                         SEQUENCE LISTING

<110>  AMGEN INC.
 
<120>  CARRIER IMMUNOGLOBULINS AND USES THEREOF

<130>  A-1537-WO-PCT

<140>  XX/XX XX/XXXXXX
<141>  2010-03-19

<150>  61/210,594
<151>  2009-03-20

<160>  368   

<170>  PatentIn version 3.4

<210>  1
<211>  245
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Immunoglobulin Fc domain of human IgG2

<400>  1

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Arg Lys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            20                  25                  30          


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys 
                245 


<210>  2
<211>  19
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Modifed VH21signal peptide

<400>  2

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  3
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  3
catgaattcc ccaccatgga atggagctgg                                      30


<210>  4
<211>  38
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  4
cacggtgggc actcgacttt gcgctcggag tggacacc                             38


<210>  5
<211>  132
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ShK[2-35] with N-terminal linker extension

<400>  5
ggaggaggag gatccggagg aggaggaagc agctgcatcg acaccatccc caagagccgc     60

tgcaccgcct tccagtgcaa gcacagcatg aagtaccgcc tgagcttctg ccgcaagacc    120

tgcggcacct gc                                                        132


<210>  6
<211>  44
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ShK[2-35] with N-terminal linker extension

<400>  6

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Cys Ile Asp Thr Ile 
1               5                   10                  15      


Pro Lys Ser Arg Cys Thr Ala Phe Gln Cys Lys His Ser Met Lys Tyr 
            20                  25                  30          


Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
        35                  40                  


<210>  7
<211>  37
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  7
gtccactccg agcgcaaagt cgagtgccca ccgtgcc                              37


<210>  8
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  8
tcctcctcct ttacccggag acagggagag                                      30


<210>  9
<211>  29
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  9
gctgcaccgc cttcaagtgc aagcacagc                                       29


<210>  10
<211>  29
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  10
gctgtgcttg cacttgaagg cggtgcagc                                       29


<210>  11
<211>  132
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ShK[2-35, K16] with N-terminal linker extension

<400>  11
ggaggaggag gatccggagg aggaggaagc agctgcatcg acaccatccc caagagccgc     60

tgcaccgcct tcaagtgcaa gcacagcatg aagtaccgcc tgagcttctg ccgcaagacc    120

tgcggcacct gc                                                        132


<210>  12
<211>  44
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ShK[2-35, Q16K] with N-terminal linker extension

<400>  12

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Cys Ile Asp Thr Ile 
1               5                   10                  15      


Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser Met Lys Tyr 
            20                  25                  30          


Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
        35                  40                  


<210>  13
<211>  28
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  13
ccgggtaaag gaggaggagg atccggag                                        28


<210>  14
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  14
catgcggccg ctcattagca ggtg                                            24


<210>  15
<211>  648
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Coding sequence of fragment of immunoglobulin Fc domain of human 
       IgG2

<400>  15
gcaccacctg tggcaggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc     60

atgatctccc ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca cgaagacccc    120

gaggtccagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagcca    180

cgggaggagc agttcaacag cacgttccgt gtggtcagcg tcctcaccgt tgtgcaccag    240

gactggctga acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccagccccc    300

atcgagaaaa ccatctccaa aaccaaaggg cagccccgag aaccacaggt gtacaccctg    360

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc    420

ttctacccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac    480

aagaccacac ctcccatgct ggactccgac ggctccttct tcctctacag caagctcacc    540

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct    600

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa                 648


<210>  16
<211>  216
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Fragment of immunoglobulin Fc domain of human IgG2

<400>  16

Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
            100                 105                 110         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        115                 120                 125             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    130                 135                 140                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
145                 150                 155                 160 


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                165                 170                 175     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            180                 185                 190         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        195                 200                 205             


Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215     


<210>  17
<211>  289
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH21SP-IgG2-Fc-L10-ShK(1-35, Q16K) Fusion polypeptide

<400>  17

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Arg Lys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            20                  25                  30          


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                245                 250                 255     


Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Gln Cys Lys 
            260                 265                 270         


His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr 
        275                 280                 285             


Cys 
    


<210>  18
<211>  289
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH21SP-IgG2-Fc-L10-ShK(1-35, Q16K) Fusion polypeptide

<400>  18

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Arg Lys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            20                  25                  30          


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                245                 250                 255     


Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys 
            260                 265                 270         


His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr 
        275                 280                 285             


Cys 
    


<210>  19
<211>  290
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH21SP-IgG2-Fc-L10-ShK(1-35, Q16K) Fusion polypeptide

<400>  19

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Arg Lys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            20                  25                  30          


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
                245                 250                 255     


Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Gln Cys 
            260                 265                 270         


Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly 
        275                 280                 285             


Thr Cys 
    290 


<210>  20
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  20
cataagcttc ccaccatgga atggagctgg                                      30


<210>  21
<211>  31
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  21
catggatcct catttacccg gagacaggga g                                    31


<210>  22
<211>  163
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Coding sequence ShK{1-35, Q16K) with an N-terminal linker

<400>  22
ggatccggag gaggaggaag ccgcagctgc atcgacacca tccccaagag ccgctgcacc     60

gccttcaagt gcaagcacag catgaagtac cgcctgagct tctgccgcaa gacctgcggc    120

acctgctaat gagcggccgc tcgaggccgg caaggccgga tcc                      163


<210>  23
<211>  42
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ShK{1-35, Q16K) with an N-terminal linker

<400>  23

Gly Ser Gly Gly Gly Gly Ser Arg Ser Cys Ile Asp Thr Ile Pro Lys 
1               5                   10                  15      


Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser Met Lys Tyr Arg Leu 
            20                  25                  30          


Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
        35                  40          


<210>  24
<211>  744
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Coding sequence - IgG2 fragment

<400>  24
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccgag     60

cgcaaagtcg agtgcccacc gtgcccagca ccacctgtgg caggaccgtc agtcttcctc    120

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacgtgcgtg    180

gtggtggacg tgagccacga agaccccgag gtccagttca actggtacgt ggacggcgtg    240

gaggtgcata atgccaagac aaagccacgg gaggagcagt tcaacagcac gttccgtgtg    300

gtcagcgtcc tcaccgttgt gcaccaggac tggctgaacg gcaaggagta caagtgcaag    360

gtctccaaca aaggcctccc agcccccatc gagaaaacca tctccaaaac caaagggcag    420

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag    480

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag    540

agcaatgggc agccggagaa caactacaag accacacctc ccatgctgga ctccgacggc    600

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc    660

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc    720

ctgtctccgg gtaaaggagg agga                                           744


<210>  25
<211>  248
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  IgG2 fragment

<400>  25

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Arg Lys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            20                  25                  30          


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys Gly Gly Gly 
                245             


<210>  26
<211>  290
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  IgG2 Fc-L10-ShK(1-35, Q16K) fusion protein

<400>  26

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Arg Lys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            20                  25                  30          


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
                245                 250                 255     


Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys 
            260                 265                 270         


Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly 
        275                 280                 285             


Thr Cys 
    290 


<210>  27
<211>  35
<212>  PRT
<213>  Stichodactyla helianthus


<220>
<221>  MISC_FEATURE
<223>  ShK

<400>  27

Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Gln 
1               5                   10                  15      


Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys 
            20                  25                  30          


Gly Thr Cys 
        35  


<210>  28
<211>  236
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 kappa LC

<400>  28

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


His Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  29
<211>  467
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 IgG2 HC

<400>  29

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  30
<211>  290
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  IgG2 Fc-L10-ShK(1-35)

<400>  30

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Arg Lys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            20                  25                  30          


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
                245                 250                 255     


Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Gln Cys 
            260                 265                 270         


Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly 
        275                 280                 285             


Thr Cys 
    290 


<210>  31
<211>  511
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 IgG2-ShK fusion

<400>  31

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Cys Ile 
465                 470                 475                 480 


Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Gln Cys Lys His Ser 
                485                 490                 495     


Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
            500                 505                 510     


<210>  32
<211>  511
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 IgG2-ShK[1-35, Q16K] fusion

<400>  32

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Cys Ile 
465                 470                 475                 480 


Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser 
                485                 490                 495     


Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
            500                 505                 510     


<210>  33
<211>  510
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 IgG2-ShK[2-35, Q16K] fusion

<400>  33

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Cys Ile Asp 
465                 470                 475                 480 


Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser Met 
                485                 490                 495     


Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
            500                 505                 510 


<210>  34
<211>  471
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 IgG1 HC

<400>  34

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  35
<211>  510
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 IgG1-loop-ShK

<400>  35

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Gly Gly 
    370                 375                 380                 


Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys 
385                 390                 395                 400 


Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys 
                405                 410                 415     


Gly Thr Cys Gly Gly Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            420                 425                 430         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        435                 440                 445             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    450                 455                 460                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
465                 470                 475                 480 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                485                 490                 495     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505                 510 


<210>  36
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Random primer with an extension adapter


<220>
<221>  misc_feature
<222>  (18)..(23)
<223>  Any deoxriboneucleotide

<400>  36
ggccggatag gcctccannn nnnt                                            24


<210>  37
<211>  45
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Forward primer

<400>  37
gtggttgaga ggtgccagat gtgacattgt gatgactcag tctcc                     45


<210>  38
<211>  41
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Reverse primer

<400>  38
aaccgtttaa acgcggccgc tcaacactct cccctgttga a                         41


<210>  39
<211>  43
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Optimized Kozak seqence

<400>  39
aagctcgagg tcgactagac caccatggac atgagggtcc ccg                       43


<210>  40
<211>  45
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  40
aagctcgagg tcgactagac caccatggac atgagggtgc ccgct                     45


<210>  41
<211>  25
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  41
tcatctggat gtcacatctg gcacc                                           25


<210>  42
<211>  25
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  42
ggtgccagat gtgacatcca gatga                                           25


<210>  43
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  43
cattctagac ccaccatgga catgagggtg                                      30


<210>  44
<211>  34
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  44
ggatcctcct cctccacccg gagacaggga gagg                                 34


<210>  45
<211>  1398
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6-VK1SP-IgG2 Heavy Chain coding sequence

<400>  45
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcc     60

agatgtcagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg    120

aaggtctcct gcaaggcttc tggatacacc ttcaccggct accacatgca ctgggtgcga    180

caggcccctg gacaagggct tgagtggatg ggatggatca accctaacag tggtggcaca    240

aactatgcac agaagtttca gggcagggtc accatgacca gggacacgtc catcagcaca    300

gcctacatgg agctgagcag gctgagatct gacgacacgg ccgtgtatta ctgtgcgaga    360

gatcgtggga gctactactg gttcgacccc tggggccagg gaaccctggt caccgtctcc    420

tcagcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc    480

gagagcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg    540

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc    600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag    660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag    720

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgtggcagg accgtcagtc    780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg    840

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaactg gtacgtggac    900

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc    960

cgtgtggtca gcgtcctcac cgttgtgcac caggactggc tgaacggcaa ggagtacaag   1020

tgcaaggtct ccaacaaagg cctcccagcc cccatcgaga aaaccatctc caaaaccaaa   1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag   1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag   1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc   1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg   1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc   1380

ctctccctgt ctccgggt                                                 1398


<210>  46
<211>  466
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6-VK1SP-IgG2 Heavy Chain

<400>  46

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly 
465     


<210>  47
<211>  34
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  47
tccctgtctc cgggtggagg aggaggatcc ggag                                 34


<210>  48
<211>  511
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  IgG2-HC-L10-ShK[1-35] fusion polypeptide

<400>  48

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Cys Ile 
465                 470                 475                 480 


Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Gln Cys Lys His Ser 
                485                 490                 495     


Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
            500                 505                 510     


<210>  49
<211>  511
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  IgG2-HC-L10-ShK[1-35, Q16K] fusion polypeptide

<400>  49

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Cys Ile 
465                 470                 475                 480 


Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser 
                485                 490                 495     


Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
            500                 505                 510     


<210>  50
<211>  1407
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Coding sequence

<400>  50
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcc     60

agatgtcagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg    120

aaggtctcct gcaaggcttc tggatacacc ttcaccggct accacatgca ctgggtgcga    180

caggcccctg gacaagggct tgagtggatg ggatggatca accctaacag tggtggcaca    240

aactatgcac agaagtttca gggcagggtc accatgacca gggacacgtc catcagcaca    300

gcctacatgg agctgagcag gctgagatct gacgacacgg ccgtgtatta ctgtgcgaga    360

gatcgtggga gctactactg gttcgacccc tggggccagg gaaccctggt caccgtctcc    420

tcagcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc    480

gagagcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg    540

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc    600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag    660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag    720

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgtggcagg accgtcagtc    780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg    840

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaactg gtacgtggac    900

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc    960

cgtgtggtca gcgtcctcac cgttgtgcac caggactggc tgaacggcaa ggagtacaag   1020

tgcaaggtct ccaacaaagg cctcccagcc cccatcgaga aaaccatctc caaaaccaaa   1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag   1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag   1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc   1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg   1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc   1380

ctctccctgt ctccgggtgg aggagga                                       1407


<210>  51
<211>  469
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polypeptide sequence

<400>  51

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly 
465                 


<210>  52
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Coding sequence

<400>  52
ggatccggag gaggaggaag cagctgcatc gacaccatcc ccaagagccg ctgcaccgcc     60

ttcaagtgca agcacagcat gaagtaccgc ctgagcttct gccgcaagac ctgcggcacc    120

tgctaatga                                                            129


<210>  53
<211>  41
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polypeptide sequence

<400>  53

Gly Ser Gly Gly Gly Gly Ser Ser Cys Ile Asp Thr Ile Pro Lys Ser 
1               5                   10                  15      


Arg Cys Thr Ala Phe Lys Cys Lys His Ser Met Lys Tyr Arg Leu Ser 
            20                  25                  30          


Phe Cys Arg Lys Thr Cys Gly Thr Cys 
        35                  40      


<210>  54
<211>  510
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  IgG2-HC-L10-ShK[2-35] fusion polypeptide

<400>  54

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Cys Ile Asp 
465                 470                 475                 480 


Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser Met 
                485                 490                 495     


Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
            500                 505                 510 


<210>  55
<211>  127
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  HINDIII Site

<400>  55
tgcagaagct tctagaccac catggaatgg agctgggtct ttctcttctt cctgtcagta     60

acgactggtg tccactcccg cagctgcatc gacaccatcc ccaagagccg ctgcaccgcc    120

ttccagt                                                              127


<210>  56
<211>  115
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  BAMHI Site

<400>  56
ctccggatcc tcctcctccg caggtgccgc aggtcttgcg gcagaagctc aggcggtact     60

tcatgctgtg cttgcactgg aaggcggtgc agcggctctt ggggatggtg tcgat         115


<210>  57
<211>  38
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  BAMHI Site

<400>  57
gtaggatccg gaggaggagg aagcgacaaa actcacac                             38


<210>  58
<211>  35
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (4)..(11)
<223>  NOTI Site

<400>  58
cgagcggccg cttactattt acccggagac aggga                                35


<210>  59
<211>  879
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH21 SP-ShK(1-35)-L10-IgG1 Fc coding sequence

<400>  59
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactcccgc     60

agctgcatcg acaccatccc caagagccgc tgcaccgcct tccagtgcaa gcacagcatg    120

aagtaccgcc tgagcttctg ccgcaagacc tgcggcacct gcggaggagg aggatccgga    180

ggaggaggaa gcgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg    240

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc    300

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac    360

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac    420

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc    480

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc    540

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat    600

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac    660

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc    720

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg    780

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac    840

acgcagaaga gcctctccct gtctccgggt aaatagtaa                           879


<210>  60
<211>  291
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH21 SP-ShK(1-35)-L10-IgG1 Fc

<400>  60

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr 
            20                  25                  30          


Ala Phe Gln Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg 
        35                  40                  45              


Lys Thr Cys Gly Thr Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60                  


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
65                  70                  75                  80  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                85                  90                  95      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            100                 105                 110         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        115                 120                 125             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    130                 135                 140                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
145                 150                 155                 160 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                165                 170                 175     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            180                 185                 190         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        195                 200                 205             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    210                 215                 220                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
225                 230                 235                 240 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                245                 250                 255     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            260                 265                 270         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        275                 280                 285             


Pro Gly Lys 
    290     


<210>  61
<211>  291
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH21 SP-ShK(1-35, Q16K)-L10-IgG1 Fc

<400>  61

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr 
            20                  25                  30          


Ala Phe Lys Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg 
        35                  40                  45              


Lys Thr Cys Gly Thr Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60                  


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
65                  70                  75                  80  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                85                  90                  95      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            100                 105                 110         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        115                 120                 125             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    130                 135                 140                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
145                 150                 155                 160 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                165                 170                 175     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            180                 185                 190         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        195                 200                 205             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    210                 215                 220                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
225                 230                 235                 240 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                245                 250                 255     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            260                 265                 270         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        275                 280                 285             


Pro Gly Lys 
    290     


<210>  62
<211>  23
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  62
cattctagac caccatggaa tgg                                             23


<210>  63
<211>  29
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  63
cagctgcacc tggcttcctc ctcctccgg                                       29


<210>  64
<211>  192
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH21 SP-ShK(1-35, Q16K)-L10 coding sequence

<400>  64
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactcccgc     60

agctgcatcg acaccatccc caagagccgc tgcaccgcct tcaagtgcaa gcacagcatg    120

aagtaccgcc tgagcttctg ccgcaagacc tgcggcacct gcggaggagg aggatccgga    180

ggaggaggaa gc                                                        192


<210>  65
<211>  64
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH21 SP-ShK(1-35, Q16K)-L10

