880

gcaaggacaa gaagugcgug uacaugacag ccagccgaga ggacuggggg gaccagaggu   2940

gccugacagc cuugcccuac aucugcaagc gcagcaacgu caccaaagaa acgcagcccc   3000

cagaccugcc aacuacagcc cuggggggcu gccccucuga cuggauccag uuccucaaca   3060

aguguuuuca gguccagggc caggaacccc agagccgggu gaagugguca gaggcacagu   3120

ucuccuguga acagcaagag gcccagcugg ucaccaucac aaaccccuua gagcaagcau   3180

ucaucacagc cagccugccc aaugugaccu uugaccuuug gauuggccuc caugccucgc   3240

agagggacuu ccagugggug gagcaggagc cuuugaugua ugccaacugg gcaccugggg   3300

agcccucugg cccuagcccu gcucccagug gcaacaaacc gaccagcugu gcgguggucc   3360

ugcacagccc cucagcccac uucacuggcc gcugggacga ucggagcugc acggaggaga   3420

cccauggcuu caucugccag aagggcacgg accccucccu gagcccgucc ccagcagcgc   3480

ugccccccgc cccgggcacu gagcucuccu accucaacgg caccuuccgg cugcuucaga   3540

agccgcugcg cuggcacgau gcccuccugc ugugugagag ccacaaugcc agccuggccu   3600

acgugcccga ccccuacacc caggccuucc ucacgcaggc ugcccgaggg cugcgcacgc   3660

cgcucuggau ugggcuggcu ggcgaggagg gcucucggcg guacuccugg gucucagagg   3720

agccgcugaa cuacgugggc uggcaggacg gggagccgca gcagccgggg ggcuguaccu   3780

acguagaugu ggacggggcc uggcgcacca ccagcuguga caccaagcug cagggggcug   3840

uguguggggu uagcaguggg cccccuccuc cccgaagaau aagcuaccau ggcagcuguc   3900

cccagggacu ggcagacucc gcguggauuc ccuuccggga gcacugcuau ucuuuccaca   3960

uggagcugcu gcugggccac aaggaggcgc gacagcgcug ccagagagcg gguggggccg   4020

uccugucuau ccuggaugag auggagaaug uguuugucug ggagcaccug cagagcuaug   4080

agggccagag ucggggcgcc uggcugggca ugaacuucaa ccccaaagga ggcacucugg   4140

ucuggcagga caacacagcu gugaacuacu ccaacugggg gcccccgggc uugggcccca   4200

gcaugcugag ccacaacagc ugcuacugga uucagagcaa cagcgggcua uggcgccccg   4260

gcgcuugcac caacaucacc augggugucg ucugcaagcu uccucgugcu gagcagagca   4320

gcuucucccc aucagcgcuu ccagagaacc cagcggcccu ggugguggug cugauggcgg   4380

ugcugcugcu ccuggccuug cugaccgcag cccucauccu uuaccggagg cgccagagca   4440

ucgagcgcgg ggccuuugag ggugcccgcu acagccgcag cagcuccagc cccaccgagg   4500

ccacugagaa gaacauccug gugucagaca uggaaaugaa ugagcaacaa gaauagagcc   4560

aggcgcgugg gcagggccag ggcgggagga gcuggggagc uggggcccug ggucagucug   4620

gccccccacc agcugccugu ccaguuggcc uauggaaggg ugcccuuggg agucgcuguu   4680

gggagccgga gcugggcaga gccugggcug guggggugcc acccucccac aagggcuggg   4740

cugagaccca gcugagugca gcguggcguu ucccuuucug ggggggccug aggucuuguc   4800

accugguccu gugcccccac aggaaccaga gguaggaugg gagggggaac gagagccucu   4860

uucuccccag agcccccggc ccaggccugu ugauccgcgc cccaggaccc ccuucuuugc   4920

agagcccgag gagccucccc uguccccucg ggcagaucug uugugucucu cuucccaccu   4980

ggcagccuca gcucugugcc ccucacccug cucccucucg ccccuucucu cccaccccuu   5040

ccuucugagc cgggcccugg ggauugggga gcccucuugu uccugaugag ggucagcuga   5100

gggggcugag cauccaucac uccugugccu gcuggggugg cuguggggcg uggcaggagg   5160

ggccuaggug gguugggccu gagaaccagg gcacgggugu ggugucugcu gggcuggaga   5220

uaagacuggg gagagacacc ccaaccuccc agggugggag cugggccggg cugggauguc   5280

aucuccugcc gggcggggga gggcucugcc ccuggaagag uccccugugg ggaccaaaau   5340

aaguucccua acaucuccag cuccuggcuc ugguuuggag caaggggaag gguugccaga   5400

guccuggggg ccccagagga gcaggagucu gggagggccc agaguucacc cucuagugga   5460

uccaggagga gcagcacccg agcccuggag uggcccagua cccuuccaag aggccacagu   5520

cccagccagg acaaaguaug cggcccaucc uggugcgaca gcgugggaca augugaacau   5580

