                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       UNIVERSITE PARIS DIDEROT - PARIS 7
 
<120>  KANAMYCIN ANTISENSE NUCLEIC ACID FOR THE TREATMENT OF CANCER

<130>  BET 10P0394

<150>  EP 09290224.6
<151>  2009-03-27

<160>  23    

<170>  PatentIn version 3.4

<210>  1
<211>  473
<212>  DNA
<213>  Artificial

<220>
<223>  KanAS construct


<220>
<221>  misc_feature
<222>  (1)..(473)
<223>  Sequence complementary to a fragment of the sequence coding for 
       the kanamycin resistance protein

<400>  1
agatcatcct gatcgacaag accggcttcc atccgagtac gtgctcgctc gatgcgatgt     60

ttcgcttggt ggtcgaatgg gcaggtagcc ggatcaagcg tatgcagccg ccgcattgca    120

tcagccatga tggatacttt ctcggcagga gcaaggtgag atgacaggag atcctgcccc    180

ggcacttcgc ccaatagcag ccagtccctt cccgcttcag tgacaacgtc gagcacagct    240

gcgcaaggaa cgcccgtcgt ggccagccac gatagccgcg ctgcctcgtc ttgcagttca    300

ttcagggcac cggacaggtc ggtcttgaca aaaagaaccg ggcgcccctg cgctgacagc    360

cggaacacgg cggcatcaga gcagccgatt gtctgttgtg cccagtcata gccgaatagc    420

ctctccaccc aagcggccgg agaacctgcg tgcaatccat cttgttcaat cat           473


<210>  2
<211>  573
<212>  DNA
<213>  Artificial

<220>
<223>  KanAS construct


<220>
<221>  misc_feature
<222>  (1)..(473)
<223>  Sequence complementary to a fragment of the sequence coding for 
       the kanamycin resistance protein

<220>
<221>  misc_feature
<222>  (474)..(573)
<223>  Sequence complementary to a fragment of the pVax plasmid

<400>  2
agatcatcct gatcgacaag accggcttcc atccgagtac gtgctcgctc gatgcgatgt     60

ttcgcttggt ggtcgaatgg gcaggtagcc ggatcaagcg tatgcagccg ccgcattgca    120

tcagccatga tggatacttt ctcggcagga gcaaggtgag atgacaggag atcctgcccc    180

ggcacttcgc ccaatagcag ccagtccctt cccgcttcag tgacaacgtc gagcacagct    240

gcgcaaggaa cgcccgtcgt ggccagccac gatagccgcg ctgcctcgtc ttgcagttca    300

ttcagggcac cggacaggtc ggtcttgaca aaaagaaccg ggcgcccctg cgctgacagc    360

cggaacacgg cggcatcaga gcagccgatt gtctgttgtg cccagtcata gccgaatagc    420

ctctccaccc aagcggccgg agaacctgcg tgcaatccat cttgttcaat catgcgaaac    480

gatcctcatc ctgtctcttg atcagagctt gatcccctgc gccatcanat ccttggcggc    540

aagaaagcca tccantttac tttgcagggn ctt                                 573


<210>  3
<211>  584
<212>  DNA
<213>  Artificial

<220>
<223>  PML-RARalphaKanAS construct


<220>
<221>  misc_feature
<222>  (1)..(105)
<223>  PML-RARalpha

<220>
<221>  misc_feature
<222>  (112)..(584)
<223>  Sequence complementary to a fragment of the sequence coding for 
       the kanamycin resistance protein

