                         SEQUENCE LISTING

<110>  Nordic Bioscience A/S
 
<120>  Treatment of Diabetes and Metabolic Syndrome

<130>  PJS/P16582WO

<150>  GB 0904271.4
<151>  2009-03-12

<150>  GB 0910904.2
<151>  2009-06-24

<150>  GB 0912906.5
<151>  2009-07-24

<160>  56    

<170>  PatentIn version 3.3

<210>  1
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  1

Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp Phe 
1               5                   10                  15      


Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
            20                  25                  30          


<210>  2
<211>  32
<212>  PRT
<213>  Salmon

<400>  2

Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Lys Leu Ser Gln Glu Leu 
1               5                   10                  15      


His Lys Leu Gln Thr Tyr Pro Arg Thr Asn Thr Gly Ser Gly Thr Pro 
            20                  25                  30          


<210>  3
<211>  32
<212>  PRT
<213>  Mus musculus

<400>  3

Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp Leu 
1               5                   10                  15      


Asn Lys Phe His Thr Phe Pro Gln Thr Ser Ile Gly Val Glu Ala Pro 
            20                  25                  30          


<210>  4
<211>  32
<212>  PRT
<213>  Gallus gallus domesticus

<400>  4

Cys Ala Ser Leu Ser Thr Cys Val Leu Gly Lys Leu Ser Gln Glu Leu 
1               5                   10                  15      


His Lys Leu Gln Thr Tyr Pro Arg Thr Asp Val Gly Ala Gly Thr Pro 
            20                  25                  30          


<210>  5
<211>  32
<212>  PRT
<213>  Anguilla anguilla

<400>  5

Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Lys Leu Ser Gln Glu Leu 
1               5                   10                  15      


His Lys Leu Gln Thr Tyr Pro Arg Thr Asp Val Gly Ala Gly Thr Pro 
            20                  25                  30          


<210>  6
<211>  32
<212>  PRT
<213>  Rattus

<400>  6

Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp Leu 
1               5                   10                  15      


Asn Lys Phe His Thr Phe Pro Gln Thr Ser Ile Gly Val Gly Ala Pro 
            20                  25                  30          


<210>  7
<211>  32
<212>  PRT
<213>  Equus ferus caballus

<400>  7

Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Thr Tyr Thr Gln Asp Leu 
1               5                   10                  15      


Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
            20                  25                  30          


<210>  8
<211>  32
<212>  PRT
<213>  Canis lupus familiaris

<400>  8

Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Thr Tyr Ser Lys Asp Leu 
1               5                   10                  15      


Asn Asn Phe His Thr Phe Ser Gly Ile Gly Phe Gly Ala Glu Thr Pro 
            20                  25                  30          


<210>  9
<211>  32
<212>  PRT
<213>  Canis lupus familiaris

<400>  9

Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Thr Tyr Thr Gln Asp Leu 
1               5                   10                  15      


Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
            20                  25                  30          


<210>  10
<211>  32
<212>  PRT
<213>  Sus domestica

<400>  10

Cys Ser Asn Leu Ser Thr Cys Val Leu Ser Ala Tyr Trp Arg Asn Leu 
1               5                   10                  15      


Asn Asn Phe His Arg Phe Ser Gly Met Gly Phe Gly Pro Glu Thr Pro 
            20                  25                  30          


<210>  11
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  General formula


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  A, G, OR S

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N OR S

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  M OR V

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  G OR S

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  T, K OR A

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  L OR Y

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  T, S OR W

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Q, K, OR R

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  D, E, OR N

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  F OR L

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  N OR H

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  K OR N

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  F OR L

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  T OR R

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  F OR Y

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  P OR S

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Q, G, OR R

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  T, I, OR M

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  A, N, D, S, OR G

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  I, T, V, OR F

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  V, S, A, OR P

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  G OR E

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  A OR T

<400>  11

Cys Xaa Xaa Leu Ser Thr Cys Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Pro 
            20                  25                  30          


<210>  12
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  General formula


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  T OR K

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  T OR S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  D OR E

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Q OR R

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  V, S, OR A

<400>  12

Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Xaa Leu Xaa Gln Xaa Leu 
1               5                   10                  15      