<400>  65

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr 
            20                  25                  30          


Ala Phe Lys Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg 
        35                  40                  45              


Lys Thr Cys Gly Thr Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60                  


<210>  66
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  66
ggaggaggaa gccaggtgca gctggtgcag                                      30


<210>  67
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  67
catgcggccg ctcatttacc c                                               21


<210>  68
<211>  1338
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6-HC coding sequence

<400>  68
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggata caccttcacc ggctaccaca tgcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat    180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac    240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagatcgt    300

gggagctact actggttcga cccctggggc cagggaaccc tggtcaccgt ctcctcagcc    360

tccaccaagg gcccatcggt cttccccctg gcgccctgct ccaggagcac ctccgagagc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ctctgaccag cggcgtgcac accttcccag ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca acttcggcac ccagacctac    600

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagacagt tgagcgcaaa    660

tgttgtgtcg agtgcccacc gtgcccagca ccacctgtgg caggaccgtc agtcttcctc    720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacgtgcgtg    780

gtggtggacg tgagccacga agaccccgag gtccagttca actggtacgt ggacggcgtg    840

gaggtgcata atgccaagac aaagccacgg gaggagcagt tcaacagcac gttccgtgtg    900

gtcagcgtcc tcaccgttgt gcaccaggac tggctgaacg gcaaggagta caagtgcaag    960

gtctccaaca aaggcctccc agcccccatc gagaaaacca tctccaaaac caaagggcag   1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag   1080

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag   1140

agcaatgggc agccggagaa caactacaag accacacctc ccatgctgga ctccgacggc   1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc   1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc   1320

ctgtctccgg gtaaatga                                                 1338


<210>  69
<211>  445
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6-HC polypeptide sequence

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  70
<211>  509
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH21 SP-ShK[1-35, Q16K]-L10-aKLH120.6-HC fusion polypeptide

<400>  70

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr 
            20                  25                  30          


Ala Phe Lys Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg 
        35                  40                  45              


Lys Thr Cys Gly Thr Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60                  


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
65                  70                  75                  80  


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
                85                  90                  95      


His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
            100                 105                 110         


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
        115                 120                 125             


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
    130                 135                 140                 


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
145                 150                 155                 160 


Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe Asp Pro Trp Gly Gln Gly 
                165                 170                 175     


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
            180                 185                 190         


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
        195                 200                 205             


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
    210                 215                 220                 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
225                 230                 235                 240 


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
                245                 250                 255     


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
            260                 265                 270         


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
        275                 280                 285             


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
    290                 295                 300                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
305                 310                 315                 320 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
                325                 330                 335     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            340                 345                 350         


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
        355                 360                 365             


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    370                 375                 380                 


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
385                 390                 395                 400 


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                405                 410                 415     


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            420                 425                 430         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        435                 440                 445             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
    450                 455                 460                 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
465                 470                 475                 480 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                485                 490                 495     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505                 


<210>  71
<211>  29
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  71
catctggatg tcgcttcctc ctcctccgg                                       29


<210>  72
<211>  32
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  72
ggaggaggaa gcgacatcca gatgacccag tc                                   32


<210>  73
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  73
catctcgagc ggccgctcaa c                                               21


<210>  74
<211>  837
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH21 SP-ShK[1-35, Q16K]-L10-aKLH120.6 Light Chain coding sequence

<400>  74
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactcccgc     60

agctgcatcg acaccatccc caagagccgc tgcaccgcct tcaagtgcaa gcacagcatg    120

aagtaccgcc tgagcttctg ccgcaagacc tgcggcacct gcggaggagg aggatccgga    180

ggaggaggaa gcgacatcca gatgacccag tctccatcct ccctgtctgc atctgtagga    240

gacagagtca ccatcacttg ccgggcaagt cagggcatta gaaatgattt aggctggtat    300

cagcagaaac cagggaaagc ccctaaacgc ctgatctatg ctgcatccag tttgcaaagt    360

ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct cacaatcagc    420

agcctgcagc ctgaagattt tgcaacttat tactgtctac agcataatag ttacccgctc    480

actttcggcg gagggaccaa ggtggagatc aaacgaactg tggctgcacc atctgtcttc    540

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg    600

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg    660

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc    720

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc    780

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttga       837


<210>  75
<211>  278
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH21 SP-ShK[1-35, Q16K]-L10-aKLH120.6 Light Chain

<400>  75

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr 
            20                  25                  30          


Ala Phe Lys Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg 
        35                  40                  45              


Lys Thr Cys Gly Thr Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60                  


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
65                  70                  75                  80  


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
                85                  90                  95      


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
            100                 105                 110         


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        115                 120                 125             


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    130                 135                 140                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu 
145                 150                 155                 160 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
                165                 170                 175     


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
            180                 185                 190         


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
        195                 200                 205             


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
    210                 215                 220                 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
225                 230                 235                 240 


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
                245                 250                 255     


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
            260                 265                 270         


Phe Asn Arg Gly Glu Cys 
        275             


<210>  76
<211>  35
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ShK[1-35, Q16K] polypeptide

<400>  76

Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys 
1               5                   10                  15      


Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys 
            20                  25                  30          


Gly Thr Cys 
        35  


<210>  77
<211>  465
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  anti-DNP 3A4 (W101F) IgG2 Heavy Chain

<400>  77

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Phe Asn Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly 
465 


<210>  78
<211>  1038
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Coding sequence - IgG2 fragment

<400>  78
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtcagg tgcagctggt ggagtctggg ggaggcgtgg tccagcctgg gaggtccctg    120

agactctcct gtgcagcgtc tggattcacc ttcagtagct atggcatgca ctgggtccgc    180

caggctccag gcaaggggct ggagtgggtg gcagttatat ggtatgatgg aagtaataaa    240

tactatgcag actccgtgaa gggccgattc actatctcca gagacaattc caagaacacg    300

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgagg    360

tataacttca actacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctctagt    420

gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag    480

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    540

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca    600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc    660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc    720

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc    780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc    840

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc    900

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt    960

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc   1020

aaggtctcca acaaaggc                                                 1038


<210>  79
<211>  346
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  IgG2 fragment

<400>  79

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Phe Asn Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            340                 345     


<210>  80
<211>  501
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  truncated IgG2 Fc-L10-ShK(1-35, Q16K) coding sequence

<400>  80
ctcccagccc ccatcgagaa aaccatctcc aaaaccaaag ggcagccccg agaaccacag     60

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc    120

ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcaa tgggcagccg    180

gagaacaact acaagaccac acctcccatg ctggactccg acggctcctt cttcctctac    240

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg    300

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa    360

ggaggaggag gatccggagg aggaggaagc cgcagctgca tcgacaccat ccccaagagc    420

cgctgcaccg ccttcaagtg caagcacagc atgaagtacc gcctgagctt ctgccgcaag    480

acctgcggca cctgctaatg a                                              501


<210>  81
<211>  165
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  truncated IgG2 Fc-L10-ShK(1-35, Q16K) amino acid sequence

<400>  81

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
1               5                   10                  15      


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            20                  25                  30          


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        35                  40                  45              


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    50                  55                  60                  


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
65                  70                  75                  80  


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                85                  90                  95      


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            100                 105                 110         


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala 
    130                 135                 140                 


Phe Lys Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys 
145                 150                 155                 160 


Thr Cys Gly Thr Cys 
                165 


<210>  82
<211>  510
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3A4 (W101F) IgG2 HC-L10-ShK[1-35, Q16K] fusion protein

<400>  82

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Phe Asn Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Cys Ile Asp 
465                 470                 475                 480 


Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser Met 
                485                 490                 495     


Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
            500                 505                 510 


<210>  83
<211>  37
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Forward primer

<400>  83
ttttttttgc gcgctgtgac atccagatga cccagtc                              37


<210>  84

<400>  84
000

<210>  85
<211>  236
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  anti-DNP 3A4 Antibody Light Chain

<400>  85

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Ser Arg Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ala Asn Ser Phe Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  86
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IgG2 heavy chain (HC) constant domain

<400>  86

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  87
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hIgG1z heavy chain (HC) constant domain

<400>  87

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  88
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hIgG1za heavy chain (HC) constant domain

<400>  88

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  89
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hIgG1f heavy chain (HC) constant domain

<400>  89

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  90
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hIgG1fa heavy chain (HC) constant domain

<400>  90

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  91
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CL-1 human immunoglobulin light chain (LC) constant region

<400>  91

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  92
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CL-2 human immunoglobulin light chain (LC) constant region

<400>  92

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  93
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CL-3 human immunoglobulin light chain (LC) constant region

<400>  93

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  94
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CL-7 human immunoglobulin light chain (LC) constant region

<400>  94

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  95
<211>  19
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH21 SP

<400>  95

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  96
<211>  448
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Anti-KLH heavy chain (IgG1)

<400>  96

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  97
<211>  241
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Anti-KLH light chain-AMP5

<400>  97

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Gly Gln Gly Cys Ser Ser 
    210                 215                 220                 


Gly Gly Pro Thr Leu Arg Glu Trp Gln Gln Cys Arg Arg Ala Gln His 
225                 230                 235                 240 


Ser 
    


<210>  98
<211>  471
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  AMP5-Anti-KLH HC (IgG2)

<400>  98

Gln Gly Cys Ser Ser Gly Gly Pro Thr Leu Arg Glu Trp Gln Gln Cys 
1               5                   10                  15      


Arg Arg Ala Gln His Ser Gly Gly Gly Gly Gly Gln Val Gln Leu Val 
            20                  25                  30          


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
        35                  40                  45              


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr His Met His Trp Val 
    50                  55                  60                  


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro 
65                  70                  75                  80  


Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
                85                  90                  95      


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg 
            100                 105                 110         


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly 
        115                 120                 125             


Ser Tyr Tyr Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
145                 150                 155                 160 


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly 
465                 470     


<210>  99
<211>  214
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Anti-KLH LC

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  100
<211>  471
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Anti-KLH HC-AMP5 (IgG2)

<400>  100

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        435                 440                 445             


Gly Gln Gly Cys Ser Ser Gly Gly Pro Thr Leu Arg Glu Trp Gln Gln 
    450                 455                 460                 


Cys Arg Arg Ala Gln His Ser 
465                 470     


<210>  101
<211>  241
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  AMP5-Anti-KLH LC

<400>  101

Gln Gly Cys Ser Ser Gly Gly Pro Thr Leu Arg Glu Trp Gln Gln Cys 
1               5                   10                  15      


Arg Arg Ala Gln His Ser Gly Gly Gly Gly Gly Asp Ile Gln Met Thr 
            20                  25                  30          


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        35                  40                  45              


Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser 
65                  70                  75                  80  


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys 
    


<210>  102
<211>  66
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VK-1 SP signal peptide coding sequence

<400>  102
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgt                                                                66


<210>  103
<211>  22
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VK-1 SP signal peptide

<400>  103

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  104
<211>  708
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3A1 LC sequence


<220>
<221>  CDS
<222>  (1)..(708)

<400>  104
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt gac atc cag atg acc cag tct cca tct tcc       96
Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser         
            20                  25                  30                  

gtg tct gca tct gta ggt gac aga gtc acc atc act tgt cgg gcg agt      144
Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser         
        35                  40                  45                      

cag ggt att agc aac tgg tta gcc tgg tat cag cgg aaa cca ggg aaa      192
Gln Gly Ile Ser Asn Trp Leu Ala Trp Tyr Gln Arg Lys Pro Gly Lys         
    50                  55                  60                          

gcc cct aag ctc ctg atc tat gct gca tcc agt ttg caa agt ggg gtc      240
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val         
65                  70                  75                  80          

cca tca agg ttc agc ggc agt gga tct ggg aca gat ttc act ctc acc      288
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr         
                85                  90                  95              

atc agc agc ctg cag cct gaa gat ttt gca gct tac tat tgt caa cag      336
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln         
            100                 105                 110                 

gct agc agt ttc ccg tgg acg ttc ggc caa ggg acc agg gtg gaa atc      384
Ala Ser Ser Phe Pro Trp Thr Phe Gly Gln Gly Thr Arg Val Glu Ile         
        115                 120                 125                     

aaa cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat      432
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp         
    130                 135                 140                         

gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac      480
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn         
145                 150                 155                 160         

ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc      528
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu         
                165                 170                 175             

caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac      576
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp         
            180                 185                 190                 

agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac      624
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr         
        195                 200                 205                     

gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc      672
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser         
    210                 215                 220                         

tcg ccc gtc aca aag agc ttc aac agg gga gag tgt                      708
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                         
225                 230                 235                             


<210>  105
<211>  236
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  105

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Ser Asn Trp Leu Ala Trp Tyr Gln Arg Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ala Ser Ser Phe Pro Trp Thr Phe Gly Gln Gly Thr Arg Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  106
<211>  1410
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3A1 HC sequence


<220>
<221>  CDS
<222>  (1)..(1410)

<400>  106
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt cag gtg cag ctg cag gag tcg ggc cca gga       96
Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly         
            20                  25                  30                  

ctg gtg aag cct tcg gag acc ctg tcc ctc acc tgc act gtc tct ggt      144
Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly         
        35                  40                  45                      

ggc tcc atc agt cat tac tac tgg agc tgg atc cgg cag ccc cca ggg      192
Gly Ser Ile Ser His Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly         
    50                  55                  60                          

aag gga ctg ggg tgg att ggg tat atc tat tac agt ggg agc acc aac      240
Lys Gly Leu Gly Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn         
65                  70                  75                  80          

tac aac ccc tcc ctc aag agt cga gtc acc ata tca gta gac acg tcc      288
Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser         
                85                  90                  95              

aag aac cag ttc tcc ctg aag ctg acc tct gtg acc gct gcg gac acg      336
Lys Asn Gln Phe Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr         
            100                 105                 110                 

gcc gtg tat tac tgt gcg agg gcc cgg gga gat ggc tac aat tac cct      384
Ala Val Tyr Tyr Cys Ala Arg Ala Arg Gly Asp Gly Tyr Asn Tyr Pro         
        115                 120                 125                     

gat gct ttt gat atc tgg ggc caa ggg aca atg gtc acc gtc tct agt      432
Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser         
    130                 135                 140                         

gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg      480
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg         
145                 150                 155                 160         

agc acc tcc gag agc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac      528
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr         
                165                 170                 175             

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gct ctg acc agc      576
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser         
            180                 185                 190                 

ggc gtg cac acc ttc cca gct gtc cta cag tcc tca gga ctc tac tcc      624
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser         
        195                 200                 205                     

ctc agc agc gtg gtg acc gtg ccc tcc agc aac ttc ggc acc cag acc      672
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr         
    210                 215                 220                         

tac acc tgc aac gta gat cac aag ccc agc aac acc aag gtg gac aag      720
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys         
225                 230                 235                 240         

aca gtt gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc cca gca cca      768
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro         
                245                 250                 255             

cct gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac      816
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp         
            260                 265                 270                 

acc ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac      864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp         
        275                 280                 285                     

gtg agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc      912
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly         
    290                 295                 300                         

gtg gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac      960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn         
305                 310                 315                 320         

agc acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg     1008
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp         
                325                 330                 335             

ctg aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca     1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro         
            340                 345                 350                 

gcc ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa     1104
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu         
        355                 360                 365                     

cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac     1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn         
    370                 375                 380                         

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc     1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile         
385                 390                 395                 400         

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc     1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr         
                405                 410                 415             

aca cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag     1296
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys         
            420                 425                 430                 

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc     1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys         
        435                 440                 445                     

tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc     1392
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu         
    450                 455                 460                         

tcc ctg tct ccg ggt aaa                                             1410
Ser Leu Ser Pro Gly Lys                                                 
465                 470                                                 


<210>  107
<211>  470
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  107

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser His Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Gly Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ala Arg Gly Asp Gly Tyr Asn Tyr Pro 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
305                 310                 315                 320 


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  108
<211>  708
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3A4 LC sequence


<220>
<221>  CDS
<222>  (1)..(708)

<400>  108
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt gac atc cag atg acc cag tct cca tct tcc       96
Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser         
            20                  25                  30                  

gtg tct gca tct gta gga gac aga gtc acc atc act tgt cgg gcg agt      144
Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser         
        35                  40                  45                      

cag ggt att agt agg agg tta gcc tgg tat cag cag aaa cca ggg aaa      192
Gln Gly Ile Ser Arg Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys         
    50                  55                  60                          

gcc cct aag ctc ctg atc tat gct gca tcc agt ttg caa agt ggg gtc      240
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val         
65                  70                  75                  80          

cca tca agg ttc agc ggc agt gga tct ggg aca gat ttc act ctc acc      288
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr         
                85                  90                  95              

atc agc agc ctg cag cct gaa gat ttt gca act tac tat tgt caa cag      336
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln         
            100                 105                 110                 

gct aac agt ttc cct ttc act ttc ggc cct ggg acc aaa gtg gat atc      384
Ala Asn Ser Phe Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile         
        115                 120                 125                     

aaa cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat      432
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp         
    130                 135                 140                         

gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac      480
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn         
145                 150                 155                 160         

ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc      528
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu         
                165                 170                 175             

caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac      576
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp         
            180                 185                 190                 

agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac      624
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr         
        195                 200                 205                     

gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc      672
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser         
    210                 215                 220                         

tcg ccc gtc aca aag agc ttc aac agg gga gag tgt                      708
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                         
225                 230                 235                             


<210>  109
<211>  236
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  109

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Ser Arg Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ala Asn Ser Phe Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  110
<211>  1398
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3A4. IgG2  HC sequence


<220>
<221>  CDS
<222>  (1)..(1398)

<400>  110
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt cag gtg cag ctg gtg gag tct ggg gga ggc       96
Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly         
            20                  25                  30                  

gtg gtc cag cct ggg agg tcc ctg aga ctc tcc tgt gca gcg tct gga      144
Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly         
        35                  40                  45                      

ttc acc ttc agt agc tat ggc atg cac tgg gtc cgc cag gct cca ggc      192
Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly         
    50                  55                  60                          

aag ggg ctg gag tgg gtg gca gtt ata tgg tat gat gga agt aat aaa      240
Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys         
65                  70                  75                  80          

tac tat gca gac tcc gtg aag ggc cga ttc act atc tcc aga gac aat      288
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn         
                85                  90                  95              

tcc aag aac acg ctg tat ctg caa atg aac agc ctg aga gcc gag gac      336
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp         
            100                 105                 110                 

acg gct gtg tat tac tgt gcg agg tat aac tgg aac tac ggt atg gac      384
Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Trp Asn Tyr Gly Met Asp         
        115                 120                 125                     

gtc tgg ggc caa ggg acc acg gtc acc gtc tct agt gcc tcc acc aag      432
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys         
    130                 135                 140                         

ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg agc acc tcc gag      480
Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu         
145                 150                 155                 160         

agc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg      528
Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro         
                165                 170                 175             

gtg acg gtg tcg tgg aac tca ggc gct ctg acc agc ggc gtg cac acc      576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr         
            180                 185                 190                 

ttc cca gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg      624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val         
        195                 200                 205                     

gtg acc gtg ccc tcc agc aac ttc ggc acc cag acc tac acc tgc aac      672
Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn         
    210                 215                 220                         

gta gat cac aag ccc agc aac acc aag gtg gac aag aca gtt gag cgc      720
Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg         
225                 230                 235                 240         

aaa tgt tgt gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga      768
Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly         
                245                 250                 255             

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc      816
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile         
            260                 265                 270                 

tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa      864
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu         
        275                 280                 285                     

gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat      912
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His         
    290                 295                 300                         

aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt      960
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg         
305                 310                 315                 320         

gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag     1008
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys         
                325                 330                 335             

gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag     1056
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu         
            340                 345                 350                 

aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac     1104
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr         
        355                 360                 365                     

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg     1152
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu         
    370                 375                 380                         

acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc gcc gtg gag tgg     1200
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp         
385                 390                 395                 400         

gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg     1248
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met         
                405                 410                 415             

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac     1296
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp         
            420                 425                 430                 

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat     1344
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His         
        435                 440                 445                     

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg     1392
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro         
    450                 455                 460                         

ggt aaa                                                             1398
Gly Lys                                                                 
465                                                                     


<210>  111
<211>  466
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  111

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Trp Asn Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  112
<211>  1398
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP  3A4 W101F IgG2 HC sequence


<220>
<221>  CDS
<222>  (1)..(1398)

<400>  112
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt cag gtg cag ctg gtg gag tct ggg gga ggc       96
Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly         
            20                  25                  30                  

gtg gtc cag cct ggg agg tcc ctg aga ctc tcc tgt gca gcg tct gga      144
Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly         
        35                  40                  45                      

ttc acc ttc agt agc tat ggc atg cac tgg gtc cgc cag gct cca ggc      192
Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly         
    50                  55                  60                          

aag ggg ctg gag tgg gtg gca gtt ata tgg tat gat gga agt aat aaa      240
Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys         
65                  70                  75                  80          

tac tat gca gac tcc gtg aag ggc cga ttc act atc tcc aga gac aat      288
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn         
                85                  90                  95              

tcc aag aac acg ctg tat ctg caa atg aac agc ctg aga gcc gag gac      336
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp         
            100                 105                 110                 

acg gct gtg tat tac tgt gcg agg tat aac ttc aac tac ggt atg gac      384
Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Phe Asn Tyr Gly Met Asp         
        115                 120                 125                     

gtc tgg ggc caa ggg acc acg gtc acc gtc tct agt gcc tcc acc aag      432
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys         
    130                 135                 140                         

ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg agc acc tcc gag      480
Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu         
145                 150                 155                 160         

agc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg      528
Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro         
                165                 170                 175             

gtg acg gtg tcg tgg aac tca ggc gct ctg acc agc ggc gtg cac acc      576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr         
            180                 185                 190                 

ttc cca gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg      624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val         
        195                 200                 205                     

gtg acc gtg ccc tcc agc aac ttc ggc acc cag acc tac acc tgc aac      672
Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn         
    210                 215                 220                         

gta gat cac aag ccc agc aac acc aag gtg gac aag aca gtt gag cgc      720
Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg         
225                 230                 235                 240         

aaa tgt tgt gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga      768
Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly         
                245                 250                 255             

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc      816
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile         
            260                 265                 270                 

tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa      864
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu         
        275                 280                 285                     

gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat      912
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His         
    290                 295                 300                         

aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt      960
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg         
305                 310                 315                 320         

gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag     1008
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys         
                325                 330                 335             

gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag     1056
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu         
            340                 345                 350                 

aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac     1104
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr         
        355                 360                 365                     

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg     1152
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu         
    370                 375                 380                         

acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc gcc gtg gag tgg     1200
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp         
385                 390                 395                 400         

gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg     1248
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met         
                405                 410                 415             

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac     1296
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp         
            420                 425                 430                 

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat     1344
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His         
        435                 440                 445                     

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg     1392
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro         
    450                 455                 460                         

ggt aaa                                                             1398
Gly Lys                                                                 
465                                                                     


<210>  113
<211>  466
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  113

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Phe Asn Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  114
<211>  1398
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3A4 W101Y IgG2 HC sequence


<220>
<221>  CDS
<222>  (1)..(1398)

<400>  114
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt cag gtg cag ctg gtg gag tct ggg gga ggc       96
Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly         
            20                  25                  30                  

gtg gtc cag cct ggg agg tcc ctg aga ctc tcc tgt gca gcg tct gga      144
Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly         
        35                  40                  45                      

ttc acc ttc agt agc tat ggc atg cac tgg gtc cgc cag gct cca ggc      192
Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly         
    50                  55                  60                          

aag ggg ctg gag tgg gtg gca gtt ata tgg tat gat gga agt aat aaa      240
Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys         
65                  70                  75                  80          

tac tat gca gac tcc gtg aag ggc cga ttc act atc tcc aga gac aat      288
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn         
                85                  90                  95              

tcc aag aac acg ctg tat ctg caa atg aac agc ctg aga gcc gag gac      336
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp         
            100                 105                 110                 

acg gct gtg tat tac tgt gcg agg tat aac tac aac tac ggt atg gac      384
Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Tyr Asn Tyr Gly Met Asp         
        115                 120                 125                     

gtc tgg ggc caa ggg acc acg gtc acc gtc tct agt gcc tcc acc aag      432
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys         
    130                 135                 140                         

ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg agc acc tcc gag      480
Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu         
145                 150                 155                 160         

agc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg      528
Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro         
                165                 170                 175             

gtg acg gtg tcg tgg aac tca ggc gct ctg acc agc ggc gtg cac acc      576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr         
            180                 185                 190                 

ttc cca gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg      624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val         
        195                 200                 205                     

gtg acc gtg ccc tcc agc aac ttc ggc acc cag acc tac acc tgc aac      672
Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn         
    210                 215                 220                         

gta gat cac aag ccc agc aac acc aag gtg gac aag aca gtt gag cgc      720
Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg         
225                 230                 235                 240         

aaa tgt tgt gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga      768
Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly         
                245                 250                 255             

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc      816
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile         
            260                 265                 270                 

tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa      864
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu         
        275                 280                 285                     

gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat      912
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His         
    290                 295                 300                         

aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt      960
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg         
305                 310                 315                 320         

gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag     1008
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys         
                325                 330                 335             

gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag     1056
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu         
            340                 345                 350                 

aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac     1104
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr         
        355                 360                 365                     

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg     1152
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu         
    370                 375                 380                         

acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc gcc gtg gag tgg     1200
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp         
385                 390                 395                 400         

gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg     1248
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met         
                405                 410                 415             

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac     1296
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp         
            420                 425                 430                 

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat     1344
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His         
        435                 440                 445                     

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg     1392
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro         
    450                 455                 460                         

ggt aaa                                                             1398
Gly Lys                                                                 
465                                                                     


<210>  115
<211>  466
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  115

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Tyr Asn Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  116
<211>  1398
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3A4-FSS IgG2 HC sequence


<220>
<221>  CDS
<222>  (1)..(1398)

<400>  116
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt cag gtg cag ctg gtg gag tct ggg gga ggc       96
Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly         
            20                  25                  30                  

gtg gtc cag cct ggg agg tcc ctg aga ctc tcc tgt gca gcg tct gga      144
Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly         
        35                  40                  45                      

ttc acc ttc agt agc tat ggc atg cac tgg gtc cgc cag gct cca ggc      192
Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly         
    50                  55                  60                          

aag ggg ctg gag tgg gtg gca gtt ata tgg tat gat gga agt aat aaa      240
Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys         
65                  70                  75                  80          

tac tat gca gac tcc gtg aag ggc cga ttc act atc tcc aga gac aat      288
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn         
                85                  90                  95              

tcc aag aac acg ctg tat ctg caa atg aac agc ctg aga gcc gag gac      336
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp         
            100                 105                 110                 

acg gct gtg tat tac tgt gcg agg tat aac ttc aac tac ggt atg gac      384
Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Phe Asn Tyr Gly Met Asp         
        115                 120                 125                     

gtc tgg ggc caa ggg acc acg gtc acc gtc tct agt gcc tcc acc aag      432
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys         
    130                 135                 140                         

ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg agc acc tcc gag      480
Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu         
145                 150                 155                 160         

agc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg      528
Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro         
                165                 170                 175             

gtg acg gtg tcg tgg aac tca ggc gct ctg acc agc ggc gtg cac acc      576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr         
            180                 185                 190                 

ttc cca gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg      624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val         
        195                 200                 205                     

gtg acc gtg ccc tcc agc aac ttc ggc acc cag acc tac acc tgc aac      672
Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn         
    210                 215                 220                         

gta gat cac aag ccc agc aac acc aag gtg gac aag aca gtt gag cgc      720
Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg         
225                 230                 235                 240         

aaa tct tct gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga      768
Lys Ser Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly         
                245                 250                 255             

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc      816
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile         
            260                 265                 270                 

tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa      864
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu         
        275                 280                 285                     

gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat      912
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His         
    290                 295                 300                         

aat gcc aag aca aaa cca cgg gag gag cag ttc aac agc acg ttc cgt      960
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg         
305                 310                 315                 320         

gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag     1008
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys         
                325                 330                 335             

gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag     1056
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu         
            340                 345                 350                 

aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac     1104
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr         
        355                 360                 365                     

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg     1152
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu         
    370                 375                 380                         

acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc gcc gtg gag tgg     1200
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp         
385                 390                 395                 400         

gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg     1248
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met         
                405                 410                 415             

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac     1296
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp         
            420                 425                 430                 

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat     1344
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His         
        435                 440                 445                     

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg     1392
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro         
    450                 455                 460                         

ggt aaa                                                             1398
Gly Lys                                                                 
465                                                                     


<210>  117
<211>  466
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  117

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Phe Asn Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Ser Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  118
<211>  1398
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3A4-YSS IgG2 HC sequence


<220>
<221>  CDS
<222>  (1)..(1398)

<400>  118
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt cag gtg cag ctg gtg gag tct ggg gga ggc       96
Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly         
            20                  25                  30                  

gtg gtc cag cct ggg agg tcc ctg aga ctc tcc tgt gca gcg tct gga      144
Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly         
        35                  40                  45                      

ttc acc ttc agt agc tat ggc atg cac tgg gtc cgc cag gct cca ggc      192
Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly         
    50                  55                  60                          

aag ggg ctg gag tgg gtg gca gtt ata tgg tat gat gga agt aat aaa      240
Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys         
65                  70                  75                  80          

tac tat gca gac tcc gtg aag ggc cga ttc act atc tcc aga gac aat      288
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn         
                85                  90                  95              

tcc aag aac acg ctg tat ctg caa atg aac agc ctg aga gcc gag gac      336
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp         
            100                 105                 110                 

acg gct gtg tat tac tgt gcg agg tat aac tac aac tac ggt atg gac      384
Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Tyr Asn Tyr Gly Met Asp         
        115                 120                 125                     

gtc tgg ggc caa ggg acc acg gtc acc gtc tct agt gcc tcc acc aag      432
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys         
    130                 135                 140                         

ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg agc acc tcc gag      480
Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu         
145                 150                 155                 160         

agc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg      528
Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro         
                165                 170                 175             

gtg acg gtg tcg tgg aac tca ggc gct ctg acc agc ggc gtg cac acc      576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr         
            180                 185                 190                 

ttc cca gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg      624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val         
        195                 200                 205                     

gtg acc gtg ccc tcc agc aac ttc ggc acc cag acc tac acc tgc aac      672
Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn         
    210                 215                 220                         

gta gat cac aag ccc agc aac acc aag gtg gac aag aca gtt gag cgc      720
Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg         
225                 230                 235                 240         

aaa tct tct gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga      768
Lys Ser Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly         
                245                 250                 255             

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc      816
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile         
            260                 265                 270                 

tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa      864
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu         
        275                 280                 285                     

gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat      912
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His         
    290                 295                 300                         

aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt      960
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg         
305                 310                 315                 320         

gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag     1008
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys         
                325                 330                 335             

gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag     1056
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu         
            340                 345                 350                 

aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac     1104
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr         
        355                 360                 365                     

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg     1152
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu         
    370                 375                 380                         

acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc gcc gtg gag tgg     1200
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp         
385                 390                 395                 400         

gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg     1248
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met         
                405                 410                 415             

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac     1296
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp         
            420                 425                 430                 

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat     1344
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His         
        435                 440                 445                     

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg     1392
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro         
    450                 455                 460                         

ggt aaa                                                             1398
Gly Lys                                                                 
465                                                                     


<210>  119
<211>  466
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  119

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Tyr Asn Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Ser Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  120
<211>  708
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3B1 LC sequence


<220>
<221>  CDS
<222>  (1)..(708)

<400>  120
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt gac atc cag atg acc cag tct cca tcc tcc       96
Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser         
            20                  25                  30                  

ctg tct gca tct gaa gga gac aga gtc acc atc act tgc cgg gca agt      144
Leu Ser Ala Ser Glu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser         
        35                  40                  45                      

cag ggc att aga aat gat tta ggc tgg tat cag cag aaa cca ggg aaa      192
Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys         
    50                  55                  60                          

gcc cct aag cgc ctg atc tat gct gca tcc agt ttg caa agt ggg gtc      240
Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val         
65                  70                  75                  80          

cca tta agg ttc agc ggc agt gga tct ggg aca gaa ttc act ctc aca      288
Pro Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr         
                85                  90                  95              

atc agc agc ctg cag cct gaa gat ttt gca act tat tac tgt cta cag      336
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln         
            100                 105                 110                 

tat aat agt tac ccg tgg acg ttc ggc caa ggg acc aag gtg gaa atc      384
Tyr Asn Ser Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile         
        115                 120                 125                     

aaa cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat      432
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp         
    130                 135                 140                         

gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac      480
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn         
145                 150                 155                 160         

ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc      528
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu         
                165                 170                 175             

caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac      576
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp         
            180                 185                 190                 

agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac      624
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr         
        195                 200                 205                     

gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc      672
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser         
    210                 215                 220                         

tcg ccc gtc aca aag agc ttc aac agg gga gag tgt                      708
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                         
225                 230                 235                             


<210>  121
<211>  236
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  121

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Glu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  122
<211>  1413
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3B1 HC sequence


