
SEQUENCE LISTING

<110> AGENSYS, INC.
      SEATTLE GENETICS
      GUDAS, Jean
      JAKOBOVITS, Aya
      AN, Zili
      MORRISON, Robert Kendall
      MORRISON, Karen Jane Meyrick
      JIA, Xiao-chi
      BENJAMIN, Dennis
      MOSER, Ruth
      SENTER, Peter

<120> ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 24P4C12 PROTEINS

<130> 511582001165

<140> PCT/US2010/026429   
<141> 2010-03-05  

<150> US 61/158,143       
<151> 2009-03-06  

<160> 25

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2587
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(2587)
<223> 24P4C12 variant 1

<220> 
<221> CDS            
<222> (6)...(2138)

<400> 1
gagcc atg ggg gga aag cag cgg gac gag gat gac gag gcc tac ggg aag 50
      Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys
       1               5                   10                  15
 
cca gtc aaa tac gac ccc tcc ttt cga ggc ccc atc aag aac aga agc   98
Pro Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser
                 20                  25                  30
 
tgc aca gat gtc atc tgc tgc gtc ctc ttc ctg ctc ttc att cta ggt   146
Cys Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly
             35                  40                  45
 
tac atc gtg gtg ggg att gtg gcc tgg ttg tat gga gac ccc cgg caa   194
Tyr Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln
         50                  55                  60
 
gtc ctc tac ccc agg aac tct act ggg gcc tac tgt ggc atg ggg gag   242
Val Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu
     65                  70                  75
 
aac aaa gat aag ccg tat ctc ctg tac ttc aac atc ttc agc tgc atc   290
Asn Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile
 80                  85                  90                  95
 
ctg tcc agc aac atc atc tca gtt gct gag aac ggc cta cag tgc ccc   338
Leu Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro
                100                 105                 110
 
aca ccc cag gtg tgt gtg tcc tcc tgc ccg gag gac cca tgg act gtg   386
Thr Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val
            115                 120                 125
 
gga aaa aac gag ttc tca cag act gtt ggg gaa gtc ttc tat aca aaa   434
Gly Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys
        130                 135                 140
 
aac agg aac ttt tgt ctg cca ggg gta ccc tgg aat atg acg gtg atc   482
Asn Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile
    145                 150                 155
 
aca agc ctg caa cag gaa ctc tgc ccc agt ttc ctc ctc ccc tct gct   530
Thr Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala
160                 165                 170                 175
 
cca gct ctg ggg cgc tgc ttt cca tgg acc aac gtt act cca ccg gcg   578
Pro Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala
                180                 185                 190
 
ctc cca ggg atc acc aat gac acc acc ata cag cag ggg atc agc ggt   626
Leu Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly
            195                 200                 205
 
ctt att gac agc ctc aat gcc cga gac atc agt gtt aag atc ttt gaa   674
Leu Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu
        210                 215                 220
 
gat ttt gcc cag tcc tgg tat tgg att ctt gtt gcc ctg ggg gtg gct   722
Asp Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala
    225                 230                 235
 
ctg gtc ttg agc cta ctg ttt atc ttg ctt ctg cgc ctg gtg gct ggg   770
Leu Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly
240                 245                 250                 255
 
ccc ctg gtg ctg gtg ctg atc ctg gga gtg ctg ggc gtg ctg gca tac   818
Pro Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr
                260                 265                 270
 
ggc atc tac tac tgc tgg gag gag tac cga gtg ctg cgg gac aag ggc   866
Gly Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly
            275                 280                 285
 
gcc tcc atc tcc cag ctg ggt ttc acc acc aac ctc agt gcc tac cag   914
Ala Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln
        290                 295                 300
 
agc gtg cag gag acc tgg ctg gcc gcc ctg atc gtg ttg gcg gtg ctt   962
Ser Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu
    305                 310                 315
 
gaa gcc atc ctg ctg ctg atg ctc atc ttc ctg cgg cag cgg att cgt   1010
Glu Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg
320                 325                 330                 335
 
att gcc atc gcc ctc ctg aag gag gcc agc aag gct gtg gga cag atg   1058
Ile Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met
                340                 345                 350
 
atg tct acc atg ttc tac cca ctg gtc acc ttt gtc ctc ctc ctc atc   1106
Met Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile
            355                 360                 365
 
tgc att gcc tac tgg gcc atg act gct ctg tac ctg gct aca tcg ggg   1154
Cys Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly
        370                 375                 380
 
caa ccc cag tat gtg ctc tgg gca tcc aac atc agc tcc ccc ggc tgt   1202
Gln Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys
    385                 390                 395
 
gag aaa gtg cca ata aat aca tca tgc aac ccc acg gcc cac ctt gtg   1250
Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val
400                 405                 410                 415
 
aac tcc tcg tgc cca ggg ctg atg tgc gtc ttc cag ggc tac tca tcc   1298
Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser
                420                 425                 430
 
aaa ggc cta atc caa cgt tct gtc ttc aat ctg caa atc tat ggg gtc   1346
Lys Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val
            435                 440                 445
 
ctg ggg ctc ttc tgg acc ctt aac tgg gta ctg gcc ctg ggc caa tgc   1394
Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys
        450                 455                 460
 
gtc ctc gct gga gcc ttt gcc tcc ttc tac tgg gcc ttc cac aag ccc   1442
Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro
    465                 470                 475
 
cag gac atc cct acc ttc ccc tta atc tct gcc ttc atc cgc aca ctc   1490
Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu
480                 485                 490                 495
 
cgt tac cac act ggg tca ttg gca ttt gga gcc ctc atc ctg acc ctt   1538
Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu
                500                 505                 510
 
gtg cag ata gcc cgg gtc atc ttg gag tat att gac cac aag ctc aga   1586
Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg
            515                 520                 525
 
gga gtg cag aac cct gta gcc cgc tgc atc atg tgc tgt ttc aag tgc   1634
Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys
        530                 535                 540
 
tgc ctc tgg tgt ctg gaa aaa ttt atc aag ttc cta aac cgc aat gca   1682
Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala
    545                 550                 555
 
tac atc atg atc gcc atc tac ggg aag aat ttc tgt gtc tca gcc aaa   1730
Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys
560                 565                 570                 575
 
aat gcg ttc atg cta ctc atg cga aac att gtc agg gtg gtc gtc ctg   1778
Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu
                580                 585                 590
 
gac aaa gtc aca gac ctg ctg ctg ttc ttt ggg aag ctg ctg gtg gtc   1826
Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val
            595                 600                 605
 
gga ggc gtg ggg gtc ctg tcc ttc ttt ttt ttc tcc ggt cgc atc ccg   1874
Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro
        610                 615                 620
 
ggg ctg ggt aaa gac ttt aag agc ccc cac ctc aac tat tac tgg ctg   1922
Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu
    625                 630                 635
 
ccc atc atg acc tcc atc ctg ggg gcc tat gtc atc gcc agc ggc ttc   1970
Pro Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe
640                 645                 650                 655
 
ttc agc gtt ttc ggc atg tgt gtg gac acg ctc ttc ctc tgc ttc ctg   2018
Phe Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu
                660                 665                 670
 
gaa gac ctg gag cgg aac aac ggc tcc ctg gac cgg ccc tac tac atg   2066
Glu Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met
            675                 680                 685
 
tcc aag agc ctt cta aag att ctg ggc aag aag aac gag gcg ccc ccg   2114
Ser Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro
        690                 695                 700
 
gac aac aag aag agg aag aag tga cagctccggc cctgatccag gactgcaccc  2168
Asp Asn Lys Lys Arg Lys Lys  *
    705                 710
 
cacccccacc gtccagccat ccaacctcac ttcgccttac aggtctccat tttgtggtaa 2228
aaaaaggttt taggccaggc gccgtggctc acgcctgtaa tccaacactt tgagaggctg 2288
aggcgggcgg atcacctgag tcaggagttc gagaccagcc tggccaacat ggtgaaacct 2348
ccgtctctat taaaaataca aaaattagcc gagagtggtg gcatgcacct gtcatcccag 2408
ctactcggga ggctgaggca ggagaatcgc ttgaacccgg gaggcagagg ttgcagtgag 2468
ccgagatcgc gccactgcac tccaacctgg gtgacagact ctgtctccaa aacaaaacaa 2528
acaaacaaaa agattttatt aaagatattt tgttaactca gtaaaaaaaa aaaaaaaaa  2587

<210> 2
<211> 710
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(710)
<223> 24P4C12 variant 1 coding sequence

<400> 2
Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro
 1               5                  10                  15      
Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys
            20                  25                  30          
Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr
        35                  40                  45              
Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val
    50                  55                  60                  
Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn
65                  70                  75                  80  
Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
                85                  90                  95      
Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
            100                 105                 110         
Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
        115                 120                 125             
Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn
    130                 135                 140                 
Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
145                 150                 155                 160 
Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
                165                 170                 175     
Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala Leu
            180                 185                 190         
Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
        195                 200                 205             
Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
    210                 215                 220                 
Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu
225                 230                 235                 240 
Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro
                245                 250                 255     
Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly
            260                 265                 270         
Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala
        275                 280                 285             
Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser
    290                 295                 300                 
Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu
305                 310                 315                 320 
Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile
                325                 330                 335     
Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met
            340                 345                 350         
Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys
        355                 360                 365             
Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly Gln
    370                 375                 380                 
Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys Glu
385                 390                 395                 400 
Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val Asn
                405                 410                 415     
Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser Lys
            420                 425                 430         
Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val Leu
        435                 440                 445             
Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys Val
    450                 455                 460                 
Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro Gln
465                 470                 475                 480 
Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu Arg
                485                 490                 495     
Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu Val
            500                 505                 510         
Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg Gly
        515                 520                 525             
Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys Cys
    530                 535                 540                 
Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr
545                 550                 555                 560 
Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys Asn
                565                 570                 575     
Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu Asp
            580                 585                 590         
Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val Gly
        595                 600                 605             
Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro Gly
    610                 615                 620                 
Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu Pro
625                 630                 635                 640 
Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe
                645                 650                 655     
Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu
            660                 665                 670         
Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser
        675                 680                 685             
Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp
    690                 695                 700                 
Asn Lys Lys Arg Lys Lys
705                 710 


<210> 3
<211> 2587
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(2587)
<223> 24P4C12 variant 2

<220> 
<221> CDS            
<222> (6)...(2138)