His Lys Leu Gln Thr Tyr Pro Xaa Thr Asn Thr Gly Xaa Gly Thr Pro 
            20                  25                  30          


<210>  13
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  14
<211>  37
<212>  PRT
<213>  Mus musculus

<400>  14

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  15
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  16
<211>  37
<212>  PRT
<213>  Sus domestica

<400>  16

Ser Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Met Val Lys Ser Asn Phe Val Pro Thr Asp Val 
            20                  25                  30          


Gly Ser Glu Ala Phe 
        35          


<210>  17
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Gln Ala Gln Leu Leu Arg Val Gly Cys Val Leu Gly Thr Cys Gln 
1               5                   10                  15      


Val Gln Asn Leu Ser His Arg Leu Trp Gln Leu Met Gly Pro Ala Gly 
            20                  25                  30          


Arg Gln Asp Ser Ala Pro Val Asp Pro Ser Ser Pro His Ser Tyr 
        35                  40                  45          


<210>  18
<211>  52
<212>  PRT
<213>  Sus domestica

<400>  18

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys 
1               5                   10                  15      


Arg Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln 
            20                  25                  30          


Phe Thr Asp Lys Asp Lys Asp Gly Val Ala Pro Arg Ser Lys Ile Ser 
        35                  40                  45              


Pro Gln Gly Tyr 
    50          


<210>  19
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  19

Val Gly Cys Val Leu Gly Thr Cys Gln Val Gln Asn Leu Ser His Arg 
1               5                   10                  15      


Leu Trp Gln Leu Met Gly Pro Ala Gly Arg Gln Asp Ser Ala Pro Val 
            20                  25                  30          


Asp Pro Ser Ser Pro His Ser Tyr 
        35                  40  


<210>  20
<211>  37
<212>  PRT
<213>  Bos primigenius

<400>  20

Ala Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Met Val Lys Ser Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  21
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Met Val Lys Ser Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  22
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Cys Asn Thr Ala Thr Cys Met Thr His Arg Leu Ala Gly Trp Leu 
1               5                   10                  15      


Ser Arg Ser Gly Ser Met Val Arg Ser Asn Leu Leu Pro Thr Lys Met 
            20                  25                  30          


Gly Phe Lys Ile Phe Asn Gly Pro Arg Arg Asn Ser Trp Phe 
        35                  40                  45      


<210>  23
<211>  46
<212>  PRT
<213>  Capra aegagrus hircus

<400>  23

Ala Cys Asn Thr Ala Thr Cys Met Thr His Arg Leu Ala Gly Trp Leu 
1               5                   10                  15      


Ser Arg Ser Gly Ser Met Val Arg Ser Asn Leu Leu Pro Thr Lys Met 
            20                  25                  30          


Gly Phe Lys Ile Phe Ser Gly Pro Arg Lys Asn Phe Trp Phe 
        35                  40                  45      


<210>  24
<211>  38
<212>  PRT
<213>  Canis lupus familiaris

<400>  24

Ser Cys Asn Ser Ala Thr Cys Val Ala His Trp Leu Gly Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ala Gly Ser Val Ala Asn Thr Asn Leu Leu Pro Thr Ser Met 
            20                  25                  30          


Gly Phe Lys Val Tyr Asn 
        35              


<210>  25
<211>  40
<212>  PRT
<213>  Ovis aries

<400>  25

Ala Cys Asn Thr Ala Thr Cys Met Thr His Arg Leu Ala Gly Trp Leu 
1               5                   10                  15      


Ser Arg Ser Gly Ser Met Val Arg Ser Asn Leu Leu Pro Thr Lys Met 
            20                  25                  30          


Gly Phe Lys Ile Phe Ser Gly Pro 
        35                  40  


<210>  26
<211>  40
<212>  PRT
<213>  Bos primigenius

<400>  26

Ala Cys Asn Thr Ala Thr Cys Met Thr His Arg Leu Ala Gly Trp Leu 
1               5                   10                  15      


Ser Arg Ser Gly Ser Met Val Arg Ser Asn Leu Leu Pro Thr Lys Met 
            20                  25                  30          