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  122
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt cag gtg cag ctg cag gag tcg ggc cca gga       96
Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly         
            20                  25                  30                  

ctg gtt aag cct tcg gag acc ctg tcc ctc acc tgc act gtc tct ggt      144
Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly         
        35                  40                  45                      

ggc tcc atc agt agt tac tac tgg agc tgg atc cgg cag ccc cca ggg      192
Gly Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly         
    50                  55                  60                          

aag gga ctg gag tgg att ggg tat atc tat tac agt ggg aac acc aac      240
Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn         
65                  70                  75                  80          

tcc aac ccc tcc ctc aag agt cga gtc acc ata tca gta gac acg tcc      288
Ser Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser         
                85                  90                  95              

aag aac cag ttc tcc ctg aag ctg agc tct gtg acc gct gcg gac acg      336
Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr         
            100                 105                 110                 

gcc gtg tat tac tgt gcg aga acc tac tat gat agt agt ggt tac tac      384
Ala Val Tyr Tyr Cys Ala Arg Thr Tyr Tyr Asp Ser Ser Gly Tyr Tyr         
        115                 120                 125                     

tac cgt gct ttt gat atc tgg ggc caa ggg aca atg gtc acc gtc tct      432
Tyr Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser         
    130                 135                 140                         

agt gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc      480
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser         
145                 150                 155                 160         

agg agc acc tcc gag agc aca gcg gcc ctg ggc tgc ctg gtc aag gac      528
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp         
                165                 170                 175             

tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gct ctg acc      576
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr         
            180                 185                 190                 

agc ggc gtg cac acc ttc cca gct gtc cta cag tcc tca gga ctc tac      624
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr         
        195                 200                 205                     

tcc ctc agc agc gtg gtg acc gtg ccc tcc agc aac ttc ggc acc cag      672
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln         
    210                 215                 220                         

acc tac acc tgc aac gta gat cac aag ccc agc aac acc aag gtg gac      720
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp         
225                 230                 235                 240         

aag aca gtt gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc cca gca      768
Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala         
                245                 250                 255             

cca cct gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag      816
Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys         
            260                 265                 270                 

gac acc ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg      864
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val         
        275                 280                 285                     

gac gtg agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac      912
Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp         
    290                 295                 300                         

ggc gtg gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc      960
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe         
305                 310                 315                 320         

aac agc acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac     1008
Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp         
                325                 330                 335             

tgg ctg aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc     1056
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu         
            340                 345                 350                 

cca gcc ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga     1104
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg         
        355                 360                 365                     

gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag     1152
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys         
    370                 375                 380                         

aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tac ccc agc gac     1200
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp         
385                 390                 395                 400         

atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag     1248
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys         
                405                 410                 415             

acc aca cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc     1296
Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser         
            420                 425                 430                 

aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca     1344
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser         
        435                 440                 445                     

tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc     1392
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser         
    450                 455                 460                         

ctc tcc ctg tct ccg ggt aaa                                         1413
Leu Ser Leu Ser Pro Gly Lys                                             
465                 470                                                 


<210>  123
<211>  471
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  123

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn 
65                  70                  75                  80  


Ser Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Thr Tyr Tyr Asp Ser Ser Gly Tyr Tyr 
        115                 120                 125             


Tyr Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
145                 150                 155                 160 


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  124
<211>  708
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3C2 LC sequence


<220>
<221>  CDS
<222>  (1)..(708)

<400>  124
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt gac atc cag atg acc cag tct cca tcc tcc       96
Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser         
            20                  25                  30                  

ctg tct gca tct gta gga gac aga gtc acc atc act tgc cgg gcg agt      144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser         
        35                  40                  45                      

cag ggc atg agc aat tat tta gcc tgg tat cag cag aaa cca agg aaa      192
Gln Gly Met Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Arg Lys         
    50                  55                  60                          

gtt cct aag ctc ctg atc tat gct gca tcc act ttg caa tca ggg gtc      240
Val Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val         
65                  70                  75                  80          

cca tct cgg ttc agt ggc agt gga tct ggg aca gat ttc acc ctc acc      288
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr         
                85                  90                  95              

atc agc agc ctg cag ccg gaa gat gtt gca act tat tac tgt caa aag      336
Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys         
            100                 105                 110                 

ttt aac agt gcc cca ttc act ttc ggc cct ggg acc aaa gtg gat atc      384
Phe Asn Ser Ala Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile         
        115                 120                 125                     

aaa cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat      432
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp         
    130                 135                 140                         

gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac      480
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn         
145                 150                 155                 160         

ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc      528
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu         
                165                 170                 175             

caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac      576
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp         
            180                 185                 190                 

agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac      624
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr         
        195                 200                 205                     

gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc      672
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser         
    210                 215                 220                         

tcg ccc gtc aca aag agc ttc aac agg gga gag tgt                      708
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                         
225                 230                 235                             


<210>  125
<211>  236
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  125

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Met Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Arg Lys 
    50                  55                  60                  


Val Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys 
            100                 105                 110         


Phe Asn Ser Ala Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  126
<211>  708
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3H4 LC sequence


<220>
<221>  CDS
<222>  (1)..(708)

<400>  126
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt gac atc cag atg acc ctg tct cca tcc tcc       96
Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Leu Ser Pro Ser Ser         
            20                  25                  30                  

ctg tct gca tct gta gga gac aga gtc acc atc act tgc cgg gca agt      144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser         
        35                  40                  45                      

cag ggc att aga aat gat tta ggc tgg tat cag cag aaa cca ggg aaa      192
Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys         
    50                  55                  60                          

gcc cct aag cgc ctg atc tat gct gca tcc agt ttg caa agt ggg gtc      240
Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val         
65                  70                  75                  80          

cca tca agg ttc agc ggc agt gga tct ggg aca gaa ttc act ctc aca      288
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr         
                85                  90                  95              

atc agc agc ctg cag cct gaa gat ttt gca act tat tac tgt cta cag      336
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln         
            100                 105                 110                 

tat aat agt tcc ccg tgg acg ttc ggc caa ggg acc gag gtg gaa atc      384
Tyr Asn Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Glu Val Glu Ile         
        115                 120                 125                     

aaa cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat      432
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp         
    130                 135                 140                         

gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac      480
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn         
145                 150                 155                 160         

ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc      528
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu         
                165                 170                 175             

caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac      576
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp         
            180                 185                 190                 

agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac      624
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr         
        195                 200                 205                     

gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc      672
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser         
    210                 215                 220                         

tcg ccc gtc aca aag agc ttc aac agg gga gag tgt                      708
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                         
225                 230                 235                             


<210>  127
<211>  236
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  127

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Leu Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Asn Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Glu Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  128
<211>  1410
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3H4 HC sequence


<220>
<221>  CDS
<222>  (1)..(1410)

<400>  128
atg gac atg agg gtg ccc gct cag ctc ctg ggg ctc ctg ctg ctg tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctg aga ggt gcg cgc tgt cag gtg cag ctg cag gag tcg ggc cca gga       96
Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly         
            20                  25                  30                  

ctg gtg aag cct tta cag acc ctg tcc ctc acc tgc act gtc tct ggt      144
Leu Val Lys Pro Leu Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly         
        35                  40                  45                      

ggc tcc atc agc agt ggt ggt tat tac tgg agc tgg atc cgc cag cac      192
Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His         
    50                  55                  60                          

cca ggg aag ggc ctg gag tgg att ggg tac atc tat tac agt agg agc      240
Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Arg Ser         
65                  70                  75                  80          

acc tac tac aac ccg tcc ctc aag agt cga gtt acc ata tca gta gac      288
Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp         
                85                  90                  95              

acg tct aag aac cag ttc tcc ctg aag ctg agc tct gtg aca gcc gcg      336
Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala         
            100                 105                 110                 

gac acg gcc gtg tat tac tgt gcg aga acc ggg tat agc agt ggc tgg      384
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Gly Tyr Ser Ser Gly Trp         
        115                 120                 125                     

tac cct ttt gac tac tgg ggc cag gga acc ctg gtc acc gtc tct agt      432
Tyr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser         
    130                 135                 140                         

gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg      480
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg         
145                 150                 155                 160         

agc acc tcc gag agc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac      528
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr         
                165                 170                 175             

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gct ctg acc agc      576
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser         
            180                 185                 190                 

ggc gtg cac acc ttc cca gct gtc cta cag tcc tca gga ctc tac tcc      624
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser         
        195                 200                 205                     

ctc agc agc gtg gtg acc gtg ccc tcc agc aac ttc ggc acc cag acc      672
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr         
    210                 215                 220                         

tac acc tgc aac gta gat cac aag ccc agc aac acc aag gtg gac aag      720
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys         
225                 230                 235                 240         

aca gtt gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc cca gca cca      768
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro         
                245                 250                 255             

cct gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac      816
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp         
            260                 265                 270                 

acc ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac      864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp         
        275                 280                 285                     

gtg agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc      912
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly         
    290                 295                 300                         

gtg gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac      960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn         
305                 310                 315                 320         

agc acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg     1008
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp         
                325                 330                 335             

ctg aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca     1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro         
            340                 345                 350                 

gcc ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa     1104
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu         
        355                 360                 365                     

cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac     1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn         
    370                 375                 380                         

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc     1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile         
385                 390                 395                 400         

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc     1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr         
                405                 410                 415             

aca cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag     1296
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys         
            420                 425                 430                 

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc     1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys         
        435                 440                 445                     

tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc     1392
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu         
    450                 455                 460                         

tcc ctg tct ccg ggt aaa                                             1410
Ser Leu Ser Pro Gly Lys                                                 
465                 470                                                 


<210>  129
<211>  470
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  129

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Leu Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Arg Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Gly Tyr Ser Ser Gly Trp 
        115                 120                 125             


Tyr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
305                 310                 315                 320 


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  130
<211>  702
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 16.3.1 LC sequence


<220>
<221>  CDS
<222>  (1)..(702)

<400>  130
atg gac atg agg gtc cct gct cag ctc ctg ggg ctc ctg ctg ctc tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ctc tca ggt gcc aga tgt gac atc cag atg acc cag tct cca tcc tcc       96
Leu Ser Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser         
            20                  25                  30                  

ctg tct gta tct gtg gga gac aga gtc acc atc act tgc cag gcg ggt      144
Leu Ser Val Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Gly         
        35                  40                  45                      

cag gac att cgc aac tat tta aat tgg tat cag cag aaa cca ggg aaa      192
Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys         
    50                  55                  60                          

gcc cct aaa ctc ctg atc tac gat gca tcc aat ttg gaa aca ggg gtc      240
Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val         
65                  70                  75                  80          

cca tca agg ttc agt gga agt gga tct ggg aca gct ttt act ttc acc      288
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Phe Thr         
                85                  90                  95              

atc agc agc ctg cag cct gaa gat att gca aca tat tac tgt caa cag      336
Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln         
            100                 105                 110                 

tat gat aat ctc act ttt ggc cag ggg acc aaa ctg gag atc aaa cga      384
Tyr Asp Asn Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg         
        115                 120                 125                     

act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag cag      432
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln         
    130                 135                 140                         

ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc tat      480
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr         
145                 150                 155                 160         

ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa tcg      528
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser         
                165                 170                 175             

ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc acc      576
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr         
            180                 185                 190                 

tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag aaa      624
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys         
        195                 200                 205                     

cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg ccc      672
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro         
    210                 215                 220                         

gtc aca aag agc ttc aac agg gga gag tgt                              702
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                                 
225                 230                                                 


<210>  131
<211>  234
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  131

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Val Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Gly 
        35                  40                  45              


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Phe Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asp Asn Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  132
<211>  1389
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 16.3.1 HC sequence


<220>
<221>  CDS
<222>  (1)..(1389)

<400>  132
atg gaa ttg gga ctg agc tgg gtt ttc ctt ttt gct ata tta gaa ggt       48
Met Glu Leu Gly Leu Ser Trp Val Phe Leu Phe Ala Ile Leu Glu Gly         
1               5                   10                  15              

gtc cag tgt gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag       96
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln         
            20                  25                  30                  

cct ggg ggg tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc      144
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe         
        35                  40                  45                      

agt aac tac gac atg tac tgg gtc cgc caa act aca gga aaa ggt ctg      192
Ser Asn Tyr Asp Met Tyr Trp Val Arg Gln Thr Thr Gly Lys Gly Leu         
    50                  55                  60                          

gag tgg gtc tca gct att ggt act gct ggt gac aca tac tat cca ggc      240
Glu Trp Val Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly         
65                  70                  75                  80          

tcc gtg aag ggc cga ttc acc atc tcc aga gaa aat gcc aag aac tcc      288
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser         
                85                  90                  95              

ttg tat ctt caa atg aac agc ctg aga gcc ggg gac acg gct gtg tat      336
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr         
            100                 105                 110                 

tac tgt gca aga gag aag tct agc acc tcg gcc ttt gac tac tgg ggc      384
Tyr Cys Ala Arg Glu Lys Ser Ser Thr Ser Ala Phe Asp Tyr Trp Gly         
        115                 120                 125                     

cag gga acc ctg gtc acc gtc tcc tca gcc tcc acc aag ggc cca tcg      432
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser         
    130                 135                 140                         

gtc ttc ccc ctg gcg ccc tgc tcc agg agc acc tcc gag agc aca gcg      480
Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala         
145                 150                 155                 160         

gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg      528
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val         
                165                 170                 175             

tcg tgg aac tca ggc gct ctg acc agc ggc gtg cac acc ttc cca gct      576
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala         
            180                 185                 190                 

gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc gtg      624
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val         
        195                 200                 205                     

ccc tcc agc aac ttc ggc acc cag acc tac acc tgc aac gta gat cac      672
Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His         
    210                 215                 220                         

aag ccc agc aac acc aag gtg gac aag aca gtt gag cgc aaa tgt tgt      720
Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys         
225                 230                 235                 240         

gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga ccg tca gtc      768
Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val         
                245                 250                 255             

ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc      816
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr         
            260                 265                 270                 

cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa gac ccc gag      864
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu         
        275                 280                 285                     

gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag      912
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys         
    290                 295                 300                         

aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt gtg gtc agc      960
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser         
305                 310                 315                 320         

gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag gag tac aag     1008
Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys         
                325                 330                 335             

tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag aaa acc atc     1056
Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile         
            340                 345                 350                 

tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc     1104
Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro         
        355                 360                 365                     

cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg acc tgc ctg     1152
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu         
    370                 375                 380                         

gtc aaa ggc ttc tac ccc agc gac atc gcc gtg gag tgg gag agc aat     1200
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn         
385                 390                 395                 400         

ggg cag ccg gag aac aac tac aag acc aca cct ccc atg ctg gac tcc     1248
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser         
                405                 410                 415             

gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg     1296
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg         
            420                 425                 430                 

tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg     1344
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu         
        435                 440                 445                     

cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa         1389
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys             
    450                 455                 460                         


<210>  133
<211>  463
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  133

Met Glu Leu Gly Leu Ser Trp Val Phe Leu Phe Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Asp Met Tyr Trp Val Arg Gln Thr Thr Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Lys Ser Ser Thr Ser Ala Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  134
<211>  708
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 108.1.2 LC sequence


<220>
<221>  CDS
<222>  (1)..(708)

<400>  134
atg gaa acc cca gcg cag ctt ctc ttc ctc ctg cta ctc tgg ctc cca       48
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro         
1               5                   10                  15              

gat acc acc gga gaa att gtg ttg acg cag tct cca ggc acc ctg tct       96
Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser         
            20                  25                  30                  

ttg tct cca ggg gaa aga gcc acc ctc tcc tgt agg gcc agt cag aat      144
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn         
        35                  40                  45                      

att agc acc aac tac tta gcc tgg tac cag cag aaa cct ggc cag gct      192
Ile Ser Thr Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala         
    50                  55                  60                          

ccc agg ttc ctc att tat ggt gca tcc agc agg gcc act ggc atc cca      240
Pro Arg Phe Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro         
65                  70                  75                  80          

gac agg ttc agt ggc agt ggg tct ggg aca gac ttc act ctc acc atc      288
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile         
                85                  90                  95              

agc aga ctg gag cct gaa gat ttt gca gtg tat tac tgt cag cag ttt      336
Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe         
            100                 105                 110                 

ggg cgc tca cct cgg tgc agt ttt ggc cag ggg acc aag ctg gag atc      384
Gly Arg Ser Pro Arg Cys Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile         
        115                 120                 125                     

aaa cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat      432
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp         
    130                 135                 140                         

gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac      480
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn         
145                 150                 155                 160         

ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc      528
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu         
                165                 170                 175             

caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac      576
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp         
            180                 185                 190                 

agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac      624
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr         
        195                 200                 205                     

gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc      672
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser         
    210                 215                 220                         

tcg ccc gtc aca aag agc ttc aac agg gga gag tgt                      708
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                         
225                 230                 235                             


<210>  135
<211>  236
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  135

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn 
        35                  40                  45              


Ile Ser Thr Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Phe Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe 
            100                 105                 110         


Gly Arg Ser Pro Arg Cys Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  136
<211>  708
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 108.1.2 (N>Q, C>S) LC sequence


<220>
<221>  CDS
<222>  (1)..(708)

<400>  136
atg gaa acc cca gcg cag ctt ctc ttc ctc ctg cta ctc tgg ctc cca       48
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro         
1               5                   10                  15              

gat acc acc gga gaa att gtg ttg acg cag tct cca ggc acc ctg tct       96
Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser         
            20                  25                  30                  

ttg tct cca ggg gaa aga gcc acc ctc tcc tgt agg gcc agt cag caa      144
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gln         
        35                  40                  45                      

att agc acc aac tac tta gcc tgg tac cag cag aaa cct ggc cag gct      192
Ile Ser Thr Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala         
    50                  55                  60                          

ccc agg ttc ctc att tat ggt gca tcc agc agg gcc act ggc atc cca      240
Pro Arg Phe Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro         
65                  70                  75                  80          

gac agg ttc agt ggc agt ggg tct ggg aca gac ttc act ctc acc atc      288
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile         
                85                  90                  95              

agc aga ctg gag cct gaa gat ttt gca gtg tat tac tgt cag cag ttt      336
Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe         
            100                 105                 110                 

ggg cgc tca cct cgg agc agt ttt ggc cag ggg acc aag ctg gag atc      384
Gly Arg Ser Pro Arg Ser Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile         
        115                 120                 125                     

aaa cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat      432
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp         
    130                 135                 140                         

gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac      480
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn         
145                 150                 155                 160         

ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc      528
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu         
                165                 170                 175             

caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac      576
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp         
            180                 185                 190                 

agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac      624
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr         
        195                 200                 205                     

gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc      672
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser         
    210                 215                 220                         

tcg ccc gtc aca aag agc ttc aac agg gga gag tgt                      708
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                         
225                 230                 235                             


<210>  137
<211>  236
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  137

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gln 
        35                  40                  45              


Ile Ser Thr Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Phe Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe 
            100                 105                 110         


Gly Arg Ser Pro Arg Ser Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  138
<211>  1410
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 108.1.2 HC sequence


<220>
<221>  CDS
<222>  (1)..(1410)

<400>  138
atg aag cac ctg tgg ttc ttc ctc ctg ctg gtg gcg gct ccc aga tgg       48
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp         
1               5                   10                  15              

gtc ctg tcc cag ctg cag ctg caa gag tcg ggc cca gga ctg atg aag       96
Val Leu Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Met Lys         
            20                  25                  30                  

cct tcg gag acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc      144
Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile         
        35                  40                  45                      

agc agt agt agt tac ttc tgg ggc tgg atc cgc cag ccc cca ggg aag      192
Ser Ser Ser Ser Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys         
    50                  55                  60                          

gga ctg gag tgg att ggg agt atc tat tat agt ggg aac acc ttc tac      240
Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Asn Thr Phe Tyr         
65                  70                  75                  80          

aac ccg tcc ctc aag agt cga gtc acc ata tcc gtt gac acg tcc aag      288
Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys         
                85                  90                  95              

aac cag ttc tcc ctg aag ctt aac tct atg acc gcc gca gac acg gct      336
Asn Gln Phe Ser Leu Lys Leu Asn Ser Met Thr Ala Ala Asp Thr Ala         
            100                 105                 110                 

gtg tat ttc tgt gcg aga caa ggg ggt ata gca gct cgt acc gga tac      384
Val Tyr Phe Cys Ala Arg Gln Gly Gly Ile Ala Ala Arg Thr Gly Tyr         
        115                 120                 125                     

tgg tac ttc gat ctc tgg ggc cgt ggc acc acg gtc acc gtc tcc tca      432
Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser         
    130                 135                 140                         

gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg      480
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg         
145                 150                 155                 160         

agc acc tcc gag agc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac      528
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr         
                165                 170                 175             

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gct ctg acc agc      576
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser         
            180                 185                 190                 

ggc gtg cac acc ttc cca gct gtc cta cag tcc tca gga ctc tac tcc      624
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser         
        195                 200                 205                     

ctc agc agc gtg gtg acc gtg ccc tcc agc aac ttc ggc acc cag acc      672
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr         
    210                 215                 220                         

tac acc tgc aac gta gat cac aag ccc agc aac acc aag gtg gac aag      720
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys         
225                 230                 235                 240         

aca gtt gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc cca gca cca      768
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro         
                245                 250                 255             

cct gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac      816
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp         
            260                 265                 270                 

acc ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac      864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp         
        275                 280                 285                     

gtg agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc      912
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly         
    290                 295                 300                         

gtg gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac      960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn         
305                 310                 315                 320         

agc acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg     1008
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp         
                325                 330                 335             

ctg aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca     1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro         
            340                 345                 350                 

gcc ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa     1104
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu         
        355                 360                 365                     

cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac     1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn         
    370                 375                 380                         

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc     1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile         
385                 390                 395                 400         

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc     1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr         
                405                 410                 415             

aca cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag     1296
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys         
            420                 425                 430                 

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc     1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys         
        435                 440                 445                     

tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc     1392
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu         
    450                 455                 460                         

tcc ctg tct ccg ggt aaa                                             1410
Ser Leu Ser Pro Gly Lys                                                 
465                 470                                                 


<210>  139
<211>  470
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  139

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Met Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Ser Ser Ser Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Asn Thr Phe Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Asn Ser Met Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Gln Gly Gly Ile Ala Ala Arg Thr Gly Tyr 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
305                 310                 315                 320 


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  140
<211>  708
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 LC sequence


<220>
<221>  CDS
<222>  (1)..(708)

<400>  140
atg gac atg agg gtc ccc gct cag ctc ctg ggg ctc ctg ctg ctc tgg       48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp         
1               5                   10                  15              

ttc cca ggt gcc agg tgt gac atc cag atg acc cag tct cca tcc tcc       96
Phe Pro Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser         
            20                  25                  30                  

ctg tct gca tct gta gga gac aga gtc acc atc act tgc cgg gca agt      144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser         
        35                  40                  45                      

cag ggc att aga aat gat tta ggc tgg tat cag cag aaa cca ggg aaa      192
Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys         
    50                  55                  60                          

gcc cct aaa cgc ctg atc tat gct gca tcc agt ttg caa agt ggg gtc      240
Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val         
65                  70                  75                  80          

cca tca agg ttc agc ggc agt gga tct ggg aca gaa ttc act ctc aca      288
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr         
                85                  90                  95              

atc agc agc ctg cag cct gaa gat ttt gca act tat tac tgt cta cag      336
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln         
            100                 105                 110                 

cat aat agt tac ccg ctc act ttc ggc gga ggg acc aag gtg gag atc      384
His Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile         
        115                 120                 125                     

aaa cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat      432
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp         
    130                 135                 140                         

gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac      480
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn         
145                 150                 155                 160         

ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc      528
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu         
                165                 170                 175             

caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac      576
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp         
            180                 185                 190                 

agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac      624
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr         
        195                 200                 205                     

gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc      672
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser         
    210                 215                 220                         

tcg ccc gtc aca aag agc ttc aac agg gga gag tgt                      708
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                         
225                 230                 235                             


<210>  141
<211>  236
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  141

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


His Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  142
<211>  1392
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 HC sequence


<220>
<221>  CDS
<222>  (1)..(1392)

<400>  142
atg gac tgg acc tgg agg atc ctc ttc ttg gtg gca gca gcc aca gga       48
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly         
1               5                   10                  15              

gcc cac tcc cag gtg cag ctg gtg cag tct ggg gct gag gtg aag aag       96
Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys         
            20                  25                  30                  

cct ggg gcc tca gtg aag gtc tcc tgc aag gct tct gga tac acc ttc      144
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe         
        35                  40                  45                      

acc ggc tac cac atg cac tgg gtg cga cag gcc cct gga caa ggg ctt      192
Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu         
    50                  55                  60                          

gag tgg atg gga tgg atc aac cct aac agt ggt ggc aca aac tat gca      240
Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala         
65                  70                  75                  80          

cag aag ttt cag ggc agg gtc acc atg acc agg gac acg tcc atc agc      288
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser         
                85                  90                  95              

aca gcc tac atg gag ctg agc agg ctg aga tct gac gac acg gcc gtg      336
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val         
            100                 105                 110                 

tat tac tgt gcg aga gat cgt ggg agc tac tac tgg ttc gac ccc tgg      384
Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe Asp Pro Trp         
        115                 120                 125                     

ggc cag gga acc ctg gtc acc gtc tcc tca gcc tcc acc aag ggc cca      432
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro         
    130                 135                 140                         

tcg gtc ttc ccc ctg gcg ccc tgc tcc agg agc acc tcc gag agc aca      480
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr         
145                 150                 155                 160         

gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg      528
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr         
                165                 170                 175             

gtg tcg tgg aac tca ggc gct ctg acc agc ggc gtg cac acc ttc cca      576
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro         
            180                 185                 190                 

gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc      624
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr         
        195                 200                 205                     

gtg ccc tcc agc aac ttc ggc acc cag acc tac acc tgc aac gta gat      672
Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp         
    210                 215                 220                         

cac aag ccc agc aac acc aag gtg gac aag aca gtt gag cgc aaa tgt      720
His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys         
225                 230                 235                 240         

tgt gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga ccg tca      768
Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser         
                245                 250                 255             

gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg      816
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg         
            260                 265                 270                 

acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa gac ccc      864
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro         
        275                 280                 285                     

gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc      912
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala         
    290                 295                 300                         

aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt gtg gtc      960
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val         
305                 310                 315                 320         

agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag gag tac     1008
Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr         
                325                 330                 335             

aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag aaa acc     1056
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr         
            340                 345                 350                 

atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg     1104
Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu         
        355                 360                 365                     

ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg acc tgc     1152
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys         
    370                 375                 380                         

ctg gtc aaa ggc ttc tac ccc agc gac atc gcc gtg gag tgg gag agc     1200
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser         
385                 390                 395                 400         

aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg ctg gac     1248
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp         
                405                 410                 415             

tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc     1296
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser         
            420                 425                 430                 

agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct     1344
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala         
        435                 440                 445                     

ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa     1392
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys         
    450                 455                 460                         


<210>  143
<211>  464
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  143

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe Asp Pro Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
225                 230                 235                 240 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  144
<211>  469
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3A1 HC protein sequence

<400>  144

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser His Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Gly Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ala Arg Gly Asp Gly Tyr Asn Tyr Pro 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
305                 310                 315                 320 


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  145
<211>  465
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3A4 HC protein sequence

<400>  145

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Trp Asn Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly 
465 


<210>  146
<211>  25
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence "L25"

<400>  146

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  147
<211>  20
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence "L20"

<400>  147

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  148
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa in positions 1 and 2 are each independently any amino acid 
       residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Xaa in positions 1 and 2 are each independently any amino acid 
       residue

<400>  148

Xaa Xaa Asn Xaa Xaa Gly 
1               5       


<210>  149
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  149

Gly Gly Gly Gly 
1               


<210>  150
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  150

Gly Gly Gly Gly Gly 
1               5   


<210>  151
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  151

Gly Gly Gly Gly Gly Gly Gly 
1               5           


<210>  152
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence "L5"

<400>  152

Gly Gly Gly Gly Ser 
1               5   


<210>  153
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  153

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  154
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  154

Gly Gly Gly Gly Gly Lys 
1               5       


<210>  155
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  155

Gly Gly Gly Gly Gly Lys Arg 
1               5           


<210>  156
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  156

Gly Gly Gly Asn Gly Ser Gly Gly 
1               5               


<210>  157
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  157

Gly Gly Gly Cys Gly Gly Gly Gly 
1               5               


<210>  158
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  158

Gly Pro Asn Gly Gly 
1               5   


<210>  159
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  159

Gly Gly Gly Lys Gly Gly Gly Gly 
1               5               


<210>  160
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  160

Gly Gly Glu Gly Gly Gly 
1               5       


<210>  161
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  161

Gly Gly Glu Glu Glu Gly Gly Gly 
1               5               


<210>  162
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  162

Gly Glu Glu Glu Gly 
1               5   


<210>  163
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  163

Gly Glu Glu Glu 
1               


<210>  164
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  164

Gly Gly Asp Gly Gly Gly 
1               5       


<210>  165
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  165

Gly Gly Asp Asp Asp Gly Gly 
1               5           


<210>  166
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  166

Gly Asp Asp Asp Gly 
1               5   


<210>  167
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  167

Gly Asp Asp Asp 
1               


<210>  168
<211>  21
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  168

Gly Gly Gly Gly Ser Asp Asp Ser Asp Glu Gly Ser Asp Gly Glu Asp 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  169
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  169

Trp Glu Trp Glu Trp 
1               5   


<210>  170
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  170

Phe Glu Phe Glu Phe 
1               5   


<210>  171
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  171

Glu Glu Glu Trp Trp Trp 
1               5       


<210>  172
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  172

Glu Glu Glu Phe Phe Phe 
1               5       


<210>  173
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  173

Trp Trp Glu Glu Glu Trp Trp 
1               5           


<210>  174
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  174

Phe Phe Glu Glu Glu Phe Phe 
1               5           


<210>  175
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa in positions 1 and 2 are each independently any amino acid 
       residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Xaa in positions 1 and 2 are each independently any amino acid 
       residue

<400>  175

Xaa Xaa Tyr Xaa Xaa Gly 
1               5       


<210>  176
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa in positions 1 and 2 are each independently any amino acid 
       residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Xaa in positions 1 and 2 are each independently any amino acid 
       residue

<400>  176

Xaa Xaa Ser Xaa Xaa Gly 
1               5       


<210>  177
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa in positions 1 and 2 are each independently any amino acid 
       residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Xaa in positions 1 and 2 are each independently any amino acid 
       residue

<400>  177

Xaa Xaa Thr Xaa Xaa Gly 
1               5       


<210>  178
<211>  22
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  178

Gly Ser Gly Ser Ala Thr Gly Gly Ser Gly Ser Thr Ala Ser Ser Gly 
1               5                   10                  15      


Ser Gly Ser Ala Thr His 
            20          


<210>  179
<211>  22
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  179

His Gly Ser Gly Ser Ala Thr Gly Gly Ser Gly Ser Thr Ala Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Ala Thr 
            20          


<210>  180
<211>  19
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker sequence

<400>  180

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Ala Gly Gly 
            


<210>  181
<211>  465
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aDNP 3A4 (W101Y) HC (H12) protein sequence

<400>  181

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Tyr Asn Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly 
465 


<210>  182
<211>  465
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  H13 protein sequence

<400>  182

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Phe Asn Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Ser Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly 
465 


<210>  183
<211>  465
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  H14 protein sequence

<400>  183

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asn Tyr Asn Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Ser Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly 
465 


<210>  184
<211>  470
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  H15 protein sequence

<400>  184

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn 
65                  70                  75                  80  


Ser Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Thr Tyr Tyr Asp Ser Ser Gly Tyr Tyr 
        115                 120                 125             


Tyr Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
145                 150                 155                 160 


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  185
<211>  469
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  H16 protein sequence

<400>  185

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Leu Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Arg Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Gly Tyr Ser Ser Gly Trp 
        115                 120                 125             


Tyr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
305                 310                 315                 320 


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  186
<211>  462
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  H21 protein sequence

<400>  186

Met Glu Leu Gly Leu Ser Trp Val Phe Leu Phe Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Asp Met Tyr Trp Val Arg Gln Thr Thr Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Lys Ser Ser Thr Ser Ala Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460         


<210>  187
<211>  469
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  H22 protein sequence

<400>  187

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Met Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Ser Ser Ser Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Asn Thr Phe Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Asn Ser Met Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Gln Gly Gly Ile Ala Ala Arg Thr Gly Tyr 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
305                 310                 315                 320 


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  188
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 1-1

<400>  188

His Tyr Tyr Trp Ser 
1               5   


<210>  189
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 1-2

<400>  189

Ser Tyr Gly Met His 
1               5   


<210>  190
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 1-3

<400>  190

Ser Tyr Tyr Trp Ser 
1               5   


<210>  191
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 1-4

<400>  191

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  192
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 2-1

<400>  192

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  193
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 2-2

<400>  193

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  194
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 2-3

<400>  194

Val Ile Tyr Tyr Ser Gly Asn Thr Asn Ser Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  195
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 2-4

<400>  195

Tyr Ile Tyr Tyr Ser Arg Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  196
<211>  14
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 3-1

<400>  196

Ala Arg Gly Asp Gly Tyr Asn Tyr Pro Asp Ala Phe Asp Ile 
1               5                   10                  


<210>  197
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 3-2

<400>  197

Tyr Asn Trp Asn Tyr Gly Met Asp Val 
1               5                   


<210>  198
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 3-3

<400>  198

Tyr Asn Phe Asn Tyr Gly Met Asp Val 
1               5                   


<210>  199
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 3-4

<400>  199

Tyr Asn Tyr Asn Tyr Gly Met Asp Val 
1               5                   


<210>  200
<211>  15
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 3-5

<400>  200

Thr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Arg Ala Phe Asp Ile 
1               5                   10                  15  


<210>  201
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 3-6

<400>  201

Thr Gly Tyr Ser Ser Gly Trp Tyr Pro Phe Asp Tyr 
1               5                   10          


<210>  202
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 1-1

<400>  202

Arg Ala Ser Gln Gly Ile Ser Asn Trp Leu Ala 
1               5                   10      


<210>  203
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 1-2

<400>  203

Arg Ala Ser Gln Gly Ile Ser Arg Arg Leu Ala 
1               5                   10      


<210>  204
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 1-3; CDRL 1-8

<400>  204

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  205
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 1-4

<400>  205

Arg Ala Ser Gln Gly Met Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  206
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 2-1; CDRL 2-5

<400>  206

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  207
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 2-2

<400>  207

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  208
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 3-1

<400>  208

Gln Gln Ala Ser Ser Phe Pro Trp Thr 
1               5                   


<210>  209
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 3-2

<400>  209

Gln Gln Ala Asn Ser Phe Pro Phe Thr 
1               5                   


<210>  210
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 3-3

<400>  210

Leu Gln Tyr Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  211
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 3-4

<400>  211

Gln Lys Phe Asn Ser Ala Pro Phe Thr 
1               5                   


<210>  212
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 3-5

<400>  212

Leu Gln Tyr Asn Ser Ser Pro Trp Thr 
1               5                   


<210>  213
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 1-5

<400>  213

Asn Tyr Asp Met Tyr 
1               5   


<210>  214
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 1-6

<400>  214

Ser Ser Ser Tyr Phe Trp Gly 
1               5           


<210>  215
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 1-7

<400>  215

Gly Tyr His Met His 
1               5   


<210>  216
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 2-5

<400>  216

Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys Gly 
1               5                   10                  15      


<210>  217
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 2-6

<400>  217

Ser Ile Tyr Tyr Ser Gly Asn Thr Phe Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  218
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 2-7

<400>  218

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  219
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 3-7