<400> 3
gagcc atg ggg gga aag cag cgg gac gag gat gac gag gcc tac ggg aag 50
      Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys
       1               5                   10                  15
 
cca gtc aaa tac gac ccc tcc ttt cga ggc ccc atc aag aac aga agc   98
Pro Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser
                 20                  25                  30
 
tgc aca gat gtc atc tgc tgc gtc ctc ttc ctg ctc ttc att cta ggt   146
Cys Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly
             35                  40                  45
 
tac atc gtg gtg ggg att gtg gcc tgg ttg tat gga gac ccc cgg caa   194
Tyr Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln
         50                  55                  60
 
gtc ctc tac ccc agg aac tct act ggg gcc tac tgt ggc atg ggg gag   242
Val Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu
     65                  70                  75
 
aac aaa gat aag ccg tat ctc ctg tac ttc aac atc ttc agc tgc atc   290
Asn Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile
 80                  85                  90                  95
 
ctg tcc agc aac atc atc tca gtt gct gag aac ggc cta cag tgc ccc   338
Leu Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro
                100                 105                 110
 
aca ccc cag gtg tgt gtg tcc tcc tgc ccg gag gac cca tgg act gtg   386
Thr Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val
            115                 120                 125
 
gga aaa aac gag ttc tca cag act gtt ggg gaa gtc ttc tat aca aaa   434
Gly Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys
        130                 135                 140
 
aac agg aac ttt tgt ctg cca ggg gta ccc tgg aat atg acg gtg atc   482
Asn Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile
    145                 150                 155
 
aca agc ctg caa cag gaa ctc tgc ccc agt ttc ctc ctc ccc tct gct   530
Thr Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala
160                 165                 170                 175
 
cca gct ctg gga cgc tgc ttt cca tgg acc aac gtt act cca ccg gcg   578
Pro Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala
                180                 185                 190
 
ctc cca ggg atc acc aat gac acc acc ata cag cag ggg atc agc ggt   626
Leu Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly
            195                 200                 205
 
ctt att gac agc ctc aat gcc cga gac atc agt gtt aag atc ttt gaa   674
Leu Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu
        210                 215                 220
 
gat ttt gcc cag tcc tgg tat tgg att ctt gtt gcc ctg ggg gtg gct   722
Asp Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala
    225                 230                 235
 
ctg gtc ttg agc cta ctg ttt atc ttg ctt ctg cgc ctg gtg gct ggg   770
Leu Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly
240                 245                 250                 255
 
ccc ctg gtg ctg gtg ctg atc ctg gga gtg ctg ggc gtg ctg gca tac   818
Pro Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr
                260                 265                 270
 
ggc atc tac tac tgc tgg gag gag tac cga gtg ctg cgg gac aag ggc   866
Gly Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly
            275                 280                 285
 
gcc tcc atc tcc cag ctg ggt ttc acc acc aac ctc agt gcc tac cag   914
Ala Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln
        290                 295                 300
 
agc gtg cag gag acc tgg ctg gcc gcc ctg atc gtg ttg gcg gtg ctt   962
Ser Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu
    305                 310                 315
 
gaa gcc atc ctg ctg ctg atg ctc atc ttc ctg cgg cag cgg att cgt   1010
Glu Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg
320                 325                 330                 335
 
att gcc atc gcc ctc ctg aag gag gcc agc aag gct gtg gga cag atg   1058
Ile Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met
                340                 345                 350
 
atg tct acc atg ttc tac cca ctg gtc acc ttt gtc ctc ctc ctc atc   1106
Met Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile
            355                 360                 365
 
tgc att gcc tac tgg gcc atg act gct ctg tac ctg gct aca tcg ggg   1154
Cys Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly
        370                 375                 380
 
caa ccc cag tat gtg ctc tgg gca tcc aac atc agc tcc ccc ggc tgt   1202
Gln Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys
    385                 390                 395
 
gag aaa gtg cca ata aat aca tca tgc aac ccc acg gcc cac ctt gtg   1250
Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val
400                 405                 410                 415
 
aac tcc tcg tgc cca ggg ctg atg tgc gtc ttc cag ggc tac tca tcc   1298
Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser
                420                 425                 430
 
aaa ggc cta atc caa cgt tct gtc ttc aat ctg caa atc tat ggg gtc   1346
Lys Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val
            435                 440                 445
 
ctg ggg ctc ttc tgg acc ctt aac tgg gta ctg gcc ctg ggc caa tgc   1394
Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys
        450                 455                 460
 
gtc ctc gct gga gcc ttt gcc tcc ttc tac tgg gcc ttc cac aag ccc   1442
Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro
    465                 470                 475
 
cag gac atc cct acc ttc ccc tta atc tct gcc ttc atc cgc aca ctc   1490
Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu
480                 485                 490                 495
 
cgt tac cac act ggg tca ttg gca ttt gga gcc ctc atc ctg acc ctt   1538
Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu
                500                 505                 510
 
gtg cag ata gcc cgg gtc atc ttg gag tat att gac cac aag ctc aga   1586
Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg
            515                 520                 525
 
gga gtg cag aac cct gta gcc cgc tgc atc atg tgc tgt ttc aag tgc   1634
Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys
        530                 535                 540
 
tgc ctc tgg tgt ctg gaa aaa ttt atc aag ttc cta aac cgc aat gca   1682
Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala
    545                 550                 555
 
tac atc atg atc gcc atc tac ggg aag aat ttc tgt gtc tca gcc aaa   1730
Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys
560                 565                 570                 575
 
aat gcg ttc atg cta ctc atg cga aac att gtc agg gtg gtc gtc ctg   1778
Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu
                580                 585                 590
 
gac aaa gtc aca gac ctg ctg ctg ttc ttt ggg aag ctg ctg gtg gtc   1826
Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val
            595                 600                 605
 
gga ggc gtg ggg gtc ctg tcc ttc ttt ttt ttc tcc ggt cgc atc ccg   1874
Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro
        610                 615                 620
 
ggg ctg ggt aaa gac ttt aag agc ccc cac ctc aac tat tac tgg ctg   1922
Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu
    625                 630                 635
 
ccc atc atg acc tcc atc ctg ggg gcc tat gtc atc gcc agc ggc ttc   1970
Pro Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe
640                 645                 650                 655
 
ttc agc gtt ttc ggc atg tgt gtg gac acg ctc ttc ctc tgc ttc ctg   2018
Phe Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu
                660                 665                 670
 
gaa gac ctg gag cgg aac aac ggc tcc ctg gac cgg ccc tac tac atg   2066
Glu Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met
            675                 680                 685
 
tcc aag agc ctt cta aag att ctg ggc aag aag aac gag gcg ccc ccg   2114
Ser Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro
        690                 695                 700
 
gac aac aag aag agg aag aag tga cagctccggc cctgatccag gactgcaccc  2168
Asp Asn Lys Lys Arg Lys Lys  *
    705                 710
 
cacccccacc gtccagccat ccaacctcac ttcgccttac aggtctccat tttgtggtaa 2228
aaaaaggttt taggccaggc gccgtggctc acgcctgtaa tccaacactt tgagaggctg 2288
aggcgggcgg atcacctgag tcaggagttc gagaccagcc tggccaacat ggtgaaacct 2348
ccgtctctat taaaaataca aaaattagcc gagagtggtg gcatgcacct gtcatcccag 2408
ctactcggga ggctgaggca ggagaatcgc ttgaacccgg gaggcagagg ttgcagtgag 2468
ccgagatcgc gccactgcac tccaacctgg gtgacagact ctgtctccaa aacaaaacaa 2528
acaaacaaaa agattttatt aaagatattt tgttaactca gtaaaaaaaa aaaaaaaaa  2587

<210> 4
<211> 710
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(710)
<223> 24P4C12 variant 2 coding sequence

<400> 4
Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro
 1               5                  10                  15      
Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys
            20                  25                  30          
Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr
        35                  40                  45              
Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val
    50                  55                  60                  
Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn
65                  70                  75                  80  
Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
                85                  90                  95      
Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
            100                 105                 110         
Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
        115                 120                 125             
Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn
    130                 135                 140                 
Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
145                 150                 155                 160 
Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
                165                 170                 175     
Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala Leu
            180                 185                 190         
Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
        195                 200                 205             
Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
    210                 215                 220                 
Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu
225                 230                 235                 240 
Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro
                245                 250                 255     
Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly
            260                 265                 270         
Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala
        275                 280                 285             
Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser
    290                 295                 300                 
Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu
305                 310                 315                 320 
Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile
                325                 330                 335     
Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met
            340                 345                 350         
Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys
        355                 360                 365             
Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly Gln
    370                 375                 380                 
Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys Glu
385                 390                 395                 400 
Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val Asn
                405                 410                 415     
Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser Lys
            420                 425                 430         
Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val Leu
        435                 440                 445             
Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys Val
    450                 455                 460                 
Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro Gln
465                 470                 475                 480 
Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu Arg
                485                 490                 495     
Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu Val
            500                 505                 510         
Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg Gly
        515                 520                 525             
Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys Cys
    530                 535                 540                 
Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr
545                 550                 555                 560 
Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys Asn
                565                 570                 575     
Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu Asp
            580                 585                 590         
Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val Gly
        595                 600                 605             
Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro Gly
    610                 615                 620                 
Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu Pro
625                 630                 635                 640 
Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe
                645                 650                 655     
Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu
            660                 665                 670         
Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser
        675                 680                 685             
Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp
    690                 695                 700                 
Asn Lys Lys Arg Lys Lys
705                 710 


<210> 5
<211> 2587
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(2587)
<223> 24P4C12 variant 3

<220> 
<221> CDS            
<222> (6)...(2138)

<400> 5
gagcc atg ggg gga aag cag cgg gac gag gat gac gag gcc tac ggg aag 50
      Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys
       1               5                   10                  15
 
cca gtc aaa tac gac ccc tcc ttt cga ggc ccc atc aag aac aga agc   98
Pro Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser
                 20                  25                  30
 
tgc aca gat gtc atc tgc tgc gtc ctc ttc ctg ctc ttc att cta ggt   146
Cys Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly
             35                  40                  45
 
tac atc gtg gtg ggg att gtg gcc tgg ttg tat gga gac ccc cgg caa   194
Tyr Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln
         50                  55                  60
 
gtc ctc tac ccc agg aac tct act ggg gcc tac tgt ggc atg ggg gag   242
Val Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu
     65                  70                  75
 
aac aaa gat aag ccg tat ctc ctg tac ttc aac atc ttc agc tgc atc   290
Asn Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile
 80                  85                  90                  95
 
ctg tcc agc aac atc atc tca gtt gct gag aac ggc cta cag tgc ccc   338
Leu Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro
                100                 105                 110
 
aca ccc cag gtg tgt gtg tcc tcc tgc ccg gag gac cca tgg act gtg   386
Thr Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val
            115                 120                 125
 
gga aaa aac gag ttc tca cag act gtt ggg gaa gtc ttc tat aca aaa   434
Gly Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys
        130                 135                 140
 
aac agg aac ttt tgt ctg cca ggg gta ccc tgg aat atg acg gtg atc   482
Asn Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile
    145                 150                 155
 
aca agc ctg caa cag gaa ctc tgc ccc agt ttc ctc ctc ccc tct gct   530
Thr Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala
160                 165                 170                 175
 
cca gct ctg ggg cgc tgc ttt cca tgg acc aac att act cca ccg gcg   578
Pro Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Ile Thr Pro Pro Ala
                180                 185                 190
 
ctc cca ggg atc acc aat gac acc acc ata cag cag ggg atc agc ggt   626
Leu Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly
            195                 200                 205
 
ctt att gac agc ctc aat gcc cga gac atc agt gtt aag atc ttt gaa   674
Leu Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu
        210                 215                 220
 
gat ttt gcc cag tcc tgg tat tgg att ctt gtt gcc ctg ggg gtg gct   722
Asp Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala
    225                 230                 235
 
ctg gtc ttg agc cta ctg ttt atc ttg ctt ctg cgc ctg gtg gct ggg   770
Leu Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly
240                 245                 250                 255
 
ccc ctg gtg ctg gtg ctg atc ctg gga gtg ctg ggc gtg ctg gca tac   818
Pro Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr
                260                 265                 270
 
ggc atc tac tac tgc tgg gag gag tac cga gtg ctg cgg gac aag ggc   866
Gly Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly
            275                 280                 285
 
gcc tcc atc tcc cag ctg ggt ttc acc acc aac ctc agt gcc tac cag   914
Ala Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln
        290                 295                 300
 
agc gtg cag gag acc tgg ctg gcc gcc ctg atc gtg ttg gcg gtg ctt   962
Ser Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu
    305                 310                 315
 
gaa gcc atc ctg ctg ctg atg ctc atc ttc ctg cgg cag cgg att cgt   1010
Glu Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg
320                 325                 330                 335
 
att gcc atc gcc ctc ctg aag gag gcc agc aag gct gtg gga cag atg   1058
Ile Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met
                340                 345                 350
 
atg tct acc atg ttc tac cca ctg gtc acc ttt gtc ctc ctc ctc atc   1106
Met Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile
            355                 360                 365
 
tgc att gcc tac tgg gcc atg act gct ctg tac ctg gct aca tcg ggg   1154
Cys Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly
        370                 375                 380
 
caa ccc cag tat gtg ctc tgg gca tcc aac atc agc tcc ccc ggc tgt   1202
Gln Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys
    385                 390                 395
 
gag aaa gtg cca ata aat aca tca tgc aac ccc acg gcc cac ctt gtg   1250
Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val
400                 405                 410                 415
 
aac tcc tcg tgc cca ggg ctg atg tgc gtc ttc cag ggc tac tca tcc   1298
Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser
                420                 425                 430
 
