                         SEQUENCE LISTING

<110>  VALLERA, DANIEL A.
 
<120>  METHODS AND COMPOSITIONS FOR BI-SPECIFIC TARGETING OF CD19/CD22

<130>  VALL:002WO

<140>  UNKNOWN
<141>  2010-03-11

<150>  61/160,530
<151>  2009-03-16

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  904
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  1

Met Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu 
1               5                   10                  15      


Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile 
            20                  25                  30          


Gln Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp 
        35                  40                  45              


Asp Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala 
    50                  55                  60                  


Gly Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Val Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys 
                85                  90                  95      


Val Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr 
            100                 105                 110         


Glu Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe 
        115                 120                 125             


Gly Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly 
    130                 135                 140                 


Ser Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu 
145                 150                 155                 160 


Ser Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln 
                165                 170                 175     


Asp Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val 
            180                 185                 190         


Arg Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp 
        195                 200                 205             


Val Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His 
    210                 215                 220                 


Gly Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser 
225                 230                 235                 240 


Glu Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu 
                245                 250                 255     


Glu His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro 
            260                 265                 270         


Val Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln 
        275                 280                 285             


Val Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala 
    290                 295                 300                 


Leu Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly 
305                 310                 315                 320 


Ala Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu 
                325                 330                 335     


Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val 
            340                 345                 350         


Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu 
        355                 360                 365             


Phe Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly 
    370                 375                 380                 


His Lys Thr Gln Pro Phe Glu Ala Ser Gly Gly Pro Glu Asp Ile Gln 
385                 390                 395                 400 


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                405                 410                 415     


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp 
            420                 425                 430         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
        435                 440                 445             


Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    450                 455                 460                 


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Phe 
465                 470                 475                 480 


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly 
                485                 490                 495     


Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys 
            500                 505                 510         


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Gln Leu Val Glu 
        515                 520                 525             


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    530                 535                 540                 


Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr Asp Met Ser Trp Val Arg 
545                 550                 555                 560 


Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly 
                565                 570                 575     


Gly Gly Thr Thr Tyr Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile 
            580                 585                 590         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        595                 600                 605             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg His Ser Gly Tyr 
    610                 615                 620                 


Gly Thr His Trp Gly Val Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
625                 630                 635                 640 


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Asp Ile Leu Leu Thr Gln 
                645                 650                 655     


Thr Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
            660                 665                 670         


Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Leu Asn 
        675                 680                 685             


Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp 
    690                 695                 700                 


Ala Ser Asn Leu Val Ser Gly Ile Pro Pro Arg Phe Ser Gly Ser Gly 
705                 710                 715                 720 


Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Lys Val Asp 
                725                 730                 735     


Ala Ala Thr Tyr His Cys Gln Gln Ser Thr Glu Asp Pro Trp Thr Phe 
            740                 745                 750         


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Ser Thr Ser Gly Ser 
        755                 760                 765             


Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu 
    770                 775                 780                 


Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val Lys Ile 
785                 790                 795                 800 


Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met Asn Trp 
                805                 810                 815     


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln Ile Trp 
            820                 825                 830         


Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly Lys Ala 
        835                 840                 845             


Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
    850                 855                 860                 


Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg Glu 
865                 870                 875                 880 


Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
                885                 890                 895     


Gly Thr Ser Val Thr Val Ser Ser 
            900                 


<210>  2
<211>  2715
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  2
atgggcgctg atgatgttgt tgattcttct aaatcttttg tgatggaaaa cttttcttcg       60