<400>  219

Glu Lys Ser Ser Thr Ser Ala Phe Asp Tyr 
1               5                   10  


<210>  220
<211>  15
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 3-8

<400>  220

Gln Gly Gly Ile Ala Ala Arg Thr Gly Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  15  


<210>  221
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH 3-9

<400>  221

Asp Arg Gly Ser Tyr Tyr Trp Phe Asp Pro 
1               5                   10  


<210>  222
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 1-5

<400>  222

Gln Ala Gly Gln Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  223
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 1-6

<400>  223

Arg Ala Ser Gln Asn Ile Ser Thr Asn Tyr Leu Ala 
1               5                   10          


<210>  224
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 1-7

<400>  224

Arg Ala Ser Gln Gln Ile Ser Thr Asn Tyr Leu Ala 
1               5                   10          


<210>  225
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 2-3

<400>  225

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  226
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 2-4

<400>  226

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  227
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 3-6

<400>  227

Gln Gln Tyr Asp Asn Leu Thr 
1               5           


<210>  228
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 3-7

<400>  228

Gln Gln Phe Gly Arg Ser Pro Arg Cys Ser 
1               5                   10  


<210>  229
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 3-8

<400>  229

Gln Gln Phe Gly Arg Ser Pro Arg Ser Ser 
1               5                   10  


<210>  230
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL 3-9

<400>  230

Leu Gln His Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  231
<211>  321
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL1 coding sequence


<220>
<221>  CDS
<222>  (1)..(321)

<400>  231
gac atc cag atg acc cag tct cca tct tcc gtg tct gca tct gta ggt       48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly         
1               5                   10                  15              

gac aga gtc acc atc act tgt cgg gcg agt cag ggt att agc aac tgg       96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Trp         
            20                  25                  30                  

tta gcc tgg tat cag cgg aaa cca ggg aaa gcc cct aag ctc ctg atc      144
Leu Ala Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile         
        35                  40                  45                      

tat gct gca tcc agt ttg caa agt ggg gtc cca tca agg ttc agc ggc      192
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly         
    50                  55                  60                          

agt gga tct ggg aca gat ttc act ctc acc atc agc agc ctg cag cct      240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro         
65                  70                  75                  80          

gaa gat ttt gca gct tac tat tgt caa cag gct agc agt ttc ccg tgg      288
Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln Ala Ser Ser Phe Pro Trp         
                85                  90                  95              

acg ttc ggc caa ggg acc agg gtg gaa atc aaa                          321
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys                             
            100                 105                                     


<210>  232
<211>  107
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  232

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln Ala Ser Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys 
            100                 105         


<210>  233
<211>  321
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL2 coding sequence


<220>
<221>  CDS
<222>  (1)..(321)

<400>  233
gac atc cag atg acc cag tct cca tct tcc gtg tct gca tct gta gga       48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly         
1               5                   10                  15              

gac aga gtc acc atc act tgt cgg gcg agt cag ggt att agt agg agg       96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Arg         
            20                  25                  30                  

tta gcc tgg tat cag cag aaa cca ggg aaa gcc cct aag ctc ctg atc      144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile         
        35                  40                  45                      

tat gct gca tcc agt ttg caa agt ggg gtc cca tca agg ttc agc ggc      192
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly         
    50                  55                  60                          

agt gga tct ggg aca gat ttc act ctc acc atc agc agc ctg cag cct      240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro         
65                  70                  75                  80          

gaa gat ttt gca act tac tat tgt caa cag gct aac agt ttc cct ttc      288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe         
                85                  90                  95              

act ttc ggc cct ggg acc aaa gtg gat atc aaa                          321
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys                             
            100                 105                                     


<210>  234
<211>  107
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  234

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  235
<211>  321
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL3 coding sequence


<220>
<221>  CDS
<222>  (1)..(321)

<400>  235
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gaa gga       48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Glu Gly         
1               5                   10                  15              

gac aga gtc acc atc act tgc cgg gca agt cag ggc att aga aat gat       96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp         
            20                  25                  30                  

tta ggc tgg tat cag cag aaa cca ggg aaa gcc cct aag cgc ctg atc      144
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile         
        35                  40                  45                      

tat gct gca tcc agt ttg caa agt ggg gtc cca tta agg ttc agc ggc      192
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Leu Arg Phe Ser Gly         
    50                  55                  60                          

agt gga tct ggg aca gaa ttc act ctc aca atc agc agc ctg cag cct      240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro         
65                  70                  75                  80          

gaa gat ttt gca act tat tac tgt cta cag tat aat agt tac ccg tgg      288
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asn Ser Tyr Pro Trp         
                85                  90                  95              

acg ttc ggc caa ggg acc aag gtg gaa atc aaa                          321
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                             
            100                 105                                     


<210>  236
<211>  107
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  236

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Leu Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  237
<211>  321
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL4 coding sequence


<220>
<221>  CDS
<222>  (1)..(321)

<400>  237
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gta gga       48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly         
1               5                   10                  15              

gac aga gtc acc atc act tgc cgg gcg agt cag ggc atg agc aat tat       96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Met Ser Asn Tyr         
            20                  25                  30                  

tta gcc tgg tat cag cag aaa cca agg aaa gtt cct aag ctc ctg atc      144
Leu Ala Trp Tyr Gln Gln Lys Pro Arg Lys Val Pro Lys Leu Leu Ile         
        35                  40                  45                      

tat gct gca tcc act ttg caa tca ggg gtc cca tct cgg ttc agt ggc      192
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly         
    50                  55                  60                          

agt gga tct ggg aca gat ttc acc ctc acc atc agc agc ctg cag ccg      240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro         
65                  70                  75                  80          

gaa gat gtt gca act tat tac tgt caa aag ttt aac agt gcc cca ttc      288
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Phe Asn Ser Ala Pro Phe         
                85                  90                  95              

act ttc ggc cct ggg acc aaa gtg gat atc aaa                          321
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys                             
            100                 105                                     


<210>  238
<211>  107
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  238

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Met Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Arg Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Phe Asn Ser Ala Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  239
<211>  321
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL5 coding sequence


<220>
<221>  CDS
<222>  (1)..(321)

<400>  239
gac atc cag atg acc ctg tct cca tcc tcc ctg tct gca tct gta gga       48
Asp Ile Gln Met Thr Leu Ser Pro Ser Ser Leu Ser Ala Ser Val Gly         
1               5                   10                  15              

gac aga gtc acc atc act tgc cgg gca agt cag ggc att aga aat gat       96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp         
            20                  25                  30                  

tta ggc tgg tat cag cag aaa cca ggg aaa gcc cct aag cgc ctg atc      144
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile         
        35                  40                  45                      

tat gct gca tcc agt ttg caa agt ggg gtc cca tca agg ttc agc ggc      192
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly         
    50                  55                  60                          

agt gga tct ggg aca gaa ttc act ctc aca atc agc agc ctg cag cct      240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro         
65                  70                  75                  80          

gaa gat ttt gca act tat tac tgt cta cag tat aat agt tcc ccg tgg      288
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asn Ser Ser Pro Trp         
                85                  90                  95              

acg ttc ggc caa ggg acc gag gtg gaa atc aaa                          321
Thr Phe Gly Gln Gly Thr Glu Val Glu Ile Lys                             
            100                 105                                     


<210>  240
<211>  107
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  240

Asp Ile Gln Met Thr Leu Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asn Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Glu Val Glu Ile Lys 
            100                 105         


<210>  241
<211>  315
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL6 coding sequence


<220>
<221>  CDS
<222>  (1)..(315)

<400>  241
gac atc cag atg acc cag tct cca tcc tcc ctg tct gta tct gtg gga       48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly         
1               5                   10                  15              

gac aga gtc acc atc act tgc cag gcg ggt cag gac att cgc aac tat       96
Asp Arg Val Thr Ile Thr Cys Gln Ala Gly Gln Asp Ile Arg Asn Tyr         
            20                  25                  30                  

tta aat tgg tat cag cag aaa cca ggg aaa gcc cct aaa ctc ctg atc      144
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile         
        35                  40                  45                      

tac gat gca tcc aat ttg gaa aca ggg gtc cca tca agg ttc agt gga      192
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly         
    50                  55                  60                          

agt gga tct ggg aca gct ttt act ttc acc atc agc agc ctg cag cct      240
Ser Gly Ser Gly Thr Ala Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro         
65                  70                  75                  80          

gaa gat att gca aca tat tac tgt caa cag tat gat aat ctc act ttt      288
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Thr Phe         
                85                  90                  95              

ggc cag ggg acc aaa ctg gag atc aaa                                  315
Gly Gln Gly Thr Lys Leu Glu Ile Lys                                     
            100                 105                                     


<210>  242
<211>  105
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  242

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Gly Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Ala Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  243
<211>  327
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL7 coding sequence


<220>
<221>  CDS
<222>  (1)..(327)

<400>  243
gaa att gtg ttg acg cag tct cca ggc acc ctg tct ttg tct cca ggg       48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly         
1               5                   10                  15              

gaa aga gcc acc ctc tcc tgt agg gcc agt cag aat att agc acc aac       96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Ser Thr Asn         
            20                  25                  30                  

tac tta gcc tgg tac cag cag aaa cct ggc cag gct ccc agg ttc ctc      144
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Phe Leu         
        35                  40                  45                      

att tat ggt gca tcc agc agg gcc act ggc atc cca gac agg ttc agt      192
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser         
    50                  55                  60                          

ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag      240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu         
65                  70                  75                  80          

cct gaa gat ttt gca gtg tat tac tgt cag cag ttt ggg cgc tca cct      288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Arg Ser Pro         
                85                  90                  95              

cgg tgc agt ttt ggc cag ggg acc aag ctg gag atc aaa                  327
Arg Cys Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                     
            100                 105                                     


<210>  244
<211>  109
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  244

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Ser Thr Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Phe Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Arg Ser Pro 
                85                  90                  95      


Arg Cys Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  245
<211>  327
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL8 coding sequence


<220>
<221>  CDS
<222>  (1)..(327)

<400>  245
gaa att gtg ttg acg cag tct cca ggc acc ctg tct ttg tct cca ggg       48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly         
1               5                   10                  15              

gaa aga gcc acc ctc tcc tgt agg gcc agt cag caa att agc acc aac       96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gln Ile Ser Thr Asn         
            20                  25                  30                  

tac tta gcc tgg tac cag cag aaa cct ggc cag gct ccc agg ttc ctc      144
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Phe Leu         
        35                  40                  45                      

att tat ggt gca tcc agc agg gcc act ggc atc cca gac agg ttc agt      192
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser         
    50                  55                  60                          

ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag      240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu         
65                  70                  75                  80          

cct gaa gat ttt gca gtg tat tac tgt cag cag ttt ggg cgc tca cct      288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Arg Ser Pro         
                85                  90                  95              

cgg agc agt ttt ggc cag ggg acc aag ctg gag atc aaa                  327
Arg Ser Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                     
            100                 105                                     


<210>  246
<211>  109
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  246

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gln Ile Ser Thr Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Phe Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Arg Ser Pro 
                85                  90                  95      


Arg Ser Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  247
<211>  321
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL9 coding sequence


<220>
<221>  CDS
<222>  (1)..(321)

<400>  247
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gta gga       48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly         
1               5                   10                  15              

gac aga gtc acc atc act tgc cgg gca agt cag ggc att aga aat gat       96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp         
            20                  25                  30                  

tta ggc tgg tat cag cag aaa cca ggg aaa gcc cct aaa cgc ctg atc      144
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile         
        35                  40                  45                      

tat gct gca tcc agt ttg caa agt ggg gtc cca tca agg ttc agc ggc      192
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly         
    50                  55                  60                          

agt gga tct ggg aca gaa ttc act ctc aca atc agc agc ctg cag cct      240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro         
65                  70                  75                  80          

gaa gat ttt gca act tat tac tgt cta cag cat aat agt tac ccg ctc      288
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu         
                85                  90                  95              

act ttc ggc gga ggg acc aag gtg gag atc aaa                          321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                             
            100                 105                                     


<210>  248
<211>  107
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  248

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  249
<211>  366
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH1 coding sequence


<220>
<221>  CDS
<222>  (1)..(366)

<400>  249
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agt cat tac       96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser His Tyr         
            20                  25                  30                  

tac tgg agc tgg atc cgg cag ccc cca ggg aag gga ctg ggg tgg att      144
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Gly Trp Ile         
        35                  40                  45                      

ggg tat atc tat tac agt ggg agc acc aac tac aac ccc tcc ctc aag      192
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys         
    50                  55                  60                          

agt cga gtc acc ata tca gta gac acg tcc aag aac cag ttc tcc ctg      240
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu         
65                  70                  75                  80          

aag ctg acc tct gtg acc gct gcg gac acg gcc gtg tat tac tgt gcg      288
Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala         
                85                  90                  95              

agg gcc cgg gga gat ggc tac aat tac cct gat gct ttt gat atc tgg      336
Arg Ala Arg Gly Asp Gly Tyr Asn Tyr Pro Asp Ala Phe Asp Ile Trp         
            100                 105                 110                 

ggc caa ggg aca atg gtc acc gtc tct agt                              366
Gly Gln Gly Thr Met Val Thr Val Ser Ser                                 
        115                 120                                         


<210>  250
<211>  122
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  250

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser His Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Gly Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Arg Gly Asp Gly Tyr Asn Tyr Pro Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  251
<211>  354
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH2 coding sequence


<220>
<221>  CDS
<222>  (1)..(354)

<400>  251
cag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg agg       48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt gca gcg tct gga ttc acc ttc agt agc tat       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr         
            20                  25                  30                  

ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg      144
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

gca gtt ata tgg tat gat gga agt aat aaa tac tat gca gac tcc gtg      192
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val         
    50                  55                  60                          

aag ggc cga ttc act atc tcc aga gac aat tcc aag aac acg ctg tat      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ctg caa atg aac agc ctg aga gcc gag gac acg gct gtg tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg agg tat aac tgg aac tac ggt atg gac gtc tgg ggc caa ggg acc      336
Ala Arg Tyr Asn Trp Asn Tyr Gly Met Asp Val Trp Gly Gln Gly Thr         
            100                 105                 110                 

acg gtc acc gtc tct agt                                              354
Thr Val Thr Val Ser Ser                                                 
        115                                                             


<210>  252
<211>  118
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  252

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asn Trp Asn Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  253
<211>  354
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CH3 coding sequence


<220>
<221>  CDS
<222>  (1)..(354)

<400>  253
cag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg agg       48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt gca gcg tct gga ttc acc ttc agt agc tat       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr         
            20                  25                  30                  

ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg      144
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

gca gtt ata tgg tat gat gga agt aat aaa tac tat gca gac tcc gtg      192
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val         
    50                  55                  60                          

aag ggc cga ttc act atc tcc aga gac aat tcc aag aac acg ctg tat      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ctg caa atg aac agc ctg aga gcc gag gac acg gct gtg tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg agg tat aac ttc aac tac ggt atg gac gtc tgg ggc caa ggg acc      336
Ala Arg Tyr Asn Phe Asn Tyr Gly Met Asp Val Trp Gly Gln Gly Thr         
            100                 105                 110                 

acg gtc acc gtc tct agt                                              354
Thr Val Thr Val Ser Ser                                                 
        115                                                             


<210>  254
<211>  118
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  254

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asn Phe Asn Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  255
<211>  354
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH4 coding sequence


<220>
<221>  CDS
<222>  (1)..(354)

<400>  255
cag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg agg       48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt gca gcg tct gga ttc acc ttc agt agc tat       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr         
            20                  25                  30                  

ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg      144
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

gca gtt ata tgg tat gat gga agt aat aaa tac tat gca gac tcc gtg      192
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val         
    50                  55                  60                          

aag ggc cga ttc act atc tcc aga gac aat tcc aag aac acg ctg tat      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ctg caa atg aac agc ctg aga gcc gag gac acg gct gtg tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg agg tat aac tac aac tac ggt atg gac gtc tgg ggc caa ggg acc      336
Ala Arg Tyr Asn Tyr Asn Tyr Gly Met Asp Val Trp Gly Gln Gly Thr         
            100                 105                 110                 

acg gtc acc gtc tct agt                                              354
Thr Val Thr Val Ser Ser                                                 
        115                                                             


<210>  256
<211>  118
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  256

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asn Tyr Asn Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  257
<211>  369
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH5 coding sequence


<220>
<221>  CDS
<222>  (1)..(369)
<223>  VH5 coding sequence

<400>  257
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtt aag cct tcg gag       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agt agt tac       96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr         
            20                  25                  30                  

tac tgg agc tgg atc cgg cag ccc cca ggg aag gga ctg gag tgg att      144
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile         
        35                  40                  45                      

ggg tat atc tat tac agt ggg aac acc aac tcc aac ccc tcc ctc aag      192
Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Ser Asn Pro Ser Leu Lys         
    50                  55                  60                          

agt cga gtc acc ata tca gta gac acg tcc aag aac cag ttc tcc ctg      240
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu         
65                  70                  75                  80          

aag ctg agc tct gtg acc gct gcg gac acg gcc gtg tat tac tgt gcg      288
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala         
                85                  90                  95              

aga acc tac tat gat agt agt ggt tac tac tac cgt gct ttt gat atc      336
Arg Thr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Arg Ala Phe Asp Ile         
            100                 105                 110                 

tgg ggc caa ggg aca atg gtc acc gtc tct agt                          369
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser                             
        115                 120                                         


