                         SEQUENCE LISTING

<110>  Shah, Jyoti
       Strapps, Walter
      Pickering, Victoria
 
<120>  RNA Interference Mediated Inhibition of Connective Tissue Growth 
       Factor (CTGF) Gene Expression Using Short Interfering Nucleic 
       Acid (siNA)

<130>  SIRMIS76WPCT

<160>  148   

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  1
ccuaucaagu uugagcuuu                                                    19


<210>  2
<211>  19
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<400>  2
gaguggagcg ccuguucca                                                    19


<210>  3
<211>  19
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<400>  3
gauucccacc caauucaaa                                                    19


<210>  4
<211>  19
<212>  RNA
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<400>  4
gacauuaacu cauuagacu                                                    19


<210>  5
<211>  19
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<400>  5
gacauaccga gcuaaauuc                                                    19


<210>  6
<211>  19
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<400>  6
gugugcaccg ccaaagaug                                                    19


<210>  7
<211>  19
<212>  RNA
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<400>  7
cugacggcga ggucaugaa                                                    19


<210>  8
<211>  19
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cacagcacca gaauguaua                                                    19


<210>  9
<211>  19
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<400>  9
cgaguaauau gccugcuau                                                    19


<210>  10
<211>  19
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<400>  10
gauagcaucu uauacgagu                                                    19


<210>  11
<211>  19
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<400>  11
cgugugcacc gccaaagau                                                    19


<210>  12
<211>  19
<212>  RNA
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<400>  12
cugccugguc cagaccaca                                                    19


<210>  13
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  13
ggguguguga cgagcccaa                                                    19


<210>  14
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  14
gcgaggucau gaagaagaa                                                    19


<210>  15
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  15
cagagaguga gagacauua                                                    19


<210>  16
<211>  19
<212>  RNA
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<400>  16
gacuugacag uggaacuac                                                    19


<210>  17
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  17
caaguuauuu aaaucuguu                                                    19


<210>  18
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  18
cugugccugc cauuacaac                                                    19


<210>  19
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  19
cuauuugaag uguaauuga                                                    19


<210>  20
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  20
caguggaacu acauuagua                                                    19


<210>  21
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  21
acgaacucau uagacuaua                                                    19


<210>  22
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  22
ucugucaacc ucagacacu                                                    19


<210>  23
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  23
acucauuaga cuauaacuu                                                    19


<210>  24
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  24
ccacucugcc aguggaguu                                                    19


<210>  25
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  25
acacgaacuc auuagacua                                                    19


<210>  26
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  26
aguggagaug ccaggagaa                                                    19


<210>  27
<211>  19
<212>  RNA
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<400>  27
gccugucaag uuugagcuu                                                    19


<210>  28
<211>  19
<212>  RNA
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<400>  28
acaguuuaca cuugacagu                                                    19


<210>  29
<211>  19
<212>  RNA
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<400>  29
gggucaagcu gccugggaa                                                    19


<210>  30
<211>  19
<212>  RNA
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<223>  Synthetic

<400>  30
ugguuucgag acaguuuac                                                    19


<210>  31
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
agugcauccg gacaccuaa                                                    19


<210>  32
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
acugguuucg agacaguuu                                                    19


<210>  33
<211>  19
<212>  RNA
<213>  Artificial Sequence

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<223>  Synthetic

<400>  33
ccaacuauga ugcgagcca                                                    19


<210>  34
<211>  19
<212>  RNA
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<220>
<223>  Synthetic

<400>  34
agugugcacu gccaaagau                                                    19


<210>  35
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
ggagacaugg cguaaagcc                                                    19


<210>  36
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
ggaggaacua ucccaccaa                                                    19


<210>  37
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
ccucagacac ugguuucga                                                    19


<210>  38
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
acaguagcac auuaauuua                                                    19


<210>  39
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
aggaaguaag ggacacgaa                                                    19


<210>  40
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
gguacuagcu gagguuauu                                                    19


<210>  41
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
ucaagaccug ugccugcca                                                    19


<210>  42
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
aggaagaugu acggagaca                                                    19