<400>  3
gaggtcttcc tgcccaacag caaccacgtg gccagtggcg ccggggaggc agccattgag     60

acccagagca gcagttctga agagatagtg cccagccctc cctcgggatc cagatcatcc    120

tgatcgacaa gaccggcttc catccgagta cgtgctcgct cgatgcgatg tttcgcttgg    180

tggtcgaatg ggcaggtagc cggatcaagc gtatgcagcc gccgcattgc atcagccatg    240

atggatactt tctcggcagg agcaaggtga gatgacagga gatcctgccc cggcacttcg    300

cccaatagca gccagtccct tcccgcttca gtgacaacgt cgagcacagc tgcgcaagga    360

acgcccgtcg tggccagcca cgatagccgc gctgcctcgt cttgcagttc attcagggca    420

ccggacaggt cggtcttgac aaaaagaacc gggcgcccct gcgctgacag ccggaacacg    480

gcggcatcag agcagccgat tgtctgttgt gcccagtcat agccgaatag cctctccacc    540

caagcggccg gagaacctgc gtgcaatcca tcttgttcaa tcat                     584


<210>  4
<211>  684
<212>  DNA
<213>  Artificial

<220>
<223>  PML-RARalphaKanAS construct


<220>
<221>  misc_feature
<222>  (1)..(105)
<223>  PML-RARalpha

<220>
<221>  misc_feature
<222>  (112)..(584)
<223>  Sequence complementary to a fragment of the sequence coding for 
       the kanamycin resistance protein

<220>
<221>  misc_feature
<222>  (585)..(684)
<223>  Sequence complementary to a fragment of the pVax plasmid

<400>  4
gaggtcttcc tgcccaacag caaccacgtg gccagtggcg ccggggaggc agccattgag     60

acccagagca gcagttctga agagatagtg cccagccctc cctcgggatc cagatcatcc    120

tgatcgacaa gaccggcttc catccgagta cgtgctcgct cgatgcgatg tttcgcttgg    180

tggtcgaatg ggcaggtagc cggatcaagc gtatgcagcc gccgcattgc atcagccatg    240

atggatactt tctcggcagg agcaaggtga gatgacagga gatcctgccc cggcacttcg    300

cccaatagca gccagtccct tcccgcttca gtgacaacgt cgagcacagc tgcgcaagga    360

acgcccgtcg tggccagcca cgatagccgc gctgcctcgt cttgcagttc attcagggca    420

ccggacaggt cggtcttgac aaaaagaacc gggcgcccct gcgctgacag ccggaacacg    480

gcggcatcag agcagccgat tgtctgttgt gcccagtcat agccgaatag cctctccacc    540

caagcggccg gagaacctgc gtgcaatcca tcttgttcaa tcatgcgaaa cgatcctcat    600

cctgtctctt gatcagagct tgatcccctg cgccatcana tccttggcgg caagaaagcc    660

atccanttta ctttgcaggg nctt                                           684


<210>  5
<211>  105
<212>  DNA
<213>  Artificial

<220>
<223>  PML-RARalpha

<400>  5
gaggtcttcc tgcccaacag caaccacgtg gccagtggcg ccggggaggc agccattgag     60

acccagagca gcagttctga agagatagtg cccagccctc cctcg                    105


<210>  6
<211>  105
<212>  DNA
<213>  Artificial

<220>
<223>  PML-RARalphaAS

<400>  6
cgagggaggg ctgggcacta tctcttcaga actgctgctc tgggtctcaa tggctgcctc     60

cccggcgcca ctggccacgt ggttgctgtt gggcaggaag acctc                    105


<210>  7
<211>  627
<212>  DNA
<213>  Artificial

<220>
<223>  Fragment of pVax14


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(36)
<223>  HindIII restriction site