ggacucgaag acauggcccu uucucuguag uugauuuuuu aaaugugcca uuauuguuuu   5640

u                                                                   5641


<210>  2
<211>  1479
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Pro Gly Arg Pro Ala Pro Ala Pro Trp Pro Arg His Leu Leu 
1               5                   10                  15      


Arg Cys Val Leu Leu Leu Gly Cys Leu His Leu Gly Arg Pro Gly Ala 
            20                  25                  30          


Pro Gly Asp Ala Ala Leu Pro Glu Pro Asn Val Phe Leu Ile Phe Ser 
        35                  40                  45              


His Gly Leu Gln Gly Cys Leu Glu Ala Gln Gly Gly Gln Val Arg Val 
    50                  55                  60                  


Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gln Arg Trp Lys Trp Val 
65                  70                  75                  80  


Ser Arg Asn Arg Leu Phe Asn Leu Gly Thr Met Gln Cys Leu Gly Thr 
                85                  90                  95      


Gly Trp Pro Gly Thr Asn Thr Thr Ala Ser Leu Gly Met Tyr Glu Cys 
            100                 105                 110         


Asp Arg Glu Ala Leu Asn Leu Arg Trp His Cys Arg Thr Leu Gly Asp 
        115                 120                 125             


Gln Leu Ser Leu Leu Leu Gly Ala Arg Thr Ser Asn Ile Ser Lys Pro 
    130                 135                 140                 


Gly Thr Leu Glu Arg Gly Asp Gln Thr Arg Ser Gly Gln Trp Arg Ile 
145                 150                 155                 160 


Tyr Gly Ser Glu Glu Asp Leu Cys Ala Leu Pro Tyr His Glu Val Tyr 
                165                 170                 175     


Thr Ile Gln Gly Asn Ser His Gly Lys Pro Cys Thr Ile Pro Phe Lys 
            180                 185                 190         


Tyr Asp Asn Gln Trp Phe His Gly Cys Thr Ser Thr Gly Arg Glu Asp 
        195                 200                 205             


Gly His Leu Trp Cys Ala Thr Thr Gln Asp Tyr Gly Lys Asp Glu Arg 
    210                 215                 220                 


Trp Gly Phe Cys Pro Ile Lys Ser Asn Asp Cys Glu Thr Phe Trp Asp 
225                 230                 235                 240 


Lys Asp Gln Leu Thr Asp Ser Cys Tyr Gln Phe Asn Phe Gln Ser Thr 
                245                 250                 255     


Leu Ser Trp Arg Glu Ala Trp Ala Ser Cys Glu Gln Gln Gly Ala Asp 
            260                 265                 270         


Leu Leu Ser Ile Thr Glu Ile His Glu Gln Thr Tyr Ile Asn Gly Leu 
        275                 280                 285             


Leu Thr Gly Tyr Ser Ser Thr Leu Trp Ile Gly Leu Asn Asp Leu Asp 
    290                 295                 300                 


Thr Ser Gly Gly Trp Gln Trp Ser Asp Asn Ser Pro Leu Lys Tyr Leu 
305                 310                 315                 320 


Asn Trp Glu Ser Asp Gln Pro Asp Asn Pro Ser Glu Glu Asn Cys Gly 
                325                 330                 335     


Val Ile Arg Thr Glu Ser Ser Gly Gly Trp Gln Asn Arg Asp Cys Ser 
            340                 345                 350         


Ile Ala Leu Pro Tyr Val Cys Lys Lys Lys Pro Asn Ala Thr Ala Glu 
        355                 360                 365             


Pro Thr Pro Pro Asp Arg Trp Ala Asn Val Lys Val Glu Cys Glu Pro 
    370                 375                 380                 