<210>  258
<211>  123
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  258

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Ser Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Arg Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  259
<211>  366
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH6 coding sequence


<220>
<221>  CDS
<222>  (1)..(366)

<400>  259
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tta cag       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Leu Gln         
1               5                   10                  15              

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc agt ggt       96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly         
            20                  25                  30                  

ggt tat tac tgg agc tgg atc cgc cag cac cca ggg aag ggc ctg gag      144
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu         
        35                  40                  45                      

tgg att ggg tac atc tat tac agt agg agc acc tac tac aac ccg tcc      192
Trp Ile Gly Tyr Ile Tyr Tyr Ser Arg Ser Thr Tyr Tyr Asn Pro Ser         
    50                  55                  60                          

ctc aag agt cga gtt acc ata tca gta gac acg tct aag aac cag ttc      240
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe         
65                  70                  75                  80          

tcc ctg aag ctg agc tct gtg aca gcc gcg gac acg gcc gtg tat tac      288
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr         
                85                  90                  95              

tgt gcg aga acc ggg tat agc agt ggc tgg tac cct ttt gac tac tgg      336
Cys Ala Arg Thr Gly Tyr Ser Ser Gly Trp Tyr Pro Phe Asp Tyr Trp         
            100                 105                 110                 

ggc cag gga acc ctg gtc acc gtc tct agt                              366
Gly Gln Gly Thr Leu Val Thr Val Ser Ser                                 
        115                 120                                         


<210>  260
<211>  122
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  260

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Leu Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Arg Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Gly Tyr Ser Ser Gly Trp Tyr Pro Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  261
<211>  354
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH7 coding sequence


<220>
<221>  CDS
<222>  (1)..(354)

<400>  261
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct ggg ggg       48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt aac tac       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr         
            20                  25                  30                  

gac atg tac tgg gtc cgc caa act aca gga aaa ggt ctg gag tgg gtc      144
Asp Met Tyr Trp Val Arg Gln Thr Thr Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

tca gct att ggt act gct ggt gac aca tac tat cca ggc tcc gtg aag      192
Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys         
    50                  55                  60                          

ggc cga ttc acc atc tcc aga gaa aat gcc aag aac tcc ttg tat ctt      240
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu         
65                  70                  75                  80          

caa atg aac agc ctg aga gcc ggg gac acg gct gtg tat tac tgt gca      288
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala         
                85                  90                  95              

aga gag aag tct agc acc tcg gcc ttt gac tac tgg ggc cag gga acc      336
Arg Glu Lys Ser Ser Thr Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr         
            100                 105                 110                 

ctg gtc acc gtc tcc tca                                              354
Leu Val Thr Val Ser Ser                                                 
        115                                                             


<210>  262
<211>  118
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  262

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Tyr Trp Val Arg Gln Thr Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Lys Ser Ser Thr Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  263
<211>  375
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH8 coding sequence


<220>
<221>  CDS
<222>  (1)..(375)

<400>  263
cag ctg cag ctg caa gag tcg ggc cca gga ctg atg aag cct tcg gag       48
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Met Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

agt tac ttc tgg ggc tgg atc cgc cag ccc cca ggg aag gga ctg gag      144
Ser Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu         
        35                  40                  45                      

tgg att ggg agt atc tat tat agt ggg aac acc ttc tac aac ccg tcc      192
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Asn Thr Phe Tyr Asn Pro Ser         
    50                  55                  60                          

ctc aag agt cga gtc acc ata tcc gtt gac acg tcc aag aac cag ttc      240
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe         
65                  70                  75                  80          

tcc ctg aag ctt aac tct atg acc gcc gca gac acg gct gtg tat ttc      288
Ser Leu Lys Leu Asn Ser Met Thr Ala Ala Asp Thr Ala Val Tyr Phe         
                85                  90                  95              

tgt gcg aga caa ggg ggt ata gca gct cgt acc gga tac tgg tac ttc      336
Cys Ala Arg Gln Gly Gly Ile Ala Ala Arg Thr Gly Tyr Trp Tyr Phe         
            100                 105                 110                 

gat ctc tgg ggc cgt ggc acc acg gtc acc gtc tcc tca                  375
Asp Leu Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser                     
        115                 120                 125                     


<210>  264
<211>  125
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  264

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Met Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Asn Thr Phe Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Asn Ser Met Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gln Gly Gly Ile Ala Ala Arg Thr Gly Tyr Trp Tyr Phe 
            100                 105                 110         


Asp Leu Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  265
<211>  357
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH9 coding sequence


<220>
<221>  CDS
<222>  (1)..(357)

<400>  265
cag gtg cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc       48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala         
1               5                   10                  15              

tca gtg aag gtc tcc tgc aag gct tct gga tac acc ttc acc ggc tac       96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr         
            20                  25                  30                  

cac atg cac tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg      144
His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met         
        35                  40                  45                      

gga tgg atc aac cct aac agt ggt ggc aca aac tat gca cag aag ttt      192
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe         
    50                  55                  60                          

cag ggc agg gtc acc atg acc agg gac acg tcc atc agc aca gcc tac      240
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctg agc agg ctg aga tct gac gac acg gcc gtg tat tac tgt      288
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gat cgt ggg agc tac tac tgg ttc gac ccc tgg ggc cag gga      336
Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe Asp Pro Trp Gly Gln Gly         
            100                 105                 110                 

acc ctg gtc acc gtc tcc tca                                          357
Thr Leu Val Thr Val Ser Ser                                             
        115                                                             


<210>  266
<211>  119
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  266

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  267
<211>  281
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 kappa LC-ShK[1-35, Q16K] fusion protein

<400>  267

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


His Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser 
                245                 250                 255     


Arg Cys Thr Ala Phe Lys Cys Lys His Ser Met Lys Tyr Arg Leu Ser 
            260                 265                 270         


Phe Cys Arg Lys Thr Cys Gly Thr Cys 
        275                 280     


<210>  268
<211>  280
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 kappa LC-ShK[1-35, Q16K] fusion protein

<400>  268

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


His Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg 
                245                 250                 255     


Cys Thr Ala Phe Lys Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe 
            260                 265                 270         


Cys Arg Lys Thr Cys Gly Thr Cys 
        275                 280 


<210>  269
<211>  34
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  269
aacaggggag agtgtggagg aggaggatcc ggag                                 34


<210>  270
<211>  22
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  270
catgcggccg ctcattagca gg                                              22


<210>  271
<211>  26
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Forward primer sequence

<400>  271
ggacactgac atggactgaa ggagta                                          26


<210>  272
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Reverse primer sequence

<400>  272
ctcctgggag ttacccgatt g                                               21


<210>  273
<211>  40
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Reverse primer sequence

<400>  273
gatgggccct tggtggaggc tgaggagacg gtgaccgtgg                           40


<210>  274
<211>  36
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  274
aagctcgagg tcgactagac caccatggac atgagg                               36


<210>  275
<211>  41
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  275
aaccgtttaa acgcggccgc tcaacactct cccctgttga a                         41


<210>  276
<211>  41
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  276
aagctcgagg tcgactagac caccatggaa ttgggactga g                         41


<210>  277
<211>  41
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  277
aaccgtttaa acgcggccgc tcatttaccc ggagacaggg a                         41


<210>  278
<211>  37
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  278
ttttttttgc gcgctgtgac atccagatga cccagtc                              37


<210>  279
<211>  32
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  279
aaaaaacgta cgtttgatat ccactttggt cc                                   32


<210>  280
<211>  50
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  280
ctgtgtatta ctgtgcgagg tataacttca actacggtat ggacgtctgg                50


<210>  281
<211>  50
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  281
ccagacgtcc ataccgtagt tgaagttata cctcgcacag taatacacag                50


<210>  282
<211>  50
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  282
ctgtgtatta ctgtgcgagg tataactaca actacggtat ggacgtctgg                50


<210>  283
<211>  50
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  283
ccagacgtcc ataccgtagt tgtagttata cctcgcacag taatacacag                50


<210>  284
<211>  59
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  284
aagctcgagg tcgactagac caccatggac atgagggtgc ccgctcagct cctggggct      59


<210>  285
<211>  41
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  285
aaccgtttaa acgcggccgc tcatttaccc ggagacaggg a                         41


<210>  286
<211>  50
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  286
ggacaagaca gttgagcgca aatcttctgt cgagtgccca ccgtgcccag                50


<210>  287
<211>  50
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  287
ctgggcacgg tgggcactcg acagaagatt tgcgctcaac tgtcttgtcc                50


<210>  288
<211>  59
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  288
aagctcgagg tcgactagac caccatggac atgagggtgc ccgctcagct cctggggct      59


<210>  289
<211>  41
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  289
aaccgtttaa acgcggccgc tcatttaccc ggagacaggg a                         41


<210>  290
<211>  31
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  290

His Gly Glu Gly Thr Phe Thr Ser Asp Gln Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  291
<211>  31
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  291

His Gly Glu Gly Thr Phe Thr Ser Asp Gln Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Gln Lys Gly Arg Gly 
            20                  25                  30      


<210>  292
<211>  31
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  292

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Gln Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  293
<211>  31
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  293

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Gln Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  294
<211>  31
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  294

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Gln Leu Gln Lys Gly Arg Gly 
            20                  25                  30      


<210>  295
<211>  31
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  295

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Gln Lys Gly Arg Gly 
            20                  25                  30      


<210>  296
<211>  31
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  296

His Asn Glu Thr Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  297
<211>  31
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  297

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Asn 
1               5                   10                  15      


Gln Thr Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  298
<211>  31
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  298

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Asn Ala Thr Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  299
<211>  31
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  299

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Asn Gly Thr Gly 
            20                  25                  30      


<210>  300
<211>  31
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  300

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Asn Arg Thr 
            20                  25                  30      


<210>  301
<211>  33
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  301

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Asn Gly 
            20                  25                  30          


Thr 
    


<210>  302
<211>  37
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  302

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          


Thr Gly Asn Gly Thr 
        35          


<210>  303
<211>  37
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  GLP-1 mimetic polypeptide sequence

<400>  303

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          


Ser Gly Asn Gly Thr 
        35          


<210>  304
<211>  511
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 IgG2-ShK[1-35, R1A, I4A, Q16K] fusion protein

<400>  304

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Cys Ala 
465                 470                 475                 480 


Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser 
                485                 490                 495     


Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
            500                 505                 510     


<210>  305
<211>  511
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 IgG2-ShK[1-35, R1A, Q16K, K30E] fusion protein

<400>  305

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Cys Ile 
465                 470                 475                 480 


Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser 
                485                 490                 495     


Met Lys Tyr Arg Leu Ser Phe Cys Arg Glu Thr Cys Gly Thr Cys 
            500                 505                 510     


<210>  306
<211>  511
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 HC IgG2 -ShK[1-35, R1H, I4A, Q16K] fusion protein

<400>  306

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Ser Cys Ala 
465                 470                 475                 480 


Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser 
                485                 490                 495     


Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
            500                 505                 510     


<210>  307
<211>  511
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 IgG2-ShK[1-35, R1H, Q16K, K30E] fusion protein

<400>  307

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Ser Cys Ile 
465                 470                 475                 480 


Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser 
                485                 490                 495     


Met Lys Tyr Arg Leu Ser Phe Cys Arg Glu Thr Cys Gly Thr Cys 
            500                 505                 510     


<210>  308
<211>  511
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 HC (IgG2)-ShK[1-35, R1K, I4A, Q16K] fusion protein

<400>  308

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ser Cys Ala 
465                 470                 475                 480 


Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser 
                485                 490                 495     


Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys Gly Thr Cys 
            500                 505                 510     


<210>  309
<211>  511
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 IgG2-ShK[1-35, R1K, Q16K, K30E] fusion protein

<400>  309

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ser Cys Ile 
465                 470                 475                 480 


Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys Cys Lys His Ser 
                485                 490                 495     


Met Lys Tyr Arg Leu Ser Phe Cys Arg Glu Thr Cys Gly Thr Cys 
            500                 505                 510     


<210>  310
<211>  37
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  310
aggaggagga agcgccagct gcgccgacac catcccc                              37


<210>  311
<211>  37
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  311
ggggatggtg tcggcgcagc tggcgcttcc tcctcct                              37


<210>  312
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  312
gaggaggagg aagcgccagc tgcatcgaca                                      30


<210>  313
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  313
gagcttctgc cgcgagacct gcggcac                                         27


<210>  314
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  314
cgatgcagct ggcgcttcct cctcctc                                         27


<210>  315
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  315
gtgccgcagg tctcgcggca gaagctc                                         27


<210>  316
<211>  36
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  316
ggaggaggaa gccacagctg cgccgacacc atcccc                               36


<210>  317
<211>  36
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  317
ggggatggtg tcggcgcagc tgtggcttcc tcctcc                               36


<210>  318
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  318
ggaggaggaa gccacagctg catcgac                                         27


<210>  319
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  319
gtcgatgcag ctgtggcttc ctcctcc                                         27


<210>  320
<211>  45
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  320
ccggaggagg aggaagcaag agctgcgccg acaccatccc caaga                     45


<210>  321
<211>  45
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  321
tcttggggat ggtgtcggcg cagctcttgc ttcctcctcc tccgg                     45


<210>  322
<211>  35
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  322
cggaggagga ggaagcaaga gctgcatcga cacca                                35


<210>  323
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  323
tggtgtcgat gcagctcttg cttcctcctc ctc                                  33


<210>  324
<211>  493
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 IgG2 HC-Amp5 fusion protein

<400>  324

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Trp Tyr Val Asp Gly Val Glu Val His 
                245                 250                 255     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
            260                 265                 270         


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
        275                 280                 285             


Glu Tyr Lys Cys Lys Val Ser Pro Pro Cys Pro Ala Pro Pro Val Ala 
    290                 295                 300                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Gln Phe Asn Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Gly Gln Gly Cys Ser Ser Gly Gly Pro Thr 
465                 470                 475                 480 


Leu Arg Glu Trp Gln Gln Cys Arg Arg Ala Gln His Ser 
                485                 490             


<210>  325
<211>  59
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Forward primer sequence

<400>  325
aagctcgagg tcgactagac caccatggac atgagggtgc ccgctcagct cctggggct      59


<210>  326
<211>  51
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Reverse primer sequence

<400>  326
gccgctgctg cagccctgac caccacctcc accacccgga gacagggaga g              51


<210>  327
<211>  474
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VK1sp-KLH-120.6 IgG2 HC DesK-G5 fusion fragment

<400>  327

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Gly Gln Gly Cys 
465                 470                 


<210>  328
<211>  51
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Forward primer sequence

<400>  328
ctctccctgt ctccgggtgg tggaggtggt ggtcagggct gcagcagcgg c              51


<210>  329
<211>  35
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Reverse primer sequence

<400>  329
ctactagcgg ccgctcagct atgctgagcg cggcg                                35


<210>  330
<211>  33
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  G5-AMP5 fusion fragment

<400>  330

Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Gly Gln Gly Cys Ser Ser 
1               5                   10                  15      


Gly Gly Pro Thr Leu Arg Glu Trp Gln Gln Cys Arg Arg Ala Gln His 
            20                  25                  30          


Ser 
    


<210>  331
<211>  493
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  IgG2 DesK HC-AMP5 fusion polypeptide

<400>  331

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Gly Gln Gly Cys Ser Ser Gly Gly Pro Thr 
465                 470                 475                 480 


Leu Arg Glu Trp Gln Gln Cys Arg Arg Ala Gln His Ser 
                485                 490             


<210>  332
<211>  497
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  AMP5-aKLH120.6-IgG2 Heavy Chain(HC)

<400>  332

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Gly Cys Ser Ser Gly Gly Pro Thr Leu 
            20                  25                  30          


Arg Glu Trp Gln Gln Cys Arg Arg Ala Gln His Ser Gly Gly Gly Gly 
        35                  40                  45              


Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    50                  55                  60                  


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly 
65                  70                  75                  80  


Tyr His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                85                  90                  95      


Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys 
            100                 105                 110         


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala 
        115                 120                 125             


Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr 
    130                 135                 140                 


Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe Asp Pro Trp Gly Gln 
145                 150                 155                 160 


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                165                 170                 175     


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
            180                 185                 190         


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
        195                 200                 205             


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
    210                 215                 220                 


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
225                 230                 235                 240 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
                245                 250                 255     


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  333
<211>  38
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Reverse primer sequence

<400>  333
gccgctgctg cagccctgac atctggcacc tctcaacc                             38


<210>  334
<211>  28
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PCR-generated fusion peptide

<400>  334

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Gly Cys Ser Ser Gly 
            20                  25              


<210>  335
<211>  38
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Reverse primer sequence

<400>  335
ggttgagagg tgccagatgt cagggctgca gcagcggc                             38


<210>  336
<211>  42
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Reverse primer sequence

<400>  336
cagctgcacc tgaccaccac ctccaccgct atgctgagcg cg                        42


<210>  337
<211>  39
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fusion polypeptide sequence

<400>  337

Trp Leu Arg Gly Ala Arg Cys Gln Gly Cys Ser Ser Gly Gly Pro Thr 
1               5                   10                  15      


Leu Arg Glu Trp Gln Gln Cys Arg Arg Ala Gln His Ser Gly Gly Gly 
            20                  25                  30          


Gly Gly Gln Val Gln Leu Val 
        35                  


<210>  338
<211>  42
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Forward primer sequence

<400>  338
cgcgctcagc atagcggtgg aggtggtggt caggtgcagc tg                        42


