
                                SEQUENCE LISTING

<110> Cheek, Robert L.
      Dixon, Eric P.
      Fischer, Timothy J.
      Groelke, John W.
      Knapp, Steven L.
      Simkins, Stephen G.
      Whitehead, Clark M.

<120> GLYCODELIN MONOCLONAL ANTIBODIES AND
  METHODS FOR THEIR USE IN THE DETECTION OF OVARIAN CANCER
  

<130> 046143/386563

<150> 61/158,159          
<151> 2009-03-06  

<160> 9

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 180
<212> PRT
<213> Homo sapiens

<400> 1
Met Leu Cys Leu Leu Leu Thr Leu Gly Val Ala Leu Val Cys Gly Val
 1               5                  10                  15      
Pro Ala Met Asp Ile Pro Gln Thr Lys Gln Asp Leu Glu Leu Pro Lys
            20                  25                  30          
Leu Ala Gly Thr Trp His Ser Met Ala Met Ala Thr Asn Asn Ile Ser
        35                  40                  45              
Leu Met Ala Thr Leu Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu
    50                  55                  60                  
Leu Pro Thr Pro Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu
65                  70                  75                  80  
Asn Asn Ser Cys Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn
                85                  90                  95      
Pro Lys Lys Phe Lys Ile Asn Tyr Thr Val Ala Asn Glu Ala Thr Leu
            100                 105                 110         
Leu Asp Thr Asp Tyr Asp Asn Phe Leu Phe Leu Cys Leu Gln Asp Thr
        115                 120                 125             
Thr Thr Pro Ile Gln Ser Met Met Cys Gln Tyr Leu Ala Arg Val Leu
    130                 135                 140                 
Val Glu Asp Asp Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro
145                 150                 155                 160 
Leu Pro Arg His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu
                165                 170                 175     
Pro Cys Arg Phe
            180 


<210> 2
<211> 857
<212> DNA
<213> Homo sapiens

<400> 2
catccctctg gctccagagc tcagagccac ccacagccgc agccatgctg tgcctcctgc 60
tcaccctggg cgtggccctg gtctgtggtg tcccggccat ggacatcccc cagaccaagc 120
aggacctgga gctcccaaag ttggcaggga cctggcactc catggccatg gcgaccaaca 180
acatctccct catggcgaca ctgaaggccc ctctgagggt ccacatcacc tcactgttgc 240
ccacccccga ggacaacctg gagatcgttc tgcacagatg ggagaacaac agctgtgttg 300
agaagaaggt ccttggagag aagactgaga atccaaagaa gttcaagatc aactatacgg 360
tggcgaacga ggccacgctg ctcgatactg actacgacaa tttcctgttt ctctgcctac 420
aggacaccac cacccccatc cagagcatga tgtgccagta cctggccaga gtcctggtgg 480
aggacgatga gatcatgcag ggattcatca gggctttcag gcccctgccc aggcacctat 540
ggtacttgct ggacttgaaa cagatggaag agccgtgccg tttctaggtg agctcctgcc 600
tggtcctgcc tcctggctca cctccgcctc caggaagacc agactcccac ccttccacac 660
ctccagagca gtgggacttc ctcctgccct ttcaaagaat aaccacagct cagaagacga 720
tgacgtggtc atctgtgtcg ccatcccctt cctgctgcac acctgcacca cggccatggg 780
gaggctgctc cctgggggca gagtctctgg cagaggttat taataaaccc ttggagcatg 840
aaaaaaaaaa aaaaaaa                                                857

<210> 3
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Epitope sequence forglycodelin monoclonal antibody
      designated as 2G7.1
      

<400> 3
Ala Thr Leu Leu Asp Thr Asp Tyr Asp Asn Phe Leu Phe Leu Cys Leu
 1               5                  10                  15      
Gln Asp Thr Thr Thr Pro Ile Gln Ser Met Met Cys Gln Tyr Leu
            20                  25                  30      


<210> 4
<211> 190
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycodelin sequence fused to a small polypeptide
      linker and a carboxy-terminal hexahistidine tag
      (immunogenic polypeptide)
      
      

<400> 4
Met Leu Cys Leu Leu Leu Thr Leu Gly Val Ala Leu Val Cys Gly Val
 1               5                  10                  15      
Pro Ala Met Asp Ile Pro Gln Thr Lys Gln Asp Leu Glu Leu Pro Lys
            20                  25                  30          
Leu Ala Gly Thr Trp Arg Ser Met Ala Met Ala Thr Asn Asn Ile Ser
        35                  40                  45              
Leu Met Ala Thr Leu Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu
    50                  55                  60                  
Leu Pro Thr Pro Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu
65                  70                  75                  80  
Asn Asn Ser Cys Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn
                85                  90                  95      
Pro Lys Lys Phe Lys Ile Asn Tyr Thr Val Ala Asn Glu Ala Thr Leu
            100                 105                 110         
Leu Asp Thr Asp Tyr Asp Asn Phe Leu Phe Leu Cys Leu Gln Asp Thr
        115                 120                 125             
Thr Thr Pro Ile Gln Ser Met Met Cys Gln Tyr Leu Ala Arg Val Leu
    130                 135                 140                 
Val Glu Asp Asp Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro
145                 150                 155                 160 
Leu Pro Arg His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu
                165                 170                 175     
Pro Cys Arg Phe Leu Glu Gly Gly His His His His His His
            180                 185                 190 


<210> 5
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Minimal epitope sequence of glycodelin monoclonal
      antibody designated as 2G7.1

<400> 5
Pro Ile Gln Ser
 1              


<210> 6
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Part of full epitope sequence of glycodelin
      monoclonal antibody designated as 2G7.1

<400> 6
Arg Pro Leu Pro
 1              


<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Part of full epitope sequence of glycodelin
      monoclonal antibody designated as 2G7.1

<400> 7
Leu Met Ala Thr Leu Lys Ala Pro Leu
 1               5                  


<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Part of conformational epitope sequences of
      glycodelin monoclonal antibodies designated as
      8G8.3 and 3A10.25

<400> 8
Arg Trp Glu Asn Asn Ser Cys Val Glu
 1               5                  


<210> 9
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Part of conformational epitope sequences of
      glycodelin monoclonal antibodies designated as
      8G8.3 and 3A10.25

<400> 9
Lys Gln Met Glu Glu Pro Cys Arg Phe
 1               5                  