Ser Trp Gln Pro Phe Gln Gly His Cys Tyr Arg Leu Gln Ala Glu Lys 
385                 390                 395                 400 


Arg Ser Trp Gln Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly Gly Asp 
                405                 410                 415     


Leu Val Ser Ile His Ser Met Ala Glu Leu Glu Phe Ile Thr Lys Gln 
            420                 425                 430         


Ile Lys Gln Glu Val Glu Glu Leu Trp Ile Gly Leu Asn Asp Leu Lys 
        435                 440                 445             


Leu Gln Met Asn Phe Glu Trp Ser Asp Gly Ser Leu Val Ser Phe Thr 
    450                 455                 460                 


His Trp His Pro Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu Glu Asp 
465                 470                 475                 480 


Cys Val Thr Ile Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser Pro Cys 
                485                 490                 495     


Asn Gln Ser Leu Pro Ser Ile Cys Lys Lys Ala Gly Gln Leu Ser Gln 
            500                 505                 510         


Gly Ala Ala Glu Glu Asp His Gly Cys Arg Lys Gly Trp Thr Trp His 
        515                 520                 525             


Ser Pro Ser Cys Tyr Trp Leu Gly Glu Asp Gln Val Thr Tyr Ser Glu 
    530                 535                 540                 


Ala Arg Arg Leu Cys Thr Asp His Gly Ser Gln Leu Val Thr Ile Thr 
545                 550                 555                 560 


Asn Arg Phe Glu Gln Ala Phe Val Ser Ser Leu Ile Tyr Asn Trp Glu 
                565                 570                 575     


Gly Glu Tyr Phe Trp Thr Ala Leu Gln Asp Leu Asn Ser Thr Gly Ser 
            580                 585                 590         


Phe Phe Trp Leu Ser Gly Asp Glu Val Met Tyr Thr His Trp Asn Arg 
        595                 600                 605             


Asp Gln Pro Gly Tyr Ser Arg Gly Gly Cys Val Ala Leu Ala Thr Gly 
    610                 615                 620                 


Ser Ala Met Gly Leu Trp Glu Val Lys Asn Cys Thr Ser Phe Arg Ala 
625                 630                 635                 640 


Arg Tyr Ile Cys Arg Gln Ser Leu Gly Thr Pro Val Thr Pro Glu Leu 
                645                 650                 655     


Pro Gly Pro Asp Pro Thr Pro Ser Leu Thr Gly Ser Cys Pro Gln Gly 
            660                 665                 670         


Trp Ala Ser Asp Thr Lys Leu Arg Tyr Cys Tyr Lys Val Phe Ser Ser 
        675                 680                 685             


Glu Arg Leu Gln Asp Lys Lys Ser Trp Val Gln Ala Gln Gly Ala Cys 
    690                 695                 700                 


Gln Glu Leu Gly Ala Gln Leu Leu Ser Leu Ala Ser Tyr Glu Glu Glu 
705                 710                 715                 720 


His Phe Val Ala Asn Met Leu Asn Lys Ile Phe Gly Glu Ser Glu Pro 
                725                 730                 735     


Glu Ile His Glu Gln His Trp Phe Trp Ile Gly Leu Asn Arg Arg Asp 
            740                 745                 750         


Pro Arg Gly Gly Gln Ser Trp Arg Trp Ser Asp Gly Val Gly Phe Ser 
        755                 760                 765             


Tyr His Asn Phe Asp Arg Ser Arg His Asp Asp Asp Asp Ile Arg Gly 
    770                 775                 780                 


Cys Ala Val Leu Asp Leu Ala Ser Leu Gln Trp Val Ala Met Gln Cys 
785                 790                 795                 800 


Asp Thr Gln Leu Asp Trp Ile Cys Lys Ile Pro Arg Gly Thr Asp Val 
                805                 810                 815     


Arg Glu Pro Asp Asp Ser Pro Gln Gly Arg Arg Glu Trp Leu Arg Phe 
            820                 825                 830         


Gln Glu Ala Glu Tyr Lys Phe Phe Glu His His Ser Thr Trp Ala Gln 
        835                 840                 845             


Ala Gln Arg Ile Cys Thr Trp Phe Gln Ala Glu Leu Thr Ser Val His 
    850                 855                 860                 