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
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<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  43
aggaagaugu acggagacat t                                                 21


<210>  44
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
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<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
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<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  2'-O-methyl

<400>  44
aaagcucaaa cuugauaggu u                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
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<220>
<221>  misc_feature
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<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  45
gaguggagcg ccuguuccat t                                                 21


<210>  46
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
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<220>
<221>  misc_feature
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<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  46
uggaacaggc gcuccacucu u                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
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<220>
<221>  misc_feature
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<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
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<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
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<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  47
gauucccacc caauucaaat t                                                 21


<210>  48
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  48
uuugaauugg gugggaaucu u                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
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<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
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<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  49
gacauuaacu cauuagacut t                                                 21


<210>  50
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  50
agucuaauga guuaaugucu u                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<400>  51
gacauaccga gcuaaauuct t                                                 21


<210>  52
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  52
gaauuuagcu cgguaugucu u                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  53
gugugcaccg ccaaagaugt t                                                 21


<210>  54
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  54
caucuuuggc ggugcacacu u                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  55
cugacggcga ggucaugaat t                                                 21


<210>  56
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  56
uucaugaccu cgccgucagu u                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  57
cacagcacca gaauguauat t                                                 21


<210>  58
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  58
uauacauucu ggugcugugu u                                                 21


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  59
cgaguaauau gccugcuaut t                                                 21


<210>  60
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  60
auagcaggca uauuacucgu u                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  61
gauagcaucu uauacgagut t                                                 21


<210>  62
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  62
acucguauaa gaugcuaucu u                                                 21


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  63
cgugugcacc gccaaagaut t                                                 21


<210>  64
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  64
aucuuuggcg gugcacacgu u                                                 21


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  65
cugccugguc cagaccacat t                                                 21


<210>  66
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  66
uguggucugg accaggcagu u                                                 21


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  67
ggguguguga cgagcccaat t                                                 21


<210>  68
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  68
uugggcucgu cacacacccu u                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  69
gcgaggucau gaagaagaat t                                                 21


<210>  70
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  70
uucuucuuca ugaccucgcu u                                                 21


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  71
cagagaguga gagacauuat t                                                 21


<210>  72
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  72
uaaugucucu cacucucugu u                                                 21


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(19)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  73
gacuugacag uggaacuact t                                                 21


<210>  74
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  74
guaguuccac ugucaagucu u                                                 21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  75
caaguuauuu aaaucuguut t                                                 21


<210>  76
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  76
aacagauuua aauaacuugu u                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  77
cugugccugc cauuacaact t                                                 21


<210>  78
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  78
guuguaaugg caggcacagu u                                                 21


<210>  79
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  79
cuauuugaag uguaauugat t                                                 21


<210>  80
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  80
ucaauuacac uucaaauagu u                                                 21


<210>  81
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  81
caguggaacu acauuaguat t                                                 21


<210>  82
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  82
uacuaaugua guuccacugu u                                                 21


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  83
acgaacucau uagacuauat t                                                 21


<210>  84
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  84
uauagucuaa ugaguucguu u                                                 21


<210>  85
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  85
ucugucaacc ucagacacut t                                                 21


<210>  86
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  2'-O-methyl

<400>  86
agugucugag guugacagau u                                                 21


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  87
acucauuaga cuauaacuut t                                                 21


<210>  88
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  88
aaguuauagu cuaaugaguu u                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  89
ccacucugcc aguggaguut t                                                 21


<210>  90
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  90
aacuccacug gcagaguggu u                                                 21


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  91
acacgaacuc auuagacuat t                                                 21


<210>  92
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  92
uagucuaaug aguucguguu u                                                 21


<210>  93
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  93
aguggagaug ccaggagaat t                                                 21


<210>  94
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  94
uucuccuggc aucuccacuu u                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  95
gccugucaag uuugagcuut t                                                 21


<210>  96
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  96
aagcucaaac uugacaggcu u                                                 21


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  97
acaguuuaca cuugacagut t                                                 21


<210>  98
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  98
acugucaagu guaaacuguu u                                                 21