aaa ggc cta atc caa cgt tct gtc ttc aat ctg caa atc tat ggg gtc   1346
Lys Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val
            435                 440                 445
 
ctg ggg ctc ttc tgg acc ctt aac tgg gta ctg gcc ctg ggc caa tgc   1394
Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys
        450                 455                 460
 
gtc ctc gct gga gcc ttt gcc tcc ttc tac tgg gcc ttc cac aag ccc   1442
Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro
    465                 470                 475
 
cag gac atc cct acc ttc ccc tta atc tct gcc ttc atc cgc aca ctc   1490
Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu
480                 485                 490                 495
 
cgt tac cac act ggg tca ttg gca ttt gga gcc ctc atc ctg acc ctt   1538
Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu
                500                 505                 510
 
gtg cag ata gcc cgg gtc atc ttg gag tat att gac cac aag ctc aga   1586
Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg
            515                 520                 525
 
gga gtg cag aac cct gta gcc cgc tgc atc atg tgc tgt ttc aag tgc   1634
Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys
        530                 535                 540
 
tgc ctc tgg tgt ctg gaa aaa ttt atc aag ttc cta aac cgc aat gca   1682
Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala
    545                 550                 555
 
tac atc atg atc gcc atc tac ggg aag aat ttc tgt gtc tca gcc aaa   1730
Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys
560                 565                 570                 575
 
aat gcg ttc atg cta ctc atg cga aac att gtc agg gtg gtc gtc ctg   1778
Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu
                580                 585                 590
 
gac aaa gtc aca gac ctg ctg ctg ttc ttt ggg aag ctg ctg gtg gtc   1826
Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val
            595                 600                 605
 
gga ggc gtg ggg gtc ctg tcc ttc ttt ttt ttc tcc ggt cgc atc ccg   1874
Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro
        610                 615                 620
 
ggg ctg ggt aaa gac ttt aag agc ccc cac ctc aac tat tac tgg ctg   1922
Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu
    625                 630                 635
 
ccc atc atg acc tcc atc ctg ggg gcc tat gtc atc gcc agc ggc ttc   1970
Pro Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe
640                 645                 650                 655
 
ttc agc gtt ttc ggc atg tgt gtg gac acg ctc ttc ctc tgc ttc ctg   2018
Phe Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu
                660                 665                 670
 
gaa gac ctg gag cgg aac aac ggc tcc ctg gac cgg ccc tac tac atg   2066
Glu Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met
            675                 680                 685
 
tcc aag agc ctt cta aag att ctg ggc aag aag aac gag gcg ccc ccg   2114
Ser Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro
        690                 695                 700
 
gac aac aag aag agg aag aag tga cagctccggc cctgatccag gactgcaccc  2168
Asp Asn Lys Lys Arg Lys Lys  *
    705                 710
 
cacccccacc gtccagccat ccaacctcac ttcgccttac aggtctccat tttgtggtaa 2228
aaaaaggttt taggccaggc gccgtggctc acgcctgtaa tccaacactt tgagaggctg 2288
aggcgggcgg atcacctgag tcaggagttc gagaccagcc tggccaacat ggtgaaacct 2348
ccgtctctat taaaaataca aaaattagcc gagagtggtg gcatgcacct gtcatcccag 2408
ctactcggga ggctgaggca ggagaatcgc ttgaacccgg gaggcagagg ttgcagtgag 2468
ccgagatcgc gccactgcac tccaacctgg gtgacagact ctgtctccaa aacaaaacaa 2528
acaaacaaaa agattttatt aaagatattt tgttaactca gtaaaaaaaa aaaaaaaaa  2587

<210> 6
<211> 710
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(710)
<223> 24P4C12 variant 3 coding sequence

<400> 6
Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro
 1               5                  10                  15      
Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys
            20                  25                  30          
Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr
        35                  40                  45              
Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val
    50                  55                  60                  
Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn
65                  70                  75                  80  
Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
                85                  90                  95      
Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
            100                 105                 110         
Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
        115                 120                 125             
Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn
    130                 135                 140                 
Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
145                 150                 155                 160 
Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
                165                 170                 175     
Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Ile Thr Pro Pro Ala Leu
            180                 185                 190         
Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
        195                 200                 205             
Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
    210                 215                 220                 
Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu
225                 230                 235                 240 
Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro
                245                 250                 255     
Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly
            260                 265                 270         
Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala
        275                 280                 285             
Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser
    290                 295                 300                 
Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu
305                 310                 315                 320 
Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile
                325                 330                 335     
Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met
            340                 345                 350         
Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys
        355                 360                 365             
Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly Gln
    370                 375                 380                 
Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys Glu
385                 390                 395                 400 
Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val Asn
                405                 410                 415     
Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser Lys
            420                 425                 430         
Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val Leu
        435                 440                 445             
Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys Val
    450                 455                 460                 
Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro Gln
465                 470                 475                 480 
Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu Arg
                485                 490                 495     
Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu Val
            500                 505                 510         
Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg Gly
        515                 520                 525             
Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys Cys
    530                 535                 540                 
Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr
545                 550                 555                 560 
Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys Asn
                565                 570                 575     
Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu Asp
            580                 585                 590         
Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val Gly
        595                 600                 605             
Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro Gly
    610                 615                 620                 
Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu Pro
625                 630                 635                 640 
Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe
                645                 650                 655     
Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu
            660                 665                 670         
Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser
        675                 680                 685             
Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp
    690                 695                 700                 
Asn Lys Lys Arg Lys Lys
705                 710 


<210> 7
<211> 2587
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(2587)
<223> 24P4C12 variant 4

<220> 
<221> CDS            
<222> (6)...(2138)

<400> 7
gagcc atg ggg gga aag cag cgg gac gag gat gac gag gcc tac ggg aag 50
      Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys
       1               5                   10                  15
 
cca gtc aaa tac gac ccc tcc ttt cga ggc ccc atc aag aac aga agc   98
Pro Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser
                 20                  25                  30
 
tgc aca gat gtc atc tgc tgc gtc ctc ttc ctg ctc ttc att cta ggt   146
Cys Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly
             35                  40                  45
 
tac atc gtg gtg ggg att gtg gcc tgg ttg tat gga gac ccc cgg caa   194
Tyr Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln
         50                  55                  60
 
gtc ctc tac ccc agg aac tct act ggg gcc tac tgt ggc atg ggg gag   242
Val Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu
     65                  70                  75
 
aac aaa gat aag ccg tat ctc ctg tac ttc aac atc ttc agc tgc atc   290
Asn Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile
 80                  85                  90                  95
 
ctg tcc agc aac atc atc tca gtt gct gag aac ggc cta cag tgc ccc   338
Leu Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro
                100                 105                 110
 
aca ccc cag gtg tgt gtg tcc tcc tgc ccg gag gac cca tgg act gtg   386
Thr Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val
            115                 120                 125
 
gga aaa aac gag ttc tca cag act gtt ggg gaa gtc ttc tat aca aaa   434
Gly Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys
        130                 135                 140
 
aac agg aac ttt tgt ctg cca ggg gta ccc tgg aat atg acg gtg atc   482
Asn Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile
    145                 150                 155
 
aca agc ctg caa cag gaa ctc tgc ccc agt ttc ctc ctc ccc tct gct   530
Thr Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala
160                 165                 170                 175
 
cca gct ctg ggg cgc tgc ttt cca tgg acc aac gtt act cca ccg gcg   578
Pro Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala
                180                 185                 190
 
ctc cca ggg atc acc aat gac acc acc ata cag cag ggg atc agc ggt   626
Leu Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly
            195                 200                 205
 
ctt att gac agc ctc aat gcc cga gac atc agt gtt aag atc ttt gaa   674
Leu Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu
        210                 215                 220
 
gat ttt gcc cag tcc tgg tat tgg att ctt gtt gcc ctg ggg gtg gct   722
Asp Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala
    225                 230                 235
 
ctg gtc ttg agc cta ctg ttt atc ttg ctt ctg cgc ctg gtg gct ggg   770
Leu Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly
240                 245                 250                 255
 
ccc ctg gtg ctg gtg ctg atc ctg gga gtg ctg ggc gtg ctg gca tat   818
Pro Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr
                260                 265                 270
 
ggc atc tac tac tgc tgg gag gag tac cga gtg ctg cgg gac aag ggc   866
Gly Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly
            275                 280                 285
 
gcc tcc atc tcc cag ctg ggt ttc acc acc aac ctc agt gcc tac cag   914
Ala Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln
        290                 295                 300
 
agc gtg cag gag acc tgg ctg gcc gcc ctg atc gtg ttg gcg gtg ctt   962
Ser Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu
    305                 310                 315
 
gaa gcc atc ctg ctg ctg atg ctc atc ttc ctg cgg cag cgg att cgt   1010
Glu Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg
320                 325                 330                 335
 
att gcc atc gcc ctc ctg aag gag gcc agc aag gct gtg gga cag atg   1058
Ile Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met
                340                 345                 350
 
atg tct acc atg ttc tac cca ctg gtc acc ttt gtc ctc ctc ctc atc   1106
Met Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile
            355                 360                 365
 
tgc att gcc tac tgg gcc atg act gct ctg tac ctg gct aca tcg ggg   1154
Cys Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly
        370                 375                 380
 
caa ccc cag tat gtg ctc tgg gca tcc aac atc agc tcc ccc ggc tgt   1202
Gln Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys
    385                 390                 395
 
gag aaa gtg cca ata aat aca tca tgc aac ccc acg gcc cac ctt gtg   1250
Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val
400                 405                 410                 415
 
aac tcc tcg tgc cca ggg ctg atg tgc gtc ttc cag ggc tac tca tcc   1298
Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser
                420                 425                 430
 
aaa ggc cta atc caa cgt tct gtc ttc aat ctg caa atc tat ggg gtc   1346
Lys Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val
            435                 440                 445
 
ctg ggg ctc ttc tgg acc ctt aac tgg gta ctg gcc ctg ggc caa tgc   1394
Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys
        450                 455                 460
 
gtc ctc gct gga gcc ttt gcc tcc ttc tac tgg gcc ttc cac aag ccc   1442
Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro
    465                 470                 475
 
cag gac atc cct acc ttc ccc tta atc tct gcc ttc atc cgc aca ctc   1490
Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu
480                 485                 490                 495
 
cgt tac cac act ggg tca ttg gca ttt gga gcc ctc atc ctg acc ctt   1538
Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu
                500                 505                 510
 
gtg cag ata gcc cgg gtc atc ttg gag tat att gac cac aag ctc aga   1586
Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg
            515                 520                 525
 
gga gtg cag aac cct gta gcc cgc tgc atc atg tgc tgt ttc aag tgc   1634
Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys
        530                 535                 540
 
tgc ctc tgg tgt ctg gaa aaa ttt atc aag ttc cta aac cgc aat gca   1682
Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala
    545                 550                 555
 
tac atc atg atc gcc atc tac ggg aag aat ttc tgt gtc tca gcc aaa   1730
Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys
560                 565                 570                 575
 
aat gcg ttc atg cta ctc atg cga aac att gtc agg gtg gtc gtc ctg   1778
Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu
                580                 585                 590
 
gac aaa gtc aca gac ctg ctg ctg ttc ttt ggg aag ctg ctg gtg gtc   1826
Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val
            595                 600                 605
 
gga ggc gtg ggg gtc ctg tcc ttc ttt ttt ttc tcc ggt cgc atc ccg   1874
Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro
        610                 615                 620
 
ggg ctg ggt aaa gac ttt aag agc ccc cac ctc aac tat tac tgg ctg   1922
Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu
    625                 630                 635
 
ccc atc atg acc tcc atc ctg ggg gcc tat gtc atc gcc agc ggc ttc   1970
Pro Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe
640                 645                 650                 655
 
ttc agc gtt ttc ggc atg tgt gtg gac acg ctc ttc ctc tgc ttc ctg   2018
Phe Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu
                660                 665                 670
 
gaa gac ctg gag cgg aac aac ggc tcc ctg gac cgg ccc tac tac atg   2066
Glu Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met
            675                 680                 685
 
tcc aag agc ctt cta aag att ctg ggc aag aag aac gag gcg ccc ccg   2114
Ser Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro
        690                 695                 700
 
gac aac aag aag agg aag aag tga cagctccggc cctgatccag gactgcaccc  2168
Asp Asn Lys Lys Arg Lys Lys  *
    705                 710
 
cacccccacc gtccagccat ccaacctcac ttcgccttac aggtctccat tttgtggtaa 2228
aaaaaggttt taggccaggc gccgtggctc acgcctgtaa tccaacactt tgagaggctg 2288
aggcgggcgg atcacctgag tcaggagttc gagaccagcc tggccaacat ggtgaaacct 2348
ccgtctctat taaaaataca aaaattagcc gagagtggtg gcatgcacct gtcatcccag 2408
ctactcggga ggctgaggca ggagaatcgc ttgaacccgg gaggcagagg ttgcagtgag 2468
ccgagatcgc gccactgcac tccaacctgg gtgacagact ctgtctccaa aacaaaacaa 2528
acaaacaaaa agattttatt aaagatattt tgttaactca gtaaaaaaaa aaaaaaaaa  2587