Ser Gln Ala Glu Leu Asp Phe Leu Ser His Asn Leu Gln Lys Phe Ser 
865                 870                 875                 880 


Arg Ala Gln Glu Gln His Trp Trp Ile Gly Leu His Thr Ser Glu Ser 
                885                 890                 895     


Asp Gly Arg Phe Arg Trp Thr Asp Gly Ser Ile Ile Asn Phe Ile Ser 
            900                 905                 910         


Trp Ala Pro Gly Lys Pro Arg Pro Val Gly Lys Asp Lys Lys Cys Val 
        915                 920                 925             


Tyr Met Thr Ala Ser Arg Glu Asp Trp Gly Asp Gln Arg Cys Leu Thr 
    930                 935                 940                 


Ala Leu Pro Tyr Ile Cys Lys Arg Ser Asn Val Thr Lys Glu Thr Gln 
945                 950                 955                 960 


Pro Pro Asp Leu Pro Thr Thr Ala Leu Gly Gly Cys Pro Ser Asp Trp 
                965                 970                 975     


Ile Gln Phe Leu Asn Lys Cys Phe Gln Val Gln Gly Gln Glu Pro Gln 
            980                 985                 990         


Ser Arg Val Lys Trp Ser Glu Ala  Gln Phe Ser Cys Glu  Gln Gln Glu 
        995                 1000                 1005             


Ala Gln  Leu Val Thr Ile Thr  Asn Pro Leu Glu Gln  Ala Phe Ile 
    1010                 1015                 1020             


Thr Ala  Ser Leu Pro Asn Val  Thr Phe Asp Leu Trp  Ile Gly Leu 
    1025                 1030                 1035             


His Ala  Ser Gln Arg Asp Phe  Gln Trp Val Glu Gln  Glu Pro Leu 
    1040                 1045                 1050             


Met Tyr  Ala Asn Trp Ala Pro  Gly Glu Pro Ser Gly  Pro Ser Pro 
    1055                 1060                 1065             


Ala Pro  Ser Gly Asn Lys Pro  Thr Ser Cys Ala Val  Val Leu His 
    1070                 1075                 1080             


Ser Pro  Ser Ala His Phe Thr  Gly Arg Trp Asp Asp  Arg Ser Cys 
    1085                 1090                 1095             


Thr Glu  Glu Thr His Gly Phe  Ile Cys Gln Lys Gly  Thr Asp Pro 
    1100                 1105                 1110             


Ser Leu  Ser Pro Ser Pro Ala  Ala Leu Pro Pro Ala  Pro Gly Thr 
    1115                 1120                 1125             


Glu Leu  Ser Tyr Leu Asn Gly  Thr Phe Arg Leu Leu  Gln Lys Pro 
    1130                 1135                 1140             


Leu Arg  Trp His Asp Ala Leu  Leu Leu Cys Glu Ser  His Asn Ala 
    1145                 1150                 1155             


Ser Leu  Ala Tyr Val Pro Asp  Pro Tyr Thr Gln Ala  Phe Leu Thr 
    1160                 1165                 1170             


Gln Ala  Ala Arg Gly Leu Arg  Thr Pro Leu Trp Ile  Gly Leu Ala 
    1175                 1180                 1185             


Gly Glu  Glu Gly Ser Arg Arg  Tyr Ser Trp Val Ser  Glu Glu Pro 
    1190                 1195                 1200             


Leu Asn  Tyr Val Gly Trp Gln  Asp Gly Glu Pro Gln  Gln Pro Gly 
    1205                 1210                 1215             


Gly Cys  Thr Tyr Val Asp Val  Asp Gly Ala Trp Arg  Thr Thr Ser 
    1220                 1225                 1230             


Cys Asp  Thr Lys Leu Gln Gly  Ala Val Cys Gly Val  Ser Ser Gly 
    1235                 1240                 1245             


Pro Pro  Pro Pro Arg Arg Ile  Ser Tyr His Gly Ser  Cys Pro Gln 
    1250                 1255                 1260             


Gly Leu  Ala Asp Ser Ala Trp  Ile Pro Phe Arg Glu  His Cys Tyr 
    1265                 1270                 1275             


Ser Phe  His Met Glu Leu Leu  Leu Gly His Lys Glu  Ala Arg Gln 
    1280                 1285                 1290             