<210>  339
<211>  34
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Reverse primer sequence

<400>  339
ctactagcgg ccgctcaacc cggagacagg gaga                                 34


<210>  340
<211>  458
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fusion polypeptide sequence

<400>  340

Arg Ala Gln His Ser Gly Gly Gly Gly Gly Gln Val Gln Leu Val Gln 
1               5                   10                  15      


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
            20                  25                  30          


Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn 
    50                  55                  60                  


Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met 
65                  70                  75                  80  


Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu 
                85                  90                  95      


Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser 
            100                 105                 110         


Tyr Tyr Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455             


<210>  341
<211>  496
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 hIgG1 N297Q-Amp5 Fc(CH3) Loop fusion

<400>  341

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Gly Gly 
    370                 375                 380                 


Gln Gly Cys Ser Ser Gly Gly Pro Thr Leu Arg Glu Trp Gln Gln Cys 
385                 390                 395                 400 


Arg Arg Ala Gln His Ser Gly Gly Thr Lys Asn Gln Val Ser Leu Thr 
                405                 410                 415     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            420                 425                 430         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
465                 470                 475                 480 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 495     


<210>  342
<211>  263
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Amp5-KLH-120.6 kappa LC fusion protein

<400>  342

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Gly Cys Ser Ser Gly Gly Pro Thr Leu 
            20                  25                  30          


Arg Glu Trp Gln Gln Cys Arg Arg Ala Gln His Ser Gly Gly Gly Gly 
        35                  40                  45              


Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
    50                  55                  60                  


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn 
65                  70                  75                  80  


Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu 
                85                  90                  95      


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
            100                 105                 110         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
        115                 120                 125             


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro 
    130                 135                 140                 


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
145                 150                 155                 160 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                165                 170                 175     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            180                 185                 190         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        195                 200                 205             


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    210                 215                 220                 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
225                 230                 235                 240 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                245                 250                 255     


Ser Phe Asn Arg Gly Glu Cys 
            260             


<210>  343
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  343
cattctagaa ccaccatgga catgagggtg                                      30


<210>  344
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  344
ctgggtcatc tggatgtcac caccacctcc accgctatgc tgagcgcg                  48


<210>  345
<211>  40
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fusion peptide sequence

<400>  345

Trp Leu Arg Gly Ala Arg Cys Gln Gly Cys Ser Ser Gly Gly Pro Thr 
1               5                   10                  15      


Leu Arg Glu Trp Gln Gln Cys Arg Arg Ala Gln His Ser Gly Gly Gly 
            20                  25                  30          


Gly Gly Asp Ile Gln Met Thr Gln 
        35                  40  


<210>  346
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Forward primer sequence

<400>  346
cgcgctcagc atagcggtgg aggtggtggt gacatccaga tgacccag                  48


<210>  347
<211>  41
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Reverse primer sequence

<400>  347
aaccgtttaa acgcggccgc tcaacactct cccctgttga a                         41


<210>  348
<211>  224
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fusion peptide sequence

<400>  348

Arg Ala Gln His Ser Gly Gly Gly Gly Gly Asp Ile Gln Met Thr Gln 
1               5                   10                  15      


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
            20                  25                  30          


Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln 
        35                  40                  45              


Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu 
    50                  55                  60                  


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
65                  70                  75                  80  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
            100                 105                 110         


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
        115                 120                 125             


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
    130                 135                 140                 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
145                 150                 155                 160 


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
                165                 170                 175     


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
            180                 185                 190         


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
        195                 200                 205             


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220                 


<210>  349
<211>  39
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Exendin 4 polypeptide

<400>  349

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  350
<211>  273
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  (VK-1 SP)-C681-KLH-120.6 IgG2 variable HC fusion polypeptide

<400>  350

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Gly Gly Ser Cys Leu Pro Asp Gln Phe 
            20                  25                  30          


Arg Cys Gly Asn Gly Gln Cys Ile Pro Leu Asp Trp Val Cys Asp Gly 
        35                  40                  45              


Val Asn Asp Cys Pro Asp Asp Ser Asp Glu Glu Gly Cys Pro Pro Arg 
    50                  55                  60                  


Thr Cys Ala Pro Ser Gln Phe Gln Cys Gly Ser Gly Tyr Cys Ile Ser 
65                  70                  75                  80  


Gln Arg Trp Val Cys Asp Gly Glu Asn Asp Cys Glu Asp Gly Ser Asp 
                85                  90                  95      


Glu Ala Asn Cys Ala Gly Ser Val Pro Thr Cys Pro Ser Asp Glu Phe 
            100                 105                 110         


Arg Cys Arg Asn Gly Arg Cys Ile Pro Arg Ala Trp Arg Cys Asp Gly 
        115                 120                 125             


Val Asn Asp Cys Ala Asp Asn Ser Asp Glu Glu Asp Cys Thr Glu His 
    130                 135                 140                 


Thr Gly Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
        195                 200                 205             


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
                245                 250                 255     


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            260                 265                 270         


Lys 
    


<210>  351
<211>  267
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SalI (5') and BamHI (3')DNA Fragment

<400>  351
gtcgactaga ccaccatgga catgagggtc cccgctcagc tcctggggct cctgctattg     60

tggttgagag gtgccagatg tcatggggag ggaacattta caagcgatct gagcaaacaa    120

atggaggaag aggcagttag actgttcatt gaatggctca agaacggcgg accgagtagt    180

ggtgctccgc ctcccagcgg atctggcagc gctactggtg gatctggatc gggtgcatcc    240

tctggatctg gaagcgctac cggatcc                                        267


<210>  352
<211>  29
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  352
aatggatccg acatccagat gacccagtc                                       29


<210>  353
<211>  23
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer sequence

<400>  353
aatgcggccg ctcaacactc tcc                                             23


<210>  354
<211>  920
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Ex-4-1kG-KLH-120.6 kappa LC coding sequence construct

<400>  354
gtcgactaga ccaccatgga catgagggtc cccgctcagc tcctggggct cctgctattg     60

tggttgagag gtgccagatg tcatggggag ggaacattta caagcgatct gagcaaacaa    120

atggaggaag aggcagttag actgttcatt gaatggctca agaacggcgg accgagtagt    180

ggtgctccgc ctcccagcgg atctggcagc gctactggtg gatctggatc gggtgcatcc    240

tctggatctg gaagcgctac cggatccgac atccagatga cccagtctcc atcctccctg    300

tctgcatctg taggagacag agtcaccatc acttgccggg caagtcaggg cattagaaat    360

gatttaggct ggtatcagca gaaaccaggg aaagccccta aacgcctgat ctatgctgca    420

tccagtttgc aaagtggggt cccatcaagg ttcagcggca gtggatctgg gacagaattc    480

actctcacaa tcagcagcct gcagcctgaa gattttgcaa cttattactg tctacagcat    540

aatagttacc cgctcacttt cggcggaggg accaaggtgg agatcaaacg aactgtggct    600

gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct    660

gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat    720

aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag caaggacagc    780

acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa acacaaagtc    840

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg    900

ggagagtgtt gagcggccgc                                                920


<210>  355
<211>  298
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  (VK-1 SP)-Ex-4-1kG-KLH-120.6 kappa LC

<400>  355

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
            20                  25                  30          


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
        35                  40                  45              


Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Ser Gly 
    50                  55                  60                  


Ser Ala Thr Gly Gly Ser Gly Ser Gly Ala Ser Ser Gly Ser Gly Ser 
65                  70                  75                  80  


Ala Thr Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
                85                  90                  95      


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
            100                 105                 110         


Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        115                 120                 125             


Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
    130                 135                 140                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
145                 150                 155                 160 


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn 
                165                 170                 175     


Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            180                 185                 190         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        195                 200                 205             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    210                 215                 220                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
225                 230                 235                 240 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                245                 250                 255     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            260                 265                 270         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        275                 280                 285             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    290                 295             


<210>  356
<211>  594
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  (VK-1 SP)-C681-aKLH 120.6 IgG2 HC fusion

<400>  356

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Gly Gly Ser Cys Leu Pro Asp Gln Phe 
            20                  25                  30          


Arg Cys Gly Asn Gly Gln Cys Ile Pro Leu Asp Trp Val Cys Asp Gly 
        35                  40                  45              


Val Asn Asp Cys Pro Asp Asp Ser Asp Glu Glu Gly Cys Pro Pro Arg 
    50                  55                  60                  


Thr Cys Ala Pro Ser Gln Phe Gln Cys Gly Ser Gly Tyr Cys Ile Ser 
65                  70                  75                  80  


Gln Arg Trp Val Cys Asp Gly Glu Asn Asp Cys Glu Asp Gly Ser Asp 
                85                  90                  95      


Glu Ala Asn Cys Ala Gly Ser Val Pro Thr Cys Pro Ser Asp Glu Phe 
            100                 105                 110         


Arg Cys Arg Asn Gly Arg Cys Ile Pro Arg Ala Trp Arg Cys Asp Gly 
        115                 120                 125             


Val Asn Asp Cys Ala Asp Asn Ser Asp Glu Glu Asp Cys Thr Glu His 
    130                 135                 140                 


Thr Gly Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
        195                 200                 205             


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
                245                 250                 255     


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            260                 265                 270         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
        275                 280                 285             


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    290                 295                 300                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
305                 310                 315                 320 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                325                 330                 335     


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
            340                 345                 350         


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
        355                 360                 365             


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
    370                 375                 380                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
385                 390                 395                 400 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                405                 410                 415     


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            420                 425                 430         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
        435                 440                 445             


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
    450                 455                 460                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
465                 470                 475                 480 


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
                485                 490                 495     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            500                 505                 510         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        515                 520                 525             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    530                 535                 540                 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
545                 550                 555                 560 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                565                 570                 575     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            580                 585                 590         


Pro Gly 
        


<210>  357
<211>  594
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  aKLH 120.6 IgG2 HC-C681 fusion polypeptide

<400>  357

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Gly Gly Gly Gly Gly Ser Gly Gly Ser Cys Leu Pro Asp Gln 
465                 470                 475                 480 


Phe Arg Cys Gly Asn Gly Gln Cys Ile Pro Leu Asp Trp Val Cys Asp 
                485                 490                 495     


Gly Val Asn Asp Cys Pro Asp Asp Ser Asp Glu Glu Gly Cys Pro Pro 
            500                 505                 510         


Arg Thr Cys Ala Pro Ser Gln Phe Gln Cys Gly Ser Gly Tyr Cys Ile 
        515                 520                 525             


Ser Gln Arg Trp Val Cys Asp Gly Glu Asn Asp Cys Glu Asp Gly Ser 
    530                 535                 540                 


Asp Glu Ala Asn Cys Ala Gly Ser Val Pro Thr Cys Pro Ser Asp Glu 
545                 550                 555                 560 


Phe Arg Cys Arg Asn Gly Arg Cys Ile Pro Arg Ala Trp Arg Cys Asp 
                565                 570                 575     


Gly Val Asn Asp Cys Ala Asp Asn Ser Asp Glu Glu Asp Cys Thr Glu 
            580                 585                 590         


His Thr 
        


<210>  358
<211>  217
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  C681 avimer polypeptide sequence

<400>  358

Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
1               5                   10                  15      


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            20                  25                  30          


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
        35                  40                  45              


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    50                  55                  60                  


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
65                  70                  75                  80  


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Ser Cys Leu Pro Asp Gln Phe Arg Cys Gly Asn Gly Gln Cys Ile 
            100                 105                 110         


Pro Leu Asp Trp Val Cys Asp Gly Val Asn Asp Cys Pro Asp Asp Ser 
        115                 120                 125             


Asp Glu Glu Gly Cys Pro Pro Arg Thr Cys Ala Pro Ser Gln Phe Gln 
    130                 135                 140                 


Cys Gly Ser Gly Tyr Cys Ile Ser Gln Arg Trp Val Cys Asp Gly Glu 
145                 150                 155                 160 


Asn Asp Cys Glu Asp Gly Ser Asp Glu Ala Asn Cys Ala Gly Ser Val 
                165                 170                 175     


Pro Thr Cys Pro Ser Asp Glu Phe Arg Cys Arg Asn Gly Arg Cys Ile 
            180                 185                 190         


Pro Arg Ala Trp Arg Cys Asp Gly Val Asn Asp Cys Ala Asp Asn Ser 
        195                 200                 205             


Asp Glu Glu Asp Cys Thr Glu His Thr 
    210                 215         


<210>  359
<211>  364
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  C681-aKLH 120.6 kappa LC fusion

<400>  359

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Gly Gly Ser Cys Leu Pro Asp Gln Phe 
            20                  25                  30          


Arg Cys Gly Asn Gly Gln Cys Ile Pro Leu Asp Trp Val Cys Asp Gly 
        35                  40                  45              


Val Asn Asp Cys Pro Asp Asp Ser Asp Glu Glu Gly Cys Pro Pro Arg 
    50                  55                  60                  


Thr Cys Ala Pro Ser Gln Phe Gln Cys Gly Ser Gly Tyr Cys Ile Ser 
65                  70                  75                  80  


Gln Arg Trp Val Cys Asp Gly Glu Asn Asp Cys Glu Asp Gly Ser Asp 
                85                  90                  95      


Glu Ala Asn Cys Ala Gly Ser Val Pro Thr Cys Pro Ser Asp Glu Phe 
            100                 105                 110         


Arg Cys Arg Asn Gly Arg Cys Ile Pro Arg Ala Trp Arg Cys Asp Gly 
        115                 120                 125             


Val Asn Asp Cys Ala Asp Asn Ser Asp Glu Glu Asp Cys Thr Glu His 
    130                 135                 140                 


Thr Gly Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                165                 170                 175     


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
            180                 185                 190         


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
        195                 200                 205             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
225                 230                 235                 240 


His Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
            260                 265                 270         


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
        275                 280                 285             


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
    290                 295                 300                 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
305                 310                 315                 320 


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
                325                 330                 335     


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
            340                 345                 350         


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360                 


<210>  360
<211>  261
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  (VK-1 SP)-C681-(G5)-aKLH 120.6 kappa variable LC fusion 
       polypeptide

<400>  360

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Gly Gly Ser Cys Leu Pro Asp Gln Phe 
            20                  25                  30          


Arg Cys Gly Asn Gly Gln Cys Ile Pro Leu Asp Trp Val Cys Asp Gly 
        35                  40                  45              


Val Asn Asp Cys Pro Asp Asp Ser Asp Glu Glu Gly Cys Pro Pro Arg 
    50                  55                  60                  


Thr Cys Ala Pro Ser Gln Phe Gln Cys Gly Ser Gly Tyr Cys Ile Ser 
65                  70                  75                  80  


Gln Arg Trp Val Cys Asp Gly Glu Asn Asp Cys Glu Asp Gly Ser Asp 
                85                  90                  95      


Glu Ala Asn Cys Ala Gly Ser Val Pro Thr Cys Pro Ser Asp Glu Phe 
            100                 105                 110         


Arg Cys Arg Asn Gly Arg Cys Ile Pro Arg Ala Trp Arg Cys Asp Gly 
        115                 120                 125             


Val Asn Asp Cys Ala Asp Asn Ser Asp Glu Glu Asp Cys Thr Glu His 
    130                 135                 140                 


Thr Gly Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                165                 170                 175     


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
            180                 185                 190         


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
        195                 200                 205             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
225                 230                 235                 240 


His Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys Arg Thr Val Ala 
            260     


<210>  361
<211>  35
<212>  PRT
<213>  Stichodactyla helianthus

<400>  361

Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Gln 
1               5                   10                  15      


Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys 
            20                  25                  30          


Gly Thr Cys 
        35  


<210>  362
<211>  36
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  [Lys16]ShK-Ala

<400>  362

Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys 
1               5                   10                  15      


Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys 
            20                  25                  30          


Gly Thr Cys Ala 
        35      


<210>  363
<211>  35
<212>  PRT
<213>  Stichodactyla helianthus


<220>
<221>  MISC_FEATURE
<223>  PEGylated

<400>  363

Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Gln 
1               5                   10                  15      


Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys 
            20                  25                  30          


Gly Thr Cys 
        35  


<210>  364
<211>  35
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ShK PEGylated toxin peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  PEGylated

<400>  364

Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys 
1               5                   10                  15      


Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys 
            20                  25                  30          


Gly Thr Cys 
        35  


<210>  365
<211>  36
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PEGylated toxin peptide analog


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  20kDa PEG-[Lys16]ShK-Ala

<400>  365

Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys 
1               5                   10                  15      


Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys 
            20                  25                  30          


Gly Thr Cys Ala 
        35      


<210>  366
<211>  463
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  H23 sequence

<400>  366

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe Asp Pro Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
225                 230                 235                 240 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460             


<210>  367
<211>  467
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  H24 sequence

<400>  367

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Tyr Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  368
<211>  659
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BamHI (5') to NotI (3') DNA fragment

<400>  368
ggatccgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga     60

gtcaccatca cttgccgggc aagtcagggc attagaaatg atttaggctg gtatcagcag    120

aaaccaggga aagcccctaa acgcctgatc tatgctgcat ccagtttgca aagtggggtc    180

ccatcaaggt tcagcggcag tggatctggg acagaattca ctctcacaat cagcagcctg    240

cagcctgaag attttgcaac ttattactgt ctacagcata atagttaccc gctcactttc    300

ggcggaggga ccaaggtgga gatcaaacga actgtggctg caccatctgt cttcatcttc    360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgttg agcggccgc     659