taccacggga ctaaacctgg ttatgtagat tccattcaaa aaggtataca aaagccaaaa      120

tctggtacac aaggaaatta tgacgatgat tggaaagggt tttatagtac cgacaataaa      180

tacgacgctg cgggatactc tgtagataat gaaaacccgc tctctggaaa agctggaggc      240

gtggtcaaag tgacgtatcc aggactgacg aaggttctcg cactaaaagt ggataatgcc      300

gaaactatta agaaagagtt aggtttaagt ctcactgaac cgttgatgga gcaagtcgga      360

acggaagagt ttatcaaaag gttcggtgat ggtgcttcgc gtgtagtgct cagccttccc      420

ttcgctgagg ggagttctag cgttgaatat attaataact gggaacaggc gaaagcgtta      480

agcgtagaac ttgagattaa ttttgaaacc cgtggaaaac gtggccaaga tgcgatgtat      540

gagtatatgg ctcaagcctg tgcaggaaat cgtgtcaggc gatcagtagg tagctcattg      600

tcatgcataa atcttgattg ggatgtcata agggataaaa ctaagacaaa gatagagtct      660

ttgaaagagc atggccctat caaaaataaa atgagcgaaa gtcccaataa aacagtatct      720

gaggaaaaag ctaaacaata cctagaagaa tttcatcaaa cggcattaga gcatcctgaa      780

ttgtcagaac ttaaaaccgt tactgggacc aatcctgtat tcgctggggc taactatgcg      840

gcgtgggcag taaacgttgc gcaagttatc gatagcgaaa cagctgataa tttggaaaag      900

acaactgctg ctctttcgat acttcctggt atcggtagcg taatgggcat tgcagacggt      960

gccgttcacc acaatacaga agagatagtg gcacaatcaa tagctttatc gtctttaatg     1020

gttgctcaag ctattccatt ggtaggagag ctagttgata ttggtttcgc tgcatataat     1080

tttgtagaga gtattatcaa tttatttcaa gtagttcata attcgtataa tcgtcccgcg     1140

tattctccgg ggcataaaac gcaaccattt gaagcttccg gaggtcccga ggatattcaa     1200

atgactcaaa ctacttcttc tttgtctgct tctttgggtg atagagttac tatttcttgt     1260

agagcttctc aagatatttc taactacttg aactggtacc aacaaaagcc agatggtact     1320

gttaagttgt tgatttacta cacttccatt ttgcattctg gtgttccatc tagattctct     1380

ggttctggtt ctggtactga ttactctttg actatttcta acttggaaca agaagatttc     1440

gctacttact tctgtcaaca aggtaatact ttgccatgga ctttcggtgg tggtactaag     1500

ttggaaatta agggtagcac ctctggctcc ggaaaaccgg gaagcggtga agggtccacc     1560

aagggtgaag ttcaattggt tgaatctggt ggtggtttgg ttaagccagg tggttctttg     1620

aagttgtctt gtgctgcttc tggtttcgct ttctctattt acgatatgtc ttgggttaga     1680

caaactccag aaaagagatt ggaatgggtt gcttacattt cttctggtgg tggtactact     1740

tactacccag atactgttaa gggtagattc actatttcta gagataacgc taagaacact     1800

ttgtacctgc aaatgtcttc tctgaagtct gaagataccg ctatgtacta ctgtgctaga     1860

cattccggtt acggtaccca ctggggtgtt ttgttcgctt actggggtca aggtactttg     1920

gttactgttt ctgctggtgg cggtggatcc gatatcttgc tcacccaaac tccagcttct     1980

ttggctgtgt ctctagggca gagggccacc atctcctgca aggccagcca aagtgttgat     2040

tatgatggtg atagttattt gaactggtac caacagattc caggacagcc acccaaactc     2100

ctcatctatg atgcatccaa tctagtttct gggattccac ccaggtttag tggcagtggg     2160

tctgggacag acttcaccct caacatccat cctgtggaga aggtggatgc tgcaacctat     2220

cactgtcagc aaagtactga agatccgtgg acgttcggtg gaggcaccaa gctggaaatc     2280

aaacggggta gcacctctgg ctccggaaaa ccgggaagcg gtgaagggtc caccaagggt     2340

caggtgcagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt     2400

tcctgcaagg cttctggcta tgcattcagt agctactgga tgaactgggt gaagcagagg     2460

cctggacagg gtcttgagtg gattggacag atttggcctg gagatggtga tactaactac     2520

aatggaaagt tcaagggtaa agccactctg actgcagacg aatcctccag cacagcctac     2580

atgcaactca gcagcctagc atctgaggac tctgcggtct atttctgtgc aagacgggag     2640

actacgacgg taggccgtta ttactatgct atggactact ggggtcaagg aacctcagtc     2700

accgtctcct catag                                                      2715


<210>  3
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  3

Met Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu 
1               5                   10                  15      


Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile 
            20                  25                  30          


Gln Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp 
        35                  40                  45              


Asp Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala 
    50                  55                  60                  


Gly Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Val Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys 
                85                  90                  95      


Val Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr 
            100                 105                 110         


Glu Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe 
        115                 120                 125             


Gly Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly 
    130                 135                 140                 


Ser Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu 
145                 150                 155                 160 


Ser Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln 
                165                 170                 175     


Asp Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val 
            180                 185                 190         


Arg Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp 
        195                 200                 205             


Val Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His 
    210                 215                 220                 


Gly Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser 
225                 230                 235                 240 


Glu Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu 
                245                 250                 255     


Glu His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro 
            260                 265                 270         


Val Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln 
        275                 280                 285             