Arg Cys  Gln Arg Ala Gly Gly  Ala Val Leu Ser Ile  Leu Asp Glu 
    1295                 1300                 1305             


Met Glu  Asn Val Phe Val Trp  Glu His Leu Gln Ser  Tyr Glu Gly 
    1310                 1315                 1320             


Gln Ser  Arg Gly Ala Trp Leu  Gly Met Asn Phe Asn  Pro Lys Gly 
    1325                 1330                 1335             


Gly Thr  Leu Val Trp Gln Asp  Asn Thr Ala Val Asn  Tyr Ser Asn 
    1340                 1345                 1350             


Trp Gly  Pro Pro Gly Leu Gly  Pro Ser Met Leu Ser  His Asn Ser 
    1355                 1360                 1365             


Cys Tyr  Trp Ile Gln Ser Asn  Ser Gly Leu Trp Arg  Pro Gly Ala 
    1370                 1375                 1380             


Cys Thr  Asn Ile Thr Met Gly  Val Val Cys Lys Leu  Pro Arg Ala 
    1385                 1390                 1395             


Glu Gln  Ser Ser Phe Ser Pro  Ser Ala Leu Pro Glu  Asn Pro Ala 
    1400                 1405                 1410             


Ala Leu  Val Val Val Leu Met  Ala Val Leu Leu Leu  Leu Ala Leu 
    1415                 1420                 1425             


Leu Thr  Ala Ala Leu Ile Leu  Tyr Arg Arg Arg Gln  Ser Ile Glu 
    1430                 1435                 1440             


Arg Gly  Ala Phe Glu Gly Ala  Arg Tyr Ser Arg Ser  Ser Ser Ser 
    1445                 1450                 1455             


Pro Thr  Glu Ala Thr Glu Lys  Asn Ile Leu Val Ser  Asp Met Glu 
    1460                 1465                 1470             


Met Asn  Glu Gln Gln Glu 
    1475                 


<210>  3
<211>  1593
<212>  DNA
<213>  Homo sapiens

<400>  3
atggggcccg gccggccggc ccccgcgccc tggcctcgtc acctgctgcg ctgcgtcctg     60