<210> 8
<211> 710
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(710)
<223> 24P4C12 variant 4 coding sequence

<400> 8
Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro
 1               5                  10                  15      
Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys
            20                  25                  30          
Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr
        35                  40                  45              
Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val
    50                  55                  60                  
Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn
65                  70                  75                  80  
Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
                85                  90                  95      
Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
            100                 105                 110         
Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
        115                 120                 125             
Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn
    130                 135                 140                 
Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
145                 150                 155                 160 
Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
                165                 170                 175     
Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala Leu
            180                 185                 190         
Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
        195                 200                 205             
Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
    210                 215                 220                 
Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu
225                 230                 235                 240 
Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro
                245                 250                 255     
Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly
            260                 265                 270         
Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala
        275                 280                 285             
Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser
    290                 295                 300                 
Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu
305                 310                 315                 320 
Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile
                325                 330                 335     
Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met
            340                 345                 350         
Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys
        355                 360                 365             
Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly Gln
    370                 375                 380                 
Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys Glu
385                 390                 395                 400 
Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val Asn
                405                 410                 415     
Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser Lys
            420                 425                 430         
Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val Leu
        435                 440                 445             
Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys Val
    450                 455                 460                 
Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro Gln
465                 470                 475                 480 
Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu Arg
                485                 490                 495     
Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu Val
            500                 505                 510         
Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg Gly
        515                 520                 525             
Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys Cys
    530                 535                 540                 
Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr
545                 550                 555                 560 
Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys Asn
                565                 570                 575     
Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu Asp
            580                 585                 590         
Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val Gly
        595                 600                 605             
Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro Gly
    610                 615                 620                 
Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu Pro
625                 630                 635                 640 
Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe
                645                 650                 655     
Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu
            660                 665                 670         
Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser
        675                 680                 685             
Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp
    690                 695                 700                 
Asn Lys Lys Arg Lys Lys
705                 710 


<210> 9
<211> 2587
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(2587)
<223> 24P4C12 variant 5

<220> 
<221> CDS            
<222> (6)...(2138)

<400> 9
gagcc atg ggg gga aag cag cgg gac gag gat gac gag gcc tac ggg aag 50
      Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys
       1               5                   10                  15
 
cca gtc aaa tac gac ccc tcc ttt cga ggc ccc atc aag aac aga agc   98
Pro Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser
                 20                  25                  30
 
tgc aca gat gtc atc tgc tgc gtc ctc ttc ctg ctc ttc att cta ggt   146
Cys Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly
             35                  40                  45
 
tac atc gtg gtg ggg att gtg gcc tgg ttg tat gga gac ccc cgg caa   194
Tyr Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln
         50                  55                  60
 
gtc ctc tac ccc agg aac tct act ggg gcc tac tgt ggc atg ggg gag   242
Val Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu
     65                  70                  75
 
aac aaa gat aag ccg tat ctc ctg tac ttc aac atc ttc agc tgc atc   290
Asn Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile
 80                  85                  90                  95
 
ctg tcc agc aac atc atc tca gtt gct gag aac ggc cta cag tgc ccc   338
Leu Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro
                100                 105                 110
 
aca ccc cag gtg tgt gtg tcc tcc tgc ccg gag gac cca tgg act gtg   386
Thr Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val
            115                 120                 125
 
gga aaa aac gag ttc tca cag act gtt ggg gaa gtc ttc tat aca aaa   434
Gly Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys
        130                 135                 140
 
aac agg aac ttt tgt ctg cca ggg gta ccc tgg aat atg acg gtg atc   482
Asn Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile
    145                 150                 155
 
aca agc ctg caa cag gaa ctc tgc ccc agt ttc ctc ctc ccc tct gct   530
Thr Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala
160                 165                 170                 175
 
cca gct ctg ggg cgc tgc ttt cca tgg acc aac gtt act cca ccg gcg   578
Pro Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala
                180                 185                 190
 
ctc cca ggg atc acc aat gac acc acc ata cag cag ggg atc agc ggt   626
Leu Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly
            195                 200                 205
 
ctt att gac agc ctc aat gcc cga gac atc agt gtt aag atc ttt gaa   674
Leu Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu
        210                 215                 220
 
gat ttt gcc cag tcc tgg tat tgg att ctt gtt gcc ctg ggg gtg gct   722
Asp Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala
    225                 230                 235
 
ctg gtc ttg agc cta ctg ttt atc ttg ctt ctg cgc ctg gtg gct ggg   770
Leu Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly
240                 245                 250                 255
 
ccc ctg gtg ctg gtg ctg atc ctg gga gtg ctg ggc gtg ctg gca tac   818
Pro Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr
                260                 265                 270
 
ggc atc tac tac tgc tgg gag gag tac cga gtg ctg cgg gac aag ggc   866
Gly Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly
            275                 280                 285
 
gcc tcc atc tcc cag ctg ggt ttc acc acc aac ctc agt gcc tac cag   914
Ala Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln
        290                 295                 300
 
agc gtg cag gag acc tgg ctg gcc gcc ctg atc gtg ttg gcg gtg ctt   962
Ser Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu
    305                 310                 315
 
gaa gcc atc ctg ctg ctg gtg ctc atc ttc ctg cgg cag cgg att cgt   1010
Glu Ala Ile Leu Leu Leu Val Leu Ile Phe Leu Arg Gln Arg Ile Arg
320                 325                 330                 335
 
att gcc atc gcc ctc ctg aag gag gcc agc aag gct gtg gga cag atg   1058
Ile Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met
                340                 345                 350
 
atg tct acc atg ttc tac cca ctg gtc acc ttt gtc ctc ctc ctc atc   1106
Met Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile
            355                 360                 365
 
tgc att gcc tac tgg gcc atg act gct ctg tac ctg gct aca tcg ggg   1154
Cys Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly
        370                 375                 380
 
caa ccc cag tat gtg ctc tgg gca tcc aac atc agc tcc ccc ggc tgt   1202
Gln Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys
    385                 390                 395
 
gag aaa gtg cca ata aat aca tca tgc aac ccc acg gcc cac ctt gtg   1250
Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val
400                 405                 410                 415
 
aac tcc tcg tgc cca ggg ctg atg tgc gtc ttc cag ggc tac tca tcc   1298
Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser
                420                 425                 430
 
aaa ggc cta atc caa cgt tct gtc ttc aat ctg caa atc tat ggg gtc   1346
Lys Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val
            435                 440                 445
 
ctg ggg ctc ttc tgg acc ctt aac tgg gta ctg gcc ctg ggc caa tgc   1394
Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys
        450                 455                 460
 
gtc ctc gct gga gcc ttt gcc tcc ttc tac tgg gcc ttc cac aag ccc   1442
Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro
    465                 470                 475
 
cag gac atc cct acc ttc ccc tta atc tct gcc ttc atc cgc aca ctc   1490
Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu
480                 485                 490                 495
 
cgt tac cac act ggg tca ttg gca ttt gga gcc ctc atc ctg acc ctt   1538
Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu
                500                 505                 510
 
gtg cag ata gcc cgg gtc atc ttg gag tat att gac cac aag ctc aga   1586
Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg
            515                 520                 525
 
gga gtg cag aac cct gta gcc cgc tgc atc atg tgc tgt ttc aag tgc   1634
Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys
        530                 535                 540
 
tgc ctc tgg tgt ctg gaa aaa ttt atc aag ttc cta aac cgc aat gca   1682
Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala
    545                 550                 555
 
tac atc atg atc gcc atc tac ggg aag aat ttc tgt gtc tca gcc aaa   1730
Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys
560                 565                 570                 575
 
aat gcg ttc atg cta ctc atg cga aac att gtc agg gtg gtc gtc ctg   1778
Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu
                580                 585                 590
 
gac aaa gtc aca gac ctg ctg ctg ttc ttt ggg aag ctg ctg gtg gtc   1826
Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val
            595                 600                 605
 
gga ggc gtg ggg gtc ctg tcc ttc ttt ttt ttc tcc ggt cgc atc ccg   1874
Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro
        610                 615                 620
 
ggg ctg ggt aaa gac ttt aag agc ccc cac ctc aac tat tac tgg ctg   1922
Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu
    625                 630                 635
 
ccc atc atg acc tcc atc ctg ggg gcc tat gtc atc gcc agc ggc ttc   1970
Pro Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe
640                 645                 650                 655
 
ttc agc gtt ttc ggc atg tgt gtg gac acg ctc ttc ctc tgc ttc ctg   2018
Phe Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu
                660                 665                 670
 
gaa gac ctg gag cgg aac aac ggc tcc ctg gac cgg ccc tac tac atg   2066
Glu Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met
            675                 680                 685
 
tcc aag agc ctt cta aag att ctg ggc aag aag aac gag gcg ccc ccg   2114
Ser Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro
        690                 695                 700
 
gac aac aag aag agg aag aag tga cagctccggc cctgatccag gactgcaccc  2168
Asp Asn Lys Lys Arg Lys Lys  *
    705                 710
 
cacccccacc gtccagccat ccaacctcac ttcgccttac aggtctccat tttgtggtaa 2228
aaaaaggttt taggccaggc gccgtggctc acgcctgtaa tccaacactt tgagaggctg 2288
aggcgggcgg atcacctgag tcaggagttc gagaccagcc tggccaacat ggtgaaacct 2348
ccgtctctat taaaaataca aaaattagcc gagagtggtg gcatgcacct gtcatcccag 2408
ctactcggga ggctgaggca ggagaatcgc ttgaacccgg gaggcagagg ttgcagtgag 2468
ccgagatcgc gccactgcac tccaacctgg gtgacagact ctgtctccaa aacaaaacaa 2528
acaaacaaaa agattttatt aaagatattt tgttaactca gtaaaaaaaa aaaaaaaaa  2587

<210> 10
<211> 710
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(710)
<223> 24P4C12 variant 5 coding sequence

<400> 10
Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro
 1               5                  10                  15      
Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys
            20                  25                  30          
Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr
        35                  40                  45              
Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val
    50                  55                  60                  
Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn
65                  70                  75                  80  
Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
                85                  90                  95      
Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
            100                 105                 110         
Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
        115                 120                 125             
Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn
    130                 135                 140                 
Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
145                 150                 155                 160 
Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
                165                 170                 175     
Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala Leu
            180                 185                 190         
Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
        195                 200                 205             
Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
    210                 215                 220                 
Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu
225                 230                 235                 240 
Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro
                245                 250                 255     
Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly
            260                 265                 270         
Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala
        275                 280                 285             
Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser
    290                 295                 300                 
Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu
305                 310                 315                 320 
Ala Ile Leu Leu Leu Val Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile
                325                 330                 335     
Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met
            340                 345                 350         
Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys
        355                 360                 365             
Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly Gln
    370                 375                 380                 
Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys Glu
385                 390                 395                 400 
Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val Asn
                405                 410                 415     
Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser Lys
            420                 425                 430         
Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val Leu
        435                 440                 445             
Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys Val
    450                 455                 460                 
Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro Gln
465                 470                 475                 480 
Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu Arg
                485                 490                 495     
Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu Val
            500                 505                 510         
Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg Gly
        515                 520                 525             
Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys Cys
    530                 535                 540                 
Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr
545                 550                 555                 560 
Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys Asn
                565                 570                 575     
Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu Asp
            580                 585                 590         
Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val Gly
        595                 600                 605             
Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro Gly
    610                 615                 620                 
Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu Pro
625                 630                 635                 640 
Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe
                645                 650                 655     
Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu
            660                 665                 670         
Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser
        675                 680                 685             
Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp
    690                 695                 700                 
Asn Lys Lys Arg Lys Lys
705                 710 