Val Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala 
    290                 295                 300                 


Leu Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly 
305                 310                 315                 320 


Ala Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu 
                325                 330                 335     


Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val 
            340                 345                 350         


Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu 
        355                 360                 365             


Phe Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly 
    370                 375                 380                 


His Lys Thr Gln Pro Phe 
385                 390 


<210>  4
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  4
atgggcgctg atgatgttgt tgattcttct aaatcttttg tgatggaaaa cttttcttcg       60

taccacggga ctaaacctgg ttatgtagat tccattcaaa aaggtataca aaagccaaaa      120

tctggtacac aaggaaatta tgacgatgat tggaaagggt tttatagtac cgacaataaa      180

tacgacgctg cgggatactc tgtagataat gaaaacccgc tctctggaaa agctggaggc      240

gtggtcaaag tgacgtatcc aggactgacg aaggttctcg cactaaaagt ggataatgcc      300

gaaactatta agaaagagtt aggtttaagt ctcactgaac cgttgatgga gcaagtcgga      360

acggaagagt ttatcaaaag gttcggtgat ggtgcttcgc gtgtagtgct cagccttccc      420

ttcgctgagg ggagttctag cgttgaatat attaataact gggaacaggc gaaagcgtta      480

agcgtagaac ttgagattaa ttttgaaacc cgtggaaaac gtggccaaga tgcgatgtat      540

gagtatatgg ctcaagcctg tgcaggaaat cgtgtcaggc gatcagtagg tagctcattg      600

tcatgcataa atcttgattg ggatgtcata agggataaaa ctaagacaaa gatagagtct      660

ttgaaagagc atggccctat caaaaataaa atgagcgaaa gtcccaataa aacagtatct      720

gaggaaaaag ctaaacaata cctagaagaa tttcatcaaa cggcattaga gcatcctgaa      780

ttgtcagaac ttaaaaccgt tactgggacc aatcctgtat tcgctggggc taactatgcg      840

gcgtgggcag taaacgttgc gcaagttatc gatagcgaaa cagctgataa tttggaaaag      900

acaactgctg ctctttcgat acttcctggt atcggtagcg taatgggcat tgcagacggt      960

gccgttcacc acaatacaga agagatagtg gcacaatcaa tagctttatc gtctttaatg     1020

gttgctcaag ctattccatt ggtaggagag ctagttgata ttggtttcgc tgcatataat     1080

tttgtagaga gtattatcaa tttatttcaa gtagttcata attcgtataa tcgtcccgcg     1140

tattctccgg ggcataaaac gcaaccattt                                      1170


<210>  5
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  5

Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His 
1               5                   10                  15      


Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu 
            20                  25                  30          


Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr 
        35                  40                  45              


Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn 
    50                  55                  60                  


Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg 
65                  70                  75                  80  


Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu 
                85                  90                  95      


Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala 
            100                 105                 110         


Ala Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu 
        115                 120                 125             


Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr 
    130                 135                 140                 


Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser 
145                 150                 155                 160 


Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His 
                165                 170                 175     


Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
            180                 185                 190         


Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg 
        195                 200                 205             


Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp 
    210                 215                 220                 


Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg 
225                 230                 235                 240 


Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser 
                245                 250                 255     


Ser Leu Pro Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu 
            260                 265                 270         


Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg 
        275                 280                 285             


Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr 
    290                 295                 300                 


Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala 
305                 310                 315                 320 


Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser 
                325                 330                 335     


Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser 
            340                 345                 350         


Gln Pro Gly Lys Pro Pro Lys Asp Glu Leu 
        355                 360         


<210>  6
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  6
cccgagggcg gcagcctggc cgcgctgacc gcgcaccagg cttgccacct gccgctggag       60