ctcctcgggt gcctgcacct cggccgtccc ggcgcccctg gggacgccgc cctcccggaa    120

cccaacgtct tcctcatctt cagccatgga ctgcagggct gcctggaggc ccagggcggg    180

caggtcagag tcaccccggc ttgcaatacc agcctccctg cccagcgctg gaagtgggtc    240

tcccgaaacc ggctattcaa cctgggtacc atgcagtgcc tgggcacagg ctggccaggc    300

accaacacca cggcctccct gggcatgtat gagtgtgacc gggaagcact gaatcttcgc    360

tggcattgtc gtacactggg tgaccagctg tccttgctcc tgggggcccg caccagcaac    420

atatccaagc ctggcaccct tgagcgtggt gaccagaccc gcagtggcca gtggcgcatc    480

tacggcagcg aggaggacct atgtgctctg ccctaccacg aggtctacac catccaggga    540

aactcccacg gaaagccgtg caccatcccc ttcaaatatg acaaccagtg gttccacggc    600

tgcaccagca cgggccgcga ggatggtcac ctgtggtgtg ccaccaccca ggactacggc    660

aaagacgagc gctggggctt ctgccccatc aagagtaacg actgcgagac cttctgggac    720

aaggaccagc tgactgacag ctgctaccag tttaacttcc agtccacgct gtcgtggagg    780

gaggcctggg ccagctgcga gcagcagggt gcggatctgc tgagcatcac ggagatccac    840

gagcagacct acatcaacgg cctcctcact gggtacagct ccaccctgtg gatcggcttg    900

aatgacttgg acacgagcgg aggctggcag tggtcggaca actcgcccct caagtacctc    960

aactgggaga gtgaccagcc ggacaacccc agtgaggaga actgtggagt gatccgcact   1020

gagtcctcgg gcggctggca gaaccgtgac tgcagcatcg cgctgcccta tgtgtgcaag   1080

aagaagccca acgccacggc cgagcccacc cctccagaca ggtgggccaa tgtgaaggtg   1140

gagtgcgagc cgagctggca gcccttccag ggccactgct accgcctgca ggccgagaag   1200

cgcagctggc aggagtccaa gaaggcatgt ctacggggcg gtggcgacct ggtcagcatc   1260

cacagcatgg cggagctgga attcatcacc aagcagatca agcaagaggt ggaggagctg   1320

tggatcggcc tcaacgattt gaaactgcag atgaattttg agtggtctga cgggagcctt   1380

gtgagcttca cccactggca cccctttgag cccaacaact tccgggacag tctggaggac   1440

tgtgtcacca tctggggccc ggaaggccgc tggaacgaca gtccctgtaa ccagtccttg   1500

ccatccatct gcaagaaggc aggccagctg agccaggggg ccgccgagga ggaccatggc   1560

tgccgggatt acaaggacga cgacgataag tga                                1593


<210>  4
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Pro Gly Arg Pro Ala Pro Ala Pro Trp Pro Arg His Leu Leu 
1               5                   10                  15      


Arg Cys Val Leu Leu Leu Gly Cys Leu His Leu Gly Arg Pro Gly Ala 
            20                  25                  30          


Pro Gly Asp Ala Ala Leu Pro Glu Pro Asn Val Phe Leu Ile Phe Ser 
        35                  40                  45              


His Gly Leu Gln Gly Cys Leu Glu Ala Gln Gly Gly Gln Val Arg Val 
    50                  55                  60                  


Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gln Arg Trp Lys Trp Val 
65                  70                  75                  80  


Ser Arg Asn Arg Leu Phe Asn Leu Gly Thr Met Gln Cys Leu Gly Thr 
                85                  90                  95      


Gly Trp Pro Gly Thr Asn Thr Thr Ala Ser Leu Gly Met Tyr Glu Cys 
            100                 105                 110         


Asp Arg Glu Ala Leu Asn Leu Arg Trp His Cys Arg Thr Leu Gly Asp 
        115                 120                 125             


Gln Leu Ser Leu Leu Leu Gly Ala Arg Thr Ser Asn Ile Ser Lys Pro 
    130                 135                 140                 


Gly Thr Leu Glu Arg Gly Asp Gln Thr Arg Ser Gly Gln Trp Arg Ile 
145                 150                 155                 160 


Tyr Gly Ser Glu Glu Asp Leu Cys Ala Leu Pro Tyr His Glu Val Tyr 
                165                 170                 175     


Thr Ile Gln Gly Asn Ser His Gly Lys Pro Cys Thr Ile Pro Phe Lys 
            180                 185                 190         


Tyr Asp Asn Gln Trp Phe His Gly Cys Thr Ser Thr Gly Arg Glu Asp 
        195                 200                 205             


Gly His Leu Trp Cys Ala Thr Thr Gln Asp Tyr Gly Lys Asp Glu Arg 
    210                 215                 220                 


Trp Gly Phe Cys Pro Ile Lys Ser Asn Asp Cys Glu Thr Phe Trp Asp 
225                 230                 235                 240 


Lys Asp Gln Leu Thr Asp Ser Cys Tyr Gln Phe Asn Phe Gln Ser Thr 
                245                 250                 255     


Leu Ser Trp Arg Glu Ala Trp Ala Ser Cys Glu Gln Gln Gly Ala Asp 
            260                 265                 270         


Leu Leu Ser Ile Thr Glu Ile His Glu Gln Thr Tyr Ile Asn Gly Leu 
        275                 280                 285             


Leu Thr Gly Tyr Ser Ser Thr Leu Trp Ile Gly Leu Asn Asp Leu Asp 
    290                 295                 300                 


Thr Ser Gly Gly Trp Gln Trp Ser Asp Asn Ser Pro Leu Lys Tyr Leu 
305                 310                 315                 320 


Asn Trp Glu Ser Asp Gln Pro Asp Asn Pro Ser Glu Glu Asn Cys Gly 
                325                 330                 335     


Val Ile Arg Thr Glu Ser Ser Gly Gly Trp Gln Asn Arg Asp Cys Ser 
            340                 345                 350         


Ile Ala Leu Pro Tyr Val Cys Lys Lys Lys Pro Asn Ala Thr Ala Glu 
        355                 360                 365             


Pro Thr Pro Pro Asp Arg Trp Ala Asn Val Lys Val Glu Cys Glu Pro 
    370                 375                 380                 


Ser Trp Gln Pro Phe Gln Gly His Cys Tyr Arg Leu Gln Ala Glu Lys 
385                 390                 395                 400 


Arg Ser Trp Gln Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly Gly Asp 
                405                 410                 415     