<210> 11
<211> 2587
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(2587)
<223> 24P4C12 variant 6

<220> 
<221> CDS            
<222> (6)...(2138)

<400> 11
gagcc atg ggg gga aag cag cgg gac gag gat gac gag gcc tac ggg aag 50
      Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys
       1               5                   10                  15
 
cca gtc aaa tac gac ccc tcc ttt cga ggc ccc atc aag aac aga agc   98
Pro Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser
                 20                  25                  30
 
tgc aca gat gtc atc tgc tgc gtc ctc ttc ctg ctc ttc att cta ggt   146
Cys Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly
             35                  40                  45
 
tac atc gtg gtg ggg att gtg gcc tgg ttg tat gga gac ccc cgg caa   194
Tyr Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln
         50                  55                  60
 
gtc ctc tac ccc agg aac tct act ggg gcc tac tgt ggc atg ggg gag   242
Val Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu
     65                  70                  75
 
aac aaa gat aag ccg tat ctc ctg tac ttc aac atc ttc agc tgc atc   290
Asn Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile
 80                  85                  90                  95
 
ctg tcc agc aac atc atc tca gtt gct gag aac ggc cta cag tgc ccc   338
Leu Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro
                100                 105                 110
 
aca ccc cag gtg tgt gtg tcc tcc tgc ccg gag gac cca tgg act gtg   386
Thr Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val
            115                 120                 125
 
gga aaa aac gag ttc tca cag act gtt ggg gaa gtc ttc tat aca aaa   434
Gly Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys
        130                 135                 140
 
aac agg aac ttt tgt ctg cca ggg gta ccc tgg aat atg acg gtg atc   482
Asn Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile
    145                 150                 155
 
aca agc ctg caa cag gaa ctc tgc ccc agt ttc ctc ctc ccc tct gct   530
Thr Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala
160                 165                 170                 175
 
cca gct ctg ggg cgc tgc ttt cca tgg acc aac gtt act cca ccg gcg   578
Pro Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala
                180                 185                 190
 
ctc cca ggg atc acc aat gac acc acc ata cag cag ggg atc agc ggt   626
Leu Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly
            195                 200                 205
 
ctt att gac agc ctc aat gcc cga gac atc agt gtt aag atc ttt gaa   674
Leu Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu
        210                 215                 220
 
gat ttt gcc cag tcc tgg tat tgg att ctt gtt gcc ctg ggg gtg gct   722
Asp Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala
    225                 230                 235
 
ctg gtc ttg agc cta ctg ttt atc ttg ctt ctg cgc ctg gtg gct ggg   770
Leu Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly
240                 245                 250                 255
 
ccc ctg gtg ctg gtg ctg atc ctg gga gtg ctg ggc gtg ctg gca tac   818
Pro Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr
                260                 265                 270
 
ggc atc tac tac tgc tgg gag gag tac cga gtg ctg cgg gac aag ggc   866
Gly Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly
            275                 280                 285
 
gcc tcc atc tcc cag ctg ggt ttc acc acc aac ctc agt gcc tac cag   914
Ala Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln
        290                 295                 300
 
agc gtg cag gag acc tgg ctg gcc gcc ctg atc gtg ttg gcg gtg ctt   962
Ser Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu
    305                 310                 315
 
gaa gcc atc ctg ctg ctg atg ctc atc ttc ctg cgg cag cgg att cgt   1010
Glu Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg
320                 325                 330                 335
 
att gcc atc gcc ctc ctg aag gag gcc agc aag gct gtg gga cag atg   1058
Ile Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met
                340                 345                 350
 
atg tct acc atg ttc tac cca ctg gtc acc ttt gtc ctc ctc ctc atc   1106
Met Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile
            355                 360                 365
 
tgc att gcc tac tgg gcc atg act gct ctg tac ctg gct aca tcg ggg   1154
Cys Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly
        370                 375                 380
 
caa ccc cag tat gtg ctc tgg gca tcc aac atc agc tcc ccc ggc tgt   1202
Gln Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys
    385                 390                 395
 
gag aaa gtg cca ata aat aca tca tgc aac ccc acg gcc cac ctt gtg   1250
Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val
400                 405                 410                 415
 
aac tcc tcg tgc cca ggg ctg atg tgc gtc ttc cag ggc tac tca tcc   1298
Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser
                420                 425                 430
 
aaa ggc cta atc cca cgt tct gtc ttc aat ctg caa atc tat ggg gtc   1346
Lys Gly Leu Ile Pro Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val
            435                 440                 445
 
ctg ggg ctc ttc tgg acc ctt aac tgg gta ctg gcc ctg ggc caa tgc   1394
Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys
        450                 455                 460
 
gtc ctc gct gga gcc ttt gcc tcc ttc tac tgg gcc ttc cac aag ccc   1442
Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro
    465                 470                 475
 
cag gac atc cct acc ttc ccc tta atc tct gcc ttc atc cgc aca ctc   1490
Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu
480                 485                 490                 495
 
cgt tac cac act ggg tca ttg gca ttt gga gcc ctc atc ctg acc ctt   1538
Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu
                500                 505                 510
 
gtg cag ata gcc cgg gtc atc ttg gag tat att gac cac aag ctc aga   1586
Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg
            515                 520                 525
 
gga gtg cag aac cct gta gcc cgc tgc atc atg tgc tgt ttc aag tgc   1634
Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys
        530                 535                 540
 
tgc ctc tgg tgt ctg gaa aaa ttt atc aag ttc cta aac cgc aat gca   1682
Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala
    545                 550                 555
 
tac atc atg atc gcc atc tac ggg aag aat ttc tgt gtc tca gcc aaa   1730
Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys
560                 565                 570                 575
 
aat gcg ttc atg cta ctc atg cga aac att gtc agg gtg gtc gtc ctg   1778
Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu
                580                 585                 590
 
gac aaa gtc aca gac ctg ctg ctg ttc ttt ggg aag ctg ctg gtg gtc   1826
Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val
            595                 600                 605
 
gga ggc gtg ggg gtc ctg tcc ttc ttt ttt ttc tcc ggt cgc atc ccg   1874
Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro
        610                 615                 620
 
ggg ctg ggt aaa gac ttt aag agc ccc cac ctc aac tat tac tgg ctg   1922
Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu
    625                 630                 635
 
ccc atc atg acc tcc atc ctg ggg gcc tat gtc atc gcc agc ggc ttc   1970
Pro Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe
640                 645                 650                 655
 
ttc agc gtt ttc ggc atg tgt gtg gac acg ctc ttc ctc tgc ttc ctg   2018
Phe Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu
                660                 665                 670
 
gaa gac ctg gag cgg aac aac ggc tcc ctg gac cgg ccc tac tac atg   2066
Glu Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met
            675                 680                 685
 
tcc aag agc ctt cta aag att ctg ggc aag aag aac gag gcg ccc ccg   2114
Ser Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro
        690                 695                 700
 
gac aac aag aag agg aag aag tga cagctccggc cctgatccag gactgcaccc  2168
Asp Asn Lys Lys Arg Lys Lys  *
    705                 710
 
cacccccacc gtccagccat ccaacctcac ttcgccttac aggtctccat tttgtggtaa 2228
aaaaaggttt taggccaggc gccgtggctc acgcctgtaa tccaacactt tgagaggctg 2288
aggcgggcgg atcacctgag tcaggagttc gagaccagcc tggccaacat ggtgaaacct 2348
ccgtctctat taaaaataca aaaattagcc gagagtggtg gcatgcacct gtcatcccag 2408
ctactcggga ggctgaggca ggagaatcgc ttgaacccgg gaggcagagg ttgcagtgag 2468
ccgagatcgc gccactgcac tccaacctgg gtgacagact ctgtctccaa aacaaaacaa 2528
acaaacaaaa agattttatt aaagatattt tgttaactca gtaaaaaaaa aaaaaaaaa  2587

<210> 12
<211> 710
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(710)
<223> 24P4C12 variant 6 coding sequence

<400> 12
Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro
 1               5                  10                  15      
Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys
            20                  25                  30          
Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr
        35                  40                  45              
Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val
    50                  55                  60                  
Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn
65                  70                  75                  80  
Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
                85                  90                  95      
Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
            100                 105                 110         
Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
        115                 120                 125             
Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn
    130                 135                 140                 
Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
145                 150                 155                 160 
Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
                165                 170                 175     
Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala Leu
            180                 185                 190         
Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
        195                 200                 205             
Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
    210                 215                 220                 
Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu
225                 230                 235                 240 
Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro
                245                 250                 255     
Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly
            260                 265                 270         
Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala
        275                 280                 285             
Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser
    290                 295                 300                 
Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu
305                 310                 315                 320 
Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile
                325                 330                 335     
Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met
            340                 345                 350         
Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys
        355                 360                 365             
Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly Gln
    370                 375                 380                 
Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys Glu
385                 390                 395                 400 
Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val Asn
                405                 410                 415     
Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser Lys
            420                 425                 430         
Gly Leu Ile Pro Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val Leu
        435                 440                 445             
Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys Val
    450                 455                 460                 
Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro Gln
465                 470                 475                 480 
Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu Arg
                485                 490                 495     
Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu Val
            500                 505                 510         
Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg Gly
        515                 520                 525             
Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys Cys
    530                 535                 540                 
Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr
545                 550                 555                 560 
Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys Asn
                565                 570                 575     
Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu Asp
            580                 585                 590         
Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val Gly
        595                 600                 605             
Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro Gly
    610                 615                 620                 
Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu Pro
625                 630                 635                 640 
Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe
                645                 650                 655     
Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu
            660                 665                 670         
Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser
        675                 680                 685             
Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp
    690                 695                 700                 
Asn Lys Lys Arg Lys Lys
705                 710 


<210> 13
<211> 2251
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(2251)
<223> 24P4C12 variant 7

<220> 
<221> CDS            
<222> (6)...(1802)