Gly Phe Lys Ile Phe Asn Gly Pro 
        35                  40  


<210>  27
<211>  38
<212>  PRT
<213>  Sus domestica

<400>  27

Ser Cys Asn Thr Ala Thr Cys Met Thr His Arg Leu Val Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Ser Met Val Arg Ser Asn Leu Leu Pro Thr Lys Met 
            20                  25                  30          


Gly Phe Lys Val Phe Gly 
        35              


<210>  28
<211>  37
<212>  PRT
<213>  Equus ferus caballus

<400>  28

Ser Cys Asn Thr Ala Ser Cys Leu Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Ser Ala Gly Ser Met Ala Asn Ser Asn Leu Leu Pro Thr Glu Met 
            20                  25                  30          


Gly Phe Lys Val Ser 
        35          


<210>  29
<211>  47
<212>  PRT
<213>  Canis lupus familiaris

<400>  29

Ser Ser Cys Lys Asp Gly Pro Cys Val Thr Asn Arg Leu Glu Gly Trp 
1               5                   10                  15      


Leu Ala Arg Ala Glu Arg Met Val Lys Asn Thr Phe Met Pro Thr Asp 
            20                  25                  30          


Val Asp Pro Glu Ala Phe Gly His Gln His Lys Glu Leu Ala Ala 
        35                  40                  45          


<210>  30
<211>  39
<212>  PRT
<213>  Capra aegagrus hircus

<400>  30

Ser Cys Asn Arg Ala Thr Cys Val Thr His Lys Met Ala Gly Ser Leu 
1               5                   10                  15      


Ser Arg Ser Gly Ser Glu Ile Lys Arg Asn Phe Met Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe Gly Gln 
        35                  


<210>  31
<211>  37
<212>  PRT
<213>  Sus domestica

<400>  31

Ser Cys Asn Thr Ala Ser Cys Val Thr His Lys Met Thr Gly Trp Leu 
1               5                   10                  15      


Ser Arg Ser Gly Ser Val Ala Lys Asn Asn Phe Met Pro Thr Asn Val 
            20                  25                  30          


Asp Ser Lys Ile Leu 
        35          


<210>  32
<211>  47
<212>  PRT
<213>  Canis lupus familiaris

<400>  32

Ser Ser Cys Lys Asp Gly Pro Cys Val Thr Asn Arg Leu Glu Gly Trp 
1               5                   10                  15      


Leu Ala Arg Ala Glu Arg Met Val Lys Asn Thr Phe Met Pro Thr Asp 
            20                  25                  30          


Val Asp Pro Glu Ala Phe Gly His Gln His Lys Glu Leu Ala Ala 
        35                  40                  45          


<210>  33
<211>  37
<212>  PRT
<213>  Sus domestica

<400>  33

Ser Cys Asn Thr Ala Ile Cys Val Thr His Lys Met Ala Gly Trp Leu 
1               5                   10                  15      


Ser Arg Ser Gly Ser Val Val Lys Asn Asn Phe Met Pro Ile Asn Met 
            20                  25                  30          


Gly Ser Lys Val Leu 
        35          


<210>  34
<211>  47
<212>  PRT
<213>  Canis lupus familiaris

<400>  34

Ser Ser Cys Lys Asp Gly Pro Cys Val Thr Asn Arg Leu Glu Gly Trp 
1               5                   10                  15      


Leu Ala Arg Ala Glu Arg Met Val Lys Asn Thr Phe Met Pro Thr Asp 
            20                  25                  30          


Val Asp Pro Glu Ala Phe Gly His Gln His Lys Glu Leu Ala Ala 
        35                  40                  45          


<210>  35
<211>  47
<212>  PRT
<213>  Canis lupus familiaris

<400>  35

Ser Ser Cys Lys Asp Gly Pro Cys Val Thr Asn Arg Leu Glu Gly Trp 
1               5                   10                  15      


Leu Ala Arg Ala Glu Arg Met Val Lys Asn Thr Phe Met Pro Thr His 
            20                  25                  30          


Val Asp Pro Glu Asp Phe Gly His Gln His Lys Glu Leu Ala Ala 
        35                  40                  45          