actttcaccc gtcatcgcca gccgcgcggc tgggaacaac tggagcagtg cggctatccg      120

gtgcagcggc tggtcgccct ctacctggcg gcgcggctgt cgtggaacca ggtcgaccag      180

gtgatccgca acgccctggc cagccccggc agcggcggcg acctgggcga agcgatccgc      240

gagcagccgg agcaggcccg tctggccctg accctggccg ccgccgagag cgagcgcttc      300

gtccggcagg gcaccggcaa cgacgaggcc ggcgcggcca acgccgacgt ggtgagcctg      360

acctgcccgg tcgccgccgg tgaatgcgcg ggcccggcgg acagcggcga cgccctgctg      420

gagcgcaact atcccactgg cgcggagttc ctcggcgacg gcggcgacgt cagcttcagc      480

acccgcggca cgcagaactg gacggtggag cggctgctcc aggcgcaccg ccaactggag      540

gagcgcggct atgtgttcgt cggctaccac ggcaccttcc tcgaagcggc gcaaagcatc      600

gtcttcggcg gggtgcgcgc gcgcagccag gacctcgacg cgatctggcg cggtttctat      660

atcgccggcg atccggcgct ggcctacggc tacgcccagg accaggaacc cgacgcacgc      720

ggccggatcc gcaacggtgc cctgctgcgg gtctatgtgc cgcgctcgag cctgccgggc      780

ttctaccgca ccagcctgac cctggccgcg ccggaggcgg cgggcgaggt cgaacggctg      840

atcggccatc cgctgccgct gcgcctggac gccatcaccg gccccgagga ggaaggcggg      900

cgcctggaga ccattctcgg ctggccgctg gccgagcgca ccgtggtgat tccctcggcg      960

atccccaccg acccgcgcaa cgtcggcggc gacctcgacc cgtccagcat ccccgacaag     1020

gaacaggcga tcagcgccct gccggactac gccagccagc ccggcaaacc gccgaaggac     1080

gagctatga                                                             1089


<210>  7
<211>  877
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu 
    130                 135                 140                 


Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr Asp Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Tyr 
                165                 170                 175     


Ile Ser Ser Gly Gly Gly Thr Thr Tyr Tyr Pro Asp Thr Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


His Ser Gly Tyr Gly Thr His Trp Gly Val Leu Phe Ala Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Asp Ile 
                245                 250                 255     


Leu Leu Thr Gln Thr Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
            260                 265                 270         


Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp 
        275                 280                 285             


Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro Lys Leu 
    290                 295                 300                 


Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val 
                325                 330                 335     


Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr Glu Asp 
            340                 345                 350         


Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Ser 
        355                 360                 365             


Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly 
    370                 375                 380                 


Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
385                 390                 395                 400 


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
                405                 410                 415     


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
            420                 425                 430         


Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
        435                 440                 445             


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
    450                 455                 460                 


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
465                 470                 475                 480 


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
                485                 490                 495     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu Ala Ser Gly 
            500                 505                 510         


Gly Pro Glu Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln 
        515                 520                 525             


Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg 
    530                 535                 540                 


Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val 
545                 550                 555                 560 


Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val 
                565                 570                 575     


Ile Ala Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu 
            580                 585                 590         


Ala Ile Arg Glu Ser Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala 
        595                 600                 605             


Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu 
    610                 615                 620                 


Ala Gly Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala 
625                 630                 635                 640 


Ala Gly Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu 
                645                 650                 655     


Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val 
            660                 665                 670         


Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu 
        675                 680                 685             


Gln Ala His Arg Gln Leu Glu Glu Gly Gly Tyr Val Phe Val Gly Tyr 
    690                 695                 700                 


His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val 
705                 710                 715                 720 


Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Ala Gly Phe Tyr Ile 
                725                 730                 735     


Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro 
            740                 745                 750         


Asp Ala Ala Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val 
        755                 760                 765             


Pro Arg Ser Ser Leu Pro Gly Phe Tyr Ala Thr Ser Leu Thr Leu Ala 
    770                 775                 780                 


Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu 
785                 790                 795                 800 


Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Ser Gly Gly Arg 
                805                 810                 815     


Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile 
            820                 825                 830         


Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp 
        835                 840                 845             


Pro Ser Ser Ile Pro Asp Ser Glu Gln Ala Ile Ser Ala Leu Pro Asp 
    850                 855                 860                 


Tyr Ala Ser Gln Pro Gly Lys Pro Pro Lys Asp Glu Leu 
865                 870                 875         


<210>  8
<211>  2634
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  8
atggatattc aaatgactca aactacttct tctttgtctg cttctttggg tgatagagtt       60