<220>
<221>  misc_feature
<222>  (49)..(54)
<223>  BamHI restriction site

<220>
<221>  misc_feature
<222>  (55)..(527)
<223>  KanAS

<220>
<221>  misc_feature
<222>  (528)..(627)
<223>  pVaxAS

<400>  7
gagacccaag nctggctagc gtttaaactt aagcttggta ccgagctcgg atccagatca     60

tcctgatcga caagaccggc ttccatccga gtacgtgctc gctcgatgcg atgtttcgct    120

tggtggtcga atgggcaggt agccggatca agcgtatgca gccgccgcat tgcatcagcc    180

atgatggata ctttctcggc aggagcaagg tgagatgaca ggagatcctg ccccggcact    240

tcgcccaata gcagccagtc ccttcccgct tcagtgacaa cgtcgagcac agctgcgcaa    300

ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct cgtcttgcag ttcattcagg    360

gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc cctgcgctga cagccggaac    420

acggcggcat cagagcagcc gattgtctgt tgtgcccagt catagccgaa tagcctctcc    480

acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt caatcatgcg aaacgatcct    540

catcctgtct cttgatcaga gcttgatccc ctgcgccatc anatccttgg cggcaagaaa    600

gccatccant ttactttgca gggnctt                                        627


<210>  8
<211>  770
<212>  DNA
<213>  Artificial

<220>
<223>  Fragment of pVax15


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (11)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (24)..(29)
<223>  HindIII restriction site

<220>
<221>  misc_feature
<222>  (30)..(86)
<223>  Leader sequence

<220>
<221>  misc_feature
<222>  (87)..(191)
<223>  PML-RARalpha

<220>
<221>  misc_feature
<222>  (192)..(197)
<223>  BamHI restriction site

<220>
<221>  misc_feature
<222>  (198)..(670)
<223>  KanAS

<220>
<221>  misc_feature
<222>  (671)..(770)
<223>  pVaxAS

<400>  8
nnnnnnnntg nnnnnnnnnn nnnaagctta tggactggac ctggagggtc ttctgcttgc     60

tggctgtggc cccgggggcc cactccgagg tcttcctgcc caacagcaac cacgtggcca    120

gtggcgccgg ggaggcagcc attgagaccc agagcagcag ttctgaagag atagtgccca    180

gccctccctc gggatccaga tcatcctgat cgacaagacc ggcttccatc cgagtacgtg    240

ctcgctcgat gcgatgtttc gcttggtggt cgaatgggca ggtagccgga tcaagcgtat    300

gcagccgccg cattgcatca gccatgatgg atactttctc ggcaggagca aggtgagatg    360

acaggagatc ctgccccggc acttcgccca atagcagcca gtcccttccc gcttcagtga    420

caacgtcgag cacagctgcg caaggaacgc ccgtcgtggc cagccacgat agccgcgctg    480

cctcgtcttg cagttcattc agggcaccgg acaggtcggt cttgacaaaa agaaccgggc    540

gcccctgcgc tgacagccgg aacacggcgg catcagagca gccgattgtc tgttgtgccc    600

agtcatagcc gaatagcctc tccacccaag cggccggaga acctgcgtgc aatccatctt    660

gttcaatcat gcgaaacgat cctcatcctg tctcttgatc agagcttgat cccctgcgcc    720

atcanatcct tggcggcaag aaagccatcc antttacttt gcagggnctt               770


<210>  9
<211>  2999
<212>  DNA
<213>  Artificial

<220>
<223>  pVax1 vector


<220>
<221>  promoter
<222>  (137)..(724)
<223>  CMV promoter

<220>
<221>  promoter
<222>  (664)..(683)
<223>  T7 promoter/priming site

<220>
<221>  misc_feature
<222>  (696)..(811)
<223>  Multiple cloning site

<220>
<221>  misc_feature
<222>  (1226)..(2020)
<223>  sequence coding for the kanamycin resistance protein