<400> 13
gagcc atg ggg gga aag cag cgg gac gag gat gac gag gcc tac ggg aag 50
      Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys
       1               5                   10                  15
 
cca gtc aaa tac gac ccc tcc ttt cga ggc ccc atc aag aac aga agc   98
Pro Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser
                 20                  25                  30
 
tgc aca gat gtc atc tgc tgc gtc ctc ttc ctg ctc ttc att cta ggt   146
Cys Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly
             35                  40                  45
 
tac atc gtg gtg ggg att gtg gcc tgg ttg tat gga gac ccc cgg caa   194
Tyr Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln
         50                  55                  60
 
gtc ctc tac ccc agg aac tct act ggg gcc tac tgt ggc atg ggg gag   242
Val Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu
     65                  70                  75
 
aac aaa gat aag ccg tat ctc ctg tac ttc aac atc ttc agc tgc atc   290
Asn Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile
 80                  85                  90                  95
 
ctg tcc agc aac atc atc tca gtt gct gag aac ggc cta cag tgc ccc   338
Leu Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro
                100                 105                 110
 
aca ccc cag gtg tgt gtg tcc tcc tgc ccg gag gac cca tgg act gtg   386
Thr Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val
            115                 120                 125
 
gga aaa aac gag ttc tca cag act gtt ggg gaa gtc ttc tat aca aaa   434
Gly Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys
        130                 135                 140
 
aac agg aac ttt tgt ctg cca ggg gta ccc tgg aat atg acg gtg atc   482
Asn Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile
    145                 150                 155
 
aca agc ctg caa cag gaa ctc tgc ccc agt ttc ctc ctc ccc tct gct   530
Thr Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala
160                 165                 170                 175
 
cca gct ctg ggg cgc tgc ttt cca tgg acc aac gtt act cca ccg gcg   578
Pro Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala
                180                 185                 190
 
ctc cca ggg atc acc aat gac acc acc ata cag cag ggg atc agc ggt   626
Leu Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly
            195                 200                 205
 
ctt att gac agc ctc aat gcc cga gac atc agt gtt aag atc ttt gaa   674
Leu Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu
        210                 215                 220
 
gat ttt gcc cag tcc tgg tat tgg att ctt gtg gct gtg gga cag atg   722
Asp Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Val Gly Gln Met
    225                 230                 235
 
atg tct acc atg ttc tac cca ctg gtc acc ttt gtc ctc ctc ctc atc   770
Met Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile
240                 245                 250                 255
 
tgc att gcc tac tgg gcc atg act gct ctg tac ctg gct aca tcg ggg   818
Cys Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly
                260                 265                 270
 
caa ccc cag tat gtg ctc tgg gca tcc aac atc agc tcc ccc ggc tgt   866
Gln Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys
            275                 280                 285
 
gag aaa gtg cca ata aat aca tca tgc aac ccc acg gcc cac ctt gtg   914
Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val
        290                 295                 300
 
aac tcc tcg tgc cca ggg ctg atg tgc gtc ttc cag ggc tac tca tcc   962
Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser
    305                 310                 315
 
aaa ggc cta atc caa cgt tct gtc ttc aat ctg caa atc tat ggg gtc   1010
Lys Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val
320                 325                 330                 335
 
ctg ggg ctc ttc tgg acc ctt aac tgg gta ctg gcc ctg ggc caa tgc   1058
Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys
                340                 345                 350
 
gtc ctc gct gga gcc ttt gcc tcc ttc tac tgg gcc ttc cac aag ccc   1106
Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro
            355                 360                 365
 
cag gac atc cct acc ttc ccc tta atc tct gcc ttc atc cgc aca ctc   1154
Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu
        370                 375                 380
 
cgt tac cac act ggg tca ttg gca ttt gga gcc ctc atc ctg acc ctt   1202
Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu
    385                 390                 395
 
gtg cag ata gcc cgg gtc atc ttg gag tat att gac cac aag ctc aga   1250
Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg
400                 405                 410                 415
 
gga gtg cag aac cct gta gcc cgc tgc atc atg tgc tgt ttc aag tgc   1298
Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys
                420                 425                 430
 
tgc ctc tgg tgt ctg gaa aaa ttt atc aag ttc cta aac cgc aat gca   1346
Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala
            435                 440                 445
 
tac atc atg atc gcc atc tac ggg aag aat ttc tgt gtc tca gcc aaa   1394
Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys
        450                 455                 460
 
aat gcg ttc atg cta ctc atg cga aac att gtc agg gtg gtc gtc ctg   1442
Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu
    465                 470                 475
 
gac aaa gtc aca gac ctg ctg ctg ttc ttt ggg aag ctg ctg gtg gtc   1490
Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val
480                 485                 490                 495
 
gga ggc gtg ggg gtc ctg tcc ttc ttt ttt ttc tcc ggt cgc atc ccg   1538
Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro
                500                 505                 510
 
ggg ctg ggt aaa gac ttt aag agc ccc cac ctc aac tat tac tgg ctg   1586
Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu
            515                 520                 525
 
ccc atc atg acc tcc atc ctg ggg gcc tat gtc atc gcc agc ggc ttc   1634
Pro Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe
        530                 535                 540
 
ttc agc gtt ttc ggc atg tgt gtg gac acg ctc ttc ctc tgc ttc ctg   1682
Phe Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu
    545                 550                 555
 
gaa gac ctg gag cgg aac aac ggc tcc ctg gac cgg ccc tac tac atg   1730
Glu Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met
560                 565                 570                 575
 
tcc aag agc ctt cta aag att ctg ggc aag aag aac gag gcg ccc ccg   1778
Ser Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro
                580                 585                 590
 
gac aac aag aag agg aag aag tga cagctccggc cctgatccag gactgcaccc  1832
Asp Asn Lys Lys Arg Lys Lys  *
            595
 
cacccccacc gtccagccat ccaacctcac ttcgccttac aggtctccat tttgtggtaa 1892
aaaaaggttt taggccaggc gccgtggctc acgcctgtaa tccaacactt tgagaggctg 1952
aggcgggcgg atcacctgag tcaggagttc gagaccagcc tggccaacat ggtgaaacct 2012
ccgtctctat taaaaataca aaaattagcc gagagtggtg gcatgcacct gtcatcccag 2072
ctactcggga ggctgaggca ggagaatcgc ttgaacccgg gaggcagagg ttgcagtgag 2132
ccgagatcgc gccactgcac tccaacctgg gtgacagact ctgtctccaa aacaaaacaa 2192
acaaacaaaa agattttatt aaagatattt tgttaactca gtaaaaaaaa aaaaaaaaa  2251

<210> 14
<211> 598
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(598)
<223> 24P4C12 variant 7 coding sequence

<400> 14
Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro
 1               5                  10                  15      
Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys
            20                  25                  30          
Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr
        35                  40                  45              
Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val
    50                  55                  60                  
Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn
65                  70                  75                  80  
Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
                85                  90                  95      
Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
            100                 105                 110         
Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
        115                 120                 125             
Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn
    130                 135                 140                 
Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
145                 150                 155                 160 
Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
                165                 170                 175     
Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala Leu
            180                 185                 190         
Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
        195                 200                 205             
Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
    210                 215                 220                 
Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Val Gly Gln Met Met
225                 230                 235                 240 
Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys
                245                 250                 255     
Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly Gln
            260                 265                 270         
Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys Glu
        275                 280                 285             
Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val Asn
    290                 295                 300                 
Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser Lys
305                 310                 315                 320 
Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val Leu
                325                 330                 335     
Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys Val
            340                 345                 350         
Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro Gln
        355                 360                 365             
Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu Arg
    370                 375                 380                 
Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu Val
385                 390                 395                 400 
Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg Gly
                405                 410                 415     
Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys Cys
            420                 425                 430         
Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr
        435                 440                 445             
Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys Asn
    450                 455                 460                 
Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu Asp
465                 470                 475                 480 
Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val Gly
                485                 490                 495     
Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro Gly
            500                 505                 510         
Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu Pro
        515                 520                 525             
Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe
    530                 535                 540                 
Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu
545                 550                 555                 560 
Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser
                565                 570                 575     
Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp
            580                 585                 590         
Asn Lys Lys Arg Lys Lys
        595             


<210> 15
<211> 2623
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(2623)
<223> 24P4C12 variant 8

<220> 
<221> CDS            
<222> (6)...(2174)

<400> 15
gagcc atg ggg gga aag cag cgg gac gag gat gac gag gcc tac ggg aag 50
      Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys
       1               5                   10                  15
 
cca gtc aaa tac gac ccc tcc ttt cga ggc ccc atc aag aac aga agc   98
Pro Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser
                 20                  25                  30
 
tgc aca gat gtc atc tgc tgc gtc ctc ttc ctg ctc ttc att cta ggt   146
Cys Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly
             35                  40                  45
 
tac atc gtg gtg ggg att gtg gcc tgg ttg tat gga gac ccc cgg caa   194
Tyr Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln
         50                  55                  60
 
gtc ctc tac ccc agg aac tct act ggg gcc tac tgt ggc atg ggg gag   242
Val Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu
     65                  70                  75
 
aac aaa gat aag ccg tat ctc ctg tac ttc aac atc ttc agc tgc atc   290
Asn Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile
 80                  85                  90                  95
 
ctg tcc agc aac atc atc tca gtt gct gag aac ggc cta cag tgc ccc   338
Leu Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro
                100                 105                 110
 
aca ccc cag gtg tgt gtg tcc tcc tgc ccg gag gac cca tgg act gtg   386
Thr Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val
            115                 120                 125
 
gga aaa aac gag ttc tca cag act gtt ggg gaa gtc ttc tat aca aaa   434
Gly Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys
        130                 135                 140
 
aac agg aac ttt tgt ctg cca ggg gta ccc tgg aat atg acg gtg atc   482
Asn Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile
    145                 150                 155
 
aca agc ctg caa cag gaa ctc tgc ccc agt ttc ctc ctc ccc tct gct   530
Thr Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala
160                 165                 170                 175
 
cca gct ctg ggg cgc tgc ttt cca tgg acc aac gtt act cca ccg gcg   578
Pro Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala
                180                 185                 190
 
ctc cca ggg atc acc aat gac acc acc ata cag cag ggg atc agc ggt   626
Leu Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly
            195                 200                 205
 
ctt att gac agc ctc aat gcc cga gac atc agt gtt aag atc ttt gaa   674
Leu Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu
        210                 215                 220
 
gat ttt gcc cag tcc tgg tat tgg att ctt gtt gcc ctg ggg gtg gct   722
Asp Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala
    225                 230                 235
 
ctg gtc ttg agc cta ctg ttt atc ttg ctt ctg cgc ctg gtg gct ggg   770
Leu Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly
240                 245                 250                 255
 
ccc ctg gtg ctg gtg ctg atc ctg gga gtg ctg ggc gtg ctg gca tac   818
Pro Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr
                260                 265                 270
 
ggc atc tac tac tgc tgg gag gag tac cga gtg ctg cgg gac aag ggc   866
Gly Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly
            275                 280                 285
 
gcc tcc atc tcc cag ctg ggt ttc acc acc aac ctc agt gcc tac cag   914
Ala Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln
        290                 295                 300
 
agc gtg cag gag acc tgg ctg gcc gcc ctg atc gtg ttg gcg gtg ctt   962
Ser Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu
    305                 310                 315
 
gaa gcc atc ctg ctg ctg atg ctc atc ttc ctg cgg cag cgg att cgt   1010
Glu Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg
320                 325                 330                 335
 
att gcc atc gcc ctc ctg aag gag gcc agc aag gct gtg gga cag atg   1058
Ile Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met
                340                 345                 350
 
atg tct acc atg ttc tac cca ctg gtc acc ttt gtc ctc ctc ctc atc   1106
Met Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile
            355                 360                 365
 
tgc att gcc tac tgg gcc atg act gct ctg tac ctg gct aca tcg ggg   1154
Cys Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly
        370                 375                 380
 
caa ccc cag tat gtg ctc tgg gca tcc aac atc agc tcc ccc ggc tgt   1202
Gln Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys
    385                 390                 395
 
gag aaa gtg cca ata aat aca tca tgc aac ccc acg gcc cac ctt gtg   1250
Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val
400                 405                 410                 415
 
aac tcc tcg tgc cca ggg ctg atg tgc gtc ttc cag ggc tac tca tcc   1298
Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser
                420                 425                 430
 
aaa ggc cta atc caa cgt tct gtc ttc aat ctg caa atc tat ggg gtc   1346
Lys Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val
            435                 440                 445
 
ctg ggg ctc ttc tgg acc ctt aac tgg gta ctg gcc ctg ggc caa tgc   1394
Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys
        450                 455                 460
 
gtc ctc gct gga gcc ttt gcc tcc ttc tac tgg gcc ttc cac aag ccc   1442
Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro
    465                 470                 475
 
cag gac atc cct acc ttc ccc tta atc tct gcc ttc atc cgc aca ctc   1490
Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu
480                 485                 490                 495
 
cgt tac cac act ggg tca ttg gca ttt gga gcc ctc atc ctg acc ctt   1538
Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu
                500                 505                 510
 
gtg cag ata gcc cgg gtc atc ttg gag tat att gac cac aag ctc aga   1586
Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg
            515                 520                 525
 
gga gtg cag aac cct gta gcc cgc tgc atc atg tgc tgt ttc aag tgc   1634
Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys
        530                 535                 540
 
tgc ctc tgg tgt ctg gaa aaa ttt atc aag ttc cta aac cgc aat gca   1682
Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala
    545                 550                 555
 