<210>  36
<211>  32
<212>  PRT
<213>  Salmon


<220>
<221>  CHAIN
<222>  (1)..(6)
<223>  (CH2)5 bridge

<400>  36

Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Lys Leu Ser Gln Glu Leu 
1               5                   10                  15      


His Lys Leu Gln Thr Tyr Pro Arg Thr Asn Thr Gly Ser Gly Thr Pro 
            20                  25                  30          


<210>  37
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  General formula


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  S, G, OR A

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  V OR M

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  T OR K

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  T OR L

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  T OR S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  D OR Q

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  F OR L

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  N OR H

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Y, F, OR L

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  H OR Q

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Y OR F

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Q OR R

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  A, S, N OR D

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  I, T, OR V

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  V, S OR A

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  A, T, OR V

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  amidized homoserine, homoserine-lactone reacted with a primary 
       alkyl amine containing 1 - 20 carbon atoms or an optional 
       polypeptide chain and containing an amidized homoserine at the 
       C-terminal.

<400>  37

Cys Xaa Asn Leu Ser Thr Cys Xaa Leu Gly Xaa Xaa Xaa Gly Xaa Xaa 
1               5                   10                  15      


Xaa Leu Xaa Xaa Thr Xaa Pro Xaa Thr Xaa Xaa Gly Xaa Gly Xaa Pro 
            20                  25                  30          


<210>  38
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  38

Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Lys Leu Ser Gln Glu Leu 
1               5                   10                  15      


His Lys Leu Gln Thr Tyr Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
            20                  25                  30          


<210>  39
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  39

Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp Phe 
1               5                   10                  15      


Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
            20                  25                  30          


<210>  40
<211>  37
<212>  PRT
<213>  rat

<400>  40

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  41
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  41

Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Lys Ala Phe 
        35      


<210>  42
<211>  38
<212>  PRT
<213>  artificial

<220>
<223>  sythetic construct

<400>  42

Tyr Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu 
1               5                   10                  15      


Leu Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr Asn 
            20                  25                  30          


Val Gly Ser Lys Ala Phe 
        35              


<210>  43
<211>  37
<212>  PRT
<213>  artificial

<220>
<223>  sythetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Cys(Et)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Cys(Et)

<400>  43

Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  44
<211>  37
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Cys(Acm)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Cys(Acm)

<400>  44

Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  45
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  45

Ala Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Met Val Lys Ser Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  46
<211>  40
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  46

Gln Leu Met Gly Pro Ala Gly Arg Gln Asp Ser Ala Pro Val Asp Pro 
1               5                   10                  15      


Ser Ser Pro His Ser Tyr Val Gly Cys Val Leu Gly Thr Cys Gln Val 
            20                  25                  30          


Gln Asn Leu Ser His Arg Leu Trp 
        35                  40  


<210>  47
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  47

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys 
1               5                   10                  15      


Arg Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln 
            20                  25                  30          


Phe Thr Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser 
        35                  40                  45              


Pro Gln Gly Tyr 
    50          


<210>  48
<211>  37
<212>  PRT
<213>  rat

<400>  48

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  49
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  49

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  50
<211>  37
<212>  PRT
<213>  cat

<400>  50

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Ile Arg Ser Ser Asn Asn Leu Gly Ala Ile Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  51
<211>  37
<212>  PRT
<213>  guinea pig

<400>  51

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Thr Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser His Asn Leu Gly Ala Ala Leu Leu Pro Thr Asp Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  52
<211>  37
<212>  PRT
<213>  new world rodent

<400>  52

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Thr Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser His Asn Leu Gly Ala Ala Leu Pro Pro Thr Lys Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  53
<211>  36
<212>  PRT
<213>  Syrinan Hamster

<400>  53

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Asn Asn Leu Gly Pro Val Leu Ser Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210>  54
<211>  37
<212>  PRT
<213>  dog

<400>  54

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Thr Ser Asn Asn Leu Gly Ala Ile Leu Ser Pro Thr Asn Val 
            20                  25                  30          


Gly Thr Asn Thr Tyr 
        35          


<210>  55
<211>  37
<212>  PRT
<213>  rat

<400>  55

Ser Gly Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asp Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Glu Ala Phe 
        35          


<210>  56
<211>  37
<212>  PRT
<213>  rat

<400>  56

Ser Gly Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Asn Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asp Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