actatttctt gtagagcttc tcaagatatt tctaactact tgaactggta ccaacaaaag      120

ccagatggta ctgttaagtt gttgatttac tacacttcca ttttgcattc tggtgttcca      180

tctagattct ctggttctgg ttctggtact gattactctt tgactatttc taacttggaa      240

caagaagatt tcgctactta cttctgtcaa caaggtaata ctttgccttg gactttcggt      300

ggtggtacta agttggaaat taagggtagc acctctggct ccggaaaacc gggaagcggt      360

gaagggtcca ccaagggtga agttcaattg gttgaatctg gtggtggttt ggttaagcca      420

ggtggttctt tgaagttgtc ttgtgctgct tctggtttcg ctttctctat ttacgatatg      480

tcttgggtta gacaaactcc agaaaagaga ttggaatggg ttgcttacat ttcttctggt      540

ggtggtacta cttactaccc agatactgtt aagggtagat tcactatttc tagagataac      600

gctaagaaca ctttgtacct gcaaatgtct tctctgaagt ctgaagatac cgctatgtac      660

tactgtgcta gacattccgg ttacggtacc cactggggtg ttttgttcgc ttactggggt      720

caaggtactt tggttactgt ttctgctggt ggcggtggat ccgatatctt gctcacccaa      780

actccagctt ctttggctgt gtctctaggg cagagggcca ccatctcctg caaggccagc      840

caaagtgttg attatgatgg tgatagttat ttgaactggt accaacagat tccaggacag      900

ccacccaaac tcctcatcta tgatgcatcc aatctagttt ctgggattcc acccaggttt      960

agtggcagtg ggtctgggac agacttcacc ctcaacatcc atcctgtgga gaaggtggat     1020

gctgcaacct atcactgtca gcaaagtact gaagatccgt ggacgttcgg tggaggcacc     1080

aagctggaaa tcaaacgggg tagcacctct ggctccggaa aaccgggaag cggtgaaggg     1140

tccaccaagg gtcaggtgca gctgcagcag tctggggctg agctggtgag gcctgggtcc     1200

tcagtgaaga tttcctgcaa ggcttctggc tatgcattca gtagctactg gatgaactgg     1260

gtgaagcaga ggcctggaca gggtcttgag tggattggac agatttggcc tggagatggt     1320

gatactaact acaatggaaa gttcaagggt aaagccactc tgactgcaga cgaatcctcc     1380

agcacagcct acatgcaact cagcagccta gcatctgagg actctgcggt ctatttctgt     1440

gcaagacggg agactacgac ggtaggccgt tattactatg ctatggacta ctggggtcaa     1500

ggaacctcag tcaccgtctc ctcagaagct tccggaggtc ccgagcccga gggcggcagc     1560

ctggccgcgc tgaccgcgca ccaggcttgc cacctgccgc tggagacttt cacccgtcat     1620

cgccagccgc gcggctggga acaactggag cagtgcggct atccggtgca gcggctggtc     1680

gccctctacc tggcggcgcg gctgtcgtgg aaccaggtcg accaggtgat cgccaacgcc     1740

ctggccagcc ccggcagcgg cggcgacctg ggcgaagcga tccgcgagtc gccggagcag     1800

gcccgtctgg ccctgaccct ggccgccgcc gagagcgagc gcttcgtccg gcagggcacc     1860

ggcaacgacg aggccggcgc ggccaacgcc gacgtggtga gcctgacctg cccggtcgcc     1920

gccggtgaat gcgcgggccc ggcggacagc ggcgacgccc tgctggagcg caactatccc     1980

actggcgcgg agttcctcgg cgacggcggc gacgtcagct tcagcacccg cggcacgcag     2040

aactggacgg tggagcggct gctccaggcg caccgccaac tggaggaggg aggctatgtg     2100

ttcgtcggct accacggcac cttcctcgaa gcggcgcaaa gcatcgtctt cggcggggtg     2160

cgcgcgcgca gccaggacct cgacgcgatc tgggccggtt tctatatcgc cggcgatccg     2220

gcgctggcct acggctacgc ccaggaccag gaacccgacg cagccggccg gatccgcaac     2280

ggtgccctgc tgcgggtcta tgtgccgcgc tcgagcctgc cgggcttcta cgccaccagc     2340

ctgaccctgg ccgcgccgga ggcggcgggc gaggtcgaac ggctgatcgg ccatccgctg     2400

ccgctgcgcc tggacgccat caccggcccc gaggagtcag gcgggcgcct ggagaccatt     2460

ctcggctggc cgctggccga gcgcaccgtg gtgattccct cggcgatccc caccgacccg     2520

cgcaacgtcg gcggcgacct cgacccgtcc agcatccccg actcggaaca ggcgatcagc     2580

gccctgccgg actacgccag ccagcccggc aaaccgccga aggacgagct atga           2634


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
1               5                   10                  


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Lys Ala Ala Lys Lys Ala Ala Lys Ala Ala Lys Lys Ala Ala 
1               5                   10                  


<210>  12
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Lys Leu Gly Lys Lys Leu Gly Lys Leu Gly Lys Lys Leu Gly Lys Leu 
1               5                   10                  15      


Gly Lys Lys Leu Gly 
            20      


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
1               5                   10                  15      


Asn His Ala Tyr 
            20  


<210>  14
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