<210>  99
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  99
gggucaagcu gccugggaat t                                                 21


<210>  100
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  100
uucccaggca gcuugacccu u                                                 21


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  101
ugguuucgag acaguuuact t                                                 21


<210>  102
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  102
guaaacuguc ucgaaaccau u                                                 21


<210>  103
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  103
agugcauccg gacaccuaat t                                                 21


<210>  104
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  104
uuaggugucc ggaugcacuu u                                                 21


<210>  105
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  105
acugguuucg agacaguuut t                                                 21


<210>  106
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  106
aaacugucuc gaaaccaguu u                                                 21


<210>  107
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  107
ccaacuauga ugcgagccat t                                                 21


<210>  108
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  108
uggcucgcau cauaguuggu u                                                 21


<210>  109
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  109
agugugcacu gccaaagaut t                                                 21


<210>  110
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  110
aucuuuggca gugcacacuu u                                                 21


<210>  111
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  111
ggagacaugg cguaaagcct t                                                 21


<210>  112
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  112
ggcuuuacgc caugucuccu u                                                 21


<210>  113
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  113
ggaggaacua ucccaccaat t                                                 21


<210>  114
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  114
uuggugggau aguuccuccu u                                                 21


<210>  115
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  115
ccucagacac ugguuucgat t                                                 21


<210>  116
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  2'-O-methyl

<400>  116
ucgaaaccag ugucugaggu u                                                 21


<210>  117
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  117
acaguagcac auuaauuuat t                                                 21


<210>  118
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  118
uaaauuaaug ugcuacuguu u                                                 21


<210>  119
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  119
aggaaguaag ggacacgaat t                                                 21


<210>  120
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  120
uucguguccc uuacuuccuu u                                                 21


<210>  121
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  121
gguacuagcu gagguuauut t                                                 21


<210>  122
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  122
aauaaccuca gcuaguaccu u                                                 21


<210>  123
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  123
ucaagaccug ugccugccat t                                                 21


<210>  124
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  124
uggcaggcac aggucuugau u                                                 21


<210>  125
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  125
aggaagaugu acggagacat t                                                 21


<210>  126
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  126
ugucuccgua caucuuccuu u                                                 21


<210>  127
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modifed as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  127
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  128
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  128
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  129
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl and any purine is 2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<400>  129
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  130
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl and any purine is 2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  130
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  131
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  131
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  132
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  132
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  133
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl and any purine is 2'-deoxy

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  133
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  134
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl and any purine is 2'-deoxy

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  134
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  135
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this  
       sequence

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  135
gacauuaacu cauuagacun n                                                 21


<210>  136
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  136
agucuaauga guuaaugucn n                                                 21


<210>  137
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<400>  137
gacauuaacu cauuagacun n                                                 21


<210>  138
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotidfe

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  138
agucuaauga guuaaugucn n                                                 21


<210>  139
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  139
gacauuaacu cauuagacun n                                                 21


<210>  140
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  140
agucuaauga guuaaugucn n                                                 21


<210>  141
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  141
gacauuaacu cauuagacun n                                                 21


<210>  142
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, iverted nucleotide or other terminal cap

<400>  142
agucuaauga guuaaugucn n                                                 21


<210>  143
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  143
agucuaauga guuaauguc                                                    19


<210>  144
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  144
uauacauucu ggugcugug                                                    19


<210>  145
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145
auagcaggca uauuacucg                                                    19


<210>  146
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146
acucguauaa gaugcuauc                                                    19


<210>  147
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  147
aacagauuua aauaacuug                                                    19