Leu Val Ser Ile His Ser Met Ala Glu Leu Glu Phe Ile Thr Lys Gln 
            420                 425                 430         


Ile Lys Gln Glu Val Glu Glu Leu Trp Ile Gly Leu Asn Asp Leu Lys 
        435                 440                 445             


Leu Gln Met Asn Phe Glu Trp Ser Asp Gly Ser Leu Val Ser Phe Thr 
    450                 455                 460                 


His Trp His Pro Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu Glu Asp 
465                 470                 475                 480 


Cys Val Thr Ile Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser Pro Cys 
                485                 490                 495     


Asn Gln Ser Leu Pro Ser Ile Cys Lys Lys Ala Gly Gln Leu Ser Gln 
            500                 505                 510         


Gly Ala Ala Glu Glu Asp His Gly Cys Arg Asp Tyr Lys Asp Asp Asp 
        515                 520                 525             


Asp Lys 
    530 


<210>  5
<211>  1127
<212>  DNA
<213>  Homo sapiens

<400>  5
taatgtgagt tagctactct taggcacccc aggctttaca ctttatgctt ccggctcgta     60

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt    120

acgccaagct tgccaaattc tatttcaagg agacagtcat aatgaaatac ctattgccta    180

cggcagccgc tggattgtta ttactcgcag caagcggcgc gcatgcccag gtgcagctgg    240

tgcagtctgg gggaggcctg gtcaagcctg gggggtccct gagactctcc tgtgcagcct    300

ctggattcac cttcagtagc tatagcatga actgggtccg ccaggctcca gggaaggggc    360

tggagtgggt ggccaacata aagccagatg gaagtgagag acactctgtg gactctgtga    420

agggccgatt caccatctcc agagacaact ccaagaactc actgtatctg caaatgaaca    480

gcctgagagc cgaggacacg gctgtttatt actgtgcgcg acccggggct gggcgacttg    540

actactgggg ccagggcacc ctggtcaccg tctcctcagg tggaggcggt tcaggcggag    600

gtggctctgg cggtggcgga tcgaatttta tgctgactca ggacgctgct gtgtctgtgg    660

ccttgggaca gacagtcagg atcacatgcc aaggagacag cctcagaagc tattatgcaa    720

gctggtacca acagaagcca ggacaggccc ctgtacttgt cgtctatggt aaaaacaacc    780

gaccctcagg gatcccagac cgattctctg gctccagctc aggaaacaca gcttccttga    840

ccatcactgg ggctcaggcg gaagatgagg ctgactatta ctgtaactcc cgggacagca    900

gtggtaaccc ctgggcgttc ggcggaggga ccaaggtgac cgtcctagct agcggcaaac    960

caatcccaaa cccactgctg ggcctggata gtactcacca tcaccatcac cattaggcgg   1020

ccgctactgt tgaaagttgt ttagcaaaac ctcatacaga aaattcattt actaacgtct   1080

ggaaagacga caaaacttta gatcgttacg ctaactatga gggcttg                 1127


<210>  6
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ser Gly Ala His Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Asn Ile Lys Pro Asp Gly Ser Glu Arg 
65                  70                  75                  80  


His Ser Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gly Ala Gly Arg Leu Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Phe Met Leu Thr Gln 
145                 150                 155                 160 


Asp Ala Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys 
                165                 170                 175     


Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Gln Ala Pro Val Leu Val Val Tyr Gly Lys Asn Asn Arg Pro 
        195                 200                 205             


Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala 
    210                 215                 220                 


Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
225                 230                 235                 240 


Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro Trp Ala Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Val Thr Val Leu Ala Ser Gly Lys Pro Ile Pro Asn Pro Leu 
            260                 265                 270         


Leu Gly Leu Asp Ser Thr His His His His His His 
        275                 280                 


<210>  7
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide

<400>  7

Cys Ala Arg Pro Gly Ala Gly Arg Leu Asp Tyr Trp 
1               5                   10          


<210>  8
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide

<400>  8

Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro Trp Ala Phe 
1               5                   10              


<210>  9
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Pro Gly Arg Pro Ala Pro Ala Pro Trp Pro Arg His Leu Leu 
1               5                   10                  15      


Arg Cys Val Leu Leu Leu Gly Cys Leu His Leu Gly Arg Pro Gly Ala 
            20                  25                  30          