<220>
<221>  rep_origin
<222>  (2320)..(2993)
<223>  pUC origin

<400>  9
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta     60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata    120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat    180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga    240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc    300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt    360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat    420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag    480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc    540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga    600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga    660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt    720

accgagctcg gatccactag tccagtgtgg tggaattctg cagatatcca gcacagtggc    780

ggccgctcga gtctagaggg cccgtttaaa cccgctgatc agcctcgact gtgccttcta    840

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca    900

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc    960

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata   1020

gcaggcatgc tggggatgcg gtgggctcta tggcttctac tgggcggttt tatggacagc   1080

aagcgaaccg gaattgccag ctggggcgcc ctctggtaag gttgggaagc cctgcaaagt   1140

aaactggatg gctttctcgc cgccaaggat ctgatggcgc aggggatcaa gctctgatca   1200

agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg caggttctcc   1260

ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa tcggctgctc   1320

tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg tcaagaccga   1380

cctgtccggt gccctgaatg aactgcaaga cgaggcagcg cggctatcgt ggctggccac   1440

gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa gggactggct   1500

gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc ctgccgagaa   1560

agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg ctacctgccc   1620

attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg aagccggtct   1680

tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg aactgttcgc   1740

caggctcaag gcgagcatgc ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg   1800

cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact gtggccggct   1860

gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg ctgaagagct   1920

tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc ccgattcgca   1980

gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga attattaacg cttacaattt   2040

cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca tacaggtggc   2100

acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat   2160

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatagca cgtgctaaaa   2220

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa   2280

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga   2340

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg   2400

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact   2460

ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac   2520

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg   2580

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg   2640

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga   2700

acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc   2760

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg   2820

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc   2880

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc   2940

agcaacgcgg cctttttacg gttcctgggc ttttgctggc cttttgctca catgttctt    2999


<210>  10
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  10
acgtctcttc cgcggccgct cgagtctaga g                                    31


<210>  11
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  11
acgtctcttc cggatccgag ctcggtacca ag                                   32


<210>  12
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  12
acgtctcttc ctccatggac tggacctgga gggtc                                35


<210>  13
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  13
acgtctcttc ccgcttagtc gttggtccaa cc                                   32


<210>  14
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  14
cgaagcttat ggactggacc tggagggtct                                      30


<210>  15
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  15
cgggatcccg agggagggct gggcacta                                        28


<210>  16
<211>  1360
<212>  DNA
<213>  Clostridium tetani


<220>
<221>  misc_feature
<222>  (1)..(1360)
<223>  FrC sequence

<400>  16
atgaaaaacc ttgattgttg ggtcgacaac gaagaagaca tcgatgttat cctgaaaaag     60