<210>  148
<211>  2358
<212>  DNA
<213>  Homo sapiens

<400>  148
aaacucacac aacaacucuu ccccgcugag aggagacagc cagugcgacu ccacccucca       60

gcucgacggc agccgccccg gccgacagcc ccgagacgac agcccggcgc gucccggucc      120

ccaccuccga ccaccgccag cgcuccaggc cccgccgcuc cccgcucgcc gccaccgcgc      180

ccuccgcucc gcccgcagug ccaaccauga ccgccgccag uaugggcccc guccgcgucg      240

ccuucguggu ccuccucgcc cucugcagcc ggccggccgu cggccagaac ugcagcgggc      300

cgugccggug cccggacgag ccggcgccgc gcugcccggc gggcgugagc cucgugcugg      360

acggcugcgg cugcugccgc gucugcgcca agcagcuggg cgagcugugc accgagcgcg      420

accccugcga cccgcacaag ggccucuucu gugacuucgg cuccccggcc aaccgcaaga      480

ucggcgugug caccgccaaa gauggugcuc ccugcaucuu cggugguacg guguaccgca      540

gcggagaguc cuuccagagc agcugcaagu accagugcac gugccuggac ggggcggugg      600

gcugcaugcc ccugugcagc auggacguuc gucugcccag cccugacugc cccuucccga      660

ggagggucaa gcugcccggg aaaugcugcg aggagugggu gugugacgag cccaaggacc      720

aaaccguggu ugggccugcc cucgcggcuu accgacugga agacacguuu ggcccagacc      780

caacuaugau uagagccaac ugccuggucc agaccacaga guggagcgcc uguuccaaga      840

ccugugggau gggcaucucc acccggguua ccaaugacaa cgccuccugc aggcuagaga      900

agcagagccg ccugugcaug gucaggccuu gcgaagcuga ccuggaagag aacauuaaga      960

agggcaaaaa gugcauccgu acucccaaaa ucuccaagcc uaucaaguuu gagcuuucug     1020

gcugcaccag caugaagaca uaccgagcua aauucugugg aguauguacc gacggccgau     1080

gcugcacccc ccacagaacc accacccugc cgguggaguu caagugcccu gacggcgagg     1140

ucaugaagaa gaacaugaug uucaucaaga ccugugccug ccauuacaac ugucccggag     1200

acaaugacau cuuugaaucg cuguacuaca ggaagaugua cggagacaug gcaugaagcc     1260

agagagugag agacauuaac ucauuagacu ggaacuugaa cugauucaca ucucauuuuu     1320

ccguaaaaau gauuucagua gcacaaguua uuuaaaucug uuuuucuaac ugggggaaaa     1380

gauucccacc caauucaaaa cauugugcca ugucaaacaa auagucuauc aaccccagac     1440

acugguuuga agaauguuaa gacuugacag uggaacuaca uuaguacaca gcaccagaau     1500

guauauuaag guguggcuuu aggagcagug ggaggguacc agcagaaagg uuaguaucau     1560

cagauagcau cuuauacgag uaauaugccu gcuauuugaa guguaauuga gaaggaaaau     1620

uuuagcgugc ucacugaccu gccuguagcc ccagugacag cuaggaugug cauucuccag     1680

ccaucaagag acugagucaa guuguuccuu aagucagaac agcagacuca gcucugacau     1740

ucugauucga augacacugu ucaggaaucg gaauccuguc gauuagacug gacagcuugu     1800

ggcaagugaa uuugccugua acaagccaga uuuuuuaaaa uuuauauugu aaauauugug     1860

ugugugugug uguguguaua uauauauaua uguacaguua ucuaaguuaa uuuaaaguug     1920

uuugugccuu uuuauuuuug uuuuuaaugc uuugauauuu caauguuagc cucaauuucu     1980

gaacaccaua gguagaaugu aaagcuuguc ugaucguuca aagcaugaaa uggauacuua     2040

uauggaaauu cugcucagau agaaugacag uccgucaaaa cagauuguuu gcaaagggga     2100

ggcaucagug uccuuggcag gcugauuucu agguaggaaa ugugguagcc ucacuuuuaa     2160

ugaacaaaug gccuuuauua aaaacugagu gacucuauau agcugaucag uuuuuucacc     2220

uggaagcauu uguuucuacu uugauaugac uguuuuucgg acaguuuauu uguugagagu     2280

gugaccaaaa guuacauguu ugcaccuuuc uaguugaaaa uaaaguguau auuuuuucua     2340

uaaaaaaaaa aaaaaaaa                                                   2358