Pro Gly Asp Ala Ala Leu Pro Glu Pro Asn Val Phe Leu Ile Phe Ser 
        35                  40                  45              


His Gly Leu Gln Gly Cys Leu Glu Ala Gln Gly Gly Gln Val Arg Val 
    50                  55                  60                  


Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gln Arg Trp Lys Trp Val 
65                  70                  75                  80  


Ser Arg Asn Arg Leu Phe Asn Leu Gly Thr Met Gln Cys Leu Gly Thr 
                85                  90                  95      


Gly Trp Pro Gly Thr Asn Thr Thr Ala Ser Leu Gly Met Tyr Glu Cys 
            100                 105                 110         


Asp Arg Glu Ala Leu Asn Leu Arg Trp His Cys Arg Thr Leu Gly Asp 
        115                 120                 125             


Gln Leu Ser Leu Leu Leu Gly Ala Arg Thr Ser Asn Ile Ser Lys Pro 
    130                 135                 140                 


Gly Thr Leu Glu Arg Gly Asp Gln Thr Arg Ser Gly Gln Trp Arg Ile 
145                 150                 155                 160 


Tyr Gly Ser Glu Glu Asp Leu Cys Ala Leu Pro Tyr His Glu Val Tyr 
                165                 170                 175     


Thr Ile Gln Gly Asn Ser His Gly Lys Pro Cys Thr Ile Pro Phe Lys 
            180                 185                 190         


Tyr Asp Asn Gln Trp Phe His Gly Cys Thr Ser Thr Gly Arg Glu Asp 
        195                 200                 205             


Gly His Leu Trp Cys Ala Thr Thr Gln Asp Tyr Gly Lys Asp Glu Arg 
    210                 215                 220                 


Trp Gly Phe Cys Pro Ile Lys Ser Asn Asp Cys Glu Thr Phe Trp Asp 
225                 230                 235                 240 


Lys Asp Gln Leu Thr Asp Ser Cys Tyr Gln Phe Asn Phe Gln Ser Thr 
                245                 250                 255     


Leu Ser Trp Arg Glu Ala Trp Ala Ser Cys Glu Gln Gln Gly Ala Asp 
            260                 265                 270         


Leu Leu Ser Ile Thr Glu Ile His Glu Gln Thr Tyr Ile Asn Gly Leu 
        275                 280                 285             


Leu Thr Gly Tyr Ser Ser Thr Leu Trp Ile Gly Leu Asn Asp Leu Asp 
    290                 295                 300                 


Thr Ser Gly Gly Trp Gln Trp Ser Asp Asn Ser Pro Leu Lys Tyr Leu 
305                 310                 315                 320 


Asn Trp Glu Ser Asp Gln Pro Asp Asn Pro Ser Glu Glu Asn Cys Gly 
                325                 330                 335     


Val Ile Arg Thr Glu Ser Ser Gly Gly Trp Gln Asn Arg Asp Cys Ser 
            340                 345                 350         


Ile Ala Leu Pro Tyr Val Cys Lys Lys Lys Pro Asn Ala Thr Ala Glu 
        355                 360                 365             


Pro Thr Pro Pro Asp Arg Trp Ala Asn Val Lys Val Glu Cys Glu Pro 
    370                 375                 380                 


Ser Trp Gln Pro Phe Gln Gly His Cys Tyr Arg Leu Gln Ala Glu Lys 
385                 390                 395                 400 


Arg Ser Trp Gln Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly Gly Asp 
                405                 410                 415     


Leu Val Ser Ile His Ser Met Ala Glu Leu Glu Phe Ile Thr Lys Gln 
            420                 425                 430         


Ile Lys Gln Glu Val Glu Glu Leu Trp Ile Gly Leu Asn Asp Leu Lys 
        435                 440                 445             


Leu Gln Met Asn Phe Glu Trp Ser Asp Gly Ser Leu Val Ser Phe Thr 
    450                 455                 460                 


His Trp His Pro Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu Glu Asp 
465                 470                 475                 480 


Cys Val Thr Ile Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser Pro Cys 
                485                 490                 495     


Asn Gln Ser Leu Pro Ser Ile Cys Lys Lys Ala Gly Gln Leu Ser Gln 
            500                 505                 510         


Gly Ala Ala Glu Glu Asp His Gly Cys Arg 
        515                 520         