tac atc atg atc gcc atc tac ggg aag aat ttc tgt gtc tca gcc aaa   1730
Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys
560                 565                 570                 575
 
aat gcg ttc atg cta ctc atg cga aac att gtc agg gtg gtc gtc ctg   1778
Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu
                580                 585                 590
 
gac aaa gtc aca gac ctg ctg ctg ttc ttt ggg aag ctg ctg gtg gtc   1826
Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val
            595                 600                 605
 
gga ggc gtg ggg gtc ctg tcc ttc ttt ttt ttc tcc ggt cgc atc ccg   1874
Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro
        610                 615                 620
 
ggg ctg ggt aaa gac ttt aag agc ccc cac ctc aac tat tac tgg ctg   1922
Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu
    625                 630                 635
 
ccc atc atg agg aac cca ata acc cca acg ggt cat gtc ttc cag acc   1970
Pro Ile Met Arg Asn Pro Ile Thr Pro Thr Gly His Val Phe Gln Thr
640                 645                 650                 655
 
tcc atc ctg ggg gcc tat gtc atc gcc agc ggc ttc ttc agc gtt ttc   2018
Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe Ser Val Phe
                660                 665                 670
 
ggc atg tgt gtg gac acg ctc ttc ctc tgc ttc ctg gaa gac ctg gag   2066
Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu Asp Leu Glu
            675                 680                 685
 
cgg aac aac ggc tcc ctg gac cgg ccc tac tac atg tcc aag agc ctt   2114
Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser Lys Ser Leu
        690                 695                 700
 
cta aag att ctg ggc aag aag aac gag gcg ccc ccg gac aac aag aag   2162
Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp Asn Lys Lys
    705                 710                 715
 
agg aag aag tga cagctccggc cctgatccag gactgcaccc cacccccacc       2214
Arg Lys Lys  *
720
 
gtccagccat ccaacctcac ttcgccttac aggtctccat tttgtggtaa aaaaaggttt 2274
taggccaggc gccgtggctc acgcctgtaa tccaacactt tgagaggctg aggcgggcgg 2334
atcacctgag tcaggagttc gagaccagcc tggccaacat ggtgaaacct ccgtctctat 2394
taaaaataca aaaattagcc gagagtggtg gcatgcacct gtcatcccag ctactcggga 2454
ggctgaggca ggagaatcgc ttgaacccgg gaggcagagg ttgcagtgag ccgagatcgc 2514
gccactgcac tccaacctgg gtgacagact ctgtctccaa aacaaaacaa acaaacaaaa 2574
agattttatt aaagatattt tgttaactca gtaaaaaaaa aaaaaaaaa             2623

<210> 16
<211> 722
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(722)
<223> 24P4C12 variant 8 coding sequence

<400> 16
Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro
 1               5                  10                  15      
Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys
            20                  25                  30          
Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr
        35                  40                  45              
Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val
    50                  55                  60                  
Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn
65                  70                  75                  80  
Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
                85                  90                  95      
Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
            100                 105                 110         
Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
        115                 120                 125             
Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn
    130                 135                 140                 
Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
145                 150                 155                 160 
Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
                165                 170                 175     
Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala Leu
            180                 185                 190         
Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
        195                 200                 205             
Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
    210                 215                 220                 
Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu
225                 230                 235                 240 
Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro
                245                 250                 255     
Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly
            260                 265                 270         
Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala
        275                 280                 285             
Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser
    290                 295                 300                 
Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu
305                 310                 315                 320 
Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile
                325                 330                 335     
Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met
            340                 345                 350         
Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys
        355                 360                 365             
Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly Gln
    370                 375                 380                 
Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys Glu
385                 390                 395                 400 
Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val Asn
                405                 410                 415     
Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser Lys
            420                 425                 430         
Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val Leu
        435                 440                 445             
Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys Val
    450                 455                 460                 
Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro Gln
465                 470                 475                 480 
Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu Arg
                485                 490                 495     
Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu Val
            500                 505                 510         
Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg Gly
        515                 520                 525             
Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys Cys
    530                 535                 540                 
Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr
545                 550                 555                 560 
Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys Asn
                565                 570                 575     
Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu Asp
            580                 585                 590         
Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val Gly
        595                 600                 605             
Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro Gly
    610                 615                 620                 
Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu Pro
625                 630                 635                 640 
Ile Met Arg Asn Pro Ile Thr Pro Thr Gly His Val Phe Gln Thr Ser
                645                 650                 655     
Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe Ser Val Phe Gly
            660                 665                 670         
Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu Asp Leu Glu Arg
        675                 680                 685             
Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser Lys Ser Leu Leu
    690                 695                 700                 
Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp Asn Lys Lys Arg
705                 710                 715                 720 
Lys Lys
        


<210> 17
<211> 2593
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(2593)
<223> 24P4C12 variant 9

<220> 
<221> CDS            
<222> (6)...(2144)

<400> 17
gagcc atg ggg gga aag cag cgg gac gag gat gac gag gcc tac ggg aag 50
      Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys
       1               5                   10                  15
 
cca gtc aaa tac gac ccc tcc ttt cga ggc ccc atc aag aac aga agc   98
Pro Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser
                 20                  25                  30
 
tgc aca gat gtc atc tgc tgc gtc ctc ttc ctg ctc ttc att cta ggt   146
Cys Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly
             35                  40                  45
 
tac atc gtg gtg ggg att gtg gcc tgg ttg tat gga gac ccc cgg caa   194
Tyr Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln
         50                  55                  60
 
gtc ctc tac ccc agg aac tct act ggg gcc tac tgt ggc atg ggg gag   242
Val Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu
     65                  70                  75
 
aac aaa gat aag ccg tat ctc ctg tac ttc aac atc ttc agc tgc atc   290
Asn Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile
 80                  85                  90                  95
 
ctg tcc agc aac atc atc tca gtt gct gag aac ggc cta cag tgc ccc   338
Leu Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro
                100                 105                 110
 
aca ccc cag gtg tgt gtg tcc tcc tgc ccg gag gac cca tgg act gtg   386
Thr Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val
            115                 120                 125
 
gga aaa aac gag ttc tca cag act gtt ggg gaa gtc ttc tat aca aaa   434
Gly Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys
        130                 135                 140
 
aac agg aac ttt tgt ctg cca ggg gta ccc tgg aat atg acg gtg atc   482
Asn Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile
    145                 150                 155
 
aca agc ctg caa cag gaa ctc tgc ccc agt ttc ctc ctc ccc tct gct   530
Thr Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala
160                 165                 170                 175
 
cca gct ctg ggg cgc tgc ttt cca tgg acc aac gtt act cca ccg gcg   578
Pro Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala
                180                 185                 190
 
ctc cca ggg atc acc aat gac acc acc ata cag cag ggg atc agc ggt   626
Leu Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly
            195                 200                 205
 
ctt att gac agc ctc aat gcc cga gac atc agt gtt aag atc ttt gaa   674
Leu Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu
        210                 215                 220
 
gat ttt gcc cag tcc tgg tat tgg att ctt gtt gcc ctg ggg gtg gct   722
Asp Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala
    225                 230                 235
 
ctg gtc ttg agc cta ctg ttt atc ttg ctt ctg cgc ctg gtg gct ggg   770
Leu Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly
240                 245                 250                 255
 
ccc ctg gtg ctg gtg ctg atc ctg gga gtg ctg ggc gtg ctg gca tac   818
Pro Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr
                260                 265                 270
 
ggc atc tac tac tgc tgg gag gag tac cga gtg ctg cgg gac aag ggc   866
Gly Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly
            275                 280                 285
 
gcc tcc atc tcc cag ctg ggt ttc acc acc aac ctc agt gcc tac cag   914
Ala Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln
        290                 295                 300
 
agc gtg cag gag acc tgg ctg gcc gcc ctg atc gtg ttg gcg gtg ctt   962
Ser Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu
    305                 310                 315
 
gaa gcc atc ctg ctg ctg atg ctc atc ttc ctg cgg cag cgg att cgt   1010
Glu Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg
320                 325                 330                 335
 
att gcc atc gcc ctc ctg aag gag gcc agc aag gct gtg gga cag atg   1058
Ile Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met
                340                 345                 350
 
atg tct acc atg ttc tac cca ctg gtc acc ttt gtc ctc ctc ctc atc   1106
Met Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile
            355                 360                 365
 
tgc att gcc tac tgg gcc atg act gct ctg tat cct ctg ccc acg cag   1154
Cys Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Pro Leu Pro Thr Gln
        370                 375                 380
 
cca gcc act ctt gga tat gtg ctc tgg gca tcc aac atc agc tcc ccc   1202
Pro Ala Thr Leu Gly Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro
    385                 390                 395
 
ggc tgt gag aaa gtg cca ata aat aca tca tgc aac ccc acg gcc cac   1250
Gly Cys Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His
400                 405                 410                 415
 
ctt gtg aac tcc tcg tgc cca ggg ctg atg tgc gtc ttc cag ggc tac   1298
Leu Val Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr
                420                 425                 430
 
tca tcc aaa ggc cta atc caa cgt tct gtc ttc aat ctg caa atc tat   1346
Ser Ser Lys Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr
            435                 440                 445
 
ggg gtc ctg ggg ctc ttc tgg acc ctt aac tgg gta ctg gcc ctg ggc   1394
Gly Val Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly
        450                 455                 460
 
caa tgc gtc ctc gct gga gcc ttt gcc tcc ttc tac tgg gcc ttc cac   1442
Gln Cys Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His
    465                 470                 475
 
aag ccc cag gac atc cct acc ttc ccc tta atc tct gcc ttc atc cgc   1490
Lys Pro Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg
480                 485                 490                 495
 
aca ctc cgt tac cac act ggg tca ttg gca ttt gga gcc ctc atc ctg   1538
Thr Leu Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu
                500                 505                 510
 
acc ctt gtg cag ata gcc cgg gtc atc ttg gag tat att gac cac aag   1586
Thr Leu Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys
            515                 520                 525
 
ctc aga gga gtg cag aac cct gta gcc cgc tgc atc atg tgc tgt ttc   1634
Leu Arg Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe
        530                 535                 540
 
aag tgc tgc ctc tgg tgt ctg gaa aaa ttt atc aag ttc cta aac cgc   1682
Lys Cys Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg
    545                 550                 555
 
aat gca tac atc atg atc gcc atc tac ggg aag aat ttc tgt gtc tca   1730
Asn Ala Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser
560                 565                 570                 575
 
gcc aaa aat gcg ttc atg cta ctc atg cga aac att gtc agg gtg gtc   1778
Ala Lys Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val
                580                 585                 590
 
gtc ctg gac aaa gtc aca gac ctg ctg ctg ttc ttt ggg aag ctg ctg   1826
Val Leu Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu
            595                 600                 605
 
gtg gtc gga ggc gtg ggg gtc ctg tcc ttc ttt ttt ttc tcc ggt cgc   1874
Val Val Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg
        610                 615                 620
 
atc ccg ggg ctg ggt aaa gac ttt aag agc ccc cac ctc aac tat tac   1922
Ile Pro Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr
    625                 630                 635
 
tgg ctg ccc atc atg acc tcc atc ctg ggg gcc tat gtc atc gcc agc   1970
Trp Leu Pro Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser
640                 645                 650                 655
 
ggc ttc ttc agc gtt ttc ggc atg tgt gtg gac acg ctc ttc ctc tgc   2018
Gly Phe Phe Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys
                660                 665                 670
 
ttc ctg gaa gac ctg gag cgg aac aac ggc tcc ctg gac cgg ccc tac   2066
Phe Leu Glu Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr
            675                 680                 685
 
tac atg tcc aag agc ctt cta aag att ctg ggc aag aag aac gag gcg   2114
Tyr Met Ser Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala
        690                 695                 700
 
ccc ccg gac aac aag aag agg aag aag tga cagctccggc cctgatccag     2164
Pro Pro Asp Asn Lys Lys Arg Lys Lys  *
    705                 710
 
gactgcaccc cacccccacc gtccagccat ccaacctcac ttcgccttac aggtctccat 2224
tttgtggtaa aaaaaggttt taggccaggc gccgtggctc acgcctgtaa tccaacactt 2284
tgagaggctg aggcgggcgg atcacctgag tcaggagttc gagaccagcc tggccaacat 2344
ggtgaaacct ccgtctctat taaaaataca aaaattagcc gagagtggtg gcatgcacct 2404
gtcatcccag ctactcggga ggctgaggca ggagaatcgc ttgaacccgg gaggcagagg 2464
ttgcagtgag ccgagatcgc gccactgcac tccaacctgg gtgacagact ctgtctccaa 2524
aacaaaacaa acaaacaaaa agattttatt aaagatattt tgttaactca gtaaaaaaaa 2584
aaaaaaaaa                                                         2593