tctaccattc tgaacttgga catcaacaac gatattatct ccgacatctc tggtttcaac    120

tcctctgtta tcacatatcc agatgctcaa ttggtgccgg gcatcaacgg caaagctatc    180

cacctggtta acaacgaatc ttctgaagtt atcgtgcaca aggccatgga catcgaatac    240

aacgacatgt tcaacaactt caccgttagc ttctggctgc gcgttccgaa agtttctgct    300

tcccacctgg aacagtacgg cactaacgag tactccatca tcagctctat gaagaaacac    360

tccctgtcca tcggctctgg ttggtctgtt tccctgaagg gtaacaacct gatctggact    420

ctgaaagact ccgcgggcga agttcgtcag atcactttcc gcgacctgcc ggacaagttc    480

aacgcgtacc tggctaacaa atgggttttc atcactatca ctaacgatcg tctgtcttct    540

gctaacctgt acatcaacgg cgttctgatg ggctccgctg aaatcactgg tctgggcgct    600

atccgtgagg acaacaacat cactcttaag ctgaaccgtg gcaacaacaa caaccactac    660

gtatccatcg acaagttccg tatcttctgc aaagcactga acccgaaaga gatcgaaaaa    720

ctgtatacca gctacctgtc tatcaccttc ctgcgtgact tctggggtaa cccgctgcgt    780

tacgacaccg aatattacct gatcccggta gcttctagct ctaaagacgt tcagctgaaa    840

aacatcactg actacatgta cctgacccac gcgccgtcct acactaacgg taaactgaac    900

atctactacc gacgtctgta caacggcctg aaaatcatca tcaaacgcta cactccgaac    960

aacgaaatcg attctttcgt taaatctggt gacttcatca aactgtacgt ttcttacaac   1020

aacaacgaac acatcgttgg ttacccgaaa gacggtaacg tctttcaaca acctggacag   1080

aattctgcgt gttggttaca acgctccggg tatcccgctg tacaaaaaaa gggaagctgt   1140

taaactgcgt gacctgaaaa cctactctgt tcagctgaaa ctgtacgacg acaaaaacgc   1200

ttctctgggt ctggttggta cccacaacgg tcagatcggt aacgacccga accgtgacat   1260

cctgatcgct tctaactggt acttcaacca cctgaaagac aaaatcctgg gttgcgactg   1320

gtacttcgtt ccgaccgatg aaggttggac caacgactag                         1360


<210>  17
<211>  3540
<212>  DNA
<213>  Artificial

<220>
<223>  pVax14


<220>
<221>  misc_feature
<222>  (762)..(1587)
<223>  Flipper region, which comprises a sequence complementary to a 
       fragment of the sequence coding for the kanamycin resistance 
       protein

<220>
<221>  misc_feature
<222>  (1816)..(2610)
<223>  Sequence coding for the kanamycin resistance protein

<400>  17
tgctggcctt ttgctcacat gttcttgctg cttcgcgatg tacgggccag atatacgcgt     60

tgacattgat tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc    120

ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc    180

aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg    240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat    300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc    360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta    420

ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag    480

cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt    540

tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa    600

atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctctctg gctaactaga    660

gaacccactg cttactggct tatcgaaatt aatacgactc actataggga gacccaagct    720

ggctagcgtt taaacttaag cttggtaccg agctcggatc cagatcatcc tgatcgacaa    780

gaccggcttc catccgagta cgtgctcgct cgatgcgatg tttcgcttgg tggtcgaatg    840

ggcaggtagc cggatcaagc gtatgcagcc gccgcattgc atcagccatg atggatactt    900

tctcggcagg agcaaggtga gatgacagga gatcctgccc cggcacttcg cccaatagca    960

gccagtccct tcccgcttca gtgacaacgt cgagcacagc tgcgcaagga acgcccgtcg   1020

tggccagcca cgatagccgc gctgcctcgt cttgcagttc attcagggca ccggacaggt   1080

cggtcttgac aaaaagaacc gggcgcccct gcgctgacag ccggaacacg gcggcatcag   1140

agcagccgat tgtctgttgt gcccagtcat agccgaatag cctctccacc caagcggccg   1200

gagaacctgc gtgcaatcca tcttgttcaa tcatgcgaaa cgatcctcat cctgtctctt   1260

gatcagagct tgatcccctg cgccatcaga tccttggcgg cgagaaagcc atccagttta   1320

ctttgcaggg cttcccaacc ttaccagagg gcgccccagc tggcaattcc ggttcgcttg   1380

ctgtccataa aaccgcccag tagaagccat agagcccacc gcatccccag catgcctgct   1440

attgtcttcc caatcctccc ccttgctgtc ctgccccacc ccacccccca gaatagaatg   1500

acacctactc agacaatgcg atgcaatttc ctcattttat taggaaagga cagtgggagt   1560

ggcaccttcc agggtcaagg aaggcacggg ggaggattgg gaagacaata gcaggcatgc   1620

tggggatgcg gtgggctcta tggcttctac tgggcggttt tatggacagc aagcgaaccg   1680

gaattgccag ctggggcgcc ctctggtaag gttgggaagc cctgcaaagt aaactggatg   1740

gctttcttgc cgccaaggat ctgatggcgc aggggatcaa gctctgatca agagacagga   1800

tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg caggttctcc ggccgcttgg   1860

gtggagaggc tattcggcta tgactgggca caacagacaa tcggctgctc tgatgccgcc   1920

gtgttccggc tgtcagcgca ggggcgcccg gttctttttg tcaagaccga cctgtccggt   1980

gccctgaatg aactgcaaga cgaggcagcg cggctatcgt ggctggccac gacgggcgtt   2040

ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa gggactggct gctattgggc   2100