<210> 18
<211> 712
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(712)
<223> 24P4C12 variant 9 coding sequence

<400> 18
Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro
 1               5                  10                  15      
Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys
            20                  25                  30          
Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr
        35                  40                  45              
Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val
    50                  55                  60                  
Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn
65                  70                  75                  80  
Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
                85                  90                  95      
Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
            100                 105                 110         
Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
        115                 120                 125             
Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn
    130                 135                 140                 
Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
145                 150                 155                 160 
Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
                165                 170                 175     
Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala Leu
            180                 185                 190         
Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
        195                 200                 205             
Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
    210                 215                 220                 
Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu
225                 230                 235                 240 
Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro
                245                 250                 255     
Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly
            260                 265                 270         
Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala
        275                 280                 285             
Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser
    290                 295                 300                 
Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu
305                 310                 315                 320 
Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile
                325                 330                 335     
Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met
            340                 345                 350         
Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys
        355                 360                 365             
Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Pro Leu Pro Thr Gln Pro
    370                 375                 380                 
Ala Thr Leu Gly Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly
385                 390                 395                 400 
Cys Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu
                405                 410                 415     
Val Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser
            420                 425                 430         
Ser Lys Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly
        435                 440                 445             
Val Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln
    450                 455                 460                 
Cys Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys
465                 470                 475                 480 
Pro Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr
                485                 490                 495     
Leu Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr
            500                 505                 510         
Leu Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu
        515                 520                 525             
Arg Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys
    530                 535                 540                 
Cys Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn
545                 550                 555                 560 
Ala Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala
                565                 570                 575     
Lys Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val
            580                 585                 590         
Leu Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val
        595                 600                 605             
Val Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile
    610                 615                 620                 
Pro Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp
625                 630                 635                 640 
Leu Pro Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly
                645                 650                 655     
Phe Phe Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe
            660                 665                 670         
Leu Glu Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr
        675                 680                 685             
Met Ser Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro
    690                 695                 700                 
Pro Asp Asn Lys Lys Arg Lys Lys
705                 710         


<210> 19
<211> 1410
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(1410)
<223> Ha5-1(5)2.1 heavy chain

<220> 
<221> CDS            
<222> (1)...(1410)

<220> 
<221> SITE               
<222> (1)...(57)
<223> leader sequence

<220> 
<221> SITE                
<222> (58)...(429)
<223> heavy chain variable region

<220> 
<221> SITE               
<222> (430)...(1410)
<223> human IgG2 constant region

<400> 19
atg gag ttt ggg ctg acc tgg gtt ttc ctc gtt gct ctt tta aga ggt   48
Met Glu Phe Gly Leu Thr Trp Val Phe Leu Val Ala Leu Leu Arg Gly
 1               5                   10                  15
 
gtc cag tgt cag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag   96
Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln
             20                  25                  30
 
cct ggg agg tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc   144
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
         35                  40                  45
 
agt agt tat ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg   192
Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
     50                  55                  60
 
gag tgg gtg gca gtt atg tca tat gat gga agt aaa aaa ttc tat aca   240
Glu Trp Val Ala Val Met Ser Tyr Asp Gly Ser Lys Lys Phe Tyr Thr
 65                  70                  75                  80
 
gac tcc gtg aag ggc cga ttc acc atc tcc aga gac aat tcc aag aac   288
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
                 85                  90                  95
 
acg ctg tat ctg caa atg aac agc ctg aga gct gag gac acg gct gtg   336
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
            100                 105                 110
 
tat tac tgt gcg aga gat ggg ggt gac tat gtc cgc tac cac tac tac   384
Tyr Tyr Cys Ala Arg Asp Gly Gly Asp Tyr Val Arg Tyr His Tyr Tyr
        115                 120                 125
 
ggt atg gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc tca gcc   432
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
    130                 135                 140
 
tcc acc aag ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg agc   480
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser
145                 150                 155                 160
 
acc tcc gag agc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc   528
Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                165                 170                 175
 
ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gct ctg acc agc ggc   576
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
            180                 185                 190
 
gtg cac acc ttc cca gct gtc cta cag tcc tca gga ctc tac tcc ctc   624
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
        195                 200                 205
 
agc agc gtg gtg acc gtg ccc tcc agc aac ttc ggc acc cag acc tac   672
Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr
    210                 215                 220
 
acc tgc aac gta gat cac aag ccc agc aac acc aag gtg gac aag aca   720
Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr
225                 230                 235                 240
 
gtt gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc cca gca cca cct   768
Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro
                245                 250                 255
 
gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc   816
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            260                 265                 270
 
ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg   864
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        275                 280                 285
 
agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg   912
Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
    290                 295                 300
 
gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac agc   960
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
305                 310                 315                 320
 
acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg   1008
Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu
                325                 330                 335
 
aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc   1056
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala
            340                 345                 350
 
ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca   1104
Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro
        355                 360                 365
 
cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag   1152
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln
    370                 375                 380
 
gtc agc ctg acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc gcc   1200
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
385                 390                 395                 400
 
gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc aca   1248
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                405                 410                 415
 
cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctt tac agc aag ctc   1296
Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
            420                 425                 430
 
acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc   1344
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
        435                 440                 445
 
gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc   1392
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    450                 455                 460
 
ctg tct ccg ggt aaa tga                                           1410
Leu Ser Pro Gly Lys  *
465
 

<210> 20
<211> 469
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(469)
<223> Ha5-1(5)2.1 heavy chain coding sequence

<400> 20
Met Glu Phe Gly Leu Thr Trp Val Phe Leu Val Ala Leu Leu Arg Gly
 1               5                  10                  15      
Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln
            20                  25                  30          
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
        35                  40                  45              
Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ala Val Met Ser Tyr Asp Gly Ser Lys Lys Phe Tyr Thr
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Gly Gly Asp Tyr Val Arg Tyr His Tyr Tyr
        115                 120                 125             
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
    130                 135                 140                 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser
145                 150                 155                 160 
Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                165                 170                 175     
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
            180                 185                 190         
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
        195                 200                 205             
Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr
    210                 215                 220                 
Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr
225                 230                 235                 240 
Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro
                245                 250                 255     
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            260                 265                 270         
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        275                 280                 285             
Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
    290                 295                 300                 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
305                 310                 315                 320 
Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu
                325                 330                 335     
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala
            340                 345                 350         
Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro
        355                 360                 365             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln
    370                 375                 380                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
385                 390                 395                 400 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                405                 410                 415     
Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
            420                 425                 430         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
        435                 440                 445             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    450                 455                 460                 
Leu Ser Pro Gly Lys
465                 


<210> 21
<211> 711
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(711)
<223> Ha5-1(5)2.1 light chain

<220> 
<221> CDS            
<222> (1)...(711)

<220> 
<221> SITE               
<222> (1)...(66)
<223> leader sequence

<220> 
<221> SITE                
<222> (67)...(390)
<223> light chain variable region

<220> 
<221> SITE               
<222> (391)...(711)
<223> human kappa constant region

<400> 21
atg gac atg agg gtc cct gct cag ctc ctg gga ctc ctg ctg ctc tgg   48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                   10                  15
 
ctc cca gat acc aga tgt gac atc cag atg acc cag tct cca tcc acc   96
Leu Pro Asp Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr
             20                  25                  30
 
ctg tct gca tct ata gga gac aga gtc acc atc act tgc cgg gcg agt   144
Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
         35                  40                  45
 
cag ggc att agc tat tat tta gcc tgg tat cag cag aaa ccg ggg aaa   192
Gln Gly Ile Ser Tyr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys
     50                  55                  60
 
att cct aag ctc ctg atc tat gat aca tcc tct ttg caa tca ggg gtc   240
Ile Pro Lys Leu Leu Ile Tyr Asp Thr Ser Ser Leu Gln Ser Gly Val
 65                  70                  75                  80
 
cca tct cga ttc agt ggc agt aga tct ggg aca gat ctc tct ctc acc   288
Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Leu Ser Leu Thr
                 85                  90                  95
 
atc agc agc ctg cag cct gaa gat gtt gca act tat tac tgt caa agg   336
Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg
            100                 105                 110
 
tat gac agt gcc ccg ctc act ttc ggc gga ggg acc aag gtg gag atc   384
Tyr Asp Ser Ala Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
        115                 120                 125
 
aaa cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat   432
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
    130                 135                 140
 
gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac   480
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
145                 150                 155                 160
 
ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc   528
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
                165                 170                 175
 
caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac   576
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
            180                 185                 190
 
agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac   624
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
        195                 200                 205
 
gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc   672
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
    210                 215                 220
 
tcg ccc gtc aca aag agc ttc aac agg gga gag tgt tag               711
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys  *
225                 230                 235
 

<210> 22
<211> 236
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(236)
<223> Ha5-1(5)2.1 light chain coding sequence

<400> 22
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Leu Pro Asp Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr
            20                  25                  30          
Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Gly Ile Ser Tyr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ile Pro Lys Leu Leu Ile Tyr Asp Thr Ser Ser Leu Gln Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Leu Ser Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg
            100                 105                 110         
Tyr Asp Ser Ala Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235     


<210> 23
<211> 469
<212> PRT
<213> Homo sapiens

<220> 
<221> SITE                
<222> (1)...(469)
<223> Ha5-1(5)2.1 heavy chain

<220> 
<221> SITE           
<222> (1)...(19)
<223> leader sequence

<220> 
<221> SITE           
<222> (20)...(143)
<223> heavy chain variable region

<220> 
<221> SITE           
<222> (144)...(469)
<223> human IgG2 constant region

<400> 23
Met Glu Phe Gly Leu Thr Trp Val Phe Leu Val Ala Leu Leu Arg Gly
 1               5                  10                  15      
Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln
            20                  25                  30          
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
        35                  40                  45              
Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ala Val Met Ser Tyr Asp Gly Ser Lys Lys Phe Tyr Thr
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Gly Gly Asp Tyr Val Arg Tyr His Tyr Tyr
        115                 120                 125             
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
    130                 135                 140                 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser
145                 150                 155                 160 
Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                165                 170                 175     
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
            180                 185                 190         
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
        195                 200                 205             
Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr
    210                 215                 220                 
Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr
225                 230                 235                 240 
Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro
                245                 250                 255     
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            260                 265                 270         
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        275                 280                 285             
Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
    290                 295                 300                 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
305                 310                 315                 320 
Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu
                325                 330                 335     
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala
            340                 345                 350         
Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro
        355                 360                 365             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln
    370                 375                 380                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
385                 390                 395                 400 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                405                 410                 415     
Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
            420                 425                 430         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
        435                 440                 445             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    450                 455                 460                 
Leu Ser Pro Gly Lys
465                 


<210> 24
<211> 236
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(236)
<223> Ha5-1(5)2.1 light chain

<220> 
<221> SITE           
<222> (1)...(12)
<223> leader sequence

<220> 
<221> SITE           
<222> (13)...(130)
<223> light chain variable region

<220> 
<221> SITE           
<222> (131)...(236)
<223> human kappa constant region

<400> 24
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Leu Pro Asp Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr
            20                  25                  30          
Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Gly Ile Ser Tyr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ile Pro Lys Leu Leu Ile Tyr Asp Thr Ser Ser Leu Gln Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Leu Ser Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg
            100                 105                 110         
Tyr Asp Ser Ala Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235     


<210> 25
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetically constructed linker

<400> 25
Gly Phe Leu Gly
 1              