gaagtgccgg ggcaggatct cctgtcatct caccttgctc ctgccgagaa agtatccatc   2160

atggctgatg caatgcggcg gctgcatacg cttgatccgg ctacctgccc attcgaccac   2220

caagcgaaac atcgcatcga gcgagcacgt actcggatgg aagccggtct tgtcgatcag   2280

gatgatctgg acgaagagca tcaggggctc gcgccagccg aactgttcgc caggctcaag   2340

gcgagcatgc ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat   2400

atcatggtgg aaaatggccg cttttctgga ttcatcgact gtggccggct gggtgtggcg   2460

gaccgctatc aggacatagc gttggctacc cgtgatattg ctgaagagct tggcggcgaa   2520

tgggctgacc gcttcctcgt gctttacggt atcgccgctc ccgattcgca gcgcatcgcc   2580

ttctatcgcc ttcttgacga gttcttctga attattaacg cttacaattt cctgatgcgg   2640

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tacaggtggc acttttcggg   2700

gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc   2760

tcatgagaca ataaccctga taaatgcttc aataatagca cgtgctaaaa cttcattttt   2820

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac   2880

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag   2940

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg   3000

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca   3060

gagcgcagat accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga   3120

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca   3180

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc   3240

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca   3300

ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa   3360

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc   3420

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc   3480

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg aaaaacgcca gcaacgcggc   3540


<210>  18
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic polypeptide

<400>  18

Met Arg Cys Phe Ala Trp Trp Ser Asn Gly Gln Val Ala Gly Ser Ser 
1               5                   10                  15      


Val Cys Ser Arg Arg Ile Ala Ser Ala Met Met Asp Thr Phe Ser Ala 
            20                  25                  30          


Gly Ala Arg 
        35  


<210>  19
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic polypeptide

<400>  19

Met Phe Arg Leu Val Val Glu Trp Ala Gly Ser Arg Ile Lys Arg Met 
1               5                   10                  15      


Gln Pro Pro His Cys Ile Ser His Asp Gly Tyr Phe Leu Gly Arg Ser 
            20                  25                  30          


Lys Val Arg 
        35  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic polypeptide

<400>  20

Met Thr Gly Asp Pro Ala Pro Ala Leu Arg Pro Ile Ala Ala Ser Pro 
1               5                   10                  15      


Phe Pro Leu Gln 
            20  


<210>  21
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic polypeptide

<400>  21

Met Arg Asn Asp Pro His Pro Val Ser 
1               5                   


<210>  22
<211>  59
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic polypeptide

<400>  22

Met Pro Ala Ile Val Phe Pro Ile Leu Pro Leu Ala Val Leu Pro His 
1               5                   10                  15      


Pro Thr Pro Gln Asn Arg Met Thr Pro Thr Gln Thr Met Arg Cys Asn 
            20                  25                  30          


Phe Leu Ile Leu Leu Gly Lys Asp Ser Gly Ser Gly Thr Phe Gln Gly 
        35                  40                  45              


Gln Gly Arg His Gly Gly Gly Leu Gly Arg Gln 
    50                  55                  


<210>  23
<211>  62
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic polypeptide

<400>  23

Met Gln Phe Pro His Phe Ile Arg Lys Gly Gln Trp Glu Trp His Leu 
1               5                   10                  15      


Pro Gly Ser Arg Lys Ala Arg Gly Arg Ile Gly Lys Thr Ile Ala Gly 
            20                  25                  30          


Met Leu Gly Met Arg Trp Ala Leu Trp Leu Leu Leu Gly Gly Phe Met 
        35                  40                  45              


Asp Ser Lys Arg Thr Gly Ile Ala Ser Trp Gly Ala Leu Trp 
    50                  55                  60          


